TRAINING SPECIFIC FUNCTIONAL, NEURAL AND HYPERTROPHIC ADAPTATIONS TO EXPLOSIVE- VS. SUSTAINED-CONTRACTION STRENGTH TRAINING
Training specificity is considered important for strength training, although the functional and underpinning physiological adaptations to different types of training, including brief explosive contractions, are poorly understood. This study compared the effects of 12-wks of explosive-contraction (ECT, n=13) vs. sustained-contraction (SCT, n=16) strength training vs. control (CON, n=14) on the functional, neural, hypertrophic, and intrinsic contractile characteristics of healthy young men. Training involved 40 isometric repetitions (x3/wk): contracting as fast and hard as possible ... περισσότερα »
The accuracy and robustness of a simple algorithm to measure vessel diameter from B-mode ultrasound images.
Measurement of changes in arterial vessel diameter can be used to assess the state of cardiovascular health, but the use of such measurements as biomarkers is contingent upon the accuracy and robustness of the measurement. This work presents a simple algorithm for measuring diameter from B-mode images derived from vascular ultrasound. The algorithm is based upon Gaussian curve fitting and a Viterbi search process. We assessed the accuracy of the algorithm by measuring the diameter of a digital reference object (DRO) and ultrasound-derived images of a carotid artery. We also assess...περισσότερα »
Triboelectric Nanogenerators: Magnetic-Assisted Noncontact Triboelectric Nanogenerator Converting Mechanical Energy into Electricity and Light Emissions (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] A novel magnetic-assisted noncontact triboelectric nanogenerator (TENG) is proposed by J. H. Hao and co-workers on page 2744. By combining a magnetic-responsive layer, the TENG is remotely operated and controlled with noncontact mechanical motions that can be converted into electricity and light emissions. This work has potential for energy harvesting, magnetic sensors, self-powered electronics, and optoelectronics applications. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1RHP2ec via IFTTT from #Med Blogs ... περισσότερα »
Contents: (Adv. Mater. 14/2016)
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Neurofibromatosis type 1 (NF-1) : a spontaneous neck hematoma
A rare case of a spontaneous neck hematoma in a patient with type 1 neurofibromatosis via Auris Nasus Larynx Publication date: Available online 6 April 2016 *Source:*Auris Nasus Larynx Author(s): Stamatia Dova, Kyriakos Ktenidis, Petros Karkos, Sarantis Blioskas, Georgios Psillas, Alexandros Iliadis, Konstantinos Markou Neurofibromatosis type 1 (NF-1) is a genetic disorder that affects one in 3000 individuals. Although NF-1 notably involves nerves and connective tissue, vascular involvement in large series is estimated to range from 0.4% to 6.4%. Jugular vein involvement in these patie... περισσότερα »
Regarding "Cerebral Angiography for Evaluation of Patients with CT Angiogram-Negative Subarachnoid Hemorrhage: An 11-Year Experience" [LETTERS]
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Reply: [LETTERS]
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Evaluation of Focal Cervical Spinal Cord Lesions in Multiple Sclerosis: Comparison of White Matter-Suppressed T1 Inversion Recovery Sequence versus Conventional STIR and Proton Density-Weighted Turbo Spin-Echo Sequences [SPINE]
BACKGROUND AND PURPOSE: Conventional MR imaging of the cervical spinal cord in MS is challenged by numerous artifacts and interreader variability in lesion counts. This study compares the relatively novel WM-suppressed T1 inversion recovery sequence with STIR and proton density–weighted TSE sequences in the evaluation of cervical cord lesions in patients with MS. MATERIALS AND METHODS: Retrospective blinded analysis of cervical cord MR imaging examinations of 50 patients with MS was performed by 2 neuroradiologists. In each patient, the number of focal lesions and overall lesion... περισσότερα »
Invited Commentary: Using Financial Credits as Instrumental Variables for Estimating the Causal Relationship Between Income and Health
Social epidemiologists are interested in determining the causal relationship between income and health. Natural experiments in which individuals or groups receive income randomly or quasi-randomly from financial credits (e.g., tax credits or cash transfers) are increasingly being analyzed using instrumental variable analysis. For example, in this issue of the *Journal*, Hamad and Rehkopf (*Am J Epidemiol*. 2016;000(00):0000–0000) used an in-work tax credit called the Earned Income Tax Credit as an instrument to estimate the association between income and child development. However...περισσότερα »
Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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Psychotherapie der Suizidalität
Zusammenfassung Psychotherapie ist eine wichtige therapeutische Möglichkeit der Behandlung der Suizidalität. Unabhängig von den verschiedenen Behandlungssettings werden psychotherapeutische Haltungen, Strategien und Techniken vorgestellt, wie sie auf dem Boden verhaltenstherapeutischer und psychoanalytischer Theorien entwickelt wurden. Ausgehend von der gemeinsamen Grundhaltung eines aktiven, zugewandten und für den Patienten auch erkennbaren Therapeuten ist die verhaltenstherapeutische Haltung von dem Gedanken eines „Teams" geprägt, das gegen die Suizidalität antritt. Die zur Sui... περισσότερα »
Beurteilung der Fahrtauglichkeit bei Patienten mit MCI und demenziellen Syndromen
Zusammenfassung Menschen mit leichten kognitiven Störungen („mild cognitive disorders", MCI) und Demenz sind in nahezu allen medizinischen Fachdisziplinen eine häufige und größer werdende Patientengruppe. Die damit verbundenen Herausforderungen berühren neben der unmittelbaren ärztlichen Behandlung nahezu alle Lebensbereiche. Von zunehmender Bedeutung ist die Einschätzung der Fahrtauglichkeit bei Patienten mit kognitiven Defiziten. Welche Möglichkeiten haben Ärztinnen und Ärzte, um zu einer validen Einschätzung zu gelangen? Welche juristischen Aspekte gilt es zu berücksichtigen? We... περισσότερα »
Titanium scaffold osteogenesis in healthy and osteoporotic rats is improved by the use of low-level laser therapy (GaAlAs)
Abstract The present study aimed to assess the effects of low-level laser therapy (GaAlAs) on the bone repair process within titanium scaffolds in the femurs of healthy and osteoporotic rats. Fifty-six rats were divided into four groups: group Sh: SHAM animals that received scaffolds; group LSh: SHAM animals that received scaffolds and were subjected to laser therapy; group OV: ovarietomized (OVX) animals that received scaffolds; and group LOV: OVX animals that received scaffolds and were subjected to laser therapy. Thirty days following ovariectomy or sham surgery, scaffolds were ...περισσότερα »
In vitro investigation on Ho:YAG laser-assisted bone ablation underwater
Abstract Liquid-assisted hard tissue ablation by infrared lasers has extensive clinical application. However, detailed studies are still needed to explore the underlying mechanism. In the present study, the dynamic process of bubble evolution induced by Ho:YAG laser under water without and with bone tissue at different thickness layer were studied, as well as its effects on hard tissue ablation. The results showed that the Ho:YAG laser was capable of ablating hard bone tissue effectively in underwater conditions. The penetration of Ho:YAG laser can be significantly increased up to ... περισσότερα »
Correlation of histological and ex-vivo confocal tumor thickness in malignant melanoma
Abstract The ex-vivo confocal laser scanning microscopy (ex-vivo CLSM) is a novel diagnostic method for fresh tissue examination, which has already shown promising results in the evaluation of healthy skin and different skin tumors. In malignant melanoma, the histological tumor thickness plays an essential role for further treatment strategies. The immediate perioperative measurement of tumor thickness by means of ex-vivo CLSM might accelerate the decision for further operating procedures in malignant melanoma. Ten histologically confirmed malignant melanomas from various donor si... περισσότερα »
In vitro evaluation of photodynamic therapy using curcumin on Leishmania majo r and Leishmania braziliensis
Abstract Cutaneous leishmaniasis is an infectious disease caused by the *Leishmania* protozoan. The conventional treatment is long-lasting and aggressive, in addition to causing harmful effect. Photodynamic therapy has emerged as a promising alternative treatment, which allows local administration with fewer side effects. This study investigated the photodynamic activity of curcumin on *Leishmania major* and *Leishmania braziliensis* promastigote. Both species were submitted to incubation with curcumin in serial dilutions from 500 μg/ml up to 7.8 μg/ml. Control groups were kept in ...περισσότερα »
Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Abstract Background The advantages and utility of microRNAs (miRNAs) as diagnostic and prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to identify and validate the differential expression of miRNAs in oral squamous cell carcinoma (OSCC), to correlate their expression with the clinico-pathological profile of tumours and to identify the signaling pathways through which the aberrantly expressed miRNAs effect tumourigenesis. Methods miRCURY LNA™ array with probes specific to 1168 miRNAs and TaqMan assays specific for 10 miRNAs was employed to...περισσότερα »
An Ultralong, Highly Oriented Nickel-Nanowire-Array Electrode Scaffold for High-Performance Compressible Pseudocapacitors
[image: Thumbnail image of graphical abstract] *Ultralong, highly oriented Ni nanowire arrays* are used as the electrode scaffold to support metal-oxide- and conductive-polymer-based electrode materials with a high mass loading; the as-obtained asymmetric supercapacitor can be compressed by fourfold and exhibits superior energy and power densities with ultrahigh cycle stability. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1NcE4bb via IFTTT
A Highly Efficient Metal-Free Oxygen Reduction Electrocatalyst Assembled from Carbon Nanotubes and Graphene
[image: Thumbnail image of graphical abstract] *A novel carbon nanotube–graphene hybrid nanostructure* is developed using an aerosol-assisted assembly approach. After doping with nitrogen and phosphorus, the prepared hybrid nanomaterials exhibit excellent electrocatalytic performance for oxygen reduction in both alkaline and acidic media. This research presents a continuous and low-cost route to prepare high-performance metal-free electrocatalysts while replacing Pt-based materials. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1qyFRDf via IFTTT
High-Efficiency WOLEDs with High Color-Rendering Index based on a Chromaticity-Adjustable Yellow Thermally Activated Delayed Fluorescence Emitter
[image: Thumbnail image of graphical abstract] *A chromaticity-adjustable yellow thermally activated delayed fluorescence (TADF) material PXZDSO2* as a triplet harvester provides a rational device concept, giving two-color and three-color pure organic white organic light-emitting diodes (WOLEDs) with unprecedented color-rendering index of 95 and external quantum efficiency of 19.2%. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1NcE3UJ via IFTTT
Cancer Therapy: Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With those nanoparticles, a new concept is proposed by Z. Liu and co-workers on page 2716 to enhance radiotherapy by not only using their X-ray absorbing ability to locally concentrate radiation energy in the tumor, but also employing near-infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia-associated radio-resistance. from Biomedical Engineering via xlomafota13 on Inoreader h... περισσότερα »
Masthead: (Adv. Mater. 14/2016)
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Foams: Morphing Metal and Elastomer Bicontinuous Foams for Reversible Stiffness, Shape Memory, and Self-Healing Soft Machines (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] A metal–elastomer-foam composite that can be formed in three dimensions is presented by R. F. Shepherd and co-workers on page 2801. The composite varies dramatically in mechanical properties—from rubbery to stiff—enabling shape change. It also stores shape memory, self-heals, and welds into monolithic structures from smaller components. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/23nuHiv via IFTTT
Memristors: Direct Observation of Localized Radial Oxygen Migration in Functioning Tantalum Oxide Memristors (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] As information bits of 0's and 1's are stored in crosspoint tantalum oxide memristors, or resistive random access memory (RRAM) cells, nanoscale-resolution in operando X-ray transmission spectromicroscopy is used by J. P. Strachan and co-workers, as reported on page 2772, to directly observe oxygen migration and clustering, revealing an important operation and failure mechanism of RRAM, a frontrunner technology for next-generation computer memory. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1RHP4CW via IFTTT
Chemical Sensors: Precisely Controlled Ultrathin Conjugated Polymer Films for Large Area Transparent Transistors and Highly Sensitive Chemical Sensors (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] A precise control over the film thickness is a vital requirement for achievement of high performance in thin-film electronic devices. On page 2752, Y.-Y. Noh and co-workers develop an effective way to deposit a large-area and uniform ultrathin polymer film with a molecular-level precision via a simple wire-wound bar-coating method for high-performance organic transistors and gas sensors. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/23nuImq via IFTTT
Triboelectric Nanogenerators: Magnetic-Assisted Noncontact Triboelectric Nanogenerator Converting Mechanical Energy into Electricity and Light Emissions (Adv. Mater. 14/2016)
[image: Thumbnail image of graphical abstract] A novel magnetic-assisted noncontact triboelectric nanogenerator (TENG) is proposed by J. H. Hao and co-workers on page 2744. By combining a magnetic-responsive layer, the TENG is remotely operated and controlled with noncontact mechanical motions that can be converted into electricity and light emissions. This work has potential for energy harvesting, magnetic sensors, self-powered electronics, and optoelectronics applications. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1RHP2ec via IFTTT
Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations
ABSTRACT Genome-wide association studies (GWAS) have led to the discovery of over 200 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes mellitus (T2DM). Additionally, East Asians develop T2DM at a higher rate, younger age, and lower body mass index than their European ancestry counterparts. The reason behind this occurrence remains elusive. With comprehensive searches… Continue reading Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
ABSTRACT Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian randomization investigation remains problematic, as the conventional inverse-variance weighted method only gives consistent estimates if all of the genetic variants in the analysis are valid… Continue reading Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
Polygenic Epidemiology
ABSTRACT Much of the genetic basis of complex traits is present on current genotyping products, but the individual variants that affect the traits have largely not been identified. Several traditional problems in genetic epidemiology have recently been addressed by assuming a polygenic basis for disease and treating it as a single entity. Here I briefly… Continue reading Polygenic Epidemiology
Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?
ABSTRACT Background Risk of cancer is determined by a complex interplay of genetic and environmental factors. Although the study of gene-environment interactions (G×E) has been an active area of research, little is reported about the known findings in the literature. Methods To examine the state of the science in G×E research in cancer, we performed… Continue reading Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?
Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression
ABSTRACT DNA methylation is a key epigenetic mark involved in both normal development and disease progression. Recent advances in high-throughput technologies have enabled genome-wide profiling of DNA methylation. However, DNA methylation profiling often employs different designs and platforms with varying resolution, which hinders joint analysis of methylation data from multiple platforms. In this study, we… Continue reading Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression
Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method
ABSTRACT Family-based association studies are commonly used in genetic research because they can be robust to population stratification (PS). Recent advances in high-throughput genotyping technologies have produced a massive amount of genomic data in family-based studies. However, current family-based association tests are mainly focused on evaluating individual variants one at a time. In this article,… Continue reading Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method
Risedronate can promote osteoblast differentiation
Effects of risedronate on osteoblastic cell cultures via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Maurilio Malavasi, Ricardo Louro, Marcelo Barbosa Barros, Lucas Novaes Teixeira, Daiane Cristina Peruzzo, Júlio César Joly, Elizabeth Ferreira Martinez, Marcelo Henrique Napimoga ObjectiveBisphosphonates (BPs) have been widely used in the treatment of bone disorders due to their ability to modulate bone turnover. The biological mechanisms through BFs exert their effects on osteoclasts are well established. However, the role of BFs o... περισσότερα »
A Novel Peptide for Simultaneously Enhanced Treatment of HNC and Mitigation of Oral Mucositis.
