Head and Neck Medicine by Alexandros G.Sfakianakis: OtoRhinoLaryngology & Medicine,New Articles,April 26th,2016,a

Τρίτη 26 Απριλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,April 26th,2016,a

Human psychology: Why do we have equivalents of bogeyman in so many countries around the world?

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα

Bogeyman (also spelled bogieman, boogeyman, or boogie man) is a common allusion to a mythical creature in many cultures used by adults to frighten children into good behavior. This monster has no specific appearance, and conceptions about it can vary drastically from household to household within the same community. Parents may tell their children that […]

The Clinical Clues of Pulmonary Alveolar Proteinosis: A Report of 11 Cases and Literature Review

Pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterized by the abnormal alveolar accumulation of surfactant components. The diagnosis of PAP can be easily missed since it is rare and lacks specific clinical symptoms. It is of great importance to have a better understanding of the crucial clue to clinically diagnose PAP and […]

Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals

This study investigated for the first time the genomewide DNA methylation changes of noncoding RNA genes in the temporal cortex samples from individuals with Alzheimer’s disease (AD). The methylome of 10 AD individuals and 10 age-matched controls were obtained using Illumina 450 K methylation array. A total of 2,095 among the 15,258 interrogated noncoding RNA CpG […]

A Unified Factors Analysis Framework for Discriminative Feature Extraction and Object Recognition

Various methods for feature extraction and dimensionality reduction have been proposed in recent decades, including supervised and unsupervised methods and linear and nonlinear methods. Despite the different motivations of these methods, we present in this paper a general formulation known as factor analysis to unify them within a common framework. During factor analysis, an object […]

Hypothyroid Myopathy after Radioactive Iodine Therapy for Graves’ Disease: A Case Report

The post Hypothyroid Myopathy after Radioactive Iodine Therapy for Graves’ Disease: A Case Report appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UepiYG via IFTTT

IJMS, Vol. 17, Pages 623: Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off

The circadian biological clock is essentially based on the light/dark cycle. Some people working with shift schedules cannot adjust their sleep/wake cycle to the light/dark cycle, and this may result in alterations of the circadian biological clock. This study explored the circadian biological clock of shift and daytime nurses using non-invasive methods. Peripheral skin temperature, […]

Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting: Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor concentrations to achieve hemostasis, but like with all procoagulants, the effect is balanced against thromboembolic risk. The latter is dependent on both the dose of PCCs and the individual patient prothrombotic predisposition. PCCs are approved by the US Fo... περισσότερα »

High Glucose Attenuates Anesthetic Cardioprotection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

in Stem-Cell–Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission: BACKGROUND: Hyperglycemia can blunt the cardioprotective effects of isoflurane in the setting of ischemia–reperfusion injury. Previous studies suggest that reactive oxygen species (ROS) and increased mitochondrial fission play a role in cardiomyocyte death during ischemia–reperfusion injury. To investigate the role of glucose concentration in ROS production and mitochondrial fission during ischemia–reperfusion (with and without anesthetic protection), we used the novel platform of hu... περισσότερα »

In the Aftermath

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Attitudes of Anesthesiologists to Supportive Strategies After an Unexpected Intraoperative Patient Death: BACKGROUND: Although most anesthesiologists will have 1 catastrophic perioperative event or more during their careers, there has been little research on their attitudes to assistive strategies after the event. There are wide-ranging emotional consequences for anesthesiologists involved in an unexpected intraoperative patient death, particularly if the anesthesiologist made an error. We used a between-groups survey study design to ask whether there are different attitudes to ass... περισσότερα »

Perioperative Respiratory Adverse Events in Pediatric Ambulatory Anesthesia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

: Development and Validation of a Risk Prediction Tool: BACKGROUND: Perioperative respiratory adverse events (PRAEs) are the most common cause of serious adverse events in children receiving anesthesia. Our primary aim of this study was to develop and validate a risk prediction tool for the occurrence of PRAE from the onset of anesthesia induction until discharge from the postanesthesia care unit in children younger than 18 years undergoing elective ambulatory anesthesia for surgery and radiology. The incidence of PRAE was studied. METHODS: We analyzed data from 19,059 patients fro...περισσότερα »

