Head and Neck Medicine by Alexandros G.Sfakianakis: OtoRhinoLaryngology & Medicine,New Articles,April 26th,2016

Δευτέρα 25 Απριλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,April 26th,2016

The severity of atopic dermatitis evaluated with the SCORAD index

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

and the occurrence of bronchial asthma and rhinitis, and the duration of atopic dermatitis: This article is currently available as a free download on Ingenta Connect Abstract:Background and Objective: The aim of this study was an evaluation of the dependence between the severity of atopic dermatitis evaluated with the Scoring Atopic Dermatitis (SCORAD) index and the occurrence of other atopic diseases and parameters. Methods: The complete dermatological and allergological examinations were performed. The statistical evaluation of the dependence between the occurrence of bro... περισσότερα »

Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 δευτερόλεπτα

[image: cover.gif?v=1&s=4b6dd66353c9f7aa2f0e6e94] Summary More than 1,200 mutations in neuronal voltage-gated sodium channel (VGSC) genes have been identified in patients with several epilepsy syndromes. A common feature of genetic epilepsies is variable expressivity among individuals with the same mutation. The *Scn2a*Q54 transgenic mouse model has a mutation in *Scn2a* that results in spontaneous epilepsy. *Scn2a*Q54 phenotype severity varies depending on the genetic strain background, making it a useful model for identifying and characterizing epilepsy modifier genes. *Scn2a*Q... περισσότερα »

EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 δευτερόλεπτα

[image: cover.gif?v=1&s=4b6dd66353c9f7aa2f0e6e94] Summary Objective Rapid eye movement (REM) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission. We investigated whether interictal epileptiform discharges (IEDs) and high frequency oscillations—a biomarker of the epileptogenic zone—are evenly distributed across phasic and tonic REM sleep. We hypothesized that IEDs are more suppressed during phasic REM sleep because of additional cholinergic drive. Methods Twelve patie... περισσότερα »

Avascular necrosis after oral corticosteroids

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

in otolaryngology: Case report and review of the literature: This article is currently available as a free download on Ingenta Connect Abstract:Objective: In this report, we present a rare case of avascular necrosis (AVN) in an otherwise healthy 42-year-old male patient treated with low dose oral corticosteroids for his bronchitis. A systematic review of the literature related to AVN and corticosteroids was performed. Case Report: Forty-two-year-old male with no underlying conditions predisposing him to AVN who had been treated four years before for chronic bronchitis with t... περισσότερα »

Sarcoidosis with nasal bone involvement

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

A rare presentation of Abstract:Background: Sarcoidosis is a multisystem granulomatous inflammatory disease that is induced by infectious or noninfectious environmental antigens in a genetically susceptible host. Tuberculosis and sarcoidosis are two diseases with similar clinical and pathologic findings. The link between these two diseases has been extensively studied. Objective: Herein we describe a case of sarcoidosis associated with tuberculosis, treated for tuberculosis, and, 1 year, later presented with a nasal dorsal lump and skin lesions on the extremities. Methods...περισσότερα »

Hyperimmunoglobulin E syndrome (HIES) : Idiopathic pancreatitis in a patient with a STAT3 mutation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

Idiopathic pancreatitis in a patient with a STAT3 mutation: This article is currently available as a free download on Ingenta Connect Abstract:Background: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency characterized by recurrent skin infections with abscesses, recurrent pneumonias with pneumatoceles, and immunoglobulin E levels of >10 times the upper limit of normal. Case: The patient described herein had a classic case of signal transducer and activator of transcription 3 (STAT3) deficiency associated with HIES diagnosed several years before this p... περισσότερα »

Newborn nasal obstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

due to congenital nasal pyriform aperture stenosis: This article is currently available as a free download on Ingenta Connect Abstract:Introduction: Nasal obstruction is an important condition that can lead to severe respiratory distress in newborns. There are several differential diagnoses, and one of them is congenital nasal pyriform aperture stenosis (CNPAS). CNPAS is a rare case of respiratory distress caused by excessive growth of the nasal process of the maxilla and leads to narrowing of the anterior third of the nasal cavity. Diagnosis, associated anomalies, and treatmen... περισσότερα »

Metastatic mammary carcinoma to the orbit masquerading as maxillary sinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

Abstract:Introduction: We report on a case of isolated metastatic breast cancer to the medial rectus muscle. This entity is exceedingly rare. Case: A 44-year-old female with a history of breast cancer presented with unilateral maxillary symptoms and was treated for sinusitis. Over time, she developed ocular pain, diplopia, blurred vision and eventually complete adduction deficit. Results: T1-weighted magnetic resonance imaging revealed a medial rectus lesion. Biopsy via transnasal transorbital endoscopic approach revealed metastatic mammary carcinoma. Discussion: Metastat... περισσότερα »

Potassium titanyl phosphate laser turbinate reduction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

in the management of allergic inferior turbinate hypertrophy: Our experience: This article is currently available as a free download on Ingenta Connect Abstract:Background: Allergic inferior turbinate hypertrophy is one of the most common causes of nasal obstruction. Several surgical methods can be used for the reduction of allergic inferior turbinate hypertrophy refractory to medical management. Herein, we share our experience with a potassium titanyl phosphate (KTP) laser, which is a relatively novel technique for turbinate reduction. Objectives: To evaluate the efficacy... περισσότερα »

Oral mucosal immunotherapy for allergic rhinitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

A pilot study: This article is currently available as a free download on Ingenta Connect Abstract:Background: The sublingual mucosa has been used for many years to apply allergenic extracts for the purpose of specific immunotherapy (IT). Although sublingual IT (SLIT) is both safe and efficacious, the density of antigen-presenting cells is higher in other regions of the oral cavity and vestibule, which make them a potentially desirable target for IT. Objective: To present the concept of oral mucosal IT (OMIT) and to provide pilot data for this extended application of SLIT. ... περισσότερα »

Heat shock protein 70 and anti‐heat shock protein 70 antibodies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

in nasal secretions of patients with chronic rhinosinusitis: This article is currently available as a free download on Ingenta Connect Abstract:Background: The issue of heat shock protein (HSP) 70 and anti-HSP70 antibodies in chronic rhinosinusitis (CRS) has never been explored. Objective: To determine the nasal secretion (NS) levels of HSP70 and anti-HSP70 antibodies in patients with CRS with nasal polyps (CRSwNP) and patients with CRS without nasal polyps (CRSsNP), and to evaluate their associations with CRS clinical severity and correlation with NS interleukin (IL), IL-5 ...περισσότερα »