A Novel Peptide for Simultaneously Enhanced Treatment of Head and Neck Cancer and Mitigation of Oral Mucositis.: PLoS One. 2016;11(4):e0152995 Authors: Chen P, Mancini M, Sonis ST, Fernandez-Martinez J, Liu J, Cohen EE, Toback FG Abstract We have characterized a novel 21 amino acid-peptide derived from Antrum Mucosal Protein (AMP)-18 that mediates growth promotion of cultured normal epithelial cells and mitigates radiation-induced oral mucositis in animal models, while suppressing in vitro function of cancer cells. The objective of this study was to evaluate these dual potential ...περισσότερα »
Honey on oral mucositis
A Randomized controlled trial.: Gulf J Oncolog. 2016;1(20):30-37 Authors: Jayalekshmi JL, Lakshmi R, Mukerji A Abstract BACKGROUND AND OBJECTIVE: The main stream of management of head and neck cancer is by radiotherapy and surgery. During radiation therapy in head and neck cancers, oral cavity is directly exposed to high dose radiation which leads to several side effects - oral mucositis being the most distressing one. This study was intended to assess the effects of applying honey on oral mucositis during radiation therapy. MATERIAL AND METHODS: The research design used in this ... περισσότερα »
4D Visualization of replication foci in mammalian cells corresponding to individual replicons
Article Whether replication happens at individual replicons or in replication factories is a controversial debate. Here the authors use super-resolution microscopy and analysis of replication fork speed to present evidence in favour of replicons. Nature Communications doi: 10.1038/ncomms11231 Authors: V. O. Chagin, C. S. Casas-Delucchi, M. Reinhart, L. Schermelleh, Y. Markaki, A. Maiser, J. J.… Continue reading 4D Visualization of replication foci in mammalian cells corresponding to individual replicons
3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression
Article DNA replication in higher eukaryotes is a complex process occurring in a complex genome environment. Here the authors present a model of DNA replication that incorporates random loop chromatin folding and domino-like fork progression reproducing the spatial and temporal characteristics of S-phase. Nature Communications doi: 10.1038/ncomms11207 Authors: D. Löb, N. Lengert, V. O. Chagin,… Continue reading 3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
Article Over one hundred loci have been identified to be associated with the familial risk of prostate cancer but the functional effects are poorly understood. Here the authors use single-nucleotide variant and epigentic data to show an underlying genetic architecture marked by histone modification. Nature Communications doi: 10.1038/ncomms10979 Authors: Alexander Gusev, Huwenbo Shi, Gleb Kichaev,… Continue reading Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
Giant spin-torque diode sensitivity in the absence of bias magnetic field
Article Nanomagnetic materials allow for the emission and detection of microwave radiation in technological applications by spin excitation. Here, the authors present sensitive room-temperature microwave detectors based on nanoscale magnetic tunnel junctions, enabled via spin torque and injection locking. Nature Communications doi: 10.1038/ncomms11259 Authors: Bin Fang, Mario Carpentieri, Xiaojie Hao, Hongwen Jiang, Jordan A. Katine,… Continue reading Giant spin-torque diode sensitivity in the absence of bias magnetic field
Chemical ordering suppresses large-scale electronic phase separation in doped manganites
Article In oxide materials, cation doping strongly influences the electronic correlations which promote diverse phenomena such as colossal magnetoresistance and superconductivity. Here, the authors use magnetic microscopy to image the effects of spatially ordered doping on electronic phase separation in oxide superlattices. Nature Communications doi: 10.1038/ncomms11260 Authors: Yinyan Zhu, Kai Du, Jiebin Niu, Lingfang Lin,… Continue reading Chemical ordering suppresses large-scale electronic phase separation in doped manganites
Omnivory in birds is a macroevolutionary sink
Article Diet is known to influence speciation, but much less is known about how this process operates at macroevolutionary scales. Using a global dietary database of birds, Burin et al . show that omnivory is associated with higher extinction and lower speciation rates compared to other guilds. Nature Communications doi: 10.1038/ncomms11250 Authors: Gustavo Burin, W.… Continue reading Omnivory in birds is a macroevolutionary sink
Light-enhanced liquid-phase exfoliation and current photoswitching in graphene–azobenzene composites
Article Photochemical isomerisation can engender large conformational rearrangements, giving rise to switchable physical and electronic properties. Here, the authors use azo-benzene derivatives as addressable surfactants to facilitate the exfoliation of graphene and provide light activated modulation. Nature Communications doi: 10.1038/ncomms11090 Authors: Markus Döbbelin, Artur Ciesielski, Sébastien Haar, Silvio Osella, Matteo Bruna, Andrea Minoia, Luca Grisanti,… Continue reading Light-enhanced liquid-phase exfoliation and current photoswitching in graphene–azobenzene composites
Genetic and environmental influences interact with age and sex in shaping the human methylome
Article Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation. Nature Communications doi: 10.1038/ncomms11115 Authors: Jenny van Dongen, Michel G. Nivard,… Continue reading Genetic and environmental influences interact with age and sex in shaping the human methylome
Image-guided transcranial Doppler sonography for monitoring of vasospasm after subarachnoid hemorrhage
Publication date: June 2016 Source:Clinical Neurology and Neurosurgery, Volume 145 Author(s): A. Neulen, E. Prokesch, M. Stein, J. König, A. Giese ObjectivesTranscranial Doppler ultrasound (TCD) is a standard method for bedside vasospasm monitoring after subarachnoid hemorrhage (SAH). Image guidance has previously been shown to reduce intra- and interobserver variability of this method. The aim of… Continue reading Image-guided transcranial Doppler sonography for monitoring of vasospasm after subarachnoid hemorrhage
Smartphones Offer New Opportunities in Clinical Voice Research
Publication date: Available online 7 April 2016 Source:Journal of Voice Author(s): C. Manfredi, J. Lebacq, G. Cantarella, J. Schoentgen, S. Orlandi, A. Bandini, P.H. DeJonckere Smartphone technology provides new opportunities for recording standardized voice samples of patients and sending the files by e-mail to the voice laboratory. This drastically improves the collection of baseline data,… Continue reading Smartphones Offer New Opportunities in Clinical Voice Research
Apatinib in Patients With Differentiated Thyroid Cancer
Study of Apatinib in Patients With Differentiated Thyroid Cancer: *Condition*: Thyroid Cancer *Intervention*: Drug: Apatinib *Sponsor*: Peking Union Medical College Hospital ArmsAssigned Interventions Experimental: Apatinib Apatinib Mesylate Tablets 500 mg qd p.o. Drug: Apatinib Apatinib Mesylate Tablets 500 mg qd p.o. in differentiated thyroid cancer
Protective role of misoprostol against cisplatin-induced ototoxicity
Protective role of misoprostol against cisplatin-induced ototoxicity: AbstractCis-diammineedichloroplatinum (cisplatin) is a chemotherapeutic agent that is widely used in the treatment of many cancers. Nephrotoxicity, ototoxicity and neurotoxicity are dose-limiting adverse effects for cisplatin. The cellular and molecular mechanisms underlying cisplatin-induced ototoxicity aren’t fully understood. It has been proposed that cisplatin primarily cause damage at the cochlea, outer hair cells in particular, leading to excessive production of free oxygen radicals in the organ of Corti, s... περισσότερα »
Comparison of old (75–79 years) to very old (80+ years) hospitalized otorhinolaryngology patients
Comparison of old (75–79 years) to very old (80+ years) hospitalized otorhinolaryngology patients: Abstract BackgroundThe aim was to determine the patients’ characteristics, comorbidity, and inpatient treatment features of very old otorhinolaryngology patients (80+ years) compared to old patients (75–79 years). MethodsA single-center cohort study in a tertiary and university care center was performed with 144 old and 143 very old patients who were hospitalized in 2012. Predictors for differences between old and very old patients were analyzed univariately and multivariately us... περισσότερα »
Bilateral successive sudden sensorineural hearing loss
The clinical analysis of AbstractThe objective of this study is to investigate the clinical characteristics of successive bilateral sudden sensorineural hearing loss (SSNHL) with an interval of more than 1 year to aid the evaluation and management of successive bilateral SSNHL (BSSNHL). 14 successive BSSNHL patients and 118 unilateral SSNHL patients with severe and profound hearing loss were reviewed retrospectively. Information about successive BSSNHL was collected included demographics, the intervals between the attacks of bilateral ears, the past medical history, inducing factor... περισσότερα »
Pleomorphic adenoma in the nasal cavity
: a clinicopathological study of ten cases in Finland: AbstractThe objective of the study was to investigate the nationwide occurrence of sinonasal pleomorphic adenoma in Finland. A retrospective study was conducted at The Departments of Otorhinolaryngology—Head and Neck Surgery, and Pathology at the five university hospitals in Finland. Data were obtained by searching for sinonasal pleomorphic adenoma cases in the clinical and histopathological registries at these institutions for the past two to four decades. All patients who had had a histologically proven pleomorphic adenoma in... περισσότερα »
Hybrid MR/PET Imaging in Neurology: Present Applications and Prospects for the Future
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Response and tolerability of a single dose of 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer: a multicenter retrospective analysis
*Background:* Radiolabelled prostate specific membrane antigen (PSMA) ligands represent a true theranostics concept for diagnosis and therapy of relapsed and metastatic prostate cancer patients. The aim of this study was to evaluate response and tolerability of a single dose of 177Lutetium-PSMA-617 (Lu-PSMA) in a large cohort of patients with metastatic castration resistant prostate cancer (mCRPC). *Methods:* The data of 82 consecutive patients (median age: 73 years, range: 43-87) with metastatic castration resistant prostate cancer who received a single dose of Lu-PSMA (mean: 5.9...περισσότερα »
The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine
Recently, companion diagnostics with nuclear medicine techniques are expected as more suitable means than biopsy for predicting treatment efficacy. The anti-cancer effect of capecitabine, an orally administered chemotherapeutic agent activated by thymidine phosphorylase (TP), positively correlates with tumor TP expression levels. This study aimed to assess whether TP imaging using a radiolabeled uracil derivative, [123I]5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil ([123I]IIMU), could predict the efficacy of capecitabine treatment. *Methods:* Sensitivity to doxifluridine, a metabo...περισσότερα »
Administered Activities for Pediatric Nuclear Medicine Procedures and the Impact of the 2010 North American Guidelines on General Hospitals in the United States
We sought to describe the practice of pediatric nuclear medicine at general hospitals in the US and to assess the impact of dose awareness campaigns like Image Gently. *METHODS:* A web-based survey was developed that requested information regarding hospital type, whether they practiced pediatric nuclear medicine, and their method for determining the administered activity for children. The survey invitation was emailed to a sample of general hospitals with more than 300 beds excluding dedicated pediatric, veterans, psychiatric and rehabilitation hospitals. Data were collected for 5...περισσότερα »
Anti-3-[18F] FACBC (Fluciclovine) PET-CT of Breast Cancer An Exploratory Study
The purpose of this study is to explore the uptake of the synthetic amino acid analog positron emission tomography (PET) radiotracer anti-3-[18F] FACBC (fluciclovine) in breast lesions with correlation to histologic and immunohistochemical characteristics. *Methods:* Twelve women with breast lesions underwent 45 minute dynamic PET-CT of the thorax after intravenous administration of 366.3 ±14.8 (337.44 - 394.05) MBq of fluciclovine. Uptake in the primary lesions at 4 representative time points (5, 17, 29, 41 min) after injection were correlated with histologic, imaging, and clinica...περισσότερα »
Serial quantitative TSPO-targeted PET reveals peak microglial activation up to two weeks after an epileptogenic brain insult.