Human CD8+ T cells transduced with an additional receptor bispecific for both Mycobacterium tuberculosis and HIV-1 recognize both epitopes

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα

Abstract Tuberculosis (TB) and human immunodeficiency virus type 1 (HIV-1) infection are closely intertwined, with one-quarter of TB/HIV coinfected deaths among people died of TB. Effector CD8+ T cells play a crucial role in the control of *Mycobacterium tuberculosis* (MTB) and HIV-1 infection in coinfected patients. Adoptive transfer of a multitude of effector CD8+ T cells is an appealing strategy to impose improved anti-MTB/HIV-1 activity onto coinfected individuals. Due to extensive existence of heterologous immunity, that is, T cells cross-reactive with peptides encoded by rela... περισσότερα »

Vaccine-preventable diseases (VPDs) such as measles and pertussis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications: Vaccine-preventable diseases (VPDs) such as measles and pertussis are becoming more common in the United States. This disturbing trend is driven by several factors, including the antivaccination movement, waning efficacy of certain vaccines, pathogen adaptation, and travel of individuals to and from areas where disease is endemic. The anesthesia-related manifestations of many VPDs involve airway complications, cardiovascular and respiratory compromise, and unusual neurologic ... περισσότερα »

Maximal Safe Dosages of Tumescent Lidocaine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

Estimated BACKGROUND: Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after subcutaneous administration of tumescent lidocaine with and without liposuction. Our hypotheses were that even with large doses (i.e., >30 mg/kg), serum lidocaine concentrations ...περισσότερα »

The Explorer Endoscopy Mask© for esogastroduodenoscopy in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

a retrospective study of 173 cases: Summary Aims The aim of this study was to evaluate the usability and safety of the Explorer Endoscopy Mask® (EM) as an alternative to endotracheal intubation in children undergoing elective esogastroduodenoscopy (EGD) under general anesthesia (GA). Methods This study was a retrospective observational study. The study was undertaken at the pediatric digestive endoscopy suite in the Cliniques universitaires Saint-Luc, Brussels, Belgium. We retrospectively analyzed the occurrence of minor and major airway-related adverse effects during pediatric EGD... περισσότερα »

Utility of screening questionnaire, obesity, neck circumference, and sleep polysomnography

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

to predict sleep-disordered breathing in children and adolescents: Summary Background Polysomnography (PSG) remains the gold standard for diagnosing obstructive sleep apnea (OSA) and sleep-disordered breathing in children. Yet, simple screening tools are needed as it is not feasible to perform PSG in all patients with possible OSA. Aim The study adapted questions from the Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder (SRBD) Questionnaire to develop a predictive scale for OSA identified on PSG. We also tested whether adding anthropometric measurements (body mass ind...περισσότερα »

Pulse Spectroscopy for Detecting Hypoxemia and Coexisting Methemoglobin or Carboxyhemoglobin.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

The Accuracy of BACKGROUND: Pulse spectroscopy is a new noninvasive technology involving hundreds of wavelengths of visible and infrared light, enabling the simultaneous quantitation of multiple types of normal and dysfunctional hemoglobin. We evaluated the accuracy of a first-generation pulse spectroscopy system (V-Spec(TM) Monitoring System, Senspec, Germany) in measuring oxygen saturation (SpO2) and detecting carboxyhemoglobin (COHb) or methemoglobin (MetHb), alone or simultaneously, with hypoxemia. METHODS: Nineteen volunteers were fitted with V-Spec probes on the forehead a... περισσότερα »

Flexible Epidural Catheters Under Various Conditions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Comparison of Changes in Tensile Strength in 3 Different BACKGROUND: Rarely, epidural catheters may fracture upon removal or insertion. Understanding some of the mechanical properties of epidural catheters, such as their tensile strength and how external factors (including temperature) can influence their strength, will aid physicians in making decisions if faced with an entrapped catheter. In the present study, we evaluated the impact in tensile strength when catheters are exposed to 37 +/- 1[degrees]C, after the removal of the inner metal coil and after the injection of sterile... περισσότερα »