Trigger of bronchial hyperresponsiveness development

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

may not always need eosinophilic airway inflammation in very early stage of asthma: This article is currently available as a free download on Ingenta Connect Abstract:Background: Cough variant asthma (CVA), a suggested precursor of standard bronchial asthma (SBA), is characterized by positive bronchial hyperresponsiveness (BHR) and a chronic cough response to bronchodilator that persists for >8 weeks. Objective: Airway inflammation, BHR, and airway obstructive damage were analyzed to assess whether CVA represents early or mild-stage SBA. Methods: Patients with newly dia... περισσότερα »

Men with Primary Sjögren's syndrome (pSS) & Klinefelter's syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome via Clinical Immunology Publication date: Available online 22 April 2016 *Source:*Clinical Immunology Author(s): Valerie M. Harris, Rohan Sharma, Joshua Cavett, Biji T. Kurien, Ke Liu, Kristi A. Koelsch, Astrid Rasmussen, Lida Radfar, David Lewis, Donald U. Stone, C. Erick Kaufman, Shibo Li, Barbara Segal, Daniel J. Wallace, Michael H. Weisman, Swamy Venuturupalli, Jennifer A. Kelly, Marta E. Alarcon-Riquelme, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Debo... περισσότερα »

Wiskott-Aldrich–associated autoinflammation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

[HTML] από sciencedirect.com [HTML] A novel genomic inversion in *Wiskott*-*Aldrich*–*associated autoinflammation* I Brigida, S Scaramuzza, D Lazarevic, D Cittaro… - Journal of Allergy and …, 2016 - Elsevier *Wiskott*-*Aldrich *syndrome (WAS) is an X-linked disorder characterized by thrombocytopenia, eczema, and immunodeficiency. Up to 70% of patients with WAS present with at least 1 autoimmune or *autoinflammatory *episode, and many of them suffer from recurrent or *...* Παράθεση Αποθήκευση Primary immunodeficiency in the neonate: Early diagnosis and management K Walkovich, JA Connel... περισσότερα »

MACVIA Clinical Decision Algorithm in Allergic Rhinitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

in adolescents and adults via Allergy and Clinical Immunology Publication date: Available online 23 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jean Bousquet, Holger J. Schu¨nemann, Peter W. Hellings, Sylvie Arnavielhe, Claus Bachert, Anna Bedbrook, Karl-Christian Bergmann, Sinthia Bosnic-Anticevich, Jan Brozek, Moises Calderon, G. Walter Canonica, Thomas B. Casale, Niels H. Chavannes, Linda Cox, Henry Chrystyn, Alvaro A. Cruz, Ronald Dahl, Giuseppe De Carlo, Pascal Demoly, Philippe Devillier, Gérard Dray, Monica Fletcher, Wytske J. Fokkens, Joao Fonseca... περισσότερα »

Venom immunotherapy : PGE2 and LXA4 in PBMCs are associated with immune tolerance

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

during venom immunotherapy via Allergy and Clinical Immunology Publication date: Available online 22 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Zuzanna Lech, Maciej Chalubinski, Slawomir Kosiński, Ewa Smorawska, Claudio Bassin, Cezmi A. Akdis, Janina Grzegorczyk, Marek L. Kowalski The role of regulatory T cells and related cytokines in the development of the immune tolerance to the antigen following specific immunotherapy of venom allergic patients have been well documented. However, the role of eicosanoid mediators in this process has not been described... περισσότερα »

Exhaled nitric oxide levels and blood eosinophil counts

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity via Allergy and Clinical Immunology Publication date: Available online 22 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Andrei Malinovschi, Christer Janson, Magnus Borres, Kjell Alving BackgroundWe have previously described that fraction of exhaled nitric oxide (Feno) levels and blood eosinophil counts offer additive information in relation to asthma and asthma exacerbations when analyzing data from a large population study.Objecti... περισσότερα »

A new major allergen Cha o 3 from Chamaecyparis obtusa (Japanese cypress) pollen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Identification and gene cloning of via Allergy and Clinical Immunology Publication date: Available online 23 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Toshihiro Osada, Takafumi Harada, Naomasa Asaka, Tomonori Haruma, Kohsuke Kino, Eiji Sasaki, Mitsuhiro Okano, Akira Yamada, Teruhiro Utsugi TeaserWe discovered a novel major allergen, Cha o 3, from Japanese cypress pollen, a known cause of common pollinosis. Our findings may lead to development of new allergen immunotherapies and enhance understanding of Cupressaceae pollinosis.

Serum specific IgE and IgG4 to Dermatophagoides pteronyssinus allergen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Longitudinal profiles of serum specific IgE and IgG4 to Dermatophagoides pteronyssinus allergen and its major components during allergen immunotherapy in a cohort of southern Chinese children via ScienceDirect Publication: Molecular Immunology Publication date: June 2016 *Source:*Molecular Immunology, Volume 74 Author(s): Guangqiao Zeng, Peiyan Zheng, Wenting Luo, Huimin Huang, Nili Wei, Baoqing Sun Longitudinal data on serum specific sIgE and sIgG4 to allergen component of Dermatophagoides pteronyssinus (Der p) during allergen immunotherapy (AIT) are limited in Chinese populations. We... περισσότερα »

Diesel exhaust and allergen modulate miRNA and RNA

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

in intact human epithelium via Allergy and Clinical Immunology Publication date: Available online 24 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Christopher F. Rider, Masatsugu Yamamoto, Oliver P. Günther, Jeremy A. Hirota, Amrit Singh, Scott J. Tebbutt, Chris Carlsten BackgroundAir pollution’s association with asthma may be due its augmentation of allergenic effects, but the role of miRNA and gene expression in this synergy is unknown.ObjectiveTo determine whether exposure to allergen, diesel exhaust (DE) or co-exposures modulates miRNA, gene expression ... περισσότερα »

Once-daily fluticasone furoate and vilanterol

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

for adolescents and adults with symptomatic asthma via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 23 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Gustavo J. Rodrigo, Vicente Plaza BackgroundFluticasone furoate and vilanterol is a new inhaled corticosteroid (ICS) and long-acting β2-agonist (LABA) combination developed for once-daily administration via a dry powder inhaler.ObjectiveTo assess the efficacy and safety of fluticasone furoate–vilanterol in adolescents and adults with symptomatic asthma compare... περισσότερα »

