Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV)
Tick-Borne Encephalitis sequelae at long-term follow-up: a self-reported case–control study: Background Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a major neurotropic infection throughout Europe and Asia, with a considerable risk of neurological sequelae. Our aim was to study the symptoms in patients with TBE in Western Gotaland between 1997 and 2012 in the acute phase and at follow-up after 2–15 years (median: 5.5 years). Methods The medical records of 96 patients with TBE were studied. Phone-based interviews were held with 92 patients and 58 controls, matche...περισσότερα »
Topiramate-induced paresthesia is more frequently reported by migraine than epileptic patients
Topiramate-induced paresthesia is more frequently reported by migraine than epileptic patients: AbstractTopiramate is an approved and effective drug in migraine prophylaxis. Paresthesia is the most commonly reported side effect. The primary objective of this study was to compare the frequency of topiramate-induced paresthesia in migraine headache to epileptic patients. Patients with migraine without aura and epilepsy were enrolled in this observational study. All cases were interviewed by telephone about their history of paresthesia. Confounding factors were controlled through log... περισσότερα »
Spatial attention and spatial working memory
Testing a dynamic-field account of interactions between spatial attention and spatial working memory: AbstractStudies examining the relationship between spatial attention and spatial working memory (SWM) have shown that discrimination responses are faster for targets appearing at locations that are being maintained in SWM, and that location memory is impaired when attention is withdrawn during the delay. These observations support the proposal that sustained attention is required for successful retention in SWM: If attention is withdrawn, memory representations are likely to fail, ... περισσότερα »
Schädel-Hirn-Trauma
Schädel-Hirn-Trauma: ZusammenfassungUnter jungen Erwachsenen gilt das Schädel-Hirn-Trauma (SHT) als die häufigste Ursache von langfristiger Behinderung und Tod, wodurch das SHT eine enorme gesundheitliche und sozialwirtschaftliche Belastung darstellt. Als Folge der Primärläsion entwickelt sich ein perifokales Hirnödem, das aufgrund des begrenzten intrakraniellen Raums einen Anstieg des intrakraniellen Drucks bewirkt. Dies hat eine Reduktion des zerebralen Perfusionsdrucks und somit der zerebralen Durchblutung zur Folge. Eine zerebrale Minderperfusion unterhalb der Ischämieschwelle ... περισσότερα »
Reversible Cerebral Vasoconstriction Syndrome Presenting With Visual Field Defects.
Reversible Cerebral Vasoconstriction Syndrome Presenting With Visual Field Defects.: A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clin...περισσότερα »
Reversible Cerebral Vasoconstriction Syndrome Presenting With Visual Field Defects.
Reversible Cerebral Vasoconstriction Syndrome Presenting With Visual Field Defects.: A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clin...περισσότερα »
Task-specific dystonia
Task-specific dystonia: pathophysiology and management: Task-specific dystonia is a form of isolated focal dystonia with the peculiarity of being displayed only during performance of a specific skilled motor task. This distinctive feature makes task-specific dystonia a particularly mysterious and fascinating neurological condition. In this review, we cover phenomenology and its increasingly broad-spectrum risk factors for the disease, critically review pathophysiological theories and evaluate current therapeutic options. We conclude by highlighting the unique features of task-speci... περισσότερα »
Microsaccades Are Coupled to Heartbeat
Microsaccades Are Coupled to Heartbeat: During visual fixation, the eye generates microsaccades and slower components of fixational eye movements that are part of the visual processing strategy in humans. Here, we show that ongoing heartbeat is coupled to temporal rate variations in the generation of microsaccades. Using coregistration of eye recording and ECG in humans, we tested the hypothesis that microsaccade onsets are coupled to the relative phase of the R-R intervals in heartbeats. We observed significantly more microsaccades during the early phase after the R peak in the EC...περισσότερα »
Functional Topography of Human Auditory Cortex
Functional Topography of Human Auditory Cortex: Functional and anatomical studies have clearly demonstrated that auditory cortex is populated by multiple subfields. However, functional characterization of those fields has been largely the domain of animal electrophysiology, limiting the extent to which human and animal research can inform each other. In this study, we used high-resolution functional magnetic resonance imaging to characterize human auditory cortical subfields using a variety of low-level acoustic features in the spectral and temporal domains. Specifically, we show t... περισσότερα »
Inner Ear: MEKK4 Signaling Regulates Sensory Cell Development and Function
MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear: Mechanosensory hair cells (HCs) residing in the inner ear are critical for hearing and balance. Precise coordination of proliferation, sensory specification, and differentiation during development is essential to ensure the correct patterning of HCs in the cochlear and vestibular epithelium. Recent studies have revealed that FGF20 signaling is vital for proper HC differentiation. However, the mechanisms by which FGF20 signaling promotes HC differentiation remain unknown. Here, we show that mito...περισσότερα »
Phase of Spontaneous Slow Oscillations during Sleep Influences Memory-Related Processing of Auditory Cues
Phase of Spontaneous Slow Oscillations during Sleep Influences Memory-Related Processing of Auditory Cues: Slow oscillations during slow-wave sleep (SWS) may facilitate memory consolidation by regulating interactions between hippocampal and cortical networks. Slow oscillations appear as high-amplitude, synchronized EEG activity, corresponding to upstates of neuronal depolarization and downstates of hyperpolarization. Memory reactivations occur spontaneously during SWS, and can also be induced by presenting learning-related cues associated with a prior learning episode during sleep.... περισσότερα »
Defensive strategies in humans
Stop or move: Defensive strategies in humans via Behavioural Brain Research [image: S01664328.gif] Publication date: 1 April 2016 *Source:*Behavioural Brain Research, Volume 302 Author(s): Aline F. Bastos, Andre S. Vieira, Jose M. Oliveira, Leticia Oliveira, Mirtes G. Pereira, Ivan Figueira, Fatima S. Erthal, Eliane Volchan Threatening cues and surrounding contexts trigger specific defensive response patterns. Potential threat evokes attentive immobility; attack evokes flight when escape is available and immobility when escape is blocked. Tonic immobility installs when threat is overw... περισσότερα »
Botulinum Toxin Type A for Neuropathic Pain
Botulinum Toxin Type A for Neuropathic Pain in Patients with Spinal Cord Injury: ABSTRACT *Objective*: To evaluate the analgesic effect of botulinum toxin type A (BTX-A) on patients with spinal cord injury-associated neuropathic pain. *Methods*: The effect of BTX-A on 40 patients with spinal cord injury-associated neuropathic pain was investigated using a randomized, double-blind, placebo-controlled design. A one-time subcutaneous BTX-A (200 units) injection was administered to the painful area. Visual analogue scale scores (0-100 mm), the Korean-version of the short-form McGill Pai... περισσότερα »
Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival
Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival: Background Malignant brain tumors have a dismal prognosis, with residual tumor remaining after surgery necessitating adjuvant chemoradiotherapy. The blood-brain barrier hinders many chemotherapeutic agents, resulting in modest treatment efficacy. We previously demonstrated that targeted natural killer (NK)-92 cells could be delivered to desired regions of the brain using MRI-guided focused ultrasound and Definity microbubbles. Targeted NK-92 cells have advantages over m...περισσότερα »
Skull base chordoma and chondrosarcoma
Is there a role for conventional MRI and MR diffusion-weighted imaging for distinction of skull base chordoma and chondrosarcoma?: Background Chordoma and chondrosarcoma are locally invasive skull base tumors with similar clinical symptoms and anatomic imaging features as reported in the literature. Purpose To determine differentiation of chordoma and chondrosarcoma of the skull base with conventional magnetic resonance imaging (cMRI) and diffusion-weighted MR imaging (DWI) in comparison to histopathological diagnosis. Material and Methods This retrospective study comprised 96 (c...περισσότερα »
Head and neck venous and lymphatic malformations
Quantitative volumetric analysis of head and neck venous and lymphatic malformations to assess response to percutaneous sclerotherapy: Background Venous and lymphatic malformations of the head and neck can be successfully treated with percutaneous sclerotherapy. Purpose To examine the utility of three-dimensional volumetric analysis to assess these lesions and their response to therapy. Material and Methods Prospectively maintained procedure records were retrospectively reviewed to identify all patients with vascular malformations who underwent percutaneous sclerotherapy. Clinical... περισσότερα »
Modern humans and Neandertals
Brain, calvarium, cladistics: A new approach to an old question, who are modern humans and Neandertals? via Journal of Human Evolution Publication date: March 2016 *Source:*Journal of Human Evolution, Volume 92 Author(s): Aurélien Mounier, Antoine Balzeau, Miguel Caparros, Dominique Grimaud-Hervé The evolutionary history of the genus Homo is the focus of major research efforts in palaeoanthropology. However, the use of palaeoneurology to infer phylogenies of our genus is rare. Here we use cladistics to test the importance of the brain in differentiating and defining Neandertals and mo...περισσότερα »
Crisponi/CISS1 syndrome: Major feeding difficulties, camptodactyly, and anhidrosis in early childhood
Crisponi/CISS1 syndrome: A case series: Crisponi/CISS1 syndrome (MIM#272430) is a rare autosomal recessive disease characterized by major feeding difficulties, camptodactyly, and anhidrosis in early childhood; and the subsequent development of paradoxical cold-induced sweating and scoliosis later in life. The syndrome is caused by biallelic mutations in *CRLF1* or, much less commonly, *CLCF1*. Although genotype/phenotype correlation has been elusive, it has been suggested that the level of the mutant protein may correlate with the phenotypic severity. However, we show in this serie...περισσότερα »
Reliability and day-to-day variability of peak fat oxidation during treadmill ergometry.
