Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 19 Απριλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,April 19th,2016,a


Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.* J Biophotonics. 2016 Apr 18; Authors: Dias Schalch T, Porta Santos Fernandes K, Costa-Rodrigues J, Pereira Garcia M, Agnelli Mesquita-Ferrari R, Kalil Bussadori S, Fernandes MH Abstract The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (P...περισσότερα »

In-Vitro Development of A Mucocutaneous Junction for Lip Reconstruction

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Gurkan Rasit Bayar, Shiuhyang Kuo, Cynthia L. Marcelo, Stephen E. Feinberg PurposePresentation of a simple and reproducible technique to create, in vitro, a construct containing a mucocutaneous junction (MCJ) with a transitional zone (vermillion) for fabrication of a microvascular prelaminated flap for use in lip reconstruction.Material and MethodsCultured primary human skin keratinocytes and oral mucosal epithelial cells at premixed ratios of 50% skin-50% oral, 25% skin-75... περισσότερα »

Linear Epidermal Nevus: A Case Report With Oral and Facial Manifestations

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Christopher Maly, Heather Olmo, Steven Stokes, Hank Cole A 20 year old male presented to the Oral and Maxillofacial Surgery Department for evaluation and treatment of his dentiofacial deformity. Upon examination, it was noted that he had marked hemi-facial hyperpigmented papillomatous lesions covering the upper and middle thirds of right-side of his face extending to the right upper lid. Of note, he also had extensive intraoral involvement. These features were highly suggest... περισσότερα »

Comparative assessment of ibuprofen and etodolac in edema, trismus and pain in lower third molar surgery: A randomized, clinical trial

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Júlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi PurposeTo compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus following extraction of lower-third molars.MethodsTwenty young adults with two impacted "mandibular-third" molars (in similar positions) were selected for the study. Patients were randomly assigned either to the IBU group (IBU: 600 mg three times a day for 3 days) or to the ET... περισσότερα »

Response to the Parkland 12-Minute Checklist Tracheostomy

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 18 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Jonathon S. Jundt from #ENT via xlomafota13 on Inoreader http://ift.tt/23W0kzN via IFTTT

The Production of Complement Clauses in Children With Language Impairment.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*The Production of Complement Clauses in Children With Language Impairment.* J Speech Lang Hear Res. 2016 Apr 18;:1-12 Authors: Steel G, Rose M, Eadie P Abstract Purpose: The purpose of this research was to provide a comprehensive description of complement-clause production in children with language impairment. Complement clauses were examined with respect to types of complement structure produced, verb use, and both semantic and syntactic accuracy. Method: A group of 17 children with language impairment (mean age = 6;10 [years; months]) was compared with a group of 17 younger chi... περισσότερα »

Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task.* J Speech Lang Hear Res. 2016 Apr 18;:1-13 Authors: Guo LY, Schneider P Abstract Purpose: To determine the diagnostic accuracy of the finite verb morphology composite (FVMC), number of errors per C-unit (Errors/CU), and percent grammatical C-units (PGCUs) in differentiating school-aged children with language impairment (LI) and those with typical language development (TL). Method: Participants were 61 six-year-olds (50 TL, 11 LI) and 67 eight-ye...περισσότερα »

The Association Between Parental Mean Length of Utterance and Language Outcomes in Children With Disabilities: A Correlational Meta-Analysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*The Association Between Parental Mean Length of Utterance and Language Outcomes in Children With Disabilities: A Correlational Meta-Analysis.* Am J Speech Lang Pathol. 2016 Apr 18;:1-12 Authors: Sandbank M, Yoder P Abstract Purpose: The purpose of this correlational meta-analysis was to examine the association between parental utterance length and language outcomes in children with disabilities and whether this association varies according to other child characteristics, such as age and disability type. This association can serve as a starting point for language intervention pra... περισσότερα »

Between-language repetition priming in antonym generation: evidence that translation-equivalent adjectives have shared conceptual representations across languages.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Between-language repetition priming in antonym generation: evidence that translation-equivalent adjectives have shared conceptual representations across languages.* Memory. 2016 Apr 18;:1-6 Authors: Taylor RS, Francis WS Abstract Previous literature has demonstrated conceptual repetition priming across languages in bilinguals. This between-language priming effect is taken as evidence that translation equivalents have shared conceptual representations across languages. However, the vast majority of this research has been conducted using only concrete nouns as stimuli. The presen...περισσότερα »

Infant-Directed Speech Is Consistent With Teaching.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Infant-Directed Speech Is Consistent With Teaching.* Psychol Rev. 2016 Apr 18; Authors: Eaves BS, Feldman NH, Griffiths TL, Shafto P Abstract Infant-directed speech (IDS) has distinctive properties that differ from adult-directed speech (ADS). Why it has these properties-and whether they are intended to facilitate language learning-is a matter of contention. We argue that much of this disagreement stems from lack of a formal, guiding theory of how phonetic categories should best be taught to infantlike learners. In the absence of such a theory, researchers have relied on intuiti... περισσότερα »

Development and reliability of the Functional Communication Classification System for children with cerebral palsy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Development and reliability of the Functional Communication Classification System for children with cerebral palsy.* Dev Med Child Neurol. 2016 Apr 17; Authors: Barty E, Caynes K, Johnston LM Abstract AIM: This paper describes the development, validation, and reliability of the Functional Communication Classification System (FCCS), designed to classify expressive communication skills of children with cerebral palsy (CP) aged 4 years and 5 years (between their fourth and sixth birthdays). METHOD: The Functional Communication Classification System (FCCS) was developed in 2006 using...περισσότερα »

Neural Basis of Language: An Overview of An Evolving Model.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
*Neural Basis of Language: An Overview of An Evolving Model.* Neurol Med Chir (Tokyo). 2016 Apr 16; Authors: Fujii M, Maesawa S, Ishiai S, Iwami K, Futamura M, Saito K Abstract The neural basis of language had been considered as a simple model consisting of the Broca's area, the Wernicke's area, and the arcuate fasciculus (AF) connecting the above two cortical areas. However, it has grown to a larger and more complex model based upon recent advancements in neuroscience such as precise imaging studies of aphasic patients, diffusion tensor imaging studies, functional magnetic resona... περισσότερα »

Evidence Base Update for Autism Spectrum Disorder.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Related Articles *Evidence Base Update for Autism Spectrum Disorder.* J Clin Child Adolesc Psychol. 2015;44(6):897-922 Authors: Smith T, Iadarola S Abstract This evidence base update examines the level of empirical support for interventions for children with autism spectrum disorder (ASD) younger than 5 years old. It focuses on research published since a previous review in this journal (Rogers & Vismara, 2008 ). We identified psychological or behavioral interventions that had been manualized and evaluated in either (a) experimental or quasi-experimental group studies or (b) syste... περισσότερα »

Speech myoclonus due to probable pregabalin adverse drug-reaction.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Speech myoclonus due to probable pregabalin adverse drug-reaction.* Parkinsonism Relat Disord. 2015 Jul;21(7):823-4 Authors: Olszewska DA, Chalissery AJ, Williams J, Lynch T, Smyth S PMID: 25956204 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1clvtXB via IFTTT

The impact of cochlear implantation on cognition in older adults: a systematic review of clinical evidence.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The impact of cochlear implantation on cognition in older adults: a systematic review of clinical evidence.* BMC Geriatr. 2015;15:16 Authors: Miller G, Miller C, Marrone N, Howe C, Fain M, Jacob A Abstract BACKGROUND: Hearing loss is the third most prevalent chronic condition faced by older adults and has been linked to difficulties in speech perception, activities of daily living, and social interaction. Recent studies have suggested a correlation between severity of hearing loss and a... περισσότερα »

Competition between rhythmic and linguistic organization in a sentence-rhythm Stroop task.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Related Articles *Competition between rhythmic and linguistic organization in a sentence-rhythm Stroop task.* Q J Exp Psychol (Hove). 2015;68(11):2243-54 Authors: Getz LM, Salona P, Yu M, Kubovy M Abstract We provide a test of Patel's [( 2003 ). Language, music, syntax and the brain. Nature Neuroscience, 6, 674-681] shared syntactic integration resources hypothesis by investigating the competition between determinants of rhythmic parsing and linguistic parsing using a sentence-rhythm Stroop task. We played five-note rhythm patterns in which each note is replaced with a spoken wo...περισσότερα »

Toxic epidermal necrolysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 55 δευτερόλεπτα
Related Articles *Toxic epidermal necrolysis.* Anaesthesiol Intensive Ther. 2015;47(3):257-62 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, are rare, life- -threatening diseases that are characterised by extensive epidermal detachment, erosion of mucous membranes and severe systemic symptoms. In the majority of cases, the development of symptoms can be attributed to the use of drugs; therefore, the disease pathology is thought to be caused by a severe adve... περισσότερα »

The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπτα
Related Articles *The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.* Anaesthesiol Intensive Ther. 2015;47(3):210-3 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Głowacka M, Ożóg-Zabolska I Abstract BACKGROUND: Toxic epidermal necrosis (TEN) is a severe and life-threatening syndrome manifesting as extensive necrosis of the epidermis and mucous membranes accompanied by systemic symptoms. The causative factor is exposure to drugs, such as sulphonamides, antiepileptic preparations, non-steroidal anti-inflammatory drugs and paracetamol. The mechanism leadin...περισσότερα »

Fine Tuning of a Type 1 Interferon Antagonist.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Fine Tuning of a Type 1 Interferon Antagonist.* PLoS One. 2015;10(7):e0130797 Authors: Urin V, Levin D, Sharma N, Harari D, Schreiber G Abstract Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for example in lupus, AIDS, tuberculosis and cognitive decline, highlighted the ... περισσότερα »

Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.* J Clin Neurosci. 2015 Jun;22(6):1005-11 Authors: Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY Abstract We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions. We identified a total of 70 patients (42 SJS, five SJS/TEN, 23 TEN). The female to ... περισσότερα »

Issue Information

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
from Physiology via xlomafota13 on Inoreader http://ift.tt/1Vg0dxq

Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task.* J Speech Lang Hear Res. 2016 Apr 18;:1-13 Authors: Guo LY, Schneider P Abstract Purpose: To determine the diagnostic accuracy of the finite verb morphology composite (FVMC), number of errors per C-unit (Errors/CU), and percent grammatical C-units (PGCUs) in differentiating school-aged children with language impairment (LI) and those with typical language development (TL). Method: Participants were 61 six-year-olds (50 TL, 11 LI) and 67 eight-ye...περισσότερα »

The Association Between Parental Mean Length of Utterance and Language Outcomes in Children With Disabilities: A Correlational Meta-Analysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*The Association Between Parental Mean Length of Utterance and Language Outcomes in Children With Disabilities: A Correlational Meta-Analysis.* Am J Speech Lang Pathol. 2016 Apr 18;:1-12 Authors: Sandbank M, Yoder P Abstract Purpose: The purpose of this correlational meta-analysis was to examine the association between parental utterance length and language outcomes in children with disabilities and whether this association varies according to other child characteristics, such as age and disability type. This association can serve as a starting point for language intervention pra... περισσότερα »

Between-language repetition priming in antonym generation: evidence that translation-equivalent adjectives have shared conceptual representations across languages.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Between-language repetition priming in antonym generation: evidence that translation-equivalent adjectives have shared conceptual representations across languages.* Memory. 2016 Apr 18;:1-6 Authors: Taylor RS, Francis WS Abstract Previous literature has demonstrated conceptual repetition priming across languages in bilinguals. This between-language priming effect is taken as evidence that translation equivalents have shared conceptual representations across languages. However, the vast majority of this research has been conducted using only concrete nouns as stimuli. The presen...περισσότερα »

Infant-Directed Speech Is Consistent With Teaching.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Infant-Directed Speech Is Consistent With Teaching.* Psychol Rev. 2016 Apr 18; Authors: Eaves BS, Feldman NH, Griffiths TL, Shafto P Abstract Infant-directed speech (IDS) has distinctive properties that differ from adult-directed speech (ADS). Why it has these properties-and whether they are intended to facilitate language learning-is a matter of contention. We argue that much of this disagreement stems from lack of a formal, guiding theory of how phonetic categories should best be taught to infantlike learners. In the absence of such a theory, researchers have relied on intuiti... περισσότερα »

Development and reliability of the Functional Communication Classification System for children with cerebral palsy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Development and reliability of the Functional Communication Classification System for children with cerebral palsy.* Dev Med Child Neurol. 2016 Apr 17; Authors: Barty E, Caynes K, Johnston LM Abstract AIM: This paper describes the development, validation, and reliability of the Functional Communication Classification System (FCCS), designed to classify expressive communication skills of children with cerebral palsy (CP) aged 4 years and 5 years (between their fourth and sixth birthdays). METHOD: The Functional Communication Classification System (FCCS) was developed in 2006 using...περισσότερα »

Neural Basis of Language: An Overview of An Evolving Model.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Neural Basis of Language: An Overview of An Evolving Model.* Neurol Med Chir (Tokyo). 2016 Apr 16; Authors: Fujii M, Maesawa S, Ishiai S, Iwami K, Futamura M, Saito K Abstract The neural basis of language had been considered as a simple model consisting of the Broca's area, the Wernicke's area, and the arcuate fasciculus (AF) connecting the above two cortical areas. However, it has grown to a larger and more complex model based upon recent advancements in neuroscience such as precise imaging studies of aphasic patients, diffusion tensor imaging studies, functional magnetic resona... περισσότερα »

Evidence Base Update for Autism Spectrum Disorder.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Related Articles *Evidence Base Update for Autism Spectrum Disorder.* J Clin Child Adolesc Psychol. 2015;44(6):897-922 Authors: Smith T, Iadarola S Abstract This evidence base update examines the level of empirical support for interventions for children with autism spectrum disorder (ASD) younger than 5 years old. It focuses on research published since a previous review in this journal (Rogers & Vismara, 2008 ). We identified psychological or behavioral interventions that had been manualized and evaluated in either (a) experimental or quasi-experimental group studies or (b) syste... περισσότερα »

Speech myoclonus due to probable pregabalin adverse drug-reaction.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Speech myoclonus due to probable pregabalin adverse drug-reaction.* Parkinsonism Relat Disord. 2015 Jul;21(7):823-4 Authors: Olszewska DA, Chalissery AJ, Williams J, Lynch T, Smyth S PMID: 25956204 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1clvtXB via IFTTT

The impact of cochlear implantation on cognition in older adults: a systematic review of clinical evidence.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The impact of cochlear implantation on cognition in older adults: a systematic review of clinical evidence.* BMC Geriatr. 2015;15:16 Authors: Miller G, Miller C, Marrone N, Howe C, Fain M, Jacob A Abstract BACKGROUND: Hearing loss is the third most prevalent chronic condition faced by older adults and has been linked to difficulties in speech perception, activities of daily living, and social interaction. Recent studies have suggested a correlation between severity of hearing loss and a... περισσότερα »

Competition between rhythmic and linguistic organization in a sentence-rhythm Stroop task.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Related Articles *Competition between rhythmic and linguistic organization in a sentence-rhythm Stroop task.* Q J Exp Psychol (Hove). 2015;68(11):2243-54 Authors: Getz LM, Salona P, Yu M, Kubovy M Abstract We provide a test of Patel's [( 2003 ). Language, music, syntax and the brain. Nature Neuroscience, 6, 674-681] shared syntactic integration resources hypothesis by investigating the competition between determinants of rhythmic parsing and linguistic parsing using a sentence-rhythm Stroop task. We played five-note rhythm patterns in which each note is replaced with a spoken wo...περισσότερα »

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
*Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.* J Biophotonics. 2016 Apr 18; Authors: Dias Schalch T, Porta Santos Fernandes K, Costa-Rodrigues J, Pereira Garcia M, Agnelli Mesquita-Ferrari R, Kalil Bussadori S, Fernandes MH Abstract The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (P...περισσότερα »

Toxic epidermal necrolysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Related Articles *Toxic epidermal necrolysis.* Anaesthesiol Intensive Ther. 2015;47(3):257-62 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, are rare, life- -threatening diseases that are characterised by extensive epidermal detachment, erosion of mucous membranes and severe systemic symptoms. In the majority of cases, the development of symptoms can be attributed to the use of drugs; therefore, the disease pathology is thought to be caused by a severe adve... περισσότερα »

The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Related Articles *The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.* Anaesthesiol Intensive Ther. 2015;47(3):210-3 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Głowacka M, Ożóg-Zabolska I Abstract BACKGROUND: Toxic epidermal necrosis (TEN) is a severe and life-threatening syndrome manifesting as extensive necrosis of the epidermis and mucous membranes accompanied by systemic symptoms. The causative factor is exposure to drugs, such as sulphonamides, antiepileptic preparations, non-steroidal anti-inflammatory drugs and paracetamol. The mechanism leadin...περισσότερα »

Drugs for the acute treatment of migraine in children and adolescents

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Drugs for the acute treatment of migraine in children and adolescents: Abstract Background Numerous medications are available for the acute treatment of migraine in adults, and some have now been approved for use in children and adolescents in the ambulatory setting. A systematic review of acute treatment of migraine medication trials in children and adolescents will help clinicians make evidence-informed management choices. Objectives To assess the effects of pharmacological interventions by any route of administration versus placebo for migraine in children and adolesce...περισσότερα »

The Journal of Headache and Pain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms an... Progressive muscle relaxation reduces migraine frequency and normalizes amplitudes of contingent negative variation (CNV) Central information processing, visible in evoked potentials like the contingent negative variation (CNV) is altered in migraine pati... περισσότερα »

Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study: Although alterations in resting-state neural network have been previously reported in migraine using functional MRI, whether this atypical neural network is frequency dependent remains unknown. The aim of this...

