High Expression of Intestinal Homing Receptor CD103 in Adult T-Cell Leukemia/Lymphoma, Similar to 2 Other CD8+ T-Cell Lymphomas.
High Expression of Intestinal Homing Receptor CD103 in Adult T-Cell Leukemia/Lymphoma, Similar to 2 Other CD8+ T-Cell Lymphomas.: We investigated the expression of the [alpha]E[beta]7 integrin (CD103)-intestinal homing receptor of T-intraepithelial lymphocytes (IELs) in 130 cases of adult T-cell leukemia/lymphoma (ATLL). We detected CD103+ lymphoma cells in 55% (31/56) of mainly gastrointestinal (GI)-involved ATLL cases. Among them, lymphoma cells of 18 cases located in other involved organs had similar CD103 expression patterns. Histologically, we found (a) increased reactive IELs ...περισσότερα »
Intestinal Metaplasia is Present in Most if Not All Patients Who Have Undergone Endoscopic Mucosal Resection for Esophageal Adenocarcinoma.
Intestinal Metaplasia is Present in Most if Not All Patients Who Have Undergone Endoscopic Mucosal Resection for Esophageal Adenocarcinoma.: Barrett esophagus is presently defined in the United States by the presence of intestinal metaplasia in columnar-lined esophagus based on the premise that the risk for adenocarcinoma depends on the presence of intestinal metaplasia. Recently, arguments have been made that nonintestinalized cardiac epithelium is also at risk and should be included in the definition of Barrett esophagus, as it is in England and Japan. One of these arguments is th...περισσότερα »
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.: This review provides a summary of our current understanding of, and the controversies surrounding, the diagnosis, pathogenesis, histopathology, and molecular biology of Barrett's esophagus (BE) and associated neoplasia. BE is defined as columnar metaplasia of the esophagus. There is worldwide controversy regarding the diagnostic criteria of BE, mainly with regard to the requirement to histologically identify goblet cells in biopsies. Patients with BE are at increased risk for adenocarcinoma, which develo... περισσότερα »
TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma
TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma: Background: TRPV6 is over-expressed and promotes the proliferation and invasion in many cancers. The association between the expression of TRPV6 and clinical outcome in esophageal squamous cell carcinoma (ESCC) has not been studied yet. We aim to elucidate the role of TRPV6 in predicting prognosis of patients with ESCC. Methods: In the retrospective study, mRNA level of TRPV6 was examined in patients (N = 174) from Sun Yat-sen University Cancer Center (mRNA cohort) and protein level of ... περισσότερα »
New-onset cutaneous lichen planus following therapy for hepatitis C with ledipasvir-sofosbuvir
New-onset cutaneous lichen planus following therapy for hepatitis C with ledipasvir-sofosbuvir:
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.: BACKGROUND: Methoxycarbonyl etomidate (MOC-etomidate) and cyclopropyl methoxycarbonyl metomidate (CPMM) are rapidly metabolized "soft" etomidate analogs. CPMM's duration of hypnotic effect is context insensitive, whereas MOC-etomidate's is not. In this study, we tested the hypothesis that CPMM's effect is context insensitive because, unlike MOC-etomidate, its metabolite fails to reach physiologically important concentrations in vivo even w... περισσότερα »
Dexmedetomidine Combined with General Anesthesia Provides Similar Intraoperative Stress Response Reduction When Compared with a Combined General and Epidural Anesthetic Technique.
Dexmedetomidine Combined with General Anesthesia Provides Similar Intraoperative Stress Response Reduction When Compared with a Combined General and Epidural Anesthetic Technique.: BACKGROUND: Epidural anesthesia may attenuate the sympathetic hyperactivity and stress response from surgery. In this study, we compared the stress response, hemodynamic variables, and recovery profiles of patients undergoing total IV anesthesia (TIVA) and intraoperative dexmedetomidine with those receiving epidural anesthesia and TIVA. METHODS: Ninety patients undergoing elective open gastrectomy under TI... περισσότερα »
DVD Review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
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Issue Information
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Usxjq4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
NMR Concepts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
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Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Publication date: Available online 28 January 2016 Source:Cellular Signalling Author(s): Shin Yee Hong, Fa-Xing Yu, Yan Luo, Thilo Hagen Oncogenic activation of the PI3K/Akt pathway is known to play an important role in promoting glucose metabolism in cancer cells. However, the molecular mechanism through which the PI3K/Akt signalling pathway promotes glucose utilisation in cancer cells […]
Transforming growth factor type beta (TGF- β) requires reactive oxygen species to induce skeletal muscle atrophy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Publication date: Available online 26 January 2016 Source:Cellular Signalling Author(s): Johanna Abrigo, Juan Carlos Rivera, Felipe Simon, Daniel Cabrera, Claudio Cabello-Verrugio Transforming growth factor beta 1 (TGF- β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration, and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by […]
Analysis of the antibacterial effect of an Edwardsiella tarda LuxS inhibitor
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
LuxS/AI-2 quorum sensing is involved in the virulence of many bacterial pathogens, including the fish pathogen Edwardsiella tarda. In a previous study, we identified a small peptide, 5906, which inhibits E. tarda LuxS activity by binding specifically to LuxS in a manner that probably prevents the formation of functional LuxS homodimer. In the present study, […]
Differential pain response at local and remote muscle sites following aerobic cycling exercise at mild and moderate intensity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Physical exercise has been shown to inhibit experimental pain response in the post-exercise period. Modulation of the pain system may be differentiated between muscle sites engaging in contractile activity. The purpose of this study was to assess the pain response at remote and local muscle sites following aerobic exercise at different work intensities. Participants included […]
Differences in sedentary time and physical activity among mothers and children using a movement-to-music video program in the home environment: a pilot study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Measured objectively, less than a quarter of adults and under half of preschool children in Finland meet the physical activity recommendations. Moreover, higher sedentary time among parents (such as watching television) is associated with higher sedentary time of their children. The study introduces an intervention based on reducing sedentary behavior among mothers and their children. […]
Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
The use of designer drugs has risen severely in recent years. Among others, synthetic cannabinoids and synthetic cathinones have been recognized as the largest categories of new drugs identified in Europe last year [1]. Synthetic cannabinoids are novel psychoactive substances that imitate the effects of cannabis, while synthetic cathinones belong to phenylalkylamine group of drugs […]
PET/MRI with DWI is best option to evaluate lymphomas
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
In the largest study of its kind to date, Austrian researchers have found that… Read more on AuntMinnieEurope.com Related Reading: PET/MRI can be a boon for pediatric cancer patients NEJM: PET for Hodgkin’s lymphoma prevents unnecessary radiotherapy PET/MRI matches PET/CT in NSCLC accuracy DWI adds little to PET/MRI for female pelvic malignancies PET/CT bolsters lymphoma […]
B cells establish, but do not maintain, long-lived murine anti-peanut IgE 1
B cells establish, but do not maintain, long-lived murine anti-peanut IgE 1: Abstract Background Peanut allergy has been reported to be transferred to tolerant recipients through organ and bone marrow transplantation. The roles T and B cells play in establishing, and the roles B cell subsets play in maintaining lifelong anti-peanut IgE levels are unknown. Objectives To determine the cellular requirements for the transfer of murine peanut allergy and to determine the role CD20+ cells play in maintaining long-lived anti-peanut IgE levels. Methods We developed a novel adoptive transfer... περισσότερα »
Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high risk infants: a randomised controlled trial
Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high risk infants: a randomised controlled trial: [image: cover.gif?v=1&s=e49413b3a608982cc9a6b00f] Abstract Background Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes. Objective To evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF-OS) can prevent eczema in high risk infants...περισσότερα »
Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients
Journal of Allergy and Clinical Immunology Available online 28 January 2016 In Press, Corrected Proof — Note to users [image: Cover image] Letter to the Editor Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients - Corinne S. Happel, MDa, - Kelly D. Stone, MD, PhDb, - Alexandra F. Freeman, MDc, - Nirali N. Shah, MDd, - Angela Wang, BSNe, - Jonathan J. Lyons, MDb, - Pamela A. Guerrerio, MD, PhDb, - Dennis D. Hickstein, MDf, - Helen C. Su, MD, PhDa, - a Laboratory o... περισσότερα »
CAD/CAM splint based on soft tissue 3D simulation for treatment of facial asymmetry
CAD/CAM splint based on soft tissue 3D simulation for treatment of facial asymmetry: Abstract BackgroundMost cases of facial asymmetry involve yaw deformity, and determination of the yaw correction level is very difficult. MethodsWe use three-dimensional soft tissue simulation to determine the yaw correction level. This three-dimensional simulation is based on the addition of cephalometric prediction to gradual yaw correction. Optimal yaw correction is determined visually, and an intermediate splint is fabricated with computer-aided design and computer-aided manufacturing. Appl... περισσότερα »