The Airtraq(®) NT, McGrath(®) MAC and Macintosh laryngoscopes for nasotracheal intubation of simulated easy and difficult airways

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

A randomised crossover trial comparing the Airtraq(®) NT, McGrath(®) MAC and Macintosh laryngoscopes for nasotracheal intubation of simulated easy and difficult airways in a manikin.: Braz J Anesthesiol. 2016 May-Jun;66(3):289-97 Authors: Gómez-Ríos MÁ, Pinegger S, de Carrillo Mantilla M, Vizcaino L, Barreto-Calvo P, Paech MJ, Gómez-Ríos D, López-Calviño B Abstract OBJECTIVE: Several devices can aid nasotracheal intubation when managing difficult airways. The McGrath MAC and Airtraq NT were compared with a Macintosh laryngoscope when studying the performance of anaesthetists with ...περισσότερα »

Primary Immune Deficiency Treatment Consortium (PIDTC)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Update via Allergy and Clinical Immunology Publication date: Available online 22 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Linda M. Griffith, Morton J. Cowan, Luigi D. Notarangelo, Donald B. Kohn, Jennifer M. Puck, William T. Shearer, Lauri M. Burroughs, Troy R. Torgerson, Hélène Decaluwe, Elie Haddad The Primary Immune Deficiency Treatment Consortium (PIDTC) is a collaboration of 41 North American centers studying therapy for rare primary immune deficiency diseases (PID) including Severe Combined Immune Deficiency (SCID), Wiskott-Aldrich syndrome (WAS)...περισσότερα »

Respiratory Syncytial Virus Immunoprophylaxis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

in High-Risk Infants and Development of Childhood Asthma via Allergy and Clinical Immunology Publication date: Available online 21 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Kecia N. Carroll, Tebeb Gebretsadik, Gabriel J. Escobar, Pingsheng Wu, Sherian Xu Li, Eileen M. Walsh, Ed Mitchel, Chantel D. Sloan, William D. Dupont, Tina V. Hartert BackgroundRespiratory syncytial virus (RSV) lower respiratory tract infection is implicated in asthma development. RSV immunoprophylaxis during infancy is efficacious in preventing RSV hospitalizations and has been ass...περισσότερα »

Use of dry-moist heat effects to improve the functionality, immunogenicity of whole wheat flour

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

and its application in bread making via ScienceDirect Search: baker’s asthma Publication date: Available online 21 April 2016 *Source:*Journal of Cereal Science Author(s): M.L. Sudha, C. Soumya, P. Prabhasankar Whole wheat flour samples having protein content of 8.9% and 10.6% were subjected to dry and moist heat conditions to improve the functionality. Dry heat treated flours (DHTF) had higher values of falling number and SDS sedimentation values when compared to moist heat treated flour (MHTF). MHTF showed decrease in water absorption from 75.4 to 56.7%, increase in dough developmen...περισσότερα »

Serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Utility of Abstract Background Omalizumab, a humanised anti-IgE monoclonal antibody, has demonstrated efficacy in patients with severe allergic asthma. However, treatment responses vary widely among individuals. Despite a lack of data, free serum IgE levels following omalizumab treatment have been proposed as a marker of treatment responsiveness. Methods In this prospective, observational study, we assessed the utility of biomarkers of type 2 inflammation in predicting omalizumab treatment responses, as determined by the absence of asthma exacerbation during the first year of tre...περισσότερα »

Genetics of Hereditary Angioedema

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Revisited: AbstractContemporary genetic research has provided evidences that angioedema represents a diverse family of disorders related to kinin metabolism, with a much greater genetic complexity than was initially considered. Convincing data have also recently been published indicating that the clinical heterogeneity of hereditary angioedema due to C1 inhibitor deficiency (classified as C1-INH-HAE) could be attributed at least in part, either to the type of *SERPING1* mutations or to mutations in genes encoding for enzymes involved in the metabolism and function of bradykinin. ... περισσότερα »