Progressive muscle relaxation reduces migraine frequency and normalizes amplitudes of contingent negative variation (CNV)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Progressive muscle relaxation reduces migraine frequency and normalizes amplitudes of contingent negative variation (CNV): Central information processing, visible in evoked potentials like the contingent negative variation (CNV) is altered in migraine patients who exhibit higher CNV amplitudes and a reduced habituation. Both chara...

Fine Tuning of a Type 1 Interferon Antagonist.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Fine Tuning of a Type 1 Interferon Antagonist.* PLoS One. 2015;10(7):e0130797 Authors: Urin V, Levin D, Sharma N, Harari D, Schreiber G Abstract Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for example in lupus, AIDS, tuberculosis and cognitive decline, highlighted the ... περισσότερα »

Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.* J Clin Neurosci. 2015 Jun;22(6):1005-11 Authors: Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY Abstract We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions. We identified a total of 70 patients (42 SJS, five SJS/TEN, 23 TEN). The female to ... περισσότερα »

Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
*Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.* J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Dursun F, Mohamoud HS, Karim N, Naeem M, Jelani M, Kırmızıbekmez H Abstract Perrault syndrome (PRLTS) is a heterogeneous group of clinical and genetic disorders in which patients are characterized by sensory neuronal hearing loss, in both sexes and premature ovarian failure or infertility in females. Neurological and hearing loss symptoms appear early in life; however, female infertility obviously cannot be detected before puberty. In...περισσότερα »

Swallowing Disorders in Severe Brain Injury in the Arousal Phase

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
Abstract The objective of this study was to determine the clinical characteristics of swallowing disorders in severe brain injury in the arousal phase after coma. Between December 1, 2013 and June 30, 2014, eleven patients with severe acquired brain injury who were admitted to rehabilitation center (Male 81.8 %; 40.7 ± 14.6 years) were included in the study. Evaluation of swallowing included a functional examination, clinical functional swallowing test, and naso-endoscopic swallowing test. All patients had swallowing disorders at admission. The first functional swallowing test sho... περισσότερα »

Prevalence and factors associated with oral potentially malignant disorders in Brazil′s rural workers

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: cover.gif?v=1&s=5b5fc3d9498c5386f9d6bb06] Abstract Objectives Determine the prevalence of Oral Potentially Malignant Disorders in a population of rural workers in the northeast of Brazil and investigate the association with socio-demographic, occupational and health factors. Methods 1385 workers answered a validated questionnaire and were examined by calibrated dentists. A descriptive analysis, chi-square homogeneity test and binary logistic regression were performed. Results The prevalence of OPMDs was 29.6%. Actinic cheilitis was the most predominant (28.4%), followe...περισσότερα »

Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.* Keio J Med. 2015;64(3):48-50 Authors: Sugiura Y, Nakagawa M, Hashizume T, Nemoto E, Kaseda S PMID: 26411779 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1qVSPuq via IFTTT

Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.* Am J Surg. 2016 Jan;211(1):250-67 Authors: Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ Abstract BACKGROUND: The effect of sleeve gastrectomy (SG) on the prevalence of gastroesophageal reflux disease (GERD) remains unclear. We aimed to outline the currently available literature. DATA SOURCES: All relevant databases were searched for publications examining the effect of laparoscopic SG on GERD. Primary outcome meas... περισσότερα »

A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
Related Articles *A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.* Gen Dent. 2015 Sep-Oct;63(5):e12-7 Authors: Metz MJ, Stapleton BM, Harris BT, Lin WS Abstract This case report describes preventive and restorative treatment planning for a 56-year-old female patient with severe, chronic, poorly controlled gastroesophageal reflux disease and resulting loss of vertical dimension of occlusion. First, the demineralization process was controlled through collaboration with the pa... περισσότερα »

[Congenital alacrima revealing a Allgrove syndrome: report of three cases].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Congenital alacrima revealing a Allgrove syndrome: report of three cases].* Pan Afr Med J. 2015;20:359 Authors: Derrar R, Boutimzine N, Laghmari A, Alouane A, Daoudi R PMID: 26185551 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/20TeC2k via IFTTT

[Why oesophageal adenocarcinoma is occurring more frequently].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
[image: http:--http://ift.tt/1PjZjdS] Related Articles *[Why oesophageal adenocarcinoma is occurring more frequently].* Ned Tijdschr Geneeskd. 2015;159:A8915 Authors: Doorakkers E, Brusselaers N Abstract The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk factors that might account for this rising incidence are reflux, obesity and the absence of Helicobacter pylori. Oesophageal adenocarcinoma is 9 times more likely in men than ... περισσότερα »

Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines: Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms an...

Acute idiopathic blue fingers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
a young man with Achenbach's syndrome: We report a case of a 20-year-old man presenting with acute painful blue fingers. All physical findings, including an Allen test, were normal, and systematic symptoms frequently seen in collagen diseases were absent. Although we performed a wide variety of investigations including medical imaging, no specific abnormal findings were observed. Skin biopsy pathology was an important reference. The patient's symptoms gradually improved and were completely resolved without specific treatment. Based on the clinical presentation and course, we gave a... περισσότερα »

Intratumoral expression of CCR3 in breast cancer is associated with improved relapse-free survival in luminal-like disease.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Intratumoral expression of CCR3 in breast cancer is associated with improved relapse-free survival in luminal-like disease.* Oncotarget. 2016 Apr 11; Authors: Gong DH, Fan L, Chen HY, Ding KF, Yu KD Abstract PURPOSE: The association chemokine receptor CCR3 with breast cancer subtypes and relapse-free survival is unknown. RESULTS: The overall expression (either intratumoral or peritumoral) of CCR3 was not associated with tumor size, lymph node status, age, and subtype. When we confined the analysis in samples without peritumoral stromal CCR3 expression, intratumo...περισσότερα »

Prediction of Malignancy in Bethesda Category III Nodules: Application of Thyroid Imaging Reporting System.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Prediction of Malignancy in Bethesda Category III Nodules: Application of Thyroid Imaging Reporting System.* Am Surg. 2015 Nov;81(11):E351-2 Authors: Şenol K, Katar K, Yüksel C, Saylam B, Tez M PMID: 26672561 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1SWUlTJ via IFTTT

Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
*Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region.* Nutr Res Pract. 2016 Apr;10(2):167-74 Authors: Ju DL, Park YJ, Paik HY, Kim MJ, Park S, Jung KY, Kim TH, Choi HS, Song YJ Abstract BACKGROUND/OBJECTIVES: Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and... περισσότερα »

Increased Risk of Atrial Fibrillation After Treatment for Differentiated Thyroid Carcinoma.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Increased Risk of Atrial Fibrillation After Treatment for Differentiated Thyroid Carcinoma.* J Clin Endocrinol Metab. 2015 Dec;100(12):4563-9 Authors: Hesselink EN, Lefrandt JD, Schuurmans EP, Burgerhof JG, Groen B, Gansevoort RT, van der Horst-Schrivers AN, Dullaart RP, Van Gelder IC, Brouwers AH, Rienstra M, Links TP Abstract BACKGROUND: Patients with differentiated thyroid carcinoma (DTC) have a favorable prognosis after treatment with thyroidectomy, radioiodine, and TSH suppression. However, treatment is associated with long-term cardiovascular toxicity. Th...περισσότερα »

BRAF testing and thyroid FNA.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *BRAF testing and thyroid FNA.* Cancer Cytopathol. 2015 Dec;123(12):689-95 Authors: Pusztaszeri MP, Krane JF, Faquin WC PMID: 26335367 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1U4veDi via IFTTT

Diffuse lipomatosis of the thyroid gland with papillary microcarcinoma: Report of a rare entity.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Diffuse lipomatosis of the thyroid gland with papillary microcarcinoma: Report of a rare entity.* Indian J Pathol Microbiol. 2015 Jul-Sep;58(3):348-50 Authors: Nandyala HS, Madapuram S, Yadav M, Katamala SK Abstract Presence of lobules of adipose tissue either focally or diffusely is very rare in the thyroid gland. Fat accumulation can be macroscopic or microscopic. Focal infiltrates of fat have been reported in conditions such as adenolipoma, intrathyroid lipoma, and encapsulated papillary carcinoma. Diffuse lipomatosis has been reported in conditions such as a... περισσότερα »

Primary cardiac sarcoma with metastases to thyroid and brain.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Primary cardiac sarcoma with metastases to thyroid and brain.* Indian J Pathol Microbiol. 2015 Jul-Sep;58(3):345-7 Authors: Yesodharan J, Kandamuthan S, Poothiode U Abstract Primary cardiac sarcomas are extremely rare with only a few large case series and isolated case reports in the literature. In spite of their aggressive nature with high chances of local recurrence and distant metastases, these tumors and their treatment strategies remain incompletely defined. We report an unsuspected case of primary cardiac pleomorphic undifferentiated sarcoma in a 52-year-o... περισσότερα »

Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.* Int J Clin Exp Pathol. 2015;8(5):5695-701 Authors: Kim HS, Lee JJ, Do SI, Kim K, Do IG, Kim DH, Chae SW, Sohn JH Abstract Cytokeratin 17 (CK17), a basal/myoepithelial cell keratin, appears to play an important role in the progression of several human malignancies. Increased CK17 expression has previously described in cases of papillary thyroid carcinoma (PTC). However, no studies to date have investigated the clinical sig... περισσότερα »

MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway.* Int J Clin Exp Pathol. 2015;8(5):5017-25 Authors: Wang X, Qiu W, Zhang G, Xu S, Gao Q, Yang Z Abstract MicroRNAs (miRNAs) have emerged as important regulators that potentially play critical roles in cancer cell biological processes. Previous studies have shown that miR-204 plays an important role in various human cancers. However, the underlying mechanisms of this microRNA in breast cancer remain largely unknown. In the present study, we investigated ... περισσότερα »

Characteristic location and growth patterns of functioning pituitary adenomas: correlation with histological distribution of hormone-secreting cells in the pituitary gland.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Characteristic location and growth patterns of functioning pituitary adenomas: correlation with histological distribution of hormone-secreting cells in the pituitary gland.* Clin Imaging. 2015 Sep-Oct;39(5):770-4 Authors: Baik JS, Lee MH, Ahn KJ, Choi HS, Jung SL, Kim BS, Jeun SS, Hong YK Abstract OBJECTIVE: To evaluate the correlation between the magnetic resonance imaging findings of functional pituitary adenomas and histological distribution of hormone-secreting cells in pituitary gland. METHODS: Forty-nine patients with pathologically confirmed functional mic... περισσότερα »

Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions.* PLoS One. 2015;10(5):e0126472 Authors: Dinets A, Pernemalm M, Kjellin H, Sviatoha V, Sofiadis A, Juhlin CC, Zedenius J, Larsson C, Lehtiö J, Höög A Abstract Cystic papillary thyroid carcinoma (cPTC) is a subgroup of PTC presenting a diagnostic challenge at fine needle aspiration biopsy (FNAB). To further investigate this entity we aimed to characterize protein profiles of cyst fluids from cPTC and benign thyroid cystic lesions. In total, 20 cPTCs ... περισσότερα »

Quiz answer page.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Quiz answer page.* Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):253, 267 Authors: Aravindan K PMID: 25885150 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1U4vaDA via IFTTT

Adenocarcinoma of the rete testis with prominent papillary structure and clear neoplastic cells: morphologic and immunohistochemical findings and differential diagnosis.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα
Related Articles *Adenocarcinoma of the rete testis with prominent papillary structure and clear neoplastic cells: morphologic and immunohistochemical findings and differential diagnosis.* Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):232-4 Authors: Huang PW, Chang KM Abstract Adenocarcinoma of the rete testis is rare, and its etiology is unknown. The definite diagnosis merely depends on the exclusion of other tumors and histological features. We first describe a 38-year-old man with a carcinoma arising in the rete testis. The tumor was characterized by clear neoplastic cells an... περισσότερα »

Monitoring sugar metabolism in liver may be a key to cancer diagnosis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Scientists may have discovered a significant new diagnostic marker for liver cancer, according to a paper published in Nature Cell Biology. A study led by The University of Texas MD Anderson Cancer Center found that a gene known as KHK (ketohexokinase or… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1reovMj via IFTTT

First computer program developed to detect DNA mutations in single cancer cells

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Researchers at The University of Texas MD Anderson Cancer Center have announced a new method for detecting DNA mutations in a single cancer cell versus current technology that analyses millions of cells which they believe could have important applications… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20TqNwe via IFTTT

Pharmaceuticals, Vol. 9, Pages 20: Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b. rhodesiense, Trypanosoma cruzi, Leishmania donovani and two Plasmodium falciparum subspecies: a chloroquine-sensitive strain (NF54) and a chloroquine-resistant strain (K1). The in vitro cytotoxicity was determined against rat myoblast cells (L6).… Continue reading Pharmaceuticals, Vol. 9, Pages 20: Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Newly discovered vulnerability in breast tumour cells points to new cancer treatment path

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. Now, a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found a way to attack a process that tumour cells use to escape the… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1reos2Z via IFTTT

A longitudinal study of neck and upper limb musculoskeletal disorders and alternative measures of vibration exposure

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Abstract Objective To investigate the exposure–response relationships between alternative frequency weightings of hand-transmitted vibration (HTV) and neck and upper limb musculoskeletal disorders (MSDs) in a cohort of HTV workers. Methods In a three-year longitudinal study, the occurrence of neck and upper limb MSDs was investigated in 249 HTV workers and 138 control men. In the… Continue reading A longitudinal study of neck and upper limb musculoskeletal disorders and alternative measures of vibration exposure

Technique could help identify patients who would suffer chemo-induced heart damage

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Cancer patients who receive a particular type of chemotherapy called doxorubicin run a risk of sustaining severe, lasting heart damage. But it is not possible to predict who is likely to experience this serious side effect. It is also unknown exactly… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20TqMZd via IFTTT

Precision prevention of colorectal cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Precision medicine’s public face is that of disease — and better treatments for that disease through targeted therapies. But precision medicine has an unsung partner that could affect the lives of many more people: Precision prevention — a reflection… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1reouba via IFTTT

Automated feature extraction for prospection and analysis of monumental earthworks from aerial LiDAR in the Kingdom of Tonga

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Publication date: May 2016 Source:Journal of Archaeological Science, Volume 69 Author(s): Travis Freeland, Brandon Heung, David V. Burley, Geoffrey Clark, Anders Knudby Recent LiDAR (Light Detection and Ranging) survey in Tonga has documented a dense and complex archaeological landscape, particularly on the principal island of Tongatapu. Among the features revealed by the LiDAR are a… Continue reading Automated feature extraction for prospection and analysis of monumental earthworks from aerial LiDAR in the Kingdom of Tonga