Substance P promotes diabetic wound healing by modulating inflammation and restoring cellular activity of mesenchymal stem cells
Substance P promotes diabetic wound healing by modulating inflammation and restoring cellular activity of mesenchymal stem cells: ABSTRACT Diabetic ulceration is one of the most debilitating complications of diabetes and is the main cause of amputation. The diabetic environment is characterized by prolonged inflammation and abnormal angiogenesis, leading to delayed wound healing. Thus, regulation of inflammation and neovascularization is considered a desirable target for diabetes. The critical purpose of this study was to determine whether systemically administered Substance P (SP)...περισσότερα »
Electrochemical detection of Pseudomonas in wound exudate samples from patients with chronic wounds
Electrochemical detection of Pseudomonas in wound exudate samples from patients with chronic wounds: [image: cover.gif?v=1&s=4e06cdb9cbac42b01d5dfc71] ABSTRACT In clinical practice, point-of-care diagnostic testing has progressed rapidly in the last decade. For the field of wound care, there is a compelling need to develop rapid alternatives for bacterial identification in the clinical setting, where it generally takes over 24 hours to receive a positive identification. Even new molecular and biochemical identification methods require an initial incubation period of several hou... περισσότερα »
Aesthetic rhinoplasty as the final step of nasal reconstruction with a forehead flap
Aesthetic rhinoplasty as the final step of nasal reconstruction with a forehead flap: Abstract BackgroundThe reconstruction of nasal defects represents a difficult challenge for a plastic surgeon as it can be actually difficult to obtain good aesthetic and functional results. Reconstruction needs the use of several complex flaps, including the forehead flap. However, the use of the forehead flap does not give always the optimal aesthetic result. In our opinion, rhinoplasty can optimize the aesthetic outcome and can be used as the last step in nasal reconstruction. MethodsFrom ... περισσότερα »
Subepithelial connective tissue grafts (SeCTG) in conjunction with a coronally advanced flap (CAF) or with tunneling technique (TT)
Patient morbidity and root coverage outcomes after the application of a subepithelial connective tissue graft in combination with a coronally advanced flap or via a tunneling technique: a randomized controlled clinical trial: Abstract Background and objectiveSubepithelial connective tissue grafts (SeCTG) in conjunction with a coronally advanced flap (CAF) or with tunneling technique (TT) are common periodontal procedures with similar indications for the treatment of a denuded root surface; however, it is unclear whether patient discomfort and postoperative morbidity are comparable... περισσότερα »
Osteoinductive potential of 4 commonly employed bone grafts
Osteoinductive potential of 4 commonly employed bone grafts: Abstract ObjectivesGuided bone regeneration (GBR) aims to predictably restore missing bone that has been lost due to trauma, periodontal disease or a variety of systemic conditions. Critical to this procedure is the ability of a bone grafting material to predictably serve as a 3-dimensional scaffold capable of inducing cell and bone tissue in-growth at the material surface. Although all bone grafts are osteoconductive to bone-forming osteoblasts, only a small number of commercially available bone grafts with FDA approval... περισσότερα »
Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis
Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis: Abstract Objective To describe the clinical characteristics and evolution of our series of medication-related osteonecrosis of the jaws (MRONJ) associated with denosumab in osteoporotic patients. Material and Methods We present ten new cases of MRONJ in patients receiving denosumab for osteoporosis. We describe the mean doses of denosumab, previous bisphosphonate intake, and the clinical characteristics associated with the osteonecrosis, such as local contributing factors, symp...περισσότερα »
Association of rapid eye movement sleep behavior disorder with sleep-disordered breathing in Parkinson's disease
Association of rapid eye movement sleep behavior disorder with sleep-disordered breathing in Parkinson's disease: • The correlation between sleep-disordered breathing and rapid eye movement (REM) sleep behavior disorder in Parkinson's disease (PD) was explored.• Sleep-disordered breathing is more frequent and more severe in PD patients with REM sleep behavior disorder than in patients without.• REM sleep behavior disorder increases the risk of hypoxemia during sleep in patients with PD.
Vocational Rehabilitation of Transition-Age Youth with Disabilities: A Propensity-Score Matched Study
Abstract Objective To investigate the employment outcomes of vocational rehabilitation (VR) services for youth with disabilities in a targeted, enhanced, and contract-based secondary transition program as compared to the traditional VR transition services. Methods A population-based study was conducted on 4422 youth with physical, intellectual, learning, mental and hearing disabilities aged 14–21 at application and… Continue reading Vocational Rehabilitation of Transition-Age Youth with Disabilities: A Propensity-Score Matched Study
NMR Concepts
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QFr3MG via IFTTT
Transforming growth factor type beta (TGF- β) requires reactive oxygen species to induce skeletal muscle atrophy
Publication date: Available online 26 January 2016 Source:Cellular Signalling Author(s): Johanna Abrigo, Juan Carlos Rivera, Felipe Simon, Daniel Cabrera, Claudio Cabello-Verrugio Transforming growth factor beta 1 (TGF- β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration, and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by… Continue reading Transforming growth factor type beta (TGF- β) requires reactive oxygen species to induce skeletal muscle atrophy
Efficacy of a CBCT metal artifact reduction algorithm for the detection of peri-implant fenestrations and dehiscences
To assess whether the use of a metal artifact reduction (MAR) algorithm improves the detection of peri-implant fenestrations and dehiscences on CBCT scans. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lVuWA6 via IFTTT
Analysis of the antibacterial effect of an Edwardsiella tarda LuxS inhibitor
LuxS/AI-2 quorum sensing is involved in the virulence of many bacterial pathogens, including the fish pathogen Edwardsiella tarda. In a previous study, we identified a small peptide, 5906, which inhibits E. tarda LuxS activity by binding specifically to LuxS in a manner that probably prevents the formation of functional LuxS homodimer. In the present study,… Continue reading Analysis of the antibacterial effect of an Edwardsiella tarda LuxS inhibitor
Gnathodiaphyseal dysplasia: report of a family with a novel mutation of the gene
Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant disorder characterized by florid osseous dysplasia (FOD) in the jaws, bone fragility, and diaphyseal cortical thickening and bowing of long bones. We present a family with previously undiagnosed GDD. The disorder was identified by the characteristic gnathic and skeletal manifestations in the father. Clinical and radiological examination… Continue reading Gnathodiaphyseal dysplasia: report of a family with a novel mutation of the gene
Differential pain response at local and remote muscle sites following aerobic cycling exercise at mild and moderate intensity
Physical exercise has been shown to inhibit experimental pain response in the post-exercise period. Modulation of the pain system may be differentiated between muscle sites engaging in contractile activity. The purpose of this study was to assess the pain response at remote and local muscle sites following aerobic exercise at different work intensities. Participants included… Continue reading Differential pain response at local and remote muscle sites following aerobic cycling exercise at mild and moderate intensity
Issue Information
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PGMXAg via IFTTT
Differences in sedentary time and physical activity among mothers and children using a movement-to-music video program in the home environment: a pilot study
Measured objectively, less than a quarter of adults and under half of preschool children in Finland meet the physical activity recommendations. Moreover, higher sedentary time among parents (such as watching television) is associated with higher sedentary time of their children. The study introduces an intervention based on reducing sedentary behavior among mothers and their children.… Continue reading Differences in sedentary time and physical activity among mothers and children using a movement-to-music video program in the home environment: a pilot study
Association of rapid eye movement sleep behavior disorder with sleep-disordered breathing in Parkinson’s disease
• The correlation between sleep-disordered breathing and rapid eye movement (REM) sleep behavior disorder in Parkinson’s disease (PD) was explored.• Sleep-disordered breathing is more frequent and more severe in PD patients with REM sleep behavior disorder than in patients without.• REM sleep behavior disorder increases the risk of hypoxemia during sleep in patients with PD.… Continue reading Association of rapid eye movement sleep behavior disorder with sleep-disordered breathing in Parkinson’s disease
Time Trends in Recurrence of Juvenile Nasopharyngeal Angiofibroma: Experience of past 4 decades
Time Trends in Recurrence of Juvenile Nasopharyngeal Angiofibroma: Experience of past 4 decades: An analysis of time distribution of juvenile nasopharyngeal angiofibroma (JNA) from last 4 decades is presented. AbstractBackground An analysis of time distribution of juvenile nasopharyngeal angiofibroma (JNA) from last 4 decades is presented. Methods Sixty recurrences were analysed as per actuarial survival. SPSS software was used to generate Kaplan Myer (KM) curves and time distributions were compared by Logrank, Breslow and Tarone Ware test. Results The overall recurrence rate was 1...περισσότερα »
The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus
The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus: AbstractSALL4 is a transcription factor originally identified as a homeotic gene essential for organ development. Early studies suggested that SALL4 is a useful marker to identify testicular and ovarian germ cell tumors. The aim of the study was to evaluate the diagnostic potential of SALL4 immunohistochemistry. Immunohistochemical staining was performed on a tissue microarray (TMA) with 3966 sa...περισσότερα »
Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis
Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis via Oral Biology Publication date: Available online 27 January 2016 *Source:*Archives of Oral Biology Author(s): Jade Fournier-Larente, Marie-Pierre Morin, Daniel Grenier ObjectivesA number of studies have brought evidence that green tea catechins may contribute to periodontal health. The objective of this study was to investigate the ability of a green tea extract and its principal constituent epigallocatechin-3-gallate (EGCG) to potentiate the antibacterial ... περισσότερα »
Polymorphisms and susceptibility to recurrent tonsillitis in Italian children
polymorphisms and susceptibility to recurrent tonsillitis in Italian children: the tonsils are secondary lymphoid organs fundamental for immune system response against pathogens within the oral cavity. Tonsillitis refers to inflammation of the pharyngeal tonsils that may include the adenoids and the lingual tonsils and that can be acute, recurrent, and chronic. Viral or bacterial infections, as well as immunologic factors are the main trigger to tonsillitis and disease's chronicity: the host immune responses, especially the innate one, could play an important role in susceptibility ... περισσότερα »
Polysomnography results in pediatric patients with mild obstructive sleep apnea: Adenotonsillectomy vs. watchful waiting
Polysomnography results in pediatric patients with mild obstructive sleep apnea: Adenotonsillectomy vs. watchful waiting: There is a lack of consensus and a paucity of data regarding how to best treat pediatric patients with mild obstructive sleep apnea. The objective of our study was to compare outcomes following adenotonsillectomy versus observation in children with mild obstructive sleep apnea based on polysomnography results. AbstractObjective There is a lack of consensus and a paucity of data regarding how to best treat pediatric patients with mild obstructive sleep apnea. Th... περισσότερα »
Treatment of Severe Tracheobronchomalacia: Ten-year experience
Treatment of Severe Tracheobronchomalacia: Ten-year experience: Paediatric tracheobronchomalacia is a rare but potentially serious condition. Severe tracheobronchomalacia requires intervention or operation. This is an evaluation of a ten-year experience at an institution. AbstractIntroduction Paediatric tracheobronchomalacia is a rare but potentially serious condition. Severe tracheobronchomalacia requires intervention or operation. This is an evaluation of a ten-year experience at an institution. Methods In this retrospective study all patients were included that required an inte... περισσότερα »
The Association of Congenital Tracheobronchial Stenosis and Cardiovascular Anomalies
The Association of Congenital Tracheobronchial Stenosis and Cardiovascular Anomalies: Congenital tracheobronchial stenosis (CTBS) is a rare disorder characterized by the presence of focal or diffuse complete tracheal or bronchial cartilage rings resulting in a fixed lumen narrowing. The aim of this study was to expose the association of various cardiovascular (CV) anomalies with various types of CTBS. AbstractObjectives Congenital tracheobronchial stenosis (CTBS) is a rare disorder characterized by the presence of focal or diffuse complete tracheal or bronchial cartilage rings re... περισσότερα »
Production and evaluation of a Spanish version of the LittlEARS® Auditory Questionnaire for the assessment of auditory development in children
Production and evaluation of a Spanish version of the LittlEARS® Auditory Questionnaire for the assessment of auditory development in children: To adapt the LittlEARS® Auditory Questionnaire (LEAQ) into Spanish and evaluate the psychometric properties of the Spanish version of the questionnaire. AbstractBackground and Aims To adapt the LittlEARS® Auditory Questionnaire (LEAQ) into Spanish and evaluate the psychometric properties of the Spanish version of the questionnaire. Methods The LEAQ was translated into Spanish by a back-translation design. Following the Guidelines for Adap... περισσότερα »
Value of Radiofrequency Ablation in The Management of Retropharyngeal Lymphatic Malformation
Value of Radiofrequency Ablation in The Management of Retropharyngeal Lymphatic Malformation: Lymphatic malformations are benign malformations frequently occurring in the head and neck. Retropharyngeal location is rare, can be life threating and its management is particularly challenging. Over a three-year period, three patients presented with symptomatic (dyspnea and/or dysphagia) retropharyngeal lymphatic malformation. All were treated using a radiofrequency ablation of lymphatic malformation through a trans-oral approach. No major complications occurred following the surgery. Dur...περισσότερα »
Τοξικότητα των τοπικών αναισθητικών
Τοξικότητα των τοπικών αναισθητικών στην οδοντιατπική
Espestesin™ Solution for Injection (Articaine HCI & epinephrine HCL)
Anaesthetic efficacy of unilamellar and multilamellar liposomal formulations of articaine in inflamed and uninflamed tissue via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 27 January 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Camila Batista da Silva, Francisco Carlos Groppo, Cleiton Pita dos Santos, Luciano Serpe, Michelle Franz-Montan, Eneida de Paula, José Ranali, Maria Cristina Volpato We compared the efficacy of articaine encapsulated in multilamellar and unilamellar liposomes with that of articaine with epinep... περισσότερα »
Laterognathia
Surgical Management of Laterognathia in Orthofacial Surgery: Abstract IntroductionEach year around the world, various surgical procedures are carried out with the goal of correcting laterognathia; both the intraoral vertical ramus osteotomy (IVRO) and bilateral sagittal split ramus osteotomy (OSB) have been the most used techniques in mandibular surgery. These techniques have advantages and disadvantages; for example the advantages of the OSB include: increased coefficient of friction between bony segments, for both the forward and the retroposition, as well as decrease in the tim...περισσότερα »
Differences in sedentary time and physical activity among mothers and children using a movement-to-music video program in the home environment: a pilot study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Measured objectively, less than a quarter of adults and under half of preschool children in Finland meet the physical activity recommendations. Moreover, higher sedentary time among parents (such as watching television) is associated with higher sedentary time of their children. The study introduces an intervention based on reducing sedentary behavior among mothers and their children. […]
Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Abstract Objective To describe the clinical characteristics and evolution of our series of medication-related osteonecrosis of the jaws (MRONJ) associated with denosumab in osteoporotic patients. Material and Methods We present ten new cases of MRONJ in patients receiving denosumab for osteoporosis. We describe the mean doses of denosumab, previous bisphosphonate intake, and the clinical characteristics […]
Late Ordovician (late Katian) cryptospores and chitinozoans from the Mannan-1 borehole, south Tarim Basin, China
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Palaeoworld Author(s): Peng Tang, Yi Wang, Hong-He Xu, Qing Jiang, Zhi-Lin Yang, Jia-Zheng Zhan, Xiao-Le Zhang Well-preserved cryptospore and chitinozoan assemblages were recovered from the Tierekawati Formation (late Katian, Late Ordovician) of the Mannan-1 borehole, south Tarim basin (Tarim Block), China. The chitinozoan assemblage is low in abundance […]
Hospice care: Comforting the terminally ill
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1FJ0GzP via IFTTT
Späte Vaterschaft ist doch kein Problem – oder?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Fertilität bei Männern Eine Elternschaft im späteren Lebensalter wird von vielen Menschen als vorteilhaft wahrgenommen, da die Lebensbedingungen in vielerlei Hinsicht häufig stabiler sind. Auch gibt es Männer, die eine zweite Familie gründen möchten. Einige biologische Besonderheiten der späten Vaterschaft im Überblick. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PGMUEA via IFTTT
Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Corinne S. Happel, Kelly D. Stone, Alexandra F. Freeman, Nirali N. Shah, Angela Wang, Jonathan J. Lyons, Pamela A. Guerrerio, Dennis D. Hickstein, Helen C. Su from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Tp9wZJ via IFTTT
Vocational Rehabilitation of Transition-Age Youth with Disabilities: A Propensity-Score Matched Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Abstract Objective To investigate the employment outcomes of vocational rehabilitation (VR) services for youth with disabilities in a targeted, enhanced, and contract-based secondary transition program as compared to the traditional VR transition services. Methods A population-based study was conducted on 4422 youth with physical, intellectual, learning, mental and hearing disabilities aged 14–21 at application and […]
Ask Howard Anything / January 2016
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
NAD CEO Howard A. Rosenblum gives an update about streaming media in the air. The AHA Series is also available at http://www.nad.org/AHA. If you’re reading this from your moible, please view the video here. NAD’s Press Release about Gogo’s Agreement to do 100% Captioning (Source: National Association of the Deaf) from #Medicine-SfakianakisAlexandros via o.lakala70 on […]
Value of Radiofrequency Ablation in The Management of Retropharyngeal Lymphatic Malformation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Lymphatic malformations are benign malformations frequently occurring in the head and neck. Retropharyngeal location is rare, can be life threating and its management is particularly challenging. Over a three-year period, three patients presented with symptomatic (dyspnea and/or dysphagia) retropharyngeal lymphatic malformation. All were treated using a radiofrequency ablation of lymphatic malformation through a trans-oral approach. […]