*Reliability and day-to-day variability of peak fat oxidation during treadmill ergometry.* J Int Soc Sports Nutr. 2016;13:4 Authors: De Souza Silveira R, Carlsohn A, Langen G, Mayer F, Scharhag-Rosenberger F Abstract BACKGROUND: Exercising at intensities where fat oxidation rates are high has been shown to induce metabolic benefits in recreational and health-oriented sportsmen. The exercise intensity (Fatpeak) eliciting peak fat oxidation rates is therefore of particular interest when aiming to prescribe exercise for the purpose of fat oxidation and related metabolic effects. A... περισσότερα »
Influence of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus on Gut Microbiota in the First Month of Life
Influence of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus on Gut Microbiota in the First Month of Life: [image: image]Objectives: The effect of intrapartum antibiotic prophylaxis (IAP) for group B Streptococcus (GBS) on bacterial colonization of the infant's gut has not been investigated extensively. We aimed to evaluate the effect of IAP on gut microbiota in healthy term infants, also exploring the influence of type of feeding. Methods: Healthy term infants, whose mothers had been screened for GBS in late gestation, were divided into 2 groups: infants born to GBS-pos... περισσότερα »
Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue
During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. Apicobasal polarity is critical to the specialized functions of these epithelia. Indeed, a common feature of epithelial dysfunction is the loss of pola... περισσότερα »
Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?
Th17/IL-17 plays an important role in host defense and hyperimmune responses against pathogenic bacteria accompanied by the recruitment of neutrophils. Th17-associated immune response is also involved in the pathogenesis of asthma, which is known as a noninfectious allergic airway disease and has been shown to be heterogeneous. Th17-associated inflammation usually contributes to the neutrophilic phenotype, which is often characterized by greater severity, airflow obstruction, and steroid resistance. Concurrently, advanced culture-independent molecular techniques have increased our...περισσότερα »
Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion
Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion: [image: image]Objectives: The relation between tooth erosion (TE) and gastroesophageal reflux in children has not been clearly established, and there are no studies to determine the relation with refluxate height, nonacid reflux, and erosions. The aim of this study was to determine the relation between TE and acid and nonacid gastroesophageal refluxes measured using combined pH and multichannel intraluminal impedance (pH-MII). Methods: We conducted a prospective cohort study of children presenting for pH-MII test...περισσότερα »
Perivascular Epithelioid Cell Tumour with Intraorbital Location
Perivascular Epithelioid Cell Tumour with Intraorbital Location: Report of a Case and Review of the Literature: The Perivascular Epithelioid Cell tumours (PEComas) are rare mesenchymal neoplasms recognized as entity by the World Health Organization. The tumour cells have an uncertain origin and are characterized by distinctive histological and immunohistochemical features. We report a case of PEComa occurring as intraorbital lesion in a 47-year-old man. We found only two other cases described in the literature and we considered all three cases together in order of histology, immunoh...περισσότερα »
The pterygopalatine recess of the superior nasal meatus
The pterygopalatine recess of the superior nasal meatus: AbstractThe pneumatizations surrounding the pterygopalatine fossa (PPF) and closely related to the sphenopalatine foramen are anatomically variable. During the assessment of a cone beam computed tomography of a 64-year-old male patient, we found bilaterally a previously unreported anatomic variant. This was represented by a lateral or pterygopalatine recess (PPR) of the superior nasal meatus which extended in the anterior wall of the PPF and protruded within the maxillary sinus to determine a maxillary bulla. The PPR was ante...περισσότερα »
Collagen Conduit with Duloxetine and/or Pregabalin in the Management of Partial Peripheral Nerve Injury
The Role of via Oral and Maxillofacial Surgery *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Junad Khan, Hamed Alghamdi, Muhammad Moin Anwer, Eli Eliav, Vincent Ziccardi PurposeThe objective of this study was to investigate the analgesic effect of collagen conduit (Neuragen®, Integra Lifescince Corp, Plainsboro, NJ) with duloxetine (Cymbalta ®, Lilly, Indianopolis, IN) and/or pregabalin (Lyrica®, Pfizer, NY) on pain induced by partial sciatic nerve transection in a rat model.Material and MethodsAdult male Sprague-Dawley rats were divided into 5 groups (n=10/group): ... περισσότερα »
"Zhonghua Yi Xue Za Zhi"[jour]; +161 new citations
161 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"Zhonghua Yi Xue Za Zhi"[jour]* These pubmed results were generated on 2016/01/28 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1SlgQVp via IFTTT
upper respiratory tract infection; +23 new citations
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/01/28 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1nq7jkf via IFTTT
High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma.
*High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma.* Future Oncol. 2016 Feb;12(3):323-331 Authors: Salem N, Kamal I, Al-Maghrabi J, Abuzenadah A, Peer-Zada AA, Qari Y, Al-Ahwal M, Al-Qahtani M, Buhmeida A Abstract AIM: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) and determine its prognostic potential. PATIENTS & METHODS: CRC samples of 127 patients were studied. Protein expressions of MMP-2, -7 and -9 were analyzed by immunohistochemistr... περισσότερα »
Gene-expression profiling of localized prostate cancer: still miles to go before we sleep.
*Gene-expression profiling of localized prostate cancer: still miles to go before we sleep.* Future Oncol. 2016 Feb;12(3):273-276 Authors: Garzotto M, Kopp RP PMID: 26814711 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1KcFB54 via IFTTT
Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004.
*Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004.* Pediatr Blood Cancer. 2016 Jan 27; Authors: Hassler A, Bochennek K, Gilfert J, Perner C, Schöning S, Creutzig U, Reinhardt D, Lehrnbecher T Abstract BACKGROUND: Children with acute myeloid leukemia (AML) and Down syndrome have high survival rates with intensity-reduced chemotherapeutic regimens, although the optimal balance between dose intensity and treatment toxicity has not been determined. We, therefore, characterized infectious co... περισσότερα »
Core principles of sexual health treatments in cancer for men.
*Core principles of sexual health treatments in cancer for men.* Curr Opin Support Palliat Care. 2016 Mar;10(1):38-43 Authors: Matthew A Abstract PURPOSE OF REVIEW: The considerable prevalence of sexual health problems in men after cancer treatment coupled with the severity of impact and challenges to successful intervention make sexual dysfunction one of the most substantial health-related quality of life burdens in all of cancer survivorship. Surgeries, radiation therapies, and nontreatment (e.g., active surveillance) variously result in physical disfigurement, pain, and disru... περισσότερα »
Premalignancy in Prostate Cancer: Rethinking What we Know.
*Premalignancy in Prostate Cancer: Rethinking What we Know.* Cancer Prev Res (Phila). 2016 Jan 26; Authors: De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG Abstract High-grade prostatic intra-epithelial neoplasia (PIN) has been accepted as the main precursor lesion to invasive adenocarcinoma of the prostate, and this is likely to be the case. However, in an unknown number of cases, lesions fulfilling the diagnostic criteria for high-grade PIN may actually represent intra-acinar or intra-ductal spread of invasive carcinoma. Intriguingly, this possibility would not... περισσότερα »
Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma.
*Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma.* Neurosurgery. 2016 Jan 19; Authors: Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, OʼRourke DM, Davatzikos C Abstract BACKGROUND: Glioblastoma is an aggressive and highly infiltrative brain cancer. Standard surgical resection is guided by enhancement on postcontrast T1-weighted (T1) magnetic resonance imaging, which is insufficient for delineating surrounding infiltrating tumor. OBJECTIVE...περισσότερα »
Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.
*Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.* Genome Biol. 2016;17(1):10 Authors: Lallous N, Volik SV, Awrey S, Leblanc E, Tse R, Murillo J, Singh K, Azad AA, Wyatt AW, LeBihan S, Chi KN, Gleave ME, Rennie PS, Collins CC, Cherkasov A Abstract BACKGROUND: The androgen receptor (AR) is a pivotal drug target for the treatment of prostate cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR antagonists, such as hydroxyflutamide, b... περισσότερα »
Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.
*Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.* Nat Commun. 2016;7:10499 Authors: Wang C, Gu Y, Zhang K, Xie K, Zhu M, Dai N, Jiang Y, Guo X, Liu M, Dai J, Wu L, Jin G, Ma H, Jiang T, Yin R, Xia Y, Liu L, Wang S, Shen B, Huo R, Wang Q, Xu L, Yang L, Huang X, Shen H, Sha J, Hu Z Abstract Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver genes in cancer. In this study, we integrate transcriptomi... περισσότερα »
Nausea and vomiting induced by gastrointestinal radiation therapy: current status and future directions.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Nausea and vomiting induced by gastrointestinal radiation therapy: current status and future directions.* Curr Opin Support Palliat Care. 2015 Jun;9(2):182-8 Authors: Dennis K, Poon M, Chow E Abstract PURPOSE OF REVIEW: Radiation therapy-induced nausea and vomiting (RINV) are common and troublesome symptoms among patients receiving radiation therapy for gastrointestinal cancers. Their impact on function, quality of life and, ultimately, cancer control warrant a review of their incidence, underlying mechanisms, tr...περισσότερα »
Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action.* Curr Opin Support Palliat Care. 2015 Jun;9(2):157-62 Authors: Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ Abstract PURPOSE OF REVIEW: There is currently an unmet need for agents that can prevent the gastrointestinal toxicity (mucositis and enteritis) associated with chemotherapy and radiation therapy of abdominal and pelvic cancers. Herein we provide an overview of how manipulation of the gut microb... περισσότερα »
Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein.* Cancer Gene Ther. 2015 Mar;22(4):215-21 Authors: Lears KA, Parry JJ, Andrews R, Nguyen K, Wadas TJ, Rogers BE Abstract Suicide gene therapy is a process by which cells are administered a gene that encodes a protein capable of converting a nontoxic prodrug into an active toxin. Cytosine deaminase (CD) has been widely investigated as a means of suicide gene therapy owing to the en... περισσότερα »
Frontiers in regenerative medical materials: Comments from the participants of the 2014 China-Korea Symposium on Biomimetic and Regenerative Medical Materials.
*Frontiers in regenerative medical materials: Comments from the participants of the 2014 China-Korea Symposium on Biomimetic and Regenerative Medical Materials.* Regen Biomater. 2015 Mar;2(1):71-76 Authors: Ma J, Noh I, Lee IS, Zhang S PMID: 26816632 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1lWeiAs via IFTTT
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
*Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.* Ann Clin Transl Neurol. 2015 Nov;2(11):987-1001 Authors: Damme M, Stroobants S, Lüdemann M, Rothaug M, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D'Hooge R, Saftig P, Blanz J Abstract OBJECTIVE: The lysosomal storage disease alpha-mannosidosis is caused by the deficiency of the lysosomal acid hydrolase alpha-mannosidase (LAMAN) leading to lysosomal accumulation of neutral mannose-linked oligosaccharides throughout the body, including the brain. Clinical findings in alpha-... περισσότερα »
Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer.
*Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer.* Clin Neurol Neurosurg. 2016 Jan 14;142:72-80 Authors: Enders F, Geisenberger C, Jungk C, Bermejo JL, Warta R, von Deimling A, Herold-Mende C, Unterberg A Abstract OBJECTIVE: Brain metastases (BMs) are the most common malignant brain tumors in adults. Despite multimodal treatment options such as microsurgery, radiotherapy and chemotherapy, prognosis still remains very poor. Non-small cell lung cancer (NSCLC) constitutes the most common source of brain metastases. In...περισσότερα »
Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
*Active medulloblastoma enhancers reveal subgroup-specific cellular origins.* Nature. 2016 Jan 27; Authors: Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, Segura-Wang M, Waszak SM, Jones DT, Kool M, Hovestadt V, Buchhalter I, Sieber L, Johann P, Chavez L, Gröschel S, Ryzhova M, Korshunov A, Chen W, Chizhikov VV, Millen KJ, Amstislavskiy V, Lehrach H, Yaspo ML, Eils R, Lichter P, Korbel JO, Pfister SM, Bradner JE, Northcott PA Abstract Medulloblastoma is a highly malignant paediatr...περισσότερα »
How to evaluate sexual health in cancer patients: development of the EORTC sexual health questionnaire for cancer patients.
*How to evaluate sexual health in cancer patients: development of the EORTC sexual health questionnaire for cancer patients.* Transl Androl Urol. 2015 Apr;4(2):95-102 Authors: Nagele E, Den Oudsten B, Greimel E, EORTC Quality of Life Group Abstract BACKGROUND: The aim of the study is to describe the development of a comprehensive European Organisation for Research and Treatment of Cancer (EORTC) questionnaire to assess sexual health of female and male cancer patients and for cancer survivors. METHODS: According to the EORTC guidelines, the development of an EORTC sexual health qu... περισσότερα »
Attitude and practice of brachytherapy in India: a study based on the survey amongst attendees of Annual Meeting of Indian Brachytherapy Society.
*Attitude and practice of brachytherapy in India: a study based on the survey amongst attendees of Annual Meeting of Indian Brachytherapy Society.* J Contemp Brachytherapy. 2015 Dec;7(6):462-468 Authors: Gandhi AK, Sharma DN, Julka PK, Rath GK Abstract PURPOSE: We performed a survey amongst attendees of the 4(th) Annual Meeting of Indian Brachytherapy Society to study the patterns of brachytherapy practice and attitude towards brachytherapy use. MATERIAL AND METHODS: A 19-point questionnaire was designed and e-mailed to the attendees immediately after the conference. Descriptive a... περισσότερα »
Reliability and day-to-day variability of peak fat oxidation during treadmill ergometry.
*Reliability and day-to-day variability of peak fat oxidation during treadmill ergometry.* J Int Soc Sports Nutr. 2016;13:4 Authors: De Souza Silveira R, Carlsohn A, Langen G, Mayer F, Scharhag-Rosenberger F Abstract BACKGROUND: Exercising at intensities where fat oxidation rates are high has been shown to induce metabolic benefits in recreational and health-oriented sportsmen. The exercise intensity (Fatpeak) eliciting peak fat oxidation rates is therefore of particular interest when aiming to prescribe exercise for the purpose of fat oxidation and related metabolic effects. A... περισσότερα »
High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma.
*High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma.* Future Oncol. 2016 Feb;12(3):323-331 Authors: Salem N, Kamal I, Al-Maghrabi J, Abuzenadah A, Peer-Zada AA, Qari Y, Al-Ahwal M, Al-Qahtani M, Buhmeida A Abstract AIM: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) and determine its prognostic potential. PATIENTS & METHODS: CRC samples of 127 patients were studied. Protein expressions of MMP-2, -7 and -9 were analyzed by immunohistochemistr... περισσότερα »
Gene-expression profiling of localized prostate cancer: still miles to go before we sleep.
*Gene-expression profiling of localized prostate cancer: still miles to go before we sleep.* Future Oncol. 2016 Feb;12(3):273-276 Authors: Garzotto M, Kopp RP PMID: 26814711 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1KcFB54 via IFTTT
Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004.
*Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML-BFM 2004.* Pediatr Blood Cancer. 2016 Jan 27; Authors: Hassler A, Bochennek K, Gilfert J, Perner C, Schöning S, Creutzig U, Reinhardt D, Lehrnbecher T Abstract BACKGROUND: Children with acute myeloid leukemia (AML) and Down syndrome have high survival rates with intensity-reduced chemotherapeutic regimens, although the optimal balance between dose intensity and treatment toxicity has not been determined. We, therefore, characterized infectious co... περισσότερα »
Core principles of sexual health treatments in cancer for men.
*Core principles of sexual health treatments in cancer for men.* Curr Opin Support Palliat Care. 2016 Mar;10(1):38-43 Authors: Matthew A Abstract PURPOSE OF REVIEW: The considerable prevalence of sexual health problems in men after cancer treatment coupled with the severity of impact and challenges to successful intervention make sexual dysfunction one of the most substantial health-related quality of life burdens in all of cancer survivorship. Surgeries, radiation therapies, and nontreatment (e.g., active surveillance) variously result in physical disfigurement, pain, and disru... περισσότερα »
Premalignancy in Prostate Cancer: Rethinking What we Know.
*Premalignancy in Prostate Cancer: Rethinking What we Know.* Cancer Prev Res (Phila). 2016 Jan 26; Authors: De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG Abstract High-grade prostatic intra-epithelial neoplasia (PIN) has been accepted as the main precursor lesion to invasive adenocarcinoma of the prostate, and this is likely to be the case. However, in an unknown number of cases, lesions fulfilling the diagnostic criteria for high-grade PIN may actually represent intra-acinar or intra-ductal spread of invasive carcinoma. Intriguingly, this possibility would not... περισσότερα »
Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma.
*Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma.* Neurosurgery. 2016 Jan 19; Authors: Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, OʼRourke DM, Davatzikos C Abstract BACKGROUND: Glioblastoma is an aggressive and highly infiltrative brain cancer. Standard surgical resection is guided by enhancement on postcontrast T1-weighted (T1) magnetic resonance imaging, which is insufficient for delineating surrounding infiltrating tumor. OBJECTIVE...περισσότερα »
Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.
*Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.* Genome Biol. 2016;17(1):10 Authors: Lallous N, Volik SV, Awrey S, Leblanc E, Tse R, Murillo J, Singh K, Azad AA, Wyatt AW, LeBihan S, Chi KN, Gleave ME, Rennie PS, Collins CC, Cherkasov A Abstract BACKGROUND: The androgen receptor (AR) is a pivotal drug target for the treatment of prostate cancer, including its lethal castration-resistant (CRPC) form. All current non-steroidal AR antagonists, such as hydroxyflutamide, b... περισσότερα »
Preventing Hereditary Angioedema Attacks : Τρανεξαμικό οξύ Tranexamic Acid
*Tranex ® è ένα φάρμακο που βασίζεται Τρανεξαμικό οξύ.* *Θεραπεία Ομάδα: Αντιαιμορραγικά - αντιϊνωδολυτική.* *ΑΙΜΟΡΡΑΓΊΕΣ. ΠΙÙ ΑΚΡΙΒΏΣ ΤΡΑΝΕΞΑΜΙΚΌ ΟΞΎ ΜΠΟΡΕΊ ΝΑÒ ΕΊΝΑΙ ΧΡΉΣΙΜΕΣ:* - *ΣΤΗΝ ΙΑΤΡΙΚΉ ΓΙΑ ΤΗΝ ΠΡΌΛΗΨΗ ΚΑΙ ΤΗ ΘΕΡΑΠΕΊΑ ΤΗΣ ΓΑΣΤΡΕΝΤΕΡΙΚΉΣ ΑΙΜΟΡΡΑΓΊΑΣ, ΑΙΜΟΡΡΑΓΙΚΉ ΣΎΝΔΡΟΜΑ ΣΕ ΑΣΘΕΝΕΊΣ ΜΕ ΛΕΥΧΑΙΜΊΑ, ΑΙΜΟΦΙΛΊΑ, ΜΟΒ Ή ΥΠΟΒΆΛΛΟΝΤΑΙ ΣΕ ΘΡΟΜΒΟΛΥΤΙΚΉ ΘΕΡΑΠΕΊΑ?* - *ΣΕ ΧΕΙΡΟΥΡΓΙΚΉ ΕΠΈΜΒΑΣΗ ΓΙΑ ΤΗΝ ΠΡΌΛΗΨΗ ΤΗΣ ΑΙΜΟΡΡΑΓΊΑΣ ΚΑΤΆ ΤΗ ΔΙΆΡΚΕΙΑ ΤΗΣ ΧΕΙΡΟΥΡΓΙΚΉΣ ΕΠΈΜΒΑΣΗΣ ΕΠΕΚΤΆΘΗΚΕ?* - *ΣΕ ΜΑΙΕΥΤΙΚΉ ΣΤΗΝ ΠΡΌΛΗΨΗ Ή ΠΕΡΙΟΡΙΣΜΌ ΤΗΣ ΑΙΜΟΡΡΑΓΊΑΣ ΜΕΤΆ ΤΟΝ ΤΟΚΕΤΌ, ΠΟΥ ΛΑΜΒΆΝΕΤΑ... περισσότερα »
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Molecular profiling has uncovered genetic subtypes of glioblastoma (GBM), including tumors with IDH1 mutations that confer increase survival and improved response to standard-of-care therapies. By mapping the g... from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1PCTZzy via IFTTT
Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms
Genomic techniques in recent years have allowed the identification of many mutated genes important in the pathogenesis of acute myeloid leukemia (AML). Together with cytogenetic aberrations, these gene mutatio... from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1SleHJA via IFTTT
SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males
Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study... from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1PCTZjf via IFTTT
IgG4-related inflammatory pseudotumor of the renal pelvis involving renal parenchyma, mimicking malignancy
IgG4-related disease is a recently recognized systemic disease characterized by storiform fibrosis with infiltration of IgG4-positive plasma cells. In rare incidences, IgG4-related renal disease can present as... from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1PCTXrB via IFTTT
Hypothyroidism among SLE patients: Case–control study
Publication date: Available online 28 January 2016 *Source:*Autoimmunity Reviews Author(s): Abdulla Watad, Naim Mahroum, Aaron Whitby, Smadar Gertel, Doron Comaneshter, Arnon D. Cohen, Howard Amital BackgroundThe prevalence of hypothyroidism in SLE patients varies considerably and early reports were mainly based on small cohorts.ObjectivesTo investigate the association between SLE and hypothyroidism.MethodsPatients with SLE were compared with age and sex-matched controls regarding the proportion of hypothyroidism in a case–control study. Chi-square and t-tests were used for univaria... περισσότερα »
Ilio-psoas hematoma in the intensive care unit: a multicentric study
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Clinical features and outcomes of patients with spontaneous ilio-psoas hematoma (IPH) in intensive care units (ICUs) are poorly documented. The objectives of this study were to determine epidemiological, clin… from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ORyn5e via IFTTT
Treatment intensity, age and outcome in medical ICU patients: results of a French administrative database
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Intensive care unit (ICU) patients are aging, and older age has been associated with higher mortality in ICU. As previous studies have reported that older age was also associated with less intensive treatment,… from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ORymOI via IFTTT
Elevated C-reactive protein levels at ICU discharge as a predictor of ICU outcome: a retrospective cohort study
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Before discharging a patient from the ICU, an adequate patient evaluation is needed to detect individuals as high risk for unfavorable outcome. A pro- or anti-inflammatory status is a potential risk factor fo… from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ORymhS via IFTTT
Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Breakdown of renal endothelial, tubular and glomerular matrix collagen plays a major role in acute kidney injury (AKI) development. Such collagen breakdown releases endostatin into the circulation. The aim of … from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ORymyc via IFTTT
Changes in cardiac arrest patients’ temperature management after the 2013 “TTM” trial: results from an international survey
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Therapeutic hypothermia (TH between 32 and 34 °C) was recommended until recently in unconscious successfully resuscitated cardiac arrest (CA) patients, especially after initial shockable rhythm. A randomized c… from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/207DiaT via IFTTT
Preventing Hereditary Angioedema Attacks
Treating angioedema *Medication is the main treatment for angioedema, although many cases get better after a few days without treatment.* *Allergic angioedema and idiopathic angioedema are usually treated in the same way, using a combination of antihistamines and corticosteroids to help relieve the swelling.* *Drug-induced angioedema can usually be treated by using an alternative medication to the one causing your symptoms.* *If you also had symptoms of anaphylaxis during an episode of angioedema, you will probably be given an adrenaline auto-injector pen in case your symptoms return... περισσότερα »
Erratum to: Effect of mold type, diameter, and uncured composite removal method on depth of cure
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
from OroFacial via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ROQigM via IFTTT
Influence of ultrasonic and sonic activation of epoxy-amine resin-based sealer on penetration of sealer into lateral canals
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Objectives The aim of this study was to evaluate the efficacy of sonic and ultrasonic activation of epoxy-amine resin-based root canal sealer (2Seal; VDW GmbH, München, Germany) on penetration of the sealer into lateral canals compared to non-activated filling. Materials and methods Thirty-six single-rooted human anterior teeth were decoronated and prepared, using the ProTaper […]
A micro-computed tomography assessment of the efficacy of rotary and reciprocating techniques for filling material removal in root canal retreatment
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Objectives The aim of this study was to compare the efficacy of rotary and reciprocating techniques for removing filling material from root canals, using micro-computed tomography (micro-CT) imaging. Materials and methods The distal root canals of 42 human mandibular molars were instrumented with hand files up to size 40 according to a step-down technique […]
Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Objectives Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and […]
Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine.
*Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine.* Otolaryngol Head Neck Surg. 2016 Jan 26; Authors: Capasso R, Rosa T, Tsou DY, Nekhendzy V, Drover D, Collins J, Zaghi S, Camacho M Abstract OBJECTIVE: To compare VOTE classification findings (velum, oropharyngeal-lateral walls, tongue base, and epiglottis) for drug-induced sleep endoscopy (DISE) among patients with obstructive sleep apnea (OSA) using 2 sedation protocols. STUDY DESIGN: Case series with chart review. SETTING: Single tertiary institution. SUBJECTS: ...περισσότερα »
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty.
*Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty.* Otolaryngol Head Neck Surg. 2016 Jan 26; Authors: Mahboubi H, Mohraz A, Verma SP Abstract OBJECTIVE: To compare the viscoelastic properties of calcium hydroxyapatite (CaHA) to carboxymethylcellulose (CMC) injectables used for injection laryngoplasty and determine if they are affected by heating and shearing. STUDY DESIGN: Experimental. SETTING: University laboratory. SUBJECTS AND METHODS: Vocal fold injection laryngoplasty with CaHA is oftentimes challengi... περισσότερα »
Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine.
*Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine.* Otolaryngol Head Neck Surg. 2016 Jan 26; Authors: Capasso R, Rosa T, Tsou DY, Nekhendzy V, Drover D, Collins J, Zaghi S, Camacho M Abstract OBJECTIVE: To compare VOTE classification findings (velum, oropharyngeal-lateral walls, tongue base, and epiglottis) for drug-induced sleep endoscopy (DISE) among patients with obstructive sleep apnea (OSA) using 2 sedation protocols. STUDY DESIGN: Case series with chart review. SETTING: Single tertiary institution. SUBJECTS: ...περισσότερα »
A Not So Lucky Penny.
*A Not So Lucky Penny.* Otolaryngol Head Neck Surg. 2016 Jan 26; Authors: Hiebert JC, Baranano CF PMID: 26814207 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1nAotfK via IFTTT
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Molecular profiling has uncovered genetic subtypes of glioblastoma (GBM), including tumors with IDH1 mutations that confer increase survival and improved response to standard-of-care therapies. By mapping the g... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1PCTZzy via IFTTT
Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Genomic techniques in recent years have allowed the identification of many mutated genes important in the pathogenesis of acute myeloid leukemia (AML). Together with cytogenetic aberrations, these gene mutatio... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1SleHJA via IFTTT
SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1PCTZjf via IFTTT
IgG4-related inflammatory pseudotumor of the renal pelvis involving renal parenchyma, mimicking malignancy
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
IgG4-related disease is a recently recognized systemic disease characterized by storiform fibrosis with infiltration of IgG4-positive plasma cells. In rare incidences, IgG4-related renal disease can present as... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1PCTXrB via IFTTT
Gastric outlet obstruction secondary to solid-pseudopapillary neoplasm of the pancreas in an eight year old child. Report of a case
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Solid pseudopapillary neoplasm is a rare cystic tumor of the exocrine pancreas. Abdominal pain or discomfort is the most common symptom, usually in young females. from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1SleHt2 via IFTTT
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT via Hearing Research Publication date: Available online 28 January 2016 Source:Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of… Continue reading 3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Erratum to: Differentiation of Human Endometrial Stem Cells into Schwann Cells in Fibrin Hydrogel as 3D Culture
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ORvtxq via IFTTT
Most elderly breast cancer patients in the US who could skip radiation still receive it https://t.co/W0ULzNjkHo
Most elderly breast cancer patients in the US who could skip radiation still receive it https://t.co/W0ULzNjkHo from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/692685087352197120 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SLVnXk via IFTTT
Elevated Serum Brain-Derived Neurotrophic Factor (BDNF) but not BDNF Gene Val66Met Polymorphism Is Associated with Autism Spectrum Disorders
Abstract The aim of our study was to illuminate the potential role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). We measured the circulating levels of BDNF in serum and BDNF gene (Val66Met) polymorphisms, in which two indicators were then compared between ASD and normal controls. A total of 82 drug-naïve ASD children… Continue reading Elevated Serum Brain-Derived Neurotrophic Factor (BDNF) but not BDNF Gene Val66Met Polymorphism Is Associated with Autism Spectrum Disorders
RT @sharp_lena : Are you a PhD-student in cancer nursing? Apply for EONS 1st Workshop in Scotland, May 2016. More info at https://t.co/Zuv…
RT @sharp_lena : Are you a PhD-student in cancer nursing? Apply for EONS 1st Workshop in Scotland, May 2016. More info at https://t.co/Zuv… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/692672792974770176 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KH8ssZ… Continue reading RT @sharp_lena : Are you a PhD-student in cancer nursing? Apply for EONS 1st... περισσότερα »
Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity
Abstract Attention deficit hyperactivity disorder (ADHD) is a child developmental and behavioral disorder which seriously hinders their education and development. To investigate the key regulators in the prefrontal cortex (PFC), the major affected areas of ADHD, microRNA (miR)-138,138*, 34c*, 296, and 494, were noted for their significant downregulation in ADHD model rats spontaneously hypertensive rats… Continue reading Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity
Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis
Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ORvxxi via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nApBjA via IFTTT
Artesunate Protected Blood–Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats
Abstract Blood–brain barrier preservation plays an important role in attenuating vasogenic brain edema after subarachnoid hemorrhage (SAH). This study was designed to investigate the protective effect and mechanism of artesunate, a traditional anti-malaria drug, on blood–brain barrier after SAH. Three hundred and seventy-seven (377) male Sprague–Dawley rats were subjected to endovascular perforation model for SAH.… Continue reading Artesunate Protected Blood–Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats
Integrative pathway genomics of lung function and airflow obstruction
Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loci, but explain only a modest portion of the phenotypic variability. We postulated that integrating pathway-based methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire of… Continue reading Integrative pathway genomics of lung function and airflow obstruction
Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms
Publication date: 2 March 2016 Source:Journal of Ethnopharmacology, Volume 180 Author(s): Min Wu, Tingting Li, Lilan Chen, Sugang Peng, Wei Liao, Ruolan Bai, Xue Zhao, Hong Yang, Chunhui Wu, Hongjuan Zeng, Yiyao Liu Ethnopharmacological relevanceAngelicae dahurica (Hoffm.) Benth. & Hook.f.ex Franch. & Sav combined with Pueraria and Gastrodia elata Bl. combined with Inula japonica Thunb.… Continue reading Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms
The pterygopalatine recess of the superior nasal meatus