Grapevine carpological remains revealed the existence of a Neolithic domesticated Vitis vinifera L. specimen containing ancient DNA partially preserved in modern ecotypes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Publication date: May 2016 Source:Journal of Archaeological Science, Volume 69 Author(s): Angelo Gismondi, Gabriele Di Marco, Fabio Martini, Lucia Sarti, Manna Crespan, Cristina Martínez-Labarga, Olga Rickards, Antonella Canini Thirty-four carpological remains, found in the Neolithic layers of Grotta della Serratura (Southern Italy), were subjected to morphological analysis in order to identify their botanical origin. The… Continue reading Grapevine carpological remains revealed the existence of a Neolithic domesticated Vitis vinifera L. specimen containing ancient DNA partially pres... περισσότερα »

AACR 2016: Three years and counting on atezolizumab for stage 4 CRC patient

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Bearfoot, who was diagnosed with Stage IV colorectral cancer in 2008, shows stable disease after three years and counting on atezolizumab from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20TqMbz via IFTTT

Posterior fossa anatomy through novel radiology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Posterior fossa anatomy through novel radiology.* Clin Anat. 2016 Apr 18; Authors: Siegel J, Lundy L, Dove C, Mansour P, Wszolek Z PMID: 27087543 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WCUMrX

Approaches of targeting Rho GTPases in cancer drug discovery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Approaches of targeting Rho GTPases in cancer drug discovery.* Expert Opin Drug Discov. 2015;10(9):991-1010 Authors: Lin Y, Zheng Y Abstract INTRODUCTION: Rho GTPases are master regulators of actomyosin structure and dynamics and play pivotal roles in a variety of cellular processes including cell morphology, gene transcription, cell cycle progression, and cell adhesion. Because aberrant Rho GTPase signaling activities are widely associated with human cancer, key components of Rho GTPase signaling pathways have attracted incr... περισσότερα »

Drug discovery in prostate cancer mouse models.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Drug discovery in prostate cancer mouse models.* Expert Opin Drug Discov. 2015;10(9):1011-24 Authors: Valkenburg KC, Pienta KJ Abstract INTRODUCTION: The mouse is an important, though imperfect, organism with which to model human disease and to discover and test novel drugs in a preclinical setting. Many experimental strategies have been used to discover new biological and molecular targets in the mouse, with the hopes of translating these discoveries into novel drugs to treat prostate cancer in humans. Modeling prostate canc... περισσότερα »

The discovery and development of omalizumab for the treatment of asthma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *The discovery and development of omalizumab for the treatment of asthma.* Expert Opin Drug Discov. 2015;10(9):1033-42 Authors: Licari A, Marseglia G, Castagnoli R, Marseglia A, Ciprandi G Abstract INTRODUCTION: The evolution in immunological methods used to assess human allergic diseases has led to the identification of immunoglobulin E (IgE) as a diagnostic biomarker and a potential therapeutic target. Innovative technologies in molecular biology and immunogenetics contributed to the development of a selective blocking agent,... περισσότερα »

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.* J Biophotonics. 2016 Apr 18; Authors: Dias Schalch T, Porta Santos Fernandes K, Costa-Rodrigues J, Pereira Garcia M, Agnelli Mesquita-Ferrari R, Kalil Bussadori S, Fernandes MH Abstract The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (P...περισσότερα »

Toxic epidermal necrolysis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *Toxic epidermal necrolysis.* Anaesthesiol Intensive Ther. 2015;47(3):257-62 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, are rare, life- -threatening diseases that are characterised by extensive epidermal detachment, erosion of mucous membranes and severe systemic symptoms. In the majority of cases, the development of symptoms can be attributed to the use of drugs; therefore, the disease pathology is thought to be caused by a severe adver... περισσότερα »

The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.* Anaesthesiol Intensive Ther. 2015;47(3):210-3 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Głowacka M, Ożóg-Zabolska I Abstract BACKGROUND: Toxic epidermal necrosis (TEN) is a severe and life-threatening syndrome manifesting as extensive necrosis of the epidermis and mucous membranes accompanied by systemic symptoms. The causative factor is exposure to drugs, such as sulphonamides, antiepileptic preparations, non-steroidal anti-inflammatory drugs and paracetamol. The mechanism leading... περισσότερα »

Fine Tuning of a Type 1 Interferon Antagonist.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Fine Tuning of a Type 1 Interferon Antagonist.* PLoS One. 2015;10(7):e0130797 Authors: Urin V, Levin D, Sharma N, Harari D, Schreiber G Abstract Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for example in lupus, AIDS, tuberculosis and cognitive decline, highlighted the n... περισσότερα »

Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.* J Clin Neurosci. 2015 Jun;22(6):1005-11 Authors: Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY Abstract We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions. We identified a total of 70 patients (42 SJS, five SJS/TEN, 23 TEN). The female to m... περισσότερα »

Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth cell adhesion and filamentation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation.* Appl Microbiol Biotechnol. 2016 Apr 18; Authors: Matsubara VH, Wang Y, Bandara HM, Mayer MP, Samaranayake LP Abstract We evaluated the inhibitory effects of the probiotic Lactobacillus species on different phases of Candida albicans biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on C. albicans biofilms treated with Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus acidophil... περισσότερα »

Medical service use in children with cerebral palsy: The role of child and family factors characteristics.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Medical service use in children with cerebral palsy: The role of child and family factors characteristics.* J Paediatr Child Health. 2016 Apr 18; Authors: Meehan EM, Reid SM, Williams KJ, Freed GL, Sewell JR, Reddihough DS Abstract AIM: The aim of the study was to investigate the patterns of medical service use in children with cerebral palsy (CP), taking into account child and family characteristics. METHODS: Nine hundred and one parents and carers of children registered with the Victorian CP Register were invited to complete a survey. Participants were asked about their child's... περισσότερα »

A missed scalp laceration causing avoidable sequelae.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*A missed scalp laceration causing avoidable sequelae.* Int J Surg Case Rep. 2016 Apr 11;23:61-64 Authors: Basyuni S, Panayi A, Sharma V, Santhanam V Abstract INTRODUCTION: We present the case of an overlooked scalp laceration in an 81-year-old lady who presented with polytrauma following a fall down stairs. Complications that developed required more extensive treatment compared to what would have sufficed with early identification. PRESENTATION OF CASE: Imaging on admission to hospital showed multiple vertebrae and rib fractures as well as a large cranial subcutaneous haematoma w...περισσότερα »

A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report.* Int J Surg Case Rep. 2016 Apr 11;23:56-60 Authors: Niemann KE, Kröpil F, Hoffmann MF, Coulibaly MO, Schildhauer TA Abstract INTRODUCTION: Tumoral calcinosis (TC) is a rare disorder defined by hyperphosphatemia and ectopic calcifications in various locations. The most common form of TC is associated with disorders such as renal insufficiency, hyperparathyroidism, or hypervitaminosis D. The primary (hereditary) TC is caused by inactivating mutations in either the fi...περισσότερα »

Retraction notice to: Gallstone ileus without bilioenteric fistula years after bypass surgery for Crohn's disease. Case report and clues to etiology of a neglected cause of obstruction [IJSCR Volume 9 2015 Pages 134-138].

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Retraction notice to: Gallstone ileus without bilioenteric fistula years after bypass surgery for Crohn's disease. Case report and clues to etiology of a neglected cause of obstruction [IJSCR Volume 9, 2015, Pages 134-138].* Int J Surg Case Rep. 2016;21:157 Authors: Pellino G, Candilio G, De Fatico GS, Marcellinaro R, Formicola GC, Volpicelli A, Sciaudone G, Riegler G, Canonico S, Selvaggi F Abstract This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://ift.tt/1poHqya). The report has been retracted at the request of the authors. Following noti... περισσότερα »

Less noise more activation: Multiband acquisition schemes for auditory functional MRI.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Less noise, more activation: Multiband acquisition schemes for auditory functional MRI.* Magn Reson Med. 2015 Aug;74(2):462-7 Authors: De Martino F, Moerel M, Ugurbil K, Formisano E, Yacoub E Abstract PURPOSE: To improve acquisition in fMRI studies of audition by using multiband (MB) gradient-echo echo planar imaging (GE-EPI). METHODS: Data were acquired at 3T (Siemens Skyra) with a 32-channel head coil. Functional responses were obtained by presenting stimuli [tones and natural sounds (voices, speech, music, tools... περισσότερα »

Effect of Photobiomodulation on Transforming Growth Factor-β1 Platelet-Derived Growth Factor-BB and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Effect of Photobiomodulation on Transforming Growth Factor-β1, Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study.* Photomed Laser Surg. 2016 Apr 18; Authors: Keskiner I, Lutfioğlu M, Aydogdu A, Saygun NI, Serdar MA Abstract OBJECTIVE: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF)-BB, and i... περισσότερα »

Effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts.* Diagn Interv Radiol. 2016 Apr 18; Authors: Özgen A Abstract PURPOSE: We aimed to evaluate the effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts. METHODS: From January 2002 to January 2014, 35 simple breast cysts (mean volume, 8.2 mL; range, 4-33 mL) in 28 females (mean age, 39 years) were evaluated. In a single session, all cysts were aspirated using 20G needles, refilled with 99% ethanol (90% of the volume of the ...περισσότερα »

Is there a role for microsampling in antibiotic pharmacokinetic studies?

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Is there a role for microsampling in antibiotic pharmacokinetic studies?* Expert Opin Drug Metab Toxicol. 2016 Apr 18; Authors: Parker SL, Dorofaeff T, Lipman J, Ballot DE, Bandini RM, Wallis SC, Roberts JA Abstract INTRODUCTION: Clinical pharmacokinetic studies of antibiotics can establish evidence-based dosing regimens that improve the likelihood of eradicating the pathogen at the site of infection, reduce the potential for selection of resistant pathogens, and minimize harm to the patient. Innovations in small volume sampling (< 50 μL) or 'microsampling' may result in less-in...περισσότερα »

Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.* Histol Histopathol. 2016 Apr 18;:11768 Authors: Zheng Z, Yu S, Zhang W, Peng Y, Pu M, Kang T, Zeng J, Yu Y, Li G Abstract INTRODUCTION: Phytoestrogen genistein may be useful to treat pulmonary arterial hypertension (PAH). However, its mechanism is still not clear. The aim of the present study was to confirm the therapeutic effects of phytoestrogen genistein on PAH in monocrotaline-induced rat model and to explore its mechanism. MATERIALS AND METHODS: Sprague-... περισσότερα »

macrophage; 33 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/04/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SWUTZT

Imidazo[1,2-a]pyridines: promising drug candidate for antitumor therapy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Imidazo[1,2-a]pyridines: promising drug candidate for antitumor therapy.* Curr Top Med Chem. 2016 Apr 14; Authors: Goel R, Luxami V, Paul K Abstract Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[1,2-a]pyridine based analogues have been used as lead mol... περισσότερα »

Phospholipid-Based Prodrugs for Drug Targeting in Inflammatory Bowel Disease: Computational Optimization and in-Vitro Correlation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Phospholipid-Based Prodrugs for Drug Targeting in Inflammatory Bowel Disease: Computational Optimization and in-Vitro Correlation.* Curr Top Med Chem. 2016 Apr 14; Authors: Dahan A, Ben-Shabat S, Cohen N, Keinan S, Kurnikov I, Aponick A, Zimmermann EM Abstract In inflammatory bowel disease (IBD) patients, the enzyme phospholipase A2 (PLA2) is overexpressed in the inflamed intestinal tissue, and hence may be exploited as a prodrug-activating enzyme allowing drug targeting to the site(s) of gut inflammation. The purpose of this work was to develop powerful modern computational app...περισσότερα »

Therapeutic Potentials of Triterpenes in Diabetes and its Associated Complications.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Therapeutic Potentials of Triterpenes in Diabetes and its Associated Complications.* Curr Top Med Chem. 2016 Apr 14; Authors: Putta S, Yarla NS, Kilari EK, Surekha C, Aliev G, Divakara MB, Santosh MS, Ramu R, Zameer F, Nagendra Prasad MN, Chintala R, Rao PV, Shiralgi Y, Dhananjaya BL Abstract Diabetes is a major chronic metabolic disorder globally and around of 285 million people are affected by the disease and the number is expected to double in the next two decades. The major focus of anti-diabetic therapies is to enhance insulin production, sensitivity and/or reduce the blood...περισσότερα »

Important Aspects of Post-Prandial Antidiabetic Drug, Acarbose.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Important Aspects of Post-Prandial Antidiabetic Drug, Acarbose.* Curr Top Med Chem. 2016 Apr 14; Authors: Singla RK, Singh R, Dubey AK Abstract Acarbose, a well known and efficacious α-amylase and α-glucosidase inhibitor, is a post-prandial acting antidiabetic drug. DNS-based α-amylase inhibitory assays showed that use of acarbose at concentrations above 125 µg/ml resulted in release of reducing sugar in the reaction, an unexpected observation. Objective of the present study was to design experimental strategies to address this unusual finding. Acarbose was found to be susceptib...περισσότερα »

Recent Advancement in Natural Hyaluronidase Inhibitors.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Recent Advancement in Natural Hyaluronidase Inhibitors.* Curr Top Med Chem. 2016 Apr 14; Authors: Scotti L, Singla RK, Ishiki HM, Mendonça Júnior FJ, da Silva MS, Filho JM, Scotti MT Abstract The use of natural products for the treatment of disease is one of the oldest cultures that exists. Currently, the research of new drugs using natural products shows a poorly explored biodiversity and a great interest of marketing. The enzymatic inhibition by some natural products investigated among these is the inhibition of hyaluronidase and the consequent reduction of the degradation of ... περισσότερα »

Obesity: the metabolic disease, advances on drug discovery and natural product research.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Obesity: the metabolic disease, advances on drug discovery and natural product research.* Curr Top Med Chem. 2016 Apr 15; Authors: Castro M, Preto M, Vasconcelos V, Urbatzka R Abstract Obesity is a global health threat. OECD reported that more than half (52%) of the adult population in the European Union is overweight or obese. Obesity and obesity-related co-morbidities have deep negative effects on morbidity, mortality, professional and personal quality of life. Health-care costs represent a negative impact of this disease, with an associated economic cost of 100 billion US$ pe... περισσότερα »

Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases.* Curr Top Med Chem. 2016 Apr 14; Authors: Nie L, Song H, He A, Yao S Abstract Lipid metabolic disorder refers to the dyslipidemia in the plasma. Abnormal working or lipid metabolism process leads to supernormal increase of one or multi kinds of lipids in plasma. It is a significant risk factor for many diseases and has become a serious danger to the mankind health. The clinical drugs adjusting lipid levels have a great variety in the market, side effects and adverse reactions. Meanwhile,... περισσότερα »

Histone variants and composition in the developing brain: should MeCP2 care?