Asthmatic Granulomatosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

*Asthmatic granulomatosis*: A new presentation or a new *asthma *phenotype? *RMD Campos, I Bobolea, MEB Montalvo… - Annals of Allergy, Asthma …, 2016 - Elsevier* *In the last decade, significant efforts have been made to identify the characteristics of severeasthma, which are different from those described in mild to moderate asthma. Currently,severe asthma is recognized as a heterogeneous disease, 1 and asthma management is ...* *Παράθεση Αποθήκευση* Airway-centered fibroelastosis: a distinct entity *P Pradere, C Gauvain, C Danel, MP Debray, R Borie… - Chest, 2016 - Elsevier* *..... περισσότερα »

Outpatient allergy consultations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Synchronous telehealth for via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 19 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Kirk H. Waibel BackgroundTelehealth continues to advance as a health care modality; however, reported experience for synchronous TeleAllergy is limited.ObjectiveTo determine the percentage of new and follow-up visits conducted via TeleAllergy in a hospital-based clinic.MethodsA retrospective study evaluating the first 2 years of a synchronous patient-to-allergist TeleAllergy platform... περισσότερα »

Food allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

needs assessment, training curriculum, and knowledge assessment for child care via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 22 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Bruce J. Lanser, Ronina Covar, J. Andrew Bird BackgroundMore than half of preschool-aged children are enrolled in child care in the United States. Roughly 8% of children between 3 and 5 years of age have a food allergy. Child care center workers (CCCWs) are important caregivers who frequently encounter food allergies, but little is k...περισσότερα »

Treatment with geraniol on ovalbumin-induced allergic asthma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Effect of treatment with geraniol on ovalbumin-induced allergic asthma in mice via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 22 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Zheng Xue, Xin-guang Zhang, Jie Wu, Wan-chao Xu, Li-qing Li, Fei Liu, Jian-er Yu BackgroundAsthma, a complex highly prevalent airway disease, is a major public health problem for which current treatment options are inadequate.ObjectiveTo evaluate the antiasthma activity of geraniol and investigate its underlying molecular mechanisms.... περισσότερα »

Extrapulmonary dissemination of Cryptococcus neoformans (C. neoformans) is one of the most critical steps in the development of meningoencephalitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice: Extrapulmonary dissemination of *Cryptococcus neoformans* (*C. neoformans*) is one of the most critical steps in the development of meningoencephalitis. Here, we report that clearance of the disseminating *C. neoformans* occurs within the brain microvasculature. Interestingly, the efficiency of the intravascular clearance in the brain is reduced compared to that in the lung. Intravascular clearance is mainly mediated by neutrophils, and compleme...περισσότερα »

Molecular diagnosis in pet allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Clinical relevance of Abstract We describe the pattern of sensitisation to pet IgE components and its association with clinical symptoms. 159 consecutive patients with rhinitis/asthma sensitised to dog, cat, and horse were recruited. Specific IgE to whole extracts and to pet recombinant allergens were performed. Only 5% of patients were monosensitised to animal allergens. Specific IgE to Can f 1 was significantly associated with persistent rhinitis, Can f 2 with asthma diagnosis, Can f 3 with moderate/severe rhinitis (M/S-R) and asthma diagnosis (AD), and Can f 5 with persistent and... περισσότερα »

Bortezomib treatment diminishes hazelnut-induced intestinal anaphylaxis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

in mice: Food allergy is a common health problem and can cause anaphylaxis. Avoidance of the offending food allergen is still the mainstay therapeutic approach. In this study, we investigated the role of plasma cell reduction by proteasome inhibition in a murine model of food allergy and examined the impact of this treatment on the systemic and local immune response. For this purpose, intestinal anaphylaxis was induced in BALB/c mice with the food allergen hazelnut, in conjunction with different adjuvants (alum and Staphylococcal enterotoxin B SEB) and different administration rou...περισσότερα »

LPS stimulates IgM production in vivo without help from non-B cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

LPS stimulates IgM production in vivo without help from non-B cells: Gram-negative bacterial LPS induce murine B-cell activation and innate (polyclonal) Ab production. Mouse B cells express the LPS signaling receptor (TLR4), yet how LPS activates B-cell responses *in vivo* is not known. Can LPS directly stimulate B cells to induce innate Ab production? Is activation of non-B cells also required? To address these questions, we transfused LPS-responsive (*Tlr4+/+*) or non-responsive (*Tlr4–/–*) B cells into LPS-responsive or non-responsive mice. Increased expression of the early acti...περισσότερα »

Therapie der akuten Mediastinitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Therapie der akuten Mediastinitis: ZusammenfassungDie akute Mediastinitis ist trotz moderner Therapieverfahren auch heute noch mit einer hohen Morbidität und Mortalität assoziiert. Die wesentlichen Therapiebausteine innerhalb des multidisziplinären Therapiekonzeptes sind die effektive antibiotische Therapie, die intensivmedizinische Behandlung und die Entlastung der beteiligten mediastinalen Kompartimente. Eine frühzeitige Diagnose und kompromisslose Ausschaltung des Infektfokus als Kausaltherapie sind entscheidend für die Verbesserung der Behandlungsergebnisse. Auf der Basis einer...περισσότερα »

HER2-mediated tumorigenesis requires mTORC2

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα

HER2 overexpression drives Akt signaling and cell survival and HER2-enriched breast tumors have a poor outcome when Akt is upregulated. Akt is activated by phosphorylation at T308 via PI3K and S473 via mTORC2. The importance of PI3K activated Akt signaling is well documented in HER2-amplified breast cancer models, but the significance of mTORC2 activated Akt […]

Role of AKT isoforms in estradiol response

The phosphatidylinositol 3-kinase (PI3K) pathway is activated in ~70% of breast cancers. PIK3CA gene mutations or amplifications that affect the PI3K p110α subunit account for activation of this pathway in 20-40% of cases, particularly in estrogen-receptor alpha (ERα)-positive breast cancers. AKT family of kinases, AKT1-3, are the downstream targets of PI3K and these kinases activate […]

JACC: Basic To Translational Science

JACC: Basic To Translational Science, published by American College of Cardiology, last updated on 2016-04-25, available at http://ift.tt/1VyZurh from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VyZurh via IFTTT

Clinical validation of hrHPV testing on vaginal and urine self-samples in primary cervical screening (cross-sectional results from the Papillomavirus Dumfries and Galloway–PaVDaG study)

