Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Factor X deficiency (FXD) is a rare bleeding disorder, which can result in severe bleeding symptoms such as intracranial hemorrhage (ICH). The most common bleeding symptoms are epistaxis and gum bleeding. ICH is reported in 9–26% of all patients with FXD, mostly during the first month of life. Here, we present a rare case of… Continue reading Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature
Dosimetric comparison between the prostate intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans using the planning target volume (PTV) dosevolume factor
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Research Articles James C. L. Chow, Runqing Jiang, Alexander Kiciak, Daniel Markel Journal of Radiotherapy in Practice,FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20ZPSFM via IFTTT
Simplified material assignment for cone beam computed tomography-based dose calculations of prostate radiotherapy with hip prostheses
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Research Articles Turki Almatani, Richard P. Hugtenburg, Ryan Lewis, Susan Barley, Mark Edwards Journal of Radiotherapy in Practice,FirstView Article(s), 11 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rnUNEw via IFTTT
Autoantibodies in Neuropsychiatric Disorders
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Little is known about the etiology of neuropsychiatric disorders. The identification of autoantibodies targeting the N-methyl-d-aspartate receptor (NMDA-R), which causes neurological and psychiatric symptoms, has reinvigorated the hypothesis that other patient subgroups may also suffer from an underlying autoimmune condition. In recent years, a wide range of neuropsychiatric diseases and autoantibodies targeting ion-channels or neuronal… Continue reading Antibodies Vol. 5 Pages 9: Autoantibodies in Neuropsychiatric Disorders
Impact of Gleason pattern 5 including tertiary pattern 5 on outcomes of salvage treatment for biochemical recurrence in pT2-3N0M0 prostate cancer
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Conclusions The presence of GP5 is an independent predictor of poor prognosis in patients with pT2-3N0M0 PC undergoing salvage treatment for BCR after radical prostatectomy. GP5 may thus be a more useful marker than conventional Gleason score in this setting. (Source: International Journal of Clinical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20ZPU0b via IFTTT
Should we include SPECT lung perfusion in radiotherapy treatment plans of thoracic targets? Evidences from the literature
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
(Source: Critical Reviews in Oncology Hematology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rnUJVj via IFTTT
Proposed radiological criteria for pre-operative determination of resectability in peritoneal-based malignancies
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 δευτερόλεπτα
Abstract Background The selection of patients for cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy infusion (HIPEC) is important, and relies heavily on imaging. However, it has been reported that Computer Tomographic (CT) scans may only achieve a low sensitivity of 33% for peritoneal disease. We propose a set of radiological criteria for pre-operative determination of… Continue reading Proposed radiological criteria for pre-operative determination of resectability in peritoneal-based malignancies
Laparoscopy-Assisted Proximal Gastrectomy with the Hinged Double Flap Method.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 δευτερόλεπτα
*Laparoscopy-Assisted Proximal Gastrectomy with the Hinged Double Flap Method.* World J Surg. 2016 Apr 19; Authors: Muraoka A, Kobayashi M, Kokudo Y Abstract BACKGROUND: No standard proximal gastrectomy method for gastric cancer of the upper third of the stomach (UGC) has been established because few of the current methods prevent gastro-esophageal reflux and allow easy postoperative endoscopic surveillance. In the present study, we describe laparoscopic proximal gastrectomy with the hinged double flap method (Kamikawa's method) in detail and examine the short- to medium-term ou... περισσότερα »
Sentinel node biopsy during thoracolaparoscopic esophagectomy for advanced esophageal cancer.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 δευτερόλεπτα
*Sentinel node biopsy during thoracolaparoscopic esophagectomy for advanced esophageal cancer.* World J Surg Oncol. 2016;14(1):117 Authors: Boone J, Hobbelink MG, Schipper ME, Vleggaar FP, Borel Rinkes IH, de Haas RJ, Ruurda JP, van Hillegersberg R Abstract BACKGROUND: Omitting extensive lymph node dissection could reduce esophagectomy morbidity in patients without lymph node metastases. Sentinel node biopsy may identify abdominal or thoracic lymph node metastases, thereby differentiating treatment. Feasibility of this approach was investigated in Western European esophageal canc... περισσότερα »
Radiofrequency Ablation Versus Endoscopic Submucosal Dissection in Treating Large Early Esophageal Squamous Cell Neoplasia.
Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Radiofrequency Ablation Versus Endoscopic Submucosal Dissection in Treating Large Early Esophageal Squamous Cell Neoplasia.* Medicine (Baltimore). 2015 Dec;94(49):e2240 Authors: Wang WL, Chang IW, Chen CC, Chang CY, Mo LR, Lin JT, Wang HP, Lee CT Abstract Radiofrequency ablation (RFA) and endoscopic submucosal dissection (ESD) can potentially be applied for early esophageal squamous cell neoplasia (ESCN); however, no study has directly compared these 2 modalities.We retrospectively enrolled the patients with flat... περισσότερα »
Induction infliximab levels among patients with acute severe ulcerative colitis compared with patients with moderately severe ulcerative colitis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
Alimentary Pharmacology and Therapeutics from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WHcIli via IFTTT
Incidence of hepatocellular carcinoma in untreated subjects with chronic hepatitis B: a systematic review and meta-analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
Liver International from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Svjl7d via IFTTT
Improvement of constipation in leukemia patients undergoing chemotherapy using sweet potato
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
Cancer Nursing from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WHcLgV via IFTTT
Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
International Journal of Colorectal Disease from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Svjl70 via IFTTT
Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
International Journal of Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WHcL0r via IFTTT
The Long-Term Prognosis of Voice Pitch Change in Female Patients After Thyroid Surgery.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα
*The Long-Term Prognosis of Voice Pitch Change in Female Patients After Thyroid Surgery.* World J Surg. 2016 Apr 19; Authors: Park JO, Bae JS, Lee SH, Shim MR, Hwang YS, Joo YH, Park YH, Sun DI Abstract BACKGROUND: Relatively large numbers of patients complain of lower-pitched voices after thyroidectomy. However, little is known about the risk factors for, prognosis of, or progression over time of, such changes, in female patients. METHODS: We analyzed the data of 217 patients who underwent thyroid surgery and postoperative (2 weeks, and 3, 6, and 12 months after surgery) voice w...περισσότερα »
Response to Treatment is Highly Predictable in cN0 Patients with Papillary Thyroid Carcinoma.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα
*Response to Treatment is Highly Predictable in cN0 Patients with Papillary Thyroid Carcinoma.* World J Surg. 2016 Apr 19; Authors: Gorshtein A, Benbassat C, Robenshtok E, Shimon I, Hirsch D Abstract BACKGROUND: While involvement of macrometastatic lymph nodes is a recognized independent predictor of an adverse course in papillary thyroid cancer (PTC) patients, the clinicopathological variables associated with disease persistence/recurrence in clinically node-negative (cN0) disease are not well defined. The indications for prophylactic central neck dissection (pCND) in this patie... περισσότερα »
Artificial Nerve Conduit Vascularization on Peripheral Nerve in a Necrotic Bed
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Effect of [image: image]Background: Several types of artificial nerve conduit have been used for bridging peripheral nerve gaps as an alternative to autologous nerves. However, their efficacy in repairing nerve injuries accompanied by surrounding tissue damage remains unclear. We fabricated a novel nerve conduit vascularized by superficial inferior epigastric (SIE) vessels and evaluated whether it could promote axonal regeneration in a necrotic bed. Methods: A 15-mm nerve conduit was implanted beneath the SIE vessels in the groin of a rat to supply it with blood vessels 2 weeks ... περισσότερα »
Orbital Inflammatory Diseases
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Clinical Features and Treatment Outcomes of Orbital Inflammatory Disease in Singapore: A 10-Year Clinicopathologic Review.: Purpose: 1) To assess the clinical profile and treatment outcomes of orbital inflammatory disease in the local population, and 2) classify patients using current histopathological criteria. Methods: Ten-year retrospective clinicopathologic review of patients diagnosed with orbital inflammatory disease who underwent tissue biopsy from January 2001 to December 2011 at a tertiary referral centre in Singapore. Data collection included patient demographics, clinical...περισσότερα »
Reversible Blindness Following Orbital Fracture Repair.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Reversible Blindness Following Orbital Fracture Repair.: The authors report a case of a 72-year-old woman with unilateral, complete, reversible blindness (no light perception) immediately after uncomplicated repair of an orbital floor fracture. In this case, vision loss was reversed with prompt surgical intervention with removal of the orbital floor implant. The authors review the etiology of vision loss after orbital fracture repair and hypothesize as to the cause of blindness in this case. Given the frequency with which orbital fracture repair is performed by a variety of surgical... περισσότερα »
Thyroid-Related Orbital Decompression Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
A Multivariate Analysis of Risk Factors and Outcomes.: Purpose: Despite the number of publications on orbital decompression surgery for thyroid eye disease, there are few comparative studies and most studies are underpowered. The goal of the study is to use multivariable analysis to identify independent patient and disease-related predictors of response to decompression surgery and of need for secondary decompressions. Methods: The authors retrospectively reviewed all patients who underwent transorbital thyroid-related orbital decompression surgery at the Kellogg Eye Center of the ...περισσότερα »
Congenital Sebaceous Trichofolliculoma of the Upper Eyelid.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Congenital Sebaceous Trichofolliculoma of the Upper Eyelid.: A 6-year-old male presented with a protruding hair emerging from a temporally located nodule on his left upper eyelid 5mm above the eyelid margin since birth. The lesion was excised and sent to histopathology. The features were consistent with congenital sebaceous trichofolliculoma, a rare hamartomatous skin lesion. (C) 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.
Thyroid eye disease,IgG4-related disease,sarcoidosis,vasculitis,Sjogren syndrome,giant cell arteritis,and myasthenia gravis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Laboratory Investigations for Diagnosis of Autoimmune and Inflammatory Periocular Disease: Part I.: Purpose: To review the important laboratory serological investigations routinely performed for the diagnosis of autoimmune and inflammatory diseases of the orbit and ocular adnexa. Methods: Review of the literature as well as personal clinical experience of the authors. Results: Periocular inflammation is a blanket term which refers to a wide variety of conditions affecting the orbit and the ocular adnexa. Although the etiology of each of these conditions is different, their similarit... περισσότερα »
Autoimmune and Inflammatory Periocular Disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Laboratory Investigations for Diagnosis of Autoimmune and Inflammatory Periocular Disease: Part I.: Purpose: To review the important laboratory serological investigations routinely performed for the diagnosis of autoimmune and inflammatory diseases of the orbit and ocular adnexa. Methods: Review of the literature as well as personal clinical experience of the authors. Results: Periocular inflammation is a blanket term which refers to a wide variety of conditions affecting the orbit and the ocular adnexa. Although the etiology of each of these conditions is different, their similarit... περισσότερα »
[Expression and clinical significance of MTDH HIF-1α and TKTL1 in laryngeal carcinoma].