Production and evaluation of a Spanish version of the LittlEARS® Auditory Questionnaire for the assessment of auditory development in children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
To adapt the LittlEARS® Auditory Questionnaire (LEAQ) into Spanish and evaluate the psychometric properties of the Spanish version of the questionnaire. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZUABUA via IFTTT
Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis
Publication date: Available online 27 January 2016 *Source:*Archives of Oral Biology Author(s): Jade Fournier-Larente, Marie-Pierre Morin, Daniel Grenier ObjectivesA number of studies have brought evidence that green tea catechins may contribute to periodontal health. The objective of this study was to investigate the ability of a green tea extract and its principal constituent epigallocatechin-3-gallate (EGCG) to potentiate the antibacterial effects of antibiotics (metronidazole, tetracycline) against Porphyromonas gingivalis, and to modulate the adherence to oral epithelial cells ... περισσότερα »
Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer
Inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating inflammatory cells mediate processes associated with progression, immune suppression, promotion of neoangiogenesis and lymphangiogenesis, remodeling of extracellular matrix, invasion and metastasis, and, lastly, the inhibition of vaccine-induced antitumor T cell response. Accumulating evidence indicates a critical role of myeloid cells in the pathophysiology of human cancers. In contrast to the well-cha...περισσότερα »
Efficacy of Human Adipose Tissue-Derived Stem Cells on Neonatal Bilirubin Encephalopathy in Rats
Abstract Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in 7-day-old rats to induce haemolysis and then infused sulfisoxazole into the same rats at day 9 to block bilirubin binding sites in the albumin. We have investigated the effectiveness of human adiposity-derived stem cells as a therapeutic paradigm for perinata... περισσότερα »
The Spaces Between
"As we take, in fact, a general view of the wonderful stream of our consciousness, what strikes us first is this different pace of its parts. Like a bird's life, it seems to be made of an alternation of flights and perchings."— William James, The Principles of Psychology (1890) I grew up in a… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1KclUdG via IFTTT
Neurobiologic Advances from the Brain Disease Model of Addiction
This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. In the past two decades, research has increasingly supported the view that addiction is a disease of the brain. Although the brain disease model of addiction… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1lVnWDm via IFTTT
Opioid Prescribing for Chronic Pain — Achieving the Right Balance through Education
In recent decades, the United States has seen a dramatic increase in opioid prescribing for chronic pain. That growth has been associated with increasing misuse of prescription opioids and has led to increases in deaths due to unintentional opioid overdose and in the number of people seeking… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1KclTGA via IFTTT
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allo... περισσότερα »
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allo... περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Antithyroid Drug Side Effects... περισσότερα »
The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients
Abstract There is very little published information regarding the prognostic value of hemoglobin (Hb) levels combined with smoking on the survival of patients with nasopharyngeal carcinoma (NPC), and the interactions between them remain unclear. A total of 2440 NPC patients were confirmed, and multivariate analysis was performed to identify valuable prognostic Hb levels in the… Continue reading The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients
The fa2 gene and molecular markers mapping in the gp segment of the Pisum linkage group V
Abstract Review studies on the world Pisum genetic resources have shown that stem fasciation is controlled by three loci, i.e., fa1 (LGIV; Wt 10006 – type line of the Polish Gene Bank), fa2 (LGV, the line Wt 12185), and fas (LGIII, the line Shtambovii). Outstanding advantages of this character (e.g., pods gathered in upper part… Continue reading The fa2 gene and molecular markers mapping in the gp segment of the Pisum linkage group V
Redox-coupled substrate water reorganization in the active site of photosystem II – the role of calcium in substrate water delivery
Publication date: Available online 27 January 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics Author(s): Ilke Ugur, A. William Rutherford, Ville R.I. Kaila Photosystem II (PSII) catalyzes light-driven water splitting in nature and is the key enzyme for energy input into the biosphere. Important details of its mechanism are not well understood. In order to… Continue reading Redox-coupled substrate water reorganization in the active site of photosystem II – the role of calcium in substrate water delivery
Aging-related renal injury and inflammation are associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice
Abstract Background and Aims The predominant distribution of the antiaging Klotho protein in both the kidneys and brain may point to its essential role in protecting against dysfunction of the kidney-brain axis during the aging process. Our previous study showed that the downregulation of Klotho was involved in aging-related cognitive impairment in aged senescence-accelerated mouse… Continue reading Aging-related renal injury and inflammation are associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice
Children’s comprehension of an unfamiliar speaker accent: a review
Abstract Background The effect of speaker accent on listeners’ comprehension has become a key focus of research given the increasing cultural diversity of society and the increased likelihood of an individual encountering a clinician with an unfamiliar accent. Aims To review the studies exploring the effect of an unfamiliar accent on language comprehension in typically… Continue reading Children’s comprehension of an unfamiliar speaker accent: a review
Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect
Abstract Background The elderly are vulnerable to hypothermia and have a higher risk of cardiovascular events induced by marked increases in oxygen consumption due to shivering. Five-hydroxytryptamine-3 (5-HT3) receptor antagonists have been previously reported to reduce post-anesthesia shivering. Aim In the present study, the authors investigated the effects of palonosetron, a new-generation 5-HT3 antagonist, on… Continue reading Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were… Continue reading Prostate Cancer Susceptibility in Men of African Ancestry at 8q24
Progesterone modulates endothelial progenitor cell (EPC) viability through the CXCL12/CXCR4/PI3K/Akt signalling pathway
Abstract Objectives Progesterone treatment can effectively increase levels of circulating endothelial progenitor cells (EPCs) and improve neurological functional outcome in a traumatic brain injury (TBI) rat model. However, the mechanisms of progesterone’s effects on EPC viability remain elusive. The CXCL12/CXCR4 (CXC chemokine ligand 12/CXC chemokine receptor 4) signalling pathway regulates cell proliferation; we hypothesize that… Continue reading Progesterone modulates endothelial progenitor cell (EPC) viability through the CXCL12/CXCR4/PI3K/Akt signalling pathway
Aging-related decrements during specific phases of the dual-task Timed Up-and-Go test
Abstract Background It is unclear how young and older adults modulate dual-task mobility under changing postural challenges. Aim To examine age-related changes in dual-task processing during specific phases of dual-task Timed Up-and-Go (TUGdual-task). Method Healthy young and older adults performed the Timed Up-and-Go (TUG) with the following dual-task conditions: (1) serial-three subtractions, (2) carrying cup… Continue reading Aging-related decrements during specific phases of the dual-task Timed Up-and-Go test
PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations
Mosaic truncating mutations in the protein phosphatase, Mg2+/Mn2+-dependent, 1D (PPM1D) gene have recently been reported with a statistically significantly greater frequency in lymphocyte DNA from ovarian cancer case patients compared with unaffected control patients. Using massively parallel sequencing (MPS) we identified truncating PPM1D mutations in 12 of 3236 epithelial ovarian cancer (EOC) case patients (0.37%)… Continue reading PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations
Contrat unique : une solution et un risque pour la recherche à promotion industrielle. Propositions de « sortie de crise »
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Balance des fluides et sevrage de la ventilation mécanique
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Résumé La surcharge volémique est fréquemment rencontrée en réanimation, notamment chez les patients septiques et/ou ventilés. La surcharge volémique est associée à une prolongation de la durée de ventilation mécanique en général et du sevrage en particulier. Il s’agit d’un facteur favorisant de la dysfonction cardiovasculaire du sevrage impliqué dans l’échec de l’épreuve de ventilation […]
Mental Health among displaced Syrians: findings from the Syria Public Health Network
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Public health, politics and the stigma of mass hysteria: lessons from an outbreak of unusual illness
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: a brief history.
[image: http:--linkinghub.elsevier.com-ihub-imag] Drug Discov Today. Authors: Scotece M, Conde J, Abella V, Lopez V, Pino J, Lago F, Smith AB, Gómez-Reino JJ, Gualillo O Abstract Extra-virgin olive oil (EVOO), a principal component of the Mediterranean diet (Med diet), is one of the most ancient known foods and has long been associated with health benefits. Many phenolic compounds extracted from Olea europea L. have attracted attention since their discovery. Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseas... περισσότερα »
Trimethylamine-The Extracorporeal Envoy.
