The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies
Publication date: Available online 6 April 2016 *Source:*The Journal of Steroid Biochemistry and Molecular Biology Author(s): Frans Stellaard, Klaus von Bergmann, Thomas Sudhop, Dieter Lütjohann IntroductionRegulation of cholesterol (Chol) homeostasis is controlled by three main fluxes, i.e. intestinal absorption, de novo synthesis (ChS) and catabolism, predominantly as bile acid synthesis (BAS). High serum total Chol and LDL-Chol concentrations in particular are considered risk factors and markers for the development of atherosclerosis. Pharmaceutical treatments to lower serum Chol...περισσότερα »
A portable immunomagnetic cell capture system to accelerate culture diagnosis of bacterial infections
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00291A, Paper Saurabh Singh, Mohita Upadhyay, Jyoti Sharma, Shalini Gupta, Perumal Vivekanandan, Ravikrishnan Elangovan Bacterial infections continue to be a major cause of deaths globally, particularly in resource-poor settings. In the absence of rapid and affordable diagnostic solutions, patients are mostly administered broad spectrum... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PW1UI9 via IFTTT
The importance of lag time extension in determining bacterial resistance to antibiotics
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02649K, Paper Bing Li, Yong Qiu, Hanchang Shi, Huabing Yin It is widely appreciated that widespread antibiotic resistance has significantly reduced the utility of today's antibiotics. Many antibiotics now fail to cure infectious diseases, although they are classified as effective... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PW1UI5 via IFTTT
Correlation between extraction force during tracheal intubation stylet removal and postoperative sore throat
Correlation between extraction force during tracheal intubation stylet removal and postoperative sore throat: [image: gr1.sml] To examine postoperative sore throat resulting from tracheal intubation stylet removal. Highlights - •We investigated risk factors for postoperative sore throat after tracheal extubation with using novelty measurement. - •Postoperative sore throat was significantly related to increased extraction force during stylet removal. - •Especially, extraction force during stylet removal >10.3 N correlated postoperative sore throat. Abstract... περισσότερα »
Editorial Board
Publication date: December 2015 Source:Anthropocene, Volume 12 from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PW4ga6 via IFTTT
A Deficient Diagnosis
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A previously healthy boy, 2 1/2… from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1RFUHBq via IFTTT
Free vitamin D does not vary through the follicular phase of the menstrual cycle
Abstract The importance of vitamin D (25OHD) in general health and reproductive success has been a focus in the setting of the 25OHD deficiency epidemic. However, there are challenges to understanding 25OHD’s effects. The free and bioavailable levels are affected by 25OHD binding protein (DBP) and it is not known how estradiol fluctuations during the… Continue reading Free vitamin D does not vary through the follicular phase of the menstrual cycle
A Deficient Diagnosis
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A previously healthy boy, 2 1/2… from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1RFUHBq via IFTTT
IFC (Journal of Ethnopharmacology)
Publication date: 26 May 2016 Source:Journal of Ethnopharmacology, Volume 184 from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/25MOWIs via IFTTT
Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Toshiaki Suzuki, Keisuke Miyamoto, Naomi Yokoyama, Mayuko Sugi, Akina Kagioka, Yuka Kitao, Takumi Adachi, Masahiro Ohsawa, Hajime Mizukami, Toshiaki Makino Ethnopharmacological relevanceProcessed aconite root (PA, the root of Aconitum carmichaeli, Ranunculaceae) is a crude drug used in traditional Chinese or Japanese kampo medicine to… Continue reading Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain
The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Guo Ai, Zheng-Ming Huang, Qing-Chuan Liu, Yan-Quan Han, Xi Chen Ethnopharmacology relevanceWater dropwort [Oenanthe javanica (O. javanica)] is an aquatic perennial herb cultivated in East Asian countries. It has been popularly used in traditional Chinese medicine which is beneficial for the treatment of many… Continue reading The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine
Testing the absorption of the extracts of Coreopsis tinctoria Nutt. in the intestinal canal in rats using an Ussing chamber
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Jian Wang, Guzhalinuer Aierken, Xinxia Li, Linlin Li, Xinmin Mao Ethnopharmacological relevanceCoreopsis tinctoria Nutt mainly distributed in Hetian region of Xinjiang at an altitude of 3000m, which is used as Uyghur traditional medicine because of its clearing heat, promoting circulation and removing toxicity and… Continue reading Testing the absorption of the extracts of Coreopsis tinctoria Nutt. in the intestinal canal in rats using an Ussing chamber
Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Toshihisa Onoda, Wei Li, Tatsunori Sasaki, Megumi Miyake, Koji Higai, Kazuo Koike Ethnopharmacological relevanceMasiningan is a traditional medicine consisting of six crude drugs that have been used for treating constipation and diabetes mellitus in both Japan and China. Masiningan has been reported to have… Continue reading Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan
Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Xie Zhang, Chao-Yue Sun, Yong-Bin Zhang, Hui-Zhen Guo, Xue-Xuan Feng, Shao-Zhong Peng, Jie Yuan, Rong-Bo Zheng, Wei-Ping Chen, Zi-Ren Su, Xiao-Dan Huang Ethnopharmacological relevanceKegan Liyan oral liquid (KGLY), a Chinese prescription modified from classic formulas Yin-Qiao-San (from TCM classic Wenbing Tiaobian) and Shen-Jie-San (first… Continue reading Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathwa...περισσότερα »
Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury
[IMMUNE REGULATION] by Ritzel, R. M., Crapser, J., Patel, A. R., Verma, R., Grenier, J. M., Chauhan, A., Jellison, E. R., McCullough, L. D. via The Journal of Immunology current issue Aging is associated with an increase in basal inflammation in the CNS and an overall decline in cognitive function and poorer recovery following injury. Growing evidence suggests that leukocyte recruitment to the CNS is also increased with normal aging, but, to date, no systematic evaluation of these age-associated leukocytes has been performed. In this work, the effect of aging on CNS leukocyte recrui... περισσότερα »
Peripheral blood mononuclear cell gene expression testing and the heterogeneity of T-cell–mediated drug reaction with eosinophilia and systemic symptoms syndrome
Peripheral blood mononuclear cell gene expression testing and the heterogeneity of T-cell–mediated drug reaction with eosinophilia and systemic symptoms syndrome: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threatening adverse drug hypersensitivity reaction.1,2 Not uncommonly, the reaction occurs in hospitalized patients who may have been placed on multiple new medications, making identification of the offending agent extremely difficult. In these instances, a physician can avoid all new medications or those most likely to ha... περισσότερα »
Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota
Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota via Allergy and Clinical Immunology Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jonathan M. Mansbach, Kohei Hasegawa, David M. Henke, Nadim J. Ajami, Joseph F. Petrosino, Chad A. Shaw, Pedro A. Piedra, Ashley F. Sullivan, Janice A. Espinola, Carlos A. Camargo
Plasmin is a natural trigger for bradykinin production in hereditary angioedema with Factor XII mutations
Plasmin is a natural trigger for bradykinin production in hereditary angioedema with Factor XII mutations via Allergy and Clinical Immunology Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Steven de Maat, Jenny Björkqvist, Chiara Suffritti, Chantal P. Wiesenekker, Willem Nagtegaal, Arnold Koekman, Sanne van Dooremalen, Gerard Pasterkamp, Philip G. de Groot, Marco Cicardi, Thomas Renné, Coen Maas BackgroundPatients with angioedema develop unpredictable attacks of tissue swelling in which bradykinin is implicated. Several dis... περισσότερα »
Clinical and histopathologic overlap between subcutaneous panniculitis-like T-cell lymphoma with systemic features and small cell CD8+ ALK+ systemic anaplastic large cell lymphoma with cutaneous involvement
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Histopathologically malignant solitary fibrous tumor of the skin: a report of an unusual case