Angioedema Phenotypes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

: Disease Expression and Classification: AbstractDue to marked heterogeneity of clinical presentations, comprehensive knowledge of angioedema phenotypes is crucial for correct diagnosis and choosing the appropriate therapeutic approach. One of the ways to a meaningful clinical distinction can be made between forms of angioedema occurring “with or without wheals.” Angioedema with wheals (rash) is a hallmark of urticaria, either acute or chronic, spontaneous or inducible. Angioedema without wheals may still be manifested in about 10 % of patients with urticaria, but it may also occur...περισσότερα »

Nasal appearance after secondary cleft rhinoplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

: comparison of professional rating with patient satisfaction via Oral and Maxillofacial Surgery AbstractObjectiveThe purpose of this study was to compare professional rating and patient satisfaction of nasal appearance after secondary cleft rhinoplasty. MethodWe used a cross-sectional study design and enrolled German adults with nonsyndromic unilateral or bilateral cleft lip and/or palate (UCLP and BCLP, respectively) undergoing secondary cleft rhinoplasty from January 2001 to December 2013. The predictor variable was professional rating. The outcome variable was patient satisfaction...περισσότερα »

The genetic ancestry of patients with oral clefts

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations by Camilla D. Vieira-Machado, Flavia M. Carvalho, Luiz C. Silva, Sidney E. Santos, Claudia Martins, Fernando A. Poletta, Juan C. Mereb, Alexandre R. Vieira, Eduardo E. Castilla, Iêda M. Orioli via European Journal of Oral Sciences Increased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this... περισσότερα »

Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Morbidity and Mortality Rates after via Oral and Maxillofacial Surgery Publication date: Available online 21 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Luis A. Passeri, James G. Choi, Leonard B. Kaban, Edward T. Lahey PurposeTo compare morbidity and mortality rates in obstructive sleep apnea (OSA) versus dentofacial deformity (DFD) patients undergoing equivalent maxillofacial surgical procedures.Patients and MethodsPatients with OSA who underwent maxillomandibular advancement with genial advancement (MMA), at Massachusetts General Hospital Department of Or... περισσότερα »

Oropharyngeal injury with the use of video laryngoscopy techniques

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Report of two cases of via Oral and Maxillofacial Surgery Publication date: Available online 23 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Bradford Huffman, Suvikram Puri, Henry Heyman, Vikas Kumar, Solon Kao While the trend toward video laryngoscopy and away from direct laryngoscopy may be associated with a greater likelihood of successful intubation, appropriate training is necessary to prevent injuries. We present two instances of operator error which resulted in penetrating injury to the soft palate as well as a review of the literature.

Piezotome-Rhinoplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

reduces post-surgical morbidity and enhances patient satisfaction: a multidisciplinary clinical study via Oral and Maxillofacial Surgery Publication date: Available online 23 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Troedhan Angelo PurposeExperimental and clinical studies in various fields of oral and maxillofacial surgery suggest the use of piezotomes to reduce post-surgical morbidity and enhance healing. The aim of the study was to investigate if rhinoplasty-surgery with piezotomes might decrease post-surgical morbidity and increase overall patient sa... περισσότερα »

Vascular Anastomosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Clinical Application of an Original Vascular Anastomosis: a Clinical Multicenter Study via Oral and Maxillofacial Surgery Publication date: Available online 25 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Zhen-Hu Ren, Han Jiang Wu, Tong Ji, Kai Wang, Sandhya Gokavarapu, Chen-Ping Zhang PurposeVascular anastomosis is the most important technical step required for the possibility of free tissue transfer; and the mismatch of the donor and recipient vessel size is most common surgical challenge. As recent reports have described a new method (Ren’s anastomosis) t...περισσότερα »

Nerve sharing between the lingual and mental nerve to restore lower lip sensation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

after segmental resection of the mandible via Oral and Maxillofacial Surgery Publication date: Available online 25 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Takuya Murata, Harutsugi Abukawa, Takafumi Satomi, Daichi Chikazu This report demonstrates a successful new procedure for reconstructing the inferior alveolar nerve (IAN) by transplanting the great auricular nerve (GAN) between the mental nerve and the remaining submandibular ganglion (SG) to achieve nerve sharing of the lingual nerve. A 59-year-old woman with discomfort in the left mandibular retromo...περισσότερα »