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
*[Expression and clinical significance of MTDH, HIF-1α and TKTL1 in laryngeal carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2133-8 Authors: Jia X, Shan C, Xu O, Wang J Abstract OBJECTIVE: To investigate the functional mechanism of metadherin (MTDH), hypoxia-inducible factor-1 alpha (HIF-1α) and transketolase-like gene 1 (TKTL1) and their interaction with each other in laryngeal carcinoma development. METHOD: Thirty laryngeal carcinoma samples and 20 samples of para-carcinoma tissue were taken from the patients received operation treatment. The expre...περισσότερα »
In Vivo Antineoplastic Effects of the NSAID Sulindac in an Oral Carcinogenesis Model.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *In Vivo Antineoplastic Effects of the NSAID Sulindac in an Oral Carcinogenesis Model.* Cancer Prev Res (Phila). 2015 Jul;8(7):642-9 Authors: Katoumas K, Nikitakis N, Perrea D, Dontas I, Sklavounou A Abstract The antineoplastic properties of the NSAID sulindac have long been studied. The purpose of this study was to explore sulindac's in vivo effects on oral squamous cell carcinoma (SCC) oncogenesis using the hamster cheek pouch oral carcinogenesis model (HOCM). Thirty Syrian golden hamsters were divided into thre... περισσότερα »
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
*Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Yang SF, Bier-Laning CM, Adams W, Zilliox MJ Abstract OBJECTIVES: (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary care. SUBJECTS AND METHODS: Gene expression barcode analysis was applied to an existing publicly... περισσότερα »
Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.* Acta Otolaryngol. 2016 Apr 20;:1-4 Authors: Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S Abstract BACKGROUND: A standard chemotherapy for recurrent/metastatic salivary gland cancers has not been established. Combination chemotherapy of carboplatin and paclitaxel should be evaluated as a treatment option. METHODS: This study retrospectively reviewed sal... περισσότερα »
macrophage; 34 new citations
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
34 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/04/21 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1T17afI via IFTTT
[Advances in molecular targeted therapy of thyroid carcinoma].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Advances in molecular targeted therapy of thyroid carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2188-90 Authors: Feng H, Cheng X, Zeng F Abstract Thyroid carcinoma is the most common endocrine maligancy, and the worldwide incidence has been rising in recent years. Differentiated thyroid carcinoma is the most common thyroid malignancy, which include thyroid papillary carcinoma and follicular thyroid carcinoma, accounting for about 90 percent of thyroid carcinoma incidence. Currently, surgical treatment, iodine radiotherapy and TSH suppressive therap...περισσότερα »
[The etiology research progress of oculo-auriculo-vertebral spectrum].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The etiology research progress of oculo-auriculo-vertebral spectrum].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2184-8 Authors: Wang P, Fan Y, Chen X Abstract Oculo-auriculo-vertebral spectrum (OAVS), also known as Goldenhar syndrome, hemifacial microsomia, oculo-auriculo-vertebral dysplasia and facio-auriculo-vertebral spectrum, is a developmental disorder associated with the first and second branchial arches. Most cases are sporadic, while some familial instances observed suggested that the etiology of OAVS heterogeneous. In this review, we summarize the...περισσότερα »
[The progress of research about anatomy of posterolateral wall of maxillary sinus in endoscopic surgery].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The progress of research about anatomy of posterolateral wall of maxillary sinus in endoscopic surgery].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2181-4 Authors: Gao L, Huang X Abstract As an important landmark, the posterolateral wall of maxillary sinus can help to locate numbers of significant signs such as maxillary artery and its branches, maxillary nerve and infraorbital nerve, infratemporal fossa and pterygopalatine fossa etc. in the endoscopic surgery for paranasal sinuses and lateral skull base. This article reviewed related researches about the ... περισσότερα »
[Right non recurrent laryngeal nerve during thyroid surgery: one case report].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Right non recurrent laryngeal nerve during thyroid surgery: one case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2179-80 Authors: Huang W, Zhang Q, She C Abstract A 56 years old female was admitted to our department with complaint of a painless cervical mass. Clinical feature:there was a painless mass above left lobe of thyroid gland, which was about 3.0 cm x 2.5 cm in size, and could move with swallowing action. B-mode ultrasound features: there was a solid mass in left lobe of thyroid gland, which was about 3.2 cm. Nodule was found in isthmus, ac... περισσότερα »
[Langerhans cell histiocytosis in children with nasal congestion as chief complain: a case report].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Langerhans cell histiocytosis in children with nasal congestion as chief complain: a case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2177-9 Authors: Zhang Y, Chen W, Li Y Abstract Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder. Here, we report a rare case of multi-system LCH in a 20-month-old children presenting nasal congestion, fever, abnormal liver function, anemia, and skin damage. The radiograph computed tomography showed an osteolytic lesion in the lateral skull base with tumor extension. Pathological biopsy was performed...περισσότερα »
[The comparison of clinical features of 2 cases of intracranial otogenic complications].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The comparison of clinical features of 2 cases of intracranial otogenic complications].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2175-6 Authors: Yuan Y, Zhao X, Xiao D Abstract Two cases of special intracranial otogenic complications were analyzed in the aspects of clinical characteristics, diagnosis and therapy. We concluded that for patients with huge cholesteatoma which damaged the bone of skull base, or chronic otitis media patients with sharp deterioration in symptoms, accompanied by headache and fever, we should promptly do the enhanced magnetic re...περισσότερα »
[The treatment of pharyngeal and laryngeal hemangioma by injection with urea combined with pingyangmycin].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The treatment of pharyngeal and laryngeal hemangioma by injection with urea combined with pingyangmycin].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2172-4 Authors: Fan F, Zang Y, Jia X PMID: 27093823 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1pklKXO via IFTTT
[Application of linear stapler in total laryngectomy].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Application of linear stapler in total laryngectomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2170-2 Authors: Chen L, Qin Z, Qian Z PMID: 27093822 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1VHGQx7 via IFTTT
[Complications associated with silicone T-tube placement in the treatment of cicatricial subglottic and tracheal stenosis].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Complications associated with silicone T-tube placement in the treatment of cicatricial subglottic and tracheal stenosis].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2166-9 Authors: Hu T, Zhu X, Lei W PMID: 27093821 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1pklKqP via IFTTT
[Expression of human ether-a-go-go-related gene in laryngeal carcinoma].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Expression of human ether-a-go-go-related gene in laryngeal carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2160-3 Authors: Liang D, Wang L, Ji W Abstract OBJECTIVE: To study the expression of human ether-α-go-go-related gene (herg) and hERG protein expressed by the gene in laryngeal carcinoma compared with the control group(mucosa adjacent to cancer of 2 cm). METHOD: Expression of herg and hERG protein was detected by immunohistochemistry (SP) and real-time PCR in resected tissue of laryngeal carcinoma and mucosa adjacent to cancer of 2 cm. RESULT: (... περισσότερα »
[Endoscopic treatment of small osteoma of nasal sinuses manifested as nasal and facial pain].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Endoscopic treatment of small osteoma of nasal sinuses manifested as nasal and facial pain].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2157-9 Authors: Li Y, Zheng T, Li Z, Deng H, Guo C Abstract OBJECTIVE: To discuss the clinical features, diagnosis and endoscopic surgical intervention for small steoma of nasal sinuses causing nasal and facial pain. METHOD: A retrospective review was performed on 21 patients with nasal and facial pain caused by small osteoma of nasal sinuses, and nasal endoscopic surgery was included in the treatment of all cases. RESULT: ...περισσότερα »
[The treatment principles of frontal sinus tract after the frontal approach craniotomy].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The treatment principles of frontal sinus tract after the frontal approach craniotomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2154-6 Authors: Yu H, Li H, Liu G Abstract OBJECTIVE: To investigate the causes, clinical manifestation and treatment principles of frontal sinus tract after the frontal approach craniotomy. METHOD: The clinic data of 13 patients with frontal skin sinus tract after the frontal approach craniotomy were retrospectively analyzed. All of them were described in the clinical record to have undergone frontal sinus mucosa pushing down o... περισσότερα »
[Pacilitaxel induces human nasopharyngeal carcinoma cell line CNE2 apoptosis and growth inhibition by suppressing PI3K/AKT/p53 signaling pathway].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[Pacilitaxel induces human nasopharyngeal carcinoma cell line CNE2 apoptosis and growth inhibition by suppressing PI3K/AKT/p53 signaling pathway].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2147-50 Authors: Li T Abstract OBJECTIVE: To investigate the effect and mechanisms of the PTX on the human nasopharyngeal carcinoma cell line CNE2. METHOD: Cells from CNE2 were cultured in vitro and the cells at logarithmic growth phase were processed with different concentration of PTX (0, 5, 10, 20) mol/L for 72h. MTT was used to evaluate the proliferation and flow cyt...περισσότερα »
[The preparation of recombinant adenovirus Ad-Rad50-GFP and detection of the optimal multiplicity of infection in CNE1 transfected hv Ad-Rad50-GFP].
Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*[The preparation of recombinant adenovirus Ad-Rad50-GFP and detection of the optimal multiplicity of infection in CNE1 transfected hv Ad-Rad50-GFP].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2143-6 Authors: Yan R, Huang J, Zhu L, Chang L, Li J, Wu X, Ye J, Zhang G Abstract OBJECTIVE: The optimal multiplicity of infection (MOI) of the recombinant adenovirus Ad-Rad50-GFP carrying a mutant Rad50 gene expression region on the cell growth of nasopharyngeal carcinoma and the viral amplification efficiency of CNE1 cell infected by this adenovirus were studied. METH... περισσότερα »
The chin skin on autonomic nervous activities during propofol sedation with or without midazolam
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Comparison of the effect of electrical stimulations on via Oral and Maxillofacial Surgery Publication date: Available online 20 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Karin Sawaguchi, Nobuyuki Matsuura, Tatsuya Ichinohe PurposeThe aim of this study was to compare the effect of electrical stimulations on the chin skin on autonomic nervous activities evaluated by using power spectrum analysis of heart rate variability during intravenous sedation using propofol with or without midazolam.Patients and MethodsThirty-eight healthy adult male volunteers underw... περισσότερα »
Hypotensive anesthesia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
: Comparing the effects of different drug combinations on mean arterial pressure, estimated blood loss, and surgery time in orthognathic surgery via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 15 April 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): James Jeong, Jason E. Portnof, Mona Kalayeh, Patrick Hardigan Sevoflurane, an inhalational hypotensive anesthetic agent with a vasodilatory property, has been commonly used as a single agent to induce hypotension and effectively decrease blood loss in orthognathic surg... περισσότερα »
[Effects of simultaneous multi-level surgery intervention on the changes of the oxidative stress and the cognitive function in young and middle-aged patients with Moderate-severe obstructive sleep apnea hypopnea syndrome].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[Effects of simultaneous multi-level surgery intervention on the changes of the oxidative stress and the cognitive function in young and middle-aged patients with Moderate-severe obstructive sleep apnea hypopnea syndrome].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2139-42 Authors: Wang Q, Chen R, Cao Z, Yuan H, Zhao W, Li X, Wu X, Xin J, Liu Z, Li W Abstract OBJECTIVE: To explore the effects of simultaneous multi-level surgery intervention on the changes of the oxidative stress and the cognitive function in young and middle-aged patients with moderate-sever... περισσότερα »
[Expression and clinical significance of MTDH HIF-1α and TKTL1 in laryngeal carcinoma].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[Expression and clinical significance of MTDH, HIF-1α and TKTL1 in laryngeal carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2133-8 Authors: Jia X, Shan C, Xu O, Wang J Abstract OBJECTIVE: To investigate the functional mechanism of metadherin (MTDH), hypoxia-inducible factor-1 alpha (HIF-1α) and transketolase-like gene 1 (TKTL1) and their interaction with each other in laryngeal carcinoma development. METHOD: Thirty laryngeal carcinoma samples and 20 samples of para-carcinoma tissue were taken from the patients received operation treatment. The expre...περισσότερα »
Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Feinstein AJ, Alonso J, Yang SE, St John M Abstract OBJECTIVE: To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral academic center. SUBJECTS AND METHODS: Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed for 1076 pa... περισσότερα »
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Khandelwal AR, Ma X, Egan P, Kaskas NM, Moore-Medlin T, Caldito G, Abreo F, Gu X, Aubrey L, Milligan E, Nathan CO Abstract OBJECTIVE: Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and ...περισσότερα »
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Puram SV, Barber SR, Kozin ED, Shah P, Remenschneider A, Herrmann BS, Duhaime AC, Barker FG, Lee DJ Abstract There are no approved Food and Drug Administration indications for pediatric auditory brainstem implant (ABI) surgery in the United States. Our prospective case series aims to determine the safety and feasibility of ABI surgery in pediatric patients <5 years old with congenital deafness at a tertiary North Americ... περισσότερα »