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Mast Cell-Mediated Passive Cutaneous Anaphylaxis and Passive Systemic Anaphylaxis
Humanized Mouse Model of via Allergy and Clinical Immunology Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Paul J. Bryce, Rustom Falahati, Laurie Kenney, John Leung, Christopher Bebbington, Nenad Tomasevic, Rebecca A. Krier, Chia-Lin Hsu, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm BackgroundMast cells are a critical component of allergic responses in humans, and animal models that allow the in vivo investigation of their contribution to allergy and evaluation of new human-specific therapeutics are urgently need...περισσότερα »
Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis
Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis via Allergy and Clinical Immunology Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Alexander S. Kim, Taylor A. Doherty, Maya R. Karta, Sudipta Das, Rachel Baum, Peter Rosenthal, Andrew Beppu, Marina Miller, Richard Kurten, David H. Broide
Clinical and histopathologic overlap between subcutaneous panniculitis-like T-cell lymphoma with systemic features and small cell CD8+ ALK+ systemic anaplastic large cell lymphoma with cutaneous involvement
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
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Histopathologically malignant solitary fibrous tumor of the skin: a report of an unusual case
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1q8HIgY via IFTTT
Clinical and histopathologic overlap between subcutaneous panniculitis-like T-cell lymphoma with systemic features and small cell CD8+ ALK+ systemic anaplastic large cell lymphoma with cutaneous involvement
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Histopathologically malignant solitary fibrous tumor of the skin: a report of an unusual case
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1q8HIgY via IFTTT
Long-term impact of sewage irrigation on soil properties and assessing risk in relation to transfer of metals to human food chain
Abstract A case study was undertaken to assess the risk of sewage-irrigated soils in relation to the transfer of trace elements to rice and wheat grain. For this purpose, peri-urban agricultural lands under the Keshopur Effluent Irrigation Scheme (KEIS) of Delhi were selected. These agricultural lands have been receiving irrigation through sewage effluents since 1979. Sewage effluent, groundwater, soil, and plant (rice and wheat grain) samples were collected with GPS coordinates from this peri-urban area. Under wheat crop, sewage irrigation for four decades resulted into a signific...περισσότερα »
Bacterial strains isolated from river water having the ability to split alcohol ethoxylates by central fission
Abstract Alcohol ethoxylates (AE) are a major component of the surfactant stream discharged into surface water. The "central fission" of AE with the formation of poly(ethylene glycols) (PEG) is considered to be the dominant biodegradation pathway. However, information as to which bacterial strains are able to perform this reaction is very limited. The aim of this work was to establish whether such an ability is unique or common, and which bacterial strains are able to split AE used as a sole source of organic carbon. Four bacterial strains were isolated from river water and were i... περισσότερα »
Body burden of persistent organic pollutants on hypertension: a meta-analysis
Abstract Except the known risk factors for hypertension, several studies have suggested that exposure to persistent organic pollutants (POPs), endocrine disrupting chemicals, could be associated with an increased risk of hypertension. In this study, we performed a meta-analysis to summarize the existing epidemiological studies to investigate the association between POPs concentration and risk of hypertension. Based on comprehensive literature search results (PubMed, EMBASE, and KoreaMed), a meta-analysis of 11 articles was performed using a random-effects model. While we observed ... περισσότερα »
Reply to the commentary by Law and Han: the importance of suitable GC-MS date processing and analysis for plant and environmental metabolomics, with references to: changes in the abundance of sugars and sugar-like compounds in tall fescue ( Festuca arundinacea ) due to growth in naphthalene-treated sand
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Use of iron and bio-oil wastes to produce highly dispersed Fe/C composites for the photo-Fenton reaction
Abstract This work describes the synthesis, characterization, and application of an active heterogeneous photo-Fenton system obtained from two different wastes, i.e., laterite (an iron mining waste) and the acid aqueous fraction (AAF) from bio-oil production. AAF with high acidity (ca. 3 molH+ L−1) and organic concentration (25 wt.%) obtained from biomass flash pyrolysis was used for the efficient extraction of Fe3+ from laterite waste. After extraction, the mixture Fe3+/AAF was dried and treated at different temperatures, i.e., 500, 650, and 800 °C, to obtain Fe/C reactive compos... περισσότερα »
Preliminary characterization of biosurfactant produced by a PAH-degrading Paenibacillus sp. under thermophilic conditions
Abstract The capacities of a biosurfactant producing and polycyclic aromatic hydrocarbon (PAH) utilizing bacterium, namely, strain 1C, isolated from an Algerian contaminated soil, were investigated. Strain 1C belonged to the *Paenibacillus* genus and was closely related to the specie *Paenibacillus popilliae*, with 16S rRNA gene sequence similarity of 98.4 %. It was able to produce biosurfactant using olive oil as substrate. The biosurfactant production was shown by surface tension (32.6 mN/m) after 24 h of incubation at 45 °C and 150 rpm. The biosurfactant(s) retained its propert... περισσότερα »
Ecological risk assessment of heavy metal (HM) pollution in the ambient air using a new bio-indicator
Abstract The aim of this descriptive-analytical study was to measure the concentration of heavy metals (HMs) in the leaf and bark of *Ulmus carpinifolia* as new biological indicators, and the ecological risk assessment of these metals in the ambient air. To achieve these goals, 48 sampling locations were selected in the city and concentration of four HMs—zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd)—was measured in the mentioned indicator using atomic absorption spectroscopy method. After this, ecological risk assessment, source appointment, and spatial distribution were con... περισσότερα »
Simultaneous GC-MS determination of seven phthalates in total and migrated portions of paper cups
Abstract Phthalate acid esters are widely used as plasticizers to impart plastic flexibility in various industrial applications. In this study, the content of seven phthalates, dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), di-(2-ethylhexyl) adipate (DEHA), di-2-ethylhexyl phthalate (DEHP), di-n-octyl phthalate (DNOP), di-isononyl phthalate (DINP), and di-isodecyl phthalate (DIDP) were determined in paper cups using gas chromatography–mass spectrometry (GC-MS). In addition, the potential migration of these seven phthalates from paper cups into various food stimulants under... περισσότερα »
Impact of WWII dumpsites on Saipan (CNMI): heavy metal status of soils and sediments
Abstract A number of dumpsites occur on the island of Saipan and in the surrounding coastal waters. Many of these sites date back to the immediate post WWII clean-up period and contain a variety of wartime wastes. Metallic debris is generally the most visible waste material and commonly includes bomb fragments, artillery shells, bullets, and other military hardware. In this investigation, we examined the heavy metal status of soils from around several of these dumpsites and in any obvious drainage pathways leading from them to the coast. Sediments were also taken for analysis from ...περισσότερα »
Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes , using a metabolomics approach
Abstract In this study, the metabolic effects of waterborne exposure of medaka (*Oryzias latipes*) to nominal concentrations of 20 (L group) and 2000 μg/L (H group) 2,4-dichlorophenol (DCP) were examined using a gas chromatography/mass spectroscopy (GC/MS) metabolomics approach. A principal component analysis (PCA) separated the L, H, and control groups along PC1 to explain the toxic effects of DCP at 24 h of exposure. Furthermore, the L and H groups were separated along PC1 at 96 h on the PCA score plots. These results suggest that the effects of DCP depended on exposure concentra... περισσότερα »
Organic and inorganic amendment application on mercury-polluted soils: effects on soil chemical and biochemical properties
