Communicative aspects and coping strategies in patients with Parkinson's disease
Communicative aspects and coping strategies in patients with Parkinson's disease: RESUMO Objetivo: Investigar as estratégias de enfrentamento utilizadas por indivíduos com doença de Parkinson (DP), os sintomas vocais mais relatados, os problemas de comunicação mais presentes e a relação entre o tipo de enfrentamento, os sintomas vocais e os aspectos comunicativos. Métodos: Participaram 73 indivíduos, 33 do grupo experimental, com diagnóstico de DP e apresentando desvio vocal, e 40 do grupo controle (GC), saudáveis, sem desvio vocal. Eles foram submetidos aos seguintes procedimentos:... περισσότερα »
Methods of analysis speech rate: a pilot study
Methods of analysis speech rate: a pilot study: RESUMO Objetivo: Descrever o desempenho de adultos fluentes em diferentes medidas de velocidade de fala. Métodos: Participaram do estudo 24 adultos fluentes, de ambos os gêneros, falantes da variante mineira do Português Brasileiro, nascidos e residentes na região metropolitana de Belo Horizonte, Minas Gerais, com faixa etária entre 18 e 59 anos de idade. Os participantes foram agrupados por faixa etária em: G1 (18 a 29 anos), G2 (30 a 39 anos), G3 (40 a 49 anos) e G4 (50 a 59 anos). A coleta da amostra de fala seguiu a metodologia do ... περισσότερα »
Ocular and cervical vestibular evoked myogenic potential simultaneous in normal individuals
Ocular and cervical vestibular evoked myogenic potential simultaneous in normal individuals: RESUMO Objetivo: Caracterizar o registro e analisar os resultados do potencial evocado miogênico vestibular cervical e ocular combinado em indivíduos sem queixas auditivas e vestibulares. Métodos: Participaram da pesquisa 30 indivíduos sem queixa auditiva e com audição dentro dos padrões de normalidade. A coleta de dados foi realizada por meio do potencial evocado miogênico vestibular cervical e ocular registrados simultaneamente. Resultados: Houve diferença entre as orelhas direita e esquer...περισσότερα »
Auditory training program in subjects with tinnitus
Auditory training program in subjects with tinnitus: RESUMO O zumbido pode ser definido como a percepção consciente de um som, sem a presença de estimulação acústica externa. Considerando o prejuízo causado pelo zumbido e a falta de tratamentos definitivos, fica evidente a necessidade de alternativas para reabilitação de pessoas com zumbido. A hipótese é que o treinamento auditivo pode causar uma reorganização plástica desse sistema, promovendo uma melhora do sintoma. Objetivo: Verificar o efeito de um programa de treinamento auditivo em portadores de zumbido na percepção desse sint...περισσότερα »
Speech perception in users of hearing aid with auditory neuropathy spectrum disorder
Speech perception in users of hearing aid with auditory neuropathy spectrum disorder: RESUMO Objetivo: Analisar a percepção de fala em crianças portadoras de deficiência auditiva pré-lingual com desordem do espectro da neuropatia auditiva (DENA) usuárias de aparelho de amplificação sonora individual (AASI) bilateral. Métodos: Trata-se de um estudo descritivo e exploratório realizado no Centro de Pesquisas Audiológicas da Sessão de Implante Coclear do Hospital de Reabilitação de Anomalias Craniofaciais (HRAC/USP). Foram avaliadas 4 crianças com idade variando entre 8 anos e 3 meses e... περισσότερα »
Signs and symptoms of temporomandibular disorders in women and men
Signs and symptoms of temporomandibular disorders in women and men: RESUMO Introdução: Mulheres são mais susceptíveis às desordens temporomandibulares (DTM), contudo, estudos que tenham comparado os gêneros em amostras brasileiras são raros. Objetivo: Analisar a proporção de homens e mulheres, bem como a associação entre o gênero e as variáveis idade, duração do problema e sintomas de DTM em pacientes admitidos para tratamento em uma clínica universitária. Métodos: Foram coletados e analisados dados de entrevista e avaliação de mil protocolos de pacientes com diagnóstico de DTM, div... περισσότερα »
Multimedia material about velopharynx and primary palatoplasty for orientation of caregivers of children with cleft lip and palate
Multimedia material about velopharynx and primary palatoplasty for orientation of caregivers of children with cleft lip and palate: RESUMO Objetivo: O objetivo deste trabalho é apresentar e discutir a elaboração e a avaliação de material multimídia, destinado à orientação dos cuidadores de bebês com fissura labiopalatina, mais especificamente orientação sobre a velofaringe, palatoplastia primária e fala com relação às fissuras labiopalatinas. Métodos: A elaboração do material envolveu interdisciplinarmente as áreas de Fonoaudiologia, Odontologia e Arte. Permeados por princípios da a...περισσότερα »
Peripheral facial palsy: muscle activity in different onset times
Peripheral facial palsy: muscle activity in different onset times: RESUMO Objetivo : Avaliar, por meio da eletromiografia de superfície (EMGs), a atividade dos músculos risório e zigomático, durante a produção do sorriso voluntário, comparando os dados em dois grupos de indivíduos com tempos diferentes de início da paralisia facial periférica (PFP). Métodos : 140 adultos distribuídos em três grupos: G1 (35 indivíduos com início da PFP entre 0 e 3 meses); G2 (35 indivíduos com início da PFP entre 3 e 6 meses); GC (70 controles saudáveis). Todos os participantes foram submetidos à ava... περισσότερα »
Lead in Food Samples
A Method Using Liquid-Liquid Microextraction in a Dynamic System for Preconcentration and Determination of Lead in Food Samples: AbstractIn this paper, a method using liquid-liquid microextraction in a dynamic system combined with spectrophotometry was developed for preconcentration and determination of lead in samples of shrimp and oyster. In the procedure, a system is proposed in which the organic drop is maintained at the bottom of a glass tube, with the passage of a stream of aqueous solution, avoiding the use of a microsyringe. The method is based on the transfer of metal spec...περισσότερα »
Isolated language impairment as the primary presentation of sporadic Creutzfeldt Jakob Disease
Isolated language impairment as the primary presentation of sporadic Creutzfeldt Jakob Disease: Objectives Sporadic Creutzfeldt Jakob Disease (sCJD) is a neurodegenerative disorder that typically presents as a rapidly progressive encephalopathy associated with various neurological features, culminating in akinetic mutism and death. Atypical cases, presenting with an isolated focal may cause diagnostic confusion. We described a series of patients with sCJD presenting with isolated language impairment. Materials & methods We report a patient with sCJD referred to the NCJDRSU, who pres... περισσότερα »
p53 expression but not p16 INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma
in Kazakh population: Background: p16 INK4A expression has been used as a surrogate marker for human papillomavirus (HPV) infection in cervical cancer and head and neck cancer. p53 has also been reported as a feasible marker to identify HPV-positive oropharyngeal carcinoma and penile lesions. This study aimed to investigate p16 INK4A and p53 expression levels and their correlation with HPV status and clinical parameters in Kazakh patients with esophageal squamous cell carcinoma. Methods: Immunohistochemical expression of p16 INK4A and p53 were evaluated in 163 cases of es...περισσότερα »
Molecular genetics and epigenetics of nonfamilial (sporadic) parathyroid tumours
Molecular genetics and epigenetics of nonfamilial (sporadic) parathyroid tumours: Abstract Primary hyperparathyroidism (pHPT) is a common endocrine disease characterized by excessive secretion of parathyroid hormone and an increased level of serum calcium. Overall, 80–85% of pHPT cases are due to a benign, single parathyroid adenoma (PA), and 15% to multiglandular disease (multiple adenomas/hyperplasia). Parathyroid carcinoma (PC) is rare, accounting for <0.5–1% of pHPT cases. Secondary hyperparathyroidism (sHPT) is a complication of renal failure, with the development of parathyr...περισσότερα »
Endobronchial Ultrasound–guided Aspiration of an Endotracheal Bronchogenic Cyst: Case Report and Systematic Review of the Literature
Case Report and Systematic Review of the Literature: [image: image] The most common location of bronchogenic cysts is the mediastinum, adjacent to the major airways. Endotracheal bronchogenic cysts are rare and most present in infancy with respiratory failure. Although surgical resection has remained the treatment of choice, there is increasing interest in the management of these cysts with therapeutic aspiration alone. In this article, we describe a 68-year-old man with endotracheal bronchogenic cyst who was managed with endobronchial ultrasound–guided needle aspiration. We also ...περισσότερα »
Deep Sedation With Midazolam During Fiberoptic Bronchoscopy
A Prospective Analysis of the Efficacy and Complications Associated With Deep Sedation With Midazolam During Fiberoptic Bronchoscopy: [image: image]Background: Moderate sedation has been commonly used for fiberoptic bronchoscopy (FB). However, patients may find FB under moderate sedation to be unpleasant. We therefore examined whether deep sedation was a useful premedication for FB. Methods: We designed a prospective, randomized study using a patient questionnaire to address the perceptions of the procedures and complications of patients who underwent FB with deep sedation (deep sed... περισσότερα »
Awareness, Competencies, and Practice Patterns in Tracheobronchomalacia: A Survey of Pulmonologists
A Survey of Pulmonologists: [image: image] Background: Tracheobronchomalacia (TBM) is a disorder of expiratory central airway collapse. TBM is separate from excessive dynamic airway collapse. Historically TBM has lacked a universally accepted definition. No consensus recommendations on evaluation and management exist. We suspect these unresolved issues contribute to deficits in pulmonologists’ awareness and management of TBM. Methods: We created a 20-question survey obtaining information about overall awareness, knowledge base, competencies, and practice patterns in managing TBM.... περισσότερα »
Reconstruction of phylogenetic relationships in dermatomycete genus Trichophyton Malmsten 1848 based on ribosomal internal transcribed spacer region, partial 28S rRNA and beta-tubulin genes sequences