Objectives Papillomavirus Dumfries and Galloway (PaVDaG) assessed the performance of a high-risk human papillomavirus (hrHPV) PCR-based assay to detect high-grade cervical intraepithelial neoplasia (CIN2+) in self-collected vaginal and urine samples. Setting Women attending routine cervical screening in primary care. Participants 5318 women aged 20–60 years provided self-collected random urine and vaginal samples for hrHPV testing […]

Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study)

Introduction An increasing number of people are living with multimorbidity. The evidence base for how best to manage these patients is weak. Current clinical guidelines generally focus on single conditions, which may not reflect the needs of patients with multimorbidity. The aim of the 3D study is to develop, implement and evaluate an intervention to […]

Qualitative study exploring surgical team members’ perception of patient safety in conflict-ridden Eastern Democratic Republic of Congo

Objective To identify potential barriers to patient safety (PS) interventions from the perspective of surgical team members working in an operating theatre in Eastern Democratic Republic of Congo (DRC). Design In-depth interviews were conducted and analysed using qualitative content analysis. Setting Governmental referral teaching hospital in Eastern DRC. Participants We purposively selected 2–4 national and […]

Building better research partnerships by understanding how Aboriginal health communities perceive and use data: a semistructured interview study

Objective To describe the attitudes and beliefs of health professionals working in Aboriginal Community Controlled Health Services (ACCHS) towards the access, usage and potential value of routinely obtained clinical and research data. Design, setting and participants Face-to-face, semistructured interviews were conducted with 35 health professionals from 2 urban and 1 regional ACCHS in New South […]

Is poor self-rated health associated with low-grade inflammation in 43 110 late adolescent men of the general population? A cross-sectional study

Objective Self-rated health is a powerful predictor of long-term health and mortality, hence the importance of a better understanding of its biological determinants. Previous studies have shown that low-grade inflammation is associated with poor self-rated health in clinical and healthy populations, buthe evidence is sparse in men and completely lacking for men in late […]

What are the barriers to implementation of cardiopulmonary resuscitation training in secondary schools? A qualitative study

Objective Cardiopulmonary resuscitation (CPR) training in schools is recommended to increase bystander CPR and thereby survival of out-of-hospital cardiac arrest, but despite mandating legislation, low rates of implementation have been observed in several countries, including Denmark. The purpose of the study was to explore barriers to implementation of CPR training in Danish secondary schools. Design […]

Has there been a change in the rates of UK sickness certification for back pain over time? An examination of historical data from 2000 to 2010

Objectives This paper aims to investigate historical patterns of sickness certification for back pain from 2000 to 2010. Design Electronic medical records from 14 practices that are part of the National Institute for Health Research (NIHR) Clinical Research Network: West Midlands were reviewed. All records for back pain consultations from 2000 to 2010 were downloaded […]

Immediate Extubation Following Free Tissue Transfer for Head and Neck Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Benefits of J reconstr Microsurg DOI: 10.1055/s-0036-1582262 Background Immediate postprocedure extubation (cessation of mechanical ventilation) after free tissue transfer for head and neck reconstruction may improve outcomes, reduce intensive care unit and hospital length of stay, and reduce overall cost compared with delayed extubation in the intensive care unit. Methods Medical records of 180 consecutive patients undergoing free tissue transfer for head and neck reconstruction were reviewed. Patients immediately extubated in the operating room (immediate group, N = 63) were co...περισσότερα »

Nivea launches NOSE app to detect body odour

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα

Acinetobacter baumannii -- The New MRSA?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα

*Acinetobacter baumannii -- The New MRSA?: Infections caused by this bacteria are commonly multi-drug resistant and can be difficult to treat. Find out what there is to know. * *ePlasty, Open Access Journal of Plastic Surgery * *Virulence. 2012 May 1; 3(3): 243–250.doi: 10.4161/viru.19700PMCID: PMC3442836* Acinetobacter baumannii *An emerging opportunistic pathogen* *Aoife Howard, † Michael O’Donoghue, † Audrey Feeney, and Roy D. Sleator** Department of Biological Sciences; Cork Institute of Technology; Bishopstown, Cork, Ireland *†These authors contributed equally to this work.* ... περισσότερα »

Fistula Rate after primary palatal repair with intravelarveloplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

: a retrospective three-year audit of six units (NorCleft) in the UK via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 23 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Kanwalraj K. Moar, Christopher Sweet, Victoria Beale Our aim was to evaluate the rate of fistulation after one-stage palatal repair by intravelarveloplasty in the NorCleft Cleft Services (Scotland and Northern England), this being a primary outcome measure after repair of a cleft palate. We designed a retrospective, three-year clinical audit of six ... περισσότερα »

Ultrasound-guided and conventional arthrocentesis of the temporomandibular joint

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Comparison of via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 23 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Mustan Barıs Sivri, Yasar Ozkan, Filiz Namdar Pekiner, Gokhan Gocmen Arthrocentesis of the temporomandibular joint (TMJ) can be done either conventionally or under ultrasonographic guidance, and we have compared the effectiveness of the two techniques. Twenty patients who required arthrocentesis of the TMJ were randomly assigned to ultrasonographically guided (US-guided) and conservative arthrocentesi... περισσότερα »

Marking sutures to orientate specimens of basal cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

: do they really make a difference?: Traditionally, marking sutures have been used to orientate specimens of non-melanomatous skin cancers, and they provide an identifiable point as a reference for monitoring and further treatment. For histopathological purposes, the orientated specimen is marked with different inks, which enables measurement to the nearest lateral and deep margins, and if invaded, guides further excision. We retrospectively analysed 688 specimens of basal cell carcinoma (BCC) from the head and neck from two separate years: 2010 and 2012.

