Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 27 Ιανουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,January 27th,2016


Cardiac Index During Major Noncardiac Surgery : Photoplethysmography Versus Esophageal Doppler

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
A Comparison of Photoplethysmography Versus Esophageal Doppler for the Assessment of Cardiac Index During Major Noncardiac Surgery: [image: image] BACKGROUND: In this prospective observational study, we compared changes in cardiac index (CI) during fluid challenge using photoplethysmography (PPG; Nexfin™) (CIPPG) versus esophageal Doppler (ED) (CIED) in major noncardiac surgery patients. METHODS: Measurements were obtained when the attending anesthesiologist decided to perform a fluid challenge. Correlations with linear regression, Bland-Altman analysis, and analysis of covariance w... περισσότερα »

Wireless Connectivity from Patient Monitors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
A Technical Evaluation of Wireless Connectivity from Patient Monitors to an Anesthesia Information Management System During Intensive Care Unit Surgery: [image: image]Surgical procedures performed at the bedside in the neonatal intensive care unit (NICU) at The Children’s Hospital of Philadelphia were documented using paper anesthesia records in contrast to the operating rooms, where an anesthesia information management system (AIMS) was used for all cases. This was largely because of logistical problems related to connecting cables between the bedside monitors and our portable AIMS ...περισσότερα »

Bupivacaine-Induced Myotoxicity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Modification of Bupivacaine-Induced Myotoxicity with Dantrolene and Caffeine In Vitro: [image: image]BACKGROUND: Local anesthetics, especially bupivacaine, have myotoxic effects in clinically used concentrations and context. Detailed mechanisms of these effects are unknown, but an increase in intracellular calcium levels is suspected to be the most important trigger. Dantrolene and caffeine modify cellular calcium release from the sarcoplasmic reticulum. The aim of our study was to investigate the effect of dantrolene and caffeine on bupivacaine-induced myotoxicity in vitro. METHODS:...περισσότερα »

Nitrite Reduces Ischemia-Induced Ventricular Arrhythmias

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Nitrite Reduces Ischemia-Induced Ventricular Arrhythmias by Attenuating Connexin 43 Dephosphorylation in Rats: [image: image] BACKGROUND: Ventricular arrhythmias induced by ischemic heart disease are the main cause of sudden cardiac death. Ischemia can cause life-threatening arrhythmias by modulating connexin 43 (Cx43), a principal cardiac gap junction channel protein. The present study investigates whether nitrite can attenuate ischemia-induced ventricular arrhythmias and dephosphorylation of Cx43 in a rat model. METHODS: Rats were medicated with normal saline (control, n = 10), ni...περισσότερα »

Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus: A Meta-Analysis of Randomized Trials: [image: image]BACKGROUND: Pruritus is a common side effect of intrathecal fentanyl or sufentanil that decreases patient satisfaction and may delay hospital discharge. There are conflicting reports about the efficacy of prophylactic ondansetron in reducing the incidence of pruritus. This meta-analysis aimed to assess the effect of prophylactic ondansetron on the incidence of intrathecal fentanyl- or sufentanil-mediated pruritus and the need for r... περισσότερα »

Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Use of Tranexamic Acid Is Associated with Reduced Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures: A Retrospective Cohort Study: [image: image] BACKGROUND: Compared with other procedures, complex skull base neurosurgery has the potential for increased intraoperative blood loss yet coagulation near eloquent cranial structures should be minimized. The safety and efficacy of the antifibrinolytic, tranexamic acid in elective neurosurgical procedures is not known. Our primary objective was to determine the relationship between the use of tranexamic acid and tran... περισσότερα »

Speed of Airway Reflex Recovery : The Effect of Anesthetic Choice (Sevoflurane Versus Desflurane) and Neuromuscular Management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
The Effect of Anesthetic Choice (Sevoflurane Versus Desflurane) and Neuromuscular Management on Speed of Airway Reflex Recovery: [image: image]BACKGROUND: Nonintubated patients receiving sevoflurane have slower protective airway reflex recovery after anesthesia compared with patients receiving desflurane. We asked whether this difference would remain significant among intubated patients receiving rocuronium or whether the impact of variable neuromuscular recovery would predominate and thus minimize differences between anesthetics. METHODS: After obtaining written informed consent, pa...περισσότερα »

The Impact of Monitoring on the Initiation of Cardiopulmonary Resuscitation in Children: Friend or Foe?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
The Impact of Monitoring on the Initiation of Cardiopulmonary Resuscitation in Children: Friend or Foe?: Abstract BACKGROUND: The immediate initiation and high quality of basic life support (BLS) are pivotal to improving patient outcome after cardiac arrest. Although cardiorespiratory monitoring could shorten the time to recognize the onset of cardiac arrest, little is known about how monitoring and the misinterpretation of monitor readings could impair the initiation of BLS. In this study, we assessed the speed of initiation and quality of BLS in simulated monitored and nonmoni... περισσότερα »

Dexmedetomidine-Associated Hemodynamic Instability

Risk Factors for Dexmedetomidine-Associated Hemodynamic Instability in Noncardiac Intensive Care Unit Patients: BACKGROUND: The reported incidence of hypotension and bradycardia in patients receiving dexmedetomidine for sedation commonly exceeds 50%. In this study, we describe the incidence of, patient- and treatment-specific risk factors for, and clinical significance of dexmedetomidine-associated hemodynamic instability. METHODS: This retrospective cohort study […]

Policies for Case Scheduling Within 1 Day of Surgery by Markov Chain Models

Comparing Policies for Case Scheduling Within 1 Day of Surgery by Markov Chain Models: BACKGROUND: In previous studies, hospitals’ operating room (OR) schedules were influenced markedly by decisions made within a few days of surgery. At an academic hospital, 46% of ORs had their last case scheduled or changed within 1 working day of surgery, […]

Management of the polyallergic patient with allergy immunotherapy: a practice-based approach

Management of the polyallergic patient with allergy immunotherapy: a practice-based approach: The great majority (60–80 %) of patients consulting specialist physicians for allergic respiratory disease are polysensitized and thus may be potentially clinically polyallergic. However, management approaches… Pascal DemolyEmail author, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn Allergy, Asthma & Clinical Immunology201612:2 DOI: […]

i-Scan detection of minimal change esophagitis in dyspeptic patients with or without Gastroesophageal Reflux disease

BMC Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1Tnglek Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqIA6 via IFTTT

Efficacy and safety of daclatasvir and asunaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C

Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1UpMSPh Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KafKKT via IFTTT

Use of the over-the-scope clip to treat massive bleeding at the transitional zone of the anal canal: a case series

Gastrointestinal Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1TngnmA Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqIA2 via IFTTT

Predictors of proton pump inhibitor failure in non-erosive reflux disease: A study with impedance-pH monitoring and high-resolution manometry

Neurogastroenterology & Motility from #Medicine via ola Kala on Inoreader http://ift.tt/1Tngn64 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KafKKR via IFTTT

Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis

Digestive and Liver Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1UpMQXI Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqIA0 via IFTTT

Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate-stage HCC: Phase II, randomized, double-blind space trial

Journal of Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1TngmPD Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqIzY via IFTTT

Racial disparities in treatment and survival of patients with hepatocellular carcinoma in the United States

Hepatobiliary Surgery and Nutrition from #Medicine via ola Kala on Inoreader http://ift.tt/1UpMSim Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqKIg via IFTTT

Intermittent Hypoxia Causes Inflammation and Injury to Human Adult Cardiac Myocytes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Intermittent Hypoxia Causes Inflammation and Injury to Human Adult Cardiac Myocytes: [image: image] BACKGROUND: Intermittent hypoxia may occur in a number of clinical scenarios, including interruption of myocardial blood flow or breathing disorders such as obstructive sleep apnea. Although intermittent hypoxia has been linked to cardiovascular and cerebrovascular disease, the effect of intermittent hypoxia on the human heart is not fully understood. Therefore, in the present study, we compared the cellular responses of cultured human adult cardiac myocytes (HACMs) exposed to interm... περισσότερα »

A Morphologic Obstructive Sleep Apnea Prediction Score: The DES-OSA Score

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Development and Validation of a Morphologic Obstructive Sleep Apnea Prediction Score: The DES-OSA Score: [image: image] BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score that would detect OSA based on the patient’s morphologic characteristics only. METHODS: Patients (n = 149) scheduled for an overnight polysomnography were included. Their morphologic metrics were compared, and combinations of them were tested for their ability to ... περισσότερα »

Intraoperative 3D Transesophageal Echocardiography

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Intraoperative Three-Dimensional Transesophageal Echocardiography Facilitates Aortic Plaque Evaluation

Awake Craniotomy: A New Airway Approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Awake Craniotomy: A New Airway Approach: [image: image] Awake craniotomies have been performed regularly at the University of Pennsylvania since 2004. Varying approaches to airway management are described for this procedure, including intubation with an endotracheal tube and use of a laryngeal mask airway, simple facemask, or nasal cannula. In this case series, we describe the successful use (i.e., no need for endotracheal intubation related to inadequate gas exchange) of bilateral nasopharyngeal airways in 90 patients undergoing awake craniotomies. The use of nasopharyngeal airway... περισσότερα »

Halogenated volatile anesthetics provide significant anti-inflammatory actions and protect the endothelium against ischemia-reperfusion injury, despite their inhibiting effects on endothelium-dependent vasorelaxation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Unraveling Interactions Between Anesthetics and the Endothelium: Update and Novel Insights: [image: image]The vascular endothelium is one of the largest organs in the body and consists of a single layer of highly specialized cells with site-specific morphology and functions. Endothelial cells play a vital role in the regulation of vascular tone in arterial, venous, microvascular, and lymphatic vascular beds. The endothelium also coordinates angiogenesis and controls cell adhesion, fluid homeostasis, and both innate and adaptive immunity. Fundamental research has shown that general a... περισσότερα »

Baked egg and milk do not accelerate tolerance to egg and milk

Debates in allergy medicine: baked egg and milk do not accelerate tolerance to egg and milk: There is emerging evidence that children with egg and cow’s milk allergy who can tolerate these allergens cooked in baked goods are more likely to develop tolerance. As a result a hypothesis has arisen that exposure to egg and […]

Probiotics in functional bowel disorders

Best Practice & Research Clinical Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1UpMQqD Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OYqIjF via IFTTT

Hemodynamic effect of the left gastric artery on esophageal varices in patients with cirrhosis

Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1TngjDq Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KafICM via IFTTT

Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease

Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1Tngj6n Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KafICI via IFTTT

Zervixkarzinom: Unnötige Therapien vermeiden

S3-Leitlinie Stadienorientierte Strategie ist das Schlagwort der S3-Leitline zum Zervixkarzinom. So sollen die Patientinnen nicht nur bestmöglich behandelt, sondern auch vor unnötigen Therapien geschützt werden. Für den Arzt steigt damit die Verantwortung im Rahmen der Primärdiagnose. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UpNDrB via IFTTT

Antibiotics, Vol. 5, Pages 9: Acknowledgement to Reviewers of Antibiotics in 2015

The editors of Antibiotics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. […] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZScFRP via IFTTT

Viruses, Vol. 8, Pages 31: Molecular Studies of HTLV-1 Replication: An Update

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy/tropical spastic paraparesis (HAM/TSP). The […]

Depression may pass from mothers to daughters

Depression is more likely to be inherited from mothers to daughters than from mothers to sons or fathers to either gender, says MRI-based research into brain structures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RN6bEi via IFTTT

Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression

Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor […]

Forests, Vol. 7, Pages 29: Impacts of Forest to Urban Land Conversion and ENSO Phase on Water Quality of a Public Water Supply Reservoir