Summary *Trichophyton* spp. are important causative agents of superficial mycoses. The phylogeny of the genus and accurate strain identification, based on the ribosomal ITS region sequencing, are still under development. The present work is aimed at (i) inferring the genus phylogeny from partial ITS, LSU and *BT2* sequences (ii) description of ribosomal ITS region polymorphism in 15 strains of *Trichophyton interdigitale*. We performed DNA sequence-based species identification and phylogenetic analysis on 48 strains belonging to the genus *Trichophyton*. Phylogenetic relationships ... περισσότερα »
The efficacy and safety of clotrimazole vaginal tablet vs. oral fluconazole in treating severe vulvovaginal candidiasis
Summary To compare the efficacy and safety of two doses of clotrimazole vaginal tablet 500 mg with two doses of oral fluconazole 150 mg in treating severe vulvovaginal candidiasis (SVVC), 240 consecutive patients with SVVC were studied at the Department of Obstetrics and Gynaecology of Peking University Shenzhen Hospital between June 2014, and September 2015. Patients were randomly assigned in a 1 : 1 ratio to receive treatment with either two doses of clotrimazole vaginal tablet or two doses of oral fluconazole. The clinical cure rates in the clotrimazole group and the fluconazol... περισσότερα »
Development a diagnostic pan-dermatophyte TaqMan probe real-time PCR assay based on beta tubulin gene
Summary Early differentiation of dermatophytosis from other cutaneous mycoses is essential to avoid inaccurate therapy. DNA-based techniques including real-time PCR have increasingly been considered for detection of fungal elements in clinical specimens. In this study, after partial sequence analysis of beta tubulin (*BT2*) gene in 13 common and rare pathogenic dermatophyte species, a pan-dermatophyte primer and probe set was designed in a TaqMan probe-based PCR format. The sensitivity and specificity of the system was tested with 22 reference strains of dermatophytes, 234 positive...περισσότερα »
Cystic Pulmonary Myxoid Liposarcoma Mimicking Endobronchial Blood Clot
Cystic Pulmonary Myxoid Liposarcoma Mimicking Endobronchial Blood Clot: [image: image] A 71-year-old-man was transferred to our hospital in November 2012 for a bronchial artery embolization in the context of recurrent blood clots obstructing the left lower bronchus. Since June 2012, he had been explored for a cystic hypermetabolic lesion of the entire left lobe, and underwent 3 bronchoscopies and 2 computed tomography scan–guided biopsies, with no success. A fourth bronchoscopy enabled the extraction of a large blood clot (8×1.5 cm) that obstructed the left main bronchus. The pathol...περισσότερα »
Visualization of Cranial Nerves Using High-Definition Fiber Tractography.
Visualization of Cranial Nerves Using High-Definition Fiber Tractography.: BACKGROUND: Recent studies have demonstrated diffusion tensor imaging tractography of cranial nerves (CNs). Spatial and angular resolution, however, is limited with this modality. A substantial improvement in image resolution can be achieved with high-angle diffusion magnetic resonance imaging and atlas-based fiber tracking to provide detailed trajectories of CNs. OBJECTIVE: To use high-definition fiber tractography to identify CNs in healthy subjects and patients with brain tumors. METHODS: Five neurological...περισσότερα »
Concomitant Fundoplication with Gastrostomy: A Two-State Comparison Showing Continued Use of Reflux Medications.
Concomitant Fundoplication with Gastrostomy: A Two-State Comparison Showing Continued Use of Reflux Medications.: Objectives: We sought to determine if practice differences for fundoplication exist between two geographically distinct states, and to determine the reflux medication use pattern associated with concomitant fundoplication. Methods: A retrospective observational cohort study of children in Colorado (CO) and North Carolina (NC) insured by Medicaid from 2006-2008. Children who received a surgical gastrostomy during the study period were included, and our primary outcome mea... περισσότερα »
Assessing the Colonic Microbiota in Children
Effects of Sample Site and Bowel Preparation.: Objectives: Inflammatory bowel disease (IBD) states are associated with gastrointestinal dysbiosis. Mucosal biopsy sampling, retrieving the bacterial community that most directly interacts with the host, is an invasive procedure, and we hypothesize may be sufficiently approximated by other sampling methods. We investigate the relatedness of samples obtained by different methods and the effects of bowel preparation on the gastrointestinal community in a paediatric population. Methods: We recruited a cohort of patients undergoing colonosc...περισσότερα »
Cardiac Arrests Associated With Tracheal Intubations
in PICUs: A Multicenter Cohort Study.: [image: wk-health-logo.gif] Objectives: To determine the incidence and epidemiologic characteristics of cardiac arrests among tracheal intubations in PICUs. Design: Retrospective cohort study of prospectively collected data. Setting: Twenty-five diverse PICUs. Patients: Critically ill children requiring tracheal intubation in PICUs. Interventions: Tracheal intubation quality improvement data were prospectively collected for all initial tracheal intubations in 25 PICUs from July 2010 to March 2014 using National Emergency Airway Registry ... περισσότερα »
Cerebral Oximetry During Cardiac Arrest
A Multicenter Study of Neurologic Outcomes and Survival.: [image: wk-health-logo.gif] Objectives: Cardiac arrest is associated with morbidity and mortality because of cerebral ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation during resuscitation is associated with improved return of spontaneous circulation, survival, and neurologic outcomes at hospital discharge. We further examined the validity of regional cerebral oxygenation as a test to predict these outcomes. Design: Multicenter prospective study of in-hospital cardiac arrest. Setting... περισσότερα »
Cervicocephalic relocation test to evaluate cervical proprioception
Cervicocephalic relocation test to evaluate cervical proprioception in adolescent idiopathic scoliosis: Abstract PurposeAdolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine associated with disturbed postural control. Cervical proprioception participates in controlling orthostatic posture via its influence on head stabilization. We hypothesized that patients with AIS exhibit altered cervical proprioception. MethodsWe conducted a case–control study to evaluate cervical proprioception using the cervicocephalic relocation test (CRT) in 30 adolescents ... περισσότερα »
Detection of Staphylococcal Enterotoxins in Food Matrices
Toxins, Vol. 8, Pages 107: Review Over a 3-Year Period of European Union Proficiency Tests for Detection of Staphylococcal Enterotoxins in Food Matrices: Staphylococcal food poisoning outbreaks are a major cause of foodborne illnesses in Europe and their notifications have been mandatory since 2005. Even though the European regulation on microbiological criteria for food defines a criterion on staphylococcal enterotoxin (SE) only in cheese and dairy products, European Food Safety Authority (EFSA) data reported that various types of food matrices are involved in staphylococcal food p... περισσότερα »
Case file audit of Lidcombe program outcomes in a student-led stuttering clinic
10.3109/17549507.2016.1159336<br>Julia McCulloch from Speech via xlomafota13 on Inoreader http://ift.tt/1S9Qd5h via IFTTT
Case file audit of Lidcombe program outcomes in a student-led stuttering clinic
10.3109/17549507.2016.1159336<br>Julia McCulloch from Speech via xlomafota13 on Inoreader http://ift.tt/1S9Qd5h
Photoreactive and Metal-Platable Copolymer Inks for High-Throughput, Room-Temperature Printing of Flexible Metal Electrodes for Thin-Film Electronics
[image: Thumbnail image of graphical abstract] *Photoreactive and metal-platable copolymer inks* are reported for the first time to allow high-throughput printing of high-performance flexible electrodes at room temperature. This new copolymer ink accommodates various types of printing technologies, such as soft lithography molding, screen printing, and inkjet printing. Electronic devices including resistors, sensors, solar cells, and thin-film transistors fabricated with these printed electrodes show excellent electrical performance and mechanical flexibility. from Biomedical Eng... περισσότερα »
Enhancing Interfacial Bonding between Anisotropically Oriented Grains Using a Glue-Nanofiller for Advanced Li-Ion Battery Cathode
[image: Thumbnail image of graphical abstract] *Formation of a glue-nanofiller layer between grains, consisting of a middle-temperature spinel-like LixCoO2 phase,* reinforces the strength of the incoherent interfacial binding between anisotropically oriented grains by enhancing the face-to-face adhesion strength. The cathode treated with the glue-layer exhibits steady cycling performance at both room-temperature and 60 °C. These results represent a step forward in advanced lithium-ion battery via simple cathode coating. from Biomedical Engineering via xlomafota13 on Inoreader htt... περισσότερα »
Intermetallic NixMy (M = Ga and Sn) Nanocrystals: A Non-precious Metal Catalyst for Semi-Hydrogenation of Alkynes
[image: Thumbnail image of graphical abstract] *Intermetallic NixMy (M = Ga and Sn) nanocrystals with uniform particle size and controlled composition* are successfully synthesized via a solution-based co-reduction strategy. The as-obtained nanocrystals are crystalline and structurally ordered. The active site isolation and modified electronic structure are responsible for the excellent catalytic performance for alkyne semi-hydrogenation of the as-obtained non-precious catalysts. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1qophFn via IFTTT
Co-Occurrence of Chronic Spontaneous Urticaria with Immunoglobulin A Deficiency and Autoimmune Diseases
Co-Occurrence of Chronic Spontaneous Urticaria with Immunoglobulin A Deficiency and Autoimmune Diseases: *Background:* Immunoglobulin (Ig) A deficiency is a primary immunodeficiency in which autoimmunity is frequently observed. Thirty to fifty percent of patients with spontaneous chronic urticaria have autoantibodies that are able to cross-link FcεRI on mast cells and basophils. *Methods:* We investigated whether spontaneous chronic urticaria in patients with IgA deficiency meets the criteria for autoimmunity. Four patients were screened for positivity to a skin prick test and an au...περισσότερα »
Both atorvastatin and rosuvastatin are equally powerful statins and very effective in reducing the triglyceride and LDL-cholesterol levels. They are also effective in lowering hs-CRP and elevating vitamin D levels.