Concussion: Osteopathic Manipulative Medicine (OMM)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion: *Conditions*: Post-Concussion Symptoms; Distorted; Balance *Interventions*: Procedure: Osteopathic Manipulative Treatment; Other: Counseling *Sponsor*: New York Institute of Technology ArmsAssigned Interventions Experimental: Osteopathic Manipulative Treatment A board certified NMM/OMM or FP/OMM physician will perform an osteopathic structural exam and osteopathic treatment for a 30 minute session. The investigators will follow a generalized protocol for diag... περισσότερα »

Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus of the rat

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα

Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Paula Santos, Lilian E.C.M. da Silva, Ricardo M. Leão IntroductionSalicylate at high doses induces tinnitus in humans and experimental animals. However, the mechanisms and loci of action of salicylate in inducing tinnitus are still not well known. The expression of Immediate Early Genes (IEG) is traditionally associated with long-term neuronal modifications but it is still not clear how and where IEGs are activated in animal models of tinnitus.ObjectivesHere we investigated t... περισσότερα »

Assessment of Eustachian tube function in patients with tympanic membrane retraction and in normal subjects

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα

Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Inesângela Canali, Letícia P. Schmidt Rosito, Bruno Siliprandi, Cláudia Giugno, Sady Selaimen da Costa IntroductionThe diagnosis of Eustachian tube dysfunctions is essential for better understanding of the pathogenesis of chronic otitis media. A series of tests to assess tube function are described in the literature; however, they are methodologically heterogeneous, with differences ranging from application protocols to standardization of tests and their results.ObjectiveTo ... περισσότερα »

Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

in Esophageal Cancer Patients: *Condition*: Esophageal Cancer *Intervention*: Drug: Itraconazole *Sponsor*: Dallas VA Medical Center ArmsAssigned Interventions Experimental: Itraconazole Itraconazole 300 mg po bid for 14-17 days Drug: Itraconazole

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

– A Prospective Clinical Trial: Follow-Up: by Remo A. G. J. Arts, Erwin L. J. George, Miranda Janssen, Andreas Griessner, Clemens Zierhofer, Robert J. Stokroos Introduction Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) electrical stimulation (without environmental sound perception) with the standard stimulation pattern of a CI (wit... περισσότερα »

5-FU in addition to cisplatin for chemoradiation of locally advanced head-and-neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Do we need ? by Dirk Rades, Daniel Seidl, Stefan Janssen, Amira Bajrovic, Samer G. Hakim, Barbara Wollenberg, Steven E. Schild via Oral Oncology The survival of patients with squamous cell carcinoma of the head-and-neck (SCCHN) has improved during the last 15years [1]. However, many of these patients present with locally advanced or even metastatic disease. The outcome of therapy particular of these patients groups can be further improved. Randomized trials demonstrated that definitive chemoradiation resulted in significantly better treatment outcomes than radiotherapy alone for loca... περισσότερα »

HNC : Image guided surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

in the management of head and neck cancer by Hassan Iqbal, Quintin Pan via Oral Oncology The worldwide incidence of head and neck neoplasm is 900,000 new cases with more than 55,000 newly diagnosed cases reported in the United States each year [1–3]. Surgery, pharmacotherapy, and radiotherapy are regarded as the standard of care for the management of head and neck squamous cell carcinoma. The aim of surgical resection of the tumor is to completely remove the tumor, preserve the normal tissue, and consequently achieve a clear tumor-free resection margin. Surgeons have to rely on visua...περισσότερα »

Using low level laser therapy to reduce early postoperative airway obstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

Using low level laser therapy to reduce early postoperative airway obstruction following modified Hogan's flap via Acta Otorrinolaringológica Española *Source:*Acta Otorrinolaringológica Española Author(s): Abdelrahman E. Ezzat, Hanna M. EL-Shenawy, Marwa M. El-Begermy, Mustafa I. Eid, Ayman Y. Abbas Introduction and objectiveThe most common postoperative complications of velopharyngeal insufficiency surgery are postoperative bleeding and airway obstruction or obstructive sleep apnoea. Consequently, the aim of this study was to evaluate the effect of low level laser therapy (LLLT) duri... περισσότερα »

Nasal closure for the treatment of epistaxis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

secondary to hereditary hemorrhagic telangiectasia via Acta Otorrinolaringológica Española Publication date: Available online 11 April 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Sara Sena Esteves, Carla Cardoso, Ana Silva, José Abrunhosa, Cecília Almeida e Sousa Hereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler-Weber-Rendu syndrome, is an autosomal dominant disorder characterised by the presence of multiple arteriovenous malformations (AVMs) affecting multiple organs. Many procedures have been used for epistaxis control in patients with this... περισσότερα »

Assessment of Eustachian tube function

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

in patients with tympanic membrane retraction and in normal subjects via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Inesângela Canali, Letícia P. Schmidt Rosito, Bruno Siliprandi, Cláudia Giugno, Sady Selaimen da Costa IntroductionThe diagnosis of Eustachian tube dysfunctions is essential for better understanding of the pathogenesis of chronic otitis media. A series of tests to assess tube function are described in the literature; however, they are meth...περισσότερα »

Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

of the rat via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Paula Santos, Lilian E.C.M. da Silva, Ricardo M. Leão IntroductionSalicylate at high doses induces tinnitus in humans and experimental animals. However, the mechanisms and loci of action of salicylate in inducing tinnitus are still not well known. The expression of Immediate Early Genes (IEG) is traditionally associated with long-term neuronal modifications but it is still not clear how and where... περισσότερα »

Foreign body ingestion as a cause of a common carotid artery pseudoaneurysm

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

Foreign body ingestion as a cause of a common carotid artery pseudoaneurysm via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology [image: Contrasted CT scans revealing the presence of a foreign body (arrow) and gas ...] [image: Surgical procedure. (A) In detail, the fish bone (black circle) which perforated ...] Author(s): Maria da Graça Vidal, Juarez Rode, Roger B. da Silva, Anderson Kahlbeck, Erica B. Fontes

Obstructive sleep apnea in postmenopausal women

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

: a comparative study using drug induced sleep endoscopy via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 25 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Soo Kweon Koo, Gun Young Ahn, Jang Won Choi, Young Jun Kim, Sung Hoon Jung, Ji Seung Moon, Young Il Lee IntroductionThe key to successful treatment of OSAS is to individually tailor such treatment. Thus, it is very important to determine the severity of OSAS, its pattern, and the extent of collapse, by gender, age, and BMI.ObjectiveThe objective of the... περισσότερα »

Distribution of proteins within different compartments of tendon varies according to tendon type

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

Abstract Although the predominant function of all tendons is to transfer force from muscle to bone and position the limbs, some tendons additionally function as energy stores, reducing the energetic cost of locomotion. To maximise energy storage and return, energy-storing tendons need to be more extensible and elastic than tendons with a purely positional function. These properties are conferred in part by a specialisation of a specific compartment of the tendon, the interfascicular matrix, which enables sliding and recoil between adjacent fascicles. However, the composition of th...περισσότερα »