Abstract On the basis of a previous study performed in our laboratory, the use of organic and inorganic amendments can significantly modify the Hg mobility in soil. We have compared the effectiveness of organic and inorganic amendments such as digestate and fly ash, respectively, reducing the Hg mobility in Chernozem and Luvisol soils differing in their physicochemical properties. Hence, the aim of this work was to compare the impact of digestate and fly ash application on the chemical and biochemical parameters in these two mercury-contaminated soils in a model batch experiment. ...περισσότερα »
Additional disturbances as a beneficial tool for restoration of post-mining sites: a multi-taxa approach
Abstract Open interior sands represent a highly threatened habitat in Europe. In recent times, their associated organisms have often found secondary refuges outside their natural habitats, mainly in sand pits. We investigated the effects of different restoration approaches, i.e. spontaneous succession without additional disturbances, spontaneous succession with additional disturbances caused by recreational activities, and forestry reclamation, on the diversity and conservation values of spiders, beetles, flies, bees and wasps, orthopterans and vascular plants in a large sand pit i... περισσότερα »
Photodegradation of gemfibrozil in aqueous solution under UV irradiation: kinetics, mechanism, toxicity, and degradation pathways
Abstract The lipid regulator gemfibrozil (GEM) has been reported to be persistent in conventional wastewater treatment plants. This study investigated the photolytic behavior, toxicity of intermediate products, and degradation pathways of GEM in aqueous solutions under UV irradiation. The results demonstrated that the photodegradation of GEM followed pseudo-first-order kinetics, and the pseudo-first-order rate constant was decreased markedly with increasing initial concentrations of GEM and initial pH. The photodegradation of GEM included direct photolysis via 3GEM* and self-sensi... περισσότερα »
Anomalous distribution of fluoride and phosphorus forms in surface sediments along eastern Egyptian Mediterranean Sea coast
Abstract The study focused on the distribution of fluoride, total phosphorus, and four phosphorus fractions in some sites along the Egyptian Mediterranean Sea coast. The geochemical parameters and textures of 30 surficial sediment samples from six sectors were determined. The sediment's geochemical parameters (total carbonates (TCO3) and total organic carbon (TOC), exchangeable and carbonate-associated phosphorus (Pex), iron- and aluminum-associated phosphorus (POH), calcium-associated phosphate/apatite (PHCl), residual phosphorus (PR), total phosphorus (TP), calcium (Cas), magnes... περισσότερα »
Ligelizumab versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses via Allergy and Clinical Immunology Publication date: Available online 7 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Gail M. Gauvreau, Jonathan P. Arm, Louis-Philippe Boulet, Richard Leigh, Donald W. Cockcroft, Beth E. Davis, Irvin Mayers, J. Mark FitzGerald, Barbro Dahlen, Kieran J. Killian, Michel Laviolette, Christopher Carlsten, Nikolaos Lazarinis, Richard M. Watson, Joanne Milot, Veronica Swystun, Mirand...περισσότερα »
Cow’s milk elimination diet in pediatric eosinophilic esophagitis
IgE antibodies and response to cow’s milk elimination diet in pediatric eosinophilic esophagitis via Allergy and Clinical Immunology Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Elizabeth A. Erwin, Patrice G. Kruszewski, John M. Russo, Alexander J. Schuyler, Thomas A.E. Platts-Mills TeaserMilk is a common cause of eosinophilic esophagitis. Allergy testing does not predict response to dietary therapy. In this study, patients with low or undetectable IgE antibodies to milk achieved histologic remission with milk eliminati... περισσότερα »
Crotoxin (cytotoxic PLA(2), NSC-624244)
Clin Cancer Res. Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA(2), NSC-624244) in patients with advanced cancer. Cura JE1, Blanzaco DP, Brisson C, Cura MA, Cabrol R, Larrateguy L, Mendez C , Sechi JC, Silveira JS, Theiller E, de Roodt AR, Vidal JC. Author information - 1Department of Medical Oncology Hospital San Martin, Paraná, Entre Rios, Argentina. Abstract A Phase I clinical trial was performed on patients with solid tumors refractory to conventional therapy. Crotoxin was administered i.m. for 30 consecutive days at doses ranging from 0.03 to 0.22 mg/m(2). Pa... περισσότερα »
Eosinophilic esophagitis after desensitization to dust mites with sublingual immunotherapy
Eosinophilic esophagitis after desensitization to dust mites with sublingual immunotherapy: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder characterized by esophageal dysfunction and eosinophilic infiltration of the esophageal mucosa. The disease affects both children and adults, with a prevalence of 5 per 10,000 inhabitants in Europe and the United States.1 Childhood cases are generally diagnosed between 5 and 10 years of age and adult cases between 30 and 40 years of age. The male-female sex ratio is 3:1 in a published series.2 The symptoms vary according to the...περισσότερα »
Cancers, Vol. 8, Pages 44: Expression of Concern: Takai, N. and Narahara, H. Epigenetic Therapy in Human Choriocarcinoma. Cancers 2010, 2, 1683–1688
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
We wish to make readers aware that text in [1] has been taken from other publications by the same author. […] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RQYSXR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Rapid Down-Regulation of Glucocorticoid Gene Expression in the Dentate Gyrus after Acute Stress in vivo: Role of DNA Methylation and microRNA Activity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Background: Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. This work investigates the molecular mechanisms underpinning stress-induced changes in hippocampal GR mRNA levels in vivo.Methods: Male Wistar rats were killed either under baseline conditions or […]
Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Kisspeptins and their receptors are potent regulators of the gonadotropic axis. Kisspeptin neurons are found mainly in the hypothalamic arcuate nucleus and the anteroventral periventricular nucleus. However, there is also a third population of kisspeptin neurons located in the amygdala. We used fluorescence immunohistochemistry to quantify and localize the amygdala kisspeptin neurons and to reveal […]
Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Publication date: Available online 7 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Sébastien Imbert, Priscillia Bresler, Alexandre Boissonnas, Lauraine Gauthier, Laëtitia Souchet, Madalina Uzunov, Véronique Leblond, Dominique Mazier, Stéphanie Nguyen, Arnaud Fekkar BackgroundNeutrophils are key effectors against the widely distributed mold Aspergillus fumigatus, which is a major threat for immunocompromised patients including allogenic […]
Immunological defects in severe mucocutaneous HSV-2 infections: response to IFNγ therapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Publication date: Available online 7 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Peer Arts, Frank L. van de Veerdonk, Robin van der Lee, Martijn A. Langereis, Christian Gilissen, Wendy A.G. van Zelst-Stams, Martijn A. Huynen, Jos W.M. van der Meer, Frank J. van Kuppeveld, Joris A. Veltman, Bart Jan Kullberg, Alexander Hoischen, Mihai […]
Functional changes in gut microbiota during haematopoietic stem cell transplantation for severe combined immunodeficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jonathan P. Lane, Christopher J. Stewart, Stephen P. Cummings, Andrew R. Gennery Teaser Metabolite profiles of gut microbiota in SCID show gradual change from a pre- to post-transplant profile. There are predicted fluctuations in microbiota bacterial motility and membrane transport functions […]
Hematopoietic Stem Cell Transplantation Outcomes for 11 Patients with Dedicator of Cytokinesis 8 (DOCK8) Deficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Waleed Al-Herz, Julia I. Chu, Jet van der Spek, Raj Raghupathy, Michel J. Massaad, Sevgi Keles, Catherine M. Biggs, Lucinda Cockerton, Janet Chou, Ghassan Dbaibo, Scott A. Elisofon, Rima Hanna-Wakim, Heung Bae Kim, Leslie E. Lehmann, Douglas R. McDonald, Luigi D. […]
IgE antibodies and response to cow’s milk elimination diet in pediatric eosinophilic esophagitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Elizabeth A. Erwin, Patrice G. Kruszewski, John M. Russo, Alexander J. Schuyler, Thomas A.E. Platts-Mills Teaser Milk is a common cause of eosinophilic esophagitis. Allergy testing does not predict response to dietary therapy. In this study, patients with low or undetectable […]