Guided bone regeneration with mineralized allograft : Treatment of labial soft tissue recession around dental implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

in the esthetic zone using guided bone regeneration with mineralized allograft: a retrospective clinical case series via Oral and Maxillofacial Surgery Publication date: Available online 25 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Bach Le, Ali Borzabadi-Farahani, Brady Nielsen ObjectivesSoft tissue augmentation procedures are often performed to correct gingival recesson on the facial aspects of implants in the esthetic zone. This retrospective clinical case series reports on the use of guided bone regeneration (GBR) and coronal advancement flap with reso... περισσότερα »

Premalignant lesions of the esophagus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Current status of management of malignant disease: what are the options for premalignant lesions of the esophagus and stomach?: [image: http:--production.springer.de-OnlineReso] Authors: Marks JM, King AJ Abstract INTRODUCTION: Premalignant lesions of the foregut (esophagus and stomach) are common entities usually incidentally identified on either endoscopic or radiographic imaging studies. SYMPTOMS: These lesions are often asymptomatic or associated with vague gastrointestinal symptoms. TREATMENT: Current management of benign and premalignant lesions of the foregut includes pri... περισσότερα »

Cytogenetic damage of radiotherapy in long-term head and neck cancer survivors

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

10.1080/09553002.2016.1175680 Dilek Unal from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1NOBhFw via IFTTT

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

via the LKB1 pathway.: Oncol Rep. 2016 Apr 19; Authors: Lu C, Xie C Abstract Radiotherapy is an important treatment modality for esophageal cancer; however, the clinical efficacy of radiotherapy is limited by tumor radioresistance. In the present study, we explored the hypothesis that radiation induces tumor cell autophagy as a cytoprotective adaptive response, which depends on liver kinase B1 (LKB1) also known as serine/threonine kinase 11 (STK11). Radiation-induced Eca-109 cell autophagy was found to be dependent on signaling through the LKB1 pathway, and autophagy inhibitors ...περισσότερα »

The impact of eating disorders on the condition of the vocal apparatus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

The assessment of the impact of anorexia nervosa on the vocal apparatus in adolescent girls – A preliminary report via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Barbara Maciejewska, Aleksandra Rajewska-Rager, Zofia Maciejewska-Szaniec, Michał Michalak, Andrzej Rajewski, Bożena Wiskirska-Woźnica BackgroundChronic undernourishment in the course of anorexia nervosa leads to various metabolic and hormonal changes, which translates to the impaired functioning of the...περισσότερα »

Orbital complications associated with paranasal sinus infections

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

– A 10-year experience in Israel via International Journal of Pediatric Otorhinolaryngology Publication date: July 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 86 Author(s): Nili Segal, Roni Nissani, Sofia Kordeluk, Meni Holcberg, Shay Hertz, Firas Kassem, Anwar Mansour, Avichai Segal, Ofer Gluck, Yehudah Roth, Tal Honigman, Moshe Ephros, Ranan Cohen Kerem ObjectiveOrbital involvement is the most common complication of sinus infections. The epidemiology of the disease is continuously changing in the antibiotic era.Materials and methodsData on patients wh... περισσότερα »

Methotrexate-induced Gastrointestinal Mucositis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Effect of Oral Insulin on the Severity and Recovery of Methotrexate-induced Gastrointestinal Mucositis in the Rat.: J Pediatr Gastroenterol Nutr. 2016 Apr 21; Authors: Kuiken NS, Rings EH, Havinga R, van der Aa SA, Groen AK, Tissing WJ Abstract OBJECTIVES: Gastrointestinal (GI) mucositis is a severe side effect of chemo- and radiotherapy. Oral insulin has been suggested as possible intestinal growth factor and possible intervention for GI mucositis. We aimed to determine the effect of oral insulin on the severity and recovery of mucositis in a methotrexate (MTX)-induced GI mucositi... περισσότερα »