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Histone variants and composition in the developing brain: should MeCP2 care?* Curr Top Med Chem. 2016 Apr 14; Authors: Zago V, Pinar-CabezaDeVaca C, Vincent JB, Ausió J Abstract Specific compositional chromatin features distinguish brain/neuronal chromatin from that of other tissues and are critical to this organ and cell type development and neuroplasticity. These features include a significant turnover of the major constitutive chromosomal proteins, including the (canonical) replication-dependent histones, the replication-independent replacement histone variants, as well as th...περισσότερα »

Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation.* Curr Top Med Chem. 2016 Apr 14; Authors: Cacci E, Negri R, Biagioni S, Lupo G Abstract Neural stem/progenitor cell (NSPC) self-renewal and differentiation in the developing and the adult brain are controlled by extra-cellular signals and by the inherent competence of NSPCs to produce appropriate responses. Stage-dependent responsiveness of NSPCs to extrinsic cues is orchestrated at the epigenetic level. Epigenetic mechanisms such as DNA methylatio... περισσότερα »

Epigenetic Basis of Neuronal and Synaptic Plasticity.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Epigenetic Basis of Neuronal and Synaptic Plasticity.* Curr Top Med Chem. 2016 Apr 14; Authors: Karpova NN, Sales AJ, Joca SR Abstract Neuronal network and plasticity change as a function of experience. Altered neural connectivity leads to distinct transcriptional programs of neuronal plasticity-related genes. The environmental challenges throughout life may promote long-lasting reprogramming of gene expression and the development of brain disorders. The modifications in neuronal epigenome mediate gene-environmental interactions and are required for activity-dependent regulation...περισσότερα »

Overview of the Genetic Basis and Epigenetic Mechanisms that Contribute to FASD Pathobiology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Overview of the Genetic Basis and Epigenetic Mechanisms that Contribute to FASD Pathobiology.* Curr Top Med Chem. 2016 Apr 14; Authors: Liyanage VR, Curtis K, Zachariah RM, Chudley AE, Rastegar M Abstract Prenatal alcohol (ethanol) exposure (PAE) is the underlying cause for a variety of birth defects and neurodevelopmental deficits referred to as "Fetal Alcohol Spectrum Disorders (FASD)". The more visible phenotypes caused by PAE include growth retardation, and characteristic craniofacial abnormalities associated with functional and structural damage to the central nervous syste...περισσότερα »

Identifying at Diagnosis the Vestibular Schwannomas at Low Risk of Growth in a Long-term Retrospective Cohort.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Identifying at Diagnosis the Vestibular Schwannomas at Low Risk of Growth in a Long-term Retrospective Cohort.* Clin Otolaryngol. 2016 Apr 18; Authors: Wolbers JG, Dallenga AH, van Linge A, Te West M, Kummer EE, Méndez Romero A, Pauw BK, Wieringa MH Abstract OBJECTIVES: Identification at time of diagnosis of those vestibular schwannomas that will not grow. DESIGN: Retrospective cohort study of consecutive patients diagnosed with a sporadic vestibular schwannoma that were entered in the wait-and-scan protocol. SETTING: Academic referral centre. PARTICIPANTS: The study group contai... περισσότερα »

STEADFAST: Psychotherapeutic Intervention Improves Postural Strategy of Somatoform Vertigo and Dizziness.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *STEADFAST: Psychotherapeutic Intervention Improves Postural Strategy of Somatoform Vertigo and Dizziness.* Behav Neurol. 2015;2015:456850 Authors: Best C, Tschan R, Stieber N, Beutel ME, Eckhardt-Henn A, Dieterich M Abstract Patients with somatoform vertigo and dizziness (SVD) disorders often report instability of stance or gait and fear of falling. Posturographic measurements indeed indicated a pathological postural strategy. Our goal was to evaluate the effectiveness of a ... περισσότερα »

Anti-Ri-associated paraneoplastic brainstem cerebellar syndrome with coexisting limbic encephalitis in a patient with mixed large cell neuroendocrine lung carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Anti-Ri-associated paraneoplastic brainstem cerebellar syndrome with coexisting limbic encephalitis in a patient with mixed large cell neuroendocrine lung carcinoma.* J Clin Neurosci. 2015 Feb;22(2):421-3 Authors: Mitchell AN, Bakhos CT, Zimmerman EA Abstract Paraneoplastic neurologic syndromes (PNS) can be the first manifestations of occult malignancies. If left untreated, PNS often lead to significant morbidity and mortality. Anti-Ri (anti-neuronal nuclear antibody type 2 [ANNA-2]) autoantibodies are commonly a... περισσότερα »

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism.* Nat Immunol. 2016 Apr 18; Authors: Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA, Moore KJ Abstract Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. We found that by inducing the microRNA (miRNA) miR-33 an... περισσότερα »

Coordinated induction of cell survival signaling in the inflamed microenvironment of the prostate.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Coordinated induction of cell survival signaling in the inflamed microenvironment of the prostate.* Prostate. 2016 Jun;76(8):722-734 Authors: McIlwain DW, Zoetemelk M, Myers JD, Edwards MT, Snider BM, Jerde TJ Abstract PURPOSE: Both prostate cancer and benign prostatic hyperplasia are associated with inflammatory microenvironments. Inflammation is damaging to tissues, but it is unclear how the inflammatory microenvironment protects specialized epithelial cells that function to proliferate and repair the tissue. The objective of this study is to characterize the cell death and ce...περισσότερα »

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.* ACS Infect Dis. 2016 Apr 8;2(4):268-280 Authors: Koselny K, Green J, Favazzo L, Glazier VE, DiDone L, Ransford S, Krysan DJ Abstract AR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear. Based on a chemical-genetic prof...περισσότερα »

Fine-tuning of macrophage activation using synthetic rocaglate derivatives.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
*Fine-tuning of macrophage activation using synthetic rocaglate derivatives.* Sci Rep. 2016;6:24409 Authors: Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I Abstract Drug-resistant bacteria represent a significant global threat. Given the dearth of new antibiotics, host-directed therapies (HDTs) are especially desirable. As IFN-gamma (IFNγ) plays a central role in host resistance to intracellular bacteria, including Mycobacterium tuberculosis, we searched for small molecules to augment the IFNγ response in macrophages. Using an interferon-induci... περισσότερα »

Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring.* Euro Surveill. 2015;20(45) Authors: Little K, Leang SK, Butler J, Baas C, Harrower B, Mosse J, Barr IG, Hurt AC Abstract Surveillance of circulating influenza strains for antiviral susceptibility is important to ensure patient treatment guidelines remain appropriate. Influenza A(H3N2) and A(H1N1)pdm09 virus isolates containing mutations at the Q136 residue of the neuraminidase ... περισσότερα »

Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons.* Euro Surveill. 2015;20(46) Authors: Bonmarin I, Belchior E, Bergounioux J, Brun-Buisson C, Mégarbane B, Chappert JL, Hubert B, Le Strat Y, Lévy-Bruhl D Abstract During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire usin...περισσότερα »

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus.* MBio. 2015;6(4):e01044 Authors: Schwartzman LM, Cathcart AL, Pujanauski LM, Qi L, Kash JC, Taubenberger JK Abstract UNLABELLED: Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine ea... περισσότερα »

Reply to Decker et al.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *Reply to Decker et al.* Clin Infect Dis. 2015 Oct 15;61(8):1345 Authors: Linkin DR, Richardson DM PMID: 26157051 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SpFUdw via IFTTT

Regarding Primary Care Patients Who Received Influenza Vaccine at Veteran Health Administration Medical Centers.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
Related Articles *Regarding Primary Care Patients Who Received Influenza Vaccine at Veteran Health Administration Medical Centers.* Clin Infect Dis. 2015 Oct 15;61(8):1344-5 Authors: Decker MD, DiazGranados CA, Chit A, Hosbach P, Robertson CA, Greenberg DP PMID: 26157048 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SpFUdo via IFTTT

Attitudes and perceptions among the pediatric health care providers toward influenza vaccination in Qatar: A cross-sectional study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Attitudes and perceptions among the pediatric health care providers toward influenza vaccination in Qatar: A cross-sectional study.* Vaccine. 2015 Jul 31;33(32):3821-8 Authors: Alhammadi A, Khalifa M, Abdulrahman H, Almuslemani E, Alhothi A, Janahi M Abstract BACKGROUND: Influenza is a communicable but preventable viral illness. Despite safe and effective vaccine availability, compliance rates are globally low. Neither local data on percentage of vaccination nor reasons for poor compliance among pediatric health ... περισσότερα »

Reasons for low influenza vaccination coverage among adults in Puerto Rico, influenza season 2013-2014.

Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Reasons for low influenza vaccination coverage among adults in Puerto Rico, influenza season 2013-2014.* Vaccine. 2015 Jul 31;33(32):3829-35 Authors: Arriola CS, Mercado-Crespo MC, Rivera B, Serrano-Rodriguez R, Macklin N, Rivera A, Graitcer S, Lacen M, Bridges CB, Kennedy ED Abstract BACKGROUND: Influenza vaccination is recommended annually for all persons 6 months and older. Reports of increased influenza-related morbidity and mortality during the 2013-2014 influenza season raised concerns about low adult influ... περισσότερα »

Dyspnoea, cough, mild haemoptysis, chest pain and night sweats

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
A diagnostic dilemma in a case of pulmonary inflammatory myofibroblastic tumour: An 18-year-old man presented to the local hospital in Malta, with dyspnoea, cough, mild haemoptysis, chest pain and night sweats. CT revealed a right hilar mass. Pleural tap, bronchoscopy and open lung biopsy were inconclusive. Biopsies obtained at repeat bronchoscopy and endobronchial ultrasound (EBUS) revealed a likely diagnosis of inflammatory myofibroblastic tumour (IMT). The patient subsequently underwent right pneumonectomy, and histology revealed the presence of two further nodules apart from t...περισσότερα »

Single-staged vs. two-staged implant placement in vertically deficient alveolar ridges using bone ring technique - Part 2: implant osseointegration

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 15 δευτερόλεπτα
Abstract Objectives The aim of this study was to evaluate the osseointegration of implants placed in a single-staged compared to two-staged procedure using bone ring technique. Material and Methods In this study were used standardized, vertical alveolar bone defects in dogs. In the test group, dental implants (Straumann BL®, Basel, Switzerland) were inserted simultaneously with bone ring technique. As control group served implants inserted 6 months following grafting. Implants of both groups were left for an osseointegration period of 3 and 6 months. The peri-implant bone loss and ... περισσότερα »

Prevalence and factors associated with oral potentially malignant disorders in Brazils rural workers

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 15 δευτερόλεπτα
[image: cover.gif?v=1&s=5b5fc3d9498c5386f9d6bb06] Abstract Objectives Determine the prevalence of Oral Potentially Malignant Disorders in a population of rural workers in the northeast of Brazil and investigate the association with socio-demographic, occupational and health factors. Methods 1385 workers answered a validated questionnaire and were examined by calibrated dentists. A descriptive analysis, chi-square homogeneity test and binary logistic regression were performed. Results The prevalence of OPMDs was 29.6%. Actinic cheilitis was the most predominant (28.4%), followed by... περισσότερα »

Aggressive polyposis and malignancies in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
A mild phenotype associated with a de novo microdeletion 10q23.1-q23.2: a new patient with a novel feature: Chromosome 10q23 contains several genes, including *PTEN* and *BMPR1A*, the mutations or microdeletion of which are associated with aggressive polyposis and malignancies in children. Deletions in this chromosomal region have also been associated with heart anomalies, developmental delay and macrocephaly. Most of the cases reported involve the *PTEN* and *BMPR1A* genes, usually associated with complex and severe anomalies. We report a case of a boy with a de novo interstitial ... περισσότερα »

Migratory pushpin in the tracheobronchial tree

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Migratory pushpin in the tracheobronchial tree: Description A healthy 10-year-old boy presented to the emergency department, with a 3-day history of cough and odynophagia, which started after eating squid. On examination, he had decreased breath sounds in the lower half of the right lung. The physical examination was otherwise unremarkable. Chest X-ray showed a consolidation of the right lower lobe with small pleural effusion, and a foreign body in the right bronchus (figure 1A). The patient was admitted for antibiotic treatment and bronchoscopy, but had a sudden onset of coughing w...περισσότερα »

Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
*Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.* J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Dursun F, Mohamoud HS, Karim N, Naeem M, Jelani M, Kırmızıbekmez H Abstract Perrault syndrome (PRLTS) is a heterogeneous group of clinical and genetic disorders in which patients are characterized by sensory neuronal hearing loss, in both sexes and premature ovarian failure or infertility in females. Neurological and hearing loss symptoms appear early in life; however, female infertility obviously cannot be detected before puberty. In...περισσότερα »

Complication of thyroid surgery : Lymphoedema of the upper limb

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Lymphoedema of the upper limb: a rare complication of thyroid surgery?: A 40-year-old woman underwent an elective thyroidectomy for a non-toxic, multinodular goitre. In the early postoperative period, the patient developed a significant unilateral swelling of the right upper limb, which was subsequently confirmed to be lymphoedema. This was eventually treated successfully using liposuction and compression garment therapies. We report the case due to its rarity and present a possible explanation for such an unexpected complication based on known anatomical variations of lymphatic dr...περισσότερα »

Dentigerous cyst arising from a complex odontoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
an unusual presentation: Description A 21-year-old man presented with pain in the right posterior region of the jaw for 10–15 days. The pain was mild, dull and non-radiating in nature, beginning with slight pressure and relieved within seconds. Clinically, the patient was healthy with an unremarkable medical history. On inspection, the patient had congenitally missing mandibular molar teeth along with absence of clinical swelling intraorally. Panoramic radiograph showed an amorphous, dense, irregularly shaped radio-opacity surrounded by a well-defined radiolucency in the apical reg...περισσότερα »

Thyroid storm. Clinical manifestations of thyroid storm include unexplained weight loss, hyperactivity and irritability. The most common causes of thyrotoxicosis are Graves' disease, toxic multinodular goitre and toxic adenoma. We present a rare case of thyroid storm induced by dual nivolumab and ipilimumab immunotherapy in a patient receiving treatment for advanced melanoma.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
A rare case of Thyroid storm is a rare and life-threatening state of thyroid hormone excess. Rapid recognition of thyroid storm is key to decreasing the morbidity and mortality of this condition. Clinical manifestations of thyroid storm include unexplained weight loss, hyperactivity and irritability. The most common causes of thyrotoxicosis are Graves' disease, toxic multinodular goitre and toxic adenoma. We present a rare case of thyroid storm induced by dual nivolumab and ipilimumab immunotherapy in a patient receiving treatment for advanced melanoma. In this case, our patient... περισσότερα »

Extensive upper respiratory tract sarcoidosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Extensive upper respiratory tract sarcoidosis: Sarcoidosis is a chronic granulomatous disease of unknown aetiology. It can affect any part of the organism, although the lung is the most frequently affected organ. Upper airway involvement is rare, particularly if isolated. Sarcoidosis is a diagnosis of exclusion, established by histological evidence of non-caseating granulomas and the absence of other granulomatous diseases. The authors report a case of a man with sarcoidosis manifesting as a chronic inflammatory stenotic condition of the upper respiratory tract and trachea.

Reticulated, Hyperchromic Rash in a Striated Pattern Mimicking Atopic Dermatitis and Fungal Infection in a 2-Month-Old Female: A Case of Incontinentia Pigmenti

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 δευτερόλεπτα
We present a 12-month-old Hispanic female with a reticulated, hyperchromic rash in a striated pattern appearing on upper and lower extremities and trunk and back since the age of 6 weeks. Over the next 10 months, the rash persisted. The rash did not respond to treatment with antifungals and steroids. During her 6-month wellness visit, the patient was diagnosed with incontinentia pigmenti (IP), a rare X-linked dominant disorder, fatal to male fetuses in utero. IP can lead to serious neurological and ophthalmologic consequences. Early diagnosis by primary care physicians and parenta... περισσότερα »

Azathioprine-induced bullous Sweet's syndrome : High-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
a rare association: A 52-year-old man presented with high-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo. There was neither any history of preceding respiratory or gastrointestinal tract infection, nor was the patient known to have malignancy, drug hypersensitivity, inflammatory bowel disease, vasculitis or other autoimmune disease. Laboratory results revealed leucocytosis with neutrophilia and markedly elevated... περισσότερα »

Dry Eye Disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Two Patients with Dry Eye Disease Followed Up Using an Expression Assay of Ocular Surface Mucin: *Purpose:* We report 2 patients with dry eye disease followed up using the expression levels of ocular surface mucin. *Case Reports:* Patient 1: a 57-year-old woman with Sjögren's syndrome-associated dry eyes experienced severe dryness and foreign body sensation in both her eyes, and instilled sodium hyaluronate ophthalmic solution 0.3% about 10-15 times daily. We measured the expression levels of MUC5AC mRNA *(MUC5AC)* and MUC16 mRNA *(MUC16)* by using real-time reversed transcription p... περισσότερα »

Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 19 δευτερόλεπτα
*Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 in a Turkish family.* J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Dursun F, Mohamoud HS, Karim N, Naeem M, Jelani M, Kırmızıbekmez H Abstract Perrault syndrome (PRLTS) is a heterogeneous group of clinical and genetic disorders in which patients are characterized by sensory neuronal hearing loss, in both sexes and premature ovarian failure or infertility in females. Neurological and hearing loss symptoms appear early in life; however, female infertility obviously cannot be detected before puberty. In...περισσότερα »

Reticulated, Hyperchromic Rash in a Striated Pattern Mimicking Atopic Dermatitis and Fungal Infection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
in a 2-Month-Old Female: A Case of Incontinentia Pigmenti: We present a 12-month-old Hispanic female with a reticulated, hyperchromic rash in a striated pattern appearing on upper and lower extremities and trunk and back since the age of 6 weeks. Over the next 10 months, the rash persisted. The rash did not respond to treatment with antifungals and steroids. During her 6-month wellness visit, the patient was diagnosed with incontinentia pigmenti (IP), a rare X-linked dominant disorder, fatal to male fetuses in utero. IP can lead to serious neurological and ophthalmologic consequence... περισσότερα »

Economic impact of patients admitted to stroke units in Spain

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
The European Journal of Health Economics from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSThU

Short-term outcomes for medicare beneficiaries after low-acuity visits to emergency departments and clinics

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Medical Care from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDIAk

A prospective comparative study between color doppler ultrasound with twinkling and non-contrast computed tomography in the evaluation of acute renal colic

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
The Journal of Urology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSRGR

Space-2: a missed opportunity to compare carotid endarterectomy carotid stenting and best medical treatment in patients with asymptomatic carotid stenoses

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
European Journal of Vascular and Endovascular Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFVd

Risk factors associated with outbreak of methanol poisoning in southern districts of Ondo State Nigeria May 2015

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
International Journal of Infectious Diseases from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSThM

Effect of remote ischemic preconditioning on postoperative acute kidney injury among patients undergoing cardiac and vascular interventions: A meta-analysis

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Journal of Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFV6

Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Pediatric Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSThH

Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Cardiovascular Diabetology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFV2

Evaluation of needle stick injuries among health care workers in a teaching hospital

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
International Journal of Infectious Diseases from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSQm7

Targeting iron homeostasis in acute kidney injury

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Seminars in Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDIjK

Identification and management of neonatal skull fractures

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Journal of Perinatology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSRqg

Mending a broken heart but breaking the kidney

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDIjC

Is access to and use of patient perceived patient-centered medical homes associated with reduced nonurgent emergency department use?