Trimethylamine-The Extracorporeal Envoy.: *Trimethylamine-The Extracorporeal Envoy.* Chem Senses. 2016 Jan 24; Authors: Mitchell SC, Smith RL Abstract One of the most widespread and efficient mechanisms that has evolved to enable communication between discrete and spatially separate living organisms is the use of specific chemical messengers. The organoleptic properties of certain molecules, even at concentrations that do not necessarily evoke a conscious response, have been exploited to transmit information across relatively large distances. The trimethylated derivative of ammo...περισσότερα »
Central sleep apnea in adult patients with chronic kidney disease
A systematic review of central sleep apnea in adult patients with chronic kidney disease: Abstract BackgroundObstructive sleep apnea has been widely studied in patients with chronic renal insufficiency; however only a limited number of studies have reviewed the association between central sleep apnea (CSA) and chronic kidney disease (CKD). The objectives of this systematic review were to assess the prevalence of CSA in and its association with CKD in adult patients and to determine if inclusion of the central hypopnea index affected the reported rates for the prevalence of CSA in ... περισσότερα »
Self-assembled gemcitabine – gadolinium nanoparticles for MRI and cancer therapy
Self-assembled gemcitabine – gadolinium nanoparticles for magnetic resonance imaging and cancer therapy via Acta Biomaterialia Publication date: Available online 27 January 2016 *Source:*Acta Biomaterialia Author(s): Lele Li, Rong Tong, Mengyuan Li, Daniel S. Kohane Nanoparticles with combined diagnostic and therapeutic functions are promising tools for cancer diagnosis and treatment. Here, we demonstrate a theranostic nanoparticle that integrates an active gemcitabine metabolite and a gadolinium-based magnetic resonance imaging agent via a facile supramolecular self-assembly synthesis... περισσότερα »
A Porcine Dermal Biologic Scaffold
Properties and In-Vivo Remodeling of a Porcine Dermal Biologic Scaffold via Acta Biomaterialia Publication date: Available online 27 January 2016 *Source:*Acta Biomaterialia Author(s): Christopher L. Dearth, Timothy J. Keane, Christopher A. Carruthers, Janet E. Reing, Luai Huleihel, Christian A. Ranallo, Elizabeth W. Kollar, Stephen F. Badylak Biologic scaffolds composed of extracellular matrix are commonly used in a variety of surgical procedures. The Food and Drug Administration typically regulates biologic scaffolds as medical devices, thus requiring terminal sterilization prior to ... περισσότερα »
Differentiation of mesenchymal stem cells for cartilage tissue engineering
: Individual and synergetic effects of three-dimensional environment and mechanical loading via Acta Biomaterialia Publication date: Available online 27 January 2016 *Source:*Acta Biomaterialia Author(s): J.A. Panadero, S. Lanceros-Mendez, J.L. Gomez Ribelles Chondrogenesis of dedifferentiated chondrocytes and mesenchymal stem cells is influenced not only by soluble molecules like growth factors, but also by the cell environment itself. The latter is achieved both through mechanical cues – which act as stimulation factor and influences nutrient transport - and through adhesion to extra... περισσότερα »
Oculomotor Deficits after Chemotherapy in Childhood
Oculomotor Deficits after Chemotherapy in Childhood: by Einar-Jón Einarsson, Mitesh Patel, Hannes Petersen, Thomas Wiebe, Måns Magnusson, Christian Moëll, Per-Anders Fransson Advances in the diagnosis and treatment of pediatric malignancies have substantially increased the number of childhood cancer survivors. However, reports suggest that some of the chemotherapy agents used for treatment can cross the blood brain barrier which may lead to a host of neurological symptoms including oculomotor dysfunction. Whether chemotherapy at young age causes oculomotor dysfunction later in life... περισσότερα »
NIMRAD (A Randomised Placebo-controlled Trial of Synchronous NIMorazole Versus RADiotherapy Alone in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Not Suitable for Synchronous Chemotherapy or Cetuximab)
NIMRAD (A Randomised Placebo-controlled Trial of Synchronous NIMorazole Versus RADiotherapy Alone in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Not Suitable for Synchronous Chemotherapy or Cetuximab): *Condition*: Head and Neck Squamous Cell Carcinoma *Interventions*: Drug: Nimorazole; Radiation: Radiotherapy *Sponsor*: Christie Hospital NHS Foundation Trust
MGCD516 in Patients With Advanced Cancer
Phase 1/1b Study of MGCD516 in Patients With Advanced Cancer: *Condition*: Advanced Cancer *Intervention*: Drug: MGCD516 *Sponsor*: Mirati Therapeutics Inc. MGCD516 is a receptor tyrosine kinase (RTK) inhibitor shown in preclinical models to inhibit a closely related spectrum of RTKs including MET, AXL, MER, and members of the VEGFR, PDGFR, DDR2, TRK and Eph families. In this study, MGCD516 is orally administered to patients with advanced solid tumor malignancies to evaluate its safety, pharmacokinetic, metabolism, pharmacodynamic and clinical activity profiles. During the ... περισσότερα »
Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors
A Study of Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors: *Conditions*: Selected Advanced Solid Tumors; Non-small Cell Lung Cancer; Melanoma; Head and Neck Cancer; Gastric Cancer; Gastroesophageal Cancer; Urothelial Cancer; Triple Negative Breast Cancer *Interventions*: Drug: MEDI4736; Drug: INCB024360 *Sponsors*: Incyte Corporation; MedImmune LLC ArmsAssigned InterventionsExperimental: MEDI4736 + INCB024360 MEDI4736 at selected dose levels every 2 weeks + INCB024360 25 mg BID as starting ...περισσότερα »
PCA062 in pCAD-positive Tumors
PCA062 in pCAD-positive Tumors: *Condition*: Triple Negative Breast Cancer, Head & Neck Cancer, Esophageal Cancer *Intervention*: Drug: PCA062 *Sponsor*: Novartis Pharmaceuticals ArmsAssigned InterventionsExperimental: Triple Negative Breast CancerDrug: PCA062Experimental: Head and Neck CancerDrug: PCA062Experimental: Esophageal CancerDrug: PCA062
Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma
Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma: *Condition*: Cognitive Impairment *Intervention*: Drug: TSH-suppressive therapy *Sponsors*: The Affiliated Hospital of Inner Mongolia Medical University; National Natural Science Foundation of China Thyroid carcinoma is the common endocrine system malignant neoplasm. At present it has become the malignant neoplasm of fastest growing incidence rate. More than 90% thyroid carcinoma is thyroid differentiated carcinoma（DTC）. Postoperative oral L-thyroxine suppressing t... περισσότερα »
Prevalence of attention deficit hyperactivity disorder among urban school children
Prevalence of attention deficit hyperactivity disorder among urban school children: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Rajeshwari Mannapur, Govindaraj Munirathnam, Mallapa Hyarada, Siva Saranappa Sri Bylagoudar. Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood onset psychiatric disorders. Prevalence among school children varies from 1% to 20%.Western literature on this disorder has grown but in India only few studies have been done. Evaluation of prevalence of ADHD in school age children ca... περισσότερα »
Knowledge, attitude and practice of parents towards antibiotic usage and its resistance
Knowledge, attitude and practice of parents towards antibiotic usage and its resistance: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Balaji Chinnasami, Kanimozhi Sadasivam, Balaji Ramraj, Sekar Pasupathy. Background: To assess the knowledge, attitude and practices about rational antibiotic usage and antibiotic resistance among parents attending a hospital based setting in Tamilnadu. Methods: The study was a cross-sectional quantitative study in which four hundred and ninety one respondents, majority of them aged 20-50 years participated. A standa... περισσότερα »
Van Wyk Grumbach syndrome : long standing hypothyroidism, precocious puberty, Ovarian cysts and delayed bona age
Van Wyk Grumbach syndrome: a case report: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Ravi Bhatia, Gunjan Bhatia. Van Wyk Grumbach Syndrome is characterized by long standing hypothyroidism, precocious puberty, Ovarian cysts and delayed bona age. We present a case of a 12 year old female who presented with Short stature and precocious puberty. The Patient responded well to L- thyroxine therapy.