We used coupled watershed and reservoir models to evaluate the impacts of deforestation and l Niño Southern Oscillation (ENSO) phase on drinking water quality. Source water total organic carbon (TOC) is especially important due to the potential for production of carcinogenic disinfection byproducts (DBPs). The Environmental Fluid Dynamics Code (EFDC) reservoir model is used to […]

Sleep apnea after posterior cerebral artery aneurysm rupture and elevated intracranial pressure: a chiari-like syndrome

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 15 δευτερόλεπτα
Publication date: Available online 26 January 2016 *Source:*Sleep Medicine Author(s): E. Morrone, C. Pistarini, B. Cazzulani, M. Rossi, A. Prpa, Francesco Fanfulla Graphical abstract [image: image] from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1nndGoB via IFTTT

Intermittent hypoxemia and sleep fragmentation: associations with daytime alertness in obese sleep apnea patients living at moderate altitude

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 15 δευτερόλεπτα
[image: S13899457.gif] Publication date: Available online 26 January 2016 *Source:*Sleep Medicine Author(s): Matilde Valencia-Flores, Babak Mokhlesi, Victoria Santiago-Ayala, Montserrat Reséndiz-García, Alejandra Castaño-Meneses, María Sonia Meza-Vargas, Alejandro Mendoza, Arturo Orea-Tejeda, Guillermo García-Ramos, Carlos Aguilar-Salinas, Donald L. Bliwise BackgroundAlthough obstructive sleep apnea (OSA) has long been associated with daytime sleepiness, far less is known about its association with the ability to remain awake. The aim of this study was to examine the relative import...περισσότερα »

Risk-Adjusted Pediatric Anesthesia-Related Cardiac Arrest

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Anesthesiologist- and System-Related Risk Factors for Risk-Adjusted Pediatric Anesthesia-Related Cardiac Arrest: [image: image]BACKGROUND: Pediatric anesthesia-related cardiac arrest (ARCA) is an uncommon but potentially preventable adverse event. Infants and children with more severe underlying disease are at highest risk. We aimed to identify system- and anesthesiologist-related risk factors for ARCA. METHODS: We analyzed a prospectively collected patient cohort data set of anesthetics administered from 2000 to 2011 to children at a large tertiary pediatric hospital. Pre-procedure ...περισσότερα »

Lack of Analgesic Effect Induced by Ropivacaine Wound Infiltration in Thyroid Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Lack of Analgesic Effect Induced by Ropivacaine Wound Infiltration in Thyroid Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial: [image: image] BACKGROUND: Surgical site infiltration with local anesthetic reduces analgesic requests in various types of surgeries. Because thyroid surgery may induce severe postoperative pain, we tested the hypothesis that ropivacaine surgical site infiltration would significantly decrease postoperative administration of morphine in patients undergoing thyroid surgery. METHODS: We performed a double-blind, placebo-controlled superiority tria...περισσότερα »

Dexmedetomidine-Associated Hemodynamic Instability

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Risk Factors for Dexmedetomidine-Associated Hemodynamic Instability in Noncardiac Intensive Care Unit Patients: [image: image] BACKGROUND: The reported incidence of hypotension and bradycardia in patients receiving dexmedetomidine for sedation commonly exceeds 50%. In this study, we describe the incidence of, patient- and treatment-specific risk factors for, and clinical significance of dexmedetomidine-associated hemodynamic instability. METHODS: This retrospective cohort study was conducted in critically ill adults receiving dexmedetomidine for sedation at Mayo Clinic Hospital in ...περισσότερα »

Policies for Case Scheduling Within 1 Day of Surgery by Markov Chain Models

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Comparing Policies for Case Scheduling Within 1 Day of Surgery by Markov Chain Models: [image: image]BACKGROUND: In previous studies, hospitals’ operating room (OR) schedules were influenced markedly by decisions made within a few days of surgery. At an academic hospital, 46% of ORs had their last case scheduled or changed within 1 working day of surgery, and a private hospital had 64%. Many of these changes were for patients who were admitted before surgery (i.e., inpatient cases). In this study, we investigate the impact on OR productivity of how cases are scheduled within 1 worki...περισσότερα »

Management of the polyallergic patient with allergy immunotherapy: a practice-based approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Management of the polyallergic patient with allergy immunotherapy: a practice-based approach: The great majority (60–80 %) of patients consulting specialist physicians for allergic respiratory disease are polysensitized and thus may be potentially clinically polyallergic. However, management approaches... Pascal DemolyEmail author, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn Allergy, Asthma & Clinical Immunology201612:2 DOI: 10.1186/s13223-015-0109-6© Demoly et al. 2015 Received: 23 October 2015Accepted: 22 December 2015Published: 11 January 2016 Ba...περισσότερα »

Cloning and Expression of Ama r 1, as a Novel Allergen of Amaranthus retroflexus Pollen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Cloning and Expression of Ama r 1, as a Novel Allergen of Amaranthus retroflexus Pollen: Sensitisation to Amaranthus retroflexus pollen is very common in tropical and subtropical countries. In this study we aimed to produce a recombinant allergenic Ole e 1-like protein from the pollen of this weed. To predict cross-reactivity of this allergen (Ama r 1) with other members of the Ole e 1-like protein family, the nucleotide sequence homology of the Ama r 1 was investigated. The expression of Ama r 1 in Escherichia coli was performed by using a pET-21b(+) vector. The IgE-binding potenti...περισσότερα »

Myeloid-derived suppressor cells (MDSC) were defined as lineage negative (CD3–, CD19–, CD56–), HLA-DR–/low, CD11b+ and CD33+.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
A subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanoma: Seventy-eight melanoma patients and 10 healthy individuals were examined. Follow-up examinations of all melanoma patients were performed regularly every three months. Myeloid-derived suppressor cells (MDSC) were defined as lineage negative (CD3–, CD19–, CD56–), HLA-DR–/low, CD11b+ and CD33+. Classification of granulocytic (GrMDSC) and monocytic (MoMDSC) subsets was based on the CD15 and CD14 expression, respectively. Unlike the MoMD... περισσότερα »

Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways: Thymic stromal lymphopoietin (TSLP) and IL-33 are epithelium-derived proallergic cytokines that contribute to allergic diseases. Although the involvement of TSLP in allergic rhinitis (AR) is suggested, the exact role of TSLP in AR is poorly understood. Furthermore, the relative contribution of TSLP and IL-33 in nasal allergic responses has not been described. In this study, we examined the roles of TSLP and IL-33 in AR by analyzing acute and chronic AR models. Acute AR mice were i...περισσότερα »

Granulocytic myeloid-derived suppressor cells in peripheral blood of patients with cutaneous melanoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Granulocytic myeloid-derived suppressor cells in peripheral blood of patients with cutaneous melanoma 1. Cindy Franklin and 2. Bastian Schilling -Author Affiliations 1. Department of Dermatology, University Hospital, West German Cancer Center, University Duisburg-Essen and German Cancer Consortium (DKTK), Essen, Germany 1. *Correspondence to*: B. Schilling; E-mail: bastian.schilling@uk-essen.de To the Editor-in-Chief, The article published in this issue (p. XX) by Stanojevic *et al.* (1) describes a myeloid-derived suppressor cell (MDSC) subset that is ... περισσότερα »

Visualization of the inferior alveolar nerve

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
A novel method for visualization of the inferior alveolar nerve for clinical and educational purposes via ScienceDirect Publication: Journal of Oral Biosciences Publication date: Available online January 2016 *Source:*Journal of Oral Biosciences Author(s): Joe Iwanaga, Tsuyoshi Saga, Yoko Tabira, Koichi Watanabe, Koh-ichi Yamaki The detailed nervous system in the mandibular bone cannot be observed on computed tomography. Dental professionals need to understand the running route of the inferior alveolar nerve and can do so by using gross anatomical dissection. However, the nervous syste... περισσότερα »

The cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes via ScienceDirect Publication: Journal of Oral Biosciences *Source:*Journal of Oral Biosciences Author(s): Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross... περισσότερα »

Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland and its relation to sex, taking into account age and allergic sensitisation.We assessed incidence of self-report of doctor-diagnosed asthma between 1991/1992 and 2010/2011 […]

RFX transcription factors are essential for hearing in mice

Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development have been described, little is known about the postnatal regulators of maturating HCs. Here […]

Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi

Six extracts from the roots and the aerial parts of Waltheria indica L. (Malvaceae) were screened for their in vitro antitrypanosomal activity towards Trypanosoma brucei brucei STIB 427 strain, T. brucei rhodesiense STIB 900 and Trypanosoma cruzi Tulahuen C4. The dichloromethane extract from the roots showed the highest activity against T. cruzi (IC50=0.74μg/mL) as well […]

A ratio chain-type exponential estimator for finite population mean using double sampling

In this article, we have proposed a ratio chain-type exponential estimator for finite population mean of the study variable under double sampling scheme using auxiliary variables. The large sample properties of the suggested strategy are derived up to first order, of approximation, and its competence conditions are carried out under which the suggested estimator is […]

Association between iron status and thyroid function in Nepalese children

Background: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. Methods: A cross-sectional study was conducted among 227 school children aged 6–12 years living in hilly regions of eastern Nepal. Urine […]

Seasonal prediction of lightning activity in North Western Venezuela: Large-scale versus local drivers

Publication date: 15 May–1 June 2016 Source:Atmospheric Research, Volumes 172–173 Author(s): Á.G. Muñoz, J. Díaz-Lobatón, X. Chourio, M.J. Stock The Lake Maracaibo Basin in North Western Venezuela has the highest annual lightning rate of any place in the world (~200flkm−2yr−1), whose electrical discharges occasionally impact human and animal lives (e.g., cattle) and frequently affect economic […]

Association between iron status and thyroid function in Nepalese children

Background: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. Methods: A cross-sectional study was conducted among 227 school children aged 6–12 years living in hilly regions of eastern Nepal. Urine […]

Seasonal prediction of lightning activity in North Western Venezuela: Large-scale versus local drivers

Publication date: 15 May–1 June 2016 Source:Atmospheric Research, Volumes 172–173 Author(s): Á.G. Muñoz, J. Díaz-Lobatón, X. Chourio, M.J. Stock The Lake Maracaibo Basin in North Western Venezuela has the highest annual lightning rate of any place in the world (~200flkm−2yr−1), whose electrical discharges occasionally impact human and animal lives (e.g., cattle) and frequently affect economic […]

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS

Publication date: Available online 26 January 2016 Source:Experimental Cell Research Author(s): Jun Wu, Xiangyou Li, Geli Zhu, Yanxia Zhang, Min He, Jian Zhang It has been suggested that continuous exposure of peritoneal mesothelial cells (PMCs) to high glucose-containing peritoneal dialysis (PD) solutions may result in peritoneal inflammatory injury and impairment of local peritoneal host defence. […]

Alzheimer’s-related brain changes occur 2 decades before symptom onset

Researchers from Karolinska Institutet identified inflammatory brain changes among people with Alzheimer’s-related gene mutations 20 years before estimated symptom onset. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20s6fL7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

A comparison between robotic-assisted laparoscopic distal pancreatectomy versus laparoscopic distal pancreatectomy

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 24 δευτερόλεπτα
Abstract Background This study aims to compare the early perioperative outcomes of robotic-assisted laparoscopic distal pancreatectomy (RDP) versus laparoscopic distal pancreatectomy (LDP). Methods The clinicopathologic features of 45 consecutive patients who underwent minimally-invasive distal pancreatectomy from 2006 to 2015 were retrospectively reviewed. Results Thirty-nine patients who met our study criteria were included. Eight patients underwent RDP and 31 had LDP. There were 10 (25.6%) open conversions. Six (15.4%) patients had major (> grade 2) morbidities and there wa...περισσότερα »