The Persistence of Tinnitus after Acoustic Neuroma Surgery.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*The Persistence of Tinnitus after Acoustic Neuroma Surgery.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Bell JR, Anderson-Kim SJ, Low C, Leonetti JP Abstract OBJECTIVE: Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. STUDY DESIGN: Case series with chart review. SETTING: Tertiary academic medical center. SUBJECTS AND METHODS: The records of 166 patients who underwent acoustic neuroma resection from 2009 to 2014 were reviewed. Patients were asked to complete a survey, including the Tinnitus Handicap Inventory, 1 to 6 years ... περισσότερα »
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Yang SF, Bier-Laning CM, Adams W, Zilliox MJ Abstract OBJECTIVES: (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary care. SUBJECTS AND METHODS: Gene expression barcode analysis was applied to an existing publicly... περισσότερα »
Morphometric Differences of Vocal Tract Articulators in Different Loudness Conditions in Singing.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Morphometric Differences of Vocal Tract Articulators in Different Loudness Conditions in Singing.* PLoS One. 2016;11(4):e0153792 Authors: Echternach M, Burk F, Burdumy M, Traser L, Richter B Abstract INTRODUCTION: Dynamic MRI analysis of phonation has gathered interest in voice and speech physiology. However, there are limited data addressing the extent to which articulation is dependent on loudness. MATERIAL AND METHODS: 12 professional singer subjects of different voice classifications were analysed concerning the vocal tract profiles recorded with dynamic real-time MRI with 25... περισσότερα »
[A smoker with hoarseness and a swelling of his neck].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[A smoker with hoarseness and a swelling of his neck].* Ned Tijdschr Geneeskd. 2016;160(0):A9848 Authors: van der Poel NA, Vleming M, Bok JW Abstract A 68-year-old man was referred to the Department of Otolaryngology because of a swelling of his neck and hoarseness. CT imaging of his neck revealed a cystic mass in the larynx as well as in the neck, with an air-fluid level. The diagnosis 'laryngopyocele' was made. PMID: 27096477 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1r1ByQL via IFTTT
Diode Laser for Laryngeal Surgery: a Systematic Review.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Diode Laser for Laryngeal Surgery: a Systematic Review.* Int Arch Otorhinolaryngol. 2016 Apr;20(2):172-9 Authors: Arroyo HH, Neri L, Fussuma CY, Imamura R Abstract UNLABELLED: Introduction The diode laser has been frequently used in the management of laryngeal disorders. The portability and functional diversity of this tool make it a reasonable alternative to conventional lasers. However, whether diode laser has been applied in transoral laser microsurgery, the ideal parameters, outcomes, and adverse effects remain unclear. Objective The main objective of this systematic review i... περισσότερα »
Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.* Int Arch Otorhinolaryngol. 2016 Apr;20(2):151-5 Authors: Chiesa Estomba CM, Reinoso FA, Velasquez AO, Fernandez JL, Conde JL, Hidalgo CS Abstract Introduction Transoral laser microsurgery (TLM) has established itself as an effective option in the management of malignant tumors of the glottis, supraglottis, and hypopharynx. Nonetheless, TLM is not a harmless technique. Complications such as bleeding, dyspnea, or ignition of the air may appear in this type of surgery. Objective The aim of this study is to de... περισσότερα »
Facial paralysis induced by ear inoculation of herpes simplex virus in rat.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Facial paralysis induced by ear inoculation of herpes simplex virus in rat.* Auris Nasus Larynx. 2016 Apr 16; Authors: Fujiwara T, Matsuda S, Tanaka J, Hato N Abstract OBJECTIVE: Bell's palsy is caused by the reactivation of herpes simplex virus type 1 (HSV-1). Using Balb/c mice inoculated with the KOS strain of HSV-1, we previously developed an animal disease model that simulated mild Bell's palsy. The current study developed an animal disease model of more severe facial palsy than that seen in the mouse model. METHODS: Three-week-old female Wister rats weighing 60-80g were inoc...περισσότερα »
Evaluation of life quality self-confidence and sexual functions in patients with total and partial laryngectomy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Evaluation of life quality, self-confidence and sexual functions in patients with total and partial laryngectomy.* Auris Nasus Larynx. 2016 Apr 16; Authors: Batıoğlu-Karaaltın A, Binbay Z, Yiğit Ö, Dönmez Z Abstract OBJECTIVE: In this study patients who have undergone partial (PL) or total laryngectomy (TL) were evaluated for life quality, self-esteem and sexual dysfunctions. METHODS: 108 patients who received TL or PL without tracheostoma were included in this study. During patient interview, sociodemographical data form, European Organization for Research and Treatment of Cance...περισσότερα »
[One case of condyloma of pharynx and larynx].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[One case of condyloma of pharynx and larynx].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Apr 7;51(4):303-4 Authors: Yang CL, Tang HX PMID: 27095728 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1r1Bws2 via IFTTT
Implementation of a rapid learning platform: Predicting 2-year survival in laryngeal carcinoma patients in a clinical setting.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Implementation of a rapid learning platform: Predicting 2-year survival in laryngeal carcinoma patients in a clinical setting.* Oncotarget. 2016 Apr 15; Authors: Lustberg T, Bailey M, Thwaites DI, Miller A, Carolan M, Holloway L, Rios Velazquez E, Hoebers F, Dekker A Abstract Background and PurposeTo improve quality and personalization of oncology health care, decision aid tools are needed to advise physicians and patients. The aim of this work is to demonstrate the clinical relevance of a survival prediction model as a first step to multi institutional rapid learning and compar... περισσότερα »
Induction chemotherapy for head and neck cancer: is there still a role?
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*Induction chemotherapy for head and neck cancer: is there still a role?* Future Oncol. 2016 Apr 20; Authors: Ove R, Nabell LM Abstract Integration and optimization of active systemic agents and radiosensitizers into the therapeutic regimen for head and neck cancer remains a topic of active investigation. Recent trials have not consistently supported the use of induction chemotherapy. There are several clinical scenarios in which there is a strong rationale for induction chemotherapy, such as larynx preservation, unfavorable sites and bulky locally advanced disease. The increasin... περισσότερα »
[Variation of extralaryngeal furcation of the recurrent laryngeal nerve in total thyroidectomy].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[Variation of extralaryngeal furcation of the recurrent laryngeal nerve in total thyroidectomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2163-5 Authors: Fan Z, Zhang L, Zhang Y Abstract OBJECTIVE: To explore the extralaryngeal furcation variation of the recurrent laryngeal nerve (RLN) in total thyroidectomy. METHOD: The clinical data of 216 RLNs from 108 patients undergone total thyroidectomy were retrospectively analyzed. RESULT: RLN was found during every operation and exposed in whole course until access into larynx. Twenty (9.26%) pieces of RLNs showed...περισσότερα »
[Sentinel lymph node detection of rabbit tongue by indirect CT lymphography combined with nanocarbon tracer].
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
*[Sentinel lymph node detection of rabbit tongue by indirect CT lymphography combined with nanocarbon tracer].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2151-4 Authors: Yang Y, Shi F, Chen X, Huang W, Wu H Abstract OBJECTIVE: To investigate the value of indirect CT lymphography (CT-LG) combined with nanocarbon tracer suspension staining in the sentinel lymph node (SLN) detection of rabbit tongue (cancer). METHOD: Eight rabbits were divided into two groups, i. e. normal control group (6 rabbits) and VX2 tongue carcinoma group (2 rabbits). Pre-contrast CT imag...περισσότερα »
The Delta plate for surgical treatment of patients with condylar fractures
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Use of via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 15 April 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Maciej Sikora, Marcin Sielski, Agata Stąpor, Dariusz Chlubek PurposeThe purpose of this study was to summarize the results of our own experience in the application of the Delta plate for surgical treatment of condylar fractures.Material and MethodsThe research was carried out in 42 patients of the Department for Maxillofacial Surgery, Hospital of the Ministry of Interior in Kielce (Poland), who were su... περισσότερα »
Residual sialolith fragments after transoral approach of Wharton’s duct
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Evaluation of the prevalence of via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 15 April 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): M. Gerni, J.M. Foletti, C. Collet, C. Chossegros Transoral submandibular duct sialolith removal is a simple technique with very few complications. Nevertheless, following this procedure, we have observed long-term calculus recurrence in a number of patients. We therefore elected to evaluate these cases. This was a monocentric prospective study performed between November 2013 an... περισσότερα »
Malignant Transformation of Oral Submucous Fibrosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Oral submucous fibrosis : Review on mechanisms of malignant transformation via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Rasika Priyadharshani Ekanayaka, Wanninayake Mudiyanselage Tilakaratne Researches focusing on various aspects of carcinogenesis in the background of fibrosis have advanced significantly in the recent past allowing us to understand the mechanisms involved in malignant transformation of oral submucous fibrosis (OSF), th... περισσότερα »
Malignant Transformation of Oral Submucous Fibrosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
: Overview of Histopathological Aspects via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Jay Gopal Ray, Kannan Ranganathan, Amit Chattopadhyay Oral sub mucous fibrosis (OSF), first described in 1952 is a potentially malignant disorder associated with betel quid and areca nut chewing mostly in the population of Indian subcontinent and South East Asia. Malignant transformation of OSF to squamous cell carcinoma (SCC) has been estimated to be ... περισσότερα »
Oral Submucous Fibrosis Induced by Bleomycin
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
A Rat Model of via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Shan-Shan Zhang, Zhao-Jian Gong, Wei Xiong, Xiao Wang, Qian Min, Chong-Dai Luo, Tian-You Ling ObjectiveThe aim of this study was to induce a rat model of oral submucous fibrosis (OSF) using bleomycin.Study DesignA randomized trial was performed. Bleomycin dilution or phosphate-buffered saline were injected into the buccal mucosa of the test and control rats, respectively, dai...περισσότερα »
Oral Submucous Fibrosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
: A review of the current management and possible directions for novel therapies via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Saman Warnakulasuriya, A. Ross Kerr This literature review addressed the tried out interventions for the management of oral submucous fibrosis. The literature supports the use of several medical interventions, including micronutrients, anti-oxidants, proteolytic enzymes, immune modulators (mainly steroids), and ...περισσότερα »
HER2-positive Metastatic Salivary Adenocarcinoma, NOS Treated with Trastuzumab
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Sustained Response of via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 20 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Naseem Ghazali, Lynette Parker, Kathleen Settle, Joshua E. Lubek PurposeAdenocarcinoma, not otherwise specified (AD-NOS) is an aggressive salivary gland carcinoma subtype with poor prognosis. Her2/neu-targeted therapy may be beneficial in cases of over-expression (20% of AD-NOS). A case of metastatic AD-NOS of the submandibular gland showing sustained complete respons... περισσότερα »
Restricted mouth opening in oral submucous fibrosis : Intralesional corticosteroids
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Intralesional corticosteroids as a treatment for restricted mouth opening in oral submucous fibrosis via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): R.P. Ekanayaka, M.P.B. Herath, R.D. Jayasinghe, M.A.M. Sitheeque, H. Amarasinghe, W.M. Tilakaratne ObjectivesOral submucous fibrosis (OSF) is a chronic debilitating disease of oral mucosa, associated with an increased risk of malignancy. The primary objective of this study was to evaluate th...περισσότερα »
Oral submucous fibrosis (OSF)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
A historical perspective and a review on aetiology and pathogenesis via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Wanninayake Mudiyanselage Tilakaratne, Rasika Priyadharshani Ekanayaka, Saman Warnakulasuriya BackgroundOral submucous fibrosis (OSF) is a chronic, insidious disease characterized by progressive submucosal fibrosis of the oral cavity and the oropharynx. People affected by this disease mostly live in south Asia, but migrants ... περισσότερα »
Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
A Rare Pediatric Case Report: AbstractAneurysmal bone cyst (ABC) is an uncommon, non-neoplastic, expansive and erosive bone lesion. Considered as a pseudocyst due the lack of epithelial lining, the presence of giant cells and similarity to other lesions can make preoperative diagnosis difficult; biopsy findings must be co-related to complete clinical and radiological assessment. ABC’s controversial etiopathogenesis and variable clinicopathological presentations have been widely described, but to date, there are just a few reports in literature describing the development of fibrous ... περισσότερα »
Ropivacaine 0.75 % and Lignocaine 2 % with 1:200,000 Adrenaline.Ropivacaine is a safe, clinically acceptable long acting local anaesthetic agent with added advantage of effective diffusion property.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Comparison of Ropivacaine 0.75 % and Lignocaine 2 % with 1:200,000 Adrenaline in Dental Extractions: Single Blind Clinical Trial: Abstract IntroductionThe aim of this study was to evaluate the efficacy, safety and clinical acceptability of the local anaesthetic agent ropivacaine 0.75 % in comparison with lignocaine 2 % with adrenaline 1:200,000 in minor oral surgical procedures. MethodsForty-seven patients, who required bilateral extractions in a single arch, were included in this study. One hundred and sixty-six extractions were performed and all the patients were administered... περισσότερα »
Ocular Injuries in Patients of Zygomatico-Complex (ZMC) Fractures