Osteogenesis imperfecta type 111
Osteogenesis imperfecta type 111: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Rugmini Kamalammal,Venkatamurthy M, Aditya Kumar Bandari. Osteogenesis Imperfecta is a rare inherited disorder affecting connective tissue integrity, characterized by bone fragility of varying severity ranging from lethal forms to those with very minimal features. Here, we are presenting a case of 3 months old infant with multiple fractures sustained during routine handling .Baby was diagnosed as OI type III, which is the most severe non-lethal form of the disease. Earl... περισσότερα »
Epstein-Barr virus associated hemophagocytic lymphohistiocytosis presenting with lymphadenopathy diagnosed as Kikuchi-Fujimoto disease: a case report from South India
Epstein-Barr virus associated hemophagocytic lymphohistiocytosis presenting with lymphadenopathy diagnosed as Kikuchi-Fujimoto disease: a case report from South India: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Karthik Prabhu Ramaraj, Ravikumar T., Venkat Reddy. We report a rare case of hemophagocytosis and Kikuchi-Fujimoto disease associated with Epstein-barr virus infection, presenting in an eight year old boy hailing from south India. The child presented with fever and cervical lymphadenopathy. Bone marrow aspirate revealed hemophagocytosis. ...περισσότερα »
Infantile hemangiopericytoma with recurrence in the subcutaneous tissues of head and neck
Infantile hemangiopericytoma with recurrence: a case report: 2016-01-27T23-07-22Z *Source:* International Journal of Contemporary Pediatrics Durgashankar Jaipal, Sunita Kulhari, Mohit Gupta, Neelu Gupta. Infantile hemangiopericytoma is rare vascular tumour in infant. These tumour usually solid, occur in the subcutaneous tissues of head and neck. Mainly it has a benign behaviour but recurrence and metastasis also seen. Herein, we report on one full term female child, delivered with a nodular swelling present behind the right ear. Complete surgical excision with safety margins was p... περισσότερα »
Firazyr 30 mg ενέσιμο διάλυμα σε προγεμισμένη σύριγγα.Η ικατιβάντη (icatibant) είναι ένας ισχυρός, ειδικός και εκλεκτικός πεπτιδομιμητικός ανταγωνιστής των β2-υποδοχέων βραδυκινίνης. Πρόκειται για ένα συνθετικό δεκαπεπτίδιο του οποίου η δομή είναι παρόμοια με αυτήν της βραδυκινίνης, αλλά με 5 μη πρωτεϊνογενή αμινοξέα. Η ικατιβάντη ενδείκνυται για τη συμπτωματική θεραπεία οξέων επεισοδίων κληρονομικού αγγειοοιδήματος σε ενήλικες (με ανεπάρκεια του αναστολέα της C1-εστεράσης).
Η ικατιβάντη (icatibant) είναι ένας ισχυρός, ειδικός και εκλεκτικός πεπτιδομιμητικός ανταγωνιστής των β2-υποδοχέων βραδυκινίνης. Πρόκειται για ένα συνθετικό δεκαπεπτίδιο του οποίου η δομή είναι παρόμοια με αυτήν της βραδυκινίνης, αλλά με 5 μη πρωτεϊνογενή αμινοξέα. Η ικατιβάντη ενδείκνυται για τη συμπτωματική θεραπεία οξέων επεισοδίων κληρονομικού αγγειοοιδήματος σε ενήλικες (με ανεπάρκεια του αναστολέα της C1-εστεράσης). http://www.ifet.gr/drugs/orphans/firazyr-el.pdf 1 ΠΑΡΑΡΤΗΜΑ Ι ΠΕΡΙΛΗΨΗ ΤΩΝ ΧΑΡΑΚΤΗΡΙΣΤΙΚΏΝ ΤΟΥ ΠΡΟΪΟΝΤΟΣ 2 1. ΟΝΟΜΑΣΙΑ ΤΟΥ ΦΑΡΜΑΚΕΥΤΙΚΟΥ ΠΡΟΪΟΝΤΟΣ Firazyr 30 mg εν... περισσότερα »
Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system
Abstract The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been extensively used to edit the genome of several organisms. However, most mutations reported to date have been are indels, resulting in multiple mutations and numerous alleles in targeted genes. In the present study, a large deletion of 105 kb in the *TYR* (tyrosinase) gene was generated in rabbit via a dual sgRNA-directed CRISPR/Cas9 system. The typical symptoms of albinism accompanied significantly decreased expression of *TYR* in the *TYR* knockout rabbits. Furthermore, the same genotype and albinism phen... περισσότερα »
Understanding how differentiation is maintained: lessons from the Drosophila brain
Abstract The ability to maintain cells in a differentiated state and to prevent them from reprogramming into a multipotent state has recently emerged as a central theme in neural development as well as in oncogenesis. In the developing central nervous system (CNS) of the fruit fly *Drosophila*, several transcription factors were recently identified to be required in postmitotic cells to maintain differentiation, and in their absence, mature neurons undergo dedifferentiation, giving rise to proliferative neural stem cells and ultimately to tumor growth. In this review, we will highl... περισσότερα »
Hommage à Georges Salamon
Publication date: Available online 27 January 2016 Source:Journal of Neuroradiology Author(s): C. Manelfe from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lV8iId via IFTTT
Dietary fat and corticosterone levels are contributing factors to meal anticipation
Daily restricted access to food leads to the development of food anticipatory activity and metabolism, which depends upon an as yet unidentified food-entrainable oscillator(s). A pre-meal anticipatory peak in circulating hormones including corticosterone is elicited by daily restricted feeding. High fat feeding is associated with elevated levels of corticosterone with disrupted circadian rhythms and a… Continue reading Dietary fat and corticosterone levels are contributing factors to meal anticipation
Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials
Abstract Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library… Continue reading Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials
The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review and network meta-analysis
Acute diarrhea and acute gastroenteritis (AD/AGE) are common among children in low- and middle-income countries (LMIC) and high-income countries (HIC). Supportive therapy including maintaining feeding, prevent… from Medicine via xlomafota13 on Inoreader http://ift.tt/1ScNPNA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20ub86C via IFTTT
Usefulness of PET Imaging to Guide Treatment Options in Gliomas
Opinion statement Magnetic resonance imaging (MRI) is the gold standard guiding diagnostic and therapeutic management in glioma with its high resolution and possibility to depict blood-brain-barrier disruption when contrast medium is applied. In light of the shifting paradigms revealing distinct tumor subtypes based on the molecular and genetic characterization and increasing knowledge about the variability… Continue reading Usefulness of PET Imaging to Guide Treatment Options in Gliomas
Episodic future thinking: the role of working memory and inhibition on age-related differences
Abstract The ability to remember past events and imagine future events (episodic future thinking—EFT) has been shown to decline with aging. However, only few studies have analyzed the cognitive mechanisms involved in EFT in both young and older adults. The present study examined the role of working memory and inhibition on age-related differences between young… Continue reading Episodic future thinking: the role of working memory and inhibition on age-related differences
Contrat unique : une solution et un risque pour la recherche à promotion industrielle. Propositions de « sortie de crise »
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Endothelin Therapeutics in Cancer-Where Are We?
In human cancers, the autocrine and paracrine loop mediated by the aberrantly activation of endothelin-1 receptor elicits pleiotropic effects, preferentially mediated by the scaffold protein β-arrestin 1 (β-arr1), on tumour cells and on the host microenvironment, providing a strong rationale for targeting ET-1 receptors. This review describes the most up-to-date preclinical and clinical results obtained… Continue reading Endothelin Therapeutics in Cancer-Where Are We?