Robotic management of gastric stromal tumors (GIST): a single Middle Eastern center experience

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 24 δευτερόλεπτα
Abstract Background Surgical resection is the gold standard treatment for gastrointestinal stromal tumors (GISTs). This paper describes the authors' experience in the management of posterior gastric wall GISTs through the robotic surgical approach. Methods A case-series analysis for surgically resected GISTs was conducted between 2009 and 2010. All patients were followed up until mid-2015. Results Robotic resection was performed in four cases. There was no evidence of bleeding or leak in all cases. The median hospital length of stay was 8 (5–8) days. No post-operative morbidity...περισσότερα »

Green propolis on oral pathogens

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Effect of Brazilian green propolis on oral pathogens and human periodontal fibroblasts via ScienceDirect Publication: Journal of Oral Biosciences Publication date: Available online 27 November 2015 *Source:*Journal of Oral Biosciences Author(s): Hirotake Oda, Taneaki Nakagawa, Kosuke Maruyama, Yuzuru Dono, Hiroaki Katsuragi, Soh Sato ObjectivesPlaque biofilm is the main etiological factor in dental caries and periodontitis. This study aimed to evaluate the effects of Brazilian green propolis (BGP), which has antibacterial and anti-inflammatory properties, on the growth of oral pathogen... περισσότερα »

Subgingival microbiota

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Profiling subgingival microbiota of plaque biofilms in the elderly via ScienceDirect Publication: Journal of Oral Biosciences *Source:*Journal of Oral Biosciences Author(s): Yuki Abiko, Takuichi Sato, Reiko Sakashita, Junko Tomida, Yoshiaki Kawamura, Nobuhiro Takahashi ObjectivesThe frequency of periodontitis among elderly is increasing in Japan. This study aimed to quantify the periodontitis-associated bacteria in subgingival plaques from elderly patients with periodontitis and from periodontally healthy subjects.MethodsSubgingival plaque samples were collected from independent subje...περισσότερα »

Streptococcus mutans biofilm formation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
is dependent on extracellular DNA in primary low pH conditions via ScienceDirect Publication: Journal of Oral Biosciences *Source:*Journal of Oral Biosciences Author(s): Taketo Kawarai, Naoki Narisawa, Yusuke Suzuki, Ryo Nagasawa, Hidenobu Senpuku ObjectiveStreptococcus mutans is an etiological agent of human dental caries and produces glucosyltransferase (GTF), encoded by genes gtfB and gtfC, an enzyme that synthesizes insoluble glucan from sucrose to form sticky biofilms. However, GTF functions are limited by pH. To observe the effects of low pH in primary culture conditions, we pe... περισσότερα »

The Chronic Oral Mucosal Diseases Questionnaire

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Validity and reliability of the Chronic Oral Mucosal Diseases Questionnaire in a UK population: Objective The objective of this study was to investigate the validity and reliability of a the Chronic Oral Mucosal Diseases Questionnaire in a UK population Methods Two hundred patients with chronic oral mucosal disease (oral lichen planus, recurrent aphthous stomatitis, mucous membrane pemphigoid, pemphigus vulgaris) were enrolled in this study from the Oral Medicine Department of University College London Hospitals Trust (UCLHT) Eastman Dental Hospital. Individuals were interviewed usi... περισσότερα »

Precision of fibula positioning guide in mandibular reconstruction with a fibula graft

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Precision of fibula positioning guide in mandibular reconstruction with a fibula graft: Background: This study examined the usefulness of the fibula positioning guide for boosting the accuracy of mandible reconstructions. Methods: Thirty mandibular rapid prototype (RP) models were allocated to experimental (N = 15) and control (N = 15) groups. For reference, we prepared a reconstructed mandibular RP model with a three-dimensional printer, based on surgical simulation. In the experimental group, a fibula positioning guide template and fibula cutting guide, based on simulation, were us...περισσότερα »

New guidelines for HER2 pathological diagnostics in gastric cancer

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1nncyRN via IFTTT

Current status of the histopathological assessment, diagnosis, and reporting of colorectal neuroendocrine tumors: A Web survey from the Japanese Society for Cancer of Colon and Rectum

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Although new classifications for neuroendocrine tumors were established by the World Health Organization, the current procedures and terms used in pathology laboratories are not known. A Web-based questionnaire was distributed to 491 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum, and 150 participated. The questionnaires included questions regarding routine pathological reporting, staining, and assessment of neuroendocrine tumors. Next, the time taken to assess Ki-67 index and mitotic count according to recommendation was evaluated to determi... περισσότερα »

Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor invasion around the peritoneal surface. In addition, pathological characteristic features of marked tumor budding, fibrosis, and macrophage infiltration in the tumor area with ELI was elucidated. Thi... περισσότερα »

Forests, Vol. 7, Pages 29: Impacts of Forest to Urban Land Conversion and ENSO Phase on Water Quality of a Public Water Supply Reservoir

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
We used coupled watershed and reservoir models to evaluate the impacts of deforestation and l Niño Southern Oscillation (ENSO) phase on drinking water quality. Source water total organic carbon (TOC) is especially important due to the potential for production of carcinogenic disinfection byproducts (DBPs). The Environmental Fluid Dynamics Code (EFDC) reservoir model is used to evaluate the difference between daily pre- and post- urbanization nutrients and TOC concentration. Post-disturbance (future) reservoir total nitrogen (TN), total phosphorus (TP), TOC and chlorophyll-a concen... περισσότερα »

Sports, Vol. 4, Pages 6: “You’re Not Born with Talent” Talented Girls’ and Boys’ Perceptions of Their Talents as Football Players

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Generally in sports, there is a strong assumption of a connection between skill level in young age and adulthood. Studies have mainly focused on the coaches' understanding and role in identifying and developing talent. In this article we turn our attention towards the athletes' perspectives, interviewing talented young football players (five boys and five girls) about their perceptions of their own talent and development. The objective of the article is to investigate how boys and girls perceive their talent and to discuss how various perceptions influence coaching practice in tal... περισσότερα »

IJMS, Vol. 17, Pages 166: Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and i... περισσότερα »

Energies, Vol. 9, Pages 83: The Chaotic-Based Control of Three-Port Isolated Bidirectional DC/DC Converters for Electric and Hybrid Vehicles

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Three-port isolated (TPI) bidirectional DC/DC converters have three energy ports and offer advantages of large voltage gain, galvanic isolation ability and high power density. For this reason this kind of converters are suitable to connect different energy sources and loads in electric and hybrid vehicles. The purpose of this paper is to propose chaotic modulation and the related control scheme for TPI bidirectional DC/DC converters, in such a way that the switching harmonic peaks can be suppressed in spectrum and the conducted electromagnetic interference (EMI) is reduced. Two ch... περισσότερα »

Forests, Vol. 7, Pages 27: Effects of Forest Gaps on Litter Lignin and Cellulose Dynamics Vary Seasonally in an Alpine Forest

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
To understand how forest gaps and the associated canopy control litter lignin and cellulose dynamics by redistributing the winter snow coverage and hydrothermal conditions in the growing season, a field litterbag trial was conducted in the alpine Minjiang fir (Abies faxoniana Rehder and E.H. Wilson) forest in a transitional area located in the upper reaches of the Yangtze River and the eastern Tibetan Plateau. Over the first year of litter decomposition, the litter exhibited absolute cellulose loss and absolute lignin accumulation except for the red birch litter. The changes in li... περισσότερα »

IJMS, Vol. 17, Pages 163: The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD Mice

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Icariin, a pharmacologically active component isolated from the Chinese herb Epimedium, has been shown to improve spatial learning and memory abilities in Alzheimer's disease (AD) rats through inhibition of Aβ production and tau protein hyperphosphorylation. However, the potential mechanism of icariin-induced protective effects against mitochondrial dysfunctions in AD still remains unclear. In the present study, we investigated the effect of icariin on the modulation of mitochondrial transport and distribution in primary hippocampal cultures from triple-transgenic (3× Tg) AD mice....περισσότερα »

Energies, Vol. 9, Pages 81: The Health Costs of Revised Coal Mining Limits in Northern Bohemia

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Brown coal has been the major source of energy for more than 150 years for the Czech economy, but its role in the coming decades is nowadays the source of heated debate. Many of the recurring discussions address the coal reserves that were set aside in 1991 in order to halt the massive destruction of the landscape and the unprecedented deterioration of the human environment in Northern Bohemia. We study the proposed variants of the revised mining limits using the impact-pathway approach in order to quantify and monetize the health effects of airborne emissions from coal mining and... περισσότερα »

Remote Sensing, Vol. 8, Pages 98: Study of the Effect of Temporal Sampling Frequency on DSCOVR Observations Using the GEOS-5 Nature Run Results (Part I): Earth’s Radiation Budget

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Satellites always sample the Earth-atmosphere system in a finite temporal resolution. This study investigates the effect of sampling frequency on the satellite-derived Earth radiation budget, with the Deep Space Climate Observatory (DSCOVR) as an example. The output from NASA's Goddard Earth Observing System Version 5 (GEOS-5) Nature Run is used as the truth. The Nature Run is a high spatial and temporal resolution atmospheric simulation spanning a two-year period. The effect of temporal resolution on potential DSCOVR observations is assessed by sampling the full Nature Run data wi...περισσότερα »

Viruses, Vol. 8, Pages 31: Molecular Studies of HTLV-1 Replication: An Update

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 31 δευτερόλεπτα
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy/tropical spastic paraparesis (HAM/TSP). The ability to treat the aggressive ATL subtypes remains inadequate. HTLV-1 replicates by (1) an infectious cycle involving virus budding and infection of new permissive target cells a...περισσότερα »

Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression

Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor […]

Gata2 is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice

Endocrinology, Early Release. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1SarYqb via IFTTT

All hormone-producing cell types of the pituitary intermediate and anterior lobes derive from Prop1 expressing progenitors

Endocrinology, Early Release. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QrDmtP via IFTTT

Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice is Independent of Ghrelin.