Studying avian encephalization with geometric morphometrics

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

Abstract Encephalization is a core concept in comparative neurobiology, aiming to quantify the neurological capacity of organisms. For measuring encephalization, many studies have employed relative brain sizes corrected for expected allometric scaling to body size. Here we highlight the utility of a multivariate geometric morphometric (GM) approach for visualizing and analyzing neuroanatomical shape variation associated with encephalization. GM readily allows the statistical evaluation of covariates, such as size, and many software tools exist for visualizing their effects on shape... περισσότερα »

Heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

The new AbstractThis study aimed to evaluate the effects of low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve with two surgical techniques: end-to-end epineural suture and coaptation with heterologous fibrin sealant. Forty-two male Wistar rats were randomly divided into five groups: control group (CG) in which the buccal branch of the facial nerve was collected without injury; (2) experimental group with suture (EGS) and experimental group with fibrin (EGF): The buccal branch of the facial nerve was transected on both sides of the face. End-to-en... περισσότερα »

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness – A Prospective Clinical Trial: Follow-Up

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness – A Prospective Clinical Trial: Follow-Up: by Remo A. G. J. Arts, Erwin L. J. George, Miranda Janssen, Andreas Griessner, Clemens Zierhofer, Robert J. Stokroos Introduction Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) electrical stimulation (witho...περισσότερα »

The Production of Complement Clauses in Children With Language Impairment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

The Production of Complement Clauses in Children With Language Impairment: Purpose The purpose of this research was to provide a comprehensive description of complement-clause production in children with language impairment. Complement clauses were examined with respect to types of complement structure produced, verb use, and both semantic and syntactic accuracy. Method A group of 17 children with language impairment (mean age = 6;10 [years; months]) was compared with a group of 17 younger children with typical language development (mean age = 4;6). Examples of both nonfinite comp...περισσότερα »

Pediatric Audiology Report: Assessment and Revision of an Audiology Report Written to Parents of Children With Hearing Impairment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Pediatric Audiology Report: Assessment and Revision of an Audiology Report Written to Parents of Children With Hearing Impairment: Objective The purpose of this study was twofold: first, to evaluate a typical pediatric diagnostic audiology report to establish its readability and comprehensibility for parents and, second, to revise the report to improve its readability, as well as the comprehension, sense of self-efficacy, and positive opinions of parent readers. Method In Experiment 1, a mock audiology report was evaluated via a readability analysis and semistructured interviews w... περισσότερα »

Using Language Sample Analysis to Assess Spoken Language Production in Adolescents

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Using Language Sample Analysis to Assess Spoken Language Production in Adolescents: Purpose This tutorial discusses the importance of language sample analysis and how Systematic Analysis of Language Transcripts (SALT) software can be used to simplify the process and effectively assess the spoken language production of adolescents. Method Over the past 30 years, thousands of language samples have been collected from typical speakers, aged 3–18 years, in conversational and narrative contexts. These samples have been formatted as reference databases included with SALT. Using the SAL...περισσότερα »

Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering: Purpose The study identifies teachers' beliefs about and attitudes toward stuttering and explores to what extent these beliefs and attitudes prompt specific teachers' reactions to the stuttering of a student. Method Participants were teachers in secondary education in Flanders (Belgium), currently teaching an adolescent who stutters. They were the student's class teacher or instructed a course in which communication is important. Ten semistructured interviews were conducted and analyzed thematically. Resu...περισσότερα »

Feasibility of a Recasting and Auditory Bombardment Treatment With Young Cochlear Implant Users

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Feasibility of a Recasting and Auditory Bombardment Treatment With Young Cochlear Implant Users: Purpose There is little to guide clinicians in terms of evidence-based interventions for children with cochlear implants who demonstrate morpheme errors. This feasibility study tested the utility of a treatment targeting grammatical morpheme errors. Method Three children (ages 4–5 years) received Enhanced Conversational Recast treatment, a version of conversational recast treatment that focuses on a single morpheme error at a time, emphasizes attention to clinician input, and uses hig... περισσότερα »

Language, Speech, and Hearing Services in Schools

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering Purpose The study identifies teachers' beliefs about and attitudes toward stuttering and explores to what extent these beliefs and attitudes prompt specific teachers' reactions to the stuttering of a student. Method Participants were teachers in secondary education in Flanders (Belgium), currently teaching an adolescent who stutters. They were the student's class teacher or instructed a course in which communication is important. Ten semistructured interviews were conducted and analyzed thematically. Results Te...περισσότερα »

Tinnitus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Talk: Tinnitus is a common condition that affects approximately one out of five people at some point in their life. Yet, the irritating symptoms can often make it feel as though you are the only one suffering. It can also be challenging to keep up with all of the latest research and to find others who can share their experiences with the many different treatment strategies that are available for tinnitus. Fortunately, Tinnitus Talk provides one central location that you can visit to find out everything you need about living with constant sounds in your ear. Catch Up On the Latest ... περισσότερα »

Acinetobacter baumannii -- The New MRSA?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα

Infections caused by this bacteria are commonly multi-drug resistant and can be difficult to treat. Find out what there is to know. *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1Wn9Vgv via IFTTT

Headache in Caucasian patients with Moyamoya angiopathy - a systematic cohort study

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Background Headache is common in patients with Moyanoya angiopathy (MMA), but usually underestimated in its management and not well characterized. Methods A validated self-administered headache screening questionnaire and a telephone interview were used in order to investigate headache characteristics, frequency and pain intensity in a large cohort of 55 German patients with MMA. Results Thirty-seven patients (67.3%) had suffered from headache in the past year. Headache intensity was rated 3.2 ± 1.3 on a verbal rating scale from 0 to 10. Seventeen patients (47.9%) reported mig...περισσότερα »

Headache in Caucasian patients with Moyamoya angiopathy - a systematic cohort study

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

LPS stimulates IgM production in vivo without help from non-B cells

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Gram-negative bacterial LPS induce murine B-cell activation and innate (polyclonal) Ab production. Mouse B cells express the LPS signaling receptor (TLR4), yet how LPS activates B-cell responses *in vivo* is not known. Can LPS directly stimulate B cells to induce innate Ab production? Is activation of non-B cells also required? To address these questions, we transfused LPS-responsive (*Tlr4+/+*) or non-responsive (*Tlr4–/–*) B cells into LPS-responsive or non-responsive mice. Increased expression of the early activation markers CD69 and CD86 could be induced on transfused *Tlr4–/–...περισσότερα »