Experimental and clinical evidence suggests that neuroinflammation, triggered by epileptogenic insults, contributes to seizure development. We employed TSPO-targeted molecular imaging to obtain further insights into the role of microglial activation during epileptogenesis. *Methods:* As epileptogenic insult, a status epilepticus (SE) was induced in rats by lithium-pilocarpine. Rats were subjected to [11C]PK11195 PET scans before SE, immediately after SE, at 1, 2, 5, 7, 14, and 22 days, and 14-16 weeks post SE. For data evaluation, brain regions were outlined by co-registration wit...περισσότερα »
Modulation of abnormal metabolic brain networks by experimental therapies in a nonhuman primate model of Parkinsons disease: an application to human retinal pigment epithelial (hRPE) cell implantation
Abnormal covariance pattern of regional metabolism associated with Parkinson's disease (PD) is modulated by dopaminergic pharmacotherapy. Using high resolution FDG PET and network analysis we previously derived and validated a parkinsonism-related metabolic pattern (PRP) in non-human primate models of PD. It is currently not known whether this network is modulated by experimental therapeutics. In this study we examined changes in network activity by striatal implantation of human levodopa-producing retinal pigment epithelial (hRPE) cells in parkinsonian macaques and evaluated its ... περισσότερα »
Incidental Large Left Masticator Space Mass
Incidental Large Left Masticator Space Mass: A man had a left jaw mass that was associated with an empty socket of the second mandibular molar, was not well circumscribed, and was notably adherent to some surrounding tissues; pathologic assessment demonstrated a squamous lined cyst with parakeratosis. What is your diagnosis? [image: First page PDF preview]
Infiltrative Right Parotid Mass With Lymphadenopathy
Infiltrative Right Parotid Mass With Lymphadenopathy: A man had a right parotid mass infiltrating the overlying facial skin and a postauricular node; MRI showed infiltration into the cartilaginous tissue of the external auditory canal, ipsilateral cervical adenopathy, and possible perineural involvement of the facial nerve. What is your diagnosis? [image: First page PDF preview]
Higher Health Care Costs in Middle-aged Adults With Hearing Loss
Higher Health Care Costs in Middle-aged US Adults With Hearing Loss: This study uses data from the Truven Health MarketScan database to compare the costs of health care for a matched cohort of privately insured, middle-aged individuals with and without a diagnosis of hearing loss. This study uses data from the Truven Health MarketScan database to compare the costs of health care for a matched cohort of privately insured, middle-aged individuals with and without a diagnosis of hearing loss. Age-related hearing loss affects more than 60% of US adults older than 70 years and has been... περισσότερα »
Complications Following Pediatric Tracheotomy
Complications Following Pediatric Tracheotomy: This 13-year medical record review identifies the type and rate of complications arising from pediatric tracheotomy. *Importance* Pediatric tracheotomy is a complex procedure with significant postoperative complications. Wound-related complications are increasingly reported and can have considerable impact on clinical course and health care costs to tracheotomy-dependent children. *Objective* The primary objective of this study was to identify the type and rate of complications arising from pediatric tracheotomy. *Design, Setting, a...περισσότερα »
Documentation Improvement Program for Academic Otolaryngology Practice
Documentation Improvement Program for Academic Otolaryngology Practice: This pre-post study identifies areas of deficiency in inpatient documentation and instructs health care professionals on how to improve the quality and accuracy of clinical records. *Importance* Physicians recognize the value of accurate documentation to facilitate patient care, communication, and the distribution of professional fees. However, the association between inpatient documentation, hospital billing, and quality metrics is less clear. *Objectives* To identify areas of deficiency in inpatient docume...περισσότερα »
Preventing Recreational Noise–Induced Hearing Loss
Preventing Recreational Noise–Induced Hearing Loss: This randomized clinical trial assesses the effectiveness of earplugs in preventing temporary hearing loss immediately following loud music exposure. and concerts may contribute to this increasing problem. *Objective* To assess the effectiveness of earplugs in preventing temporary hearing loss immediately following music exposure. *Design, Setting, and Participants* A randomized, single-blind clinical trial was conducted on September 5, 2015, at an outdoor music festival in Amsterdam, the Netherlands. Normal-hearing adult volunt... περισσότερα »
Prognostic role of the Bethesda System for conventional papillary thyroid carcinoma
Prognostic role of the Bethesda System for conventional papillary thyroid carcinoma: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background The purpose of this study was to investigate the role of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) as a prognostic marker in conventional papillary thyroid carcinoma (PTC). Methods A total of 397 patients who underwent ultrasound-guided fine-needle aspiration biopsy (FNAB) and surgery for conventional PTCs were enrolled. The association between the Bethesda category and histopathologic result was evaluate... περισσότερα »
Clinical outcomes of patients with hypercalcitoninemia after initial treatment for medullary thyroid cancer and postoperative serum calcitonin cutoffs for predicting structural recurrence
Clinical outcomes of patients with hypercalcitoninemia after initial treatment for medullary thyroid cancer and postoperative serum calcitonin cutoffs for predicting structural recurrence: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Persistent hypercalcitoninemia is reported in 40% to 60% of patients with medullary thyroid cancer (MTC) after initial therapy, but their clinical outcomes have not been clearly studied. We evaluated the outcomes of MTC with hypercalcitoninemia and assessed the cutoffs of postoperative serum calcitonin for predicting structu... περισσότερα »
Factors influencing the incidence and prognosis of second primary tumors in patients with oral squamous cell carcinoma
Factors influencing the incidence and prognosis of second primary tumors in patients with oral squamous cell carcinoma: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Although second primary tumors are common in patients with oral squamous cell carcinoma (OSCC), their predisposing factors and treatment guideline remain uncertain. Methods Three hundred ninety-four patients with OSCC who received radical surgery from January 2002 to December 2009 were retrospectively reviewed. Results Forty-five patients developed oral second primary tumors. Areca quid chewin... περισσότερα »
Antitumor effect of CXCR4 antagonist AMD3100 on the tumorigenic cell line of BHP10-3 papillary thyroid cancer cells
Antitumor effect of CXCR4 antagonist AMD3100 on the tumorigenic cell line of BHP10-3 papillary thyroid cancer cells: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background A tumorigenic cell line (BHP10-3M) derived from nontumorigenic papillary thyroid carcinoma (PTC) cells (BHP10-3) having rearranged during transfection (RET)/*PTC1* gene rearrangement might have a higher expression of CXCR4, either quantitatively or functionally. The authors also postulated that CXCR4-mediated invasion or tumorigenesis could be blocked by CXCR4 antagonists, including AMD3100. Met...περισσότερα »
Myopericytoma arising adjacent to the common carotid artery
Case report and systematic review of deep located neck myopericytomas: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Myopericytoma is a perivascular tumor of the skin and subcutaneous tissue of the extremities, it is a rare finding in the head and neck, and even rarer is its deep location. Methods A 38-year-old woman presented with a slowly growing mass at the right carotid triangle. Contrast-enhanced CT scan revealed a moderately enhancing mass. At surgery, the tumor was firmly attached to the common carotid artery, making it necessary to excise a small p... περισσότερα »
Concurrent cetuximab and postoperative radiation in resected high-risk HNSCC
squamous cell carcinomas of the head and neck: A single-institution experience: Abstract Background Postoperative cisplatin and radiation is the standard of care for high-risk squamous cell carcinoma of the head and neck (SCCHN). We have used cetuximab and radiation in the postoperative setting for patients deemed poor candidates for cisplatin. Methods We retrospectively identified 40 patients who received cetuximab and radiation for resected locoregionally advanced SCCHN between 2006 and 2013 at our institution. Results The 2-year Kaplan–Meier estimates were: overall survival (OS) ...περισσότερα »
Potential risk factors and outcomes of fistulas between the upper intestinal tract and the airway following Ivor-Lewis esophagectomy
Potential risk factors and outcomes of fistulas between the upper intestinal tract and the airway following Ivor-Lewis esophagectomy: Summary Fistulas between the upper intestinal tract and the airway following esophagectomy are a rare and severe complication with significant mortality. Treatment and therapy are difficult and require a multidisciplinary approach. The objective of this retrospective study was to identify risk factors for these fistulas following esophagetcomy, and to assess their impact on the further clinical course and outcome. 211 patients undergoing Ivor-Lewis e... περισσότερα »
Two novel polymorphisms in PLCE1 are associated with the susceptibility to ESCC