The pterygopalatine recess of the superior nasal meatus: AbstractThe pneumatizations surrounding the pterygopalatine fossa (PPF) and closely related to the sphenopalatine foramen are anatomically variable. During the assessment of a cone beam computed tomography of a 64-year-old male patient, we found bilaterally a previously unreported anatomic variant. This was represented by a lateral or pterygopalatine recess (PPR) of the superior nasal meatus which extended in the anterior wall of the PPF and protruded within the maxillary sinus to determine a maxillary bulla. The PPR was ante...περισσότερα »
Sjogren's syndrome and multiple sclerosis
: Two sides of the same coin? via Autoimmunity Reviews Publication date: Available online 28 January 2016 *Source:*Autoimmunity Reviews Author(s): Gianni Masi, Pasquale Annunziata
Hypothyroidism among SLE patients
: Case–control study via Autoimmunity Reviews Publication date: Available online 28 January 2016 *Source:*Autoimmunity Reviews Author(s): Abdulla Watad, Naim Mahroum, Aaron Whitby, Smadar Gertel, Doron Comaneshter, Arnon D. Cohen, Howard Amital BackgroundThe prevalence of hypothyroidism in SLE patients varies considerably and early reports were mainly based on small cohorts.ObjectivesTo investigate the association between SLE and hypothyroidism.MethodsPatients with SLE were compared with age and sex-matched controls regarding the proportion of hypothyroidism in a case–control study. C... περισσότερα »
The anterolateral thigh flap for functional reconstruction after hemiglossectomy
Individual design of the anterolateral thigh flap for functional reconstruction after hemiglossectomy: experience with 238 patients via Oral and Maxillofacial Surgery Publication date: Available online 27 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): L. Wang, K. Liu, Z. Shao, Z.-J. Shang The aim of this study was to evaluate tongue function in patients with oral cancer treated surgically and reconstructed with anterolateral thigh free flaps (ALTFs). Patients (N=238) underwent primary reconstruction after hemiglossectomy between September 2012 a... περισσότερα »
Gnathodiaphyseal dysplasia
: report of a family with a novel mutation of the ANO5 gene via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 28 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Hannah A. Duong, Karen T. Le, Albert L. Soulema, Ronald H. Yueh, Maren T. Scheuner, Michael F. Holick, Russell Christensen, Tracey L. Tajima, Angela M. Leung, Sanjay M. Mallya Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant disorder characterized by florid osseous dysplasia (FOD) in the jaws, bone fragility, and diap...περισσότερα »
Postobstructive Pulmonary Edema following Tonsillectomy/Adenoidectomy
Postobstructive Pulmonary Edema following Tonsillectomy/Adenoidectomy in a 2-Year-Old with Poland-Moebius Syndrome: A 2-year-old male with Poland-Moebius syndrome was transferred from a local hospital to the Pediatric ICU at Children’s Hospital of Georgia for suspected postobstructive pulmonary edema (POPE) after tonsillectomy/adenoidectomy (T&A). The patient’s respiratory status ultimately declined and he developed respiratory failure. Imaging suggested pulmonary edema as well as a left-sided pneumonia. Echocardiogram showed pulmonary hypertension and airway exam via direct fiberop... περισσότερα »
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT via Hearing Research Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.... περισσότερα »
Toxoplasma gondii by PCR detection in meat for human consumption
Survey for Toxoplasma gondii by PCR detection in meat for human consumption in Colombia: AbstractThe overall risk for toxoplasmosis in meat produced in Colombia is unknown. We analyzed by PCR assay meat samples for human consumption in two types of plants in Colombia: 120 samples from class I plants (60 samples from chicken, 30 from swine and 30 from beef) and 60 from class II plants (30 samples from beef and 30 from swine). Presence of *Toxoplasma* DNA was established by targeted B1 nested PCR assay. We detected 79 (43 %) samples that were positive by B1 nested PCR (33 from chicke... περισσότερα »
Complementary DNA (cDNA) library for trace mites
Improvement on the extraction method of RNA in mites and its quality test: AbstractTo solve the long-existing difficult problems in extracting RNA and constructing a complementary DNA (cDNA) library for trace mites, we conducted a further comparative experiment among three RNA extraction methods (TRIzol method, Omega method, and Azanno method) based on our previous attempts at the construction of cDNA library of mites, with *Psoroptes cuniculi* still used as the experimental subject. By subsequently decreasing the number of mites, the least number of mites needed for RNA extraction... περισσότερα »
Absence of human herpesvirus 6B detection in association with illness in children undergoing cancer chemotherapy
Absence of human herpesvirus 6B detection in association with illness in children undergoing cancer chemotherapy: ABSTRACT Background The lymphotropic herpesviruses, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6B (HHV-6B) can reactivate and cause disease in organ transplant recipients; the contributions of HHV-6A and HHV-7 to disease are less certain. Less is known about their pathogenic roles in children undergoing treatment for malignancies. Methods Children with newly diagnosed cancer were followed for 24 months. Clinical information and blood samples w... περισσότερα »
Fulminant hepatic and multiple organ failure following acute viral tonsillitis: a case report
Fulminant hepatic and multiple organ failure following acute viral tonsillitis: a case report: [image: s13256-015-0777-3-1.gif] Background: Pyogenic tonsillitis may often be observed in the general Western population. In severe cases, it may require antibiotic treatment or even hospitalization and often a prompt clinical response will be noted. Here we present an unusual case of progressive multiple organ failure including fulminant liver failure following acute tonsillitis initially mistaken for “classic” pyogenic (that is bacterial) tonsillitis.Case presentationA 68-year-old ... περισσότερα »
Angioimmunoblastic T Cell Lymphoma Mimicking Chronic Urticaria
Angioimmunoblastic T Cell Lymphoma Mimicking Chronic Urticaria: Angioimmunoblastic T cell lymphoma (AITL) is a rare but distinct type of T cell lymphoma with an aggressive course and high mortality. Most patients are diagnosed late in the disease and usually present with generalized lymphadenopathy. A minority have skin lesions at the time of diagnosis, more commonly in the form of nonspecific maculopapular rash with or without pruritus. We report a rare case of AITL presenting with chronic, recurrent angioedema and urticaria-like lesions and no palpable peripheral adenopathy. Prima... περισσότερα »
Aberrant cervical vasculature anastomosis as cause of neck pain and successful treatment with embolization technique
Aberrant cervical vasculature anastomosis as cause of neck pain and successful treatment with embolization technique: We report a patient with non-dermatomal radiating neck pain without focal neurologic deficit. Traditional workup could not identify an anatomic or biomechanical cause. Imaging showed a deep cervical vessel centered in the region of pain. Angiography later identified an aberrant anastomosis of this vessel with the occipital artery. Subsequent endovascular embolization of this arterial trunk resulted in complete pain relief.
CT and MR myelography with radioisotope cisternography (RC) for detection of spinal cerebrospinal (CSF) leaks
The utility of radioisotope cisternography in low CSF/volume syndromes compared to myelography: Objective The objective of this report is to compare computed tomography (CT) and magnetic resonance (MR) myelography with radioisotope cisternography (RC) for detection of spinal cerebrospinal (CSF) leaks. Methods We retrospectively reviewed 12 spontaneous intracranial hypotension (SIH) patients; CT and RC were performed simultaneously. Three patients had MR myelography. Results CT and/or MR myelography identified CSF leaks in four of 12 patients. RC detected spinal leaks in all three...περισσότερα »
Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia
Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia: Sepsis-associated encephalopathy (SAE) is characterized as brain dysfunction associated with sepsis. In this study we sought to investigate the effects of resveratrol in mice with SAE, as well as its effects in NLRP3 inflammasome and IL-1β, which were critical in the pathogenesis of SAE. SAE was induced in mice via cecal ligation and puncture (CLP), and resveratrol was administered at two doses after surgery. Spatial learning memory functions were evaluated by Morris water m...περισσότερα »
The thyroid hormone and cortisol signaling pathways
3,5-Diiodothyronine-mediated Transrepression of the thyroid hormone receptor beta gene in tilapia. insights on cross-talk between the thyroid hormone and cortisol signaling pathways via http://rss.sciencedirect.com/publication/science/03037207 Publication date: Available online 26 January 2016 *Source:*Molecular and Cellular Endocrinology Author(s): Gabriela Hernández-Puga, Pamela Navarrete-Ramírez, Arturo Mendoza, Aurora Olvera, Patricia Villalobos, Aurea Orozco T3 and cortisol activate or repress gene expression in virtually every vertebrate cell mainly by interacting with their nucle...περισσότερα »
The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms
The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms: AbstractFine needle aspiration cytology (FNAC) plays an essential role in the evaluation of thyroid nodules especially for the category of follicular neoplasms (FN) representing 25 % of all thyroid cases including different neoplastic entities. Hence, one of the most promising areas is the application of molecular tests to FNAC. Among them, microRNAs (miRNA),identified as negative (post-transcriptional) gene expression regulators involved in tumor development, are likely to discriminate... περισσότερα »
Surgical Management of Bulky Mediastinal Metastases in Follicular Thyroid Carcinoma.
*Surgical Management of Bulky Mediastinal Metastases in Follicular Thyroid Carcinoma.* Oman Med J. 2016 Jan;31(1):69-72 Authors: Adwin Z, Nur A, Suhaimi S, Rahman R Abstract Follicular thyroid adenoma and carcinoma are very common. Benign and malignant lesions are usually indistinguishable from cytology alone and often require confirmatory resection. The spread of follicular carcinoma is usually hematogenous and is treated with surgery and adjuvant radioactive iodine. Very rarely, metastases occur in the mediastinum. Patients usually present with severe compressive symptoms. Wit...περισσότερα »
The pterygopalatine recess of the superior nasal meatus.