Endocrinology, Early Release. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1SarY9z via IFTTT

Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model

Endocrinology, Early Release. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QrDolt via IFTTT

Free IL-15 is more abundant than IL-15 complexed with soluble IL-15 receptor-alpha in murine serum: Implications for the mechanism of IL-15 secretion

Endocrinology, Early Release. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Sas0hB via IFTTT

A comparison between robotic-assisted laparoscopic distal pancreatectomy versus laparoscopic distal pancreatectomy

Abstract Background This study aims to compare the early perioperative outcomes of robotic-assisted laparoscopic distal pancreatectomy (RDP) versus laparoscopic distal pancreatectomy (LDP). Methods The clinicopathologic features of 45 consecutive patients who underwent minimally-invasive distal pancreatectomy from 2006 to 2015 were retrospectively reviewed. Results Thirty-nine patients who met our study criteria were included. Eight patients underwent […]

Robotic management of gastric stromal tumors (GIST): a single Middle Eastern center experience

Abstract Background Surgical resection is the gold standard treatment for gastrointestinal stromal tumors (GISTs). This paper describes the authors’ experience in the management of posterior gastric wall GISTs through the robotic surgical approach. Methods A case-series analysis for surgically resected GISTs was conducted between 2009 and 2010. All patients were followed up until mid-2015. Results […]

Effects of selective serotonin and norepinephrine reuptake inhibitors on depressive- and impulsive-like behaviors and on monoamine transmission in experimental temporal lobe epilepsy

Summary Objective Examine therapeutic potential of a selective serotonin reuptake inhibitor (SSRI) and a norepinephrine reuptake inhibitor (NERI) in an animal model of comorbidity between epilepsy, depression-like, and impulsive-like impairments. Methods Epilepsy was induced in male Wistar rats by LiCl and pilocarpine. An SSRI fluoxetine (FLX), and an NERI reboxetine (RBX) were administered either alone […]

Remote Sensing, Vol. 8, Pages 99: Hyperspectral Imagery Classification Using Sparse Representations of Convolutional Neural Network Features

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
In recent years, deep learning has been widely studied for remote sensing image analysis. In this paper, we propose a method for remotely-sensed image classification by using sparse representation of deep learning features. Specifically, we use convolutional neural networks (CNN) to extract deep features from high levels of the image data. Deep features provide high level spatial information created by hierarchical structures. Although the deep features may have high dimensionality, they lie in class-dependent sub-spaces or sub-manifolds. We investigate the characteristics of deep... περισσότερα »

Fibers, Vol. 4, Pages 4: Experiment-Based Sensitivity Analysis of Scaled Carbon-Fiber-Reinforced Elastomeric Isolators in Bonded Applications

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Fiber-reinforced elastomeric isolators (FREIs) are a new type of elastomeric base isolation systems. Producing FREIs in the form of long laminated pads and cutting them to the required size significantly reduces the time and cost of the manufacturing process. Due to the lack of adequate information on the performance of FREIs in bonded applications, the goal of this study is to assess the performance sensitivity of 1/4-scale carbon-FREIs based on the experimental tests. The scaled carbon-FREIs are manufactured using a fast cold-vulcanization process. The effect of several factors ... περισσότερα »

Sports, Vol. 4, Pages 7: Effects of Short-Term Dynamic Constant External Resistance Training and Subsequent Detraining on Strength of the Trained and Untrained Limbs: A Randomized Trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Short-term resistance training has been shown to increase isokinetic muscle strength and performance after only two to nine days of training. The purpose of this study was to examine the effects of three days of unilateral dynamic constant external resistance (DCER) training and detraining on the strength of the trained and untrained legs. Nineteen men were randomly assigned to a DCER training group or a non-training control group. Subjects visited the laboratory eight times, the first visit was a familiarization session, the second visit was a pre-training assessment, the subsequ... περισσότερα »

Mechanistic investigation of the on-surface enzymatic digestion (oSED) protein adsorption detection method using targeted mass spectrometry

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02091C, Paper Torgny Undin, Andreas Pettersson Dahlin, Katarina Hornaeus, Jonas Bergquist, Sara Lind This paper describes an effort to study some of the mechanistic aspects of the earlier established on-surface enzymatic digestion (oSED) method. In a multitude of application areas, it has become... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1nxw92p Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece...περισσότερα »

Improving delivery of secondary prophylaxis for rheumatic heart disease in remote Indigenous communities: study protocol for a stepped-wedge randomised trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Background: Rheumatic heart disease (RHD), caused by acute rheumatic fever (ARF), is a major health problem in Australian Aboriginal communities. Progress in controlling RHD requires improvements in the delivery of secondary prophylaxis, which comprises regular, long-term injections of penicillin for people with ARF/RHD.Methods/DesignThis trial aims to improve uptake of secondary prophylaxis among Aboriginal people with ARF/RHD to reduce progression or worsening of RHD. This is a stepped-wedge, randomised trial in consenting communities in Australia's Northern Territory. Pairs of ... περισσότερα »

Forests, Vol. 7, Pages 29: Impacts of Forest to Urban Land Conversion and ENSO Phase on Water Quality of a Public Water Supply Reservoir

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
We used coupled watershed and reservoir models to evaluate the impacts of deforestation and l Niño Southern Oscillation (ENSO) phase on drinking water quality. Source water total organic carbon (TOC) is especially important due to the potential for production of carcinogenic disinfection byproducts (DBPs). The Environmental Fluid Dynamics Code (EFDC) reservoir model is used to evaluate the difference between daily pre- and post- urbanization nutrients and TOC concentration. Post-disturbance (future) reservoir total nitrogen (TN), total phosphorus (TP), TOC and chlorophyll-a concen... περισσότερα »

Sports, Vol. 4, Pages 6: “You’re Not Born with Talent” Talented Girls’ and Boys’ Perceptions of Their Talents as Football Players

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Generally in sports, there is a strong assumption of a connection between skill level in young age and adulthood. Studies have mainly focused on the coaches' understanding and role in identifying and developing talent. In this article we turn our attention towards the athletes' perspectives, interviewing talented young football players (five boys and five girls) about their perceptions of their own talent and development. The objective of the article is to investigate how boys and girls perceive their talent and to discuss how various perceptions influence coaching practice in tal... περισσότερα »

IJMS, Vol. 17, Pages 166: Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and i... περισσότερα »

Energies, Vol. 9, Pages 83: The Chaotic-Based Control of Three-Port Isolated Bidirectional DC/DC Converters for Electric and Hybrid Vehicles

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Three-port isolated (TPI) bidirectional DC/DC converters have three energy ports and offer advantages of large voltage gain, galvanic isolation ability and high power density. For this reason this kind of converters are suitable to connect different energy sources and loads in electric and hybrid vehicles. The purpose of this paper is to propose chaotic modulation and the related control scheme for TPI bidirectional DC/DC converters, in such a way that the switching harmonic peaks can be suppressed in spectrum and the conducted electromagnetic interference (EMI) is reduced. Two ch... περισσότερα »

Forests, Vol. 7, Pages 27: Effects of Forest Gaps on Litter Lignin and Cellulose Dynamics Vary Seasonally in an Alpine Forest

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
To understand how forest gaps and the associated canopy control litter lignin and cellulose dynamics by redistributing the winter snow coverage and hydrothermal conditions in the growing season, a field litterbag trial was conducted in the alpine Minjiang fir (Abies faxoniana Rehder and E.H. Wilson) forest in a transitional area located in the upper reaches of the Yangtze River and the eastern Tibetan Plateau. Over the first year of litter decomposition, the litter exhibited absolute cellulose loss and absolute lignin accumulation except for the red birch litter. The changes in li... περισσότερα »

IJMS, Vol. 17, Pages 163: The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD Mice

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Icariin, a pharmacologically active component isolated from the Chinese herb Epimedium, has been shown to improve spatial learning and memory abilities in Alzheimer's disease (AD) rats through inhibition of Aβ production and tau protein hyperphosphorylation. However, the potential mechanism of icariin-induced protective effects against mitochondrial dysfunctions in AD still remains unclear. In the present study, we investigated the effect of icariin on the modulation of mitochondrial transport and distribution in primary hippocampal cultures from triple-transgenic (3× Tg) AD mice....περισσότερα »

Energies, Vol. 9, Pages 81: The Health Costs of Revised Coal Mining Limits in Northern Bohemia

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Brown coal has been the major source of energy for more than 150 years for the Czech economy, but its role in the coming decades is nowadays the source of heated debate. Many of the recurring discussions address the coal reserves that were set aside in 1991 in order to halt the massive destruction of the landscape and the unprecedented deterioration of the human environment in Northern Bohemia. We study the proposed variants of the revised mining limits using the impact-pathway approach in order to quantify and monetize the health effects of airborne emissions from coal mining and... περισσότερα »

Remote Sensing, Vol. 8, Pages 98: Study of the Effect of Temporal Sampling Frequency on DSCOVR Observations Using the GEOS-5 Nature Run Results (Part I): Earth’s Radiation Budget

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Satellites always sample the Earth-atmosphere system in a finite temporal resolution. This study investigates the effect of sampling frequency on the satellite-derived Earth radiation budget, with the Deep Space Climate Observatory (DSCOVR) as an example. The output from NASA's Goddard Earth Observing System Version 5 (GEOS-5) Nature Run is used as the truth. The Nature Run is a high spatial and temporal resolution atmospheric simulation spanning a two-year period. The effect of temporal resolution on potential DSCOVR observations is assessed by sampling the full Nature Run data wi...περισσότερα »

Viruses, Vol. 8, Pages 31: Molecular Studies of HTLV-1 Replication: An Update

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy/tropical spastic paraparesis (HAM/TSP). The ability to treat the aggressive ATL subtypes remains inadequate. HTLV-1 replicates by (1) an infectious cycle involving virus budding and infection of new permissive target cells a...περισσότερα »

Remote Sensing, Vol. 8, Pages 99: Hyperspectral Imagery Classification Using Sparse Representations of Convolutional Neural Network Features

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
In recent years, deep learning has been widely studied for remote sensing image analysis. In this paper, we propose a method for remotely-sensed image classification by using sparse representation of deep learning features. Specifically, we use convolutional neural networks (CNN) to extract deep features from high levels of the image data. Deep features provide high level spatial information created by hierarchical structures. Although the deep features may have high dimensionality, they lie in class-dependent sub-spaces or sub-manifolds. We investigate the characteristics of deep... περισσότερα »

Fibers, Vol. 4, Pages 4: Experiment-Based Sensitivity Analysis of Scaled Carbon-Fiber-Reinforced Elastomeric Isolators in Bonded Applications

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Fiber-reinforced elastomeric isolators (FREIs) are a new type of elastomeric base isolation systems. Producing FREIs in the form of long laminated pads and cutting them to the required size significantly reduces the time and cost of the manufacturing process. Due to the lack of adequate information on the performance of FREIs in bonded applications, the goal of this study is to assess the performance sensitivity of 1/4-scale carbon-FREIs based on the experimental tests. The scaled carbon-FREIs are manufactured using a fast cold-vulcanization process. The effect of several factors ... περισσότερα »

Sports, Vol. 4, Pages 7: Effects of Short-Term Dynamic Constant External Resistance Training and Subsequent Detraining on Strength of the Trained and Untrained Limbs: A Randomized Trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
Short-term resistance training has been shown to increase isokinetic muscle strength and performance after only two to nine days of training. The purpose of this study was to examine the effects of three days of unilateral dynamic constant external resistance (DCER) training and detraining on the strength of the trained and untrained legs. Nineteen men were randomly assigned to a DCER training group or a non-training control group. Subjects visited the laboratory eight times, the first visit was a familiarization session, the second visit was a pre-training assessment, the subsequ... περισσότερα »

Mechanistic investigation of the on-surface enzymatic digestion (oSED) protein adsorption detection method using targeted mass spectrometry

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 40 δευτερόλεπτα
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02091C, Paper Torgny Undin, Andreas Pettersson Dahlin, Katarina Hornaeus, Jonas Bergquist, Sara Lind This paper describes an effort to study some of the mechanistic aspects of the earlier established on-surface enzymatic digestion (oSED) method. In a multitude of application areas, it has become... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1nxw92p Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece...περισσότερα »

Gata2 is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1SarYqb via IFTTT

All hormone-producing cell types of the pituitary intermediate and anterior lobes derive from Prop1 expressing progenitors

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1QrDmtP via IFTTT

Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice is Independent of Ghrelin.