Atorvastatin versus rosuvastatin in non-diabetic patients with dyslipidemia: a comparative study: 2016-04-13T03-14-22Z *Source:* International Journal of Basic & Clinical Pharmacology Donepudi Pavan Kumar, K. Ravishankar. Background: Statins are recognized to be the first line of therapy for lowering cholesterol and have shown to reduce the morbidity and mortality caused by cardiovascular diseases. Atorvastatin and rosuvastatin are potent statins which can efficiently lower the cholesterol and triglyceride levels, we have thus undertaken this study to compare the efficacy of these... περισσότερα »
Oculopharyngeal muscular dystrophy (OPMD)
Haplotype analysis of oculopharyngeal muscular dystrophy (OPMD) locus in Yakutia: AbstractOculopharyngeal muscular dystrophy (OPMD) is a hereditary neuromuscular disease with autosomal dominant and rarely with autosomal recessive inheritance types. This study included 50 patients with a clinical diagnosis of OPMD, 23 asymptomatic carriers of the mutation from 45 unrelated families, and 56 healthy relatives, as well as population samples of four ethnic groups of Yakutia: Yakuts, Evens, Evenks, Yukaghirs. It was found that the cause of OPMD development in all investigated families i...περισσότερα »
Allergic Contact Dermatitis Caused by P-Tert-Butylphenol-Formaldehyde Resin in Orthopedic Braces
Allergic Contact Dermatitis Caused by P-Tert-Butylphenol-Formaldehyde Resin in Orthopedic Braces: Abstract P-tert-butylphenol-formaldehyde resin is a widely used adhesive chemical. It is used in a broad range of products and should be kept in mind when encountering children with suspected allergic contact dermatitis. We present a girl who developed contact allergy to p-tert-butylphenol-formaldehyde resin used in orthopedic braces.
Mycophenolate Mofetil and Mood Changes in Children with Skin Disorders
Mycophenolate Mofetil and Mood Changes in Children with Skin Disorders: Abstract The Risk Evaluation and Mitigation Strategy program that the U.S. Food and Drug Administration has mandated has intensified the counseling associated with prescribing mycophenolate mofetil (MMF), because of its teratogenicity. In this brief report, two children are described who were prescribed MMF and within weeks developed psychiatric symptoms, with rapid resolution after discontinuation of the medication and no recurrence over 4 years of follow-up. Mood disorders are a rare but possible side effect t... περισσότερα »
Hydroxyurea-induced Squamous Dysplasia
Ingenol mebutate in the treatment of ‘Hydroxyurea-induced Squamous Dysplasia’: a single centre experience: Abstract Background ‘Hydroxyurea-induced Squamous Dysplasia’ (HISD) is a cutaneous side-effect related to chronic oral treatment with Hydroxyurea. Ingenol mebutate gel is a topical drug approved for the treatment of multiple, non-hypertrophic actinic keratoses (AK) localized within a limited cancerization field. Since HISD may be considered as a drug-induced variant of classic AK, ingenol mebutate is likely to have therapeutic effects. Objectives The aim of this study was to ev... περισσότερα »
Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (HPV), particularly subtypes 13 and 32.
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13: Abstract Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (HPV), particularly subtypes 13 and 32. The disease typically presents in young Native American patients and is characterized by multiple asymptomatic papules and nodules on the oral mucosa, lips, tongue, and gingiva. The factors that determine susceptibility to FEH are unknown, but the ethnic and geographi...περισσότερα »
Case file audit of Lidcombe program outcomes in a student-led stuttering clinic
10.3109/17549507.2016.1159336<br>Julia McCulloch from #ENT via xlomafota13 on Inoreader http://ift.tt/1S9Qd5h via IFTTT
The use of fractional exhaled nitric oxide is valuable in select asthmatic patients.
Purpose of review: Clinical management of asthma is challenging and measuring fractional exhaled nitric oxide (FeNO) can be another tool to assist in meeting this challenge. Recent findings: Asthma is a heterogeneous condition. There are many different phenotypes. FeNO can help the physician identify which patients have eosinophilic inflammation and would potentially respond to corticosteroid therapy. Summary: FeNO is a complement to standard asthma care. FeNO can be used in the initial diagnosis of asthma and aid in stratification of which patients would be steroid responsive but a...περισσότερα »
Gluten sensitivity: fact or fashion statement?.
Purpose of review: In recent years, the concern over food sensitivities in general and gluten intolerance in particular has sharply increased. Patients and medical providers are awash in various claims about the potential implications of including or excluding gluten from the diet. Recent findings: Three main conditions are described with respect to gluten: wheat allergy, celiac disease, and nonceliac gluten sensitivity (NCGS). Wheat allergy is a type 1 hypersensitivity reaction to nongluten proteins within wheat. Celiac disease is an autoimmune reaction to the gluten protein result... περισσότερα »
The use of fractional exhaled nitric oxide is valuable in select asthmatic patients.
Purpose of review: Clinical management of asthma is challenging and measuring fractional exhaled nitric oxide (FeNO) can be another tool to assist in meeting this challenge. Recent findings: Asthma is a heterogeneous condition. There are many different phenotypes. FeNO can help the physician identify which patients have eosinophilic inflammation and would potentially respond to corticosteroid therapy. Summary: FeNO is a complement to standard asthma care. FeNO can be used in the initial diagnosis of asthma and aid in stratification of which patients would be steroid responsive but a...περισσότερα »
Gluten sensitivity: fact or fashion statement?.
