Risk of interactions between complementary and alternative medicine and medication for comorbidities in patients with melanoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Abstract Complementary and alternative medicine (CAM) is used widely among cancer patients. Beside the risk of interaction with cancer therapies, interactions with treatment for comorbidities are an underestimated problem. The aim of this study was to assess prevalence of interactions between CAM and drugs for comorbidities from a large CAM usage survey on melanoma patients […]
Height Assessment in the Dutch-Origin Pediatric Cystic Fibrosis Population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Background: Height evaluation is an integral part of cystic fibrosis (CF) care. Height is compared with reference values by converting it to height-for-age (HFA) z scores. However, HFA z scores do not adjust for genetic potential (ie, target height [TH]), which could result in an incorrect estimation of the height. Materials and Methods: To evaluate […]
Good cholesterol
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 480 (2016). doi:10.1038/ni.3450 Author: Laurie A Dempsey (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23YXUk7 via IFTTT
A dendritic cell subset designed for oral tolerance
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 474 (2016). doi:10.1038/ni.3435 Authors: Reinhard Hinterleitner & Bana Jabri Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a ‘division of labor’ for protective immunity. (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sum5F4 […]
Interferon-induced guanylate-binding proteins in inflammasome activation and host defense
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 481 (2016). doi:10.1038/ni.3440 Authors: Bae-Hoon Kim, Jonathan D Chee, Clinton J Bradfield, Eui-Soon Park, Pradeep Kumar & John D MacMicking (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23YXWs8 via IFTTT
Parallels and differences between innate and adaptive lymphocytes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 490 (2016). doi:10.1038/ni.3432 Authors: Sammy Bedoui, Thomas Gebhardt, Georg Gasteiger & Wolfgang Kastenmüller (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sum5ox via IFTTT
Beyond systems analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 480 (2016). doi:10.1038/ni.3454 Author: Ioana Visan (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23YXTN3 via IFTTT
Spontaneous partial loss of the OT-I transgene
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 471 (2016). doi:10.1038/ni.3411 Authors: Gretchen Harms Pritchard, Eric W Cross, Marjorie Strobel, Stephen C Jameson, Ross M Kedl, Kristin A Hogquist & Christopher A Hunter (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sum5or via IFTTT
Platelet bias with age
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 480 (2016). doi:10.1038/ni.3453 Author: Ioana Visan (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23YXVUU via IFTTT
Myeloid dysfunction in ALS
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Nature Immunology 17, 480 (2016). doi:10.1038/ni.3449 Author: Laurie A Dempsey (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sum5ol via IFTTT
Feel the love — Roxana drama team puts heart, soul into new musical – Alton Telegraph
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Alton Telegraph Feel the love — Roxana drama team puts heart, soul into new musical Alton Telegraph The production team also will be selling “Lion Ears” as a fundraiser for two students connected with the Roxana district who have been diagnosed with cancer. “Team Tristan” and “Kicking Cancer with Collin” will benefit from the proceeds […]
Medical marijuana can be hard to come by for those who actually need it – The Daily Orange
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
The Daily Orange Medical marijuana can be hard to come by for those who actually need it The Daily Orange Currently in New York state, there are only three medical conditions permitted to obtain a medical marijuana license: epilepsy, multiple scoliosis and cancer. In addition, there are only five permitted marijuana producers and 20 … […]
Immunotherapy extends life of head and neck cancer patients in trial – Chron.com
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Chron.com Immunotherapy extends life of head and neck cancer patients in trial Chron.com Head and neck cancers are those that develop in the mouth, tongue and throat. About 48,000 people in the U.S. are diagnosed annually, half of whom are successfully treated with conventional cancer treatment. The prognosis is very poor for the other … […]
A Mucocutaneous Junction for Lip Reconstruction
In-Vitro Development of via Oral and Maxillofacial Surgery Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Gurkan Rasit Bayar, Shiuhyang Kuo, Cynthia L. Marcelo, Stephen E. Feinberg PurposePresentation of a simple and reproducible technique to create, in vitro, a construct containing a mucocutaneous junction (MCJ) with a transitional zone (vermillion) for fabrication of a microvascular prelaminated flap for use in lip reconstruction.Material and MethodsCultured primary human skin keratinocytes and oral mucosal epithelial ... περισσότερα »
Intraoral Superficial Angiomyxoma
A Case Report: AbstractAngiomyxomas are a group of relatively uncommon myxoid mesenchymal tumors associated with a high risk of local recurrence without any metastatic potential. Till date only five cases of intraoral superficial angiomyxoma have been reported. This is a case report of a middle aged Indian male patient diagnosed with superficial angiomyxoma of lower left buccal vestibule.
Partially Thrombosed Internal Maxillary Pseudoaneurysm after Gunshot Wound
Partially Thrombosed Internal Maxillary Pseudoaneurysm after Gunshot Wound: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1582454 A 29-year-old man arrived in our emergency department after being shot on the face. Computed tomography (CT) revealed multiple facial bone fractures along the bullet trajectory. On day 10 of admission, CT angiogram of the neck revealed a partially thrombosed pseudoaneurysm in the parapharyngeal fat pad. The pseudoaneurysm was successfully treated with coil embolization. This report discusses diagnosis and treatment of a partially thrombose... περισσότερα »
Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
We present the results of solid state nuclear magnetic resonance (NMR) experiments on HIV-1 capsid protein (CA) assemblies with three different morphologies, namely wild-type CA (WT-CA) tubes with 35-60 nm diameters, planar sheets formed by the Arg18-Leu mutant (R18L-CA), and R18L-CA spheres with 20-100 nm diameters. The experiments are intended to elucidate molecular structural variations […]
Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Allergy to the short ragweed (Ambrosia artemisiifolia) pollen is a major health problem. The ragweed allergen repertoire has been recently expanded with the identification of Amb a 11, a new major allergen belonging to the cysteine protease family. To better characterize Amb a 11, a recombinant proform of the molecule with a preserved active site […]