Multi-band mucosectomy versus endoscopic submucosal dissection for the treatment of squamous intraepithelial neoplasia of the esophagus.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Multi-band mucosectomy versus endoscopic submucosal dissection for the treatment of squamous intraepithelial neoplasia of the esophagus.* Clin Gastroenterol Hepatol. 2016 Apr 19; Authors: Jin XF, Chai TH, Gai W, Chen ZS, Guo JQ Abstract OBJECTIVE: This study aims to compare the efficacy and safety of multi-band mucosectomy (MBM) versus endoscopic submucosal dissection (ESD) for treating squamous intraepithelial neoplasia of the esophagus. METHODS: A total of 78 patients with squamous intraepithelial neoplasia of the esophagus who received either ESD or MBM were included in this r...περισσότερα »

Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells.* Oncol Rep. 2016 Apr 5; Authors: Lei Y, Zhen Y, Zhang W, Sun X, Lin X, Feng J, Luo H, Chen Z, Su C, Zeng B, Chen J Abstract Hydrogen sulfide (H2S) participates in diverse physiological and pathophysiologic processes of cancer both in vitro and in vivo. We have previously reported the proliferation/anti-apoptosis/angiogenesis/migration effects of exogenous H2S on liver cancer and glioma via amplifying the activation of NF-κB and p38 MAP... περισσότερα »

Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1.* Oncol Rep. 2016 Apr 13; Authors: Yang XX, Sang MX, Zhu SC, Liu ZK, Ma M Abstract Radiotherapy (RT) has been widely used to treat cancer patients, particularly esophageal cancer patients. B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) plays an important role in promoting the growth of cancer cells after exposure to irradiation. The present study aimed to characterize the effects of BMI-1 on the proliferation and invasion of cancer cells, as well as the mechanism involved in the... περισσότερα »

Current status of management of malignant disease: what are the options for premalignant lesions of the esophagus and stomach?

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

[image: http:--production.springer.de-OnlineReso] Related Articles *Current status of management of malignant disease: what are the options for premalignant lesions of the esophagus and stomach?* J Gastrointest Surg. 2015 Mar;19(3):575-8 Authors: Marks JM, King AJ Abstract INTRODUCTION: Premalignant lesions of the foregut (esophagus and stomach) are common entities usually incidentally identified on either endoscopic or radiographic imaging studies. SYMPTOMS: These lesions are often asymptomatic or associated with vague gastrointestinal symptoms. TREATMENT: Current management of b...περισσότερα »

Dose escalation study of proton beam therapy with concurrent chemotherapy for stage III non-small cell lung cancer.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Dose escalation study of proton beam therapy with concurrent chemotherapy for stage III non-small cell lung cancer.* Cancer Sci. 2016 Apr 25; Authors: Harada H, Fuji H, Ono A, Kenmotsu H, Naito T, Yamashita H, Asakura H, Nishimura T, Takahashi T, Murayama S Abstract The purpose of this study is to determine the recommended dose (RD) of proton beam therapy (PBT) for inoperable stage III non-small cell lung cancer (NSCLC). We tested two prescribed doses of PBT;66 Gy (relative biological effectiveness; RBE) in 33 fractions and 74 Gy (RBE) in 37 fractions in arms 1 and 2, respective...περισσότερα »

The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.* Clin Epigenetics. 2016;8:43 Authors: Ma K, Cao B, Guo M Abstract Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smoking and alcohol consumption are two major risk factors for ESCC, and both tobacco and al... περισσότερα »

Comprehensive Registry of Esophageal Cancer in Japan, 2009.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Comprehensive Registry of Esophageal Cancer in Japan, 2009.* Esophagus. 2016;13:110-137 Authors: Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, Matsubara H, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, Registration Committee for Esophageal Cancer of the Japan Esophageal Society PMID: 27110229 [PubMed - as supplied by publisher] from pubmed: esophageal cancer http://ift.tt/1SGZXUJ via IFTTT

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway.* Oncol Rep. 2016 Apr 19; Authors: Lu C, Xie C Abstract Radiotherapy is an important treatment modality for esophageal cancer; however, the clinical efficacy of radiotherapy is limited by tumor radioresistance. In the present study, we explored the hypothesis that radiation induces tumor cell autophagy as a cytoprotective adaptive response, which depends on liver kinase B1 (LKB1) also known as serine/threonine kinase 11 (STK11). Radiation-induced Eca-109 cell autophagy was...περισσότερα »

Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1.* Oncol Rep. 2016 Apr 4; Authors: Luo J, Zhang C, Wang C, Li L, Li C, Li Q, Zhang M, Wu Q Abstract Tumorigenesis results from various types of dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis and senescence. The transcription factor Myc-interacting zinc finger protein 1 (Miz-1) can either activate or repress gene expression in concert with binding partners including the Myc oncoprotein in several... περισσότερα »

Oxidative stress from reflux esophagitis to esophageal cancer; the alleviation with antioxidants.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 22 δευτερόλεπτα

*Oxidative stress from reflux esophagitis to esophageal cancer; the alleviation with antioxidants.* Free Radic Res. 2016 Apr 25;:1-20 Authors: Song JH, Han YM, Kim WH, Park JM, Jeong M, Go EJ, Hong SP, Hahm KB Abstract The incidence of reflux esophagitis increases in world, affecting approximately 20% of western populations and its consequent lesion, Barrett's esophagus (BE), established as the primary precursor lesion of esophageal adenocarcinoma (EAC) or Barrett associated adenocarcinoma (BAA), is also increasing in incidence in Asian countries as well as Western countries. The...περισσότερα »

Characterization of Leptospiral Chemoreceptors Using a Microscopic Agar Drop Assay.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 22 δευτερόλεπτα

*Characterization of Leptospiral Chemoreceptors Using a Microscopic Agar Drop Assay.* Curr Microbiol. 2016 Apr 25; Authors: Affroze S, Islam MS, Takabe K, Kudo S, Nakamura S Abstract Bacterial chemotaxis is induced by sensing chemical stimuli via chemoreceptors embedded in the cytoplasmic membrane, enabling the cells to migrate toward nutrients or away from toxins. The chemoreceptors of Escherichia coli and Salmonella spp. have been well studied and are functionally classified on the basis of detectable substrates. The spirochete Leptospira possesses more than ten chemoreceptors ... περισσότερα »

Characterization of Leptospiral Chemoreceptors Using a Microscopic Agar Drop Assay.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 22 δευτερόλεπτα

Characterization of Leptospiral Chemoreceptors Using a Microscopic Agar Drop Assay.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 22 δευτερόλεπτα

Characterization of Leptospiral Chemoreceptors Using a Microscopic Agar Drop Assay.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 22 δευτερόλεπτα

The contralateral tonsil following unilateral tonsillectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα

PET/CT findings within Objectives/Hypothesis In the setting of considerable variation of pharyngeal palatine tonsil fluorine 18 fluorodeoxyglucose (FDG) uptake, we mostly rely on the asymmetry between the left- and right-sided tonsils to identify underlying malignancy. The current study evaluates the FDG positron emission tomography (PET)/computed tomography (CT) findings within the contralateral tonsil among patients who had unilateral tonsillectomy and analyzes the cancer incidence in the contralateral tonsil with high FDG avidity. Study Design A retrospective cohort study in ... περισσότερα »

Arytenoid adduction combined with nerve-muscle pedicle flap implantation or type I thyroplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα

Arytenoid adduction combined with nerve-muscle pedicle flap implantation or type I thyroplasty: Objectives/Hypothesis To evaluate vocal function after refined nerve-muscle pedicle (NMP) flap implantation with arytenoid adduction (AA) compared with type I thyroplasty with AA for patients with unilateral vocal fold paralysis (UVFP) and to evaluate the degree of patient satisfaction following the refined NMP with AA. Study Design A retrospective review of clinical records of 52 patients with UVFP who received AA + NMP (NMP group, n = 40) or AA + type I thyroplasty (type I group, n... περισσότερα »

Industry financial ties

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

Are industry financial ties associated with greater scholarly impact among academic otolaryngologists?: Objectives/Hypothesis In response to concerns regarding physician–industry relationships, the Physician Sunshine Act of 2010 was passed in an effort to increase transparency and accountability. Our objective was to determine whether there is an association between industry support and scholarly impact among academic otolaryngologists. Methods Faculty listings, academic rank, and fellowship training of academic otolaryngologists were accessed from departmental websites. *H-indi...περισσότερα »