Purpose of review: In recent years, the concern over food sensitivities in general and gluten intolerance in particular has sharply increased. Patients and medical providers are awash in various claims about the potential implications of including or excluding gluten from the diet. Recent findings: Three main conditions are described with respect to gluten: wheat allergy, celiac disease, and nonceliac gluten sensitivity (NCGS). Wheat allergy is a type 1 hypersensitivity reaction to nongluten proteins within wheat. Celiac disease is an autoimmune reaction to the gluten protein result... περισσότερα »
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
Abstract Objectives Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and methods Human macrophage-like U937 cells were co-inoculated with oral cancer SAS cells in a noncontact transwell coculture system. ...περισσότερα »
In vitro abrasion of resin-coated highly viscous glass ionomer cements: a confocal laser scanning microscopy study
Abstract Objectives The aim of this study was to evaluate the effect of resin coating on the wear depth of highly viscous glass ionomer cements (HVGICs) after 40,000 cycles, corresponding to over 8 years of tooth brushing. Materials and methods A resin composite (Gradia Direct Posterior), two HVGICs (EQUIA Fil and Riva Self Cure), a resin coating (EQUIA Coat) and a conventional varnish (Fuji Varnish) were used in the study. The control groups were the resin composite group and the non-coated HVGICs groups. Samples (*n* = 8) were produced in flat plastic moulds at 23 ± 1 °C and sto...περισσότερα »
Cachexia induces head and neck changes in locally advanced oropharyngeal carcinoma during definitive cisplatin and image-guided volumetric-modulated arc radiation therapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Cachexia induces head and neck changes in locally advanced oropharyngeal carcinoma during definitive cisplatin and image-guided volumetric-modulated arc radiation therapy European Journal of Clinical Nutrition advance online publication, April 13 2016. doi:10.1038/ejcn.2016.61 Authors: R Mazzola, F Ricchetti, A Fiorentino, G Di Paola, S Fersino, N Giaj Levra, R Ruggieri & F Alongi from #Medicine-SfakianakisAlexandros via […]
Documentation of the dietetic care process: developing a sectoral, tailored system
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Documentation of the dietetic care process: developing a sectoral, tailored system European Journal of Clinical Nutrition advance online publication, April 13 2016. doi:10.1038/ejcn.2016.62 Authors: S Rachman-Elbaum, B S Porat-Katz, J Kachal & A H Stark from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NnXb25 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
GOCS cohort: children’s eating behavior scores and BMI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
GOCS cohort: children’s eating behavior scores and BMI European Journal of Clinical Nutrition advance online publication, April 13 2016. doi:10.1038/ejcn.2016.18 Authors: U Sánchez, G Weisstaub, J L Santos, C Corvalán & R Uauy from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25ZvqbS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Toxins, Vol. 8, Pages 110: The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus. This molecule is used in biotechnology and has biomedical potential related to its anti-parasitic effect. A pseudo wild-type variant, rShPI-1A, with additional residues at the N- and C-terminal, has a similar three-dimensional structure and […]
Viruses, Vol. 8, Pages 97: Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
mRNA translation requires the ordered assembly of translation initiation factors and ribosomal subunits on a transcript. Host signaling pathways regulate each step in this process to match levels of protein synthesis to environmental cues. In response to infection, cells activate multiple defenses that limit viral protein synthesis, which viruses must counteract to successfully replicate. Human […]
Brain Sciences, Vol. 6, Pages 13: Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Perineuronal nets (PNNs) are specialized extracellular matrix molecules that are associated with the closing of the critical period, among other functions. In the adult brain, PNNs surround specific types of neurons, however the expression of PNNs in the auditory system of the mouse, particularly at the level of the midbrain and forebrain, has not been […]
Glucuronidation of mono(2-ethylhexyl) phthalate in humans: roles of hepatic and intestinal UDP-glucuronosyltransferases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Abstract Mono(2-ethylhexyl) phthalate (MEHP) is an active metabolite of di(2-ethylhexyl) phthalate (DEHP), which is an endocrine-disrupting chemical. In the present study, MEHP glucuronidation in humans was studied using recombinant UDP-glucuronosyltransferases (UGTs) and microsomes of the liver and intestine. Among the recombinant UGTs examined, UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, and UGT2B7 glucuronidated MEHP. The kinetics […]
An optimized staining technique for the detection of Gram positive and Gram negative bacteria within tissue
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Abstract Background Bacterial infections are a common clinical problem in both acute and chronic wounds. With growing concerns over antibiotic resistance, treatment of bacterial infections should only occur after positive diagnosis. Currently, diagnosis is delayed due to lengthy culturing methods which may also fail to identify the presence of bacteria. While newer costly bacterial identification […]
Integrated health messaging for multiple neglected zoonoses : approaches, challenges and opportunities in Morocco
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis […]
Diagnostics, Vol. 6, Pages 15: Reliability of Various Measurement Stations for Determining Plantar Fascia Thickness and Echogenicity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
This study aimed to determine the relative and absolute reliability of ultrasound (US) measurements of the thickness and echogenicity of the plantar fascia (PF) at different measurement stations along its length using a standardized protocol. Twelve healthy subjects (24 feet) were enrolled. The PF was imaged in the longitudinal plane. Subjects were assessed twice to […]
Propranolol for Preoperative Management of a Large Infantile Hemangioma
Propranolol for Preoperative Management of a Large Infantile Hemangioma: Abstract Infantile hemangiomas (IHs) are common vascular tumors that typically follow a predictable pattern of rapid proliferation followed by gradual involution. Although most do not require treatment, some large or difficult IHs do, with medical and surgical options available. Prior reports indicate the success of using propranolol, a nonselective β-blocker, to treat these lesions. This report will demonstrate the use of propranolol preoperatively to manage a large IH followed by surgical excision of the lesi...περισσότερα »
Effects of Selenium and Cadmium on Ion Profiles in the Brains
of Chickens: AbstractAntagonistic effects of selenium (Se) in cadmium (Cd)-induced toxicity have been frequently reported in previous studies. However, little was known about the interactions of Se and Cd on ion profiles in the brains of poultry. The aim of this study was to investigate the interaction between Se and Cd in the ion profile of the chicken brain. In the present study, a total of 128 laying hens were fed a Se-, Cd-, or Se + Cd-supplemented diet for 90 days. Levels of 28 ions were detected in chicken brains using ICP-MS. We found that Cd exposure significantly increas... περισσότερα »
Urachal Carcinoma with Choroidal, Lung, Lymph Node, Adrenal, Mammary, and Bone Metastases and Peritoneal Carcinomatosis Showing Partial Response after Chemotherapy Treatment with a Modified Docetaxel, Cisplatin and 5-Fluorouracil Regimen
Urachal Carcinoma with Choroidal, Lung, Lymph Node, Adrenal, Mammary, and Bone Metastases and Peritoneal Carcinomatosis Showing Partial Response after Chemotherapy Treatment with a Modified Docetaxel, Cisplatin and 5-Fluorouracil Regimen: Urachal carcinoma (UC) is a rare tumor mainly affecting middle-aged males. Metastases occur most frequently in lymph nodes and the lungs. There are no standard adjuvant and metastatic treatments. We report the case of a 36-year-old female with UC treated with partial cystectomy who relapsed 3 years after surgery with left choroidal, lung, mediastin... περισσότερα »
The role of thromboelastography in predicting bleeding risk
and guiding the administration of platelet transfusions in hematological patients: a cohort study: AbstractThe purpose of this study was to assess the accuracy of the parameters used in conventional hemostatic testing and thromboelastography (TEG) in predicting bleeding risk in patients with hematologic diseases. Patients diagnosed with a hematologic disease were divided into bleeding ( *n* = 125) and non-bleeding (*n* = 509) groups according to clinical signs and symptoms. Several parameters were measured in all patients via traditional hemostatic testing and TEG, including platel... περισσότερα »
Regional disparities in hospitalization charges for patients undergoing craniotomy
for tumor resection in New York State: correlation with outcomes: AbstractThere is increasing regulatory pressure for cost containment in neuro-oncology, and rationalization of the observed regional disparities. We investigated the presence of such disparities in New York State and examined the impact of risk adjustment on the magnitude of this variation. We performed a cohort study involving patients with brain tumors (gliomas, metastases, or meningiomas), who underwent craniotomy for resection from 2009 to 2013, and were registered in the Statewide Planning and Research Cooperat...περισσότερα »
Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors
Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors: by Carolyn S. Dewa, Lucy Trojanowski, Sietske J. Tamminga, Jolie Ringash, Maurene McQuestion, Jeffrey S. Hoch Purpose The purpose of this exploratory and descriptive study is to contribute to the sparse return-to-work literature on head and neck cancer (HNC) survivors. Interview participants were asked to reflect upon their work-related experience with cancer by answering two specific questions: (1) What advice would you give someone who has been newly diagnosed with head and neck cancer...περισσότερα »
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
Abstract Objectives Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and methods Human macrophage-like U937 cells were co-inoculated with oral cancer SAS cells in a noncontact transwell coculture system. ...περισσότερα »
In vitro abrasion of resin-coated highly viscous glass ionomer cements: a confocal laser scanning microscopy study
Abstract Objectives The aim of this study was to evaluate the effect of resin coating on the wear depth of highly viscous glass ionomer cements (HVGICs) after 40,000 cycles, corresponding to over 8 years of tooth brushing. Materials and methods A resin composite (Gradia Direct Posterior), two HVGICs (EQUIA Fil and Riva Self Cure), a resin coating (EQUIA Coat) and a conventional varnish (Fuji Varnish) were used in the study. The control groups were the resin composite group and the non-coated HVGICs groups. Samples (*n* = 8) were produced in flat plastic moulds at 23 ± 1 °C and sto...περισσότερα »
Central nervous system tumors
Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross-sectional study: Abstract Background Anxiety and depression have been identified as common psychological distresses faced by the majority of patients with cancer. However, no studies have investigated the relationship between positive psychological variables (hope, optimism and general self-efficacy) and anxiety and depression among patients with central nervous system (CNS) tumors in China. Our hypothesis is that the patients with... περισσότερα »
Are genetic tests informative in predicting food allergy?.