The pH-Dependent Client Release from the Collagen-Specific Chaperone HSP47 is Triggered by a Tandem Histidine Pair Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Heat shock protein 47 is an ER (endoplasmic reticulum) resident collagen-specific chaperone and essential for proper formation of the characteristic collagen triple helix. It preferentially binds to the folded conformation of its clients and accompanies them from the ER to the Golgi compartment where it releases them and is recycled back to the ER. Unlike […]
Central mechanisms mediating thrombospondin-4 induced pain states Neurobiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Peripheral nerve injury induces increased expression of thrombospondin-4 (TSP4) in spinal cord and dorsal root ganglia (DRG) that contributes to neuropathic pain states through unknown mechanisms. Here, we test the hypothesis that TSP4 activates its receptor, the voltage-gated calcium channel Cavα2δ1 subunit (Cavα2δ1), on sensory afferent terminals in dorsal spinal cord to promote excitatory synaptogenesis […]
Orphan Nuclear Receptor NR4A1 binds a novel protein interaction site on anti-apoptotic B-cell lymphoma gene-2 family proteins Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
B-cell lymphoma gene-2 (Bcl-2) family proteins are key regulators of programmed cell death and important targets for drug discovery. Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modulate their activities, in large part, through protein interactions involving a motif known as BH3 (Bcl-2 Homology 3). Nur77 is an orphan member of the nuclear receptor family that […]
Traditional medicine used in childbirth and for childhood diarrhoea in Nigeria’s Cross River State: interviews with traditional practitioners and a statewide cross-sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Objectives Examine factors associated with use of traditional medicine during childbirth and in management of childhood diarrhoea. Design Cross-sectional cluster survey, household interviews in a stratified last stage random sample of 90 census enumeration areas; unstructured interviews with traditional doctors. Setting Oil-rich Cross River State in south-eastern Nigeria has 3.5 million residents, most of whom […]
Case of unilateral epidermal nevi without extracutaneous anomalies
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
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Multiple courses of pulse corticosteroid therapy for alopecia areata
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract Various systemic corticosteroid therapies are used for alopecia areata (AA). Pulse therapy using methylprednisolone is a treatment approach for AA. The efficacy of multiple courses of pulse therapy for various severities of AA was evaluated. AA patients with less than 50% hair loss, less than or equal to 6 months after AA onset, needed […]
Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qYgWsr via IFTTT
Four novel ATP2C1 mutations in Chinese patients with Hailey–Hailey disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract Hailey–Hailey disease (HHD) is a kind of autosomal dominant dermatosis. The ATP2C1 gene has been identified as the pathogenic gene of HHD since 2000. In this study, direct DNA sequencing was used to identify ATP2C1 gene mutations in four Chinese families and two sporadic cases with HHD. The entire coding and flanking intronic sequences […]
Extensive Cervicomediastinal Emphysema from Mastoid Injury
Extensive Cervicomediastinal Emphysema from Mastoid Injury: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1582460 Traumatic cervicomediastinal emphysema resulting from isolated head trauma is a rare occurrence. Herein, we describe a patient who sustained a closed mastoid injury after being struck with a batted baseball, resulting in acute extensive cervicomediastinal emphysema. Upon further assessment, the patient's aerodigestive tract was determined to have remained intact and unaffected by the injury. The source of soft-tissue air originated from the fractured mast...περισσότερα »
Lamotrigine-induced severe cutaneous adverse reaction
Update data from 1999-2014.: [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY Abstract We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions. We identified a total of 70 patients (42 SJS, five SJS/TEN, 23 TEN). The female to male ratio was 2.83:1 in the TEN group and 1.47:1 in the SJS group. Patients in the TEN group were younger than in... περισσότερα »
Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens
Fine Tuning of a Type 1 Interferon Antagonist.: [image: http:--www.plosone.org-images-pone_120x3] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Urin V, Levin D, Sharma N, Harari D, Schreiber G Abstract Type I interferons are multi-potent cytokines that serve as first line of defense against viruses and other pathogens, posses immunomudolatory functions and elicit a growth inhibitory response. In recent years it has been shown that interferons are also detrimental, for example in lupus, AIDS, tuberculosis and cognitive decline, highlighted the need to develop interfer... περισσότερα »
Anaesthesiology Intensive Therapy
Urinary tract infections in intensive care unit patients — a single-centre, 3-year observational study according to the INICC project *Background:* Urinary tract infections (UTI) in patients with urinary catheters could be a serious complication of hospitalisation in the intensive care unit (ICU). *Methods:* A prospective study (01.01.2012−31.12.2014) was conducted in the 20-bed ICU of the University Hospital in Wroclaw, Poland. The frequency (density, incidence) and aetiology of UTI as well as prophylactic method compliance were estimated in patients of the ICU according to the INIC... περισσότερα »
Toxic epidermal necrosis (TEN) : The use of plasmapheresis
The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis. Anaesthesiol Intensive Ther. Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Głowacka M, Ożóg-Zabolska I Abstract BACKGROUND: Toxic epidermal necrosis (TEN) is a severe and life-threatening syndrome manifesting as extensive necrosis of the epidermis and mucous membranes accompanied by systemic symptoms. The causative factor is exposure to drugs, such as sulphonamides, antiepileptic preparations, non-steroidal anti-inflammatory drugs and paracetamol. The mechanism leading to the development of lesions is unkn... περισσότερα »
Lyell's syndrome : Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN),
Toxic epidermal necrolysis.: Anaesthesiol Intensive Ther. Authors: Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, are rare, life- -threatening diseases that are characterised by extensive epidermal detachment, erosion of mucous membranes and severe systemic symptoms. In the majority of cases, the development of symptoms can be attributed to the use of drugs; therefore, the disease pathology is thought to be caused by a severe adverse reaction to drugs. The high morta...περισσότερα »
Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.
Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells.: J Biophotonics. 2016 Apr 18; Authors: Dias Schalch T, Porta Santos Fernandes K, Costa-Rodrigues J, Pereira Garcia M, Agnelli Mesquita-Ferrari R, Kalil Bussadori S, Fernandes MH Abstract The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (PBM... περισσότερα »
Collection of Plasma Samples for Squamous Cell Carcinoma of the Head and Neck Patients