in Chinese population: Summary Esophageal cancer is the sixth leading cause of cancer-associated death worldwide. Phospholipase C epsilon 1 (*PLCE1*) gene was found to be associated with the risk of esophageal squamous cell carcinoma (ESCC) by three large-scale genome-wide association studies (GWAS) in Chinese populations. To evaluate the association between the single nucleotide polymorphisms (SNPs) in *PLCE1* gene and ESCC risk, a case–control study including 550 patients with ESCC and 550 age, gender-matched controls was carried out to investigate the genetic susceptibility of ... περισσότερα »
Lipopolysaccharide-induced toll-like receptor 4 signaling in ESCC
promotes tumor proliferation and regulates inflammatory cytokines expression: Summary Emerging evidence suggests toll-like receptor 4 (TLR4) signaling contributes to cancer development and progression. However, the consequences of signaling via the TLR4 pathway in esophageal squamous cell carcinoma (ESCC) are still unclear. Here, we investigated the impact of Lipopolysaccharide (LPS)-induced TLR4 signaling on ESCC cell proliferation, inflammatory cytokines expression, and downstream molecular mechanisms. Seventy-eight ESCC and 26 normal esophageal specimens were analyzed by immun... περισσότερα »
The intrapapillary capillary loop (IPCL) changes in superficial esophageal lesions
The intrapapillary capillary loop (IPCL) changes in superficial esophageal lesions: Summary The aims of this study were to investigate intrapapillary capillary loops (IPCLs) of superficial esophageal lesions changes in different types classified by the Japan Esophageal Society classification. The calibers, areas, and densities of IPCLs were detected in 34 cases of esophageal lesions using immunohistochemical analysis. Statistically significant differences in calibers, areas, and densities of IPCLs were observed between type A, type B1/B2, and type B3 area (*P* < 0.001). In conclusi... περισσότερα »
Waardenburg syndrome type II caused by a novel nonsense mutation in the SOX10 gene
in a Chinese patient via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 7 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Jing Ma, Tie-song Zhang, Ken Lin, Hao Sun, Hong-chao Jiang, Yan-li Yang, Fan Low, Ying-qin Gao, Biao Ruan ObjectiveWaardenburg syndrome is a congenital genetic disorder. It is the most common type of syndromic hearing impairment with highly genetic heterogeneity and proved to be related by 6 genes as follows: PAX3, MITF, SNAI2, EDN3, EDNRB and SOX10. This article aims to identify the g...περισσότερα »
The Epidemiology of Olfactory Disorders
The Epidemiology of Olfactory Disorders: AbstractInsights into risk factors for olfactory decline are needed, because knowledge about its origin is limited. This impairment has important implications for human health. Several epidemiologic studies of olfaction provide insight into the prevalence of olfactory disorders. Here, we review the major population studies carried out on this topic to date. Our purpose is to characterize knowledge about olfactory disorders from human studies. We also describe the existing methods for measuring the sense of smell in population studies, presen... περισσότερα »
Laryngomalacia : Recommendations for the comprehensive management of young infants who present with signs or symptoms
Laryngomalacia consensus recommendations via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 7 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): John Carter, Reza Rahbar, Matthew Brigger, Kenny Chan, Alan Cheng, Sam J. Daniel, Alessandro De Alarcon, Noel Garabedian, Catherine Hart, Christopher Hartnick, Ian Jacobs, Bryan Liming, Richard Nicollas, Seth Pransky, Gresham Richter, John Russell, Michael J. Rutter, Anne Schilder, Richard J.H. Smith, Julie Strychowsky, Robert Ward, Karen Watters, Michelle Wyatt, Geo... περισσότερα »
Endoscopic bilateral congenital choanal atresia repair
of 112 cases, evolving concept and technical experience via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Hesham Mohammad Eladl, Yasser W. Khafagy ObjectiveThis study aims to present 18 years’ experience with endoscopic treatment of bilateral congenital choanal atresia as regard to management concept, surgical technique, results, pitfalls, and complications.Patients and methodsA retrospective study including 112 cases of bilateral congenital choanal atresia, treate... περισσότερα »
Radical ethmoidectomy for nasal polyposis (nasalisation)
Refinement of the nasalisation technique for nasal polyposis via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 7 April 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): M.-A. Jiménez-Chobillon, F.A. Martínez-Castillo, E. Valdés-Hernández, L. Cristerna-Sánchez BackgroundRadical ethmoidectomy for nasal polyposis (nasalisation) tends to offer better results than functional ethmoidectomy in terms of recurrence. We have been performing the nasalisation technique since 2004, but late complications such a... περισσότερα »
Oral cavity, pharynx and larynx nodules
Oral cavity, pharynx and larynx nodules via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 7 April 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): A. Sumarroca, A. Codina, X. León [image: Nodules in the oral cavity predominantly involving the palate and the tongue.] [image: (A) Haematoxylin–eosin stain of the spindle cell tumour with vascular ...]
Volatile sulphur compound (VSC) levels : Evaluation of halitosis using a portable gas chromatograph
Evaluation of halitosis using OralChroma™ in patients with allergic rhinitis via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 7 April 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): M.O. Avincsal, A. Altundag, M.E. Dinc, M. Cayonu, M. Topak, M. Kulekci ObjectiveThe objective of this study was to evaluate the occurrence of halitosis in patients with allergic rhinitis (AR).Materials and methodsIn this study, we enrolled 53 patients with AR and 34 participants as controls. Halitosis was evaluated b...περισσότερα »
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale
*Thyroïde ectopique basi-linguale* *via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale* *Publication date: April 2016Source:Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2Author(s): J. Gotlib, A. Ianessi, J. Santini, O. Dassonville* *[image: IRM en coupe axiale pondérée en séquence T1 objectivant une thyroïde ectopique ...] [image: Vue peropératoire de la thyroïde basi-linguale.]* *Balle fongique et carcinome épidermoïde concomitants du sinus maxillaire* *via ScienceDirect Publi...περισσότερα »
Chirurgie du tractus thyréoglosse
. Technique de Sistrunk via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): C.-A. Righini, A. Hitter, E. Reyt, I. Attalah Les kystes de la partie médiane du cou sont les malformations congénitales les plus fréquentes de la région cervicale. Ils se développent le long du tractus thyréoglosse (TTG). La présence d’une fistule est la conséquence d’une fistulisation soit spontanée (suppurati... περισσότερα »
L’épistaxis secondaire à la rupture d’un anévrisme de la carotide intra-caverneuse
Anévrismes géants bilatéraux de la carotide intra-caverneuse compliqués par des épistaxis via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): P.-L. Sadigh, A. Clifton, A. Toma IntroductionL’épistaxis secondaire à la rupture d’un anévrisme de la carotide intra-caverneuse, qui s’est érodé pour s’ouvrir dans le sinus sphénoïdal, met en jeu le pronostic vital. Si le phénomène est unilatéral... περισσότερα »
Sinusite sphénoïdale et abcès de la fosse infratemporale
par Nocardia nova via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): A. Giordano, M. Cohen-Salmon, B. Joly, C. Maffiolo IntroductionLes sinusites par Nocardia sont exceptionnelles, nous rapportons un cas de sinusite sphénoïdale compliquée d’un abcès de la fosse infratemporale : une recherche dans la base Medline retrouve un seul cas rapporté. Nous rapportons un nouveau cas qui a posé ...περισσότερα »
Le syndrome de Lemierre
Un syndrome de Lemierre atypique via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): M. Risoud, G. Mortuaire, D. Chevalier, B. Rysman IntroductionLe syndrome de Lemierre complique une infection oropharyngée et associe une thrombophlébite septique de la veine jugulaire interne avec septicémie et emboles septiques à distance (surtout pulmonaires). Nous rapportons un cas atypique avec thro... περισσότερα »
L’ostéomyélite du sinus frontal
À propos d’un cas de tumeur de Pott post-traumatique via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): P. Clarós, H. Ahmed, A. Clarós IntroductionL’ostéomyélite du sinus frontal est une présentation clinique rare. Elle se produit généralement en tant que complication d’un traumatisme de la région frontale ou d’une sinusite frontale. Ses complications peuvent être menaçantes pour la vi... περισσότερα »
Prof. Dr.med. Dr.med.h.c.mult. Wolfgang Kühnel (1934–2015)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Publication date: Available online 7 April 2016 *Source:*Annals of Anatomy - Anatomischer Anzeiger Author(s): Adolf-Friedrich Holstein from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1V0YAns via IFTTT
Les troubles de l’odorat
Exploration de l’odorat : l’état de l’art via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): D.T. Nguyen, C. Rumeau, P. Gallet, R. Jankowski Les troubles de l’odorat sont assez fréquents dans la population générale. Cependant, l’exploration de l’odorat est encore peu pratiquée en ORL, même dans les centres hospitaliers de référence. Cette attitude peut être expliquée par trois raisons ...περισσότερα »
Mycobactéries atypiques de localisation cervico-faciale
: à propos de 30 cas via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): P. Rives, M. Joubert, E. Launay, A. Guillouzouic, F. Espitalier, O. Malard IntroductionL’infection à mycobactérie est la cause la plus commune de granulome cervical : elle peut être due à une mycobactérie, tuberculeuse ou non, appelée mycobactérie atypique (MA). Les MA sont des organismes ubiquitaires retrouvés d... περισσότερα »
Notation automatisée des réponses en audiométrie vocale
: validation en langue française du logiciel OTOSPEECH via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): F. Venail, E. Legris, B. Vaerenberg, J.-L. Puel, P.J. Govaerts, J.-C. Ceccato ObjectifsValider une nouvelle méthode d’audiométrie vocale utilisant des listes personnalisées, enregistrées par le sujet à tester, et bénéficiant d’une notation automatique.Patients et méthodesL’effet d... περισσότερα »