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 7 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Gail M. Gauvreau, Jonathan P. Arm, Louis-Philippe Boulet, Richard Leigh, Donald W. Cockcroft, Beth E. Davis, Irvin Mayers, J. Mark FitzGerald, Barbro Dahlen, Kieran J. Killian, Michel Laviolette, Christopher Carlsten, Nikolaos Lazarinis, Richard M. Watson, Joanne Milot, Veronica Swystun, Miranda Bowen., […]
Food-specific IgG4 is associated with eosinophilic esophagitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Benjamin L. Wright, Mike Kulis, Rishu Guo, Kelly A. Orgel, W. Asher Wolf, A. Wesley Burks, Brian P. Vickery, Evan S. Dellon Teaser Elevated total and food-specific IgG4 are associated with active EoE and decline in response to dietary elimination. Food-specific […]
Why Ambient Ultrafine and Engineered Nanoparticles Should Receive Special Attention for Possible Adverse Health Outcomes in Humans
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Ning Li, Steve Georas, Neil Alexis, Patricia Fritz, Tian Xia, Marc A. Williams, Elliott Horner, Andre Nel Ultrafine particles are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of ultrafine particles are diesel exhaust particles, products of cooking, […]
The pruritus- and TH2-associated cytokine Interleukin-31 promotes growth of sensory nerves
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Micha Feld, Richard Garcia, Jörg Buddenkotte, Shintaro Katayama, Katherine Lewis, Gareth Muirhead, Peter Hevezi, Kristin Plesser, Holger Schrumpf, Kaarel Krjutshkov, Olga Sergeeva, Hans Werner Müller, Sophia Tsoka, Juha Kere, Stacey R. Dillon, Martin Steinhoff, Bernhard Homey BackgroundPruritus is a cardinal symptom […]
Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Alexander S. Kim, Taylor A. Doherty, Maya R. Karta, Sudipta Das, Rachel Baum, Peter Rosenthal, Andrew Beppu, Marina Miller, Richard Kurten, David H. Broide from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MUtPNV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel […]
Identification of a new locus at 16q12 associated with time-to-asthma onset
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Chloé Sarnowski, Pierre-Emmanuel Sugier, Raquel Granell, Debbie Jarvis, Marie-Hélène Dizier, Markus Ege, Medea Imboden, Catherine Laprise, Elza K. Khusnutdinova, Maxim B. Freidin, William O.C. Cookson, Miriam Moffatt, Mark Lathrop, Valérie Siroux, Ludmila M. Ogorodova, Alexandra S. Karunas, Alan James, Nicole M. […]
Humanized Mouse Model of Mast Cell-Mediated Passive Cutaneous Anaphylaxis and Passive Systemic Anaphylaxis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul J. Bryce, Rustom Falahati, Laurie Kenney, John Leung, Christopher Bebbington, Nenad Tomasevic, Rebecca A. Krier, Chia-Lin Hsu, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm BackgroundMast cells are a critical component of allergic responses in humans, and animal models […]
Plasmin is a natural trigger for bradykinin production in hereditary angioedema with Factor XII mutations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 6 April 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Steven de Maat, Jenny Björkqvist, Chiara Suffritti, Chantal P. Wiesenekker, Willem Nagtegaal, Arnold Koekman, Sanne van Dooremalen, Gerard Pasterkamp, Philip G. de Groot, Marco Cicardi, Thomas Renné, Coen Maas BackgroundPatients with angioedema develop unpredictable attacks of tissue swelling in which bradykinin […]
Serum periostin is associated with type 2 immunity in severe asthma
Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Mats W. Johansson, Michael D. Evans, Gina M. Crisafi, Cécile T.J. Holweg, John G. Matthews, Nizar N. Jarjour from #ENT via xlomafota13 on Inoreader http://ift.tt/23knb7Q via IFTTT
Adenosine deaminase type 2 deficiency (ADA2) masquerading as GATA2 deficiency: successful hematopoietic stem cell transplantation
Publication date: Available online 6 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Amy P. Hsu, Robert R. West, Katherine R. Calvo, Jennifer Cuellar-Rodriguez, Mark Parta, Susan J. Kelly, Nancy J. Ganson, Michael S. Hershfield, Steven M. Holland, Dennis D. Hickstein Teaser Whole exome sequencing of a 20 yo woman with apparent GATA2 deficiency identified homozygous CECR1 null alleles encoding adenosine deaminase 2 (ADA2); ADA2 deficiency can mimic GATA2 deficiency; haploidentical transplantation is curative in both conditions. from #ENT via xlomafota13 on...περισσότερα »
Comparing auditory steady-state responses amplitude evoked by simultaneous air- and bone-conducted stimulation in newborns
10.3109/14992027.2016.1159341<br>Alejandro Torres-Fortuny from #ENT via xlomafota13 on Inoreader http://ift.tt/22eISUz via IFTTT
Speech recognition outcomes following bilateral cochlear implantation in adults aged over 50 years old
10.3109/14992027.2016.1152403<br>Isabelle Boisvert from #ENT via xlomafota13 on Inoreader http://ift.tt/1UKaPo8 via IFTTT
Adenoma pleomorfo parotídeo gigante
Publication date: Available online 6 April 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Christian E. Calvo-Henriquez, Andrea Telmo-Mella, Cristina Dios-Loureiro, Carlos Martín-Martín from #ENT via xlomafota13 on Inoreader http://ift.tt/1qvKiOR via IFTTT
Retraso en el diagnóstico de sordera infantil: el valor de los falsos negativos en el Programa de Detección Precoz de Hipoacusias Neonatales
Publication date: Available online 6 April 2016 *Source:*Acta Otorrinolaringológica Española Author(s): María C. Martínez-Pacheco, Luis Ferrán de la Cierva, Francisco J. García-Purriños IntroducciónA pesar de su importancia, la existencia de falsos negativos (pacientes a los que se les dice que oyen bien, pero en realidad son hipoacúsicos) no suele ser evaluada en los programas de detección precoz de hipoacusia. El objetivo de este estudio es determinar las variables que pueden a llevar a un retraso diagnóstico, en especial la existencia de falsos negativos así como la falta de regi... περισσότερα »
Does skull morphology constrain bone ornamentation? A morphometric analysis in the Crocodylia
Abstract Previous quantitative assessments of the crocodylians' dermal bone ornamentation (this ornamentation consists of pits and ridges) has shown that bone sculpture results in a gain in area that differs between anatomical regions: it tends to be higher on the skull table than on the snout. Therefore, a comparative phylogenetic analysis within 17 adult crocodylian specimens representative of the morphological diversity of the 24 extant species has been performed, in order to test if the gain in area due to ornamentation depends on the skull morphology, i.e. shape and size. Qua... περισσότερα »
Does skull morphology constrain bone ornamentation? A morphometric analysis in the Crocodylia
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Abstract Previous quantitative assessments of the crocodylians' dermal bone ornamentation (this ornamentation consists of pits and ridges) has shown that bone sculpture results in a gain in area that differs between anatomical regions: it tends to be higher on the skull table than on the snout. Therefore, a comparative phylogenetic analysis within 17 adult crocodylian specimens representative of the morphological diversity of the 24 extant species has been performed, in order to test if the gain in area due to ornamentation depends on the skull morphology, i.e. shape and size. Qua... περισσότερα »
Isolation and Culture of Single Cell Types from Rat Liver
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
There have been few reports on the simultaneous isolation of multiple liver cell populations thus far. As such, this study was aimed at establishing a protocol for the simultaneous separation of hepatocytes (HCs), hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs) from the rat liver and assessing the in vitro culture of these cells. Single-cell suspensions from the liver were obtained by ethylene glycol tetraacetic acid/collagenase perfusion. After low-speed centrifugal separation of HCs, pronase was added to the nonparenchymal cell f... περισσότερα »
Crotoxin: a novel allergen to occupational anaphylaxis
Crotoxin: a novel allergen to occupational anaphylaxis: Anaphylaxis is an immediate, serious, and potentially fatal systemic hypersensitivity reaction.1 The signs and symptoms result from the release of chemical mediators from mast cells and basophils, the mechanism of which may or may not be mediated by the immune system. The initial manifestation of anaphylaxis includes symptoms such as urticaria, angioedema, acute rhinoconjunctivitis, bronchospasm, hypotension, sneezing, itching and hyperemia of the nose, and conjunctival mucosa. Severe cases may evolve into shock, respiratory fa... περισσότερα »
Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular and dermatological systems.