Collection of Plasma Samples for Squamous Cell Carcinoma of the Head and Neck Patients: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Intervention*: Other: Plasma samples *Sponsor*: Cliniques universitaires Saint-Luc- Université Catholique de Louvain Groups/CohortsAssigned Interventions No treatment Patients with squamous cell carcinoma of the head and neck, targeted therapies, plasma samples: - Group 1 = patients treated with radiation therapy and cetuximab according to Bonner et al [11] - Group 2 = patients treated with cetuximab in combination with ...περισσότερα »
Grade 3 and 4 fatigue (53.8%), nausea (50.8%), neutropenia (47.7%), anemia (37.1%), leukopenia (46.2%), thrombocytopenia (34.1%), diarrhea (32.6%), vomiting (34.8%), lymphocytes count decreased (30.3%), anorexia (21.2%), hyperglycemia (21.2%), constipation (19.7%), hypoalbuminemia (18.9%), dyspnea (18.2%) and cough (16.7%). : LEE011plus Cetuximab in Patients With a Cancer of the Head and Neck
Study of Squamous Cell Carcinoma of the Head and Neck *Intervention*: Drug: LEE011 *Sponsor*: Cliniques universitaires Saint-Luc- Université Catholique de Louvain ArmsAssigned Interventions Experimental: Group I The patients will receive the same molecules (cetuximab and LEE011) but this phase I study will determine the DLTs by dose escalation of LEE011 (400 mg and 600mg). Drug: LEE011 The first 12 patients will receive cetuximab associated with LEE011 at doses of 400 mg and 600 mg daily to determine the DLTs and safety. In the expansion part, besides safety, objective respon... περισσότερα »
E-cigarettes in ENT
Review ArticleE-cigarettes in ENT: what do we need to know?N Stobbsa1 c1, A Lillisa2 and N Kumara3 a1 Department of Otolaryngology and Head and Neck Surgery, Barnsley Hospital NHS Foundation Trust, Camberley, UK a2 Department of Respiratory Medicine, Frimley Park Hospital NHS Foundation Trust, Camberley, UK a3 Department of Otolaryngology and Head and Neck Surgery, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK Abstract Background: E-cigarette use in the UK is increasing and we are commonly encountering patients in the ENT clinic who are e-cigarette smokers. Currently, ... περισσότερα »
Prevention and management of hearing loss in syndromic craniosynostosis
: A case series via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Elisa Biamino, Andrea Canale, Michelangelo Lacilla, Annalisa Marinosci, Federico Dagna, Lorenzo Genitori, Paola Peretta, Margherita Silengo, Roberto Albera, Giovanni Battista Ferrero ObjectiveTo assess the audiological profile in a cohort of children affected by syndromic craniosynostosis.MethodsEleven children with Apert syndrome (n=4), Saethre-Chotzen syndrome (n=3), Muenke syndrome (n=2), Crouzon ... περισσότερα »
Antibiotic resistance in pathogens causing acute otitis media
in Finnish children via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Saara Sillanpää, Markku Sipilä, Heikki Hyöty, Markus Rautiainen, Jussi Laranne IntroductionMicrobiology and susceptibility of middle ear pathogens in children change over time and antibiotic resistance is increasing globally. For the clinicians it is important to be up to date about the resistance situation when considering antibiotic treatment in acute otitis media (AOM). In this study we analy...περισσότερα »
Post intubation Laryngeal injuries in a pediatric
“ intensive care unit of tertiary hospital in India: A Fibreoptic endoscopic study” via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Bhartendu Bharti, Kamran Asif Syed, Kala Ebenezer, Ajoy Mathew Varghese, Mary Kurien Study objectivesTo identify acute laryngeal injuries among pediatric patients intubated for more than 48hours, and to correlate these injuries with clinical variables.SettingPediatric Intensive Care Unit (PICU) of a tertiary level hospital in India.P... περισσότερα »
Topical antiseptic eardrops against methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa
Comparative antibacterial activity of via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Cha Kyung Youn, Sook-Jin Jang, Eu-Ri Jo, Ji Ae Choi, Ju-Hwan Sim, Sung Il Cho ObjectiveAural irrigation using antiseptic solutions can be an effective medical treatment of chronic suppurative otitis media (CSOM) owing to the increasing prevalence of antibiotic-resistant CSOM infections. In the present study, we compared the antimicrobial activities of 100% Burow's solution, 50%... περισσότερα »
Residual volume in the cuff of the endotracheal tube
when the pilot balloon is torn off instead of deflated using a syringe via International Journal of Pediatric Otorhinolaryngology Publication date: July 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 86 Author(s): Mineto Kamata, Mumin Hakim, Joseph D. Tobias BackgroundIn recent years, there has been a shift in airway management with the use of cuffed endotracheal tubes (ETT) in pediatric patients. While the use of a syringe to deflate the cuff is generally recommended, anecdotal observations suggest that some healthcare practitioners tear off the pilot bal... περισσότερα »
Contralateral Bimodal Stimulation: A Way to Enhance Speech Performance in Arabic-Speaking Cochlear Implant Patients
Contralateral Bimodal Stimulation: A Way to Enhance Speech Performance in Arabic-Speaking Cochlear Implant Patients: *Background:* The combination of acoustic and electric stimulation as a way to enhance speech recognition performance in cochlear implant (CI) users has generated considerable interest in the recent years. The purpose of this study was to evaluate the bimodal advantage of the FS4 speech processing strategy in combination with hearing aids (HA) as a means to improve low-frequency resolution in CI patients. *Methods:* Nineteen postlingual CI adults were selected to part...περισσότερα »
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report: Ossification of the cochlea was once considered to be a contraindication for cochlear implantation. Advances in cochlear implant technology and coding strategies have led to developments in different surgical procedures to manage cochlear ossification. The endoscopic technique allows a direct approach to the round window and the cochlea, especially in remodeled labyrinth, allowing a better vision of scala tympani. AbstractHypothesis Ossification of the cochlea was once considered to be a contra... περισσότερα »
Thyrogen Co-Pay Assistance Program is available to support patient access to Thyrogen.
*Thyrogen Co-Pay Assistance Program is available to support patient access to Thyrogen.: * *Thyrogen Co-Pay Assistance Program is available to support patient access to Thyrogen. This program helps with out-of-pocket costs that exceed $100 for eligible patients with commercial insurance.* *In addition to Co-Pay Assistance, financial assistance for eligible patients with no insurance or with insurance that does not cover Thyrogen is available. For patients who do not qualify for financial assistance programs, case managers are available to help them connect with independent co-p... περισσότερα »
Asthma and Irritable Bowel Syndrome
Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies: by Te-Chun Shen, Cheng-Li Lin, Chang-Ching Wei, Chia-Hung Chen, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao Background There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database. Methods We conducted two retrospective cohort studies using data obtained from the National Health Ins... περισσότερα »
Perineural invasion is a unique route for tumor dissemination. In basal cell carcinomas, the incidence is low, but increases in advanced cases.