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
American Journal of Medical Quality from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSQ5C

Occupational injuries among building construction workers in Addis Ababa Ethiopia

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Journal of Occupational Medicine and Toxicology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFEs

Treatment with PMX-DHP and CHDF in premature neonates with systemic inflammatory response syndrome

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Pediatrics International from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSPPe

Atypical onset of bicalutamide-induced liver injury

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
World Journal of Gastroenterology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFo2

Modified pectoralis major myocutaneous flap for the total glossectomy defects

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Effect on quality of life: Background There is a general notion that, total glossectomy with laryngeal preservation leads to high dependency of tracheostomy and/or feeding tube. The objective of this study is to analyze the quality of life in terms of tube dependency following total glossectomy with a modified pectoralis major myocutaneous flap (PMMC) reconstruction and laryngeal suspension. Materials and Methods The retrospective study included consecutive patients operated from July 2012 to February 2015 proven advanced Carcinoma of tongue. We analyzed the time to wean off trache... περισσότερα »

Multiphoton tomography and fluorescence lifetime imaging of human brain tumor tissue

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
In vivo AbstractHigh resolution multiphoton tomography and fluorescence lifetime imaging differentiates glioma from adjacent brain in native tissue samples ex vivo. Presently, multiphoton tomography is applied in clinical dermatology and experimentally. We here present the first application of multiphoton and fluorescence lifetime imaging for in vivo imaging on humans during a neurosurgical procedure. We used a MPTflex™ Multiphoton Laser Tomograph (JenLab, Germany). We examined cultured glioma cells in an orthotopic mouse tumor model and native human tissue samples. Finally the mu...περισσότερα »

Acute encephalitis with abnormal liver function tests: question and answer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Acute encephalitis with abnormal liver function tests: question and answer.* J Clin Neurosci. 2016 Jan;23:128, 169 Authors: Merwick A, Cowley P, Ingle G PMID: 27088142 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SWYwio via IFTTT

Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line.* Artif Cells Nanomed Biotechnol. 2016 Apr 17;:1-11 Authors: Akbal Ö, Erdal E, Vural T, Kavaz D, Denkbaş EB Abstract In this study, human serum albumin (HSA) was used as a protein-based material and poly (3-hydroxybutyrate) (PHB)-carboxymethyl chitosan (CMCh) as a polysaccharide-based material for the production of nanoparticles to be used as nanocarriers in cancer therapy. HSA and PHB-CMCh nanoparticles were ...περισσότερα »

Posterior fossa anatomy through novel radiology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Posterior fossa anatomy through novel radiology.* Clin Anat. 2016 Apr 18; Authors: Siegel J, Lundy L, Dove C, Mansour P, Wszolek Z PMID: 27087543 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WCUMrX via IFTTT

Approaches of targeting Rho GTPases in cancer drug discovery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Approaches of targeting Rho GTPases in cancer drug discovery.* Expert Opin Drug Discov. 2015;10(9):991-1010 Authors: Lin Y, Zheng Y Abstract INTRODUCTION: Rho GTPases are master regulators of actomyosin structure and dynamics and play pivotal roles in a variety of cellular processes including cell morphology, gene transcription, cell cycle progression, and cell adhesion. Because aberrant Rho GTPase signaling activities are widely associated with human cancer, key components of Rho GTPase signaling pathways have attracted inc... περισσότερα »

Drug discovery in prostate cancer mouse models.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Drug discovery in prostate cancer mouse models.* Expert Opin Drug Discov. 2015;10(9):1011-24 Authors: Valkenburg KC, Pienta KJ Abstract INTRODUCTION: The mouse is an important, though imperfect, organism with which to model human disease and to discover and test novel drugs in a preclinical setting. Many experimental strategies have been used to discover new biological and molecular targets in the mouse, with the hopes of translating these discoveries into novel drugs to treat prostate cancer in humans. Modeling prostate can... περισσότερα »

The discovery and development of omalizumab for the treatment of asthma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *The discovery and development of omalizumab for the treatment of asthma.* Expert Opin Drug Discov. 2015;10(9):1033-42 Authors: Licari A, Marseglia G, Castagnoli R, Marseglia A, Ciprandi G Abstract INTRODUCTION: The evolution in immunological methods used to assess human allergic diseases has led to the identification of immunoglobulin E (IgE) as a diagnostic biomarker and a potential therapeutic target. Innovative technologies in molecular biology and immunogenetics contributed to the development of a selective blocking agent... περισσότερα »

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.* J Biophotonics. 2016 Apr 18; Authors: Dias Schalch T, Porta Santos Fernandes K, Costa-Rodrigues J, Pereira Garcia M, Agnelli Mesquita-Ferrari R, Kalil Bussadori S, Fernandes MH Abstract The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (P...περισσότερα »

Toxic epidermal necrolysis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
Related Articles *Toxic epidermal necrolysis.* Anaesthesiol Intensive Ther. 2015;47(3):257-62 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, are rare, life- -threatening diseases that are characterised by extensive epidermal detachment, erosion of mucous membranes and severe systemic symptoms. In the majority of cases, the development of symptoms can be attributed to the use of drugs; therefore, the disease pathology is thought to be caused by a severe adve... περισσότερα »

The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
Related Articles *The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.* Anaesthesiol Intensive Ther. 2015;47(3):210-3 Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Głowacka M, Ożóg-Zabolska I Abstract BACKGROUND: Toxic epidermal necrosis (TEN) is a severe and life-threatening syndrome manifesting as extensive necrosis of the epidermis and mucous membranes accompanied by systemic symptoms. The causative factor is exposure to drugs, such as sulphonamides, antiepileptic preparations, non-steroidal anti-inflammatory drugs and paracetamol. The mechanism leadin...περισσότερα »

Fine Tuning of a Type 1 Interferon Antagonist.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Fine Tuning of a Type 1 Interferon Antagonist.* PLoS One. 2015;10(7):e0130797 Authors: Urin V, Levin D, Sharma N, Harari D, Schreiber G Abstract Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for example in lupus, AIDS, tuberculosis and cognitive decline, highlighted the ... περισσότερα »

Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.* J Clin Neurosci. 2015 Jun;22(6):1005-11 Authors: Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY Abstract We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions. We identified a total of 70 patients (42 SJS, five SJS/TEN, 23 TEN). The female to ... περισσότερα »

Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation.* Appl Microbiol Biotechnol. 2016 Apr 18; Authors: Matsubara VH, Wang Y, Bandara HM, Mayer MP, Samaranayake LP Abstract We evaluated the inhibitory effects of the probiotic Lactobacillus species on different phases of Candida albicans biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on C. albicans biofilms treated with Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus acidophil... περισσότερα »

Medical service use in children with cerebral palsy: The role of child and family factors characteristics.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Medical service use in children with cerebral palsy: The role of child and family factors characteristics.* J Paediatr Child Health. 2016 Apr 18; Authors: Meehan EM, Reid SM, Williams KJ, Freed GL, Sewell JR, Reddihough DS Abstract AIM: The aim of the study was to investigate the patterns of medical service use in children with cerebral palsy (CP), taking into account child and family characteristics. METHODS: Nine hundred and one parents and carers of children registered with the Victorian CP Register were invited to complete a survey. Participants were asked about their child's... περισσότερα »

A missed scalp laceration causing avoidable sequelae.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*A missed scalp laceration causing avoidable sequelae.* Int J Surg Case Rep. 2016 Apr 11;23:61-64 Authors: Basyuni S, Panayi A, Sharma V, Santhanam V Abstract INTRODUCTION: We present the case of an overlooked scalp laceration in an 81-year-old lady who presented with polytrauma following a fall down stairs. Complications that developed required more extensive treatment compared to what would have sufficed with early identification. PRESENTATION OF CASE: Imaging on admission to hospital showed multiple vertebrae and rib fractures as well as a large cranial subcutaneous haematoma w...περισσότερα »

A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report.* Int J Surg Case Rep. 2016 Apr 11;23:56-60 Authors: Niemann KE, Kröpil F, Hoffmann MF, Coulibaly MO, Schildhauer TA Abstract INTRODUCTION: Tumoral calcinosis (TC) is a rare disorder defined by hyperphosphatemia and ectopic calcifications in various locations. The most common form of TC is associated with disorders such as renal insufficiency, hyperparathyroidism, or hypervitaminosis D. The primary (hereditary) TC is caused by inactivating mutations in either the fi...περισσότερα »

Retraction notice to: Gallstone ileus without bilioenteric fistula years after bypass surgery for Crohn's disease. Case report and clues to etiology of a neglected cause of obstruction [IJSCR Volume 9, 2015, Pages 134-138].

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Retraction notice to: Gallstone ileus without bilioenteric fistula years after bypass surgery for Crohn's disease. Case report and clues to etiology of a neglected cause of obstruction [IJSCR Volume 9, 2015, Pages 134-138].* Int J Surg Case Rep. 2016;21:157 Authors: Pellino G, Candilio G, De Fatico GS, Marcellinaro R, Formicola GC, Volpicelli A, Sciaudone G, Riegler G, Canonico S, Selvaggi F Abstract This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://ift.tt/1poHqya). The report has been retracted at the request of the authors. Following noti... περισσότερα »

Less noise, more activation: Multiband acquisition schemes for auditory functional MRI.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Less noise, more activation: Multiband acquisition schemes for auditory functional MRI.* Magn Reson Med. 2015 Aug;74(2):462-7 Authors: De Martino F, Moerel M, Ugurbil K, Formisano E, Yacoub E Abstract PURPOSE: To improve acquisition in fMRI studies of audition by using multiband (MB) gradient-echo echo planar imaging (GE-EPI). METHODS: Data were acquired at 3T (Siemens Skyra) with a 32-channel head coil. Functional responses were obtained by presenting stimuli [tones and natural sounds (voices, speech, music, tool... περισσότερα »

The Brief Cognitive Status Exam (BCSE),the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Cognitive screening in patients with intracranial tumors: validation of the BCSE: AbstractThis study presents the first validation of the Brief Cognitive Status Exam (BCSE) against two other screening tools for cognitive impairment in patients with intracranial tumors. 58 patients and 22 matched healthy controls completed the BCSE, the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Patients were additionally tested with a comprehensive neuropsychological battery. Based on this assessment, they were classified as cognitively impaired or unimpaire... περισσότερα »

Cognitive screening in patients with intracranial tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
validation of the BCSE: AbstractThis study presents the first validation of the Brief Cognitive Status Exam (BCSE) against two other screening tools for cognitive impairment in patients with intracranial tumors. 58 patients and 22 matched healthy controls completed the BCSE, the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Patients were additionally tested with a comprehensive neuropsychological battery. Based on this assessment, they were classified as cognitively impaired or unimpaired on five cognitive domains. Analyses revealed a comparabl...περισσότερα »

B7-H4 facilitates proliferation of esophageal squamous cell carcinoma cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
through promoting IL-6/STAT3 pathway activation: [image: cover.gif?v=1&s=8b3f6943b778324eb0968d22] Summary B7-H4, one of the costimulatory molecules of B7 family, has been found to be widely expressed in many kinds of tumor tissues and to play an important part in tumor progression and poor prognosis. However, the role of B7-H4 in esophageal squamous cell carcinoma (ESCC) cells has not been elucidated. In this study, we found that, compared with normal esophageal tissue, B7-H4 was highly expressed in three ESCC cell lines, Eca109, TE1 and TE13. Besides, B7-H4 silence suppressed... περισσότερα »

Stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non–small cell lung cancer: BACKGROUND The optimal treatment for patients with brain metastases remains controversial as the use of stereotactic radiosurgery (SRS) alone, replacing whole-brain radiation therapy (WBRT), has increased. This study determined the patterns of care at multiple institutions before 2010 and examined whether or not survival was different between patients treated with SRS and patients treated with WBRT. METHODS This st... περισσότερα »

Spine radiosurgery treatment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Variability in spine radiosurgery treatment planning – results of an international multi-institutional study: Abstract BackgroundThe aim of this study was to quantify the variability in spinal radiosurgery (SRS) planning practices between five international institutions, all member of the Elekta Spine Radiosurgery Research Consortium. MethodsFour institutions provided one representative patient case each consisting of the medical history, CT and MR imaging. A step-wise planning approach was used where, after each planning step a consensus was generated that formed the basis for... περισσότερα »

Fractionated stereotactic radiotherapy of benign skull-base tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
a dosimetric comparison of volumetric modulated arc therapy with Rapidarc® versus non-coplanar dynamic arcs: Abstract Background Benign tumors of the skull base are a challenge when delivering radiotherapy. An appropriate choice of radiation technique may significantly improve the patient’s outcomes. Our study aimed to compare the dosimetric results of fractionated stereotactic radiotherapy between non-coplanar dynamic arcs and coplanar volumetric modulated arctherapy (Rapidarc®). Methods Thirteen patients treated with Novalis TX® were analysed: six vestibular schwannoma... περισσότερα »

C-reactive protein as a prognostic factor in patients with chordoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
of lumbar spine and sacrum—a single center pilot study: Abstract Study designThis is a retrospective, diagnostic study, level IV. BackgroundIt appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival? MethodsSurvival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20–85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; ran... περισσότερα »

De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
pathogenesis revisited: Abstract BackgroundThe pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma. Case presentationWe are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to bot...περισσότερα »

Targeting iron homeostasis in acute kidney injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Seminars in Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDIjK via IFTTT

Identification and management of neonatal skull fractures

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Journal of Perinatology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSRqg via IFTTT

Mending a broken heart but breaking the kidney

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDIjC via IFTTT

Is access to and use of patient perceived patient-centered medical homes associated with reduced nonurgent emergency department use?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
American Journal of Medical Quality from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSQ5C via IFTTT

Occupational injuries among building construction workers in Addis Ababa Ethiopia

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Journal of Occupational Medicine and Toxicology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFEs via IFTTT

Treatment with PMX-DHP and CHDF in premature neonates with systemic inflammatory response syndrome

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Pediatrics International from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SrSPPe via IFTTT

Atypical onset of bicalutamide-induced liver injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
World Journal of Gastroenterology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1YEDFo2 via IFTTT

Economic impact of patients admitted to stroke units in Spain

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
The European Journal of Health Economics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SrSThU via IFTTT

Short-term outcomes for medicare beneficiaries after low-acuity visits to emergency departments and clinics

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Medical Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1YEDIAk via IFTTT

A prospective comparative study between color doppler ultrasound with twinkling and non-contrast computed tomography in the evaluation of acute renal colic

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
The Journal of Urology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SrSRGR via IFTTT

Space-2: a missed opportunity to compare carotid endarterectomy, carotid stenting, and best medical treatment in patients with asymptomatic carotid stenoses

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
European Journal of Vascular and Endovascular Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1YEDFVd via IFTTT