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1SarY9z via IFTTT

Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1QrDolt via IFTTT

Free IL-15 is more abundant than IL-15 complexed with soluble IL-15 receptor-alpha in murine serum: Implications for the mechanism of IL-15 secretion

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Sas0hB via IFTTT

Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx and efflux transporters

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 44 δευτερόλεπτα
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1QrDnOB via IFTTT

IJMS, Vol. 17, Pages 161: Genome-Wide Identification, Characterization and Expression Analysis of the Chalcone Synthase Family in Maize

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Members of the chalcone synthase (CHS) family participate in the synthesis of a series of secondary metabolites in plants, fungi and bacteria. The metabolites play important roles in protecting land plants against various environmental stresses during the evolutionary process. Our research was conducted on comprehensive investigation of CHS genes in maize (Zea mays L.), including their phylogenetic relationships, gene structures, chromosomal locations and expression analysis. Fourteen CHS genes (ZmCHS01–14) were identified in the genome of maize, representing one of the largest nu...περισσότερα »

IJMS, Vol. 17, Pages 164: The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cysteine, but it also incorporates their alcoholic and acidic metabolites. In this study we examined the metabolic fate of ortho-quinones derived from the catecholamine metabolites, 3,4-dihydroxyphenylethanol (DOPE), 3,4-dihydroxyphenylethylene glycol (DOPEG), 3,4-dihydr... περισσότερα »

A ratio chain-type exponential estimator for finite population mean using double sampling

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
In this article, we have proposed a ratio chain-type exponential estimator for finite population mean of the study variable under double sampling scheme using auxiliary variables. The large sample properties of the suggested strategy are derived up to first order, of approximation, and its competence conditions are carried out under which the suggested estimator is performed better than the other existing estimators discussed in the literature. An empirical study shows that the suggested strategy is more efficient than the other relevant competing estimators under two phase sampli... περισσότερα »

Lubricants, Vol. 4, Pages 1: Acknowledgement to Reviewers of Lubricants in 2015

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
The editors of Lubricants would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1QrCAx9 via IFTTT

Remote Sensing, Vol. 8, Pages 96: Real-Time Classification of Seagrass Meadows on Flat Bottom with Bathymetric Data Measured by a Narrow Multibeam Sonar System

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Seagrass meadows, one of the most important habitats for many marine species, provide essential ecological services. Thus, society must conserve seagrass beds as part of their sustainable development efforts. Conserving these ecosystems requires information on seagrass distribution and relative abundance, and an efficient, accurate monitoring system. Although narrow multibeam sonar systems (NMBSs) are highly effective in resolving seagrass beds, post-processing methods are required to extract key data. The purpose of this study was to develop a simple method capable of detecting se...περισσότερα »

Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 45 δευτερόλεπτα
Background: Molecular profiling has uncovered genetic subtypes of glioblastoma (GBM), including tumors with IDH1 mutations that confer increase survival and improved response to standard-of-care therapies. By mapping the genetic landscape of brain tumors in routine clinical practice, we enable rapid identification of targetable genetic alterations.Case PresentationA 29-year-old male presented with new onset seizures prompting neuroimaging studies, which revealed an enhancing 5 cm intra-axial lesion involving the right parietal lobe. He underwent a subtotal resection and pathologi...περισσότερα »

Cancers, Vol. 8, Pages 19: Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 45 δευτερόλεπτα
Cancers are heterogeneous tissues comprised of multiple components, including tumor cells and microenvironment cells. The tumor microenvironment has a critical role in tumor progression. The tumor microenvironment is comprised of various cell types, including fibroblasts, macrophages and immune cells, as well as extracellular matrix and various cytokines and growth factors. Fibroblasts are the predominant cell type in the tumor microenvironment. However, neither the derivation of tissue-specific cancer-associated fibroblasts nor markers of tissue-specific cancer-associated fibrobl... περισσότερα »

Primary Choriocarcinoma of the Stomach. A Case Report and Review of the Literature

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 45 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/1nxqtFz via IFTTT

Metastatic Carcinoma to Vertebra Mimicking as Primary Malignant Vascular Tumour; A unusual Case Report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 45 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/1nxqrO4 via IFTTT

JPM, Vol. 6, Pages 7: Acknowledgement to Reviewers of Journal of Personalized Medicine in 2015

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
The editors of Journal of Personalized Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1VqAgrn via IFTTT

Energies, Vol. 9, Pages 77: A Sectoral Micro-Economic Approach to Scenario Selection and Development: The Case of the Greek Power Sector

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
Generating policy-relevant scenarios is instrumental for understanding and developing policy measures. These are especially relevant to the power sector. Practitioners have been working on policy-relevant scenarios for the ex-ante assessment of policy measures in a meaningful way for end-users related to climate change mitigation and adaptation strategies. This paper presents a method for generating such policy relevant scenarios by focusing on the actor-contingent elements of the scenarios, i.e., the developments that are within the control of system actors to change or bring abou... περισσότερα »

Entropy, Vol. 18, Pages 42: Non-Extensive Entropic Distance Based on Diffusion: Restrictions on Parameters in Entropy Formulae

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
Based on a diffusion-like master equation we propose a formula using the Bregman divergence for measuring entropic distance in terms of different non-extensive entropy expressions. We obtain the non-extensivity parameter range for a universal approach to the stationary distribution by simple diffusive dynamics for the Tsallis and the Kaniadakis entropies, for the Hanel–Thurner generalization, and finally for a recently suggested log-log type entropy formula which belongs to diverging variance in the inverse temperature superstatistics. from #Medicine via ola Kala on Inoreader http... περισσότερα »

Improving delivery of secondary prophylaxis for rheumatic heart disease in remote Indigenous communities: study protocol for a stepped-wedge randomised trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 50 δευτερόλεπτα
Background: Rheumatic heart disease (RHD), caused by acute rheumatic fever (ARF), is a major health problem in Australian Aboriginal communities. Progress in controlling RHD requires improvements in the delivery of secondary prophylaxis, which comprises regular, long-term injections of penicillin for people with ARF/RHD.Methods/DesignThis trial aims to improve uptake of secondary prophylaxis among Aboriginal people with ARF/RHD to reduce progression or worsening of RHD. This is a stepped-wedge, randomised trial in consenting communities in Australia's Northern Territory. Pairs of ... περισσότερα »

Robotic management of gastric stromal tumors (GIST): a single Middle Eastern center experience

Abstract Background Surgical resection is the gold standard treatment for gastrointestinal stromal tumors (GISTs). This paper describes the authors’ experience in the management of posterior gastric wall GISTs through the robotic surgical approach. Methods A case-series analysis for surgically resected GISTs was conducted between 2009 and 2010. All patients were followed up until mid-2015. Results […]

Effects of selective serotonin and norepinephrine reuptake inhibitors on depressive- and impulsive-like behaviors and on monoamine transmission in experimental temporal lobe epilepsy

Summary Objective Examine therapeutic potential of a selective serotonin reuptake inhibitor (SSRI) and a norepinephrine reuptake inhibitor (NERI) in an animal model of comorbidity between epilepsy, depression-like, and impulsive-like impairments. Methods Epilepsy was induced in male Wistar rats by LiCl and pilocarpine. An SSRI fluoxetine (FLX), and an NERI reboxetine (RBX) were administered either alone […]

Seizures as presenting and prominent symptom in chorea-acanthocytosis with c.2343del VPS13A gene mutation

Abstract Objective The aim of the study was to characterize the clinical features of nine patients in three families with chorea-acanthocytosis (ChAc) sharing the same rare c.2343del mutation in the VPS13A gene. Methods Genetic test results, clinical description, magnetic resonance imaging (MRI), and electroencephalography (EEG), as well as laboratory results are summarized. Results ChAc is […]

Heart rate variability in untreated newly diagnosed temporal lobe epilepsy: Evidence for ictal sympathetic dysregulation

Summary Objective To compare heart rate variability (HRV) parameters in newly diagnosed and untreated temporal lobe epilepsy (TLE) between the interictal, preictal, ictal, and postictal states. Methods HRV parameters were extracted from single-lead electrocardiography data collected during video–electroencephalography (EEG) recordings from 14 patients with newly diagnosed TLE in a resting, awake, and supine state. HRV […]

IJMS, Vol. 17, Pages 162: A Common Variant of PROK1 (V67I) Acts as a Genetic Modifier in Early Human Pregnancy through Down-Regulation of Gene Expression

PROK1-V67I has been shown to play a role as a modifier gene in the PROK1-PROKR system of human early pregnancy. To explore the related modifier mechanism of PROK1-V67I, we carried out a comparison study at the gene expression level and the cell function alternation of V67I, and its wild-type (WT), in transiently-transfected cells. We, respectively, […]

IJMS, Vol. 17, Pages 161: Genome-Wide Identification, Characterization and Expression Analysis of the Chalcone Synthase Family in Maize

Members of the chalcone synthase (CHS) family participate in the synthesis of a series of secondary metabolites in plants, fungi and bacteria. The metabolites play important roles in protecting land plants against various environmental stresses during the evolutionary process. Our research was conducted on comprehensive investigation of CHS genes in maize (Zea mays L.), including […]

IJMS, Vol. 17, Pages 164: The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites

ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cysteine, but it also incorporates their alcoholic […]

IJERPH, Vol. 13, Pages 164: Patterns of Bacillary Dysentery in China, 2005–2010

Although the incidence of bacillary dysentery in China has been declining progressively, a considerable disease burden still exists. Few studies have analyzed bacillary dysentery across China and knowledge gaps still exist in the aspects of geographic distribution and ecological drivers, seasonality and its association with meteorological factors, urban-rural disparity, prevalence and distribution of Shigella species. […]

IJERPH, Vol. 13, Pages 162: The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men

Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene and gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs and PCa in 574 subjects from northern China. Body mass index (BMI), smoking, and alcohol consumption were determined through self-administered questionnaires […]

India needs home-grown GM food to stop starvation

Indian scientists must develop domestic genetically modified crops rather than rely on unsuitable foreign technology, says Anurag Chaurasia. Nature 529 439 doi: 10.1038/529439a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UpJ6p3 via IFTTT

Non-invasive programmed stimulation to identify high-risk patients with implanted cardioverter defibrillator (the NIPS-ICD study): study protocol for a randomized controlled trial

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Background: The use of an implantable cardioverter defibrillator (ICD) is a widely used and effective therapy, which reduces the risk of cardiac death in many cardiac diseases, both implanted for secondary and primary prevention. However, recurrent arrhythmias and ICD discharges have adverse prognostic significance. Additional parameters that would identify patients who are at increased risk of arrhythmias and appropriate ICD interventions would be of clinical value. Modern ICDs are relatively complex devices with a number of functions, including the possibility to perform noninvas... περισσότερα »

Fine-needle aspiration diagnosis of primary hydatid disease of the thyroid; first reported case in the USA

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Echinococcosis or hydatid disease (HD) is a parasitic disease caused by species of the Echinococcus genus. Since the incidence of HD in the USA is very low and the primary HD of the thyroid is extremely rare even in endemic regions, the occurrence of primary thyroid HD is exceptional in the USA. Thyroid HD is rarely diagnosed by fine-needle aspiration (FNA). Our literature review revealed less than ten cases of primary HD of thyroid diagnosed by FNA worldwide. Hereby, we report the first case of a primary thyroid HD diagnosed by fine-needle aspiration in the USA. Diagn. Cytopatho... περισσότερα »

Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Background: Molecular profiling has uncovered genetic subtypes of glioblastoma (GBM), including tumors with IDH1 mutations that confer increase survival and improved response to standard-of-care therapies. By mapping the genetic landscape of brain tumors in routine clinical practice, we enable rapid identification of targetable genetic alterations.Case PresentationA 29-year-old male presented with new onset seizures prompting neuroimaging studies, which revealed an enhancing 5 cm intra-axial lesion involving the right parietal lobe. He underwent a subtotal resection and pathologi...περισσότερα »