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Ocular Injuries in Patients of Zygomatico-Complex (ZMC) Fractures: Abstract PurposeMid face injuries commonly destroy the integrity of the orbital skeleton, and are frequently complicated by injury to the eye, ranging between 2.7 and 90.6 % as reported in literature. The eye injuries range from simple subconjunctival haemorrhage to globe rupture. The paper aims to study the types of ocular injuries in patients with ZMC fractures. Patients and MethodsA study of 67 patients, who had sustained facial trauma sufficient to lead to a facial bone fracture, was undertaken in the depart... περισσότερα »
Thromboembolic Events During Dental Extractions
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Clinical Trial Evaluating the Risk of Abstract PurposeDiscontinuation of anti-platelet therapy increases the risk of thrombotic complications whereas its continuation is believed to increase the risk of prolonged post-extraction bleeding. We therefore, performed this study to evaluate the risk of significant bleeding following dental extractions and also to assess the necessity of discontinuing anti-platelet therapy. Patients and methodsThree hundred patients requiring dental extraction were included in the study in which 200 patients were on anti-platelet therapy. Patients we... περισσότερα »
An Alternative Approach in Patients with Bilateral Auricular Defects due to Chemical Assault
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Osseointegrated Implants Acid attacks committed as crimes of passion are unfortunately becoming far from infrequent occurrence. The injuries sustained in such attacks mainly involve the face and trunk, with the acid causing cutaneous and subcutaneous tissue burns that can result in permanent scarring, loss of the nose or external ear, and severe visual impairment. Different surgical solutions have been proposed for reconstruction of the auricle following loss of the ear through traumatic injury or cancer or in patients with congenital defects: surgical reconstruction may involve t... περισσότερα »
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Case Report and Review of the Literature: AbstractInterdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell car...περισσότερα »
Malignant Vagal Paraganglioma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Malignant Vagal Paraganglioma: AbstractParagangliomas are rare, typically benign neuroendocrine tumors that represent a small portion of head and neck tumors. A small percentage of these are known to have malignant potential. They arise from the carotid body, jugular bulb or vagus nerves. There is limited literature discussing the management of malignant vagal paragangliomas. We present a case of a 25 year old female with a left malignant vagal paraganglioma. The following case presentation will describe the presentation, classic radiologic findings, and management of a malignant v... περισσότερα »
Epithelioid Hemangioendothelioma of the Maxillary Sinus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Epithelioid Hemangioendothelioma of the Maxillary Sinus: AbstractThe clinical course and pathologic features of a 72 year old female who presented with epistaxis are presented. Radiographic findings were notable for a large, soft tissue lesion filling the maxillary sinus with significant bony erosion and expansion. The patient was ultimately diagnosed with epithelioid hemangioendothelioma (EHE) and underwent endoscopic resection. She has no evidence of local, regional or distant recurrence 14 months post-surgery. The rarity of this neoplasm, the unusual anatomic location and non-sp... περισσότερα »
Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node: AbstractHead and neck angiosarcoma is an infrequent malignant vascular tumor most commonly found in the skin and soft tissue of the head and neck. Most head and neck angiosarcomas are metastatic to cervical lymph nodes from other primitive location. We describe herein a case of primary high-grade poorly differentiated angiosarcoma arising in an intra-parotid lymph node, discuss the value of immunohistochemical stains for differential diagnosis, and review the literature concerning head and neck a...περισσότερα »
Patients with total and partial laryngectomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Article in Press Evaluation of life quality, self-confidence and sexual functions in patients with total and partial laryngectomy Ayşegül Batıoğlu-Karaaltıncorrespondenceemail, Zerrin Binbay, Özgür Yiğit, Zehra Dönmez DOI: http://dx.doi.org/10.1016/j.anl.2016.03.007 Abstract Objective In this study patients who have undergone partial (PL) or total laryngectomy (TL) were evaluated for life quality, self-esteem and sexual dysfunctions. Methods 108 patients who received TL or PL without tracheostoma were included in this study. During patient interview, sociodemographical data form, Eu...περισσότερα »
Change of nystagmus direction during a head-roll test in lateral semicircular canal cupulolithiasis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Article in Press Jung Eun Shin, Kyung-Hwa Jeong, Sung Hwan Ahn, Chang-Hee Kimcorrespondenceemail Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea DOI: http://dx.doi.org/10.1016/j.anl.2016.04.001 Abstract Objective To demonstrate positional nystagmus during a head-roll test in two patients with lateral semicircular canal (LSCC) cupulolithiasis who presented with spontaneous detachment of otoliths from the LSCC cupula, and to confirm that otoliths may adhere to both the utricle and ... περισσότερα »
Endoscopic approach for cochlear implantation in advanced otosclerosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Article in Press Daniele Marchioni, Davide Soloperto, Luca Bianconicorrespondenceemail, Maria C. Guarnaccia, Elisabetta Genovese, Livio Presutti DOI: http://dx.doi.org/10.1016/j.anl.2016.03.003 Abstract Hypothesis Ossification of the cochlea was once considered to be a contraindication for cochlear implantation. Advances in cochlear implant technology and coding strategies have led to developments in different surgical procedures to manage cochlear ossification. The endoscopic technique allows a direct approach to the round window and the cochlea, especially in remodeled labyrinth, a...περισσότερα »
Oral Cavity Clear Cell Odontogenic Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Oral Cavity Clear Cell Odontogenic Carcinoma: AbstractA case of clear cell odontogenic carcinoma of the oral cavity is described in this sine qua non radiology-pathology correlation article. CT demonstrated a solid and cystic mass arising from the mandible. Histology demonstrated variably-sized nests of clear to pale eosinophilic cells with occasional central necrosis embedded in a hyalinized to fibrocellular stroma. The specimen was also positive for the characteristic rearrangement of the EWSR1 (22q12) locus in 93.5 % of interphase cells.
Langerhans Cell Histiocytosis of the Temporal Bone
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Langerhans Cell Histiocytosis of the Temporal Bone: AbstractLangerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features ... περισσότερα »
Neuropsychological Assessment Following Concussion
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
an Evidence‐Based Review of the Role of Neuropsychological Assessment Pre- and Post-Concussion: AbstractNeuropsychological evaluation is one component of a comprehensive and multifaceted assessment following concussion. Although some neuropsychologists use a “hybrid” assessment approach integrating computerized neurocognitive testing batteries with traditional paper and pencil tests, computerized neurocognitive test batteries are the predominant testing modality for assessment of athletes from the youth to professional level. This review summarizes the most recent research suppor... περισσότερα »
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss: AbstractLoss of auditory sensory hair cells is the major pathological feature of noise-induced hearing loss (NIHL). Currently, no established clinical therapies for prevention or amelioration of NIHL are available. The absence of treatments is due to our lack of a comprehensive understanding of the molecular mechanisms underlying noise-induced damage. Our previous study indicates that epigenetic modification of histones alters hair cell survival. In this study, we investigated the effect of noise exposure on h... περισσότερα »
Hemostatic Materials and Devices
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Hemostatic Materials and Devices: Numerous absorbable substances have been introduced to aid hemostasis in sinus and skull base surgery. Within the confines of the sinus and nasal cavities, ideal hemostatic agents must have several qualities. They must provide hemostasis, conform to an irregular wound bed, and enable healing of the traumatized mucosa without additional detriment to the epithelium. Traditional nasal packing has been substituted largely by absorbable materials designed to improve patient comfort and outcomes. Although many promising agents exist, none have become stand...περισσότερα »
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma: The aim of this study was to investigate the clinical features and prognosis of patients with squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (IP). AbstractObjective The aim of this study was to investigate the clinical features and prognosis of patients with squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (IP). Methods The medical records of 95 patients who were diagnosed with IP or SCC associated with IP were retrospectively reviewed.... περισσότερα »
Platelet-rich-Plasma (PRP)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Platelet-rich-Plasma ZusammenfassungHintergrund und Ziel Platelet-rich-Plasma (PRP) scheint als eine autologe und minimalinvasive Behandlungsmethode eine geeignete Alternative zu den bisherigen Behandlungsformen darzustellen, um eine Regeneration im Bereich der unteren Augenpartie erzielen zu können. Erklärt wird die Wirkung von PRP besonders in Bezug auf die Behandlung von Elastizitätsmangel und Volumendefizit im Bereich der Unterlider, für die es derzeit wenig andere Behandlungsalternativen gibt. Das körpereigene Produkt, das aus hoch konzentriertem thrombozytenreichem Plasma beste... περισσότερα »
Tracheostomie versus perkutane Dilatationstracheotomie
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Tracheostomie versus perkutane Dilatationstracheotomie Zusammenfassung Zur Anlage eines Luftröhrenschnitts gibt es zurzeit viele Indikationen und unterschiedliche Vorgehensweisen. Die Regie im Rahmen einer interdisziplinären Indikationsstellung, bei der Auswahl des operativen Verfahrens, bei der Versorgung der tracheotomierten Patienten, insbesondere bei der Behandlung von typischen Problemen am Tracheostoma und von Komplikationen sollte beim HNO-Arzt liegen. Im Notfallmanagement stehen zunächst verschiedene nichtchirurgische Maßnahmen wie die Maskenbeatmung, die Intubation und extra... περισσότερα »
Ästhetische Chirurgie
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Roboterassistierte Haartransplantation Zusammenfassung Die roboterassistierte Haarwurzelentnahme (FUE) ist eine echte Neuerung und Bereicherung im Prozess der Eigenhaarwurzeltransplantation. Das ARTAS-Robotersystem arbeitet sicher und mit sehr geringer Verletzungsrate für die Haarwurzelschäfte. Die meisten FUE-Haarpatienten stehen dem System positiv und aufgeschlossen gegenüber. Der Roboter erfordert ein gut geschultes und erfahrenes Team, welches sich täglich ausschließlich mit Haartransplantationen beschäftigen sollte. Es bleibt abzuwarten, ob nach Vergleich mit entsprechend hohen ... περισσότερα »
An iatrogenic foreign body in Stensen's duct: a stone and broken wire basket
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Clinical RecordSialendoscopy-assisted transfacial surgery for the removal of an iatrogenic foreign body in Stensen's duct: a stone and broken wire basketP Capaccioa1a2, M Gaffuria1a3 c1, S Torrettaa1a3 and L Pignataroa1a3 a1 Department of Otolaryngology and Head and Neck Surgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy a2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy a3 Department of Clinical Sciences and Community Health, University of Milan, Italy Abstract Background: A foreign body is a rare cause of parotid gland ...περισσότερα »
Treatment of severe recurrent hepatitis C after liver transplantation in HIV infected patients using sofosbuvir-based therapy
Alexandros G. SfakianakisστοΘεραπείαΠριν από 26 δευτερόλεπτα
Summary Background For liver transplant recipients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection, recurrence after LT is associated with a higher risk of graft loss than for HCV mono-infected patients. Prior HCV treatment options were limited by side effects and drug–drug interactions. Aim To evaluate treatment outcomes with sofosbuvir (SOF)-based therapy among HIV/HCV coinfected liver transplant recipients. Methods Access to SOF and ribavirin (RBV) prior to regulatory approval was attained via an international compassionate access program for... περισσότερα »
Sialendoscopy-assisted transfacial surgery for the removal of an iatrogenic foreign body in Stensen's duct
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Clinical RecordSialendoscopy-assisted transfacial surgery for the removal of an iatrogenic foreign body in Stensen's duct: a stone and broken wire basketP Capaccioa1a2, M Gaffuria1a3 c1, S Torrettaa1a3 and L Pignataroa1a3 a1 Department of Otolaryngology and Head and Neck Surgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy a2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy a3 Department of Clinical Sciences and Community Health, University of Milan, Italy Abstract Background: A foreign body is a rare cause of parotid gland ...περισσότερα »
Nasal function and dysfunction in exercise
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Review ArticlesNasal function and dysfunction in exerciseA Walkera1 c1, P Surdaa1, M Rossitera2 and S Littlea1 a1 Department of ENT Surgery, St George's Hospital, London, UK a2 All Sports Medicine, Candover Clinic, Basingstoke and North Hampshire Hospital, Basingstoke, UK Abstract Background: There have been recent advances in our appreciation of the functional complementarity of the upper and lower airways. The unified airway begins at the nose: rather than acting merely as a conduit for air to the lungs, the nose and nasal cavity perform an important role in filtering, humidificatio...περισσότερα »
Olfactory event-related potentials
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Main ArticlesOlfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapyB Gallettia1, R Santoroa1, V K Mannellaa1, F Caminitia2, L Bonannoa2, S De Salvoa2, G Cammarotoa1 c1 and F Gallettia1 a1 Department of Otorhinolaryngology, University of Messina, Messina, Italy a2 Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy Abstract Objective: Olfactory dysfunction is a possible side effect of chemo-radiotherapy perfor...περισσότερα »
Transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Main ArticlesIn defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibromaA Mishraa1 c1, S C Mishraa1a2, V Vermaa1, H P Singha1, S Kumara1, A M Tripathia1, B Patela1 and V Singha1 a1 Department of Otorhinolaryngology, King George Medical University, Lucknow, India a2 Visiting Professor at Nepalgunj Medical College, Nepal Abstract Background: Juvenile nasopharyngeal angiofibroma often presents with lateral extensions. In countries with limited resources, s...περισσότερα »
Transtympanic balloon dilatation of the eustachian tube