Dépistage néonatal de la surdité
: prévalence et prise en charge médicale et paramédicale des surdités bilatérales dans une cohorte de nouveau-nés en Île-de-France via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): M. Antoni, I. Rouillon, F. Denoyelle, E.-N. Garabédian, N. Loundon ButsRésultats du dépistage néonatal de la surdité d’une cohorte d’enfants nés en Île-de-France, dans le cadre du programme national mis en...περισσότερα »
Étude radioanatomique du canal semicirculaire supérieur
Étude radioanatomique du canal semicirculaire supérieur via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): N. Klop-Dutote, C. Kolski, A. Biet, V. Strunski, C. Page ObjectifsIl s’agissait de déterminer l’existence d’une relation entre la prévalence de la déhiscence du canal semicirculaire supérieur (CSCS) sur un scanner des rochers et l’âge de la population. L’objectif secondaire était ...περισσότερα »
La pycnodysostose
Pycnodysostoses révélées par un stridor atypique via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): L. Manfredi, S. Marlin, B. Fauroux, E.N. Garabedian, V. Couloigner, N. Leboulanger ObjectifsLa pycnodysostose est une maladie génétique rare, causée par une mutation du gène de la cathepsine K, impliquée dans le renouvellement osseux. Elle associe notamment un nanisme et une fragilité os... περισσότερα »
La mucormycose en ORL
. À propos de 4 observations via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: April 2016 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 133, Issue 2 Author(s): W. Kermani, R. Bouttay, M. Belcadhi, H. Zaghouani, M. Ben Ali, M. Abdelkéfi ObjectifsLes mucormycoses sont des infections opportunistes survenant habituellement sur un terrain immunodéprimé. Elles sont rares et souvent fatales. Elles sont dues à des champignons filamenteux de type mucorales. Les auteurs di...περισσότερα »
Next Generation Sequencing and the Microbiome of Chronic Rhinosinusitis: A Primer for Clinicians and Review of Current Research, Its Limitations, and Future Directions
Next Generation Sequencing and the Microbiome of Chronic Rhinosinusitis: A Primer for Clinicians and Review of Current Research, Its Limitations, and Future Directions: Objective: Microbiomics in chronic diseases, including chronic rhinosinusitis (CRS), have undergone rapid advances in recent times. The introduction of Next Generation Sequencing (NGS) technology has produced significant clinical insights regarding the bacteriology of these conditions. We review studies that have used 16S rRNA sequencing to specifically investigate the microbiota profiles of patients with CRS in a va...περισσότερα »
Is NBI-Guided Resection a Breakthrough for Achieving Adequate Resection Margins in Oral and Oropharyngeal Squamous Cell Carcinoma?
Is NBI-Guided Resection a Breakthrough for Achieving Adequate Resection Margins in Oral and Oropharyngeal Squamous Cell Carcinoma?: Objectives: Obtaining free resection margins is the main goal of oncological surgeons. Narrow-band imaging (NBI) has been recently used to help define resection margins in transoral laser microsurgery for laryngeal carcinoma. The aim of this study was to evaluate the effect of intraoperative NBI in defining the surgical resection margins of oral and oropharyngeal cancers. Methods: Between January 2014 and March 2015, NBI was used intraoperatively after ...περισσότερα »
Responses to errors and adverse events
The need for a systems approach in otolaryngology: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To report otolaryngologists' reactions to errors and adverse events and determine if temporal changes in physician efforts to assume responsibility; ameliorate patients' conditions; or change personal, group-wide, or hospital practices have occurred. Study Design Mixed-methods analysis of survey entries detailing responses to errors and adverse events. Methods Members of the American Academy of Otolaryngology–Head and Neck Surgery were asked to report errors ... περισσότερα »
The impact of delayed surgical drainage of deep neck abscesses in adult and pediatric populations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objectives/Hypothesis The conventional treatment for deep neck abscesses in adults is antibiotic therapy with surgical drainage, whereas in children there is debate about the role of surgical drainage versus conservative therapy. It is presently unclear if delayed surgical drainage negatively affects outcomes. Study Design We performed a multicenter, prospective, risk-adjusted cohort study of adult and […]
Responses to errors and adverse events: The need for a systems approach in otolaryngology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objectives/Hypothesis To report otolaryngologists’ reactions to errors and adverse events and determine if temporal changes in physician efforts to assume responsibility; ameliorate patients’ conditions; or change personal, group-wide, or hospital practices have occurred. Study Design Mixed-methods analysis of survey entries detailing responses to errors and adverse events. Methods Members of the American Academy of Otolaryngology–Head […]
Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan – TCHS-E
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Abstract This study assesses interactions of tumor necrosis factor α (TNF-α) gene polymorphisms with C-reactive protein (CRP) or lymphotoxin α (LTA) gene on serum CRP and TNF-α levels and handgrip strength. Eleven single nucleotide polymorphisms (SNPs), including rs2794520, rs1205, rs1130864, rs1800947, and rs3093059 in CRP; rs1799964, rs1800629, and rs3093662 in TNF-α; and rs2239704, rs909253, and […]
Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Abstract Background The advantages and utility of microRNAs (miRNAs) as diagnostic and prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to identify and validate the differential expression of miRNAs in oral squamous cell carcinoma (OSCC), to correlate their expression with the clinico-pathological profile of tumours and to identify […]
SKPs plays a role in nerve regenerationStudy of synergistic role of allogenic skin-derived precursor differentiated Schwann cells and heregulin-1β in nerve regeneration with an acellular nerve allograft
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: Available online 7 April 2016 Source:Neurochemistry International Author(s): Houlei Wang, Jingping Wu, Xinchao Zhang, Lei Ding, Qingmin Zeng Development of tissue structure and three-dimensional microenvironment is crucial for regeneration of axons in the peripheral nerve repair. In this study we aimed to evaluate the efficacy of nerve regeneration by using an acellular nerve […]
Ecografía dermatológica de la necrosis grasa encapsulada
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: Available online 7 April 2016 Source:Actas Dermo-Sifiliográficas Author(s): B. Echeverría-García, A. Hernández-Nuñez, J. Borbujo from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Yiekjy via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The need for community pharmacists in oncology outpatient care: a systematic review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Abstract Background One-third of all deaths in Europe each year are attributable to cancer. Issues relating to cancer care, therefore, will continue to expand. To manage the increased challenges—including doctor shortages, an ageing population, and rural distribution of supplies—community pharmacists will likely be required to assume responsibility within oncology care. Aim of the review To […]
Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
ABSTRACT Genome-wide association studies (GWAS) have led to the discovery of over 200 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes mellitus (T2DM). Additionally, East Asians develop T2DM at a higher rate, younger age, and lower body mass index than their European ancestry counterparts. The reason behind this occurrence remains elusive. With comprehensive searches […]
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
ABSTRACT Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian randomization investigation remains problematic, as the conventional inverse-variance weighted method only gives consistent estimates if all of the genetic variants in the analysis are valid […]
Polygenic Epidemiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
ABSTRACT Much of the genetic basis of complex traits is present on current genotyping products, but the individual variants that affect the traits have largely not been identified. Several traditional problems in genetic epidemiology have recently been addressed by assuming a polygenic basis for disease and treating it as a single entity. Here I briefly […]
The impact of delayed surgical drainage of deep neck abscesses in adult and pediatric populations
[image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis The conventional treatment for deep neck abscesses in adults is antibiotic therapy with surgical drainage, whereas in children there is debate about the role of surgical drainage versus conservative therapy. It is presently unclear if delayed surgical drainage negatively affects outcomes. Study Design We performed a multicenter, prospective, risk-adjusted cohort study of adult and pediatric patients with deep neck abscess who received incision and drainage within 7 days of admission in the American College of...περισσότερα »
Responses to errors and adverse events: The need for a systems approach in otolaryngology
[image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To report otolaryngologists' reactions to errors and adverse events and determine if temporal changes in physician efforts to assume responsibility; ameliorate patients' conditions; or change personal, group-wide, or hospital practices have occurred. Study Design Mixed-methods analysis of survey entries detailing responses to errors and adverse events. Methods Members of the American Academy of Otolaryngology–Head and Neck Surgery were asked to report errors or adverse events. Responses to open- and closed... περισσότερα »
Chemical composition, in vitro antioxidant and anti-inflammatory properties of essential oils of four dietary and medicinal plants from Cameroon
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background In the Cameroonian traditional medicine, plants of the Capparidaceae, Euphorbiaceae and Liliaceae families are used to treat several metabolic diseases. These plants are rich in various compounds belonging to the glucosinolates and thiosulfinates family. Till date, very little studies have been done aiming at assessing the antioxidant and inflammatory properties of the essential […]
The impact of delayed surgical drainage of deep neck abscesses in adult and pediatric populations
The impact of delayed surgical drainage of deep neck abscesses in adult and pediatric populations: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis The conventional treatment for deep neck abscesses in adults is antibiotic therapy with surgical drainage, whereas in children there is debate about the role of surgical drainage versus conservative therapy. It is presently unclear if delayed surgical drainage negatively affects outcomes. Study Design We performed a multicenter, prospective, risk-adjusted cohort study of adult and pediatric patients with deep ne... περισσότερα »
Oral squamous cell carcinoma: microRNA expression
profiling and integrative analyses for elucidation of tumourigenesis mechanism via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12943&channel-name=Molecular+Cancer AbstractBackgroundThe advantages and utility of microRNAs (miRNAs) as diagnostic and prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to identify and validate the differential expression of miRNAs in oral squamous cell carcinoma (OSCC), to correlate their expression with the clinico-pathological profile of tumours and to identify the signaling pat... περισσότερα »
Smartphones Offer New Opportunities in Clinical Voice Research
Publication date: Available online 7 April 2016 *Source:*Journal of Voice Author(s): C. Manfredi, J. Lebacq, G. Cantarella, J. Schoentgen, S. Orlandi, A. Bandini, P.H. DeJonckere Smartphone technology provides new opportunities for recording standardized voice samples of patients and sending the files by e-mail to the voice laboratory. This drastically improves the collection of baseline data, as used in research on efficiency of voice treatments. However, the basic requirement is the suitability of smartphones for recording and digitizing pathologic voices (mainly characterized by ... περισσότερα »
Word Intelligibility in Multi-voice Singing: The Influence of Chorus Size
Publication date: Available online 7 April 2016 *Source:*Journal of Voice Author(s): Nathaniel Condit-Schultz, David Huron ObjectiveThis study investigated how the intelligibility of sung words is influenced by the number of singers in a choral music style.MethodsThe study used repeated measures factorial. One hundred forty-nine participants listened to recordings of spoken and sung English words and attempted to identify the words. Each stimuli word was sung or spoken in sync by either one, four, eight, sixteen, or twenty-seven members of a high-quality Soprano Alto Tenor Bass (SAT... περισσότερα »
Impairment of an atrophic mandible by preparation of the implant cavity: a biomechanical study
Publication date: Available online 7 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Timm Steiner, Tobias Torsiglieri, Andrea Rau, Stephan C. Möhlhenrich, Stefan Eichhorn, Isabella Grohmann, Herbert Deppe, Frank Hölzle, Stefan Raith An important complication during insertion of implants in atrophic mandibles is the fracture that can be induced by preparation of the cavity. We designed this study to identify which configuration of cavities in the interforaminal region was the least likely to fracture. An electromechanical testing machine was used to m... περισσότερα »
Mechanical evaluation of six techniques for stable fixation of the sagittal split osteotomy after counterclockwise mandibular advancement
Publication date: Available online 7 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Leandro Benetti De Oliveira, Jose Mauricio Nunes Reis, Rubens Spin-Neto, Marisa Aparecida Cabrini Gabrielli, Yener Oguz, Valfrido Antonio Pereira-Filho We have evaluated the resistance to displacement of six stable methods of fixation of a sagittal split ramus osteotomy (SSRO) in the mandibular advancement with counterclockwise rotation. We tested 60 synthetic hemimandibles in six groups of 10 each: Group I – fixation with a straight four-hole 2.0mm miniplate; Group ... περισσότερα »
Effect of Er,Cr:YSGG laser on the surface of composite restoratives during in-office tooth bleaching
Abstract The aim of this in vitro study was to investigate the effect of Er,Cr:YSGG laser on the surface roughness and microhardness of various composite restoratives during in-office tooth bleaching. Five highly viscous composite restoratives and three flowable composite restoratives were investigated. Thirty cylindrical specimens of each material were made using Teflon molds. The specimens of each composite were randomly divided into three groups (*n* = 10). Group 1 specimens did not receive bleaching treatment, group 2 received a conventional in-office bleaching treatment, and ... περισσότερα »
The picosecond laser for tattoo removal
Abstract The prevalence of tattoos continues to grow as modern society's stigma towards this form of body art shifts towards greater acceptance. Approximately one third of Americans aged 18–25 and 40 % of Americans aged 26–40 are tattooed. As tattoos continue to rise in popularity, so has the demand for an effective method of tattoo removal such as lasers. The various colors of tattoo inks render them ideal targets for specific lasers using the principle of selective photothermolysis. Traditional laser modalities employed for tattoo removal operate on pulse durations in the nanose...περισσότερα »
Laser and light-based treatments of venous lakes: a literature review
Abstract Venous lake is a benign vascular malformation commonly seen in elderly patients, typically arising in sun-exposed areas of the body. Patients often seek treatment to prevent recurrent bleeding or because they find the lesion cosmetically unacceptable. Venous lake may negatively affect quality of life, due to the cosmetic disfigurement it can create and the resulting psychological distress. Traditional treatments, such as surgical excision, cryosurgery, sclerotherapy, and electrocoagulation, result in varying degrees of success and can cause discomfort. Laser- and light-bas... περισσότερα »
Comparison of the clinical efficacy and safety of retroperitoneal laparoscopic ureterolithotomy and ureteroscopic holmium laser lithotripsy in the treatment of obstructive upper ureteral calculi with concurrent urinary tract infections
Abstract The aim of this study is to compare the clinical efficacy and safety of retroperitoneal laparoscopic ureterolithotomy (RPLU) and ureteroscopic holmium laser lithotripsy (UHLL) as two minimally invasive procedures in managing obstructive upper ureteral calculi with concurrent urinary tract infections (UTI). The retrospective study included 189 patients who underwent unilateral obstructive upper ureteral stones with concurrent UTI from January 2007 to November 2014 at our institution. Patients received RPLU (81 cases) or UHLL (108 cases). All patients received preoperative ... περισσότερα »
Failure strengths of denture teeth fabricated on injection molded or compression molded denture base resins
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Nathan E. Robison, Daranee Tantbirojn, Antheunis Versluis, David R. Cagna Statement of problemDenture tooth fracture or debonding remains a common problem in removable prosthodontics.PurposeThe purpose of this in vitro study was to explore factors determining failure strengths for combinations of different denture tooth designs (shape, materials) and injection or compression molded denture base resins.Material and methodsThree central incisor denture tooth designs were tested: nan... περισσότερα »
Evaluation of various polishing systems and the phase transformation of monolithic zirconia
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Yoon-Hyuk Huh, Chan-Jin Park, Lee-Ra Cho Statement of problemAlthough a well-polished monolithic zirconia surface is essential, insufficient comparative studies on the constituents and efficacy of polishing systems have been conducted.PurposeThe purpose of this in vitro study was to analyze the abrasive constituents and compare the polishing effectiveness of 6 zirconia polishing systems, including their potential influence on the phase transformation of monolithic zirconia.Materia...περισσότερα »
Push-out bond strength of oval versus circular fiber posts irradiated by erbium-doped yttrium aluminum garnet laser
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Ismail Uzun, Cangül Keskin, Damla Özsu, Buğra Güler, Hikmet Aydemir Statement of problemFiber posts in conjunction with resin cements are widely used to provide retention in endodontically treated teeth. The bond strength of restorative materials to root canal dentin is an important issue for the long-term success of restorative procedures. The push-out test is widely used to measure the bonding between the post and radicular dentin.PurposeThe purpose of this in vitro study was to... περισσότερα »
Evaluation of the marginal fit of single-unit, complete-coverage ceramic restorations fabricated after digital and conventional impressions: A systematic review and meta-analysis
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Panagiotis Tsirogiannis, Daniel R. Reissmann, Guido Heydecke Statement of problemIn existing published reports, some studies indicate the superiority of digital impression systems in terms of the marginal accuracy of ceramic restorations, whereas others show that the conventional method provides restorations with better marginal fit than fully digital fabrication. Which impression method provides the lowest mean values for marginal adaptation is inconclusive. The findings from thos...περισσότερα »