Effects of selective serotonin and norepinephrine reuptake inhibitors on depressive- and impulsive-like behaviors and on monoamine transmission in experimental temporal lobe epilepsy

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
[image: cover.gif?v=1&s=86d3aef2ad3355d25bd62fb1] Summary Objective Examine therapeutic potential of a selective serotonin reuptake inhibitor (SSRI) and a norepinephrine reuptake inhibitor (NERI) in an animal model of comorbidity between epilepsy, depression-like, and impulsive-like impairments. Methods Epilepsy was induced in male Wistar rats by LiCl and pilocarpine. An SSRI fluoxetine (FLX), and an NERI reboxetine (RBX) were administered either alone or as a combination over 1 week. Depressive-like and impulsive-like behaviors were examined using the forced swim test. Fast sc...περισσότερα »

Seizures as presenting and prominent symptom in chorea-acanthocytosis with c.2343del VPS13A gene mutation

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
[image: cover.gif?v=1&s=86d3aef2ad3355d25bd62fb1] Abstract Objective The aim of the study was to characterize the clinical features of nine patients in three families with chorea-acanthocytosis (ChAc) sharing the same rare c.2343del mutation in the *VPS13A* gene. Methods Genetic test results, clinical description, magnetic resonance imaging (MRI), and electroencephalography (EEG), as well as laboratory results are summarized. Results ChAc is a rare genetic disorder characterized by hyperkinetic movements, seizures, cognitive decline, neuropsychiatric symptoms, and acanthocytes...περισσότερα »

Heart rate variability in untreated newly diagnosed temporal lobe epilepsy: Evidence for ictal sympathetic dysregulation

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Summary Objective To compare heart rate variability (HRV) parameters in newly diagnosed and untreated temporal lobe epilepsy (TLE) between the interictal, preictal, ictal, and postictal states. Methods HRV parameters were extracted from single-lead electrocardiography data collected during video–electroencephalography (EEG) recordings from 14 patients with newly diagnosed TLE in a resting, awake, and supine state. HRV parameters in the time and frequency domains included low frequency (LF), high frequency (HF), standard deviation of all consecutive R wave intervals (SDNN), and s... περισσότερα »

Mailing free nicotine patches to smokers reduces smoking rates, study shows

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Mailing free nicotine patches to smokers without offering any behavioural support can reduce smoking rates, researchers have reported in JAMA Internal Medicine.1The study recruited 1000 adults who… [image: recent?d=yIl2AUoC8zA] [image: recent?d=dnMXMwOfBR0] [image: recent?i=ABi85IFNLiw:DLUBGtmbXcM:V_sGLiP] [image: recent?d=qj6IDK7rITs] [image: recent?i=ABi85IFNLiw:DLUBGtmbXcM:gIN9vFw] [image: recent?d=l6gmwiTKsz0] [image: recent?d=7Q72WNTAKBA] [image: recent?i=ABi85IFNLiw:DLUBGtmbXcM:F7zBnMy] [image: recent?i=ABi85IFNLiw:DLUBGtmbXcM:-BTjWOF] [image: 1JE07vq] from #ORL-AlexandrosSf... περισσότερα »

Similar quit rates are found with three smoking cessation options

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The drug varenicline (Champix) was found to be no better than combination nicotine replacement therapy or a standard nicotine patch in helping adults to stop smoking in the long term, a randomised… [image: recent?d=yIl2AUoC8zA] [image: recent?d=dnMXMwOfBR0] [image: recent?i=jc4KSsV3Hfc:bUoi6ttlapo:V_sGLiP] [image: recent?d=qj6IDK7rITs] [image: recent?i=jc4KSsV3Hfc:bUoi6ttlapo:gIN9vFw] [image: recent?d=l6gmwiTKsz0] [image: recent?d=7Q72WNTAKBA] [image: recent?i=jc4KSsV3Hfc:bUoi6ttlapo:F7zBnMy] [image: recent?i=jc4KSsV3Hfc:bUoi6ttlapo:-BTjWOF] [image: 1OOCsqW] from #ORL-AlexandrosSf... περισσότερα »

Retention efficacy and release of radioiodine in fume hoods

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: S0265931X.gif] Publication date: Available online 26 January 2016 *Source:*Journal of Environmental Radioactivity Author(s): K. Schomäcker, T. Fischer, B. Zimmermanns, J. Bregulla, F. Sudbrock, O. Prante, A. Drzezga Procedures to determine the release of hazardous gaseous substances including radioactive iodine are covered by different norms such as the European standard EN 14175 and the German national standard DIN 25466. The detection of sulphur hexafluoride (SF6) is required to comply with the prescribed methodology. The detection limit of this test is 4.5·10−7 mol/m3 in... περισσότερα »

Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The post Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzKSl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tn3oRZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G... περισσότερα »

Current perspectives on China’s national essential medicine system: primary care provider and patient views

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
AbstractBackground The National Essential Medicine System (NEMS) is a new policy launched by the Chinese government in 2009. The effects of its introduction have been widely investigated. However, little research has focused on individual patients’ perspectives. The purpose of this study was to examine current understanding and opinions of China’s NEMS of primary care providers (PCPs) and patients. Methods Providers (*n* = 134) and patients (*n* = 175) were examined based on self-completed questionnaire surveys conducted in 16 primary healthcare centers in Ningxia, northwestern Chi...περισσότερα »

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Publication date: Available online 26 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona M. Russell, Edward K. Mulholland BackgroundA randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conju... περισσότερα »

A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The post A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzMtu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20s1npy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inore... περισσότερα »

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Publication date: Available online 27 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory diseases of the skin. Recently, IL-17–producing T cells have been shown to play a critical role in psoriatic inflammation. Programmed cell death 1 (PD-1) is a coinhibitory receptor expressed on T cells in ... περισσότερα »

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Publication date: Available online 26 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona M. Russell, Edward K. Mulholland BackgroundA randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conju... περισσότερα »

Current perspectives on China’s national essential medicine system: primary care provider and patient views

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
AbstractBackground The National Essential Medicine System (NEMS) is a new policy launched by the Chinese government in 2009. The effects of its introduction have been widely investigated. However, little research has focused on individual patients’ perspectives. The purpose of this study was to examine current understanding and opinions of China’s NEMS of primary care providers (PCPs) and patients. Methods Providers (*n* = 134) and patients (*n* = 175) were examined based on self-completed questionnaire surveys conducted in 16 primary healthcare centers in Ningxia, northwestern Chi...περισσότερα »

Impact of Cooperative Trial and Sociodemographic Variation on Adjuvant Radiation Therapy Usage in Elderly Women (≥70 years) with Stage I, Estrogen Receptor-Positive Breast Cancer: Analysis of the National Cancer Data Base

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: gr1.sml] Using the National Cancer Data Base, we found that since the Cancer and Leukemia Group B 9343 trial was published in 2004, radiation therapy usage has been reduced by only 3%. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PD6amc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OOBElP via IFTTT

Image De-Identification Methods for Clinical Research in the XDS Environment

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Abstract To investigate possible de-identification methodologies within the Cross-Enterprise Document Sharing for imaging (XDS-I) environment in order to provide strengthened support for image data exchange as part of clinical research projects. De-identification, using anonymization or pseudonymization, is the most common method to perform information removal within DICOM data. However, it is not a standard part of the XDS-I profiles. Different methodologies were observed to define how and where de-identification should take place within an XDS environment used for scientific rese... περισσότερα »

Retention efficacy and release of radioiodine in fume hoods

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: S0265931X.gif] Publication date: Available online 26 January 2016 *Source:*Journal of Environmental Radioactivity Author(s): K. Schomäcker, T. Fischer, B. Zimmermanns, J. Bregulla, F. Sudbrock, O. Prante, A. Drzezga Procedures to determine the release of hazardous gaseous substances including radioactive iodine are covered by different norms such as the European standard EN 14175 and the German national standard DIN 25466. The detection of sulphur hexafluoride (SF6) is required to comply with the prescribed methodology. The detection limit of this test is 4.5·10−7 mol/m3 in... περισσότερα »

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Publication date: Available online 26 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona M. Russell, Edward K. Mulholland BackgroundA randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conju... περισσότερα »

Diagnostic pitfalls in pathological diagnosis of infectious disease: patients with syphilitic lymphadenitis often present with inconspicuous history of infection

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Retrospective study was applied to 16 cases of syphilitic lymphadenitis to elucidate the pathological diagnostic features. The typical morphology of syphilitic lymphadenitis includes: (i) well preserved or partially destroyed lymph node structure; (ii) reactive hyperplasia of lymph follicles with broadened germinal centers in the cortex and medulla of the lymph node; (iii) thickened fibrotic lymph node capsules with infiltration of plasma cells; and (iv) phlebitis and endarteritis in varying degree. Additional morphology includes: (i) focal histiocytes with ingested debris; (ii) n... περισσότερα »

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Publication date: Available online 27 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory diseases of the skin. Recently, IL-17–producing T cells have been shown to play a critical role in psoriatic inflammation. Programmed cell death 1 (PD-1) is a coinhibitory receptor expressed on T cells in ... περισσότερα »

Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des Prostatakarzinoms

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Zusammenfassung Im Jahr 2005 führte die internationale Gesellschaft für Urologische Pathologie (ISUP) eine Konsenskonferenz zur Gleason-Graduierung durch, um dieses Graduierungssystem auf den Stand der zeitgenössischen Praxis zu aktualisieren. Es stellte sich jedoch heraus, dass es weiteren Modifikationsbedarf zur Prostatakarzinomgraduierung gibt. Die Internationale Gesellschaft für Urologische Pathologie führte daher 2014 eine weitere Konsenskonferenz durch, um diese Punkte anzugehen. In der vorliegenden Arbeit werden die wesentlichen Ergebnisse des Chicagoer Graduierungstreffens ... περισσότερα »

Evaluation of the autogenous bone block transfer for dental implant placement: Symphysal or ramus harvesting?