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Review ArticlesTranstympanic balloon dilatation of the eustachian tube: systematic reviewN Jufasa1a2a3 c1 and N Patela1a2a3 a1 Kolling Deafness Research Centre, University of Sydney and Macquarie University, Sydney, Australia a2 Discipline of Surgery, Sydney Medical School, University of Sydney, Australia a3 Sydney Endoscopic Ear Surgery (‘SEES’) Research Group, Australia Abstract Objective: To investigate the evidence for balloon dilatation of the eustachian tube using a transtympanic approach. Methods: A systematic search of several databases was conducted (using the search terms ‘di... περισσότερα »
Hypothyroidism in patients treated with radiotherapy for HNC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Main ArticlesHypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up studyJ R Albaa1 c1, J Basterraa1, J C Ferrera2, F Santonjaa3 and E Zapatera1 a1 Department of ENT, University General Hospital, Valencia Medical School, Spain a2 Department of Endocrinology, University General Hospital, Valencia Medical School, Spain a3 Department of Statistics and Operations Research, University of Valencia, Spain Abstract Objective: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours.... περισσότερα »
Dihydroergotamine Tartrate Induces Cancer Cell Death through Apoptosis and Mitophagy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Lung Cancer Cell Death *Background:* Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. *Methods:* We examined the effect of DHE on the survival of several lung cancer cells and confirmed that DHE suppressed diverse lung cancer cell growth effectively. To confirm whether such effects of DHE would be associated with mitochondria, A549 cells were employed for the evaluation of sev... περισσότερα »
Laser penetration in the tissue
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
The effects of ultrasound and alternating current on the laser penetration in the tissue: AbstractThe visible (VIS) and near-infrared (NIR) lasers are now widely used in therapeutic and other medical applications. Some of these applications require to deliver the laser energy deep toward the desired tissue target or organ. The aim of this in vitro study is to investigate practically whether the modulation of laser energy by employing the therapeutic ultrasound or electrical energies can increase the penetration depth of the laser light inside the tissue. Such modulation was impleme... περισσότερα »
Supraspinal control of automatic postural responses
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
in people with multiple sclerosis via Gait & Posture Publication date: Available online 20 April 2016 *Source:*Gait & Posture Author(s): D.S. Peterson, G. Gera, F.B. Horak, B.W. Fling The neural underpinnings of delayed automatic postural responses in people with multiple sclerosis (PwMS) are unclear. We assessed whether white matter pathways of two supraspinal regions (the cortical proprioceptive Broadman's Area-3; and the balance/locomotor-related pedunculopontine nucleus) were related to delayed postural muscle response latencies in response to external perturbations. 19 PwMS (48.8... περισσότερα »
Treatment of severe recurrent hepatitis C after liver transplantation in HIV infected patients using sofosbuvir-based therapy
Alexandros G. SfakianakisστοThe OesophagusΠριν από 34 δευτερόλεπτα
Summary Background For liver transplant recipients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection, recurrence after LT is associated with a higher risk of graft loss than for HCV mono-infected patients. Prior HCV treatment options were limited by side effects and drug–drug interactions. Aim To evaluate treatment outcomes with sofosbuvir (SOF)-based therapy among HIV/HCV coinfected liver transplant recipients. Methods Access to SOF and ribavirin (RBV) prior to regulatory approval was attained via an international compassionate access program for... περισσότερα »
Small Lymphocytic Lymphoma Presenting with Hypopituitarism.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Small Lymphocytic Lymphoma Presenting with Hypopituitarism.* Am J Med. 2016 Jan;129(1):e9-e10 Authors: Moore JA, Moore MB, Samaniego F, Pinnix CC, Moore DF PMID: 26344628 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1itXsYs via IFTTT
Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.* J Clin Neurosci. 2015 Jul;22(7):1188-90 Authors: Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN Abstract We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with isolated ipsilateral facial pain mimicking trigeminal neuralgia due to invasion of Meckel's cave but subsequently progressing to intra-axial extension and having syn... περισσότερα »
B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity.* Gene Ther. 2015 Aug;22(8):675-84 Authors: Wu MR, Zhang T, DeMars LR, Sentman CL Abstract Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. A CAR strategy can target any tumor surface antigens as long as an antigen-binding receptor can be generated. New CARs that target solid tum... περισσότερα »
Prognostic Role of Glasgow Prognostic Score in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Prognostic Role of Glasgow Prognostic Score in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.* Medicine (Baltimore). 2015 Dec;94(49):e2133 Authors: Li MX, Bi XY, Li ZY, Huang Z, Han Y, Zhou JG, Zhao JJ, Zhang YF, Zhao H, Cai JQ Abstract Conflicting results about the prognostic value of Glasgow Prognostic Score (GPS) in hepatocellular carcinoma (HCC) patients have been reported. We searched the available articles and performed the meta-analysis to clarify the predictive value of GPS... περισσότερα »
Formulation design in vitro characterizations and anti-malarial investigations of artemether and lumefantrine-entrapped solid lipid microparticles.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Formulation design, in vitro characterizations and anti-malarial investigations of artemether and lumefantrine-entrapped solid lipid microparticles.* Drug Dev Ind Pharm. 2016 Apr 19;:1-14 Authors: Agbo C, Umeyor C, Kenechukwu F, Ogbonna J, Chime S, Lovelyn C, Agubata O, Ofokansi K, Attama A Abstract CONTEXT: Poor aqueous solubility of artemether and lumefantrine makes it important to seek better ways of enhancing their oral delivery and bioavailability. OBJECTIVE: To formulate and carry out in vitro and anti-malarial pharmacodynamic evaluations of solidified reverse micellar sol...περισσότερα »
High throughput research and evaporation rate modeling for solvent screening for ethylcellulose barrier membranes in pharmaceutical applications.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*High throughput research and evaporation rate modeling for solvent screening for ethylcellulose barrier membranes in pharmaceutical applications.* Drug Dev Ind Pharm. 2016 Apr 19;:1-8 Authors: Schoener CA, Curtis-Fisk JL, Rogers TL, Tate MP Abstract CONTEXT: Ethylcellulose is commonly dissolved in a solvent or formed into an aqueous dispersion and sprayed onto various dosage forms to form a barrier membrane to provide controlled release in pharmaceutical formulations. Due to the variety of solvents utilized in the pharmaceutical industry and the importance solvent can play on fi...περισσότερα »
Flow and compaction properties of hypromellose: new directly compressible versus the established grades.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Flow and compaction properties of hypromellose: new directly compressible versus the established grades.* Drug Dev Ind Pharm. 2016 Apr 19;:1-39 Authors: Grdešič P, Vrečer F, Ilić I Abstract CONTEXT: Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for technologists who are facing challenges regarding poor flow and compaction while developing new controlled release matrix tablets. There is a profound lack of studies in this field and none of the published ones deal with the compaction of the newly introduced HPMC grades specifically de... περισσότερα »
On-line monitoring of vacuum drying of theophylline using NIR Spectroscopy: solid-state transitions water content and semi-empirical modeling.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*On-line monitoring of vacuum drying of theophylline using NIR Spectroscopy: solid-state transitions, water content and semi-empirical modeling.* Drug Dev Ind Pharm. 2016 Apr 19;:1-23 Authors: Amira T, Peczalski R, Zagrouba F Abstract The aim of this work was to monitor in-line and at a real time, the solid-state forms during pharmaceuticals manufacturing. It concerns the dehydration behaviour and the solid-state transitions of theophylline in an agitated vacuum contact dryer. First, a Near Infra-Red Spectroscopy (NIRS) method was performed using a reflectance diffuse probe to me... περισσότερα »
Nanoparticles as tool for enhanced ophthalmic delivery of vancomycin: a multidistrict-based microbiological study solid lipid nanoparticles formulation and evaluation.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Nanoparticles as tool for enhanced ophthalmic delivery of vancomycin: a multidistrict-based microbiological study, solid lipid nanoparticles formulation and evaluation.* Drug Dev Ind Pharm. 2016 Apr 19;:1-11 Authors: Yousry C, Fahmy RH, Essam T, El-Laithy HM, Elkheshen SA Abstract CONTEXT: A microbiological multidistrict-based survey from different Egyptian governorates was conducted to determine the most prevalent causative agents of ocular infections in the Egyptian population. Antibiotic sensitivity testing was then performed to identify the most potent antimicrobial agent. V...περισσότερα »
Effect of Different Surface Treatments on the Bond Strength of Lithium Disilicate Ceramic to the Zirconia Core.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Effect of Different Surface Treatments on the Bond Strength of Lithium Disilicate Ceramic to the Zirconia Core.* Photomed Laser Surg. 2016 Apr 20; Authors: Yilmaz-Savas T, Demir N, Ozturk AN, Kilic HS Abstract OBJECTIVE: The aim of this study was to evaluate the effect of different surface treatments [sandblasting, Erbium:Yttrium-Aluminium-Garnet (Er:YAG), and femtosecond lasers] on the shear bond strength (SBS) of the CAD-on technique. BACKGROUND DATA: Although demand for all-ceramic restorations has increased, chipping remains one of the major problems for zirconia-based resto...περισσότερα »
Revisiting autophagy addiction of tumor cells.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Revisiting autophagy addiction of tumor cells.* Autophagy. 2016 Apr 20;:0 Authors: Nyfeler B, Eng CH PMID: 27097231 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/26gqSxP via IFTTT
miR-487b-5p Regulates Temozolomide Resistance of Lung Cancer Cells Through LAMP2-Medicated Autophagy.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*miR-487b-5p Regulates Temozolomide Resistance of Lung Cancer Cells Through LAMP2-Medicated Autophagy.* DNA Cell Biol. 2016 Apr 20; Authors: Bao L, Lv L, Feng J, Chen Y, Wang X, Han S, Zhao H Abstract Temozolomide (TMZ) is a standard agent used in the treatment of various types of cancers, including lung carcinoma, but TMZ resistance is common and accounts for many treatment failures. We investigated miRNA-487b-5p (miR-487b-5p) was highly expressed in A549 and H1299 cells which acquired TMZ resistance. Suppression of miR-487b-5p had overt effects on cellular proliferation and mig... περισσότερα »
Selective sorting and destruction of mitochondrial membrane proteins in aged yeast.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Selective sorting and destruction of mitochondrial membrane proteins in aged yeast.* Elife. 2016 Apr 20;5 Authors: Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE Abstract Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial proteome or alter mitochondrial content during times of stress or metabolic adaptation. Here, using yeast as a model system, we identify a new mitochondrial degradation system that remodels the mitoc...περισσότερα »
Targeting the MIR34C-5p-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Targeting the MIR34C-5p-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin.* Autophagy. 2016 Apr 20;:0 Authors: Wu Y, Ni Z, Yan X, Dai X, Hu C, Zheng Y, He F, Lian J Abstract Pirarubicin (THP) is a newer generation anthracycline anticancer drug. In the clinic, THP and THP-based combination therapies have been demonstrated to be effective against various tumors without severe side effects. However, previous clinical studies have shown that most patients with cervical cancer are not sensitive to THP treatment, and the associated mechanisms are no...περισσότερα »
Autophagy Initiation Correlates with the Autophagic Flux in 3D Models of Mesothelioma and with Patient Outcome.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Autophagy Initiation Correlates with the Autophagic Flux in 3D Models of Mesothelioma and with Patient Outcome.* Autophagy. 2016 Apr 20;:0 Authors: Follo C, Barbone D, Richards WG, Bueno R, Broaddus VC Abstract Understanding the role of autophagy in cancer has been limited by the inability to measure this dynamic process in formalin-fixed tissue. We considered that 3-dimensional models including ex vivo tumor, such as we have developed for studying mesothelioma, would provide valuable insights. Using these models, in which we could use lysosomal inhibitors to measure the autopha...περισσότερα »
Vimentin in Bacterial Infections.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Vimentin in Bacterial Infections.* Cells. 2016;5(2) Authors: Mak TN, Brüggemann H Abstract Despite well-studied bacterial strategies to target actin to subvert the host cell cytoskeleton, thus promoting bacterial survival, replication, and dissemination, relatively little is known about the bacterial interaction with other components of the host cell cytoskeleton, including intermediate filaments (IFs). IFs have not only roles in maintaining the structural integrity of the cell, but they are also involved in many cellular processes including cell adhesion, immune signaling, and ... περισσότερα »
KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment.* Cancers (Basel). 2016;8(4) Authors: Zeitouni D, Pylayeva-Gupta Y, Der CJ, Bryant KL Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers with a dismal 7% 5-year survival rate and is projected to become the second leading cause of cancer-related deaths by 2020. KRAS is mutated in 95% of PDACs and is a well-validated driver of PDAC growth and maintenance. However, despite comprehensive efforts, an effective anti-RAS drug has yet to reach the clinic. Different paths to inhibiting RAS s...περισσότερα »
Downregulation of autophagy through CUL3-KLHL20 mediated turnover of the ULK1 and PIK3C3/VPS34 complexes.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Downregulation of autophagy through CUL3-KLHL20 mediated turnover of the ULK1 and PIK3C3/VPS34 complexes.* Autophagy. 2016 Apr 20;:0 Authors: Feng Y, Klionsky DJ PMID: 27096860 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1YIr973 via IFTTT
The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses.* Autophagy. 2016 Apr 20;:0 Authors: Cui J, Jin S, Wang RF Abstract Macroautophagy/autophagy is a conserved intracellular degradation system that traffics substrates including protein aggregates, defunct or dis-used organelles and invading pathogens to lysosomes via double-membrane vesicles called autophagosomes. BECN1/Beclin-1 functions as a key protein in autophagy initiation and progression; however, the role of BECN1 in innate immunity has not been fully investigated. Recently...περισσότερα »
Promotion of Pro-Apoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy.
Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα
*Promotion of Pro-Apoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy.* Photochem Photobiol. 2016 Apr 20; Authors: Kessel D, Evans CL Abstract Prior studies demonstrated that a low level (LD10-15 ) of lysosomal photodamage can sensitize cells to the apoptotic death that results from subsequent mitochondrial photodamage. We have proposed that this process occurs via a calpain-catalyzed cleavage of the autophagy-associated protein ATG5 to form a pro-apoptotic fragment. In this report, we provide evidence for the postulated ATG5 cleavage and sh...περισσότερα »
[Variation of extralaryngeal furcation of the recurrent laryngeal nerve in total thyroidectomy].
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
*[Variation of extralaryngeal furcation of the recurrent laryngeal nerve in total thyroidectomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;29(24):2163-5 Authors: Fan Z, Zhang L, Zhang Y Abstract OBJECTIVE: To explore the extralaryngeal furcation variation of the recurrent laryngeal nerve (RLN) in total thyroidectomy. METHOD: The clinical data of 216 RLNs from 108 patients undergone total thyroidectomy were retrospectively analyzed. RESULT: RLN was found during every operation and exposed in whole course until access into larynx. Twenty (9.26%) pieces of RLNs showed...περισσότερα »
The Long-Term Prognosis of Voice Pitch Change in Female Patients After Thyroid Surgery.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
*The Long-Term Prognosis of Voice Pitch Change in Female Patients After Thyroid Surgery.* World J Surg. 2016 Apr 19; Authors: Park JO, Bae JS, Lee SH, Shim MR, Hwang YS, Joo YH, Park YH, Sun DI Abstract BACKGROUND: Relatively large numbers of patients complain of lower-pitched voices after thyroidectomy. However, little is known about the risk factors for, prognosis of, or progression over time of, such changes, in female patients. METHODS: We analyzed the data of 217 patients who underwent thyroid surgery and postoperative (2 weeks, and 3, 6, and 12 months after surgery) voice w...περισσότερα »
[Surgical management of primary hyperthyroidism and coexistent thyroid carcinoma].
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
*[Surgical management of primary hyperthyroidism and coexistent thyroid carcinoma].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Apr 7;51(4):273-6 Authors: Shen H, Wei BB, Xie H, Peng ZX, Wang J, Bai J Abstract OBJECTIVE: To evaluated the results of surgical treatment for primary hyperparathyroidism coexistent with thyroid cancer. METHODS: From March 2007 to May 2014, 27 patients suffered thyroid carcinoma coexistent with primary hyperparathyroidism with pathological and laboratory confirmation were studied retrospectively. In 8 of 27 cases thyroidectomy and parathyroidect...περισσότερα »
[Clinical analysis of lymphocytic thyroiditis coexistent with papillary thyroid carcinoma].
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
*[Clinical analysis of lymphocytic thyroiditis coexistent with papillary thyroid carcinoma].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Apr 7;51(4):277-81 Authors: Wang SX, She ZQ, An CM, Zhang XW, Li ZJ, Tang PZ Abstract OBJECTIVE: To analyse the clinical features and treatment strategies of papillary thyroid carcinoma(PTC) coexistent with lymphocytic thyroiditis (LT). METHODS: A total of 292 patients including 25 males and 267 females with LT and thyroid nodules treated in the department of head and neck surgery between Sep 2011 and Sep 2014 was analysed retrospectivel...περισσότερα »
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Khandelwal AR, Ma X, Egan P, Kaskas NM, Moore-Medlin T, Caldito G, Abreo F, Gu X, Aubrey L, Milligan E, Nathan CO Abstract OBJECTIVE: Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and ...περισσότερα »
Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.* Int Arch Otorhinolaryngol. 2016 Apr;20(2):151-5 Authors: Chiesa Estomba CM, Reinoso FA, Velasquez AO, Fernandez JL, Conde JL, Hidalgo CS Abstract Introduction Transoral laser microsurgery (TLM) has established itself as an effective option in the management of malignant tumors of the glottis, supraglottis, and hypopharynx. Nonetheless, TLM is not a harmless technique. Complications such as bleeding, dyspnea, or ignition of the air may appear in this type of surgery. Objective The aim of this study is to de... περισσότερα »
Occult level IV metastases in clinically node-negative patients with oral tongue squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Occult level IV metastases in clinically node-negative patients with oral tongue squamous cell carcinoma.* J Laryngol Otol. 2016 May;130(5):474-7 Authors: Motiee-Langroudi M, Amali A, Saedi B, Emami H, Ensani F, Lotfi A, Rabbani Anari M Abstract OBJECTIVE: The present study was conducted to determine the rate of level IV lymph node involvement among node-negative (N0) necks in patients with squamous cell carcinoma of the tongue. METHODS: The study comprised 32 patients with squamous cell carcinoma of the tongue, with tumour-node-metastasis staging of T1-3N0M0, who were admitted ... περισσότερα »
PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma.* Oncotarget. 2016 Apr 15; Authors: Kim HS, Lee SE, Bae YS, Kim DJ, Lee CG, Hur J, Chung H, Park JC, Shin SK, Lee SK, Lee YC, Kim HR, Shim YM, Jewell SS, Kim H, Choi YL, Cho BC Abstract To investigate the clinicopathologic characteristics and the prognostic impact of PIK3CA gene amplification in curatively resected esophageal squamous cell carcinoma (ESCC). Using 534 curatively resected ESCCs, the PIK3CA gene copy number was evaluated with fluorescent ...περισσότερα »
Alcohol and survival in ESCC: Prediagnosis alcohol consumption and postoperative survival in lymph node-negative esophageal carcinoma patients.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Alcohol and survival in ESCC: Prediagnosis alcohol consumption and postoperative survival in lymph node-negative esophageal carcinoma patients.* Oncotarget. 2016 Apr 15; Authors: Ma Q, Liu W, Jia R, Long H, Zhang L, Lin P, Zhao H, Ma G Abstract BACKGROUND: The association between esophageal cancer and prediagnosis alcohol consumption is well established. However, evidence that prediagnosis alcohol consumption affects postoperative survival in patients with lymph node-negative esophageal squamous cell carcinoma (ESCC) is lacking. We conducted a retrospective study on the effect o... περισσότερα »
Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells.* Oncotarget. 2016 Apr 16; Authors: Liu S, Zhou F, Shen Y, Zhang Y, Yin H, Zeng Y, Liu J, Yan Z, Liu X Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly diagnosed malignancies with high occurrence of tumor metastasis, which usually exposes to fluid shear stress (FSS) in lymphatic channel and blood vessel. Epithelial-mesenchymal transition (EMT) is an important mechanism that induces metastasis and invasion of tumors. We hypothesized that FSS induced a progression of EMT ...περισσότερα »
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Yang SF, Bier-Laning CM, Adams W, Zilliox MJ Abstract OBJECTIVES: (1) Reanalyze publicly available genomic data for HPV-negative oral cavity squamous cell carcinoma to look for candidate biomarkers. (2) Evaluate the association of the identified biomarkers with survival. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary care. SUBJECTS AND METHODS: Gene expression barcode analysis was applied to an existing publicly... περισσότερα »
Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
*Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Khandelwal AR, Ma X, Egan P, Kaskas NM, Moore-Medlin T, Caldito G, Abreo F, Gu X, Aubrey L, Milligan E, Nathan CO Abstract OBJECTIVE: Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and ...περισσότερα »
Three-dimensional endoscopic visualization in functional endoscopic sinus surgery.
Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα
*Three-dimensional endoscopic visualization in functional endoscopic sinus surgery.* Eur Arch Otorhinolaryngol. 2016 Apr 19; Authors: Albrecht T, Baumann I, Plinkert PK, Simon C, Sertel S Abstract Three-dimensional (3D) stereoscopic vision in sinus surgery has been achieved with the microscope so far. The introduction of two-dimensional (2D) endoscopes set a milestone in the visualization of the surgical field and paved the way to functional endoscopic sinus surgery (FESS), although the 2D endoscopes cannot provide a stereoscopic visualization. The latest technology of 3D endosco...περισσότερα »
Satisfaction and compliance of adult patients using hearing aid and evaluation of factors affecting them.
Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα
*Satisfaction and compliance of adult patients using hearing aid and evaluation of factors affecting them.* Eur Arch Otorhinolaryngol. 2016 Apr 19; Authors: Korkmaz MH, Bayır Ö, Er S, Işık E, Saylam G, Tatar EÇ, Özdek A Abstract The aims of this study are to reveal patient compliance and satisfaction in hearing aid-prescribed adult population and to determine the relevant clinical factors. The study was designed retrospectively, and those patients who have been using hearing aid for at least 6 months were invited for evaluation. Demographical data, hearing aid type (digital vs ana...περισσότερα »
Signaling pathways in diabetic nephropathy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα
*Signaling pathways in diabetic nephropathy.* Histol Histopathol. 2016 Apr 20;:11777 Authors: Kawanami D, Matoba K, Utsunomiya K Abstract Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however, specific treatment for DN has not yet been elucidated. Therefore, it is critically important to understand the molecular mechanism underlying DN to develop cause-related therapeutic strategy. To date, various factors such as hemodynamic changes and metabolic pathways have been shown to be involved in the pathogenesis of DN. Excessive glucose influx activates ...περισσότερα »
Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center.
Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα
*Outcomes Following Pediatric Auditory Brainstem Implant Surgery: Early Experiences in a North American Center.* Otolaryngol Head Neck Surg. 2016 Apr 19; Authors: Puram SV, Barber SR, Kozin ED, Shah P, Remenschneider A, Herrmann BS, Duhaime AC, Barker FG, Lee DJ Abstract There are no approved Food and Drug Administration indications for pediatric auditory brainstem implant (ABI) surgery in the United States. Our prospective case series aims to determine the safety and feasibility of ABI surgery in pediatric patients <5 years old with congenital deafness at a tertiary North Americ... περισσότερα »
Weight estimation methods in children: a systematic review
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VHBKRK via IFTTT
Role of heparin during endovascular therapy for acute ischemic stroke
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Clinical Neurology and Neurosurgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QpimRt via IFTTT
Effects of facet joint injection reducing the need for percutaneous vertebroplasty in vertebral compression fractures
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Cardiovascular and Interventional Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VHBMsM via IFTTT
Epidemiologic study in hospitalized patients with head injuries
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
European Journal of Trauma and Emergency Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QpimB3 via IFTTT
Early Electroencephalographic Background Features Predict Outcomes in Children Resuscitated From Cardiac Arrest.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Objectives: To determine 1) whether early electroencephalographic background features were associated with survival and neurologic outcomes among children resuscitated from cardiac arrest and not treated with therapeutic hypothermia and 2) if addition of electroencephalographic background to commonly used clinical criteria is more predictive of outcome than clinical criteria alone. Design: Retrospective study. Setting: PICU and Cardiac ICUs of a tertiary children's hospital. Patients: Patients resuscitated from in-hospital or out-of-hospital cardiac arrest who underwent clinically i... περισσότερα »
Early Electroencephalographic Background Features Predict Outcomes in Children Resuscitated From Cardiac Arrest.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Objectives: To determine 1) whether early electroencephalographic background features were associated with survival and neurologic outcomes among children resuscitated from cardiac arrest and not treated with therapeutic hypothermia and 2) if addition of electroencephalographic background to commonly used clinical criteria is more predictive of outcome than clinical criteria alone. Design: Retrospective study. Setting: PICU and Cardiac ICUs of a tertiary children's hospital. Patients: Patients resuscitated from in-hospital or out-of-hospital cardiac arrest who underwent clinically i... περισσότερα »
Long-Term Follow-Up with Video of a Patient with Deafness-Dystonia Syndrome Treated with DBS-GPi
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Background: The prevalence of deafness-dystonia syndrome (DDS) is relatively low. To our knowledge, only 2 cases of this syndrome treated with deep brain stimulation (DBS) have been reported. Objectives: We present a patient with DDS of unknown cause, refractory to medical treatment, who has been successfully treated with DBS of the internal globus pallidus (DBS-GPi) […]
Role of mast cells in fibrosis of classical Hodgkin lymphoma.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Role of mast cells in fibrosis of classical Hodgkin lymphoma. Int J Immunopathol Pharmacol. 2016 Apr 19; Authors: Nakayama S, Yokote T, Hiraoka N, Nishiwaki U, Hanafusa T, Nishimura Y, Tsuji M Abstract The underlying mechanism of fibrosis in classical Hodgkin lymphoma (CHL) remains uncertain. This study aimed to investigate the association of fibrosis in […]
Kann der Plastische Chirurg Leiter des Departments für Chirurgie an einer Universitätsklinik sein?..Das funktioniert wirklich?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Kann der Plastische Chirurg Leiter des Departments für Chirurgie an einer Universitätsklinik sein?……..Das funktioniert wirklich? Handchir Mikrochir Plast Chir. 2016 Apr;48(2):69-72 Authors: Neumeister MW Abstract There is significant responsibility in being a Department of Surgery Chairman within a medical school. The Chairman is appointed by the Dean of Medicine to lead surgery in a path […]
‘Don’t play the butter notes’: jazz in medical education.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
‘Don’t play the butter notes’: jazz in medical education. Med Educ Online. 2016;21:30582 Authors: Bradner M, Harper DV, Ryan MH, Vanderbilt AA Abstract Jazz has influenced world music and culture globally – attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education […]
125I Brachytherapy in Locally Advanced Nonsmall Cell Lung Cancer After Progression of Concurrent Radiochemotherapy.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Related Articles 125I Brachytherapy in Locally Advanced Nonsmall Cell Lung Cancer After Progression of Concurrent Radiochemotherapy. Medicine (Baltimore). 2015 Dec;94(49):e2249 Authors: Xiang Z, Li G, Liu Z, Huang J, Zhong Z, Sun L, Li C, Zhang F Abstract To investigate the safety and effectiveness of computed tomography (CT)-guided I seed implantation for locally advanced nonsmall […]
What motivates doctors to leave the UK NHS for a «life in the sun» in New Zealand; and once there why don’t they stay?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Related Articles What motivates doctors to leave the UK NHS for a «life in the sun» in New Zealand; and, once there, why don’t they stay? Hum Resour Health. 2015;13:75 Authors: Gauld R, Horsburgh S Abstract BACKGROUND: At 44%, New Zealand has the highest proportion of international medical graduates (IMGs) in its workforce amongst OECD […]
Patient-Reported Discharge Readiness and 30-Day Risk of Readmission or Death: AProspective Cohort Study.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Related Articles Patient-Reported Discharge Readiness and 30-Day Risk of Readmission or Death: A Prospective Cohort Study. Am J Med. 2016 Jan;129(1):89-95 Authors: Lau D, Padwal RS, Majumdar SR, Pederson JL, Belga S, Kahlon S, Fradette M, Boyko D, McAlister FA Abstract BACKGROUND: Early readmissions to hospital after discharge are common, and clinicians cannot accurately predict […]
A Context-Aware Interactive Health Care System Based on Ontology and Fuzzy Inference.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Related Articles A Context-Aware Interactive Health Care System Based on Ontology and Fuzzy Inference. J Med Syst. 2015 Sep;39(9):105 Authors: Chiang TC, Liang WH Abstract In the present society, most families are double-income families, and as the long-term care is seriously short of manpower, it contributes to the rapid development of tele-homecare equipment, and the […]
An inventory model for controllable probabilistic deterioration rate under shortages
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 57 δευτερόλεπτα
Abstract This article presents a production inventory model for three level production rates with characterizing the preservation technology for deteriorating items to reduce the deterioration rate. The deterioration of the product is considered as probabilistic to make the research a more realistic one. In this paper, a production inventory model with deteriorative items in which three different rates of productions are considered. Two models are considered; the production inventory model without shortages is studied first and with shortages is investigated next. In this paper, s... περισσότερα »
An 8-Year-Old Boy with an Enlarging Mass in the Right Breast
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
Presentation of Case. Dr. Charumathi Baskaran (Pediatrics): An 8-year-old boy was seen in an outpatient clinic of this hospital because of an enlarging mass in the right breast. One week before this presentation, the patient was seen by a pediatrician at another medical facility for a routine… from Cases via ola Kala on Inoreader http://ift.tt/20ZGcel via IFTTT
Retroauricular Endoscope-Assisted Approach to the Neck: Early Experience in Latin America.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα
*Retroauricular Endoscope-Assisted Approach to the Neck: Early Experience in Latin America.* Int Arch Otorhinolaryngol. 2016 Apr;20(2):138-44 Authors: Lira RB, Chulam TC, Koh YW, Choi EC, Kowalski LP Abstract Introduction There has been a significant increase in concern towards improving aesthetic and functional outcomes without compromising the oncologic effectiveness in head and neck surgery. In this subset, endoscope-assisted and robotic procedures allowed the development of new approaches to the neck, including the retroauricular access, which is now routinely used, especiall... περισσότερα »
Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!* J Pediatr Adolesc Gynecol. 2015 Jun;28(3):e83-5 Authors: Bhagwat NM, Dalwadi PP, Joshi AS, Pawal PS, Varthakavi PK Abstract BACKGROUND: Van Wyk-Grumbach syndrome is a rare complication of prolonged untreated primary hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. High index of suspicion and timely diagnosis can prevent unnecessary surgical procedures because this condition can be reversed with thyroid hormone supp... περισσότερα »
Response to Treatment is Highly Predictable in cN0 Patients with Papillary Thyroid Carcinoma.
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα
*Response to Treatment is Highly Predictable in cN0 Patients with Papillary Thyroid Carcinoma.* World J Surg. 2016 Apr 19; Authors: Gorshtein A, Benbassat C, Robenshtok E, Shimon I, Hirsch D Abstract BACKGROUND: While involvement of macrometastatic lymph nodes is a recognized independent predictor of an adverse course in papillary thyroid cancer (PTC) patients, the clinicopathological variables associated with disease persistence/recurrence in clinically node-negative (cN0) disease are not well defined. The indications for prophylactic central neck dissection (pCND) in this patie... περισσότερα »
A central hypothyroidism induced by oxcarbazepine therapy
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα
2016-04-21T02-46-27Z *Source:* Case Study and Case Report Hye Young Jin, Yun Jung Hur. Antiepileptic drugs lead to various degrees of impairment in thyroid hormone homeostasis. In general, slightly low thyroxine (T4) and elevated thyroid stimulating hormone (TSH) levels have been reported because induced hepatic enzymes contribute to the clearance of thyroid hormone. On the other hand, it was thought that oxcarbazepine (OXC) could suppress the hypothalamus-pituitary axis, resulting in the decreased responsiveness of thyrotropin-releasing hormone-thyrotropin. A twelve-year-old girl b...περισσότερα »
Radiofrequency ablation for benign thyroid nodules
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD)...περισσότερα »
Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma.* J Clin Pathol. 2016 Apr 19; Authors: Baillie R, Itinteang T, Yu HH, Brasch HD, Davis PF, Tan ST PMID: 27095085 [PubMed - as supplied by publisher] from squamous cell carcinoma via ok on Inoreader http://ift.tt/243Can0 via IFTTT
Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Complications in CO2 Laser Transoral Microsurgery for Larynx Carcinomas.* Int Arch Otorhinolaryngol. 2016 Apr;20(2):151-5 Authors: Chiesa Estomba CM, Reinoso FA, Velasquez AO, Fernandez JL, Conde JL, Hidalgo CS Abstract Introduction Transoral laser microsurgery (TLM) has established itself as an effective option in the management of malignant tumors of the glottis, supraglottis, and hypopharynx. Nonetheless, TLM is not a harmless technique. Complications such as bleeding, dyspnea, or ignition of the air may appear in this type of surgery. Objective The aim of this study is to de... περισσότερα »
Assessing T-cell abundance in cutaneous squamous cell carcinoma: adding another string to your bow.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Assessing T-cell abundance in cutaneous squamous cell carcinoma: adding another string to your bow.* Exp Dermatol. 2016 Apr 20; Authors: Cruz JL, Wells JW Abstract The majority of tumours express antigens that can be recognized by host CD8(+) T cells. Indeed, tumour-specific T cells are readily detectable in the blood, lymph nodes and tumors of individuals with cancer. However, the spontaneous clearance of established tumours by endogenous immune mechanisms is rare indicating that cancers evade immune surveillance by establishing local immune tolerance through mechanisms that ar... περισσότερα »
#Aspirin use may help prevent bile duct cancer study finds https://t.co/cMuiZBz1Ee https://t.co/jLziSWu9eR
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
#Aspirin use may help prevent bile duct cancer, study finds https://t.co/cMuiZBz1Ee https://t.co/jLziSWu9eR from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/723073854436978688 via IFTTT
Stomach cancer diagnostics: New insights on stage of tumour growth
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Diagnosis of gastric cancer in the early stages is difficult because of the lack of simple and cheap methods of inspection and specific markers of gastric cancer while the symptoms of the disease are vague and tend to overlap with other common and benign… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QpfNif via IFTTT
Detecting when the most common skin cancer turns dangerous
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Most basal cell skin cancers are easily removed — those on the arm, leg or back. But when the cancer is on the eyelid or when it starts to invade surrounding tissue, it’s no longer straightforward. A team of researchers who specialise in treating… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MK0pCl via IFTTT
«The cellular receptors of exogenous RNA»
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
One of the key determinants of survival for organisms is proper recognition of exogenous and endogenous nucleic acids. Therefore, high eukaryotes developed a number of receptors that allow for discrimination between friend or foe DNA and RNA. Appearance of exogenous RNA in cytoplasm provides a signal of danger and triggers cellular responses that facilitate eradication… Continue reading Postepy Hig Med Dosw 2016; 70:337-348 «The cellular receptors of exogenous RNA»
«Consequences of extrahepatic manifestations of hepatitis C viral infection (HCV)»
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The hepatitis C virus (HCV) is a primarily hepatotropic virus. However, numerous extrahepatic symptoms are observed in patients chronically infected with HCV, e.g. cryoglobulinemia, lymphoproliferative disorders, kidney diseases, disturbances of the central and peripheral nervous system, thyroid gland, pancreas, lymph nodes and pituitary gland, that develop at various times after the infection. Complex mechanisms underlie… Continue reading Postepy Hig Med Dosw 2016; 70:349-360 «Consequences of extrahepatic manifestations of hepatitis C viral infection (HCV)»
Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Background Recurrent glioblastoma is associated with a poor overall survival. Antiangiogenic therapy results in a high tumor response rate but has limited impact on survival. Immunotherapy has emerged as an efficient treatment modality for some cancers, and preclinical evidence indicates that anti-VEGF(R) therapy can counterbalance the immunosuppressive tumor microenvironment. Methods We collected peripheral blood… Continue reading Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell ... περισσότερα »
Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Factor X deficiency (FXD) is a rare bleeding disorder, which can result in severe bleeding symptoms such as intracranial hemorrhage (ICH). The most common bleeding symptoms are epistaxis and gum bleeding. ICH is reported in 9–26% of all patients with FXD, mostly during the first month of life. Here, we present a rare case of… Continue reading Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature
Predictors of Processing-Based Task Performance in Bilingual and Monolingual Children
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα
[image: S00219924.gif] Publication date: Available online 20 April 2016 *Source:*Journal of Communication Disorders Author(s): Milijana Buac, Megan Gross, Margarita Kaushanskaya In the present study we examined performance of bilingual Spanish-English-speaking and monolingual English-speaking school-age children on a range of processing-based measures within the framework of Baddeley's working memory model. The processing-based measures included measures of short-term memory, measures of working memory, and a novel word-learning task. Results revealed that monolinguals outperformed ... περισσότερα »