Tinnitus Talk

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Tinnitus is a common condition that affects approximately one out of five people at some point in their life. Yet, the irritating symptoms can often make it feel as though you are the only one suffering. It can also be challenging to keep up with all of the latest research and to find others who can share their experiences with the many different treatment strategies that are available for tinnitus. Fortunately, Tinnitus Talk provides one central location that you can visit to find out everything you need about living with constant sounds in your ear. Catch Up On the Latest Resear... περισσότερα »

Nasal closure for the treatment of epistaxis secondary to hereditary hemorrhagic telangiectasia

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Publication date: Available online 11 April 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Sara Sena Esteves, Carla Cardoso, Ana Silva, José Abrunhosa, Cecília Almeida e Sousa Hereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler-Weber-Rendu syndrome, is an autosomal dominant disorder characterised by the presence of multiple arteriovenous malformations (AVMs) affecting multiple organs. Many procedures have been used for epistaxis control in patients with this disorder.The objective of this study was to report the treatment of severe HHT-related e...περισσότερα »

Using low level laser therapy to reduce early postoperative airway obstruction following modified Hogan's flap

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Publication date: Available online 13 April 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Abdelrahman E. Ezzat, Hanna M. EL-Shenawy, Marwa M. El-Begermy, Mustafa I. Eid, Ayman Y. Abbas Introduction and objectiveThe most common postoperative complications of velopharyngeal insufficiency surgery are postoperative bleeding and airway obstruction or obstructive sleep apnoea. Consequently, the aim of this study was to evaluate the effect of low level laser therapy (LLLT) during the first postoperative days in children undergoing superiorly based pharyngeal flap (SBF) surge...περισσότερα »

A Prekindergarten Curriculum Supplement for Enhancing Mainstream American English Knowledge in Nonmainstream American English Speakers

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose The purpose of this study was to evaluate the efficacy of a curriculum supplement designed to enhance awareness of Mainstream American English (MAE) in African American English- (AAE-) speaking prekindergarten children. Method Children in 2 Head Start classrooms participated in the study. The experimental classroom received the Talking and Learning for Kindergarten program (Edwards, Rosin, Gross, & Chen, 2013), which used contrastive analysis to highlight morphological, phonological, and pragmatic differences between MAE and AAE. The control classroom received the Kindness ... περισσότερα »

An Investigation of Language Environment Analysis Measures for Spanish–English Bilingual Preschoolers From Migrant Low-Socioeconomic-Status Backgrounds

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose The current study was designed to (a) describe average hourly Language Environment Analysis (LENA) data for preschool-age Spanish–English bilinguals (SEBs) and typically developing monolingual peers and (b) compare LENA data with mean length of utterance in words (MLUw) and total number of words (TNW) calculated on a selected sample of consecutive excerpts of audio files (CEAFs). Method Investigators examined average hourly child vocalizations from daylong LENA samples for 42 SEBs and 39 monolingual English-speaking preschoolers. The relationship between average hourly child... περισσότερα »

Exploring the Utility of a School-Age Narrative Microstructure Index: Proportion of Restricted Utterances

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose This research attempted to replicate Hoffman's 2009 finding that the proportion of narrative utterances with semantic or syntactic errors (i.e., ≥ 14% “restricted utterances”) can differentiate school-age children with typical development from those with language impairment with a sensitivity of 83% and specificity of 88%. Method Methods similar to Hoffman (2009) were used to evaluate an existing set of narratives from 16 age-matched pairs of 8- to 9-year-old children, half with known language impairment. Transcripts were segmented into T-units; a code of [RESTRICTED] was as...περισσότερα »

Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose The study identifies teachers' beliefs about and attitudes toward stuttering and explores to what extent these beliefs and attitudes prompt specific teachers' reactions to the stuttering of a student. Method Participants were teachers in secondary education in Flanders (Belgium), currently teaching an adolescent who stutters. They were the student's class teacher or instructed a course in which communication is important. Ten semistructured interviews were conducted and analyzed thematically. Results Teachers believed that (a) when peers do not react to the stuttering, the l... περισσότερα »

Feasibility of a Recasting and Auditory Bombardment Treatment With Young Cochlear Implant Users

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose There is little to guide clinicians in terms of evidence-based interventions for children with cochlear implants who demonstrate morpheme errors. This feasibility study tested the utility of a treatment targeting grammatical morpheme errors. Method Three children (ages 4–5 years) received Enhanced Conversational Recast treatment, a version of conversational recast treatment that focuses on a single morpheme error at a time, emphasizes attention to clinician input, and uses high linguistic variability with clinician input. A period of recasting was followed by 24 auditory pre... περισσότερα »

Affix Meaning Knowledge in First Through Third Grade Students

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose We examined grade-level differences in 1st- through 3rd-grade students' performance on an experimenter-developed affix meaning task (AMT) and determined whether AMT performance explained unique variance in word-level reading and reading comprehension, beyond other known contributors to reading development. Method Forty students at each grade level completed an assessment battery that included measures of phonological awareness, receptive vocabulary, word-level reading, reading comprehension, and affix meaning knowledge. Results On the AMT, 1st-grade students were significant...περισσότερα »

Using Language Sample Analysis to Assess Spoken Language Production in Adolescents

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα

Purpose This tutorial discusses the importance of language sample analysis and how Systematic Analysis of Language Transcripts (SALT) software can be used to simplify the process and effectively assess the spoken language production of adolescents. Method Over the past 30 years, thousands of language samples have been collected from typical speakers, aged 3–18 years, in conversational and narrative contexts. These samples have been formatted as reference databases included with SALT. Using the SALT software, individual samples are compared with age- and grade-matched samples selecte... περισσότερα »

Adenoidectomy: current approaches and review of the literature.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles Adenoidectomy: current approaches and review of the literature. Kulak Burun Bogaz Ihtis Derg. 2016 May-Jun;26(3):181-90 Authors: Türkoğlu Babakurban S, Aydın E Abstract Adenoid is a secondary lymphoid organ located in the nasopharynx. Due to its location, it plays an important role in the host defense of the upper respiratory tract. Immunoglobulin G3 and… Continue reading Adenoidectomy: current approaches and review of the literature.

Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles [Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma]. Kulak Burun Bogaz Ihtis Derg. 2016 May-Jun;26(3):176-80 Authors: Tiken EE, Çolpan Öksüz D, Batur Ş, Uzel EK, Öz B, Öz F, Uzel Ö, Turkan S Abstract Acantholytic squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. Acantholytic… Continue reading Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma.