Which features of advanced head and neck basal cell carcinoma are associated with perineural invasion? via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 19 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): André Bandiera de Oliveira Santos, Natalia Martins Magacho de Andrade, Lenine Garcia Brandão, Claudio Roberto Cernea IntroductionPerineural invasion is a unique route for tumor dissemination. In basal cell carcinomas, the incidence is low, but increases in advanced cases. Its importance is recognized but no... περισσότερα »
Increased masked hypertension prevalence in patients with epistaxis
A possible cause of epistaxis: via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 18 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Baran Acar, Bunyamin Yavuz, Erdem Yıldız, Selcuk Ozkan, Mehmet Ayturk, Omer Sen, Onur Sinan Deveci IntroductionEpistaxis and hypertension are frequent conditions in the adult population. Masked hypertension is defined as a clinical condition in which a patient's office blood pressure level is <140/90mmHg, but the ambulatory or home blood pressure readings are in the hypertensi...περισσότερα »
Sonographic scoring of solid thyroid nodules
: effects of nodule size and suspicious cervical lymph node via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 19 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Ozlem Unsal, Meltem Akpinar, Bilge Turk, Irmak Ucak, Alper Ozel, Semra Kayaoglu, Berna Uslu Coskun IntroductionUltrasound is the most frequently used imaging method to evaluate thyroid nodules. Sonographic characteristics of thyroid nodules which are concerning for malignancy are important to define the need for fine needle aspiration biopsy or open... περισσότερα »
Case of unilateral epidermal nevi without extracutaneous anomalies
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1qYgUkv via IFTTT
Multiple courses of pulse corticosteroid therapy for alopecia areata
Abstract Various systemic corticosteroid therapies are used for alopecia areata (AA). Pulse therapy using methylprednisolone is a treatment approach for AA. The efficacy of multiple courses of pulse therapy for various severities of AA was evaluated. AA patients with less than 50% hair loss, less than or equal to 6 months after AA onset, needed 1.9 courses of pulse therapy for vellus hair to develop. On the other hand, AA patients with more than 50% hair loss, less than 6 months after AA onset, needed more courses of pulse therapy for vellus hair to develop. Regardless of the dise...περισσότερα »
Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss
: a meta-analysis via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 19 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Jing Wang, Jun Li, Kang Peng, Zi-Ying Fu, Jia Tang, Ming-Jian Yang, Qi-Cai Chen IntroductionCurrently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL).ObjectiveThe aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL.Methods... περισσότερα »
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss: AbstractLoss of auditory sensory hair cells is the major pathological feature of noise-induced hearing loss (NIHL). Currently, no established clinical therapies for prevention or amelioration of NIHL are available. The absence of treatments is due to our lack of a comprehensive understanding of the molecular mechanisms underlying noise-induced damage. Our previous study indicates that epigenetic modification of histones alters hair cell survival. In this study, we investigated the effect of noise exposure on h... περισσότερα »
Management of arterial injury during endoscopic sinus and skull base surgery
Management of arterial injury during endoscopic sinus and skull base surgery: Purpose of review: The most feared complication during endonasal surgery is a carotid artery injury. The sheep model of carotid injury provides training for this event by giving a realistic endoscopic experience of major vascular injuries and tissue hemostasis. Recent findings: The sheep model of carotid artery injury recreates the narrow nasal confines and high-flow/high-pressure vascular injury accurately reproducing the endoscopic challenges seen in such vascular emergencies. This has led to the devel...περισσότερα »
The tumor microenvironment of laryngeal dysplasia and progression to invasive cancer
Current understanding of the tumor microenvironment of laryngeal dysplasia and progression to invasive cancer: Purpose of review: This review examines the historical tumor progression genetic model of laryngeal carcinomas, from dysplasia to invasive carcinoma and the role of infiltrating immune and inflammatory cells as contributors to this process. Recent findings: Classically, the genetic model of carcinogenesis describes overexpression of oncogenes and/or silencing of tumor suppressor genes which, when combined with exposure to environmental carcinogens over the course of time,...περισσότερα »
Parathyroid carcinoma
Parathyroid carcinoma: Purpose of review: This article highlights recent advances in our understanding of the incidence, epidemiology, clinical presentation, evaluation, diagnosis, treatment, and prognosis of parathyroid carcinoma. Recent findings: The prevalence of parathyroid carcinoma is approximately 0.005% of all cancers. Therefore, parathyroid carcinoma is one of the rarest malignancies known. Patients with parathyroid carcinoma present with clinical symptoms of hypercalcaemia as these cancers are usually hormonally functional. It is not uncommon that patients present with co...περισσότερα »
Early death among head and neck cancer patients
Early death among head and neck cancer patients: Purpose of review: Management of advanced head and neck cancer (HNC) is characterized by high mortality. Furthermore, the treatment involves significant burden to patients and high costs to healthcare systems. Recognizing the risks of early death in patients with a high probability of noncurable disease is important for each individual treatment decision-making. It is thus critical to consider the benefits and side-effects of the planned treatment in relation to the expected survival and to discuss these factors with the patient. Howe... περισσότερα »
Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity?
Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity?: Abstract Purpose of review: Laryngeal cancer published literature was reviewed, with emphasis on reporting on young patients (<40 years). With such information, to comment on the evidence or not, that such patients, should they be nondrinkers and nonsmokers, have a differing cause and genetic/molecular profile rather than a spectrum of the classic disease. Recent findings: Head and neck cancer in young patients is documented at a rate of 0.4–3.6%, with laryngeal cancer being identified in les... περισσότερα »
Early detection of oral cancers: current status and future prospects
Early detection of oral cancers: current status and future prospects: Purpose of review: This article reviews the current literature and summarizes the latest developments in screening and early detection of oral cancers and looks at the future possibilities. Recent findings: Oral cancer is the best model for screening and prevention. The screening for oral cancer can be population based, opportunistic, or targeted. A long-term 15-year follow-up data of a randomized controlled study from a developing country setting indicated a sustained reduction in oral cancer mortality in high-r... περισσότερα »
Endoscopic ultrasound of the larynx
Endoscopic ultrasound of the larynx: Purpose of review: Endoscopic ultrasound (EUS) of the larynx is a vertical endoscopic imaging technique that gives further information about the extension of a lesion apart from normal white light endoscopy, chromoendoscopy, as well as palpation. It combines the advantages of ultrasound and endoscopy. Miniprobes or ultrasound endoscopes with 10–20 MHz are applied. The present review is focused on the use of EUS in the larynx especially in the management of laryngeal cancer. Recent findings: At present, the larynx is routinely assessed by compute... περισσότερα »
Midface prosthetic rehabilitation
Midface prosthetic rehabilitation: Purpose of review: Midfacial defects resulting from head and neck oncological resections can be addressed by microvascular reconstructive techniques using autologous tissue. In specific indications, however, prosthetic rehabilitation can give a superior aesthetic outcome, combined with a less intensive surgical strain on the patient. In other situations, the combination of both approaches can restore much extended defects satisfactorily. This review lists the indications, technical prerequisites for success, and outcome of midface prosthetic rehab... περισσότερα »
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?: Purpose of review: Radiotherapy is one of the most effective treatment modalities for head and neck cancer. However, because of the intricacy between tumors and normal tissues, it can induce morbidity, such as mucositis, dermatitis, xerostomia, dysphagia, hearing loss, vision impairment, skin fibrosis, and osteoradionecrosis of the jaw, and it can dramatically impact on patient quality of life. Recent findings: Throughout the last decade, significant improvements have been made in head and neck cancer radiothera...περισσότερα »
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices: Purpose of review: In this manuscript, we will provide a panorama of the current status of skull base reconstruction following endoscopic endonasal or open resection of malignant lesions, focusing on novel options and recent modifications of previously described techniques. Recent findings: New developments in skull base reconstruction continue to arise, mostly as in the form of vascularized pedicled flaps that can be used following endoscopic and open resections of the sk... περισσότερα »