Risk factors associated with outbreak of methanol poisoning in southern districts of Ondo State Nigeria, May 2015

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
International Journal of Infectious Diseases from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SrSThM via IFTTT

Effect of remote ischemic preconditioning on postoperative acute kidney injury among patients undergoing cardiac and vascular interventions: A meta-analysis

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Journal of Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1YEDFV6 via IFTTT

Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Pediatric Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SrSThH via IFTTT

Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Cardiovascular Diabetology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1YEDFV2 via IFTTT

Evaluation of needle stick injuries among health care workers in a teaching hospital

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
International Journal of Infectious Diseases from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SrSQm7 via IFTTT

Targeting iron homeostasis in acute kidney injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Seminars in Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1YEDIjK via IFTTT

Phase Ib Trial of mFOLFOX6 and Everolimus (NSC-733504) in Patients with Metastatic Gastroesophageal Adenocarcinoma

Objectives: Based upon preclinical data showing synergy with mTOR inhibition and platinum chemotherapy, this study explores the safety and tolerability of combining everolimus with mFOLFOX6 for patients with metastatic gastroesophageal adenocarcinoma. Methods: Eligible patients with metastatic gastroesophageal adenocarcinoma received standard-dose mFOLFOX6 chemotherapy in combination with escalating doses of everolimus. Results: Six patients were accrued to […]

The effect of desflurane on postoperative olfactory memory

OBJECTIVE: In this study, we investigated the effects of desflurane 6%, on olfactory memory. PATIENTS AND METHODS: This is a prospective clinical study performed with 40 patients aged 18-60 who had elective surgery and American Society of Anesthesiologists (ASA) physical status I-III. The Brief Smell Identification Test (BSIT) was used for evaluating patients’ olfactory memories […]

Cell Adhesion on Polycaprolactone Modified by Plasma Treatment

We have investigated the influence of various plasma treatments of electrospun polycaprolactone (PCL) scaffolds on the adhesion and proliferation of human umbilical endothelial cells (HUVEC). The PCL scaffolds were treated in plasmas created in O2, NH3 or SO2 gas at identical conditions. Surface functionalization of plasma-treated samples was determined using X-ray photoelectron spectroscopy. Cell adhesion […]

Ki-67 system in histological grading of soft tissue sarcomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Prospective evaluation of Ki-67 system in histological grading of soft tissue sarcomas in the Japan Clinical Oncology Group Study JCOG0304: Abstract BackgroundThe correct clinical staging of soft tissue sarcomas (STS) is critical for the selection of treatments. The staging system consists of histological grade of the tumors and French Federation of Cancer Center (FNCLCC) system based on mitotic count is widely used for the grading. In this study, we compared the validity and usefulness of Ki-67 grading system with FNCLCC system in JCOG0304 trial which investigated the efficacy and...περισσότερα »

Intervertebral disc herniation with intradural schwannoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Coexistence of intervertebral disc herniation with intradural schwannoma in a lumbar segment: a case report: Abstract BackgroundLumbar intervertebral disc herniation and spinal tumor are major pathologies that may cause back pain and radiculopathy. Neurological symptoms resulting from disc herniation and intradural spinal tumor together, however, are very rare. Case presentationWe report a case of lumbar disc herniation which coexists with intradural schwannoma at the same spinal level in a 67-year-old man. The patient presented with persistent low back pain, sciatica, and weakn... περισσότερα »

Merkel cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
demographic, clinical, and treatment parameters of prognostic significance: Abstract ObjectivesWe aimed to define the impact of patient, tumor, surgical, and radiotherapy (RT) treatment parameters on Merkel cell carcinoma (MCC) recurrence and survival. MethodsThe study was a retrospective review of 45 patients with primary disease evaluated between 1981 and 2012 at a single U.S. institution and treated with curative intent. ResultsThe American Joint Committee on Cancer (AJCC) stage was I in 42.2 %, II in 8.9 %, III in 26.7 %, and unknown in 22.2 %. 95.6 % underwent primary ... περισσότερα »

Prenatal brain MRI of fetuses with Zika virus infection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Prenatal brain MRI of fetuses with Zika virus infection: Abstract BackgroundAn outbreak of Zika virus was observed in French Polynesia in 2013–2014. Maternal Zika virus infection has been associated with fetal microcephaly and severe cerebral damage. ObjectiveTo analyze the MRI cerebral findings in fetuses with intrauterine Zika virus infection. Materials and methodsWe retrospectively analyzed prospectively collected data. Inclusion criteria comprised cases with (1) estimated conception date between June 2013 and May 2014, (2) available US and MRI scans revealing severe fet... περισσότερα »

Proton Therapy : CNS Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury via International Journal of Radiation Oncology*Biology*Physics [image: 1-s2.0-S0360301616X00041-cov150h.gif] Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Drosoula Giantsoudi, Roshan V. Sethi, Beow Y. Yeap, Bree R. Eaton, David H. Ebb, Paul A. Caruso, Otto Rapalino, Yen-Lin E. Chen, Judith A. Adams, Torunn I. Yock, Nancy J. Tarbell, Harald Paganetti, Shannon...περισσότερα »

Proton Therapy in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers via International Journal of Radiation Oncology*Biology*Physics [image: 1-s2.0-S0360301616X00041-cov150h.gif] Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Roos Leroy, Nadia Benahmed, Frank Hulstaert, Nancy Van Damme, Dirk De Ruysscher Because it spares many normal tissues and reduces the integral dose, proton therapy (PT) is the preferred tumor irradiation technique for treating childhood cancer. However, to the best of our knowled... περισσότερα »

Proton System Used for Craniospinal Irradiation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Measured Neutron Spectra and Dose Equivalents From a Mevion Single-Room, Passively Scattered Proton System Used for Craniospinal Irradiation via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Rebecca M. Howell, Eric A. Burgett, Daniel Isaacs, Samantha G. Price Hedrick, Michael P. Reilly, Leith J. Rankine, Kevin K. Grantham, Stephanie Perkins, Eric E. Klein PurposeTo measure, in the setting of typical passively scattered proton craniospinal irradi... περισσότερα »

Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model via International Journal of Radiation Oncology*Biology*Physics [image: 1-s2.0-S0360301616X00041-cov150h.gif] Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Stefanie Girst, Christoph Greubel, Judith Reindl, Christian Siebenwirth, Olga Zlobinskaya, Dietrich W.M. Walsh, Katarina Ilicic, Michaela Aichler, Axel Walch, Jan J. Wilkens, Gabriele Multhoff, Günther Dollinger, Thomas E. Schmid PurposeProton minibeam radiation the... περισσότερα »

Composite Fillings

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 37 δευτερόλεπτα
The post Composite Fillings appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1XGkx98 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Proton Therapy for Chordomas and Chondrosarcomas of the Spine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
A Prospective Outcomes Study of via International Journal of Radiation Oncology*Biology*Physics [image: 1-s2.0-S0360301616X00041-cov150h.gif] Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Daniel J. Indelicato, Ronny L. Rotondo, Dustin Begosh-Mayne, Mark T. Scarborough, C. Parker Gibbs, Christopher G. Morris, William M. Mendenhall PurposeTo evaluate the effectiveness of definitive or adjuvant external beam proton therapy on survival in patients with chordomas and chondrosarcomas of the spine.Methods an... περισσότερα »

Proton Beam Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Editorial 1. - - Particle Therapy at the “Tipping Point”: An Introduction to the Red Journal's Special Edition - *Pages 1-3* - Anthony L. Zietman - - Purchase PDF - $35.95 - Not entitled to full text Politics, Philosophy, and Economics Commentary 2. - - Impediments to Comparative Clinical Trials With Proton Therapy - *Pages 4-8* - James D. Cox - - Purchase PDF - $35.95 - Not entitled to full text 3. - - Reconciling Reimbursement for Proton Therapy ... περισσότερα »

Adjuvant Proton Therapy Combined With Surgery for Chondrosarcoma of the Skull Base

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Efficacy and Safety of : A Retrospective, Population-Based Study via International Journal of Radiation Oncology*Biology*Physics [image: 1-s2.0-S0360301616X00041-cov150h.gif] Publication date: 1 May 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 95, Issue 1 Author(s): Loïc Feuvret, Stefano Bracci, Valentin Calugaru, Stéphanie Bolle, Hamid Mammar, Ludovic De Marzi, Damien Bresson, Jean-Louis Habrand, Jean-Jacques Mazeron, Rémi Dendale, Georges Noël PurposeChondrosarcoma is a rare malignant tumor of the cartilage affecting young adults. Surgery, follow... περισσότερα »

Natural killer cell immunotherapy to target stem-like tumor cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Natural killer cell immunotherapy to target stem-like tumor cells: AbstractAdvances in cancer immunotherapy are leading to its increasing and successful application for the treatment of solid–tissue cancers. Despite the recent advances there are still significant barriers, in particular, evidence for significant tumor heterogeneity, both genetic and epigenetic that limit long-term efficacy. Subpopulations of “stem-like” tumor cells have been identified in nearly all human malignancies based on both morphologic and functional criteria. Also called cancer stem cells or CSCs, these qu... περισσότερα »

Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer: Abstract BackgroundThe currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphatic injections, limiting their feasibility. Here, we report on the feasibility and safety of a new method of long-term repetitive intralymphatic (IL) infusion of immune cells, using implantable delivery ports. MethodsNine patients with... περισσότερα »

"Does the voice in your head get kinder as you get older?" Women's perceptions of body image in midlife.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 45 δευτερόλεπτα
*"Does the voice in your head get kinder as you get older?" Women's perceptions of body image in midlife.* J Women Aging. 2016 Apr 18;:1-8 Authors: Rodgers RF, Paxton SJ, McLean SA, Damiano SR Abstract This study aimed to identify attitudes and reactions toward physical changes in midlife women. A Facebook thread, presenting a series of comments related to an initial statement, instigated by a radio program was analyzed. The thread contained 87 responses to the question "Does the voice in your head get kinder as you get older?" Content analysis revealed positive (56%) and negativ...περισσότερα »

A novel null mutation in P450 aromatase gene (CYP19A1) associated with the development of hypoplastic ovaries in humans.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 45 δευτερόλεπτα
*A novel null mutation in P450 aromatase gene (CYP19A1) associated with the development of hypoplastic ovaries in humans.* J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Lee SJ, Akçurin S, Türkkahraman D, Kim WY, Durmaz E, Shin JG Abstract OBJECTIVE: The CYP19A1 gene product aromatase is responsible for estrogen synthesis and androgen/estrogen equilibrium in many tissues, particularly in the placenta and gonads. Aromatase deficiency can cause various clinical phenotypes resulting from excessive androgen accumulation and insufficient estrogen synthesis during the pre- and pos... περισσότερα »

"Does the voice in your head get kinder as you get older?" Women's perceptions of body image in midlife.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 45 δευτερόλεπτα
*"Does the voice in your head get kinder as you get older?" Women's perceptions of body image in midlife.* J Women Aging. 2016 Apr 18;:1-8 Authors: Rodgers RF, Paxton SJ, McLean SA, Damiano SR Abstract This study aimed to identify attitudes and reactions toward physical changes in midlife women. A Facebook thread, presenting a series of comments related to an initial statement, instigated by a radio program was analyzed. The thread contained 87 responses to the question "Does the voice in your head get kinder as you get older?" Content analysis revealed positive (56%) and negativ...περισσότερα »

A novel null mutation in P450 aromatase gene (CYP19A1) associated with the development of hypoplastic ovaries in humans.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 45 δευτερόλεπτα
*A novel null mutation in P450 aromatase gene (CYP19A1) associated with the development of hypoplastic ovaries in humans.* J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Lee SJ, Akçurin S, Türkkahraman D, Kim WY, Durmaz E, Shin JG Abstract OBJECTIVE: The CYP19A1 gene product aromatase is responsible for estrogen synthesis and androgen/estrogen equilibrium in many tissues, particularly in the placenta and gonads. Aromatase deficiency can cause various clinical phenotypes resulting from excessive androgen accumulation and insufficient estrogen synthesis during the pre- and pos... περισσότερα »

Targetless T cells in cancer immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Targetless T cells in cancer immunotherapy: AbstractAttention has recently focused on new cancer immunotherapy protocols aiming to activate T cell mediated anti-tumor responses. To this end, administration of antibodies that target inhibitory molecules regulating T-cell cytotoxicity has achieved impressive clinical responses, as has adoptive cell transfer (ACT) using expanded tumor infiltrating lymphocytes (TIL) or genetically modified cytotoxic T cells. However, despite clear clinical responses, only a fraction of patients respond to treatment and there is an urgent call for chara... περισσότερα »

Characterize subtypes of HPV-positive head and neck cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Characterize subtypes of HPV-positive head and neck cancers: Purpose:There is substantial heterogeneity within human papillomavirus (HPV) associated head and neck cancer (HNC) tumors that predispose them to different outcomes, however the molecular heterogeneity in this subgroup is poorly characterized due to various historical reasons. Experimental Design:We performed unsupervised gene expression clustering on deeply-annotated (transcriptome and genome) HPV(+) HNC samples from two cohorts (84 total primary tumors), including 18 HPV(-) HNC samples, to discover subtypes and characte... περισσότερα »

Docetaxel plus lobaplatin for patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
An open-label, single-arm phase II clinical study of To evaluate the efficacy and safety of the chemotherapy program of docetaxel combined with lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma (NPC). This study included 37 NPC patients with pulmonary and hepatic metastasis. The chemotherapy program included docetaxel (75 mg/m2, day 1) plus lobaplatin (30 mg/m2, day 1). Cycle repetition was every 21 days. Patients were monitored for 7-41 months, with a median follow-up duration of 18 months. The total efficiency of this group was 67...περισσότερα »

Phase Ib Trial of mFOLFOX6 and Everolimus (NSC-733504) in Patients with Metastatic Gastroesophageal Adenocarcinoma

Objectives: Based upon preclinical data showing synergy with mTOR inhibition and platinum chemotherapy, this study explores the safety and tolerability of combining everolimus with mFOLFOX6 for patients with metastatic gastroesophageal adenocarcinoma. Methods: Eligible patients with metastatic gastroesophageal adenocarcinoma received standard-dose mFOLFOX6 chemotherapy in combination with escalating doses of everolimus. Results: Six patients were accrued to […]

The effect of desflurane on postoperative olfactory memory

OBJECTIVE: In this study, we investigated the effects of desflurane 6%, on olfactory memory. PATIENTS AND METHODS: This is a prospective clinical study performed with 40 patients aged 18-60 who had elective surgery and American Society of Anesthesiologists (ASA) physical status I-III. The Brief Smell Identification Test (BSIT) was used for evaluating patients’ olfactory memories […]

IJERPH, Vol. 13, Pages 432: Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Mainstream psychological stress theory claims that it is important to include information on people’s ways of coping with work stress when assessing the impact of stressful psychosocial work environments on health. Yet, some widely used respective theoretical models focus exclusively on extrinsic factors. The model of effort-reward imbalance (ERI) differs from them as it explicitly […]

IJERPH, Vol. 13, Pages 430: Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses

The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. […]

IJERPH, Vol. 13, Pages 433: Up-Regulation of Long Non-Coding RNA AB073614 Predicts a Poor Prognosis in Patients with Glioma

Dysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially in cancer. Emerging evidence indicates that dysregulated lncRNAs are implicated in tumorigenesis and cancer progression. LncRNA AB073614 characterized as a new candidate lncRNA promotes the development of ovarian cancer. However, the role of lncRNA AB073614 in human gliomas remains unknown. The expression of […]

Exposure To Asbestos – TheSequitur.com

Exposure To Asbestos TheSequitur.com This disease has been found to exist in other organs of the body as well such as the larynx, pancreas and colon, but those instances are extremely limited compared to lung cancer incidents. The chance of developing mesothelioma is in direct proportion … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SWRES5 via […]

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from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Vg0dxq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Tumore del rene: «Il 25% dei casi diagnosticato in stadio avanzato» – Meteo Web

Meteo Web Tumore del rene: «Il 25% dei casi diagnosticato in stadio avanzato» Meteo Web Il melanoma ha aperto la strada, a seguire il tumore del polmone non a piccole cellule (nelle due istologie, squamoso e non squamoso), e, negli ultimi mesi, il carcinoma renale e i tumori del distretto testa collo. Questo approccio innovativo […]

Die Bedeutung der kraniellen Bestrahlung als Bestandteil moderner Therapieprotokolle für das Überleben bei Kindern mit akuter lymphoblastischer Leukämie

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1rcJIpI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Effect of intratympanic steroid administration on sensorineural hearing loss associated with acute otitis media.