*The pterygopalatine recess of the superior nasal meatus.* Surg Radiol Anat. 2016 Jan 27; Authors: Rusu MC, Săndulescu M, Derjac-Aramă AI Abstract The pneumatizations surrounding the pterygopalatine fossa (PPF) and closely related to the sphenopalatine foramen are anatomically variable. During the assessment of a cone beam computed tomography of a 64-year-old male patient, we found bilaterally a previously unreported anatomic variant. This was represented by a lateral or pterygopalatine recess (PPR) of the superior nasal meatus which extended in the anterior wall of the PPF and ...περισσότερα »
Bisphenol A: Targeting metabolic tissues
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The prevalence of obesity, metabolic syndrome and type 2 diabetes has dramatically increased worldwide over the last few decades. Although genetic predisposition and lifestyle factors like decreased physical activity and energy-dense diet are well-known factors in the pathophysiology of these conditions, accumulating evidence suggests that the increase in endocrine disrupting chemicals (EDCs) in the […]
A descriptive investigation of the impact of student research projects arising from elective research courses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Pharmacy academicians have noted the need to develop research skills in student pharmacists. At the Gatton College of Pharmacy, significant focus has been placed on the development of research skills through offering elective research courses. In order to evaluate the impact of participation in the research elective(s), we analyzed college records and surveyed […]
Toxicological study of the butanol fractionated root extract of Asparagus africanus Lam., on some blood parameter and histopathology of liver and kidney in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The butanol fractionated root extract of Asparagus africanus Lam., a traditional herb widely used to treat various ailments were analyzed for the presence of potential toxicity after single (acute) and repeated (subchronic) dose oral administration in adult swiss albino mice using gavages. Methods For the acute study, butanol fractionated extract of the plant […]
Prenatal exposure to flame retardants linked to poorer behavioral function in children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
New research from the University of Cincinnati (UC) College of Medicine suggests that prenatal exposure to flame retardants and perfluoroalkyl substances (PFASs) commonly found in the environment… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20uypFp via IFTTT
Smartphones and intelligent socks to help prevent diabetic amputations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Diabetic neuropathy is a type of nerve damage associated with the development of foot ulcers in patients with diabetes. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/207s4Dh via IFTTT
Erratum to: Current and Novel Aspects on the Non-lysosomal β-Glucosylceramidase GBA2
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Providencia stuartii Isolates from Greece: Co-Carriage of Cephalosporin (blaSHV-5, blaVEB-1), Carbapenem (blaVIM-1), and Aminoglycoside (rmtB) Resistance Determinants by a Multidrug-Resistant Outbreak Clone
Providencia stuartii Isolates from Greece: Co-Carriage of Cephalosporin (blaSHV-5, blaVEB-1), Carbapenem (blaVIM-1), and Aminoglycoside (rmtB) Resistance Determinants by a Multidrug-Resistant Outbreak Clone: Microbial Drug Resistance , Vol. 0, No. 0. Author information Olga Oikonomou,1,* Apostolos Liakopoulos,2,* Lynette M. Phee,1 Jonathan Betts,1 Dik Mevius,2 andDavid W. Wareham1 1Antimicrobial Research Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom. 2Department of Bacteriology and TSEs, Centra... περισσότερα »
Reliable Estimation of Atopic Dermatitis in Childhood (REACH) criteria
Various diagnostic criteria for atopic dermatitis (AD): A proposal of Reliable Estimation of Atopic Dermatitis in Childhood (REACH) criteria, a novel questionnaire-based diagnostic tool for AD: Abstract Atopic dermatitis (AD) is a heterogeneous disease that manifests with a wide variety of clinical symptoms and signs. Due to the lack of definitive biomarkers for AD, it is very difficult to set up standard diagnostic criteria for AD which cover the entire spectrum of AD patients. Various instruments have been proposed for AD diagnosis, and they can be classified into a hospital sett... περισσότερα »
Acne-related post-inflammatory hyperpigmentation
Frequency and characteristics of acne-related post-inflammatory hyperpigmentation: Abstract In patients with darker skin types (Fitzpatrick phototypes III–VI), acne is often accompanied by post-inflammatory hyperpigmentation (PIH). Further, acne-related pigmentation can pose a greater concern for the patient than the acne lesions. There has been little formal study of this acne-related PIH. Recently, the Asian Acne Board – an international group of dermatologists with interest in acne research – made a preliminary evaluation of the frequency and characteristics of PIH in seven Asia... περισσότερα »
High fever, arthralgia, erythema and leg edema : Chikungunya fever
Two Japanese siblings affected with Chikungunya fever with different clinical courses: Imported infections from the Cook Islands: Abstract Two Japanese siblings visited the Cook Islands on business and stayed for 2 months. The sister developed a high fever, arthralgia, erythema and leg edema on the day after returning to Japan. The brother also developed neck and joint pain on the day following the sister's onset. Subsequently, his erythematous lesions spread over his whole body. Chikungunya virus was detected from the sister's blood and urine by specific reverse transcription poly... περισσότερα »
Recurrent neutrophilic dermatosis of the face
Recurrent neutrophilic dermatosis of the face: A report of two cases and review of the published work: Abstract Recurrent neutrophilic dermatosis of the face is a disease that is morphologically and histopathologically compatible with Sweet's syndrome, but is distributed on the face without fever, laboratory abnormalities or associated disorders. At present, it is unclear whether our cases belong to the chronic and mild variant of Sweet's syndrome or are independent entities. Here, we present two cases of recurrent neutrophilic dermatosis of the face with good response to systemic ... περισσότερα »
Melanoma therapy: The Ras/Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway plays a key role in melanomagenesis
Melanoma therapy: Check the checkpoints: Abstract Recent mutational and translational studies have revealed that the Ras/Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway plays a key role in melanomagenesis. Mutations in *NRAS* and *BRAF* are found in the majority of melanomas resulting in the formation of constitutively active NRAS and BRAF molecules, which leads to the proliferation and survival of melanoma cells through the activation of MEK/ERK signals. Inhibitors of BRAF or MEK significantly extend the progression-free surviv...περισσότερα »
Melanoma therapy: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is an immune checkpoint molecule that downregulates T-cell activation by binding to B7 (CD80/CD86) molecules on antigen-presenting cells. Programmed death receptor ligand 1 on melanoma cells negatively regulates T-cell function by binding to the programmed death-1 (PD-1) receptor on T cells.
Melanoma therapy: Check the checkpoints: Abstract Recent mutational and translational studies have revealed that the Ras/Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway plays a key role in melanomagenesis. Mutations in *NRAS* and *BRAF* are found in the majority of melanomas resulting in the formation of constitutively active NRAS and BRAF molecules, which leads to the proliferation and survival of melanoma cells through the activation of MEK/ERK signals. Inhibitors of BRAF or MEK significantly extend the progression-free surviv...περισσότερα »
Investigating the Role of Helicobacter pylori PriA Protein
Investigating the Role of Helicobacter pylori PriA Protein: Abstract Background In bacteria, PriA protein, a conserved DEXH-type DNA helicase, plays a central role in replication restart at stalled replication forks. Its unique DNA binding property allows it to recognize and stabilize stalled forks and the structures derived from them. PriA plays a very critical role in replication fork stabilization and DNA repair in *E. coli* and *N. gonorrhoeae*. In our in vivo expression technology screen, *pri*A gene was induced in vivo when *Helicobacter pylori* infects mouse stomach. Material... περισσότερα »
Early Molecular Events in Epithelial Cells Mediated by Helicobacter pylori CagA
Early Molecular Events in Murine Gastric Epithelial Cells Mediated by Helicobacter pylori CagA: Abstract Background Murine models of *Helicobacter pylori* infection are used to study host–pathogen interactions, but lack of severe gastritis in this model has limited its usefulness in studying pathogenesis. We compared the murine gastric epithelial cell line GSM06 to the human gastric epithelial AGS cell line to determine whether similar events occur when cultured with *H. pylori*. Materials and Methods The lysates of cells infected with *H. pylori* isolates or an isogenic *cagA*-def... περισσότερα »
Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Purpose: Computed tomography perfusion (CTP) has a high diagnostic value in the detection of acute ischemic stroke in the anterior circulation. However, the diagnostic value in suspected posterior circulation (PC) stroke is uncertain, and whole brain volume perfusion is not yet in widespread use. We therefore studied the additional value of whole brain […]
Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: Recent evidence suggests that a potential harmful relationship exists between cannabis use and ischemic stroke. The purpose of this study was to determine the implications of cannabis use in intracerebral hemorrhage (ICH) patients. Methods: An analysis of an international, multicenter, observational database of consecutive patients with spontaneous ICH was conducted. We extracted the following […]
«Mir geht es gut!» Gesundheitsvorstellungen von Männern in der Schweiz. Ergebnisse aus einem empirischen Projekt
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
On the search for explanations of the ‘gender gap’ in differential life expectancies between men and women, the connection between health actions and gender constructions has come under consideration. The article presents the results of qualitative interviews with forty Swiss men aged between thirty and sixty on their subjective perceptions of health and health actions. […]
Monoclonal antibodies that recognize the alkylation signature of antimalarial ozonides OZ277 (Arterolane) and OZ439 ( Artefenomel)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Genes, Vol. 7, Pages 8: Molecular Characteristic, Protein Distribution and Potential Regulation of HSP90AA1 in the Anadromous Fish Coilia nasus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Heat shock proteins play essential roles in basic cellular events. Spawning migration is a complex process, with significant structural and biochemical changes taking place in the adult gonad. To date, the molecular mechanisms underlying migration reproductive biology remain undetermined. In this regard, a full length HSP90AA1 comprising 2608 nucleotides from the anadromous fish Coilia nasus […]
The Geography of Mental Health and General Wellness in Galveston Bay After Hurricane Ike: A Spatial Epidemiologic Study With Longitudinal Data
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles Oliver Gruebner, Sarah R. Lowe, Melissa Tracy, Magdalena Cerdá, Spruha Joshi, Fran H. Norris, Sandro Galea Disaster Medicine and Public Health Preparedness,FirstView Article(s), 13 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SdkgeI via IFTTT
Proactive Management for Gastric, Colorectal and Appendiceal Malignancies: Preventing Peritoneal Metastases with Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract An integrated treatment strategy using peritonectomy procedures plus hyperthermic intraperitoneal chemotherapy (HIPEC) is now a clinical standard of care in selected patients with peritoneal metastases and primary peritoneal tumors. This comprehensive approach can offer many patients, who hitherto had no hope of cure, a good quality of life and survival despite limited morbidity. The […]
Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Purpose: Computed tomography perfusion (CTP) has a high diagnostic value in the detection of acute ischemic stroke in the anterior circulation. However, the diagnostic value in suspected posterior circulation (PC) stroke is uncertain, and whole brain volume perfusion is not yet in widespread use. We therefore studied the additional value of whole brain […]
Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: Recent evidence suggests that a potential harmful relationship exists between cannabis use and ischemic stroke. The purpose of this study was to determine the implications of cannabis use in intracerebral hemorrhage (ICH) patients. Methods: An analysis of an international, multicenter, observational database of consecutive patients with spontaneous ICH was conducted. We extracted the following […]
«Mir geht es gut!» Gesundheitsvorstellungen von Männern in der Schweiz. Ergebnisse aus einem empirischen Projekt
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
On the search for explanations of the ‘gender gap’ in differential life expectancies between men and women, the connection between health actions and gender constructions has come under consideration. The article presents the results of qualitative interviews with forty Swiss men aged between thirty and sixty on their subjective perceptions of health and health actions. […]
Knockdown of CLIC4 enhances ATP-induced HN4 cell apoptosis through mitochondrial and endoplasmic reticulum pathways.