Ectopic thyroid tissue localized in submandibular region.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles [Ectopic thyroid tissue localized in submandibular region]. Kulak Burun Bogaz Ihtis Derg. 2016 May-Jun;26(3):172-5 Authors: Düzer S, Akyiğit A, Sakallıoğlu Ö, Solmaz ÖA, Polat C Abstract An ectopic thyroid tissue is often localized in the midline between the foramen caecum and mediastinum, while it is rarely laterally localized. Submandibular location of thyroid tissue… Continue reading Ectopic thyroid tissue localized in submandibular region.

A clinically unsuspected nasopharyngeal sarcoidosis.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles A clinically unsuspected nasopharyngeal sarcoidosis. Kulak Burun Bogaz Ihtis Derg. 2016 May-Jun;26(3):169-71 Authors: Tuğrul S, Göktaş SS, Özücer B, Sönmez FC, Özturan O Abstract Sarcoidosis is a multi-system disease which rarely involves the upper respiratory tract, leading to hoarseness, dysphagia, laryngeal paralysis, and upper airway obstruction. The Waldeyer’s ring involvement in sarcoidosis is… Continue reading A clinically unsuspected nasopharyngeal sarcoidosis.

Tinnitus Talk

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Seasonal influenza vaccine (A/New York/39/2012) effectiveness against influenza A virus of health care workers in a long term care facility attached with the hospital, Japan, 2014/15: A cohort study

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες

Publication date: Available online 23 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Masahiro Ishikane, Hajime Kamiya, Kunio Kawabata, Masahiko Higashihara, Motohiro Sugihara, Ayako Tabuchi, Masao Kuwabara, Yuichiro Yahata, Takuya Yamagishi, Takato Odagiri, Yuko Sugiki, Norio Ohmagari, Tamano Matsui, Kazunori Oishi The 2014/15 influenza season started earlier than usual, and intense activity was reflection of […]

Worldwide Lineages of Clinical Pneumococci in a Japanese Teaching Hospital Identified by DiversiLab System

Publication date: Available online 22 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Kiyoshi Kashiwaya, Tomoo Saga, Yoshikazu Ishii, Ryuji Sakata, Morihiro Iwata, Sadako Yoshizawa, Bin Chang, Makoto Ohnishi, Kazuhiro Tateda Pneumococcal Molecular Epidemiology Network (PMEN) clones are representatives of worldwide-spreading pathogens. DiversiLab system, a repetitive PCR system, has been proposed as a less labor-and […]

A pediatric patient with interstitial pneumonia due to enterovirus D68

Publication date: Available online 22 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Masaaki Matsumoto, Hiroyuki Awano, Miki Ogi, Kazumi Tomioka, Ai Unzaki, Masahiro Nishiyama, Daisaku Toyoshima, Mariko Taniguchi-Ikeda, Akihito Ishida, Hiroaki Nagase, Ichiro Morioka, Kazumoto Iijima Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and […]

First Japanese case of infectious endocarditis due to Enterococcus faecalis small-colony variants

Publication date: Available online 16 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Shinji Ogihara, Ryoichi Saito, Etsuko Sawabe, Michio Hagihara, Shuji Tohda A male patient was admitted to our hospital due to infectious endocarditis. He had been treated with levofloxacin for 6 weeks, sulbactam/cefoperazone for 4 weeks, and benzylpenicillin for 2 days prior to […]

In vitro antimicrobial activity of ozenoxacin against methicillin-susceptible Staphylococcus aureus, methic illin-resistant S. aureus and Streptococcus pyogenes isolated from clinical cutaneous specimens in Japan

Publication date: Available online 16 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Shoji Kanayama, Fumiaki Ikeda, Kazuaki Okamoto, Akiko Nakajima, Tatsumi Matsumoto, Ritsuko Ishii, Ayako Amano, Kaoru Matsuzaki, Satoru Matsumoto Ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against each 50 isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. […]

Case of late-onset bleb associated endophthalmitis caused by Rothia mucilaginosa

Publication date: Available online 11 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Shinya Oie, Kiyofumi Mochizuki, Kyoko Ishida, Asami Nakayama, Kiyofumi Ohkusu Rothia mucilaginosa is a gram-positive coagulase-negative coccus of the family Micrococcaceae. Although R. mucilaginosa forms part of the oropharyngeal microflora, it has only recently been isolated in ocular infections. We report a […]

Empirical therapy in Methicillin-resistant Staphylococcus Aureus infections: An Up-To-Date approach

Publication date: Available online 8 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Alison S. VanEperen, John Segreti Methicillin-resistant Staphylococcus aureus (MRSA) continues to be an important pathogen worldwide, with high prevalence of infection in both community and hospital settings. Timely and appropriate choice of empirical therapy in the setting of MRSA infection is imperative […]

Top 10 Health Benefits of Cayenne Pepper – Pattaya Today

Pattaya Today Top 10 Health Benefits of Cayenne Pepper Pattaya Today Fiercely hot and pungent cayenne pepper is one of the most popular spicy ingredients. Belonging to the capsicum genus, the hotness of cayenne on the Scoville scale is 30,000 to 50,000 Scoville heat units. It is used in whole and powdered form in … […]

Nasal closure for the treatment of epistaxis secondary to hereditary hemorrhagic telangiectasia

Publication date: Available online 11 April 2016 Source:Acta Otorrinolaringológica Española Author(s): Sara Sena Esteves, Carla Cardoso, Ana Silva, José Abrunhosa, Cecília Almeida e Sousa Hereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler-Weber-Rendu syndrome, is an autosomal dominant disorder characterised by the presence of multiple arteriovenous malformations (AVMs) affecting multiple organs. Many procedures have […]

White Dental Fillings Dentist Dallas TX, Smile Makeover Dentistry

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

The post White Dental Fillings Dentist Dallas TX, Smile Makeover Dentistry appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1T0WGMZ via IFTTT

Central mucoepidermoid carcinoma of the mandible: A rare case report with diagnostic dilemma and review of the literature

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Praveer K Banerjee, Abhineet Jain, Sonam Rathi The Egyptian Journal of Otolaryngology 2016 32(2):110-112 Introduction Primary central mucoepidermoid carcinoma of jaws is a rare lesion comprising 2-3% of all mucoepidermoid carcinomas reported in the literature. It affects the mandible as unilocular or multilocular radiographic lesions. Case report The case presented here is that of a […]