Reasonable limits for transoral laser microsurgery in laryngeal cancer
Reasonable limits for transoral laser microsurgery in laryngeal cancer: Purpose of review: Transoral laser microsurgery (TLM) is widely acknowledged to offer several advantages in the treatment of early and selected intermediate-advanced laryngeal cancers. Nevertheless, a number of issues are still under debate. The purpose of this review is to discuss the reasonable limits for TLM in laryngeal cancer to highlight its most appropriate and reproducible indications, putting this therapeutic tool in the right perspective within a comprehensive frame of alternative treatment strategies... περισσότερα »
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices: Purpose of review: This article critically analyzes the recent literature on microvascular head and neck reconstruction after (chemo)radiation [(C)RT], taking into consideration both the underlying pathogenetic mechanisms and their clinical consequences. Recent findings: Microvascular reconstruction has gradually become a mainstay in the management of head and neck cancer both in primary and salvage scenarios. However, limited data are available concerning the influence of previous radiotherap... περισσότερα »
Ameloblastomas of the mandible and maxilla
Ameloblastomas of the mandible and maxilla: Purpose of review: This review focuses on issues in managing ameloblastomas of the mandible and maxilla. We will refer to current practice in the treatment of ameloblastomas based on the available evidence. Recent findings: Recent reviews have been trying to establish natural history, growth patterns and malignant potential. This provides the clinicians and the patients with useful prognostic information. Controversies in management of ameloblastomas in relation to the type, age and site exist. This paper aims to categorize these issues. ...περισσότερα »
Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions
Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions: Objective To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. Study Design Case series with chart review. Setting Tertiary referral academic center. Subjects and Methods Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed for 1076 patients. Of these, 343 cases had surgical follow-up (parotid gland, n = 272; submandibular gland, n = 71).... περισσότερα »
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness: Objective Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and to identify primary tumor characteristics that may predict parotid metastasis. Study Design Retrospective case series. Settings Tertiary care center. Subjects and Methods An ...περισσότερα »
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis: Objectives (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. Study Design Retrospective cohort study. Setting Tertiary care. Subjects and Methods Gene expression barcode analysis was applied to an existing publicly available data set of 54 HPV-negative oral cavity squamous cell carcinoma tumor samples to identify candid...περισσότερα »
The Persistence of Tinnitus after Acoustic Neuroma Surgery
The Persistence of Tinnitus after Acoustic Neuroma Surgery: Objective Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects and Methods The records of 166 patients who underwent acoustic neuroma resection from 2009 to 2014 were reviewed. Patients were asked to complete a survey, including the Tinnitus Handicap Inventory, 1 to 6 years postoperatively. Results Of the 53 patients who completed the survey, 17% reported that their tinnitus re...περισσότερα »
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center: There are no approved Food and Drug Administration indications for pediatric auditory brainstem implant (ABI) surgery in the United States. Our prospective case series aims to determine the safety and feasibility of ABI surgery in pediatric patients <5 years old with congenital deafness at a tertiary North American center. The inclusion criterion was pre- or postlinguistic deafness in children not eligible for cochlear implantation. Seventeen candidates were evaluated (mea... περισσότερα »
Tracheostomy-Specific Quality of Life Questionnaire
The Development of a Tracheostomy-Specific Quality of Life Questionnaire: A Pilot Study: Objective: A long-term tracheostomy can be a life-altering event and can have significant effects on patients’ quality of life (QOL). There is currently no instrument available to evaluate tracheostomy-specific QOL. To address this deficiency, the objective of this study was to create and preliminarily validate a pilot tracheostomy-specific QOL questionnaire to assess its feasibility. Methods: A multidisciplinary team developed the pilot tracheostomy-specific QOL questionnaire (TQOL) in 3 phas... περισσότερα »
Military jet noise source imaging
using multisource statistically optimized near-field acoustical holography: [image: cm_sbs_024_plain.png] The identification of acoustic sources is critical to targeted noise reduction efforts for jets on high-performance tactical aircraft. This paper describes the imaging of acoustic sources from a tactical jet using near-field acoustical holography techniques. The measurement consists of a series of scans over the hologram with a dense microphone array. Partial field decomposition methods are performed to generate coherent holograms. Numerical extrapolation of data beyond the m... περισσότερα »
Photoacoustic tomography
Image reconstruction with uncertainty quantification in photoacoustic tomography: [image: cm_sbs_024_plain.png] Photoacoustictomography is a hybrid imaging method that combines optical contrast and ultrasound resolution. The goal of photoacoustictomography is to resolve an initial pressure distribution from detectedultrasound waves generated within an object due to an illumination of a short light pulse. In this work, a Bayesian approach to photoacoustictomography is described. The solution of the inverse problem is derived and computation of the point estimates for image reconstr... περισσότερα »
Labyrinthine concussion following gunshot injury
: A case report: 10.3109/14992027.2016.1166398<br>Jamie M. Bogle Abstract *Objective*: Labyrinthine concussion due to a postauricular gunshot wound has not been well reported. *Design*: Retrospective chart review. *Study sample*: We describe an otherwise healthy 22-year-old male who received a gunshot wound to the left mastoid and subsequently reported hearing loss and rotational vertigo. *Results*: Audiometric testing demonstrated significant inverted scoop shaped sensorineural hearing loss. Vestibular diagnostic testing indicated a significant uncompensated left peripheral ves...περισσότερα »
Transmucosal Gas-Loss Rates in Middle Ears Initially Filled with O2 or CO2
Transmucosal Gas-Loss Rates in Middle Ears Initially Filled with O2 or CO2 via Hearing Research Publication date: Available online 19 April 2016 *Source:*Hearing Research Author(s): Romain E. Kania, Benjamin Verillaud, Bernard Ars, Patrice Tran Ba Huy, Philippe Herman, Amos Ar This study investigates the role of different gases in clearance of gas in the middle ear cavity (ME) by its mucosal blood flow. A rat model was used to measure gas volume changes in the ME cavity at constant pressure without ventilation. We disturbed the normal gas composition of the ME by filling it with O2 or...περισσότερα »
The Intelligibility of Interrupted Speech: Cochlear Implant Users and Normal Hearing Listeners
The Intelligibility of Interrupted Speech: Cochlear Implant Users and Normal Hearing Listeners: AbstractCompared with normal-hearing listeners, cochlear implant (CI) users display a loss of intelligibility of speech interrupted by silence or noise, possibly due to reduced ability to integrate and restore speech glimpses across silence or noise intervals. The present study was conducted to establish the extent of the deficit typical CI users have in understanding interrupted high-context sentences as a function of a range of interruption rates (1.5 to 24 Hz) and duty cycles (50 and ... περισσότερα »
Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Background/aims: Recruitment of subjects is critical to the success of any clinical trial, but achieving this goal can be a challenging endeavor. Volunteer nurse and student enrollers are potentially an important source of recruiters for hospital-based trials; however, little is known of either the efficacy or cost of these types of enrollers. We assessed volunteer […]
A post hoc evaluation of a sample size re-estimation in the Secondary Prevention of Small Subcortical Strokes study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Background/aims: The use of adaptive designs has been increasing in randomized clinical trials. Sample size re-estimation is a type of adaptation in which nuisance parameters are estimated at an interim point in the trial and the sample size re-computed based on these estimates. The Secondary Prevention of Small Subcortical Strokes study was a randomized clinical […]
Promising entrectinib clinical trial data – Science Daily
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Promising entrectinib clinical trial data Science Daily These responses were seen for patients with a variety of types of cancer: NSCLC; colorectal cancer; mammary analog secretory carcinoma of the salivary gland with NTRK1/2/3 gene fusions; NSCLC with ROS1 gene fusions; and NSCLC and colorectal … Dramatic Tumor Responses With Multitargeted TKIMedPage Today all 2 news […]
Study drug LOXO-101 shows tumor regression in varied cancers – Science Daily