*Knockdown of CLIC4 enhances ATP-induced HN4 cell apoptosis through mitochondrial and endoplasmic reticulum pathways.* Cell Biosci. 2016;6:5 Authors: Xue H, Lu J, Yuan R, Liu J, Liu Y, Wu K, Wu J, Du J, Shen B Abstract BACKGROUND: Human head and neck squamous carcinoma is the 6th most prevalent carcinoma worldwide. Although many novel therapies have been developed, the clinical treatment for patients remains non-ideal. Chloride intracellular channel 4 (CLIC4), one of the seven members of the CLIC family, is a newly found Cl(-) channel that participates in various biological proc... περισσότερα »
Antithyroid Drug Side Effects in the Population and in Pregnancy.
*Antithyroid Drug Side Effects in the Population and in Pregnancy.* J Clin Endocrinol Metab. 2016 Jan 27;:jc20154274 Authors: Andersen SL, Olsen J, Laurberg P Abstract OBJECTIVE: Methimazole (MMI) and Propylthiouracil (PTU) are both associated with birth defects, and may also rarely be associated with agranulocytosis and liver failure. The frequency of these side effects when antithyroid drugs (ATD) are used in the population in general or in pregnancy remains to be elucidated. DESIGN: All individuals registered as the parent of a live-born child in Denmark, 1973-2008, were ident...περισσότερα »
Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.
*Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.* J Clin Endocrinol Metab. 2016 Jan 27;:jc20153518 Authors: Jujić A, Nilsson PM, Persson M, Holst JJ, Torekov SS, Lyssenko V, Groop L, Melander O, Magnusson M Abstract Context We have previously shown that high levels of atrial natriuretic peptides (ANP) are associated with decreased risk of future diabetes development; however, the mechanism behind this relationship is not fully understood. OBJECTIVE: In this study, we prospectively analyzed whether baseline plasma lev...περισσότερα »
Soy Intake Modifies the Relation Between Urinary Bisphenol A Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction.
*Soy Intake Modifies the Relation Between Urinary Bisphenol A Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction.* J Clin Endocrinol Metab. 2016 Jan 27;:jc20153473 Authors: Chavarro JE, Mínguez-Alarcón L, Chiu YH, Gaskins AJ, Souter I, Williams PL, Calafat AM, Hauser R, EARTH Study Team Abstract CONTEXT: Experimental data in rodents suggest that the adverse reproductive health effects of bisphenol A (BPA) can be modified by intake of soy phytoestrogens. Whether the same is true in humans is not known. OBJECTIVE: The purpose of this study was to eva... περισσότερα »
Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein.* Cancer Gene Ther. 2015 Mar;22(4):215-21 Authors: Lears KA, Parry JJ, Andrews R, Nguyen K, Wadas TJ, Rogers BE Abstract Suicide gene therapy is a process by which cells are administered a gene that encodes a protein capable of converting a nontoxic prodrug into an active toxin. Cytosine deaminase (CD) has been widely investigated as a means of suicide gene therapy owing to the en... περισσότερα »
Gene therapy for radioprotection.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Gene therapy for radioprotection.* Cancer Gene Ther. 2015 Mar;22(4):172-80 Authors: Everett WH, Curiel DT Abstract Radiation therapy is a critical component of cancer treatment with over half of patients receiving radiation during their treatment. Despite advances in image-guided therapy and dose fractionation, patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues. To reduce normal tissue damage, researchers have sou... περισσότερα »
Abstracts presented at the 52nd Annual Meeting of the American Society of Dermatopathology
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Ice-pack Dermatosis: A Diagnositic Pitfall for Dermatopathologists that Mimics Lupus Erythematosus
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2015 Reviewer Thank You
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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The pterygopalatine recess of the superior nasal meatus.
*The pterygopalatine recess of the superior nasal meatus.* Surg Radiol Anat. 2016 Jan 27; Authors: Rusu MC, Săndulescu M, Derjac-Aramă AI Abstract The pneumatizations surrounding the pterygopalatine fossa (PPF) and closely related to the sphenopalatine foramen are anatomically variable. During the assessment of a cone beam computed tomography of a 64-year-old male patient, we found bilaterally a previously unreported anatomic variant. This was represented by a lateral or pterygopalatine recess (PPR) of the superior nasal meatus which extended in the anterior wall of the PPF and ...περισσότερα »
[Exploratory study of 3D printing technique in the treatment of basilar invagination and atlantoaxial dislocation].
*[Exploratory study of 3D printing technique in the treatment of basilar invagination and atlantoaxial dislocation].* Zhonghua Yi Xue Za Zhi. 2015 Oct 6;95(37):3004-7 Authors: Yin Y, Yu X, Tong H, Xu T, Wang P, Qiao G Abstract OBJECTIVE: To investigate the clinical application value of the 3D printing technique in the treatment of basilar invagination and atlantoaxial dislocation. METHODS: From January 2013 to September 2013, 10 patients with basilar invagination and atlantoaxial dislocation needing posterior fixation undertook 3D printing modes at the Department of Neurosurgery ... περισσότερα »
Abstracts presented at the 52nd Annual Meeting of the American Society of Dermatopathology
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Ice-pack Dermatosis: A Diagnositic Pitfall for Dermatopathologists that Mimics Lupus Erythematosus
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Abstracts presented at the 52nd Annual Meeting of the American Society of Dermatopathology
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Ice-pack Dermatosis: A Diagnositic Pitfall for Dermatopathologists that Mimics Lupus Erythematosus
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American Board of Dermatology Examination Dates
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Ten Years of Theta Burst Stimulation in Humans: Established Knowledge, Unknowns and Prospects
[image: alertIcon.gif] Publication date: Available online 27 January 2016 *Source:*Brain Stimulation Author(s): A. Suppa, Y.Z. Huang, K. Funke, M.C. Ridding, B. Cheeran, V. Di Lazzaro, U. Ziemann, J.C. Rothwell Background/ObjectivesOver the last ten years, an increasing number of authors have used the theta burst stimulation (TBS) protocol to investigate long-term potentiation (LTP) and long-term depression (LTD)-like plasticity non-invasively in the primary motor cortex (M1) in healthy humans and in patients with various types of movement disorders. We here provide a comprehensive ... περισσότερα »
IJERPH, Vol. 13, Pages 178: Child Wasting in Emergency Pockets: A Meta-Analysis of Small-Scale Surveys from Ethiopia
Child undernutrition is a major public health concern in Ethiopia (stunting national prevalence: 44%; wasting: 10%), despite the overall improvement in child health status during the last decade. Hundreds of small-scale surveys are conducted in Ethiopia’s emergency pockets under ENCU’s supervision. We reviewed the evidence from small-scale surveys conducted between 2008 and 2013 with two… Continue reading IJERPH, Vol. 13, Pages 178: Child Wasting in Emergency Pockets: A Meta-Analysis of Small-Scale Surveys from Ethiopia
Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke
Background and Purpose: Computed tomography perfusion (CTP) has a high diagnostic value in the detection of acute ischemic stroke in the anterior circulation. However, the diagnostic value in suspected posterior circulation (PC) stroke is uncertain, and whole brain volume perfusion is not yet in widespread use. We therefore studied the additional value of whole brain… Continue reading Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke
Antibiotics, Vol. 5, Pages 10: Identification of a Fragment-Based Scaffold that Inhibits the Glycosyltransferase WaaG from Escherichia coli
WaaG is a glycosyltransferase that is involved in the biosynthesis of lipopolysaccharide in Gram-negative bacteria. Inhibitors of WaaG are highly sought after as they could be used to inhibit the biosynthesis of the core region of lipopolysaccharide, which would improve the uptake of antibiotics. Herein, we establish an activity assay for WaaG using 14C-labeled UDP-glucose… Continue reading Antibiotics, Vol. 5, Pages 10: Identification of a Fragment-Based Scaffold that Inhibits the Glycosyltransferase WaaG from Escherichia coli
Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage
Objective: Recent evidence suggests that a potential harmful relationship exists between cannabis use and ischemic stroke. The purpose of this study was to determine the implications of cannabis use in intracerebral hemorrhage (ICH) patients. Methods: An analysis of an international, multicenter, observational database of consecutive patients with spontaneous ICH was conducted. We extracted the following… Continue reading Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage
“Mir geht es gut!” Gesundheitsvorstellungen von Männern in der Schweiz. Ergebnisse aus einem empiri schen Projekt
On the search for explanations of the ‘gender gap’ in differential life expectancies between men and women, the connection between health actions and gender constructions has come under consideration. The article presents the results of qualitative interviews with forty Swiss men aged between thirty and sixty on their subjective perceptions of health and health actions.… Continue reading “Mir geht es gut!” Gesundheitsvorstellungen von Männern in der Schweiz. Ergebnisse aus einem empiri schen Projekt
Evaluation of the changes of P1NP and CTX in synovial fluid and blood serum of dogs with experimental osteoarthritis
Abstract Osteoarthritis is a degenerative and reparative process occurring in synovial joints. In the present study, collagen type I C-telopeptide (CTX) and procollagen type I N-terminal propeptide (P1NP) were measured in blood serum and synovial fluid of four cross-breed dogs with experimental CCL rupture. These biomarkers were selected as bone turnover biomarkers. The markers were… Continue reading Evaluation of the changes of P1NP and CTX in synovial fluid and blood serum of dogs with experimental osteoarthritis
Biosynthesis of 3″-demethyl-gentamicin C components by genN disruption strain of Micromonospora echinospora and test their antimicrobial activities in vitro
Publication date: Available online 28 January 2016 Source:Microbiological Research Author(s): Xianpu Ni, Tingting Zong, Hongyu Zhang, Yawen Gu, Miaoling Huang, Wei Tian, Huanzhang Xia Gentamicin consists primarily of four components, which have different patterns of methylation at C-6′ position. The methyl groups have a significant impact on gentamicin antimicrobial activity. Sequence analysis predicted that GenN… Continue reading Biosynthesis of 3″-demethyl-gentamicin C components by genN disruption strain of Micromonospora echinospora and test their antimicrobial activities in vitro
Monoclonal antibodies that recognize the alkylation signature of antimalarial ozonides OZ277 (Arterolane) and OZ439 ( Artefenomel)
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lW7cMg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SLPaup via IFTTT
Genes, Vol. 7, Pages 8: Molecular Characteristic, Protein Distribution and Potential Regulation of HSP90AA1 in the Anadromous Fish Coilia nasus