Are genetic tests informative in predicting food allergy?.: Purpose of review: Food allergy is common among children and adults worldwide. Recent studies have improved our understanding of the genetic mechanism of food allergy and further studies may result in clinical application through genetic testing. Recent findings: Genetic factors are important in the development of food allergy. An increasing number of genes have been associated with food allergy in recent years. These include mutations and variant in the filaggrin gene, the association of human leukocyte antigen DR and DQ ... περισσότερα »
Food allergy quality of life and living with food allergy.
'Doctor, my family life is being destroyed': food allergy quality of life and living with food allergy.: Purpose of review: Food allergy quality of life (QoL) has emerged as a key outcome to understand how food-allergic individuals and their families live with disease. Food allergy QoL has been measured since the early 2000's, but in the past 10-12 years, the advent of disease-specific indices has better defined the daily psychological burden of living with disease, which is distinct from measuring quality life in other chronic illnesses where affected patients suffer from more physi... περισσότερα »
Absorbable Versus Nonabsorbable Sutures for Skin Closure
A Meta-analysis of Randomized Controlled Trials: [image: image] Background: Prior studies focused on skin closure using absorbable or nonabsorbable sutures involved small samples and produced conflicting results. The optimal method of skin closure still remains unclear. Objective: This study aimed to compare the outcomes of absorbable versus nonabsorbable sutures for skin closure. Methods: A meta-analysis was performed in randomized controlled trials (RCTs) that compared outcomes of absorbable versus nonabsorbable sutures for skin closure. Results: A total of 1748 patients in 19 ...περισσότερα »
Lateral Arm Free Flap With Preservation of the Posterior Antebrachial Cutaneous Nerve
Lateral Arm Free Flap With Preservation of the Posterior Antebrachial Cutaneous Nerve: [image: image]Abstract: The lateral arm free flap offers many advantages in reconstruction of soft tissue defect and reconstruction of extremities. However, this free flap is associated with sensory loss at the posterior forearm due to injury of the posterior antebrachial cutaneous nerve (PABCN). The PABCN-sparing lateral arm free flaps were performed in 19 patients with various soft tissue defects of the extremity, and the outcomes of free flap reconstructions using this modification are evaluate... περισσότερα »
Is Propranolol Safe and Effective for Outpatient Use for Infantile Hemangioma? A Prospective Study of 679 Cases From One Center in China
Is Propranolol Safe and Effective for Outpatient Use for Infantile Hemangioma? A Prospective Study of 679 Cases From One Center in China: Background: The protocol for the treatment of infantile hemangioma with propranolol varies among different clinical centers. Methods: Six hundred seventy-nine patients who were 1 to 12 months old were recruited in this prospective study to receive propranolol treatment. The response to the propranolol therapy was classified as 4 levels. The results were primarily evaluated using color Doppler ultrasound examinations before and after propranolol t... περισσότερα »
Scapular Bone Grafts: Good Options for Craniofacial Defects?
Scapular Bone Grafts: Good Options for Craniofacial Defects?: [image: image]Introduction: There is still no consensus on the ideal material to be used in craniofacial defects. Autogenous bone grafts are mostly preferred owing to their use with fewer complications. The aim of this study was to evaluate whether the scapular bone graft can be used with equal or more advantages to other bone graft resources in orbital, maxillary sinus front wall, and frontal bone defects. Patients and Methods: Twenty-four orbital, maxillary sinus front wall, and frontal bone defects were reconstructed w... περισσότερα »
Modified Extracorporeal Septoplasty
: Functional Results at 6-Year Follow-up: [image: image]Background: Septal deviations represent a major cause of aesthetic disorders and respiratory obstruction. The traditional septoplasty techniques may often be inadequate to treat severe deviations. Recently, we described a modified extracorporeal septoplasty approach based on partial resection of the cartilaginous septum, with preservation of a superocaudal L-strut measuring approximately 0.5 cm in height. At 6-month follow-up, we demonstrated this technique to be functionally and aesthetically effective in addressing mild to se...περισσότερα »
Free Flap Monitoring Using Near-Infrared Spectroscopy
A Systemic Review: [image: image]Background: Although free flaps have become a reliable technique, vascular occlusion remains a significant risk. Flap survival is closely linked to the time interval between the onset and surgical repair of a microvascular problem. The newly emerged near-infrared spectroscopy (NIRS) shows the characteristics of being noninvasive, continuous, easy to use, objective, and immediately reflective, possibly making it an ideal candidate for postoperative flap monitoring. Methods: A systemic review was conducted to determine the clinical value of NIRS in th...περισσότερα »
The Hypoplastic Pixie Earlobe Deformity: V-Y Advancement Flap and Dermofat Graft
A Novel Method for Correction of the Hypoplastic Pixie Earlobe Deformity: V-Y Advancement Flap and Dermofat Graft: [image: image]Abstract: Pixie ear deformity is a condition in which the inferior edge of the helix of the ear is attached to the cheek without a convolutional notch at the ear lobule-cheek junction. Numerous surgical techniques have been proposed to correct pixie earlobe deformities. However, several of these techniques result in anterior or inferior scars of the ear lobules or dog-ear deformities. Such visible scarring detracts from the esthetics of the ear lobule. We... περισσότερα »
Ecchymosis in Rhinoplasty Surgery
Perioperative Arnica montana for Reduction of Ecchymosis in Rhinoplasty Surgery: [image: image]Background: Studies of homeopathic therapies to decrease postrhinoplasty ecchymosis have previously used subjective measurements, limiting their clinical significance. Recently, Arnica montana was shown to decrease postoperative ecchymosis after rhytidectomy, using an objective measuring tool. We believe that oral A. montana, given perioperatively, can be objectively shown to reduce extent and intensity of postoperative ecchymosis in rhinoplasty surgery. Methods: Subjects scheduled for ...περισσότερα »
Gluten sensitivity
fact or fashion statement?.: Purpose of review: In recent years, the concern over food sensitivities in general and gluten intolerance in particular has sharply increased. Patients and medical providers are awash in various claims about the potential implications of including or excluding gluten from the diet. Recent findings: Three main conditions are described with respect to gluten: wheat allergy, celiac disease, and nonceliac gluten sensitivity (NCGS). Wheat allergy is a type 1 hypersensitivity reaction to nongluten proteins within wheat. Celiac disease is an autoimmune reactio... περισσότερα »
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Abstract Objectives Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and methods Human macrophage-like U937 cells were co-inoculated with oral cancer SAS cells in a noncontact transwell coculture system. ...περισσότερα »
The use of fractional exhaled nitric oxide is valuable in select asthmatic patients.
The use of fractional exhaled nitric oxide is valuable in select asthmatic patients.: Purpose of review: Clinical management of asthma is challenging and measuring fractional exhaled nitric oxide (FeNO) can be another tool to assist in meeting this challenge. Recent findings: Asthma is a heterogeneous condition. There are many different phenotypes. FeNO can help the physician identify which patients have eosinophilic inflammation and would potentially respond to corticosteroid therapy. Summary: FeNO is a complement to standard asthma care. FeNO can be used in the initial diagnosis ... περισσότερα »
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells: Abstract ObjectivesAdvanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and met... περισσότερα »
Self-Fitting Hearing Aids
Status Quo and Future Predictions: A self-contained, self-fitting hearing aid (SFHA) is a device that enables the user to perform both threshold measurements leading to a prescribed hearing aid setting and fine-tuning, without the need for audiological support or access to other equipment. The SFHA has been proposed as a potential solution to address unmet hearing health care in developing countries and remote locations in the developed world and is considered a means to lower cost and increase uptake of hearing aids in developed countries. This article reviews the status of the S... περισσότερα »
Medullary Thyroid Cancer Report – Therapeutics Development Pipeline Review, H1 2016 – Research and Markets – Business Wire (press release)
Medullary Thyroid Cancer Report – Therapeutics Development Pipeline Review, H1 2016 – Research and Markets Business Wire (press release) This report provides comprehensive information on the therapeutic development for Medullary Thyroid Cancer, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration … What Is Thyroid… Continue reading Medullary Thyroid Cancer Report – Therapeutics Development Pipeline Review, H1 2016 – Research and Markets – Business Wire (press release)
Brain Sciences, Vol. 6, Pages 13: Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex
Perineuronal nets (PNNs) are specialized extracellular matrix molecules that are associated with the closing of the critical period, among other functions. In the adult brain, PNNs surround specific types of neurons, however the expression of PNNs in the auditory system of the mouse, particularly at the level of the midbrain and forebrain, has not been… Continue reading Brain Sciences, Vol. 6, Pages 13: Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex
IJMS, Vol. 17, Pages 553: Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic
We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we… Continue reading IJMS, Vol. 17, Pages 553: Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic
Treatment Satisfaction in Psoriasis: Development and Use of the PsoSat Patient Questionnaire in a Cross-Sectional Study
Introduction: Evidence supports the potential value of matching patient preferences to treatment recommendations. The aim of the study was to design and validate a questionnaire on treatment satisfaction for clinical decision-making. Methods: We performed a comprehensive literature search identifying measurable indicators. The complete item pool was condensed to a core set by a multidisciplinary expert… Continue reading Treatment Satisfaction in Psoriasis: Development and Use of the PsoSat Patient Questionnaire in a Cross-Sectional Study
Integrated health messaging for multiple neglected zoonoses : approaches, challenges and opportunities in Morocco
Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis… Continue reading Integrated health messaging for multiple neglected zoonoses : approaches, challenges and opportunities in Morocco
Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and 2) women… Continue reading Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugates in mouse tumor models
Publication date: 10 May 2016 Source:Journal of Controlled Release, Volume 229 Author(s): Yosi Shamay, Moran Golan, Dalia Tyomkin, Ayelet David Polymer–drug conjugates that can actively target the tumor vasculature have emerged as an attractive technology for improving the therapeutic efficacy of cytotoxic drugs. We have recently provided, for the first time, in vivo evidence showing… Continue reading Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugates in mouse tumor models
Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response
Publication date: 28 May 2016 Source:Journal of Controlled Release, Volume 230 Author(s): Peng Zhang, Priyesh Jain, Caroline Tsao, Andrew Sinclair, Fang Sun, Hsiang-Chieh Hung, Tao Bai, Kan Wu, Shaoyi Jiang Butyrylcholinesterase (BChE) is the most promising bioscavenger candidate to treat or prevent organophosphate (OP) poisoning. However, the clinical application of BChE is limited by two… Continue reading Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response
Preserving viability of Lactobacillus rhamnosus GG in vitro and in vivo by a new encapsulation system
Publication date: 28 May 2016 Source:Journal of Controlled Release, Volume 230 Author(s): Ran Li, Yufeng Zhang, D. Brent Polk, Peggy M. Tomasula, Fang Yan, LinShu Liu Probiotics have shown beneficial effects on health and prevention of diseases in humans. However, a concern for application of probiotics is the loss of viability during storage and gastrointestinal… Continue reading Preserving viability of Lactobacillus rhamnosus GG in vitro and in vivo by a new encapsulation system
IJMS, Vol. 17, Pages 553: Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we […]
Treatment Satisfaction in Psoriasis: Development and Use of the PsoSat Patient Questionnaire in a Cross-Sectional Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Introduction: Evidence supports the potential value of matching patient preferences to treatment recommendations. The aim of the study was to design and validate a questionnaire on treatment satisfaction for clinical decision-making. Methods: We performed a comprehensive literature search identifying measurable indicators. The complete item pool was condensed to a core set by a multidisciplinary expert […]
Integrated health messaging for multiple neglected zoonoses : approaches, challenges and opportunities in Morocco
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis […]
Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and 2) women […]
Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugates in mouse tumor models
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Publication date: 10 May 2016 Source:Journal of Controlled Release, Volume 229 Author(s): Yosi Shamay, Moran Golan, Dalia Tyomkin, Ayelet David Polymer–drug conjugates that can actively target the tumor vasculature have emerged as an attractive technology for improving the therapeutic efficacy of cytotoxic drugs. We have recently provided, for the first time, in vivo evidence showing […]
Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Publication date: 28 May 2016 Source:Journal of Controlled Release, Volume 230 Author(s): Peng Zhang, Priyesh Jain, Caroline Tsao, Andrew Sinclair, Fang Sun, Hsiang-Chieh Hung, Tao Bai, Kan Wu, Shaoyi Jiang Butyrylcholinesterase (BChE) is the most promising bioscavenger candidate to treat or prevent organophosphate (OP) poisoning. However, the clinical application of BChE is limited by two […]
Preserving viability of Lactobacillus rhamnosus GG in vitro and in vivo by a new encapsulation system
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Publication date: 28 May 2016 Source:Journal of Controlled Release, Volume 230 Author(s): Ran Li, Yufeng Zhang, D. Brent Polk, Peggy M. Tomasula, Fang Yan, LinShu Liu Probiotics have shown beneficial effects on health and prevention of diseases in humans. However, a concern for application of probiotics is the loss of viability during storage and gastrointestinal […]
The effect of undissolved air on isochoric freezing
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Publication date: Available online 10 April 2016 Source:Cryobiology Author(s): Pedro A. Perez, Jessica Preciado, Gary Carlson, Russ DeLonzor, Boris Rubinsky This study evaluates the effect of undissolved air on isochoric freezing of aqueous solutions. Isochoric freezing is concerned with freezing in a constant volume thermodynamic system. A possible advantage of the process is that it […]
JCM, Vol. 5, Pages 48: Long-Term Weight Change after Initiating Second-Generation Antidepressants
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of antidepressant medication and weight change at two years among adult patients with a new antidepressant treatment episode between January, 2006 and October, […]
JCM, Vol. 5, Pages 47: Management of Status Epilepticus in Children
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Status epilepticus is a common pediatric neurological emergency. Management includes prompt administration of appropriately selected anti-seizure medications, identification and treatment of seizure precipitant(s), as well as identification and management of associated systemic complications. This review discusses the definitions, classification, epidemiology and management of status epilepticus and refractory status epilepticus in children. from #ORL-AlexandrosSfakianakis via simeraentaxei […]
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
Abstract Objectives Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and methods Human macrophage-like U937 cells were co-inoculated with oral cancer SAS cells in a noncontact transwell coculture system. ...περισσότερα »
In vitro abrasion of resin-coated highly viscous glass ionomer cements: a confocal laser scanning microscopy study
Abstract Objectives The aim of this study was to evaluate the effect of resin coating on the wear depth of highly viscous glass ionomer cements (HVGICs) after 40,000 cycles, corresponding to over 8 years of tooth brushing. Materials and methods A resin composite (Gradia Direct Posterior), two HVGICs (EQUIA Fil and Riva Self Cure), a resin coating (EQUIA Coat) and a conventional varnish (Fuji Varnish) were used in the study. The control groups were the resin composite group and the non-coated HVGICs groups. Samples (*n* = 8) were produced in flat plastic moulds at 23 ± 1 °C and sto...περισσότερα »
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
AbstractObjectives Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb *Tripterygium wilfordii*, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether TPL exerts anticancer effects on the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC). Materials and methods Human macrophage-like U937 cells were co-inoculated with oral cancer SAS cells in a noncontact transwell coculture system. Cyt... περισσότερα »
In vitro abrasion of resin-coated highly viscous glass ionomer cements: a confocal laser scanning microscopy study
AbstractObjectives The aim of this study was to evaluate the effect of resin coating on the wear depth of highly viscous glass ionomer cements (HVGICs) after 40,000 cycles, corresponding to over 8 years of tooth brushing. Materials and methods A resin composite (Gradia Direct Posterior), two HVGICs (EQUIA Fil and Riva Self Cure), a resin coating (EQUIA Coat) and a conventional varnish (Fuji Varnish) were used in the study. The control groups were the resin composite group and the non-coated HVGICs groups. Samples (*n* = 8) were produced in flat plastic moulds at 23 ± 1 °C and stored...περισσότερα »
Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina
Publication date: Available online 13 April 2016 *Source:*Journal of Proteomics Author(s): Simeon L. Minic, Dragana Stanic-Vucinic, Jelena Vesic, Maja Krstic, Milan R. Nikolic, Tanja Cirkovic Velickovic C-phycocyanin, the major protein of cyanobacteria Spirulina, possesses significant antioxidant, anti-cancer, anti-inflammatory and immunomodulatory effects, ascribed to covalently attach linear tetrapyrrole chromophore phycocyanobilin. There are no literature data about structure and biological activities of released peptides with bound chromophore in C-phycocyanin digest. This study... περισσότερα »
Reducing the cost of semi-automated in-gel tryptic digestion and GeLC sample preparation for high-throughput proteomics
Publication date: Available online 13 April 2016 *Source:*Journal of Proteomics Author(s): Jayde E. Ruelcke, Dorothy Loo, Michelle M. Hill Peptide generation by trypsin digestion is typically the first step in mass spectrometry-based proteomics experiments, including 'bottom-up' discovery and targeted proteomics using multiple reaction monitoring. Manual tryptic digest and the subsequent clean-up steps can add variability even before the sample reaches the analytical platform. While specialized filter plates and tips have been designed for automated sample processing, the specialty ... περισσότερα »
Characterization of the orthodox Pinus occidentalis seed and pollen proteomes by using complementary gel-based and gel-free approaches
Publication date: Available online 12 April 2016 *Source:*Journal of Proteomics Author(s): Luis Rodríguez de Francisco, Ma. Cristina Romero-Rodríguez, Rafael M. Navarro-Cerrillo, Virgilio Miniño, Omar Perdomo, Jesús V. Jorrín-Novo This work presents an analysis of Pinus occidentalis pollen and seed proteomes, in which both gel-based and gel-free approaches have been used. Proteins were extracted from P. occidentalis seeds and pollen by using the TCA/acetone/phenol precipitation protocol, and protein extracts were subjected to 1- and 2-DE coupled to MALDI-TOF-TOF as well as to shotgu... περισσότερα »
Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and 2) women […]
Canine visceral leishmaniasis in the Northeast Region of Brazil
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Abstract Background Visceral leishmaniasis (VL) is a zoonosis that affects dogs and other mammals, including humans. Contact with dogs is a major risk factor for humans. This disease is endemic in several regions of Brazil. The aim of this study was to determine the prevalence of Leishmania spp. infection in dogs and to correlate it […]
Classification of forensically-relevant larvae according to instar in a closely related species of carrion beetles (Coleoptera: Silphidae: Silphinae)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Abstract Carrion beetle larvae of Necrodes littoralis (Linnaeus, 1758), Oiceoptoma thoracicum (Linnaeus, 1758), Thanatophilus sinuatus (Fabricius, 1775), and Thanatophilus rugosus (Linnaeus, 1758) (Silphidae: Silphinae) were studied to test the concept that a classifier of the subfamily level may be successfully used to classify larvae according to instar. Classifiers were created and validated using a linear […]
The effect of undissolved air on isochoric freezing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Publication date: Available online 10 April 2016 Source:Cryobiology Author(s): Pedro A. Perez, Jessica Preciado, Gary Carlson, Russ DeLonzor, Boris Rubinsky This study evaluates the effect of undissolved air on isochoric freezing of aqueous solutions. Isochoric freezing is concerned with freezing in a constant volume thermodynamic system. A possible advantage of the process is that it […]
Nosocomial infection control in healthcare settings: Protection against emerging infectious diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Abstract The Middle East respiratory syndrome (MERS) outbreak in Korea in 2015 may be attributable to poor nosocomial infection control procedures implemented. Strict infection control measures were taken in the hospital where an imported case with MERS was treated in southern China and 53 health care workers were confirmed to be MERS-CoV negative. Infection control […]
Postepy Hig Med Dosw 2016; 70:280-294 «PARP1 inhibitors: contemporary attempts at their use in anticancer therapy and future perspective»
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Current cancer therapies are based mainly on the use of compounds that cause DNA damage. Unfortunately, even the combination therapies do not give rewarding effects, due to the high efficiency of DNA damage repair mechanisms in tumor cells. Therefore, the present studies should be focused on proteins that are involved in DNA repair systems. Poly(ADP-ribose) […]
Postepy Hig Med Dosw 2016; 70:295-304 «Explaining the Decrease in Deaths from Cardiovascular Disease in Poland. The Top-Down Risk Assessment Approach, from Policy to Health Impact»
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Objective: The purpose of this paper was to assess the relations between policy and health outcome Setting: The CVD mortality rate in Poland over the past two decades has decreased by about 40%. It was the highest decrease among Central and Eastern European countries and also exceptional on a global scale. Design:Key determinants which can […]
Postepy Hig Med Dosw 2016; 70:305-312 «Markery zapalenia, aktywacja płytek krwi i zaburzenia krzepnięcia w chorobach zapalnych jelit»
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn’s disease. It is a group of chronic disorders characterized by inflammation of the gastrointestinal track with unknown etiology. Currently applied biomarkers include CRP, ESR, pANCA, ASCA, and fecal calprotectin. The etiopathogenesis of IBD is multifactorial. In patients with IBD in inflamed alimentary tract mucosa the number […]
The effect of undissolved air on isochoric freezing
Publication date: Available online 10 April 2016 Source:Cryobiology Author(s): Pedro A. Perez, Jessica Preciado, Gary Carlson, Russ DeLonzor, Boris Rubinsky This study evaluates the effect of undissolved air on isochoric freezing of aqueous solutions. Isochoric freezing is concerned with freezing in a constant volume thermodynamic system. A possible advantage of the process is that it… Continue reading The effect of undissolved air on isochoric freezing
JCM, Vol. 5, Pages 47: Management of Status Epilepticus in Children
Status epilepticus is a common pediatric neurological emergency. Management includes prompt administration of appropriately selected anti-seizure medications, identification and treatment of seizure precipitant(s), as well as identification and management of associated systemic complications. This review discusses the definitions, classification, epidemiology and management of status epilepticus and refractory status epilepticus in children. from #ORL-AlexandrosSfakianakis via simeraentaxei… Continue reading JCM, Vol. 5, Pages 47: Management of Status Epilepticus in Children
JCM, Vol. 5, Pages 48: Long-Term Weight Change after Initiating Second-Generation Antidepressants
(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of antidepressant medication and weight change at two years among adult patients with a new antidepressant treatment episode between January, 2006 and October,… Continue reading JCM, Vol. 5, Pages 48: Long-Term Weight Change after Initiating Second-Generation Antidepressants
Postepy Hig Med Dosw 2016; 70:280-294 «PARP1 inhibitors: contemporary attempts at their use in anticancer therapy and future perspective»
Current cancer therapies are based mainly on the use of compounds that cause DNA damage. Unfortunately, even the combination therapies do not give rewarding effects, due to the high efficiency of DNA damage repair mechanisms in tumor cells. Therefore, the present studies should be focused on proteins that are involved in DNA repair systems. Poly(ADP-ribose)… Continue reading Postepy Hig Med Dosw 2016; 70:280-294 «PARP1 inhibitors: contemporary attempts at their use in anticancer therapy and future perspective»
Postepy Hig Med Dosw 2016; 70:295-304 «Explaining the Decrease in Deaths from Cardiovascular Disease in Poland. The Top-Down Risk Assessment Approach, from Policy to Health Impact»
Objective: The purpose of this paper was to assess the relations between policy and health outcome Setting: The CVD mortality rate in Poland over the past two decades has decreased by about 40%. It was the highest decrease among Central and Eastern European countries and also exceptional on a global scale. Design:Key determinants which can… Continue reading Postepy Hig Med Dosw 2016; 70:295-304 «Explaining the Decrease in Deaths from Cardiovascular Disease in Poland. The Top-Down Risk Assessment Approach, from Policy to Health Impact»
Postepy Hig Med Dosw 2016; 70:305-312 «Markery zapalenia, aktywacja płytek krwi i zaburzenia krzepnięcia w chorobach zapalnych jelit»
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn’s disease. It is a group of chronic disorders characterized by inflammation of the gastrointestinal track with unknown etiology. Currently applied biomarkers include CRP, ESR, pANCA, ASCA, and fecal calprotectin. The etiopathogenesis of IBD is multifactorial. In patients with IBD in inflamed alimentary tract mucosa the number… Continue reading Postepy Hig Med Dosw 2016; 70:305-312 «Markery zapalenia, aktywacja płytek krwi i zaburzenia krzepnięcia w chorobach zapalnych jelit»
Atorvastatin versus rosuvastatin in non-diabetic patients with dyslipidemia: a comparative study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-04-13T03-14-22Z *Source:* International Journal of Basic & Clinical Pharmacology Donepudi Pavan Kumar, K. Ravishankar. Background: Statins are recognized to be the first line of therapy for lowering cholesterol and have shown to reduce the morbidity and mortality caused by cardiovascular diseases. Atorvastatin and rosuvastatin are potent statins which can efficiently lower the cholesterol and triglyceride levels, we have thus undertaken this study to compare the efficacy of these two statins in non-diabetic patients. Methods: 150 patients selected for the study, were over 18 ye...περισσότερα »
Effects of Short-Term Physical Activity Interventions on Simple and Choice Response Times