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
UPI.com Study drug LOXO-101 shows tumor regression in varied cancers Science Daily Out of 43 patients enrolled in the study, the six with TRK gene fusions had tumors representing cancers such as sarcoma, thyroid, salivary gland, gastrointestinal and non-small cell lung. Five demonstrated partial responses to LOXO-101 and the sixth … Loxo Oncology Shares New […]
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
There are no approved Food and Drug Administration indications for pediatric auditory brainstem implant (ABI) surgery in the United States. Our prospective case series aims to determine the safety and feasibility of ABI surgery in pediatric patients <5 years old with congenital deafness at a tertiary North American center. The inclusion criterion was pre- or […]
The Persistence of Tinnitus after Acoustic Neuroma Surgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Objective Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects and Methods The records of 166 patients who underwent acoustic neuroma resection from 2009 to 2014 were reviewed. Patients were asked to complete a survey, including the Tinnitus […]
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Objectives (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. Study Design Retrospective cohort study. Setting Tertiary care. Subjects and Methods Gene expression barcode analysis was applied to an existing publicly available data set of 54 […]
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Objective Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and to identify primary tumor characteristics that may predict parotid […]
Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Objective To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. Study Design Case series with chart review. Setting Tertiary referral academic center. Subjects and Methods Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed […]
Pluronic micelles for enhanced DOX and PTX delivery to brain glioma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Huang YK, Liu WC, Gao F, Fang XL, Chen YZ from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Vilzuh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1qYgWsr via IFTTT
Four novel ATP2C1 mutations in Chinese patients with Hailey–Hailey disease
Abstract Hailey–Hailey disease (HHD) is a kind of autosomal dominant dermatosis. The *ATP2C1* gene has been identified as the pathogenic gene of HHD since 2000. In this study, direct DNA sequencing was used to identify *ATP2C1* gene mutations in four Chinese families and two sporadic cases with HHD. The entire coding and flanking intronic sequences of *ATP2C1* were screened for mutations and five heterozygous mutations of the *ATP2C1* gene were detected in the four pedigrees and two sporadic cases with HHD. Four of them were novel, including three frame-shift mutations (c.1330delC,...περισσότερα »
Single, blue nevus-like localized argyria
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1qYgWc5 via IFTTT
Eccrine squamous syringometaplasia in sites of radiation recall secondary to vemurafenib therapy for BRAF-mutated carcinoma
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/20W352a via IFTTT
Gut Microbiota of Nonalcoholic Fatty Liver Disease
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 50 δευτερόλεπτα
Abstract The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microb... περισσότερα »
Articular surface segmentation using active shape models for intraoperative implant assessment
Abstract Purpose In orthopedic surgeries, it is important to avoid intra-articular implant placements, which increase revision rates and the risk of arthritis. In order to support the intraoperative assessment and correction of surgical implants, we present an automatic detection approach using cone-beam computed tomography (CBCT). Methods Multiple active shape models (ASM) with specified articular surface regions are used to isolate the joint spaces. Fast and easy-to-implement methods are integrated in the ASM segmentation to optimize the robustness and accuracy for intraoperati... περισσότερα »
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
There are no approved Food and Drug Administration indications for pediatric auditory brainstem implant (ABI) surgery in the United States. Our prospective case series aims to determine the safety and feasibility of ABI surgery in pediatric patients <5 years old with congenital deafness at a tertiary North American center. The inclusion criterion was pre- or […]
The Persistence of Tinnitus after Acoustic Neuroma Surgery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objective Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects and Methods The records of 166 patients who underwent acoustic neuroma resection from 2009 to 2014 were reviewed. Patients were asked to complete a survey, including the Tinnitus […]
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objectives (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. Study Design Retrospective cohort study. Setting Tertiary care. Subjects and Methods Gene expression barcode analysis was applied to an existing publicly available data set of 54 […]
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objective Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and to identify primary tumor characteristics that may predict parotid […]
Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objective To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. Study Design Case series with chart review. Setting Tertiary referral academic center. Subjects and Methods Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed […]
Pluronic micelles for enhanced DOX and PTX delivery to brain glioma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Huang YK, Liu WC, Gao F, Fang XL, Chen YZ from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Vilzuh via IFTTT
Effective management of patients with acute ischemic stroke based on lean production on thrombolytic flow optimization
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Abstract The efficacy of thrombolytic therapy for acute ischemic stroke (AIS) decreases when the administration of tissue plasminogen activator (tPA) is delayed. Derived from Toyota Production System, lean production aims to create top-quality products with high-efficiency procedures, a concept that easily applies to emergency medicine. In this study, we aimed to determine whether applying lean […]
The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Abstract Background Adults with moderate-to-severe primary restless legs syndrome (RLS) often experience painful dysesthesias, which may lead to impaired quality of life. Objectives The aim of this study was to assess the effects of gabapentin enacarbil (GEn) on pain associated with moderate-to-severe primary RLS in adults. Methods Data were pooled from three double-blind, randomized, placebo-controlled, […]
Clinical relevance of conus medullaris and dural sac termination level with special reference to sacral hiatus apex: anatomical and MRI radiologic study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Abstract The aim of this study was to determine the vertebral level and variations in the position of the termination of both conus medullaris (CMT) and dural sac (DST) with special reference to the apex of the sacral hiatus (SHA) using magnetic resonance (MR) images and human cadavers. Different measurements were made on 200 MR […]
Handwriting Impairments in People With Parkinsons Disease and Freezing of Gait
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
*Background.* Recent studies show that patients with Parkinson's disease (PD) and freezing of gait (FOG) experience motor problems outside their gait freezing episodes. Because handwriting is also a sequential movement, it may be affected in PD patients with FOG relative to those without. *Objective.* The current study aimed to assess the quality of writing in PD patients with and without FOG in comparison to healthy controls (CTs) during various writing tasks. *Methods.* Handwriting was assessed by the writing of cursive loops on a touch-sensitive writing tablet and by means of t... περισσότερα »
Informatıon given by multımedıa: influence on anxıety about extractıon of impacted wısdom teeth
Dental fear is the fourth most common fear among the population. Well-informed patients seemed to be less anxious, and have the least anxiety before a planned procedure. Our aim was to find out the ideal way of information required by the patient before extraction of an impacted wisdom tooth. A total of 129 patients listed… Continue reading Informatıon given by multımedıa: influence on anxıety about extractıon of impacted wısdom teeth
Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology
Andrea I. Loewendorf, Anna Matynia, Hakob Saribekyan, Noah Gross, Marie Csete, Mike Harrington (Source: Frontiers in Immunology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Ssip3x via IFTTT
Regulatory Role of IL-1R8 in Immunity and Disease
Martina Molgora, Isabella Barajon, Alberto Mantovani, Cecilia Garlanda (Source: Frontiers in Immunology) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1S9RR8d via IFTTT
Infliximab is the new kid on the block in Kawasaki disease: a single-centre study over 8 years from North India.
Authors: Singh S, Sharma D, Suri D, Gupta A, Rawat A, Rohit MK Abstract This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. The study was carried out in the Paediatric Allergy-Immunology Unit, Advanced Paediatrics Centre,… Continue reading Infliximab is the new kid on the block in Kawasaki disease: a single-centre study over 8 years from North India.