Granulomatosis with polyangiitis (Wegener's Granulomatosis) in the pediatric airway

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

The presentation and management of Objective Granulomatosis with polyangiitis (GPA) is a necrotizing inflammatory disease that can affect the airway. The purpose of this study was to present a case of pediatric laryngotracheal GPA and provide management recommendations based on a thorough review of the literature. Data Sources Retrospective chart and literature review Review Methods A pediatric patient with laryngotracheal and pulmonary manifestations of GPA who underwent chemotherapy and intralesional corticosteroid injection is described. An extensive literature review of pediatr...περισσότερα »

Recalcitrant idiopathic epistaxis in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

Outcomes of recalcitrant idiopathic epistaxis in children: Septoplasty as a surgical treatment: Our objective was to measure short- and long-term outcomes of children presenting with recalcitrant idiopathic epistaxis. The study was an 11-year (2000–2011) retrospective chart review of children evaluated and treated for epistaxis. A retrospective review of patients with diagnostic International Classification of Diseases, Ninth Revision code 784.7 (epistaxis) and 21.5/21.88 (septoplasty) was completed reviewing age at presentation, type of surgery, and number of bleeding events p... περισσότερα »

Head and neck Epstein-Barr virus mucocutaneous ulcer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Case report and literature review: Objectives/Hypothesis To report the clinical presentation, treatment, and management outcomes of patients with Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) of the head and neck, which is a newly characterized pathologic entity with aggressive morphology but follows an indolent, self-limiting clinical course. Study Design Case report and literature review. Methods A case of EBVMCU of the base of tongue is reported and a retrospective review of all cases of EBVMCU of the head and neck at a single academic institution was conducted bet... περισσότερα »

Posterior cricoarytenoid muscle electrophysiologic changes are predictive

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

of vocal cord paralysis with recurrent laryngeal nerve compressive injury in a canine model: Objectives/Hypothesis Injury to the recurrent laryngeal nerve (RLN) is a dreaded complication of endocrine surgery. Intraoperative neural monitoring (IONM) has been increasingly utilized to assess the functional status of the RLN. Although the posterior cricoarytenoid muscle (PCA) is innervated by the RLN as the abductor of the larynx, PCA electromyography (EMG) is infrequently recorded during IONM and PCA activity after RLN compressive injury remains poorly characterized. Study Design Sin... περισσότερα »

Office-based biopsies for laryngeal lesions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Analysis of consecutive 581 cases: Objectives/Hypothesis Office-based biopsy (OBB) is widely used to diagnose suspicious laryngeal lesions. However, its routine use is still controversial and the algorithm for clinical strategy is not concrete. We tried to evaluate the accuracy of OBB as a diagnostic tool for laryngeal malignancy. Methods Medical data of 581 patients undergoing OBB were reviewed. Diagnostic values of OBB were analyzed for malignancy and malignancy/premalignancy. False negative rates (FNRs) were analyzed according to subsites, lesion sizes, and morphology. Resul... περισσότερα »

Frozen section in head and neck squamous cell carcinoma resection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Refining the utility and role of Objectives/Hypothesis Previous studies report high-accuracy rates for intraoperative frozen sections, but reliability of frozen sections in predicting the ultimate final margin status is unknown. We compared frozen and permanent reads to identify risk factors for overall discrepancies between intraoperative and final margin status. Study Design Retrospective chart review. Methods Pathology reports of 437 surgical resections between 2010 and 2013 were retrospectively reviewed. A total of 253 cases, generating 1,109 individual specimens, met inclu... περισσότερα »

The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

A systematic review: Objectives/Hypothesis Antireflux therapy is incorporated in many treatment protocols for recurrent respiratory papillomatosis (RRP) because gastroesophageal reflux (GERD) is thought to worsen the disease course of RRP. It is unclear if GERD really aggravates the disease course. The aims of this systematic review were to 1) evaluate incidence of GERD among RRP patients and 2) report if GERD changes the clinical course or tissue properties of RRP. Study Design A search was conducted in PubMed, Embase, and Google Scholar, following the methods of Preferred Report...περισσότερα »