Objective. Response time (RT) is important for health and human performance and provides insight into cognitive processes. It deteriorates with age, is associated with chronic physical activity (PA), and improves with PA interventions. We investigated associations between the amount and type of PA undertaken and the rate of change in RT for low-active adults across the age range 18–63 yr. Methods. Insufficiently active adults were assigned to either a walking () or higher-intensity () exercise program conducted over 40 days. Active controls were also recruited (). Simple response t... περισσότερα »
Discogens Possessing Aryl Side Groups Synthesized by Suzuki Coupling of Triphenylene Triflates and Their Self-Organization Behavior
Abstract Pd-catalyzed Suzuki cross-coupling reactions between arylboronic acids and bromoarenes have been applied widely in the synthesis of liquid-crystalline materials. However, aryl triflate derivatives have been less used despite their high chemical tolerance, reactivity, and chemical accessibility. In this report, three series of discogens have been synthesized in good yields from appropriate triphenylene triflate precursors by Suzuki coupling reactions with various commercial arylboronic acids (e.g., aryl = phenylene, thiophene, naphthalene, triarylamine, carbazole, and fluor... περισσότερα »
Concise Total Syntheses of Pyrido[4,3-b]carbazole Alkaloids Using Copper-Mediated 6π-Electrocyclization
Abstract Concise syntheses of 9-methoxyellipticine, 3,4-dihydroellipticine (µ-alkaloid D), 1,2,3,4-tetrahydroellipticine, 2-methyl-1,2,3,4-tetrahydroellipticine, olivacine, 3,4-dihydroolivacine, (±)-guatambuine, and (±)-janetine were developed starting from hexatriene intermediates readily obtained by Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborates. The route enables the facile construction of pyrido[4,3-*b*]carbazoles by Cu-catalyzed 6π-electrocyclization and subsequent transformation of the pyridocarbazole intermediates into pyrido[4,3-*b*]carbazole alk... περισσότερα »
Solvatochromic CuII-Containing Ionic Liquids with Ether Side Chains: Control of Solvent Response through Intramolecular Coordination
Abstract We reported previously that ionic liquids containing cationic solvatochromic metal–chelate complexes exhibit vapochromic and solvatochromic properties, changing color upon coordination of different solvents. To control the solvent response by intramolecular coordination, an ether side chain was introduced into the cation as an additional flexible coordination site, and ionic liquids of the formula [Cu(acac){Me2 NCH2CH2NMe(CH2)*n*OMe}][Tf2N] {[*1*][Tf2N]: *n* = 3, [*2*][Tf2N]: *n* = 4; acac = acetylacetonato, Tf2N = (F3CSO2)2N–} were synthesized. The melting points of [*1*]...περισσότερα »
Zinc Scorpionate Complexes with a Hybrid (Thiopyridazinyl)(thiomethimidazolyl)borate Ligand
Abstract Zinc complexes with the mixed scorpionate ligand (6-*tert*-butyl-3-thiopyridazinyl)bis(2-thiomethimidazolyl)borate (PnBm) have been synthesized and characterized by NMR and IR spectroscopy. The complexes, with the general formula [(PnBm)ZnX]2 [X = Br (*1a*), I (*1b*)], are dimeric in the solid state, as determined by single-crystal X-ray diffraction analyses. The zinc atoms are tetrahedrally coordinated by the halogen atom, two sulfur atoms of PnBm, and one sulfur atom from a bridging PnBm ligand. Variable-temperature 1H NMR spectroscopy indicated dimeric structures also i...περισσότερα »
Bio-Based Amides from Renewable Isosorbide by a Direct and Atom-Economic Boric Acid Amidation Methodology
Abstract The functionalization of bio-sourced isohexides has proved challenging over the last number of years, especially in polymer and medicinal chemistry. We report herein the synthesis of bio-based amido-isohexides by the known boric acid catalysed amidation reaction. The coupling reaction was successfully performed with aliphatic and aromatic carboxylic acids. The extension of the scope of the reaction to eight Boc-protected amino acids is also described, the products being obtained in moderate to good yields. A preliminary screening of these new potential organocatalysts was ... περισσότερα »
Clinical Practice of Adjuvant Chemotherapy in Patients with Early-Stage Epithelial Ovarian Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. Methods: All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients that received adjuvant chemotherapy was determined as well as […]
Distribution of growth hormone-responsive cells in the mouse brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Growth hormone (GH) exerts important biological effects primarily related to growth and metabolism. However, the role of GH signaling in the brain is still elusive. To better understand GH functions in the brain, we mapped the distribution of GH-responsive cells and identified the receptors involved in GH central effects. For this purpose, mice received […]
The use of fractional exhaled nitric oxide is valuable in select asthmatic patients.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose of review: Clinical management of asthma is challenging and measuring fractional exhaled nitric oxide (FeNO) can be another tool to assist in meeting this challenge. Recent findings: Asthma is a heterogeneous condition. There are many different phenotypes. FeNO can help the physician identify which patients have eosinophilic inflammation and would potentially respond to corticosteroid […]
Gluten sensitivity: fact or fashion statement?.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose of review: In recent years, the concern over food sensitivities in general and gluten intolerance in particular has sharply increased. Patients and medical providers are awash in various claims about the potential implications of including or excluding gluten from the diet. Recent findings: Three main conditions are described with respect to gluten: wheat allergy, […]
Revisiting the Potential of Alternating Repetition Time Balanced Steady-State Free Precession Imaging of the Abdomen at 3 T.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: The aim was to investigate the value of optimized 3-dimensional alternating repetition time balanced steady-state free precession (ATR-SSFP), as an alternative to conventional segmented balanced steady-state free precession (bSSFP) with fat suppression prepulse (FS-bSSFP), in single breath-hold abdominal magnetic resonance imaging at 3 T. Methods: Bloch simulations were performed to determine the optimal flip […]
Co-Occurrence of Chronic Spontaneous Urticaria with Immunoglobulin A Deficiency and Autoimmune Diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Immunoglobulin (Ig) A deficiency is a primary immunodeficiency in which autoimmunity is frequently observed. Thirty to fifty percent of patients with spontaneous chronic urticaria have autoantibodies that are able to cross-link FcεRI on mast cells and basophils. Methods: We investigated whether spontaneous chronic urticaria in patients with IgA deficiency meets the criteria for autoimmunity. […]
Fears rise over yellow fever’s next move
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Scientists warn vaccine stocks would be overwhelmed in the event of large urban outbreaks. Nature 532 155 doi: 10.1038/532155a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T3gqTa via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Schulterdystokie bringt Analsphinkter der Mutter in Gefahr
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Gesteigertes OASIS-Risiko Eine Schulterdystokie ist ein geburtshilflicher Notfall, bedrohlich zunächst einmal für das Kind. Doch auch die Mutter kann erheblichen Schaden nehmen, wenn die Fehleinstellung der Kindesschulter behoben werden muss. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TQGDqb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mapping the Knowledge Structure of Neonatal Hypoxic-Ischemic Encephalopathy Over the Past Decade: A Co-word Analysis Based on Keywords
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of this study was to analyze the knowledge structure and report the evolution of hypoxic-ischemic encephalopathy research over the past decade based on co-word analysis. Scientific publications focusing on neonatal hypoxic-ischemic encephalopathy were searched from the Web of Science database (January 2005 to December 2014). The keywords from these articles were extracted, and […]
Effects of Smart-Tablet-Based Neurofeedback Training on Cognitive Function in Children with Attention Problems
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We sought to determine whether smart-tablet-based neurofeedback could improve executive function—including attention, working memory, and self-regulation—in children with attention problems. Forty children (10-12 years old) with attention problems, as determined by ratings on the Conners Parent Rating Scale, were assigned to either a neurofeedback group that received 16 sessions or a control group. A comprehensive […]
Early onset scoliosis with intraspinal anomalies: management with growing rod
Abstract Objective To evaluate clinical and radiological outcomes of growing rod (GR) in the management of Early Onset Scoliosis (EOS) with intraspinal anomalies. Background data The effect of repeated distractions following GR, in the presence of intraspinal anomalies has not been studied. Methods During 2007–2012, 46 patients underwent fusionless surgery. Out of these 46 patients, 13 patients had one or more intraspinal anomalies. 11 patients had undergone prior neurosurgical procedure while 2 (filum terminale lipoma and syringomyelia) did not. A total of 88 procedures were con...περισσότερα »
Hemivertebra resection with posterior unilateral intervertebral fusion and transpedicular fixation for congenital scoliosis: results with at least 3 years of follow-up
Abstract Purpose The main treatment for congenital scoliosis is posterior hemivertebra resection with bilateral transpedicular fixation. Reports describing posterior unilateral intervertebral fusion and transpedicular screw fixation are rare, with no long-term follow-up results, especially in older children. Retrospective analysis of the long-term outcomes of unilateral fusion and fixation after hemivertebra resection for congenital scoliosis. Methods From April 2004 to May 2012, 19 consecutive cases (12 males; age range 2.3–13.4 years) of congenital scoliosis treated by hemiverte... περισσότερα »
Variable radiation sensitivity among liver metastases
Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumours maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1N80wrr via IFTTT
Mathematical model of immune evasion by tumour cells could help focus treatments
Mathematicians and physicians at the University of Bonn have developed a new model for immunotherapy of cancer, and their method could help to develop new treatment strategies and to understand why some approaches do not work with certain tumours. The… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1S634Dd via IFTTT
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