Molecular comparison of Slc11a1 and Slc11a2 genes of swamp‐ and riverine‐type water buffaloes
This study analysed the genetic characteristic of Slc 11a and 11a2 in swamp‐type and riverine‐type water buffaloes to understand their immunological distinction. Characterization of Slc11a1 and Slc11a2 genes from swamp‐ and riverine‐type water buffaloes was carried out by molecular cloning, sequencing and phylogenetic analysis. The cloned cDNA of Slc11a1 and Slc11a2 contained an open reading… Continue reading Molecular comparison of Slc11a1 and Slc11a2 genes of swamp‐ and riverine‐type water buffaloes
The optimal immunosuppressive protocol for the portal vein infusion of PGE1 and methylprednisolone in pediatric liver transplantation for fulminant hepatic failure of unknown etiology
Abstract The outcome of LTx in pediatric patients with FHF of unknown etiology remains inferior to that of LTx in pediatric patients with cholestatic diseases. A higher incidence of steroid‐resistant severe rejection has been increasingly recognized among the responsible factors. We assessed the efficacy of the administration of steroids and PGE1 via PVI in the… Continue reading The optimal immunosuppressive protocol for the portal vein infusion of PGE1 and methylprednisolone in pediatric liver transplantation for fulminant hepatic failure of unknown etiology
β-glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid resistant TH2/TH17 responses
Fungi are potent immunomodulators and promote development of severe steroid-resistant asthma independent of their potential to act as allergens. Strategies targeting IL-17A may be beneficial for the subgroup of fungal-exposed steroid-resistant asthmatics. (Source: Journal of Allergy and Clinical Immunology) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1S9RQB2 via IFTTT
Tumor-necrosis factor is a master of T cell exhaustion
Nature Immunology 17, 476 (2016). doi:10.1038/ni.3436 Authors: Amy E Baxter & Daniel E Kaufmann Chronic viral infections are characterized by ongoing inflammation and a dysfunctional T cell response, which results in a failure of the host to clear the pathogen. Now these two hallmarks of infection have been linked by the classic pro-inflammatory cytokine tumor-necrosis… Continue reading Tumor-necrosis factor is a master of T cell exhaustion
Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity
In this study, we first report the identification and characterization of the secreted Ly2.1-3 proteins on the chromosome 2 in zebrafish and determine the expression pattern. Ly2.1-3 all possess a conserved LU domain and adopt similar three-finger structure with human CD59, SLURP1 and other Ly6 family members. Ly2.1-3 cluster on chromosome 2 and share high… Continue reading Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity
Club cells to the rescue
Nature Immunology 17, 480 (2016). doi:10.1038/ni.3451 Author: Zoltan Fehervari (Source: Nature Immunology) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1SsirrZ via IFTTT
A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients
Abstract Background Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese. This study aimed to compare symptom generation according to TRPV1 genotypes and the intake of spicy foods. Methods Consecutive functional dyspepsia (FD) patients who were evaluated at Konkuk University Medical Centre (Korea) and Keio University Hospital (Japan) were included. Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms (PAGI-SYM), patient assessment of ... περισσότερα »
UK guideline for the use of HIV Post-Exposure Prophylaxis Following Sexual Exposure, 2015
We present the updated British Association for Sexual Health and HIV guidelines for HIV post-exposure prophylaxis following sexual exposure (PEPSE). This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE should and… Continue reading UK guideline for the use of HIV Post-Exposure Prophylaxis Following Sexual Exposure, 2015
Subpopulation Treatment Effect Pattern Plot (STEPP) analysis for continuous, binary, and count outcomes
Background: For the past few decades, randomized clinical trials have provided evidence for effective treatments by comparing several competing therapies. Their successes have led to numerous new therapies to combat many diseases. However, since their conclusions are based on the entire cohort in the trial, the treatment recommendation is for everyone, and may not be… Continue reading Subpopulation Treatment Effect Pattern Plot (STEPP) analysis for continuous, binary, and count outcomes
Generalized estimating equations in cluster randomized trials with a small number of clusters: Review of practice and simulation study
Background/aims: Generalized estimating equations are a common modeling approach used in cluster randomized trials to account for within-cluster correlation. It is well known that the sandwich variance estimator is biased when the number of clusters is small (≤40), resulting in an inflated type I error rate. Various bias correction methods have been proposed in the… Continue reading Generalized estimating equations in cluster randomized trials with a small number of clusters: Review of practice and simulation study
Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students
Background/aims: Recruitment of subjects is critical to the success of any clinical trial, but achieving this goal can be a challenging endeavor. Volunteer nurse and student enrollers are potentially an important source of recruiters for hospital-based trials; however, little is known of either the efficacy or cost of these types of enrollers. We assessed volunteer… Continue reading Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students
Fibrosis Assessment in Nonalcoholic Fatty Liver Disease (NAFLD) in 2016
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver pathologies characterized by hepatic steatosis with a history of little to no alcohol consumption or secondary causes of hepatic steatosis. The prevalence of NAFLD is 20–25 % of the general population in the Western countries and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipidemia. The spectrum of disease ranges from simple steatosis to nonalcoholic steatohepatitis, fibrosis, and cirrhosis. Advanced fibrosis is the most significant predictor of mortality in NAFLD. It ... περισσότερα »
Role of nucleotide excision repair proteins in response to DNA damage induced by topoisomerase II inhibitors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Publication date: Available online 19 April 2016 *Source:*Mutation Research/Reviews in Mutation Research Author(s): Jaqueline C. Rocha, Franciele F. Busatto, Temenouga N. Guecheva, Jenifer Saffi In cancer treatment, chemotherapy is one of the main strategies used. The knowledge of the cellular and molecular characteristics of tumors allows the use of more specific drugs, making the removal of tumors more efficient. Among the drugs of choice in these treatments, topoisomerase inhibitors are widely used against different types of tumors. Topoisomerases are enzymes responsible for main...περισσότερα »
Florida father-of-two kills his entire family in murder-suicide
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
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Novel Pharmacotherapy Options for NASH
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract While simple to recommend, diet and lifestyle measures as a first-line therapy for nonalcoholic steatohepatitis (NASH) are hardly a model of successful therapy, as most clinicians can testify. They can be complex to implement, hard to sustain, and of limited efficacy in advanced stages of the disease. The need for specific pharmacotherapy is now acknowledged by practitioners, the pharmaceutical industry, and regulators and is largely expected by patients. The result is a clear move away from products developed second hand for NASH (such as pioglitazone or metformin) or fro...περισσότερα »
Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome predicted to be the next global epidemic affecting millions of people worldwide. The natural course of this disease including its subtype, non-alcoholic steatohepatitis (NASH), is not clearly defined especially in the African-American segment of the US population. Aims To conduct a review of the global epidemiology of NAFLD with emphasis on US minority populations. Methods A thorough search of evidence-based literature was conducted using the Pubmed database and commercial web sources such as Me...περισσότερα »
Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common etiology of chronic liver disease in developed countries and is on trajectory to become the leading indication for liver transplantation in the USA and much of the world. Patients with NAFLD cirrhosis awaiting liver transplant face unique challenges and increased risk for waiting list stagnation and dropout due to burdensome comorbidities including obesity, diabetes, cardiovascular disease, and kidney disease. Thus far, patients transplanted for NAFLD cirrhosis have excellent mid- and long-term patient and graft s... περισσότερα »
Parathyroid carcinoma
[image: image]Purpose of review: This article highlights recent advances in our understanding of the incidence, epidemiology, clinical presentation, evaluation, diagnosis, treatment, and prognosis of parathyroid carcinoma. Recent findings: The prevalence of parathyroid carcinoma is approximately 0.005% of all cancers. Therefore, parathyroid carcinoma is one of the rarest malignancies known. Patients with parathyroid carcinoma present with clinical symptoms of hypercalcaemia as these cancers are usually hormonally functional. It is not uncommon that patients present with complications... περισσότερα »
PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
• Combining the PLAG control of exaggerated neutrophil extravasation with pegfilgrastim-induced production of neutrophils had a greater therapeutic effect on chemotherapy-induced neutropenia than pegfilgrastim alone.• The group treated with PLAG experienced dramatically increased neutrophil counts on the third day following pegfilgrastim treatment and PLAG had no effect on blood cell apoptosis and neutrophil release from […]
Thyrogen Co-Pay Assistance Program is available to support patient access to Thyrogen.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Thyrogen Co-Pay Assistance Program is available to support patient access to Thyrogen. This program helps with out-of-pocket costs that exceed $100 for eligible patients with… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rhopTX via IFTTT
In response to: A Pilot Study Investigating Basic Fibroblast Growth Factor for the Repair of Chronic Tympanic Membrane Perforations in Pediatric Patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
We would like to address the manuscript titled “A Pilot Study Investigating Basic Fibroblast Growth Factor for the Repair of Chronic Tympanic Membrane Perforations in Pediatric Patients” by Jellinge et al.1 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VCNkO3 via IFTTT
Response of Antarctic cryoconite microbial communities to light
Microbial communities on polar glacier surfaces are found dispersed on the ice surface, or concentrated in cryoconite holes and cryolakes, which are accumulations of debris covered by a layer of ice for some or all of the year. The ice lid limits the penetration of photosynthetically available radiation (PAR) to the sediment layer, since the ice attenuates up to 99% of incoming radiation. This suite of field and laboratory experiments demonstrates that PAR is an important control on primary production in cryoconite and cryolake ecosystems. Increased light intensity increased effic... περισσότερα »
Endoscopic ultrasound of the larynx
[image: image]Purpose of review: Endoscopic ultrasound (EUS) of the larynx is a vertical endoscopic imaging technique that gives further information about the extension of a lesion apart from normal white light endoscopy, chromoendoscopy, as well as palpation. It combines the advantages of ultrasound and endoscopy. Miniprobes or ultrasound endoscopes with 10–20 MHz are applied. The present review is focused on the use of EUS in the larynx especially in the management of laryngeal cancer. Recent findings: At present, the larynx is routinely assessed by computed tomography and MRI. Al... περισσότερα »
Reasonable limits for transoral laser microsurgery in laryngeal cancer
[image: image]Purpose of review: Transoral laser microsurgery (TLM) is widely acknowledged to offer several advantages in the treatment of early and selected intermediate-advanced laryngeal cancers. Nevertheless, a number of issues are still under debate. The purpose of this review is to discuss the reasonable limits for TLM in laryngeal cancer to highlight its most appropriate and reproducible indications, putting this therapeutic tool in the right perspective within a comprehensive frame of alternative treatment strategies such as open partial laryngectomies and nonsurgical organ ... περισσότερα »
Editorial introductions
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1pfD8gm via IFTTT
Ameloblastomas of the mandible and maxilla
Purpose of review: This review focuses on issues in managing ameloblastomas of the mandible and maxilla. We will refer to current practice in the treatment of ameloblastomas based on the available evidence. Recent findings: Recent reviews have been trying to establish natural history, growth patterns and malignant potential. This provides the clinicians and the patients… Continue reading Ameloblastomas of the mandible and maxilla
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices
Purpose of review: This article critically analyzes the recent literature on microvascular head and neck reconstruction after (chemo)radiation [(C)RT], taking into consideration both the underlying pathogenetic mechanisms and their clinical consequences. Recent findings: Microvascular reconstruction has gradually become a mainstay in the management of head and neck cancer both in primary and salvage scenarios. However,… Continue reading Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices
Reasonable limits for transoral laser microsurgery in laryngeal cancer
Purpose of review: Transoral laser microsurgery (TLM) is widely acknowledged to offer several advantages in the treatment of early and selected intermediate-advanced laryngeal cancers. Nevertheless, a number of issues are still under debate. The purpose of this review is to discuss the reasonable limits for TLM in laryngeal cancer to highlight its most appropriate and… Continue reading Reasonable limits for transoral laser microsurgery in laryngeal cancer
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices
Purpose of review: In this manuscript, we will provide a panorama of the current status of skull base reconstruction following endoscopic endonasal or open resection of malignant lesions, focusing on novel options and recent modifications of previously described techniques. Recent findings: New developments in skull base reconstruction continue to arise, mostly as in the form… Continue reading Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?
Purpose of review: Radiotherapy is one of the most effective treatment modalities for head and neck cancer. However, because of the intricacy between tumors and normal tissues, it can induce morbidity, such as mucositis, dermatitis, xerostomia, dysphagia, hearing loss, vision impairment, skin fibrosis, and osteoradionecrosis of the jaw, and it can dramatically impact on patient… Continue reading How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?
Midface prosthetic rehabilitation
Purpose of review: Midfacial defects resulting from head and neck oncological resections can be addressed by microvascular reconstructive techniques using autologous tissue. In specific indications, however, prosthetic rehabilitation can give a superior aesthetic outcome, combined with a less intensive surgical strain on the patient. In other situations, the combination of both approaches can restore much… Continue reading Midface prosthetic rehabilitation
Endoscopic ultrasound of the larynx
Purpose of review: Endoscopic ultrasound (EUS) of the larynx is a vertical endoscopic imaging technique that gives further information about the extension of a lesion apart from normal white light endoscopy, chromoendoscopy, as well as palpation. It combines the advantages of ultrasound and endoscopy. Miniprobes or ultrasound endoscopes with 10–20 MHz are applied. The present review… Continue reading Endoscopic ultrasound of the larynx
Early detection of oral cancers: current status and future prospects
Purpose of review: This article reviews the current literature and summarizes the latest developments in screening and early detection of oral cancers and looks at the future possibilities. Recent findings: Oral cancer is the best model for screening and prevention. The screening for oral cancer can be population based, opportunistic, or targeted. A long-term 15-year… Continue reading Early detection of oral cancers: current status and future prospects
Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity?
Purpose of review: Laryngeal cancer published literature was reviewed, with emphasis on reporting on young patients ( from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1S9Gmh3 via IFTTT
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