Heat shock proteins play essential roles in basic cellular events. Spawning migration is a complex process, with significant structural and biochemical changes taking place in the adult gonad. To date, the molecular mechanisms underlying migration reproductive biology remain undetermined. In this regard, a full length HSP90AA1 comprising 2608 nucleotides from the anadromous fish Coilia nasus… Continue reading Genes, Vol. 7, Pages 8: Molecular Characteristic, Protein Distribution and Potential Regulation of HSP90AA1 in the Anadromous Fish Coilia nasus
KatB, a cyanobacterial mn-catalase with unique active site configuration: Implications for enzyme function
Publication date: Available online 27 January 2016 Source:Free Radical Biology and Medicine Author(s): Subhash C Bihani, Dhiman Chakravarty, Anand Ballal Manganese catalases (Mn-catalases), a class of H2O2 detoxifying proteins, are structurally and mechanistically distinct from the commonly occurring catalases, which contain heme. Active site of Mn-catalases can serve as template for the synthesis of catalase… Continue reading KatB, a cyanobacterial mn-catalase with unique active site configuration: Implications for enzyme function
«Mir geht es gut!» Gesundheitsvorstellungen von Männern in der Schweiz. Ergebnisse aus einem empirischen Projekt
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
On the search for explanations of the ‘gender gap’ in differential life expectancies between men and women, the connection between health actions and gender constructions has come under consideration. The article presents the results of qualitative interviews with forty Swiss men aged between thirty and sixty on their subjective perceptions of health and health actions. […]
Monoclonal antibodies that recognize the alkylation signature of antimalarial ozonides OZ277 (Arterolane) and OZ439 ( Artefenomel)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1lW7cMg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Genes, Vol. 7, Pages 8: Molecular Characteristic, Protein Distribution and Potential Regulation of HSP90AA1 in the Anadromous Fish Coilia nasus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Heat shock proteins play essential roles in basic cellular events. Spawning migration is a complex process, with significant structural and biochemical changes taking place in the adult gonad. To date, the molecular mechanisms underlying migration reproductive biology remain undetermined. In this regard, a full length HSP90AA1 comprising 2608 nucleotides from the anadromous fish Coilia nasus […]
Effect of levodopa-carbidopa intestinal gel on dyskinesia in advanced Parkinson’s disease patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Objective The purpose of this study was to assess the effect of levodopa-carbidopa intestinal gel (carbidopa-levodopa enteral suspension) in advanced Parkinson’s disease patients with troublesome dyskinesia. Methods Post hoc analyses of patient data from a 12-week, randomized, double-blind study and a 54-week open-label study were performed. Efficacy was assessed in the subgroup of patients […]
The Geography of Mental Health and General Wellness in Galveston Bay After Hurricane Ike: A Spatial Epidemiologic Study With Longitudinal Data
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles Oliver Gruebner, Sarah R. Lowe, Melissa Tracy, Magdalena Cerdá, Spruha Joshi, Fran H. Norris, Sandro Galea Disaster Medicine and Public Health Preparedness,FirstView Article(s), 13 pages Abstract from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SdkgeI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Il video shock: legano un petardo al collo di un gabbiano e lo fanno esplodere in volo VIDEO – Meteo Web
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Meteo Web Il video shock: legano un petardo al collo di un gabbiano e lo fanno esplodere in volo [VIDEO] Meteo Web Non ha una data, quindi non si sa quando sia successo, ma le immagini sono davvero scioccanti. Si tratta di un video postato su Facebook da un utente di Thiesi, Sassari, e presente […]
Don’t miss Dr Eduardo Cazap’s talk at our Buenos Aires Prostate Cancer Symposium! https://t.co/9iOQMdw Mr9 – register now! @ecancer_espanol
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Don’t miss Dr Eduardo Cazap’s talk at our Buenos Aires Prostate Cancer Symposium! https://t.co/9iOQMdwMr9 – register now! @ecancer_espanol from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/692664912347295744 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
RT @SDawsonBerlin : Nice! @ecancer has 470 Open Access articles on @Science_Open . Filter by #Altmetric score: #women shealth tops list https:…
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
RT @SDawsonBerlin : Nice! @ecancer has 470 Open Access articles on @Science_Open . Filter by #Altmetric score: #womenshealth tops list https:… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/692641481832685568 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
IJERPH, Vol. 13, Pages 168: Association between Floods and Acute Cardiovascular Diseases: A Population-Based Cohort Study Using a Geographic Information System Approach
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Floods represent a serious threat to human health beyond the immediate risk of drowning. There is few data on the potential link between floods and direct consequences on health such as on cardiovascular health. This study aimed to explore the impact of one of the worst floods in the history of Quebec, Canada on […]
IJERPH, Vol. 13, Pages 178: Child Wasting in Emergency Pockets: A Meta-Analysis of Small-Scale Surveys from Ethiopia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Child undernutrition is a major public health concern in Ethiopia (stunting national prevalence: 44%; wasting: 10%), despite the overall improvement in child health status during the last decade. Hundreds of small-scale surveys are conducted in Ethiopia’s emergency pockets under ENCU’s supervision. We reviewed the evidence from small-scale surveys conducted between 2008 and 2013 with two […]
Runners with patellofemoral pain have altered biomechanics which targeted interventions can modify: A systematic review and meta-analysis
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Bradley S. Neal, Christian J. Barton, Rosa Gallie, Patrick O’Halloran, Dylan Morrissey Patellofemoral pain (PFP) is the most prevalent running pathology and associated with multi-level biomechanical factors. This systematic review aims to guide treatment and prevention of PFP by synthesising prospective, observational and intervention studies that measure clinical and biomechanical outcomes in symptomatic running populations. Medline, Web of Science and CINAHL were searched from inception to April 2015 for pro... περισσότερα »
Runners with patellofemoral pain have altered biomechanics which targeted interventions can modify: A systematic review and meta-analysis
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Bradley S. Neal, Christian J. Barton, Rosa Gallie, Patrick O’Halloran, Dylan Morrissey Patellofemoral pain (PFP) is the most prevalent running pathology and associated with multi-level biomechanical factors. This systematic review aims to guide treatment and prevention of PFP by synthesising prospective, observational and intervention studies that measure clinical and biomechanical outcomes in symptomatic running populations. Medline, Web of Science and CINAHL were searched from inception to April 2015 for pro... περισσότερα »
Runners with patellofemoral pain have altered biomechanics which targeted interventions can modify: A systematic review and meta-analysis
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Bradley S. Neal, Christian J. Barton, Rosa Gallie, Patrick O’Halloran, Dylan Morrissey Patellofemoral pain (PFP) is the most prevalent running pathology and associated with multi-level biomechanical factors. This systematic review aims to guide treatment and prevention of PFP by synthesising prospective, observational and intervention studies that measure clinical and biomechanical outcomes in symptomatic running populations. Medline, Web of Science and CINAHL were searched from inception to April 2015 for pro... περισσότερα »
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allo... περισσότερα »
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allo... περισσότερα »
3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT
Publication date: Available online 28 January 2016 *Source:*Hearing Research Author(s): Joris AM. Soons, Femke Danckaers, William Keustermans, Toon Huysmans, Jan Sijbers, Jan W. Casselman, Joris JJ. Dirckx Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones.We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allo... περισσότερα »
Antibiotics, Vol. 5, Pages 10: Identification of a Fragment-Based Scaffold that Inhibits the Glycosyltransferase WaaG from Escherichia coli
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
WaaG is a glycosyltransferase that is involved in the biosynthesis of lipopolysaccharide in Gram-negative bacteria. Inhibitors of WaaG are highly sought after as they could be used to inhibit the biosynthesis of the core region of lipopolysaccharide, which would improve the uptake of antibiotics. Herein, we establish an activity assay for WaaG using 14C-labeled UDP-glucose […]
Liposomal Amphotericin B (AmBisome ® ): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Liposomal amphotericin B (AmBisome®; LAmB) is a unique lipid formulation of amphotericin B. LAmB is a standard of care for a wide range of medically important opportunistic fungal pathogens. LAmB has a significantly improved toxicity profile compared with conventional amphotericin B deoxycholate (DAmB). Despite nearly 20 years of clinical use, the pharmacokinetics and pharmacodynamics […]
Biosynthesis of 3″-demethyl-gentamicin C components by genN disruption strain of Micromonospora echinospora and test their antimicrobial activities in vitro
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 28 January 2016 Source:Microbiological Research Author(s): Xianpu Ni, Tingting Zong, Hongyu Zhang, Yawen Gu, Miaoling Huang, Wei Tian, Huanzhang Xia Gentamicin consists primarily of four components, which have different patterns of methylation at C-6′ position. The methyl groups have a significant impact on gentamicin antimicrobial activity. Sequence analysis predicted that GenN […]
Atmosphere, Vol. 7, Pages 17: Carbon Sequestration and Carbon Markets for Tree-Based Intercropping Systems in Southern Quebec, Canada
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Since agriculture directly contributes to global anthropogenic greenhouse gas (GHG) emissions, integrating trees into agricultural landscapes through agroforestry systems is a viable adaptive strategy for climate change mitigation. The objective of this study was to evaluate the carbon (C) sequestration and financial benefits of C sequestration according to Quebec’s Cap-and-Trade System for Greenhouse Gas Emissions […]
Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients’ moods, and those with depression or anxiety have worse outcomes. Approximately one-third of people with OA have mood problems. Cognitive behavioural therapy (CBT), a psychological therapy, is recommended by the National Institute for Health […]
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