Effect of intratympanic steroid administration on sensorineural hearing loss associated with acute otitis media. J Laryngol Otol. 2016 Apr 18;:1-4 Authors: Heywood RL, Ifeacho SN, Narula AA Abstract OBJECTIVE: To evaluate a small cohort of patients who presented with symptoms and signs consistent with acute infective sensorineural hearing loss who were treated with intratympanic steroids. […]

Immune Checkpoint Blockade with anti-PD-1 Antibody Therapy : Autoimmune Dermatologic Toxicities

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
A Report on Bullous Skin Eruptions: Abstract Monoclonal antibodies against the immune checkpoint programmed cell death receptor 1 (PD-1) improve the hosts’ antitumor immune response and have demonstrated tremendous promise in the treatment of advanced solid tumors and hematologic malignancies. Reports of serious autoimmune dermatologic toxicities from immune checkpoint blockade therapy, however, are emerging. We report our experience with five patients who presented with pruritic vesicles and blisters on the skin while treated with anti-PD-1 antibody immunotherapy with either nivol... περισσότερα »

Effect of Photobiomodulation on Transforming Growth Factor-β1, Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Effect of Photobiomodulation on Transforming Growth Factor-β1, Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study.* Photomed Laser Surg. 2016 Apr 18; Authors: Keskiner I, Lutfioğlu M, Aydogdu A, Saygun NI, Serdar MA Abstract OBJECTIVE: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF)-BB, and i... περισσότερα »

Effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts.* Diagn Interv Radiol. 2016 Apr 18; Authors: Özgen A Abstract PURPOSE: We aimed to evaluate the effectiveness of single-session ultrasound-guided percutaneous ethanol sclerotherapy in simple breast cysts. METHODS: From January 2002 to January 2014, 35 simple breast cysts (mean volume, 8.2 mL; range, 4-33 mL) in 28 females (mean age, 39 years) were evaluated. In a single session, all cysts were aspirated using 20G needles, refilled with 99% ethanol (90% of the volume of the ...περισσότερα »

Is there a role for microsampling in antibiotic pharmacokinetic studies?

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Is there a role for microsampling in antibiotic pharmacokinetic studies?* Expert Opin Drug Metab Toxicol. 2016 Apr 18; Authors: Parker SL, Dorofaeff T, Lipman J, Ballot DE, Bandini RM, Wallis SC, Roberts JA Abstract INTRODUCTION: Clinical pharmacokinetic studies of antibiotics can establish evidence-based dosing regimens that improve the likelihood of eradicating the pathogen at the site of infection, reduce the potential for selection of resistant pathogens, and minimize harm to the patient. Innovations in small volume sampling (< 50 μL) or 'microsampling' may result in less-in...περισσότερα »

Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.* Histol Histopathol. 2016 Apr 18;:11768 Authors: Zheng Z, Yu S, Zhang W, Peng Y, Pu M, Kang T, Zeng J, Yu Y, Li G Abstract INTRODUCTION: Phytoestrogen genistein may be useful to treat pulmonary arterial hypertension (PAH). However, its mechanism is still not clear. The aim of the present study was to confirm the therapeutic effects of phytoestrogen genistein on PAH in monocrotaline-induced rat model and to explore its mechanism. MATERIALS AND METHODS: Sprague-... περισσότερα »

macrophage; +33 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/04/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SWUTZT via IFTTT

Screening first-degree relatives for gastric cancer prevention.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Screening first-degree relatives for gastric cancer prevention.* Gastrointest Endosc. 2016 Jan;83(1):274 Authors: Lachter J PMID: 26706309 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/26cuO2J via IFTTT

Response.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Response.* Gastrointest Endosc. 2016 Jan;83(1):274 Authors: Evans JA, DeWitt JM PMID: 26706308 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SQ7kGs via IFTTT

Primary Gastrointestinal Lymphoma: A Retrospective Multicenter Clinical Study of 415 Cases in Chinese Province of Guangdong and a Systematic Review Containing 5075 Chinese Patients.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Primary Gastrointestinal Lymphoma: A Retrospective Multicenter Clinical Study of 415 Cases in Chinese Province of Guangdong and a Systematic Review Containing 5075 Chinese Patients.* Medicine (Baltimore). 2015 Nov;94(47):e2119 Authors: Chen Y, Chen Y, Chen S, Wu L, Xu L, Lian G, Yang K, Li Y, Zeng L, Huang K Abstract Primary gastrointestinal lymphoma (PGIL) is a rare malignant tumor without standard diagnosis and treatment methods. This study is aimed to systematically analyze its clinical characteristics and dra... περισσότερα »

[Rituximab and hypogammaglobulinemia].

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Related Articles *[Rituximab and hypogammaglobulinemia].* Medicina (B Aires). 2015;75(5):319-23 Authors: Fernández Romero DS, Torre MG, Larrauri BJ, Malbrán E, Juri MC, Malbrán A Abstract Rituximab, a chimeric monoclonal antibody against CD20, induces the depletion of B lymphocytes. It is used for the treatment of lymphoproliferative and autoimmune diseases. Antibody immunodeficiency associated to RTX treatment is a new motif for consultation to our service. We decided to study those patients that having been treated with RTX, consulted for hypogammaglobulinemia or recurrent inf...περισσότερα »

Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.* J Clin Oncol. 2015 Nov 20;33(33):3930-7 Authors: Ghesquieres H, Slager SL, Jardin F, Veron AS, Asmann YW, Maurer MJ, Fest T, Habermann TM, Bene MC, Novak AJ, Mareschal S, Haioun C, Lamy T, Ansell SM, Tilly H, Witzig TE, Weiner GJ, Feldman AL, Dogan A, Cunningham JM, Olswold CL, Molina TJ, Link BK, Milpied N, Cox DG, Salles GA, Cerhan JR Abstract PURPOSE: We performed a multistage genome-wide asso...περισσότερα »

Evidence to Support a Contribution of Polyreactive Antibodies to HLA Serum Reactivity.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Evidence to Support a Contribution of Polyreactive Antibodies to HLA Serum Reactivity.* Transplantation. 2016 Jan;100(1):217-26 Authors: Gao B, Rong C, Porcheray F, Moore C, Girouard TC, Saidman SL, Wong W, Fu Y, Zorn E Abstract BACKGROUND: Assessing the serum reactivity to HLA is essential for the evaluation of transplant candidates and the follow-up of allograft recipients. In this study, we look for evidence at the clonal level that polyreactive antibodies cross-reactive to apoptotic cells and multiple autoan... περισσότερα »

High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: Final Results of a Multicenter Phase II Trial.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: Final Results of a Multicenter Phase II Trial.* J Clin Oncol. 2015 Nov 20;33(33):3903-10 Authors: Ferreri AJ, Donadoni G, Cabras MG, Patti C, Mian M, Zambello R, Tarella C, Di Nicola M, D'Arco AM, Doa G, Bruno-Ventre M, Assanelli A, Foppoli M, Citterio G, Fanni A, Mulè A, Caligaris-Cappio F, Ciceri F Abstract PURPOSE: Tr...περισσότερα »

Primary diffuse large B-cell lymphoma of the central nervous system in pineal gland: Report of a rare case with review of literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1SpEjV4] Related Articles *Primary diffuse large B-cell lymphoma of the central nervous system in pineal gland: Report of a rare case with review of literature.* Indian J Pathol Microbiol. 2015 Jul-Sep;58(3):412-3 Authors: Vasudevan JA, Nair RA, Nair SG, Prahlada A PMID: 26275286 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1PeqeGQ via IFTTT

Primary extranodal non-Hodgkin lymphoma: A 3-year record-based descriptive study from a tertiary care center in Southern India.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1SpEjV4] Related Articles *Primary extranodal non-Hodgkin lymphoma: A 3-year record-based descriptive study from a tertiary care center in Southern India.* Indian J Pathol Microbiol. 2015 Jul-Sep;58(3):296-300 Authors: Mishra P, Das S, Kar R, Jacob SE, Basu D Abstract INTRODUCTION: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes and even from sites, which normally do not contain lymphoid tissue. This study was undertaken to ascertain the prevalence, anatomical distribution, and histological s... περισσότερα »

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.* Oncotarget. 2015 Jun 20;6(17):14796-813 Authors: Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J Abstract In searching for small-molecule compounds that inhibit proliferation and survival of diffuse large B-cell lympho... περισσότερα »

Ratios of Four STAT3 Splice Variants in Human Eosinophils and Diffuse Large B Cell Lymphoma Cells.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Ratios of Four STAT3 Splice Variants in Human Eosinophils and Diffuse Large B Cell Lymphoma Cells.* PLoS One. 2015;10(5):e0127243 Authors: Turton KB, Annis DS, Rui L, Esnault S, Mosher DF Abstract Signal transducer and activator of transcription 3 (STAT3) is a key mediator of leukocyte differentiation and proliferation. The 3' end of STAT3 transcripts is subject to two alternative splicing events. One results in either full-length STAT3α or in STAT3β, which lacks part of the C-terminal ... περισσότερα »

Follicular lymphoma evolving into diffuse large B-cell lymphoma with Reed-Sternberg like cells.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1SpEjV4] Related Articles *Follicular lymphoma evolving into diffuse large B-cell lymphoma with Reed-Sternberg like cells.* Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):261-2 Authors: Sancheti S, Arora N, Sawaimoon S, Chakrapani A PMID: 25885156 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1O2FxpR via IFTTT

Anaplastic lymphoma kinase-positive large B-cell lymphoma: a potential diagnostic pitfall.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--http://ift.tt/1SpEjV4] Related Articles *Anaplastic lymphoma kinase-positive large B-cell lymphoma: a potential diagnostic pitfall.* Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):241-5 Authors: Yu H, Huang J, Sun J, Wang C, Lin M, Li H Abstract Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK + LBCL) is a rare variant of LBCL with an abnormal immunophenotype, which is easily misdiagnosed as carcinoma or plasma cell neoplasm. Here, we present two cases of ALK + LBCL in the lymph node; describe their clinical, pathological, and immunophenotype features;... περισσότερα »

Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--pubs.acs.org-images-pubmed-acspub] Related Articles *Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation.* Mol Pharm. 2015 Jun 1;12(6):1703-16 Authors: Hong EE, Erickson H, Lutz RJ, Whiteman KR, Jones G, Kovtun Y, Blanc V, Lambert JM Abstract Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of t... περισσότερα »

Brainstem lymphoma in a myasthenia gravis patient on azathioprine.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Brainstem lymphoma in a myasthenia gravis patient on azathioprine.* J Clin Neurosci. 2015 Feb;22(2):415-8 Authors: Termsarasab P, Katirji B Abstract Azathioprine is used for immunosuppression in myasthenia gravis (MG). We report a patient with seropositive MG who developed a brainstem lymphoma 4 years after being treated with azathioprine and review the literature on the occurrence of lymphoma in this patient population. An 82-year-old man with ocular MG who had been on azathioprine for 4 years developed subacute ... περισσότερα »

Desflurane on postoperative olfactory memory

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
The effect of *OBJECTIVE: *In this study, we investigated the effects of desflurane 6%, on olfactory memory. *PATIENTS AND METHODS: *This is a prospective clinical study performed with 40 patients aged 18-60 who had elective surgery and American Society of Anesthesiologists (ASA) physical status I-III. The Brief Smell Identification Test (BSIT) was used for evaluating patients’ olfactory memories before and after the surgery. Patients received standard general anesthesia protocol and routine monitoring. For induction, 1.5 mg/kg of fentanyl, 2 mg/kg of propofol, and 0.5 mg/kg of ... περισσότερα »

Proteome-analysis identifies L1CAM / CD171 and DPP4 / CD26 as novel markers of human skin mast cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Proteome-analysis identifies L1CAM / CD171 and DPP4 / CD26 as novel markers of human skin mast cells: [image: cover.gif?v=1&s=eca9898eab49b7d92da2055c] Abstract Background The function of skin mast cells has been well documented in IgE-mediated allergic reactions whereas other mast cell functions are poorly defined. The present study aimed at identifying novel mast cell proteins by proteome analysis of primary human skin mast cells. Methods The proteome of skin mast cells was compared to other cell types and analyzed using bioinformatics. The expression and function of two protei... περισσότερα »

Systemic mastocytosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Patient reported disease-specific quality of life and symptom severity in systemic mastocytosis: [image: cover.gif?v=1&s=eca9898eab49b7d92da2055c] Abstract Background Presently, no validated data exists on symptom severity and disease-specific quality of life (QoL) for mastocytosis patients. Simultaneously, clinical trials and drug application processes increasingly mandate reporting patients’ perspectives on symptoms and QoL. We report on the development and validation of the mastocytosis quality of life questionnaire (MQLQ) and the mastocytosis symptom assessment form (MSAF). ...περισσότερα »

Poor Performance of the Chlamydia Rapid Test Device for the Detection of Asymptomatic Infections in South African Men: A Pilot Study

Background. To the best of our knowledge, there have been no published reports on the diagnostic performance of the Chlamydia Rapid Test (CRT) Device for male urine samples. We evaluated the performance of the CRT Device when compared with that of the BD ProbeTec ET PCR Assay in a population of asymptomatic men. Methods. The […]

The Effect of Diabetes Medication on Cognitive Function: Evidence from the PATH Through Life Study

Objective. To examine the effect of diabetes treatment on change of measures of specific cognitive domains over 4 years. Research Design and Methods. The sample was drawn from a population-based cohort study in Australia (the PATH Through Life Study) and comprised 1814 individuals aged 65–69 years at first measurement, of whom 211 were diagnosed with […]

Appraisals of Salient Visual Elements in Web Page Design

Visual elements in user interfaces elicit emotions in users and are, therefore, essential to users interacting with different software. Although there is research on the relationship between emotional experience and visual user interface design, the focus has been on the overall visual impression and not on visual elements. Additionally, often in a software development process, […]

Reticulated, Hyperchromic Rash in a Striated Pattern Mimicking Atopic Dermatitis and Fungal Infection in a 2-Month-Old Female: A Case of Incontinentia Pigmenti

We present a 12-month-old Hispanic female with a reticulated, hyperchromic rash in a striated pattern appearing on upper and lower extremities and trunk and back since the age of 6 weeks. Over the next 10 months, the rash persisted. The rash did not respond to treatment with antifungals and steroids. During her 6-month wellness visit, […]

IJERPH, Vol. 13, Pages 432: Associations of Extrinsic and Intrinsic Components of Work Stress with Health: A Systematic Review of Evidence on the Effort-Reward Imbalance Model

Mainstream psychological stress theory claims that it is important to include information on people’s ways of coping with work stress when assessing the impact of stressful psychosocial work environments on health. Yet, some widely used respective theoretical models focus exclusively on extrinsic factors. The model of effort-reward imbalance (ERI) differs from them as it explicitly […]

IJERPH, Vol. 13, Pages 430: Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses

The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. […]

IJERPH, Vol. 13, Pages 433: Up-Regulation of Long Non-Coding RNA AB073614 Predicts a Poor Prognosis in Patients with Glioma

Dysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially in cancer. Emerging evidence indicates that dysregulated lncRNAs are implicated in tumorigenesis and cancer progression. LncRNA AB073614 characterized as a new candidate lncRNA promotes the development of ovarian cancer. However, the role of lncRNA AB073614 in human gliomas remains unknown. The expression of […]

Exposure To Asbestos – TheSequitur.com

Exposure To Asbestos TheSequitur.com This disease has been found to exist in other organs of the body as well such as the larynx, pancreas and colon, but those instances are extremely limited compared to lung cancer incidents. The chance of developing mesothelioma is in direct proportion … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SWRES5 […]

The roughness of lip skin is related to the ceramide profile in the stratum corneum

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
The roughness of lip skin is related to the ceramide profile in the stratum corneum: Abstract Objective The structure of skin on the lips is different from skin at other areas of the body, the water content of the stratum corneum (SC) and the barrier function there is low. Therefore, the lips can easily become dry and rough. The SC plays an important role in the barrier and water-holding functions of the skin. Above all, ceramides (CERs) are important SC lipids which maintain SC functions. The purpose of this study was to clarify the relationship between the degree of lip roughness... περισσότερα »