Rapid orthodontic extrusion of a subgingivally fractured incisor
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Jean-Philippe Ré, Jean-Daniel Orthlieb from #Dental via xlomafota13 on Inoreader http://ift.tt/22guRpq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Effect of plasma nitriding and titanium nitride coating on the corrosion resistance of titanium
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Xianli Wang, Shizhu Bai, Fang Li, Dongmei Li, Jing Zhang, Min Tian, Qian Zhang, Yu Tong, Zichuan Zhang, Guowei Wang, Tianwen Guo, Chufan Ma Statement of problemThe passive film on the surface of titanium can be destroyed by immersion in a fluoridated acidic medium. Coating with titanium nitride (TiN) may improve the corrosion resistance of titanium.PurposeThe purpose of this in vitro study was to investigate the effect of duplex treatment with plasma nitriding and TiN coating on t... περισσότερα »
Digital immediate dentures treatment: A clinical report of two patients
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Toni Tien Neumeier, Harold Neumeier The use of computer-aided engineering (CAE) and computer-aided design/computer-aided manufacturing (CAD/CAM) technology to fabricate complete dentures was introduced in 2011. Clinical procedures for digital immediate dentures can be identical to those for conventional immediate dentures and can be simplified by leaving all remaining dentition until the time of extraction and denture placement. Through the digital process, a single digital design...περισσότερα »
Immunological defects in severe mucocutaneous HSV-2 infections: response to IFNγ therapy
Publication date: Available online 7 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Peer Arts, Frank L. van de Veerdonk, Robin van der Lee, Martijn A. Langereis, Christian Gilissen, Wendy A.G. van Zelst-Stams, Martijn A. Huynen, Jos W.M. van der Meer, Frank J. van Kuppeveld, Joris A. Veltman, Bart Jan Kullberg, Alexander Hoischen, Mihai G. Netea Teaser Immune defects in dsRNA recognition and IFNγ production underlie susceptibility to severe reactivations with HSV-2. Treatment with recombinant IFNγ shows clinical efficacy, and it should be considered in pa... περισσότερα »
B Cell-Activating Factor as a New Potential Marker in Inflammatory Bowel Disease
Abstract Background B cell-activating factor (BAFF) has been proposed to be a regulator of B cell and T cell immune responses and be associated with inflammatory processes in autoimmunity and B cell malignancies. No study has reported the role of BAFF in inflammatory bowel disease (IBD). Aims The purpose of this study was to investigate expression and concentrations of BAFF in IBD and determine its value to discriminate patients with IBD. Methods Seventy-eight ulcerative colitis (UC) patients, 37 Crohn's disease (CD) patients, 12 irritable bowel syndrome (IBS) patients and 44 hea...περισσότερα »
Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials
Abstract Background Prucalopride, a selective, high-affinity 5-hydroxytryptamine 4 receptor agonist, stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation (CC) in adults. The relative efficacy by gender has not been evaluated. Aim To evaluate the global efficacy and safety of prucalopride 2 mg daily in men and women with CC using data from six large, randomized, controlled clinical trials. Methods Data were combined from six phase 3 and 4, double-blind, randomized, placebo-controlled, parallel-group trials. The primary efficacy e... περισσότερα »
Issue Information - TOC
No abstract is available for this article. from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1qy8T5K via IFTTT
A Footwear–Foot–Knee Computational Platform for Exploring Footwear Effects on Knee Joint Biomechanics
Abstract The purpose of this study was to investigate comprehensive knee joint responses to wedged footwear intervention with lateral inclination angles of 0°, 5°, and 10° at three stance instants in a gait cycle. A footwear–foot–knee finite element model reconstructed from magnetic resonance images of a healthy male subject was validated through a cadaveric experiment and used to predict knee joint loading. The model was driven by the ground reaction force and subject-specific muscle forces to simulate three stance instants, namely the first peak, valley, and second peak of the g... περισσότερα »
Identification of Source Signals by Estimating Directional Index of Phase Coupling in Multivariate Neural Systems
Abstract In the field of biomedical engineering, identification of source signals between multichannel signals is an important technique for measuring the functional connectivity of a variety of brain states and pathological cases such as seizures. It is likely to occur in a weak coupling condition, where the neural actions interact with each other on the level of phase, whereas their amplitudes remain practically uncoupled. Hence, source signal identification by analyzing the directional interactions from a phase-coupled complex neural network is of interest. This study proposes a... περισσότερα »
Smartphones Offer New Opportunities in Clinical Voice Research
Publication date: Available online 7 April 2016 *Source:*Journal of Voice Author(s): C. Manfredi, J. Lebacq, G. Cantarella, J. Schoentgen, S. Orlandi, A. Bandini, P.H. DeJonckere Smartphone technology provides new opportunities for recording standardized voice samples of patients and sending the files by e-mail to the voice laboratory. This drastically improves the collection of baseline data, as used in research on efficiency of voice treatments. However, the basic requirement is the suitability of smartphones for recording and digitizing pathologic voices (mainly characterized by ... περισσότερα »
Word Intelligibility in Multi-voice Singing: The Influence of Chorus Size
Publication date: Available online 7 April 2016 *Source:*Journal of Voice Author(s): Nathaniel Condit-Schultz, David Huron ObjectiveThis study investigated how the intelligibility of sung words is influenced by the number of singers in a choral music style.MethodsThe study used repeated measures factorial. One hundred forty-nine participants listened to recordings of spoken and sung English words and attempted to identify the words. Each stimuli word was sung or spoken in sync by either one, four, eight, sixteen, or twenty-seven members of a high-quality Soprano Alto Tenor Bass (SAT... περισσότερα »
Comparison of the clinical efficacy and safety of retroperitoneal laparoscopic ureterolithotomy and ureteroscopic holmium laser lithotripsy in the treatment of obstructive upper ureteral calculi with concurrent urinary tract infections
Abstract The aim of this study is to compare the clinical efficacy and safety of retroperitoneal laparoscopic ureterolithotomy (RPLU) and ureteroscopic holmium laser lithotripsy (UHLL) as two minimally invasive procedures in managing obstructive upper ureteral calculi with concurrent urinary tract infections (UTI). The retrospective study included 189 patients who underwent unilateral obstructive upper ureteral stones with concurrent UTI from January 2007 to November 2014 at our institution. Patients received RPLU (81 cases) or UHLL (108 cases). All patients received preoperative ... περισσότερα »
Failure strengths of denture teeth fabricated on injection molded or compression molded denture base resins
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Nathan E. Robison, Daranee Tantbirojn, Antheunis Versluis, David R. Cagna Statement of problemDenture tooth fracture or debonding remains a common problem in removable prosthodontics.PurposeThe purpose of this in vitro study was to explore factors determining failure strengths for combinations of different denture tooth designs (shape, materials) and injection or compression molded denture base resins.Material and methodsThree central incisor denture tooth designs were tested: nan... περισσότερα »
Evaluation of various polishing systems and the phase transformation of monolithic zirconia
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Yoon-Hyuk Huh, Chan-Jin Park, Lee-Ra Cho Statement of problemAlthough a well-polished monolithic zirconia surface is essential, insufficient comparative studies on the constituents and efficacy of polishing systems have been conducted.PurposeThe purpose of this in vitro study was to analyze the abrasive constituents and compare the polishing effectiveness of 6 zirconia polishing systems, including their potential influence on the phase transformation of monolithic zirconia.Materia...περισσότερα »
Push-out bond strength of oval versus circular fiber posts irradiated by erbium-doped yttrium aluminum garnet laser
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Ismail Uzun, Cangül Keskin, Damla Özsu, Buğra Güler, Hikmet Aydemir Statement of problemFiber posts in conjunction with resin cements are widely used to provide retention in endodontically treated teeth. The bond strength of restorative materials to root canal dentin is an important issue for the long-term success of restorative procedures. The push-out test is widely used to measure the bonding between the post and radicular dentin.PurposeThe purpose of this in vitro study was to... περισσότερα »
Evaluation of the marginal fit of single-unit, complete-coverage ceramic restorations fabricated after digital and conventional impressions: A systematic review and meta-analysis
Publication date: Available online 7 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Panagiotis Tsirogiannis, Daniel R. Reissmann, Guido Heydecke Statement of problemIn existing published reports, some studies indicate the superiority of digital impression systems in terms of the marginal accuracy of ceramic restorations, whereas others show that the conventional method provides restorations with better marginal fit than fully digital fabrication. Which impression method provides the lowest mean values for marginal adaptation is inconclusive. The findings from thos...περισσότερα »
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