Effect of transcutaneous acupoint electrical stimulation on propofol sedation: an electroencephalogram analysis of patients undergoing pituitary adenomas resection
Transcutaneous acupoint electrical stimulation (TAES) as a needleless acupuncture has the same effect like traditional manual acupuncture. The combination of TAES and anesthesia has been proved valid in enhanc… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SkOWsH via IFTTT
School-based intervention for the prevention of HPV among adolescents: a cluster randomised controlled study
Objective To improve primary prevention of human papillomavirus (HPV) infection by promoting vaccination and increased condom use among upper secondary school students. Design Cluster randomised controlled trial. Setting 18 upper secondary schools in Sweden. Participants Schools were first randomised to the intervention or the control group, after which individual classes were randomised so as to… Continue reading School-based intervention for the prevention of HPV among adolescents: a cluster randomised controlled study
Berinert® 500 μονάδες
https://www.sfee.gr/spcs/wp-content/uploads/2014/08/CSL_Behring_MEPE/Berinert_P.SV_.INJ_.F_500_SPC-070709.pdf 1. ΟΝΟΜΑΣΙΑ ΤΟΥ ΦΑΡΜΑΚΕΥΤΙΚΟΥ ΠΡΟΪΟΝΤΟΣ Berinert® 500 μονάδες Κόνις και διαλύτης για ενέσιμο διάλυμα / διάλυμα προς έγχυση. 2. ΠΟΙΟΤΙΚΗ ΚΑΙ ΠΟΣΟΤΙΚΗ ΣΥΝΘΕΣΗ Δραστική ουσία: αναστολέας της C1-εστεράσης, ανθρώπινος Το Berinert περιέχει 500 μονάδες αναστολέα της C1-εστεράσης ανά φιαλίδιο για ενέσιμα. 1 U αντιστοιχεί σε δραστικότητα του αναστολέα της C1-εστεράσης σε 1 ml νωπού κιτριούχου πλάσματος υγιών δοτών, 1 U αντιστοιχεί σε 6 μονάδες Levy-Lepow. Το προϊόν περιέχει 50 U/ml α... περισσότερα »
Φάρμακα που χρησιμοποιούνται στο κληρονομικό αγγειοοίδημα
ΚωδικόςΤίτλος B06AC01C1-inhibitor, plasma derived B06AC02Icatibant B06AC03 Ecallantide B06AC04Conestat alfa Δραστικές ουσίες ομάδαςΔραστική ουσίαΣύντομη περιγραφή Αναστολέας της C1-εστεράσης Ο αναστολέας της C1-εστεράσης είναι μια γλυκοπρωτεΐνη του πλάσματος με μοριακό βάρος 105 kD, και τμήμα υδατανθράκων 40%. Ο αναστολέας της C1-εστεράσης ανήκει στο σύστημα (σερπίνης) αναστολέα σερίνης-πρωτεάσης του ανθρώπινου πλάσματος. Ο αναστολέας της C1-εστεράσης φράσσει την κλασσική οδό του συστήματος συμπληρώματος, αδρανοποιώντας τα ενζυμικώς ενεργά συστατικά C1s και C1r. Τέλος, ο αναστολέας τη... περισσότερα »
Unklare Ulzerationen an der unteren Extremität bei einem 30-jährigen Mann
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The use of dermatoscopy in diagnosis and therapy of nonmelanocytic skin cancer
Summary Today, dermatoscopy is an integral part of every clinical skin examination, as it markedly enhances the early detection of melanocytic and nonmelanocytic skin cancer (NMSC) compared to naked-eye inspection. Besides its diagnostic use, this noninvasive method is increasingly important in the selection of as well as the response assessment to various therapies used for NMSC, including basal cell carcinoma, actinic keratoses, squamous cell carcinoma, and also rare tumors such as Merkel cell carcinoma, angiosarcoma, or dermatofibrosarcoma protuberans. Thus, dermatoscopy is a v... περισσότερα »
Basal cell carcinomas with perineural invasion: a clinical-therapeutic and histological challange
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Human bites – the gap in our dermatology textbooks
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Kleine nicht-follikuläre weiße Papeln auf den Handrücken und in der Unterkieferregion
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Deutsche Leitlinie zur Diagnostik und Therapie der zirkumskripten Sklerodermie
Zusammenfassung Bei der zirkumskripten Sklerodermie handelt es sich um eine heterogene Gruppe von sklerotischen Erkrankungen der Haut mit je nach Subtyp, Schweregrad und Lokalisation möglicher Beteiligung von hautnahen Strukturen wie Fettgewebe, Muskulatur, Gelenke und Knochen. Dies ist eine Aktualisierung der bereits bestehenden deutschen Leitlinie der AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Wissenschaften) mit dem Klassifizierungsgrad S2k. Die Leitlinie gibt einen Überblick zur Definition, Epidemiologie, Klassifikation, Pathogenese, Labordiagnostik, Histop... περισσότερα »
Österreichische Gesellschaft für Dermatologie und Venerologie (ÖGDV)
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Komplette Abheilung einer febrilen ulzeronekrotischen Mucha-Habermann-Krankheit unter Therapie mit Infliximab
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Palmoplantar keratodermas: clinical and genetic aspects
Summary Palmoplantar keratodermas comprise a diverse group of acquired and hereditary disorders marked by excessive thickening of the epidermis of palms and soles. Early onset and positive family history suggest a genetic cause. While hereditary forms of palmoplantar keratoderma (PPK) may represent the sole or dominant clinical feature, they may also be associated with other ectodermal defects or extracutaneous manifestations. In recent years, much progress has been made in deciphering the genetic basis of PPK, which has led to the emergence of new disorders and syndromes. The elu...περισσότερα »
Perspektive
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Kongresskalender 2016
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Der Einsatz der Dermatoskopie in der Diagnose und Therapie von nichtmelanozytären Hautkrebsformen
Zusammenfassung Die Dermatoskopie stellt heute einen integrativen Teil jeder klinischen Hautkrebsuntersuchung dar, da sie die Früherkennung von melanozytären und nichtmelanozytären Hautkrebsformen im Vergleich zur Untersuchung mit dem bloßen Auge deutlich verbessert. Neben ihrem diagnostischen Einsatz nimmt diese nichtinvasive Methode auch eine zunehmende Rolle in der Wahl und Bewertung unterschiedlicher Therapien von nichtmelanozytären Hauttumoren wie Basalzellkarzinomen, aktinischen Keratosen, Plattenepithelkarzinomen, aber auch seltenen Tumoren wie dem Merkelzellkarzinom, Angios... περισσότερα »
Keratosis palmoplantaris: klinische und genetische Aspekte
Zusammenfassung Zu den Palmoplantarkeratosen (PPK) gehören verschiedene erworbene und angeborene Störungen, die durch übermäßige Verdickung der Epidermis an Handflächen und Fußsohlen gekennzeichnet sind. Ein früher Ausbruch und eine positive Familienanamnese weisen auf eine genetische Ursache der PPK hin. Eine angeborene PKK kann das einzige oder das dominante klinische Merkmal darstellen oder sie kann von anderen ektodermalen Dysplasien oder extrakutanen Symptomen begleitet sein. In der letzten Zeit wurden bei der Entschlüsselung der genetischen Grundlagen der PKK deutliche Fortsc... περισσότερα »
Field-Based High-Throughput Plant Phenotyping Reveals the Temporal Patterns of Quantitative Trait Loci Associated with Stress-Responsive Traits in Cotton
The application of high-throughput plant phenotyping (HTPP) to continuously study plant populations under relevant growing conditions creates the possibility to more efficiently dissect the genetic basis of dynamic adaptive traits. Towards this end, we employed a field-based HTPP system that deployed sets of sensors to simultaneously measure canopy temperature, reflectance, and height on a cotton (*Gossypium hirsutum* L.) recombinant inbred line mapping population. The evaluation trials were conducted under well-watered and water-limited conditions in a replicated field experiment ... περισσότερα »
Increasing Genome Sampling and Improving SNP Genotyping for Genotyping-by-Sequencing with new Combinations of Restriction Enzymes
Genotyping-by-sequencing (GBS) has emerged as a useful genomic approach for exploring genome-wide genetic variation. However, GBS commonly samples a genome unevenly and can generate a substantial amount of missing data. These technical features would limit the power of various GBS-based genetic and genomic analyses. Here we present software called *IgCoverage* for *in silico* evaluation of genomic coverage through GBS with an individual or a pair of restriction enzymes on one sequenced genome and report a new set of 21 restriction enzyme combinations that can be applied to enhance ... περισσότερα »
Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility
DNA transposons and retroviruses are important transgenic tools for genome engineering. An important consideration affecting the choice of transgenic vector is their insertion site preferences. Previous large-scale analyses of Ds transposon integration sites in plants were done on the basis of reporter gene expression or germline transmission, making it difficult to discern vertebrate integration preferences. Here, we compare over 1300 Ds transposon integration sites in zebrafish, with Tol2 transposon and retroviral integration sites. Genome-wide analysis shows that Ds integration... περισσότερα »
Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses is Toxic to Caenorhabditis elegans
Inappropriate activation of innate immune responses in intestinal epithelial cells underlies the pathophysiology of inflammatory disorders of the intestine. Here we examine the physiological effects of immune hyperactivation in the intestine of the nematode *C. elegans*. We previously identified an immunostimulatory xenobiotic that protects *C. elegans* from bacterial infection by inducing immune effector expression via the conserved p38 MAP kinase pathway, but was toxic to nematodes developing in the absence of pathogen. To investigate a possible connection between the toxicity a...περισσότερα »
Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin Protein Structure and Folding
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The structural similarity between the defensins and scorpion neurotoxins suggests that they might have evolved from a common ancestor. However, there is no direct experimental evidence demonstrating functional linkage between scorpion neurotoxin and defensin. The scorpion defensin BmKDfsin4 from Mesobuthus martensii Karsch contains 37 amino acid residues and a conserved CSα/β structural fold. The recombinant […]
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin {mu}O{section}-GVIIJ Neurobiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Cone snail toxins are well-known blockers of voltage-gated sodium channels, a property that is of broad interest in biology and therapeutically in treating neuropathic pain and neurological disorders. While most conotoxin channel blockers function by direct binding to a channel and disrupting its normal ion movement, conotoxin μO§-GVIIJ channel blocking is unique, using both favorable […]
Post-endocytotic deubiquitination and degradation of the metabotropic {gamma}-aminobutyric acid receptor by the ubiquitin specific protease 14 Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Mechanisms controlling the metabotropic γ-aminobutyric acid receptor (GABAB) cell surface stability are still poorly understood. In contrast with many other G protein-coupled receptors (GPCR), it is not subject to agonist-promoted internalization, but is constitutively internalized and rapidly down-regulated. In search of novel interacting proteins regulating receptor fate, we report that the ubiquitin specific protease 14 […]
The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms
Abstract Fine needle aspiration cytology (FNAC) plays an essential role in the evaluation of thyroid nodules especially for the category of follicular neoplasms (FN) representing 25 % of all thyroid cases including different neoplastic entities. Hence, one of the most promising areas is the application of molecular tests to FNAC. Among them, microRNAs (miRNA),identified as negative (post-transcriptional) gene expression regulators involved in tumor development, are likely to discriminate among FNs. Limited data explored the use of miRNAs on FNAC as well as their role in the malign...περισσότερα »
Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study
Abstract This multicentric study aimed to investigate the prevalence of the G protein-coupled receptor 101 (*GPR101)* p.E308D variant and aryl hydrocarbon receptor interacting protein (*AIP)* gene mutations in a representative cohort of Italian patients with acromegaly. 215 patients with GH-secreting pituitary adenomas, referred to 4 Italian referral centres for pituitary diseases, have been included. Three cases of gigantism were present. Five cases were classified as FIPA. All the patients have been screened for germline *AIP* gene mutations and *GPR101* gene p.E308D variant. He... περισσότερα »
Umfragestudie zur Behandlung des malignen Mediainfarkts an deutschen Kliniken
Zusammenfassung Hintergrund Der maligne Mediainfarkt (MMI) ist eine Erkrankung, für die neben der einzig nachgewiesenermaßen effektiven Therapie, der frühen Hemikraniektomie (HC), eine Vielzahl von intensivmedizinischen Therapien zur Verfügung steht. Wie mit der HC und den konservativen Therapien an deutschen Kliniken im Detail verfahren wird und welche Strukturen an den einzelnen Kliniken zur Behandlung des MMI vorhanden sind, ist nicht bekannt. Methoden Es wurden anonyme Fragebögen an 297 neurologische und 133 neurochirurgische Akutkliniken in Deutschland versandt. Ergebnisse ... περισσότερα »
Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
Article Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke. Here, the authors identify an early, MMP-independent BBB breakdown mechanism caused by rapid cytoskeletal rearrangements in endothelial cells, which could be inhibited by ADF. Nature Communications doi: 10.1038/ncomms10523 Authors: Yejie Shi, Lili Zhang, Hongjian Pu,… Continue reading Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
Evaluation of a weekly speech pathology/dietetic service model for providing supportive care intervention to head and neck cancer patients and their carers during (chemo)radiotherapy
Abstract Purpose Dysphagia is a common and debilitating side effect for head and neck cancer (HNC) patients undergoing radiotherapy (RT) with or without chemotherapy ([C]RT) and is associated with nutritional and emotional comorbidities. Emotional sequelae and distress are also known to affect carers of HNC patients. A weekly, joint speech pathology/dietetic (SP/DN) service-delivery model has… Continue reading Evaluation of a weekly speech pathology/dietetic service model for providing supportive care intervention to head and neck cancer patients and their carers during (chemo)radio... περισσότερα »
Generation of coherent spin-wave modes in yttrium iron garnet microdiscs by spin–orbit torque
Article Spin-orbit interactions allow for pure spin current to be injected into a ferromagnetic insulator from a current-carrying heavy metal, generating torque on the magnetization. Here, the authors evidence magnetic auto-oscillations driven by spin-orbit torque in thin film microdiscs of yttrium iron garnet. Nature Communications doi: 10.1038/ncomms10377 Authors: M. Collet, X. de Milly, O. d’Allivy… Continue reading Generation of coherent spin-wave modes in yttrium iron garnet microdiscs by spin–orbit torque
Poor chemotherapy-induced nausea and vomiting control in children receiving intermediate or high dose methotrexate
Abstract Purpose Chemotherapy emetogenicity is the most important known determinant of chemotherapy-induced vomiting (CIV) in children. However, direct evidence regarding the emetogenic potential of chemotherapeutic agents in children is limited. This study describes the prevalence of complete control of acute and delayed phase chemotherapy-induced nausea and vomiting (CINV) in children receiving methotrexate. The prevalence of… Continue reading Poor chemotherapy-induced nausea and vomiting control in children receiving intermediate or high dose methotrexate
Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment
Objective To calculate sustainable generic prices for 4 tyrosine kinase inhibitors (TKIs). Background TKIs have proven survival benefits in the treatment of several cancers, including chronic myeloid leukaemia, breast, liver, renal and lung cancer. However, current high prices are a barrier to treatment. Mass production of low-cost generic antiretrovirals has led to over 13 million… Continue reading Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment
Assessing herd immunity against rubella in Japan: a retrospective seroepidemiological analysis of age-dependent transmission dynamics
Objective We aimed to epidemiologically assess rubella herd immunity as a function of time, age and gender in Japan, with reference to the recent 2012–2014 rubella epidemic. Design This study is a retrospective seroepidemiological analysis. Main outcome measures The susceptible fraction of the population was examined as a function of age and time. The age… Continue reading Assessing herd immunity against rubella in Japan: a retrospective seroepidemiological analysis of age-dependent transmission dynamics
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
Article Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adar expression impairs normal waking in flies. Nature Communications doi: 10.1038/ncomms10512 Authors: J. E. Robinson, J. Paluch,… Continue reading ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model
Abstract Purpose Patients suffering from gastrointestinal mucositis often receive parenteral nutrition as nutritional support. However, the absence of enteral nutrition might not be beneficial for the intestine. We aimed to determine the feasibility of minimal enteral feeding (MEF) administration in a methotrexate (MTX)-induced mucositis rat model and thereby determine the effect of MEF on recovery.… Continue reading Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model
Independent predictors of major adverse cardiovascular events in emergency department patients who are hospitalised with a suspected infection: a retrospective cohort study
Objective Emergency department (ED) patients hospitalised with a suspected infection have an increased risk for major adverse cardiovascular events (MACE). This study aims to identify independent predictors of MACE after hospital admission which could be used for identification of high-risk patients who may benefit from preventive strategies. Setting Dutch tertiary care centre and urban hospital.… Continue reading Independent predictors of major adverse cardiovascular events in emergency department patients who are hospitalised with a suspected infection: a retrospective cohort study
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging
Abstract Purpose To analyze the features of gastrointestinal linitis plastica obtained by computed tomography (CT). Materials and methods We conducted a single-center, retrospective analysis of 45 cases of gastrointestinal tract linitis plastica collected over a 10-year period. “Linitis plastica” was defined based on histological characteristics. Primary and secondary linitis plastica were included. Two readers independently… Continue reading Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging
SAGES Assessment on the da Vinci ® Surgical System
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
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Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut INFECTIOUS DISEASE AND HOST RESPONSE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Helminth infections have been suggested to impair the development and outcome of Th1 responses to vaccines and intracellular microorganisms. However, there are limited data regarding the ability of intestinal nematodes to modulate Th1 responses at sites distal to the gut. In this study, we have investigated the effect of the intestinal nematode Heligmosomoides polygyrus bakeri […]
Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
With increasing numbers of patients with unresectable locoregionally advanced (LA) head and neck squamous cell carcinoma (HNSCC) receiving cetuximab/radiotherapy (RT), several guidelines on the early detection… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lUGbc5 via IFTTT
Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Over 20 % of ovarian cancer patients have preoperative thrombocytosis or hyperfibrinogenemia. We aimed to demonstrate the clinical and prognostic significance of thrombocytosis and hyperfibrinogenemia in high-… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lUGaFd via IFTTT
Erratum to: Menthol Inhibits the Proliferation and Motility of Prostate Cancer DU145 Cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
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Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Background: Although type I interferons (IFNs)—key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this […]
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Background: Alzheimer’s disease is associated with amyloid-beta (Aβ)-induced microglia activation. This pro-inflammatory response promotes neuronal damage, and therapies are sought to limit microglial activation. Screening efforts to develop new pharmacological inhibitors require a robust in vitro cell system. Current models lack significant responses to Aβ, and their use in examining age-related neurodegenerative diseases is questionable. […]
Erratum to: Association of environmental chemicals & estrogen metabolites in children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
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Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Abstract Objective The objective of this study was to investigate whether cancer-specific survival in rectal cancer patients is affected by patient-related factors, conditional on radiation treatment. Methods Three hundred fifty-nine invasive rectal cancer patients who consented and provided questionnaire data for a population-based case-control study of colorectal cancer in Metropolitan Detroit were included in this […]
Kathy Foltner, AuD, Receives Alumnus of the Year Award
Salus University named Kathy Foltner, AuD, the Salus University Audiology Alumna of the Year, an award given to an alumnus who has made constructive contributions to audiology and to the University's Osborne College of Audiology. Dr. Foltner is the founder and owner of AuDNet, Inc. and Foltner Consulting LLC, two national hearing health care purchasing organizations. She also teaches audiology practice management at Rush University Medical Center in Chicago. She will accept her award at the Salus University open house during AudiologyNOW! on Wednesday, April 13. *Pu... περισσότερα »
JAAA CEU Program.
Related Articles *JAAA CEU Program.* J Am Acad Audiol. 2016 Jan;27(1):64-5 Authors: PMID: 26809329 [PubMed - in process] from #Audiology via ola Kala on Inoreader http://ift.tt/1PTOop9 via IFTTT
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