Oral potentially malignant disorders in rural workers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Prevalence and factors associated with oral potentially malignant disorders in Brazil′s rural workers: [image: cover.gif?v=1&s=5b5fc3d9498c5386f9d6bb06] Abstract Objectives Determine the prevalence of Oral Potentially Malignant Disorders in a population of rural workers in the northeast of Brazil and investigate the association with socio-demographic, occupational and health factors. Methods 1385 workers answered a validated questionnaire and were examined by calibrated dentists. A descriptive analysis, chi-square homogeneity test and binary logistic regression were performed. Re... περισσότερα »

Sensory neuronal hearing loss, in both sexes and premature ovarian failure or infertility in females

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Novel missense mutation in the CLPP gene causes Perrault Syndrome type-3 J Clin Res Pediatr Endocrinol. 2016 Apr 18; Authors: Dursun F, Mohamoud HS, Karim N, Naeem M, Jelani M, Kırmızıbekmez H Abstract Perrault syndrome (PRLTS) is a heterogeneous group of clinical and genetic disorders in which patients are characterized by sensory neuronal hearing loss, in both sexes and premature ovarian failure or infertility in females. Neurological and hearing loss symptoms appear early in life; however, female infertility obviously cannot be detected before puberty. In addition to this, spast... περισσότερα »

Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.* Br J Clin Pharmacol. 2015 Aug;80(2):200-8 Authors: Cohen S, Bueno de Mesquita M, Mimouni FB Abstract Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present ar... περισσότερα »

Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.* J Vet Intern Med. 2014 Nov-Dec;28(6):1716-23 Authors: Kook PH, Kempf J, Ruetten M, Reusch CE Abstract BACKGROUND: Although gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption. OBJECTIVES: To monitor esophageal pH with the Bravo pH system in healthy dogs and client-owned dogs display... περισσότερα »

Swallowing Disorders in Severe Brain Injury in the Arousal Phase

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Abstract The objective of this study was to determine the clinical characteristics of swallowing disorders in severe brain injury in the arousal phase after coma. Between December 1, 2013 and June 30, 2014, eleven patients with severe acquired brain injury who were admitted to rehabilitation center (Male 81.8 %; 40.7 ± 14.6 years) were included in the study. Evaluation of swallowing included a functional examination, clinical functional swallowing test, and naso-endoscopic swallowing test. All patients had swallowing disorders at admission. The first functional swallowing test sho... περισσότερα »

Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.* Keio J Med. 2015;64(3):48-50 Authors: Sugiura Y, Nakagawa M, Hashizume T, Nemoto E, Kaseda S PMID: 26411779 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1qVSPuq

Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.* Am J Surg. 2016 Jan;211(1):250-67 Authors: Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ Abstract BACKGROUND: The effect of sleeve gastrectomy (SG) on the prevalence of gastroesophageal reflux disease (GERD) remains unclear. We aimed to outline the currently available literature. DATA SOURCES: All relevant databases were searched for publications examining the effect of laparoscopic SG on GERD. Primary outcome measu... περισσότερα »

A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Related Articles *A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.* Gen Dent. 2015 Sep-Oct;63(5):e12-7 Authors: Metz MJ, Stapleton BM, Harris BT, Lin WS Abstract This case report describes preventive and restorative treatment planning for a 56-year-old female patient with severe, chronic, poorly controlled gastroesophageal reflux disease and resulting loss of vertical dimension of occlusion. First, the demineralization process was controlled through collaboration with the pat... περισσότερα »

[Congenital alacrima revealing a Allgrove syndrome: report of three cases].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Congenital alacrima revealing a Allgrove syndrome: report of three cases].* Pan Afr Med J. 2015;20:359 Authors: Derrar R, Boutimzine N, Laghmari A, Alouane A, Daoudi R PMID: 26185551 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/20TeC2k

[Why oesophageal adenocarcinoma is occurring more frequently].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--http://ift.tt/1PjZjdS] Related Articles *[Why oesophageal adenocarcinoma is occurring more frequently].* Ned Tijdschr Geneeskd. 2015;159:A8915 Authors: Doorakkers E, Brusselaers N Abstract The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk factors that might account for this rising incidence are reflux, obesity and the absence of Helicobacter pylori. Oesophageal adenocarcinoma is 9 times more likely in men than i... περισσότερα »

Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).* J Vet Emerg Crit Care (San Antonio). 2015 May-Jun;25(3):405-12 Authors: Olan NV, Prittie J Abstract OBJECTIVE: To describe the use of ProcalAmine as a source of parenteral nutrition in hospitalized dogs and to report complications possibly referable to its use. DESIGN: Retrospective study. SETTINGS: Private veterinary teaching hospital. ANIMALS: Thirty-six dogs hospitalized in ICU receiving ProcalA... περισσότερα »

Minor Disorders of Esophageal Peristalsis: Highly Prevalent Minimally Relevant?

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Minor Disorders of Esophageal Peristalsis: Highly Prevalent, Minimally Relevant?* Clin Gastroenterol Hepatol. 2015 Aug;13(8):1424-5 Authors: Bredenoord AJ PMID: 25796576 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1re5x8u

Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.* Br J Clin Pharmacol. 2015 Aug;80(2):200-8 Authors: Cohen S, Bueno de Mesquita M, Mimouni FB Abstract Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present art... περισσότερα »

Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.* J Vet Intern Med. 2014 Nov-Dec;28(6):1716-23 Authors: Kook PH, Kempf J, Ruetten M, Reusch CE Abstract BACKGROUND: Although gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption. OBJECTIVES: To monitor esophageal pH with the Bravo pH system in healthy dogs and client-owned dogs displayi... περισσότερα »

Swallowing Disorders in Severe Brain Injury in the Arousal Phase

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Abstract The objective of this study was to determine the clinical characteristics of swallowing disorders in severe brain injury in the arousal phase after coma. Between December 1, 2013 and June 30, 2014, eleven patients with severe acquired brain injury who were admitted to rehabilitation center (Male 81.8 %; 40.7 ± 14.6 years) were included in the study. Evaluation of swallowing included a functional examination, clinical functional swallowing test, and naso-endoscopic swallowing test. All patients had swallowing disorders at admission. The first functional swallowing test show... περισσότερα »

Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.* Keio J Med. 2015;64(3):48-50 Authors: Sugiura Y, Nakagawa M, Hashizume T, Nemoto E, Kaseda S PMID: 26411779 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1qVSPuq via IFTTT

Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.* Am J Surg. 2016 Jan;211(1):250-67 Authors: Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ Abstract BACKGROUND: The effect of sleeve gastrectomy (SG) on the prevalence of gastroesophageal reflux disease (GERD) remains unclear. We aimed to outline the currently available literature. DATA SOURCES: All relevant databases were searched for publications examining the effect of laparoscopic SG on GERD. Primary outcome meas... περισσότερα »

A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Related Articles *A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.* Gen Dent. 2015 Sep-Oct;63(5):e12-7 Authors: Metz MJ, Stapleton BM, Harris BT, Lin WS Abstract This case report describes preventive and restorative treatment planning for a 56-year-old female patient with severe, chronic, poorly controlled gastroesophageal reflux disease and resulting loss of vertical dimension of occlusion. First, the demineralization process was controlled through collaboration with the pa... περισσότερα »

[Congenital alacrima revealing a Allgrove syndrome: report of three cases].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Congenital alacrima revealing a Allgrove syndrome: report of three cases].* Pan Afr Med J. 2015;20:359 Authors: Derrar R, Boutimzine N, Laghmari A, Alouane A, Daoudi R PMID: 26185551 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/20TeC2k via IFTTT

[Why oesophageal adenocarcinoma is occurring more frequently].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--http://ift.tt/1PjZjdS] Related Articles *[Why oesophageal adenocarcinoma is occurring more frequently].* Ned Tijdschr Geneeskd. 2015;159:A8915 Authors: Doorakkers E, Brusselaers N Abstract The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk factors that might account for this rising incidence are reflux, obesity and the absence of Helicobacter pylori. Oesophageal adenocarcinoma is 9 times more likely in men than ... περισσότερα »

Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).* J Vet Emerg Crit Care (San Antonio). 2015 May-Jun;25(3):405-12 Authors: Olan NV, Prittie J Abstract OBJECTIVE: To describe the use of ProcalAmine as a source of parenteral nutrition in hospitalized dogs and to report complications possibly referable to its use. DESIGN: Retrospective study. SETTINGS: Private veterinary teaching hospital. ANIMALS: Thirty-six dogs hospitalized in ICU receiving Procal... περισσότερα »

Minor Disorders of Esophageal Peristalsis: Highly Prevalent, Minimally Relevant?

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Minor Disorders of Esophageal Peristalsis: Highly Prevalent, Minimally Relevant?* Clin Gastroenterol Hepatol. 2015 Aug;13(8):1424-5 Authors: Bredenoord AJ PMID: 25796576 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1re5x8u via IFTTT

Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.* Br J Clin Pharmacol. 2015 Aug;80(2):200-8 Authors: Cohen S, Bueno de Mesquita M, Mimouni FB Abstract Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present ar... περισσότερα »

Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.* J Vet Intern Med. 2014 Nov-Dec;28(6):1716-23 Authors: Kook PH, Kempf J, Ruetten M, Reusch CE Abstract BACKGROUND: Although gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption. OBJECTIVES: To monitor esophageal pH with the Bravo pH system in healthy dogs and client-owned dogs display... περισσότερα »

Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.* Keio J Med. 2015;64(3):48-50 Authors: Sugiura Y, Nakagawa M, Hashizume T, Nemoto E, Kaseda S PMID: 26411779 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1qVSPuq

Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.* Am J Surg. 2016 Jan;211(1):250-67 Authors: Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ Abstract BACKGROUND: The effect of sleeve gastrectomy (SG) on the prevalence of gastroesophageal reflux disease (GERD) remains unclear. We aimed to outline the currently available literature. DATA SOURCES: All relevant databases were searched for publications examining the effect of laparoscopic SG on GERD. Primary outcome measu... περισσότερα »

A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Related Articles *A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.* Gen Dent. 2015 Sep-Oct;63(5):e12-7 Authors: Metz MJ, Stapleton BM, Harris BT, Lin WS Abstract This case report describes preventive and restorative treatment planning for a 56-year-old female patient with severe, chronic, poorly controlled gastroesophageal reflux disease and resulting loss of vertical dimension of occlusion. First, the demineralization process was controlled through collaboration with the pat... περισσότερα »

Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).* J Vet Emerg Crit Care (San Antonio). 2015 May-Jun;25(3):405-12 Authors: Olan NV, Prittie J Abstract OBJECTIVE: To describe the use of ProcalAmine as a source of parenteral nutrition in hospitalized dogs and to report complications possibly referable to its use. DESIGN: Retrospective study. SETTINGS: Private veterinary teaching hospital. ANIMALS: Thirty-six dogs hospitalized in ICU receiving Procal... περισσότερα »

Minor Disorders of Esophageal Peristalsis: Highly Prevalent, Minimally Relevant?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Minor Disorders of Esophageal Peristalsis: Highly Prevalent, Minimally Relevant?* Clin Gastroenterol Hepatol. 2015 Aug;13(8):1424-5 Authors: Bredenoord AJ PMID: 25796576 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1re5x8u via IFTTT

Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.* Br J Clin Pharmacol. 2015 Aug;80(2):200-8 Authors: Cohen S, Bueno de Mesquita M, Mimouni FB Abstract Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present ar... περισσότερα »

Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux.* J Vet Intern Med. 2014 Nov-Dec;28(6):1716-23 Authors: Kook PH, Kempf J, Ruetten M, Reusch CE Abstract BACKGROUND: Although gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption. OBJECTIVES: To monitor esophageal pH with the Bravo pH system in healthy dogs and client-owned dogs display... περισσότερα »

Monoclonal antibody-based therapies in the treatment of acute lymphoblastic leukemia.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--file.asco.org-Ed_Book-EdBk2013_be] Related Articles *Monoclonal antibody-based therapies in the treatment of acute lymphoblastic leukemia.* Am Soc Clin Oncol Educ Book. 2013;:294-9 Authors: Litzow MR Abstract Recent studies have suggested that pediatric-intensive chemotherapy regimens can improve outcomes in adults with acute lymphoblastic leukemia (ALL) up to the age of 45. Above this age, toxicities increase. Monoclonal antibody-based therapies bring the promise of increased response rates without excessive toxicity. The addition of rituximab to combination chem... περισσότερα »

Individualizing treatment decisions for older adults with hematologic malignancies.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--file.asco.org-Ed_Book-EdBk2013_be] Related Articles *Individualizing treatment decisions for older adults with hematologic malignancies.* Am Soc Clin Oncol Educ Book. 2013;:208-19 Authors: Klepin HD, Rizzieri D, Palumbo A, Magarotto V, Eichhorst B Abstract Hematologic malignancies are a common cause of morbidity and mortality among older adults, who represent the majority of patients diagnosed with these diseases. Treatment options and disease outcomes have improved in recent years because of the development of novel treatment strategies and the design of elderly-s... περισσότερα »

Swallowing Disorders in Severe Brain Injury in the Arousal Phase

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract The objective of this study was to determine the clinical characteristics of swallowing disorders in severe brain injury in the arousal phase after coma. Between December 1, 2013 and June 30, 2014, eleven patients with severe acquired brain injury who were admitted to rehabilitation center (Male 81.8 %; 40.7 ± 14.6 years) were included in the study. Evaluation of swallowing included a functional examination, clinical functional swallowing test, and naso-endoscopic swallowing test. All patients had swallowing disorders at admission. The first functional swallowing test sho... περισσότερα »

Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Iron Supplementation Improved Dysphagia Related to Plummer-Vinson Syndrome.* Keio J Med. 2015;64(3):48-50 Authors: Sugiura Y, Nakagawa M, Hashizume T, Nemoto E, Kaseda S PMID: 26411779 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1qVSPuq via IFTTT

Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis.* Am J Surg. 2016 Jan;211(1):250-67 Authors: Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ Abstract BACKGROUND: The effect of sleeve gastrectomy (SG) on the prevalence of gastroesophageal reflux disease (GERD) remains unclear. We aimed to outline the currently available literature. DATA SOURCES: All relevant databases were searched for publications examining the effect of laparoscopic SG on GERD. Primary outcome meas... περισσότερα »

A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Related Articles *A cost-effective treatment for severe generalized erosion and loss of vertical dimension of occlusion: laboratory-fabricated composite resin restorations.* Gen Dent. 2015 Sep-Oct;63(5):e12-7 Authors: Metz MJ, Stapleton BM, Harris BT, Lin WS Abstract This case report describes preventive and restorative treatment planning for a 56-year-old female patient with severe, chronic, poorly controlled gastroesophageal reflux disease and resulting loss of vertical dimension of occlusion. First, the demineralization process was controlled through collaboration with the pa... περισσότερα »

[Congenital alacrima revealing a Allgrove syndrome: report of three cases].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Congenital alacrima revealing a Allgrove syndrome: report of three cases].* Pan Afr Med J. 2015;20:359 Authors: Derrar R, Boutimzine N, Laghmari A, Alouane A, Daoudi R PMID: 26185551 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/20TeC2k via IFTTT

[Why oesophageal adenocarcinoma is occurring more frequently].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--http://ift.tt/1PjZjdS] Related Articles *[Why oesophageal adenocarcinoma is occurring more frequently].* Ned Tijdschr Geneeskd. 2015;159:A8915 Authors: Doorakkers E, Brusselaers N Abstract The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk factors that might account for this rising incidence are reflux, obesity and the absence of Helicobacter pylori. Oesophageal adenocarcinoma is 9 times more likely in men than ... περισσότερα »

Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Retrospective evaluation of ProcalAmine administration in a population of hospitalized ICU dogs: 36 cases (2010-2013).* J Vet Emerg Crit Care (San Antonio). 2015 May-Jun;25(3):405-12 Authors: Olan NV, Prittie J Abstract OBJECTIVE: To describe the use of ProcalAmine as a source of parenteral nutrition in hospitalized dogs and to report complications possibly referable to its use. DESIGN: Retrospective study. SETTINGS: Private veterinary teaching hospital. ANIMALS: Thirty-six dogs hospitalized in ICU receiving Procal... περισσότερα »

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