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
AbstractBackground The absence of sufficient bone volume is the most relevant problem in implant dentistry. Grafting from exogenous sources may provide a limited gain but exhibits poor performance in large bone defects. Autogenous bone block transfer (ABBT) from the mandibular symphysis and ramus has been used with varying rates of success. The aim of this study was to compare the efficacy of symphysal and ramus ABBT for the restoration of lost horizontal alveolar bone volume in the anterior maxilla. Implants placed in the augmented areas were also evaluated. Methods The maxillary ... περισσότερα »

Retention efficacy and release of radioiodine in fume hoods

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: S0265931X.gif] Publication date: Available online 26 January 2016 *Source:*Journal of Environmental Radioactivity Author(s): K. Schomäcker, T. Fischer, B. Zimmermanns, J. Bregulla, F. Sudbrock, O. Prante, A. Drzezga Procedures to determine the release of hazardous gaseous substances including radioactive iodine are covered by different norms such as the European standard EN 14175 and the German national standard DIN 25466. The detection of sulphur hexafluoride (SF6) is required to comply with the prescribed methodology. The detection limit of this test is 4.5·10−7 mol/m3 in ... περισσότερα »

A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The post A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzMtu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20s1npy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inor... περισσότερα »

Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The post Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzKSl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tn3oRZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros ... περισσότερα »

A Qualitative Study on Factors that Influence Students’ Food Choices

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The post A Qualitative Study on Factors that Influence Students’ Food Choices appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzN0j via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PiYzav via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lR1ZoV via IFTTT

Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty: Objective To compare the viscoelastic properties of calcium hydroxyapatite (CaHA) to carboxymethylcellulose (CMC) injectables used for injection laryngoplasty and determine if they are affected by heating and shearing. Study Design Experimental. Setting University laboratory. Subjects and Methods Vocal fold injection laryngoplasty with CaHA is oftentimes challenging due to the amount of pressure necessary to push the injectate through a needle. Anecdotal... περισσότερα »

Mini Tracheostomy for Obstructive Sleep Apnea

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Mini Tracheostomy for Obstructive Sleep Apnea: An Evidence Based Proposal: Objective. To search for articles evaluating the use of tracheostomies (either permanent stomas or tracheostomy tubes) in adult obstructive sleep apnea (OSA) patients and to evaluate the potential for the use of mini tracheostomies as treatment for OSA. Study Design. Systematic review. Methods. Nine databases were searched from inception through July 21, 2015. Results. The overall tracheostomy search yielded 516 articles, of which eighteen studies provided polysomnographic data. No study was identified (emp...περισσότερα »

Gentamicin-induced damage in auditory hair cells : Protective effects of the seaweed phlorotannin polyphenolic compound dieckol

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Mun Young Chang, Seon-Hee Byon, Hyeon-Cheol Shin, Song Ee Han, Ju Yeon Kim, Jang Yul Byun, Jong Dae Lee, Moo Kyun Park ObjectivesDrug-induced ototoxicity from compounds such as aminoglycosides and platinum can damage the inner ear resulting in hearing loss, tinnitus or balan...περισσότερα »

Metastatic Carcinoma to Vertebra Mimicking as Primary Malignant Vascular Tumour; A unusual Case Report

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nxqrO4 via IFTTT

Präoperative patientenorientierte Vorausplanung von Notfall- und Intensivbehandlung – Bedarf oder Zumutu ng?

Zusammenfassung Hintergrund Die traditionelle Patientenverfügung kann häufig nicht zufriedenstellend umgesetzt werden. Deswegen kommt der patientenorientierten Therapiezielplanung vor elektiven Interventionen über die eigentliche Operation hinaus ein besonderer Stellenwert zu. Fragestellung Ziele unserer Proof-of-Concept-Studie waren, den Bedarf an patientenorientierter Vorausplanung von Notfall- und Intensivbehandlung zu ermitteln und die Belastung durch derartige Angebote zu beurteilen. Material und Methoden […]

Sepsis durch Raoultella ornithinolytica bei einem immunkompetenten Patienten

Zusammenfassung Bei Raoultella ornithinolytica handelt es sich um ein gramnegatives gekapseltes und aerobes Bakterium, das zur Familie der Enterobacteriaceae gezählt wird und hauptsächlich in Fischen vorkommt. Das auffälligste Merkmal dieses Bakteriums ist die Fähigkeit, Histidin in Histamin umzuwandeln. Der Verzehr von durch Raoultella ornithinolytica verdorbenem Fisch führt zu einem flüchtigen Exanthem, Diarrhöen, einem Erythem, Schwitzen […]

Ultrasound-guided pulsed radiofrequency treatment of the pudendal nerve in chronic pelvic pain

Abstract Chronic pelvic pain is a condition that can be caused by pudendal neuralgia, interstitial cystitis, piriformis syndrome and neuropathy of the ilioinguinal, iliohypogastric and genitofemoral nerves. Based on three case reports this article discusses the clinical effectiveness of pulsed high-frequency radiofrequency (PRF) treatment applied to the pudendal nerve under ultrasound guidance in medicinally treated […]

Schädel-Hirn-Trauma

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Zusammenfassung Unter jungen Erwachsenen gilt das Schädel-Hirn-Trauma (SHT) als die häufigste Ursache von langfristiger Behinderung und Tod, wodurch das SHT eine enorme gesundheitliche und sozialwirtschaftliche Belastung darstellt. Als Folge der Primärläsion entwickelt sich ein perifokales Hirnödem, das aufgrund des begrenzten intrakraniellen Raums einen Anstieg des intrakraniellen Drucks bewirkt. Dies hat eine Reduktion des zerebralen Perfusionsdrucks und somit der zerebralen Durchblutung zur Folge. Eine zerebrale Minderperfusion unterhalb der Ischämieschwelle führt zu weiteren i... περισσότερα »

Organspende nach Herz- und Kreislauftod

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Zusammenfassung In den Niederlanden leben ca. 17 Mio. Einwohner. Die Anzahl an potenziellen postmortalen Organspender war 1999 mit 10 Spenden pro 1 Mio. Einwohner die niedrigste in ganz Europa. Medizinische Fachgesellschaften, öffentliches Gesundheitswesen, Krankenkassen und Gesetzgeber mussten gemeinsam Wege zu einer verbesserten Organallokation, Logistik und Anzahl von Transplantationen finden. Nach andauernder Debatte zu medizinisch-ethischen Themen der Organtransplantation, konnten sich alle Beteiligten schrittweise auf ein gesellschaftlich-medizinisch-juristisches Regelwerk z... περισσότερα »

Schädel-Hirn-Trauma

Zusammenfassung Unter jungen Erwachsenen gilt das Schädel-Hirn-Trauma (SHT) als die häufigste Ursache von langfristiger Behinderung und Tod, wodurch das SHT eine enorme gesundheitliche und sozialwirtschaftliche Belastung darstellt. Als Folge der Primärläsion entwickelt sich ein perifokales Hirnödem, das aufgrund des begrenzten intrakraniellen Raums einen Anstieg des intrakraniellen Drucks bewirkt. Dies hat eine Reduktion des zerebralen Perfusionsdrucks […]

Organspende nach Herz- und Kreislauftod

Zusammenfassung In den Niederlanden leben ca. 17 Mio. Einwohner. Die Anzahl an potenziellen postmortalen Organspender war 1999 mit 10 Spenden pro 1 Mio. Einwohner die niedrigste in ganz Europa. Medizinische Fachgesellschaften, öffentliches Gesundheitswesen, Krankenkassen und Gesetzgeber mussten gemeinsam Wege zu einer verbesserten Organallokation, Logistik und Anzahl von Transplantationen finden. Nach andauernder Debatte zu medizinisch-ethischen Themen […]

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Publication date: Available online 26 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona […]

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Publication date: Available online 27 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory […]

Diagnostic pitfalls in pathological diagnosis of infectious disease: patients with syphilitic lymphadenitis often present with inconspicuous history of infection

Retrospective study was applied to 16 cases of syphilitic lymphadenitis to elucidate the pathological diagnostic features. The typical morphology of syphilitic lymphadenitis includes: (i) well preserved or partially destroyed lymph node structure; (ii) reactive hyperplasia of lymph follicles with broadened germinal centers in the cortex and medulla of the lymph node; (iii) thickened fibrotic lymph […]

Octreotide and enterocutaneous fistula closure in neonates and children

Abstract Enterocutaneous fistula and its conservative management still pose a challenge for the surgeon. The use of octreotide and somatostatin in neonates and children as adjunctive therapy in the conservative management of this condition, leads to major controversy regarding its efficacy. Therefore, we conducted an extensive literature review of published articles regarding the use of […]

UNICT – Il prof. Andrea Bettetini «Académico Honorario» della Real Academia – Liveunict | Magazine sull’Università di Catania

Liveunict | Magazine sull’Università di Catania UNICT – Il prof. Andrea Bettetini «Académico Honorario» della Real Academia Liveunict | Magazine sull’Università di Catania SALUTE – Il sesso orale può condurre ai tumori della testa e del collo Il sesso orale può condurre ai tumori della testa e del collo, oltre a quello già noto della […]

Battle grounds of African «Spiritual Warfare»: pentecostal militancy against «Child Witches», in «Prayer Camps» and in inter-religious encounter

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Tn60z2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Mailing free nicotine patches to smokers reduces smoking rates, study shows

Mailing free nicotine patches to smokers without offering any behavioural support can reduce smoking rates, researchers have reported in JAMA Internal Medicine.1The study recruited 1000 adults who… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOCqiI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Similar quit rates are found with three smoking cessation options

The drug varenicline (Champix) was found to be no better than combination nicotine replacement therapy or a standard nicotine patch in helping adults to stop smoking in the long term, a randomised… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1JE08zp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

CT practice proves vital in mass casualty incidents

Locating a CT scanner as close as possible to the emergency room and implementing… Read more on AuntMinnieEurope.com Related Reading: Paris attacks: Radiology on the front line CT makes world of difference in battlefield imaging from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOCsaq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Publication date: Available online 26 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona […]

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Publication date: Available online 27 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory […]

Diagnostic pitfalls in pathological diagnosis of infectious disease: patients with syphilitic lymphadenitis often present with inconspicuous history of infection

Retrospective study was applied to 16 cases of syphilitic lymphadenitis to elucidate the pathological diagnostic features. The typical morphology of syphilitic lymphadenitis includes: (i) well preserved or partially destroyed lymph node structure; (ii) reactive hyperplasia of lymph follicles with broadened germinal centers in the cortex and medulla of the lymph node; (iii) thickened fibrotic lymph […]

Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des Prostatakarzinoms

Zusammenfassung Im Jahr 2005 führte die internationale Gesellschaft für Urologische Pathologie (ISUP) eine Konsenskonferenz zur Gleason-Graduierung durch, um dieses Graduierungssystem auf den Stand der zeitgenössischen Praxis zu aktualisieren. Es stellte sich jedoch heraus, dass es weiteren Modifikationsbedarf zur Prostatakarzinomgraduierung gibt. Die Internationale Gesellschaft für Urologische Pathologie führte daher 2014 eine weitere Konsenskonferenz durch, um diese […]

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Publication date: Available online 26 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona […]

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Publication date: Available online 27 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory […]

Current perspectives on China’s national essential medicine system: primary care provider and patient views

Abstract Background The National Essential Medicine System (NEMS) is a new policy launched by the Chinese government in 2009. The effects of its introduction have been widely investigated. However, little research has focused on individual patients’ perspectives. The purpose of this study was to examine current understanding and opinions of China’s NEMS of primary care […]

Impact of Cooperative Trial and Sociodemographic Variation on Adjuvant Radiation Therapy Usage in Elderly Women (≥70 years) with Stage I, Estrogen Receptor-Positive Breast Cancer: Analysis of the National Cancer Data Base

Using the National Cancer Data Base, we found that since the Cancer and Leukemia Group B 9343 trial was published in 2004, radiation therapy usage has been reduced by only 3%. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PD6amc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Retention efficacy and release of radioiodine in fume hoods

Publication date: Available online 26 January 2016 Source:Journal of Environmental Radioactivity Author(s): K. Schomäcker, T. Fischer, B. Zimmermanns, J. Bregulla, F. Sudbrock, O. Prante, A. Drzezga Procedures to determine the release of hazardous gaseous substances including radioactive iodine are covered by different norms such as the European standard EN 14175 and the German national standard […]

Image De-Identification Methods for Clinical Research in the XDS Environment

Abstract To investigate possible de-identification methodologies within the Cross-Enterprise Document Sharing for imaging (XDS-I) environment in order to provide strengthened support for image data exchange as part of clinical research projects. De-identification, using anonymization or pseudonymization, is the most common method to perform information removal within DICOM data. However, it is not a standard part […]

Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma

Purpose The chemical exchange saturation transfer (CEST) effect observed in brain tissue in vivo at the frequency offset 3.5 ppm downfield of water was assigned to amide protons of the protein backbone. Obeying a base-catalyzed exchange process such an amide-CEST effect would correlate with intracellular pH and protein concentration, correlations that are highly interesting for cancer […]