Immediate and Sustained Improvement in Behavior and Life Quality by Adenotonsillectomy in Children With Sleep-Disordered Breathing.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Immediate and Sustained Improvement in Behavior and Life Quality by Adenotonsillectomy in Children With Sleep-Disordered Breathing.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Jeon YJ, Song JJ, Ahn JC, Kong IG, Kim JW, Park GH, Won TB Abstract Objectives: To investigate longitudinal changes in behavior and quality-of-life (QoL) in children with sleep disordered breathing (SDB) after adenotonsillectomy (AT). Methods: This study prospectively enrolled 148 children who underwent AT for SDB. Caregivers filled out Korean attention deficit hyperactivity disorder... περισσότερα »
Effect of a Chitosan Gel on Hemostasis and Prevention of Adhesion After Endoscopic Sinus Surgery.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Effect of a Chitosan Gel on Hemostasis and Prevention of Adhesion After Endoscopic Sinus Surgery.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Chung YJ, An SY, Yeon JY, Shim WS, Mo JH Abstract Objectives: Postoperative bleeding and adhesion formation are the two most common complications after endoscopic sinus surgery (ESS). The former sometimes can be life threatening and the latter is the most common reason requiring revision surgery. This study was designed to evaluate the effect of newly developed chitosan gel (8% carboxymethyl chitosan, Surgi shield) ... περισσότερα »
Effect of Chronic Rhinosinusitis With or Without Nasal Polyp on Quality of Life in South Korea: 5th Korea National Health and Nutrition Examination Survey Korean.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Effect of Chronic Rhinosinusitis With or Without Nasal Polyp on Quality of Life in South Korea: 5th Korea National Health and Nutrition Examination Survey Korean.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Kim DH, Han K, Kim SW Abstract Objectives: This is the first study of its kind to investigate the relationship between chronic rhinosinusitis (CRS) with or without nasal polyps (NP) and health-related quality of life (HRQoL) in the general adult Korean population. We sought to evaluate the association after adjustment for confounding factors. We also e... περισσότερα »
Cepstral Analysis of Voice in Patients With Thyroidectomy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Cepstral Analysis of Voice in Patients With Thyroidectomy.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Shin YJ, Hong KH Abstract Objectives: The vocal changes after a thyroidectomy are temporary and nonsevere, therefore, obtaining accurate analytical results on the pathological vocal characteristics following such a procedure is difficult. For a more objective acoustic analysis, this study used the cepstral analysis method to examine changes in the patients' voices during the perioperative period regarding sustained vowel phonation. Methods: The sustained ...περισσότερα »
The Effect of Tonsillectomy and Adenoidectomy on Right Ventricle Function and Pulmonary Artery Pressure by Using Doppler Echocardiography in Children.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *The Effect of Tonsillectomy and Adenoidectomy on Right Ventricle Function and Pulmonary Artery Pressure by Using Doppler Echocardiography in Children.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Acar OÇ, Üner A, Garça MF, Ece İ, Epçaçan S, Turan M, Kalkan F Abstract Objectives: The purpose of the present study is to emphasize the efficacy of the myocardial performance index and tricuspid annular plane systolic excursion (TAPSE) in the determination of impaired cardiac functions and recovery period following the treatment in children with adenoid and/or to...περισσότερα »
Oropharyngeal 24-Hour pH Monitoring in Children With Airway-Related Problems.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Oropharyngeal 24-Hour pH Monitoring in Children With Airway-Related Problems.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Mesallam TA Abstract Objectives: Diagnosis and clinical presentation of pediatric laryngopharyngeal reflux (LPR) is still controversial. The aims of this work were to study the possibility of performing 24-hour oropharyngeal pH monitoring for children in the outpatient clinic setup and to explore the results of this test in correlation to airway-related problems. Methods: In this descriptive qualitative study, 26 children suffering from... περισσότερα »
Effect of Octreotide Injection on Postoperative Drainage After Neck Dissection: A Preliminary Report of a Prospective Matched Case-Control Study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Effect of Octreotide Injection on Postoperative Drainage After Neck Dissection: A Preliminary Report of a Prospective, Matched Case-Control Study.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Ahn D, Jeon JH, Kim H, Sohn JH Abstract Objectives: Somatostatin inhibits lymph production and reduces lymph flow into the lymphatic duct. We hypothesized that octreotide, a long-acting somatostatin analog, would reduce drainage after neck dissection (ND) by reducing the overall lymphatic flow in the neck as well as thoracic duct flow. Methods: From 2012 to 2014, tota...περισσότερα »
Spontaneous Retropharyngeal and Mediastinal Emphysema.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Related Articles *Spontaneous Retropharyngeal and Mediastinal Emphysema.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Cho DY, Aaron GP, Shepard KG Abstract A 14-year-old girl with no significant medical history presented at Emergency Department with sore throat and odynophagia after one episode of nonviolent coughing. She denied any respiratory distress, voice change, foreign body ingestion, retching, substance abuse, dental procedures, or trauma. She was afebrile with normal oxygen saturation and physical examination including the head and neck was unremarkable with the exc... περισσότερα »
MAP2 splicing is altered in Huntington's disease
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Dendritic alteration of striatal medium spiny neurons is one of the earliest morphological abnormalities in Huntington's disease (HD). The main microtubule-associated protein in dendrites is MAP2. The low-molecular weight isoforms of MAP2 (LMW-MAP2) are the juvenile forms resulting from exclusion of the sequence encoded by exons E7-E9 and are downregulated after the early stages of neuronal development when E7-E9 exon-including high-molecular weight isoforms (HMW-MAP2) are favored. Splicing alteration has recently been proposed to contribute to HD in view of two pathogenic... περισσότερα »
Keratitis-ichthyosis-deafness syndrome with recurrent pneumonia but no mucocutaneous infection
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XJZgvb via IFTTT
Rituximab monotherapy to treat intravascular large B-cell lymphoma manifesting as pruritic calf patch in an elderly female
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/26gkVAS via IFTTT
Lymphedema-associated neutrophilic dermatosis: Two cases of localized Sweet syndrome on the lymphedematous lower limbs
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Neutrophilic dermatosis on the site of lymphedema is a rare condition and considered as a localized and less severe variant of Sweet syndrome. Only 13 cases of this variant have been reported after mastectomy for breast cancer in the English-language published work. However, this condition has never been described on the lower limbs or from other causes of lymphedema. Herein, we report two cases of localized Sweet syndrome on the lymphedematous lower limbs: one occurred after radical hysterectomy, bilateral pelvic lymph node dissection and radiotherapy for cervical cancer...περισσότερα »
Photodynamic therapy as a therapeutic alternative in vulvar lichen sclerosus: series of 8 cases
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Lichen sclerosus (LS) is a chronic mucocutaneous inflammatory disease of progressive course, with a predilection for the anogenital region. Patients require clinical control every 6-12 months and treatment to avoid progression. Local hygiene measures and use of emollients is essential. High potency topical corticosteroids are the first-line treatment. The therapeutic response is often unsatisfactory and therapeutic alternatives are needed. The following measures have been tried: topical calcineurin inhibitors, UVA1 phototherapy, topical tretinoin, oral acitretin, oral cyc... περισσότερα »
Fructose consumption impairs serotonergic signaling in the murine enteric nervous system
Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Abstract The intake of free fructose has increased substantially since the development of high-fructose corn syrup. This has not only been associated with metabolic disorders but recent evidence also indicates that chronic fructose consumption can affect neuronal and cognitive function. In this study we investigated the effects of fructose consumption on serotonergic signaling and neuronal activity in the mouse submucous plexus. Male mice were put on a control or fructose (23% solution) diet for 6 weeks or were assigned to a recovery group that received normal water (2 weeks) after... περισσότερα »
Hepatitis C virus coinfection as a risk factor for osteoporosis and fracture
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Current Opinion in HIV and AIDS from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1SvjhUO via IFTTT
Clinical outcomes efficacy and adverse events in patients undergoing esophageal stent placement for benign indications: a large multicenter study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Clinical Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WHcKJV via IFTTT
Alcohol consumption and colon cancer prognosis among participants in North Central Cancer Treatment Group phase III trial N0147
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
International Journal of Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1SvjkQw via IFTTT
Differences in motor recovery between upper and lower limbs: does stroke subtype make the difference?.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Previous studies comparing the patterns of recovery for upper (UL) and lower limbs (LL) reported similar patterns of motor recovery of extremities. However, the influence of clinical stroke subtypes on the difference between recovery of extremities has never been investigated. The aim of this study is to compare the time course of the UL and LL in a sample of patients who have had distinct subtypes of ischemic stroke. A total of 443 consecutive patients following ischemic stroke were assessed at admission, discharge, and 1 month after discharge with the arm and leg motor parts of th... περισσότερα »
Antibodies Vol. 5 Pages 9: Autoantibodies in Neuropsychiatric Disorders
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Little is known about the etiology of neuropsychiatric disorders. The identification of autoantibodies targeting the N-methyl-d-aspartate receptor (NMDA-R), which causes neurological and psychiatric symptoms, has reinvigorated the hypothesis that other patient subgroups may also suffer from an underlying autoimmune condition. In recent years, a wide range of neuropsychiatric diseases and autoantibodies targeting ion-channels or neuronal […]
Cancer sufferer thankful for life-saving surgery – Cambrian News
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cancer sufferer thankful for life-saving surgery Cambrian News A BARMOUTH woman, who has twice faced cancer, has thanked surgeons for saving her life by rebuilding her neck. Care worker Lynn Morrisey now speaks with an electronic larynx after losing her voice box due to cancer of the throat and oesophagus. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis […]
Nedsatt følsomhet for thyreoideahormon
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dette kan skyldes ulike genetiske defekter og er sjeldent. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Vm8kbW via IFTTT
Keratitisichthyosisdeafness syndrome with recurrent pneumonia but no mucocutaneous infection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XJZgvb via IFTTT
Rituximab monotherapy to treat intravascular large B-cell lymphoma manifesting as pruritic calf patch in an elderly female
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/26gkVAS via IFTTT
Lymphedema-associated neutrophilic dermatosis: Two cases of localized Sweet syndrome on the lymphedematous lower limbs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Neutrophilic dermatosis on the site of lymphedema is a rare condition and considered as a localized and less severe variant of Sweet syndrome. Only 13 cases of this variant have been reported after mastectomy for breast cancer in the English-language published work. However, this condition has never been described on the lower limbs or […]
Impaired Ca 2 Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 2 ώρες
ABSTRACT We hypothesized that SIRS/endotoxemia-associated hyporesponsiveness to vasoconstrictors is mediated by smaller increases in intracellular Ca2+ levels due to reduced signaling via the STIM/Orai. Male Wistar rats were injected either with saline or bacterial LPS (i.p.; 10 mg/kg), and experiments were performed 24 h later. LPS-injected rats exhibited decreased systolic blood pressure, increased heart rate, neutrophils' migration into the peritoneal cavity, and elevated alanine aminotransferase levels. Additionally, second-order mesenteric arteries from endotoxemic rats displ... περισσότερα »
Roboterassistierte Haartransplantation
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 2 ώρες
Zusammenfassung Die roboterassistierte Haarwurzelentnahme (FUE) ist eine echte Neuerung und Bereicherung im Prozess der Eigenhaarwurzeltransplantation. Das ARTAS-Robotersystem arbeitet sicher und mit sehr geringer Verletzungsrate für die Haarwurzelschäfte. Die meisten FUE-Haarpatienten stehen dem System positiv und aufgeschlossen gegenüber. Der Roboter erfordert ein gut geschultes und erfahrenes Team, welches sich täglich ausschließlich mit Haartransplantationen beschäftigen sollte. Es bleibt abzuwarten, ob nach Vergleich mit entsprechend hohen Fallzahlen der Roboter dem erfahrene... περισσότερα »
The insights of Let-7 miRNAs in oncogenesis and stem cell potency
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 rese... περισσότερα »
hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract Mesenchymal stem cells (MSCs) are being assessed for ameliorating the severity of graft-versus-host disease, autoimmune conditions, musculoskeletal injuries and cardiovascular diseases. While most of these clinical therapeutic applications require substantial cell quantities, the number of MSCs that can be obtained initially from a single donor remains limited. The utility of MSCs derived from human-induced pluripotent stem cells (hiPSCs) has been shown in recent pre-clinical studies. Since adult MSCs have limited capability regarding proliferation, the quantum of bioacti... περισσότερα »
MicroRNA-224 regulates self-renewal of mouse spermatogonial stem cells via targeting DMRT1
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems, where their functions include the regulation of self-renewal, cellular differentiation, proliferation and apoptosis. However, the function and mechanisms of individual miRs in regulating spermatogonial stem cell (SSC) homeostasis remain unclear. In the present study, we report for the first time that miR-224 is highly expressed in mouse SSCs. Functional assays using miRNA mimics and inhibitors reveal that miR-224 is essential for differentiation of SSCs. Mechanistically, m... περισσότερα »
Renoprotective effect of berberine via regulating the PGE2-EP1-Gαq-Ca2 signalling pathway in glomerular mesangial cells of diabetic rats
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract G-protein coupled receptor-mediated pathogenesis is of great importance in the development of diabetic complications, but the detailed mechanisms have not yet been clarified. Therefore, we aimed to explore the roles of the prostaglandin E2 receptor 1 (EP1)-mediated signalling pathway and develop a corresponding treatment for diabetic nephropathy (DN). To create the DN model, rats fed a high-fat and high-glucose diet were injected with a single dose of streptozotocin (35 mg/kg, i.p.). Then, rats were either treated or not with berberine (100 mg/kg per day, i.g., 8 weeks). C...περισσότερα »
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell carcinoma. The patient underwent surgical r... περισσότερα »
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 2 ώρες
The aim of this study was to investigate the clinical features and prognosis of patients with squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (IP). (Source: Auris, Nasus, Larynx) from squamous cell carcinoma via ok on Inoreader http://ift.tt/1MJVL7x via IFTTT
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