Vogt-Koyanagi-Harada Syndrome: Perspectives for Immunogenetics, Multimodal Imaging and Therapeutic Options via Autoimmunity Reviews Publication date: Available online 7 April 2016 *Source:*Autoimmunity Reviews Author(s): Sukhum Silpa-archa, Narumol Silpa-archa, Janine M. Preble, C. Stephen Foster Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inf... περισσότερα »
Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo
Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo: Abstract Background Besides allergens, pollen release bioactive, low molecular weight compounds that modulate and stimulate allergic reactions. Clinical relevance of these substances hasn't been investigated to date. Objective To elucidate the effect of a non-allergenic, low molecular weight factors from aqueous birch pollen extracts (Bet-APE<3kDa) on the human allergic immune response *in vivo*. Methods Birch and grass pollen allergic individuals underwent skin prick testing with all... περισσότερα »
Vogt-Koyanagi-Harada Syndrome: Perspectives for Immunogenetics, Multimodal Imaging and Therapeutic Options
Publication date: Available online 7 April 2016 *Source:*Autoimmunity Reviews Author(s): Sukhum Silpa-archa, Narumol Silpa-archa, Janine M. Preble, C. Stephen Foster Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inflammation of the choroidal layer. This phenomenon usually leads to diffuse inflammatory conditions throughout most parts of eye be... περισσότερα »
Zika virus, autoimmunity and microcephaly: other things for consideration
Publication date: Available online 7 April 2016 *Source:*Autoimmunity Reviews Author(s): Viroj Wiwanitkit from #ENT via xlomafota13 on Inoreader http://ift.tt/23klsiS via IFTTT
Reply concerning the article " Zika virus and autoimmunity: from mycrocephaly to Guillain-Barré syndrome, and beyond."
Publication date: Available online 6 April 2016 *Source:*Autoimmunity Reviews Author(s): Darja Kanduc from #ENT via xlomafota13 on Inoreader http://ift.tt/1VzHNX6 via IFTTT
Reflectance Measures from Infant Ears with Normal Hearing and Transient Conductive Hearing Loss.
Objective: The objective is to develop methods to utilize newborn reflectance measures for the identification of middle-ear transient conditions (e.g., middle-ear fluid) during the newborn period and ultimately during the first few months of life. Transient middle-ear conditions are a suspected source of failure to pass a newborn hearing screening. The ability to identify a conductive loss during the screening procedure could enable the referred ear to be either (1) cleared of a middle-ear condition and recommended for more extensive hearing assessment as soon as possible, or (2) su... περισσότερα »
Reflectance Measures from Infant Ears with Normal Hearing and Transient Conductive Hearing Loss.
Objective: The objective is to develop methods to utilize newborn reflectance measures for the identification of middle-ear transient conditions (e.g., middle-ear fluid) during the newborn period and ultimately during the first few months of life. Transient middle-ear conditions are a suspected source of failure to pass a newborn hearing screening. The ability to identify a conductive loss during the screening procedure could enable the referred ear to be either (1) cleared of a middle-ear condition and recommended for more extensive hearing assessment as soon as possible, or (2) su... περισσότερα »
Reflectance Measures from Infant Ears with Normal Hearing and Transient Conductive Hearing Loss.
Objective: The objective is to develop methods to utilize newborn reflectance measures for the identification of middle-ear transient conditions (e.g., middle-ear fluid) during the newborn period and ultimately during the first few months of life. Transient middle-ear conditions are a suspected source of failure to pass a newborn hearing screening. The ability to identify a conductive loss during the screening procedure could enable the referred ear to be either (1) cleared of a middle-ear condition and recommended for more extensive hearing assessment as soon as possible, or (2) su... περισσότερα »
Patterns of Long-term Hearing Loss in Hearing Preservation Cochlear Implant Surgery.
Objective: To describe patterns of hearing loss in patients with low-frequency residual hearing after cochlear implantation. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Cochlear implant candidates with immediate postoperative residual low-frequency hearing. Interventions: Hybrid or traditional cochlear implant. Main Outcome Measure: Audiograms to measure postoperative hearing. Results: Of the 166 patients reviewed, 17 ears met the inclusion criteria. The age ranged from 3 years 2 months to 86 years. Etiology was unknown (n = 6), presbycusis... περισσότερα »
Cochlear Implant Outcomes in Cochlea Nerve Aplasia and Hypoplasia.
Objective: To assess cochlear implant (CI) outcomes, and factors affecting outcomes, for children with aplasia/ hypoplasia of the cochlea nerve. We also developed a new grading system for the nerves of the internal auditory meatus (IAM) and cochlea nerve classification. Study Design: Retrospective patient review. Setting: Tertiary referral hospital and cochlear implant program. Patients: Children 0 to 16 years inclusive with a CI who had absent/hypoplastic cochlea nerve on magnetic resonance imaging (MRI). Intervention: Cochlear implant. Main Outcome Measures: MRI, trans-tympanic el... περισσότερα »
Vascular and Neuroepithelial Histopathology of the Saccule in Humans With Diabetes Mellitus.
Hypothesis: This study aimed to determine if there are quantitative differences in the neuroepithelium and microvasculature of the saccule between subjects with and without diabetes mellitus (DM). Background: Histopathologic changes that may underlie the association between DM and vestibular dysfunction have not been characterized in humans. Methods: Human temporal bones (HTBs) from 39 subjects with DM (n = 16 type I DM [T1DM], n = 23 type II DM [T2DM]) were compared with 40 group age-matched controls. Vessel wall thickness was measured from the saccular arteriole. Type I and type I...περισσότερα »
Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study.
Hypothesis: We hypothesized that, in archived human temporal bone samples from patients with systemic lupus erythematosus (SLE), a pathologic condition exists in the stria vascularis and cochlear hair cells. Background: Sensorineural hearing loss is a common feature in SLE patients. However, the pathophysiologic mechanism of cochlear dysfunction is unclear. Methods: We examined 15 temporal bone samples from 8 SLE patients, along with 17 samples from 10 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and e... περισσότερα »
Health-related Quality of Life of Individuals With Neurofibromatosis Type 2: Results From the NF2 Natural History Study.
Objective: To explore health-related quality of life (HRQoL) reported by individuals with neurofibromatosis type 2 (NF2) and to assess for correlations between HRQoL and objective measures of disease manifestations. Study Design: Prospective observational study. Setting: Seven international NF2 centers. Subjects: Eighty-one individuals with NF2, 73 adults (>18 years) and 8 children/adolescents (10-17 years). Outcome Measures: Quality of life was measured by Short Form-36 (SF-36) norm-based scores. Objective clinical measures were hearing (categorized by word-recognition scores), fac...περισσότερα »
Click Stimulus Electrocochleography Versus MRI With Intratympanic Contrast in Meniere's Disease: A Systematic Review.
Objective: To evaluate the diagnostic value of electrocochleography compared with magnetic resonance imaging (MRI) with intratympanic gadolinium administration to diagnose endolymphatic hydrops in patients with Meniere's disease. Data Sources: An electronic search was performed in the PubMed, EMBASE, and Cochrane databases on September 15, 2015. A systematic search was conducted. Articles were included if written in English, Dutch, German, or French language. Study Selection: Original studies reporting on the diagnostic value of electrocochleography compared with MRI with intratympa...περισσότερα »
Craniocervical Pneumatization: Estimation of Prevalence and Imaging of Treatment Response.
Objective: Estimate the prevalence of craniocervical pneumatization (CCP) and describe successful treatment of this condition with clinical and radiologic correlation. Patients: Individuals with documented CCP on computed tomography (CT). Intervention(s): CT scans of the head, temporal bone, face, neck, and cervical spine. Cessation of habitual Valsalva maneuver (VM) and insertion of pressure-equalization (PE) tubes. Main Outcome Measure: The prevalence of CCP on CT examinations performed during two decades in a large academic healthcare system. Documentation of symptomatic and imag... περισσότερα »
Diffusion-weighted Magnetic Resonance Imaging as a Novel Imaging Modality in Assessing Treatment Response in Necrotizing Otitis Externa.
Objective: To report our initial experience of diffusion-weighted magnetic resonance imaging (DW-MRI) as a novel imaging tool for assessing and monitoring treatment response in necrotizing otitis externa (NOE). Patients: Seven adults with a diagnosis of NOE on both clinical and computed tomography (CT) criteria who were subsequently monitored with at least two echoplanar DW-MRI investigations were included in this retrospective longitudinal observational study. Intervention: Patients underwent magnetic resonance imaging (MRI), including echoplanar diffusion-weighted sequences, withi...περισσότερα »
Effect of Round Window Reinforcement on Hearing: A Temporal Bone Study With Clinical Implications for Surgical Reinforcement of the Round Window.
Hypothesis: Round window reinforcement leads to conductive hearing loss. Background: The round window is stiffened surgically as therapy for various conditions, including perilymphatic fistula and superior semicircular canal dehiscence. Round window reinforcement reduces symptoms in these patients. However, it also reduces fluid displacement in the cochlea and might therefore increase conductive hearing loss. Methods: Perichondrium was applied to the round window membrane in nine fresh-frozen, nonpathologic temporal bones. In four temporal bones cartilage was applied subsequently. A... περισσότερα »
Editorial Board
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: December 2015 Source:Anthropocene, Volume 12 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PW4ga6 via IFTTT
A Deficient Diagnosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A previously healthy boy, 2 1/2… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RFUHBq via IFTTT
Free vitamin D does not vary through the follicular phase of the menstrual cycle
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract The importance of vitamin D (25OHD) in general health and reproductive success has been a focus in the setting of the 25OHD deficiency epidemic. However, there are challenges to understanding 25OHD’s effects. The free and bioavailable levels are affected by 25OHD binding protein (DBP) and it is not known how estradiol fluctuations during the […]
A Deficient Diagnosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A previously healthy boy, 2 1/2… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RFUHBq via IFTTT
Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Early diagnosis is a key objective in clinical medicine, and early detection of pathological short stature has tangible benefits for growth prognosis and the well-being of the child. Despite late diagnosis being common in growth disorders, programmes of height screening in primary care are not universal in developed countries and may be random or non-existent. […]
Transforming growth factor-β, interleukin-17, and IL-23 gene expression profiles associated with human peri-i mplantitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Objectives The mRNA expression profiles of IL-23/Th17 and the Treg-associated cytokine TGF-β in peri-implantitis are currently under research. This study characterized the IL-17, IL-23, and TGF-β gene expression levels in healthy and diseased peri-implant tissues and correlated these data with radiographic bone loss. Material and Methods Peri-implant soft tissues from 40 subjects (20 healthy […]
IFC (Journal of Ethnopharmacology)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: 26 May 2016 Source:Journal of Ethnopharmacology, Volume 184 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25MOWIs via IFTTT
Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Toshiaki Suzuki, Keisuke Miyamoto, Naomi Yokoyama, Mayuko Sugi, Akina Kagioka, Yuka Kitao, Takumi Adachi, Masahiro Ohsawa, Hajime Mizukami, Toshiaki Makino Ethnopharmacological relevanceProcessed aconite root (PA, the root of Aconitum carmichaeli, Ranunculaceae) is a crude drug used in traditional Chinese or Japanese kampo medicine to […]
The protective effect of total phenolics from Oenanthe Javanica on acute liver failure induced by D-galactosamine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Guo Ai, Zheng-Ming Huang, Qing-Chuan Liu, Yan-Quan Han, Xi Chen Ethnopharmacology relevanceWater dropwort [Oenanthe javanica (O. javanica)] is an aquatic perennial herb cultivated in East Asian countries. It has been popularly used in traditional Chinese medicine which is beneficial for the treatment of many […]
Testing the absorption of the extracts of Coreopsis tinctoria Nutt. in the intestinal canal in rats using an Ussing chamber
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: 20 June 2016 Source:Journal of Ethnopharmacology, Volume 186 Author(s): Jian Wang, Guzhalinuer Aierken, Xinxia Li, Linlin Li, Xinmin Mao Ethnopharmacological relevanceCoreopsis tinctoria Nutt mainly distributed in Hetian region of Xinjiang at an altitude of 3000m, which is used as Uyghur traditional medicine because of its clearing heat, promoting circulation and removing toxicity and […]
Vogt-Koyanagi-Harada Syndrome: Perspectives for Immunogenetics, Multimodal Imaging and Therapeutic Options
Publication date: Available online 7 April 2016 *Source:*Autoimmunity Reviews Author(s): Sukhum Silpa-archa, Narumol Silpa-archa, Janine M. Preble, C. Stephen Foster Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular and dermatological systems. The primary pathogenesis is T-cell-mediated autoimmune response directed towards melanocyte or melanocyte-associated antigens causing inflammation of the choroidal layer. This phenomenon usually leads to diffuse inflammatory conditions throughout most parts of eye be... περισσότερα »
Zika virus, autoimmunity and microcephaly: other things for consideration
Publication date: Available online 7 April 2016 *Source:*Autoimmunity Reviews Author(s): Viroj Wiwanitkit from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/23klsiS via IFTTT
Reply concerning the article " Zika virus and autoimmunity: from mycrocephaly to Guillain-Barré syndrome, and beyond."
Publication date: Available online 6 April 2016 *Source:*Autoimmunity Reviews Author(s): Darja Kanduc from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1VzHNX6 via IFTTT
Anaphylaxis caused by γ-cyclodextrin in sugammadex
Anaphylaxis caused by γ-cyclodextrin in sugammadex via Allergology International Publication date: Available online 6 April 2016 [image: Responses to the intradermal test of sugammadex (0.1% aq.) (A) and ...] *Source:*Allergology International Author(s): Eri Hotta, Risa Tamagawa-Mineoka, Koji Masuda, Maiko Taura, Yuka Nakagawa, Fuminao Kanehisa, Saki Tashima, Norito Katoh
Skin substitutes
Systematic review and meta-analysis of skin substitutes in the treatment of diabetic foot ulcers: [image: cover.gif?v=1&s=00eca2b4f3bb0b83a2b9cbac] ABSTRACT Skin substitutes are increasingly used in the treatment of various types of acute and chronic wounds. The aim of this study was to perform a systematic review and meta-analysis to evaluate the effectiveness of skin substitutes on ulcer healing and limb salvage in the treatment of diabetic foot ulcers. Randomised clinical trials were searched and assessed following the methodology of The Cochrane Collaboration. We included 17... περισσότερα »
Sixty seconds on . . . the digital NHS
I’d like to understand the plans to digitise the NHS. Is there something I can download and print?Wrong already. The NHS will be paperless by 2020, says Jeremy Hunt, health secretary for England…. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20a51nx via IFTTT
Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes , using a metabolomics approach
Abstract In this study, the metabolic effects of waterborne exposure of medaka (Oryzias latipes) to nominal concentrations of 20 (L group) and 2000 μg/L (H group) 2,4-dichlorophenol (DCP) were examined using a gas chromatography/mass spectroscopy (GC/MS) metabolomics approach. A principal component analysis (PCA) separated the L, H, and control groups along PC1 to explain the… Continue reading Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes , using a metabolomics approach
Patients in the papers
When patients give media interviews, at vulnerable times in their lives, they share something precious of themselves, often out of a desire to help others. Such patients merit the utmost… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Wexmc1 via IFTTT
Organic and inorganic amendment application on mercury-polluted soils: effects on soil chemical and biochemical properties
Abstract On the basis of a previous study performed in our laboratory, the use of organic and inorganic amendments can significantly modify the Hg mobility in soil. We have compared the effectiveness of organic and inorganic amendments such as digestate and fly ash, respectively, reducing the Hg mobility in Chernozem and Luvisol soils differing in… Continue reading Organic and inorganic amendment application on mercury-polluted soils: effects on soil chemical and biochemical properties
James Montgomery Dunlop
bmj;353/apr06_11/i1966/FAF1faJames Montgomery Dunlop (“Jim”) left school at 17 and volunteered for the Royal Air Force, where he was a nurse. After a varied career with the Department of Agriculture… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20a50Qz via IFTTT
Ian Alexander Crowther
After completing his national service in the Royal Army Medical Corps in Nigeria, Ian Alexander Crowther became a partner in a two man practice in Dunblane in 1964.He was a trainer for nine years,… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1WexiJs via IFTTT
John Metcalfe
bmj;353/apr06_9/i1967/FAF1faJohn Metcalfe was born in Pontefract, Yorkshire, to become a passionate advocate of Yorkshire. He joined the Bridge Street Practice in Otley in 1955 and became senior… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20a50jr via IFTTT
IJMS, Vol. 17, Pages 514: Modeling of the Reaction Mechanism of Enzymatic Radical C–C Coupling by Benzyl succinate Synthase
Molecular modeling techniques and density functional theory calculations were performed to study the mechanism of enzymatic radical C–C coupling catalyzed by benzylsuccinate synthase (BSS). BSS has been identified as a glycyl radical enzyme that catalyzes the enantiospecific fumarate addition to toluene initiating its anaerobic metabolism in the denitrifying bacterium Thauera aromatica, and this reaction represents… Continue reading IJMS, Vol. 17, Pages 514: Modeling of the Reaction Mechanism of Enzymatic Radical C–C Coupling by Benzyl succinate Synthase
IJMS, Vol. 17, Pages 512: SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach
Folding free energy is an important biophysical characteristic of proteins that reflects the overall stability of the 3D structure of macromolecules. Changes in the amino acid sequence, naturally occurring or made in vitro, may affect the stability of the corresponding protein and thus could be associated with disease. Several approaches that predict the changes of… Continue reading IJMS, Vol. 17, Pages 512: SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach
IJMS, Vol. 17, Pages 517: Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression
Solid tumor invasion, metastasis and therapeutic drug resistance are the common causes for serious morbidity and cancer recurrence in patients. A number of research studies have searched for malignancy-related biomarkers and drug targets that are closely linked to tumor cell properties. One of the candidates is matrix hyaluronan (HA), which is known as one of… Continue reading IJMS, Vol. 17, Pages 517: Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression
The Transverse Lumbar Perforator Flap
: An Anatomic and Clinical Study via British Association of Plastic Surgeons Publication date: Available online 7 April 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Bhagwat S. Mathur, Shaun S. Tan, F.A. Bhat, Warren Matthew Rozen BackgroundLumbosacral defects are complex reconstructive problems requiring tension free vascularised soft tissue reconstruction in patients who often have co-morbidities. In an area prone to recurrent tissue breakdown, both free and islanded flaps risk complete failure. Cadaveric studies have demonstrated the consistency of l...περισσότερα »
Beard Reconstruction
- a Surgical Algorithm via British Association of Plastic Surgeons Publication date: Available online 6 April 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): M. Ninkovic, P.I. Heidekrueger, D. Ehrl, F. von Spiegel, P.N. Broer BackgroundFacial defects with loss of hair-bearing regions can be caused by trauma, infection, tumor excision, or burn injury. The presented analysis evaluates a series of different surgical approaches with a focus on male beard reconstruction, emphasizing the role of tissue expansion of regional and free flaps.MethodsLoco-regional...περισσότερα »
Incidence and Type of Errors in Microsurgical Technique in Surgical Trainees
Incidence and Type of Errors in Microsurgical Technique in Surgical Trainees: J reconstr Microsurg DOI: 10.1055/s-0036-1581077 Background The purpose of our study was first to identify microsurgical errors and their incidence. Identifying these common errors and the theoretical approach to prevent or repair them may provide benefit to trainees in the laboratory setting and, ultimately, in the clinical setting. Methods Using a rat femoral artery anastomoses model for resident microsurgical training, direct staff observation with real-time feedback and error identification was emp... περισσότερα »
Pincer Flap for Reconstruction of Nasal Tip Defects.Crab-pincers style facial artery flap
Pincer Flap for Reconstruction of Nasal Tip Defects.: Introduction: Reconstruction of the nasal tip defects is challenging because of variable contours of the region and the unique texture, thickness, color, and limited amount of available skin. There are several well-known local flaps for this purpose. Unfortunately, most of these flaps are suitable for small sized defects up to 2 cm in diameter. In this study, the authors are presenting a new flap for reconstruction of nasal tip and supratip defects larger than 2 cm in diameter. Methods: Pincer flap was used for reconstruction of ... περισσότερα »
Maxillary Sinus Floor Elevation Using Platelet-Rich Plasma Combined With Either Biphasic Calcium Phosphate or Deproteinized Bovine Bone.
Maxillary Sinus Floor Elevation Using Platelet-Rich Plasma Combined With Either Biphasic Calcium Phosphate or Deproteinized Bovine Bone.: Purpose: Maxillary sinus floor elevation procedure has the objective of augmenting available bone in atrophic posterior maxilla to allow dental implants placement. The main aim of this prospective study was to evaluate clinically and histomorphometrically the performance of biphasic calcium phosphate (BCP) used in conjunction with platelet-rich plasma (PRP) compared with demineralized bovine bone matrix (DBBM) and PRP in sinus floor elevation surg...περισσότερα »
Functional status and quality of life in elderly intensive care unit survivors
Journal of the American Geriatrics Society from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1S4CyiU via IFTTT
Identifying elder abuse in the emergency department: toward a multidisciplinary team-based approach
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20a7X3j via IFTTT
Management of a mass casualty event caused by electrocution using doctor helicopters
Air Medical Journal from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1S4CuQg via IFTTT
Biomechanical comparison of locked versus non-locked symphyseal plating of unstable pelvic ring injuries
European Journal of Trauma and Emergency Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20a7TRm via IFTTT
New electronic stethoscope and computer program diagnose lung conditions
Hiroshima University News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1S4CuzH via IFTTT
Improvement in Craniosynostosis Surgery
Pediatric National Surgical Quality Improvement Program: Useful for Quality Improvement in Craniosynostosis Surgery?.: The American College of Surgeons and the American Pediatric Surgical Association collaborate to provide pediatric hospitals with multispeciality surgical outcomes data through the Pediatric National Surgical Quality Improvement Program (NSQIP Peds). The authors used this national multicenter database to describe 30-day outcomes from craniosynostosis surgery and identify associations with perioperative events and blood transfusion. Data from NSQIP Peds were used to d...περισσότερα »
Therapeutic Effects of Sildenafil on Experimental Mandibular Fractures.
Therapeutic Effects of Sildenafil on Experimental Mandibular Fractures.: Objectives: No previous studies have examined the effect of sildenafil on fracture healing. This study was designed to investigate the effect of sildenafil on the fracture healing process. Methods: Thirty-six female Sprague-Dawley rats (3-month-old) were used in this study. Animals were randomly divided into 2 groups based on treatment duration (1 week versus 4 weeks) and each group was then divided further into 2 subgroups, control (C) and study (S) groups. Group C (C1, C2) was treated daily with saline soluti... περισσότερα »
Delayed Facial Palsy After Microvascular Decompression for Hemifacial Spasm.
Delayed Facial Palsy After Microvascular Decompression for Hemifacial Spasm.: The purpose of this article is to study the etiology, treatment, and prognosis of delayed facial palsy (DFP) after microvascular decompression (MVD) for the hemifacial spasm. Between January 2012 and January 2014, 562 patients who underwent MVD for hemifacial spasm at our institution were retrospectively studied. Among 562 patients, 34 patients developed DFP after MVD with an incidence of 6%. The duration of palsy was 15 to 136 days (average 51.2 days). There was statistical relevance between preoperative ...περισσότερα »
Surgical Treatment Outcomes of Head and Neck Lymphatic Malformations in Patients With a Variety of Ages and Unusual Sites.
Surgical Treatment Outcomes of Head and Neck Lymphatic Malformations in Patients With a Variety of Ages and Unusual Sites.: Objective: The objective of this study was to review the clinical characteristics and surgical treatment outcomes of head and neck lymphatic malformations and to define the risk factors for recurrence. Methods: A retrospective chart review was performed at Chonnam National University Hwasun Hospital from January 2010 to February 2015. Results: The unusual sites for a head and neck lymphatic malformation were tonsil, buccal space, nasopharynx, and the vallecula.... περισσότερα »
Rat Iliolumbar Vein as a Training Model for Microsurgical End-to-Side Anastomosis.
Rat Iliolumbar Vein as a Training Model for Microsurgical End-to-Side Anastomosis.: Although a multitude of microsurgical training models have been reported, few experimental animal models are available for end-to-side anastomosis. In this study, the authors developed an end-to-side anastomosis rat training model that utilizes the iliolumbar vein and investigated its characteristics. Ten Wistar male rats were used as microvascular end-to-side anastomosis models. Diameters of the posterior vena cava and the root of the iliolumbar vein were measured on both sides. The mean diameter of... περισσότερα »
Bifidobacteria inhibit the growth of Porphyromonas gingivalis but not of Streptococcus mutans
in an in vitro biofilm model: There is growing interest in the use of probiotic bifidobacteria for enhancement of the therapy, and in the prevention, of oral microbial diseases. However, the results of clinical studies assessing the effects of bifidobacteria on the oral microbiota are controversial, and the mechanisms of actions of probiotics in the oral cavity remain largely unknown. In addition, very little is known about the role of commensal bifidobacteria in oral health. Our aim was to study the integration of the probiotic *Bifidobacterium animalis* subsp. *lactis* Bb12 and ... περισσότερα »
Inflammatory pseudotumour of the maxilla
Inflammatory pseudotumour of the maxilla: AbstractInflammatory pseudotumour (IP), also known as inflammatory myofibroblastic tumour (IMT), is a rare lesion of the maxillofacial skeleton and a diagnosis by exclusion. We describe three cases which affected the maxilla, two women and one man of ages 67, 56 and 70 years at presentation. All showed the typical, rather non-specific histopathological features. IgG4-positive plasma cells varied greatly in prominence, and none of the three lesions expressed ALK-1. Both women responded to steroids and radiotherapy, though one also required a...περισσότερα »
Resected tumours of the sublingual gland
: 15 years’ experience: Sublingual gland tumours are rare, and we have evaluated the clinical features and prognosis of patients treated at a tertiary medical centre in eastern Taiwan. We retrospectively reviewed the cases of nine patients with sublingual gland tumours that were resected from December 1993 to November 2008, four of whom were men and five women. The median (range) age at diagnosis was 52 (39-63) years. Seven had malignant tumours, of which adenoid cystic carcinoma was the most common. All patients with malignant tumours had neck dissections, and four had cervical lym...περισσότερα »
The fat–fascia paddle only with a composite fibula flap
: marked reduction in donor site morbidity: Fibula free flaps are used widely in head and neck reconstruction, primarily for their versatility and contribution to aesthetic and functional outcomes. The literature suggests that early complications such as wound dehiscence and skin graft loss can occur in up to a third of patients. The healing of these donor sites can be prolonged, and in certain cases may require an operative intervention. A method to overcome this problem is described herein. In raising the skin paddle, a standard lateral approach to the fibula harvest is used.
Engineering Human TMJ Discs
with Protein-Releasing 3D-Printed Scaffolds: The temporomandibular joint (TMJ) disc is a heterogeneous fibrocartilaginous tissue positioned between the mandibular condyle and glenoid fossa of the temporal bone, with important roles in TMJ functions. Tissue engineering TMJ discs has emerged as an alternative approach to overcoming limitations of current treatments for TMJ disorders. However, the anisotropic collagen orientation and inhomogeneous fibrocartilaginous matrix distribution present challenges in the tissue engineering of functional TMJ discs. Here, we developed 3-dimensio...περισσότερα »
Host-Microbiome Cross-talk in Oral Mucositis
Host-Microbiome Cross-talk in Oral Mucositis: Oral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen–related treatment, resulting in the formation of ulcers, which are susceptible to increased colonization of microorganisms. Novel discoveries in OM have focused on understanding the host-microbial interactions, because current pathways have shown that major virulence factors from microorganisms have the potential to contribute to the development of OM and may even prolong the existence of already established ulcerations, affecting tissue...περισσότερα »
Mechanical Stress-Mediated Cartilage Thinning
Ca2+-Dependent Endoplasmic Reticulum Stress Regulates Mechanical Stress-Mediated Cartilage Thinning: Our previous study identified that endoplasmic reticulum stress (ERS) plays a critical role in chondrocyte apoptosis and mandibular cartilage thinning in response to compressive mechanical force, although the underlying mechanisms remain elusive. Because the endoplasmic reticulum (ER) is a primary site of intracellular Ca2+ storage, we hypothesized that Ca2+-dependent ERS might be involved in mechanical stress–mediated mandibular cartilage thinning. In this study, we used in vitro a... περισσότερα »
Effect of Round Window Reinforcement on Hearing
A Temporal Bone Study With Clinical Implications for Surgical Reinforcement of the Round Window.: Hypothesis: Round window reinforcement leads to conductive hearing loss. Background: The round window is stiffened surgically as therapy for various conditions, including perilymphatic fistula and superior semicircular canal dehiscence. Round window reinforcement reduces symptoms in these patients. However, it also reduces fluid displacement in the cochlea and might therefore increase conductive hearing loss. Methods: Perichondrium was applied to the round window membrane in nine fres...περισσότερα »
Diffusion-weighted Magnetic Resonance Imaging in Necrotizing Otitis Externa.
Diffusion-weighted Magnetic Resonance Imaging as a Novel Imaging Modality in Assessing Treatment Response in Necrotizing Otitis Externa.: Objective: To report our initial experience of diffusion-weighted magnetic resonance imaging (DW-MRI) as a novel imaging tool for assessing and monitoring treatment response in necrotizing otitis externa (NOE). Patients: Seven adults with a diagnosis of NOE on both clinical and computed tomography (CT) criteria who were subsequently monitored with at least two echoplanar DW-MRI investigations were included in this retrospective longitudinal observ... περισσότερα »
Craniocervical Pneumatization
: Estimation of Prevalence and Imaging of Treatment Response.: Objective: Estimate the prevalence of craniocervical pneumatization (CCP) and describe successful treatment of this condition with clinical and radiologic correlation. Patients: Individuals with documented CCP on computed tomography (CT). Intervention(s): CT scans of the head, temporal bone, face, neck, and cervical spine. Cessation of habitual Valsalva maneuver (VM) and insertion of pressure-equalization (PE) tubes. Main Outcome Measure: The prevalence of CCP on CT examinations performed during two decades in a large a...περισσότερα »
Click Stimulus Electrocochleography Versus MRI With Intratympanic Contrast in Meniere's Disease: A Systematic Review.
A Systematic Review.: Objective: To evaluate the diagnostic value of electrocochleography compared with magnetic resonance imaging (MRI) with intratympanic gadolinium administration to diagnose endolymphatic hydrops in patients with Meniere's disease. Data Sources: An electronic search was performed in the PubMed, EMBASE, and Cochrane databases on September 15, 2015. A systematic search was conducted. Articles were included if written in English, Dutch, German, or French language. Study Selection: Original studies reporting on the diagnostic value of electrocochleography compared ... περισσότερα »
Reflectance Measures from Infant Ears with Normal Hearing and Transient Conductive Hearing Loss.
Objective: The objective is to develop methods to utilize newborn reflectance measures for the identification of middle-ear transient conditions (e.g., middle-ear fluid) during the newborn period and ultimately during the first few months of life. Transient middle-ear conditions are a suspected source of failure to pass a newborn hearing screening. The ability to identify a conductive loss during the screening procedure could enable the referred ear to be either (1) cleared of a middle-ear condition and recommended for more extensive hearing assessment as soon as possible, or (2) su... περισσότερα »
Patterns of Long-term Hearing Loss in Hearing Preservation Cochlear Implant Surgery.
Objective: To describe patterns of hearing loss in patients with low-frequency residual hearing after cochlear implantation. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Cochlear implant candidates with immediate postoperative residual low-frequency hearing. Interventions: Hybrid or traditional cochlear implant. Main Outcome Measure: Audiograms to measure postoperative hearing. Results: Of the 166 patients reviewed, 17 ears met the inclusion criteria. The age ranged from 3 years 2 months to 86 years. Etiology was unknown (n = 6), presbycusis... περισσότερα »
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