Battle grounds of African “Spiritual Warfare”: pentecostal militancy against “Child Witches”, in “Prayer Camps” and in inter-religious encounter

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Tn60z2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Vqx9Qk via IFTTT

Human Umbilical Cord Wharton’s Jelly Stem Cell Conditioned Medium Induces Tumoricidal Effects On Lymphoma Cells Through Hydrogen Peroxide Mediation

ABSTRACT Several groups have reported that human umbilical cord Wharton’s jelly stem cells (hWJSCs) possess unique tumoricidal properties against many cancers. However, the exact mechanisms as to how hWJSCs inhibit tumor growth are not known. Recent evidence suggests that exposure of cancer cells to high hydrogen peroxide (H2O2) levels from H2O2-releasing drugs causes their death. […]

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Publication date: Available online 26 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona […]

Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway during Neuronal Differentiation in vitro

ABSTRACT During differentiation, neurons acquire their typical shape and functional properties. At present, it is unclear, whether this important developmental step involves metabolic changes. Here, we studied the contribution of the mevalonate (MVA) pathway to neuronal differentiation using the mouse neuroblastoma cell line N1E-115 as experimental model. Our results show that during differentiation, the activity […]

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Publication date: Available online 27 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory […]

PPARγ Represses Apolipoprotein A-I Gene but Impedes TNFα-Mediated ApoA-I Downregulation in HepG2 Cells

Abstract Apolipoprotein A-I (ApoA-I) is the main anti-atherogenic component of human high-density lipoproteins (HDL). ApoA-I gene expression is regulated by several nuclear receptors, which are the sensors for metabolic changes during development of cardiovascular diseases. Activation of nuclear receptor PPARγ has been shown to impact lipid metabolism as well as inflammation. Here, we have shown […]

Impact of Cooperative Trial and Sociodemographic Variation on Adjuvant Radiation Therapy Usage in Elderly Women (≥70 years) with Stage I, Estrogen Receptor-Positive Breast Cancer: Analysis of the National Cancer Data Base

Using the National Cancer Data Base, we found that since the Cancer and Leukemia Group B 9343 trial was published in 2004, radiation therapy usage has been reduced by only 3%. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PD6amc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by […]

A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene

Abstract Genetic mutations in MED12, a subunit of Mediator complex are seen in a broad spectrum of human diseases. However, the underlying basis of how these pathogenic mutations elicit protein phenotype changes in terms of 3D structure, stability and protein binding sites remains unknown. Therefore, we aimed to investigate the structural and functional impacts of […]

Current perspectives on China’s national essential medicine system: primary care provider and patient views

Abstract Background The National Essential Medicine System (NEMS) is a new policy launched by the Chinese government in 2009. The effects of its introduction have been widely investigated. However, little research has focused on individual patients’ perspectives. The purpose of this study was to examine current understanding and opinions of China’s NEMS of primary care […]

Sleep apnea after posterior cerebral artery aneurysm rupture and elevated intracranial pressure: a chiari-like syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Sleep apnea after posterior cerebral artery aneurysm rupture and elevated intracranial pressure: a chiari-like syndrome [image: Figure thumbnail sleep2995-ga-5001] Highlights • Sub-arachnoid hemorrhage may determine obstructive sleep apnea, even in patients without risk factors. • In the presence of clinical deterioration, clinicians should consider this complication. • Starting continuous positive airway pressure (CPAP) therapy should be assessed when treatment of elevated intracranial pressure is not indicated. • Sub-arachnoid hemorrhage may determine obstructive sleep apnea, eve... περισσότερα »

Prevention of Strictures Using Carboxymethyl Cellulose Sheets

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Prevention of Esophageal Strictures After Endoscopic Submucosal Dissection: A Promising Therapy Using Carboxymethyl Cellulose Sheets: Abstract BackgroundEsophageal stricture is one of the serious adverse events following endoscopic submucosal dissection (ESD). However, optimum preventive techniques are still lacking. AimsOur primary objective was to evaluate the incidence of post-ESD esophageal stricture with the application of carboxymethyl cellulose (CMC) sheets. Secondary objectives were to determine the number of sessions of endoscopic balloon dilatation (EBD) required to r...περισσότερα »

Food hypersensitivity-induced atopic conditions.Food-specific IgG4 antibody-guided exclusion diet

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
ORIGINAL ARTICLE Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome SAMEER ZAR1 , LYNNE MINCHER2 , MARTIN J. BENSON3 & DEVINDER KUMAR4 1 OGEM Department, St George’s Hospital Medical School, London, UK, 2 Dietetic Department, 3 Department of Gastroenterology, St. Helier Hospital, Carshalton, Surrey, UK, and 4 Department of Gastrointestinal Surgery, St George’s Hospital Medical School, London, UK DOI: 10.1080/00365520510015593 http://www.bio-food.it/intolleranze/Food-specific%20IgG4%20antibody%20guided%20exclusion%20di... περισσότερα »

IgG4-Guided Exclusion Diet : IgG4 titres to 16 foods (milk, eggs, cheese, wheat, rice, potatoes, chicken, beef, pork, lamb, soya bean, fish, shrimps, yeast, tomatoes and peanuts)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Scand J Gastroenterol. 2005 Jul;40(7):800-7. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Zar S1, Mincher L, Benson MJ, Kumar D. Author information 1OGEM Department, St George's Hospital Medical School, London, UK. Abstract OBJECTIVE: Dietary modification improves symptoms in irritable bowel syndrome (IBS). Identification of offending foods by dietary elimination/re-challenge is cumbersome. IgG4 antibodies to common food antigens are elevated in IBS. The aim of this article was to evaluate the effect of exc... περισσότερα »

Autosomal-Recessive Hearing Impairment due to Rare Missense Variants within S1PR2.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Autosomal-Recessive Hearing Impairment due to Rare Missense Variants within S1PR2.: Am J Hum Genet. 2016 Jan 19; Authors: Santos-Cortez RL, Faridi R, Rehman AU, Lee K, Ansar M, Wang X, Morell RJ, Isaacson R, Belyantseva IA, Dai H, Acharya A, Qaiser TA, Muhammad D, Ali RA, Shams S, Hassan MJ, Shahzad S, Raza SI, Bashir ZE, Smith JD, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics, Riazuddin S, Ahmad W, Friedman TB, Leal SM Abstract The sphingosine-1-phosphate receptors (S1PRs) are a well-studied class of transmembrane G protein-coupled sphingolipid ... περισσότερα »

Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis: *Background:* Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disease that manifests as asthma, recurrent sinusitis and peripheral eosinophilia. In this study, we investigated the clinical features of the ear and nasal manifestations of EGPA in comparison with those of granulomatosis with polyangiitis (GPA). *Materials and Methods:* Twenty-one patients diagnosed with EGPA were studied. The frequency of otologic manifestations, the degree of hearing loss and the freq...περισσότερα »

School-Based Speech-Language Pathologists' Knowledge and Perceptions of Autism Spectrum Disorder and Bullying

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
School-Based Speech-Language Pathologists' Knowledge and Perceptions of Autism Spectrum Disorder and Bullying: Purpose The purpose of the current investigation was to examine speech-language pathologists' (SLPs') knowledge and perceptions of bullying, with an emphasis on autism spectrum disorder (ASD). Method A 46-item, web-based survey was used to address the purposes of this investigation. Participants were recruited through e-mail and electronic mailing lists for American Speech-Language-Hearing Association (ASHA) special interest divisions 1 (Language, Learning, and Education)...περισσότερα »

Proton Therapy for Esophageal Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Proton Therapy for Esophageal Cancer: *Condition*: Esophageal Cancer *Intervention*: Radiation: Proton radiation *Sponsor*: Loma Linda University The goal of this phase II study is to investigate the feasibility, toxicity and efficacy of a regimen incorporating a proven systemic regimen, carboplatin /paclitaxel, with conformal proton modality, followed by definitive surgery. In most combined-modality trials to date, chemotherapy regimens have included cisplatin, usually in conjunction with 5-fluorouracil. In designing the regimen, the investigators attempt to improve on the ... περισσότερα »

Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy: *Condition*: Head and Neck Cancer *Interventions*: Procedure: Barium Swallow; Behavioral: Questionnaires; Device: Expiratory Muscle Strength Training (EMST) Device; Device: Digital Manometer; Behavioral: Neurocognitive Exams; Drug: Barium *Sponsors*: M.D. Anderson Cancer Center; IRG ArmsAssigned InterventionsExperimental: Aspirators Group Participants receive modified barium swallow at baseline and after 8 weeks of using the expiratory muscle strength training (EMST) device. Par... περισσότερα »

Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell: *Conditions*: Cancer of the Mouth; Oropharynx Squamous Cell Carcinoma *Interventions*: Behavioral: Symptom Questionnaires; Behavioral: Dysphagia Inventory Questionnaire; Behavioral: Activity Bands *Sponsor*: M.D. Anderson Cancer Center Groups/CohortsAssigned InterventionsIntensity-Modulated Proton Therapy or( IMPT) Group Symptom questionnaires about symptoms of cancer and how they affect life at work and at home, diet, and speech compl... περισσότερα »

Evaluation of the autogenous bone block transfer for dental implant placement: Symphysal or ramus harvesting?

Abstract Background The absence of sufficient bone volume is the most relevant problem in implant dentistry. Grafting from exogenous sources may provide a limited gain but exhibits poor performance in large bone defects. Autogenous bone block transfer (ABBT) from the mandibular symphysis and ramus has been used with varying rates of success. The aim of […]

Retention efficacy and release of radioiodine in fume hoods

Publication date: Available online 26 January 2016 Source:Journal of Environmental Radioactivity Author(s): K. Schomäcker, T. Fischer, B. Zimmermanns, J. Bregulla, F. Sudbrock, O. Prante, A. Drzezga Procedures to determine the release of hazardous gaseous substances including radioactive iodine are covered by different norms such as the European standard EN 14175 and the German national standard […]

A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks

The post A Qualitative Study on Factors that Affect School Lunch Participation: Perspectives of School Food Service Managers and Cooks appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzMtu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis […]

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Publication date: Available online 26 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona […]

Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran

The post Relationship between Prevalence of Overweight and Obesity in Adolescent Girls, and Socio- Economic Status of their Families: A case study in Tehran appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzKSl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros […]

A Qualitative Study on Factors that Influence Students’ Food Choices

The post A Qualitative Study on Factors that Influence Students’ Food Choices appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OOzN0j via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PiYzav via IFTTT from #Med Blogs […]

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Publication date: Available online 27 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Jong Hoon Kim, Young Joon Choi, Byung Ha Lee, Mi-Young Song, Chae Yeon Ban, Jihye Kim, Junsik Park, Song-Ee Kim, Tae-Gyun Kim, Su-Hyung Park, Hyoung-Pyo Kim, Young-Chul Sung, Soo-Chan Kim, Eui-Cheol Shin BackgroundPsoriasis is one of the most common chronic inflammatory […]

Current perspectives on China’s national essential medicine system: primary care provider and patient views

Abstract Background The National Essential Medicine System (NEMS) is a new policy launched by the Chinese government in 2009. The effects of its introduction have been widely investigated. However, little research has focused on individual patients’ perspectives. The purpose of this study was to examine current understanding and opinions of China’s NEMS of primary care […]

Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty

Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty: Objective To compare the viscoelastic properties of calcium hydroxyapatite (CaHA) to carboxymethylcellulose (CMC) injectables used for injection laryngoplasty and determine if they are affected by heating and shearing. Study Design Experimental. Setting University laboratory. Subjects and Methods Vocal fold […]

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου