A Diversity and Inclusion Framework for Medical Education.
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A newly approved drug for a rare group of diseases: Dichlorphenamide for periodic paralysis
The periodic paralyses constitute a group of autosomal dominantly inherited myopathies characterized by acute and reversible attacks of muscle weakness associated with changes in serum potassium levels. In addition to paralytic episodes, patients may develop persistent and progressive muscle weakness. Over the past 2 decades, the periodic paralyses have been models for basic and translational… Continue reading A newly approved drug for a rare group of diseases: Dichlorphenamide for periodic paralysis
Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases
Objective: To describe the clinical features, etiology, findings from neuroimaging, and treatment results in a series of 29 patients with Holmes tremor (HT). Methods: A retrospective study was performed based on review of medical records and videos of patients with HT diagnosis. Results: A total of 16 women and 13 men were included. The mean… Continue reading Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases
Recommendations for observational studies of comorbidity in multiple sclerosis
Objective: To reach consensus about the most relevant comorbidities to study in multiple sclerosis (MS) with respect to incidence, prevalence, and effect on outcomes; review datasets that may support studies of comorbidity in MS; and identify MS outcomes that should be prioritized in such studies. Methods: We held an international workshop to meet these objectives,… Continue reading Recommendations for observational studies of comorbidity in multiple sclerosis
Spinal muscular atrophy: A preliminary result toward new therapy
Spinal muscular atrophy (SMA) is an anterior horn cell disease characterized by severe muscle atrophy and weakness,1 traditionally divided into 4 subtypes.2 Type I SMA (Werdnig-Hoffman disease) is the most severe form, associated with extreme weakness and hypotonia since birth or early infancy. These patients never sit independently. In most cases, respiratory muscle dysfunction results… Continue reading Spinal muscular atrophy: A preliminary result toward new therapy
EEG and cardiac arrest: Divining prognosis at the bedside
Out-of-hospital cardiac arrest affects 326,200 persons in the United States each year.1 Mortality remains high despite advances in critical care and emergency response, with only 31.4% of patients surviving to hospital discharge.1 Survivors also face the prospect of disability due to hypoxic-ischemic brain injury. Prognostication is an important aspect of care in these patients, so… Continue reading EEG and cardiac arrest: Divining prognosis at the bedside
Age at onset and Parkinson disease phenotype
Objective: To explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated PD. Methods: We have analyzed baseline data from the Parkinson’s Progression Markers Initiative database. Four hundred twenty-two patients with a diagnosis of PD confirmed by DaTSCAN imaging were divided into 4 groups according… Continue reading Age at onset and Parkinson disease phenotype
STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy
Objective: To give a comprehensive overview of the phenotypic and genetic spectrum of STXBP1 encephalopathy (STXBP1-E) by systematically reviewing newly diagnosed and previously reported patients. Methods: We recruited newly diagnosed patients with STXBP1 mutations through an international network of clinicians and geneticists. Furthermore, we performed a systematic literature search to review the phenotypes of all… Continue reading STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy
Biomarkers for the progression of Parkinson disease
The chief outlay for a study of the progression of Parkinson disease (PD) is time, and many of the important scientific returns from the Parkinson’s Progression Markers Initiative database lie in the future. Pagano et al.1 have conducted a cross-sectional survey of the de novo PD patient cohort. One of their conclusions is that older… Continue reading Biomarkers for the progression of Parkinson disease
Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study
Objective: To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) of the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). Methods: A total of 742 patients entered the extension. Teriflunomide-treated patients continued the original dose; those previously receiving placebo were randomized 1:1 to… Continue reading Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study
Single-session soft palate interstitial radiofrequency surgery for habitual snoring
Limited long-term outcome of single-session soft palate interstitial radiofrequency surgery for habitual snoring in tertiary care academic referral centre: Our experience on 77 patients: Soft palate interstitial radiofrequency surgery (SPIRFS) has proven short-term benefits for habitual snoring, but its long-term effects are largely unknown. The long-term outcome of SPIRFS was assessed with symptom questionnaire of 77 patients with mean follow-up 7.35 years (range, 6.29-8.59). Only 14% of the treated patients had favorable outcome indicating that SPIRFS as a single treatment modalit... περισσότερα »
Blind Sac Closure for the chronically discharging ear
Blind Sac Closure: A safe and effective management option for the chronically discharging ear: 1.Blind sac closure is a very effective way of managing the chronically discharging ear in the presence of a profound hearing loss, or large conductive losses not amenable to surgical correction. 2.It is associated with a low rate of complications and recurrent disease. 3.Rehabilitation of hearing post procedure is viable and may be accomplished through bone anchored hearing systems, cochlear implantation or middle ear implantation. 4.Bone anchored hearing systems have the advantage of not ... περισσότερα »
When to treat anaphylaxis
Remember 2 Things: When to treat anaphylaxis: Anaphylaxis is a challenging patient presentation. Learn two signs to identify a life-threatening allergic reaction that demands aggressive treatment. If a patient has airway compromise, upper or lower, or signs of shock immediately treat with epinephrine and other protocol-authorized interventions. After watching read more about anaphylaxis assessment and treatment.
Anaphylaxis and lower airway assessment
Remember 2 Things: Anaphylaxis and lower airway assessment: Anaphylaxis is a difficult patient presentation. Review two important assessments for lower airway compromise caused by an allergic reaction. Auscultate the patient's lungs for wheezes, starting in the upper lung lobes and listening downward. Also make sure you can distinguish absent lung sounds from clear lung sounds. Finally, remember to listen to lots and lots of lung sounds so you can learn to distinguish ...
The “Sniffin’ Sticks” Smell Test: Reliability, Validity, and Normative Data
Cultural Adaptation of the Portuguese Version of the “Sniffin’ Sticks” Smell Test: Reliability, Validity, and Normative Data: by João Carlos Ribeiro, João Simões, Filipe Silva, Eduardo D. Silva, Cornelia Hummel, Thomas Hummel, António Paiva The cross-cultural adaptation and validation of the Sniffin`Sticks test for the Portuguese population is described. Over 270 people participated in four experiments. In Experiment 1, 67 participants rated the familiarity of presented odors and seven descriptors of the original test were adapted to a Portuguese context. In Experiment 2, the Portu... περισσότερα »
The effects of anterior palatoplasty on floppy eyelid syndrome patients with obstructive sleep apnea
The effects of anterior palatoplasty on floppy eyelid syndrome patients with obstructive sleep apnea: Objectives/Hypothesis To investigate the effects of anterior palatoplasty on the presence and stage of floppy eyelid syndrome (FES) among patients diagnosed with mild or moderate obstructive sleep apnea (OSA) according to the apnea-hypopnea index (AHI). Study Design Prospective controlled trial. Methods Those patients whose AHI scores were between 5 and 30 according to full-night polysomnography were included in the study. The patients in whom anterior palatoplasty was performed wer... περισσότερα »
Biomarkers for the progression of Parkinson disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
The chief outlay for a study of the progression of Parkinson disease (PD) is time, and many of the important scientific returns from the Parkinson’s Progression Markers Initiative database lie in the future. Pagano et al.1 have conducted a cross-sectional survey of the de novo PD patient cohort. One of their conclusions is that older […]
Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Objective: To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) of the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). Methods: A total of 742 patients entered the extension. Teriflunomide-treated patients continued the original dose; those previously receiving placebo were randomized 1:1 to […]
Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Objective: To determine whether poor cardiovascular (CV) fitness and exaggerated exercise blood pressure (BP) and heart rate (HR) were associated with worse brain morphology in later life. Methods: Framingham Offspring participants (n = 1,094, 53.9% female) free from dementia and CV disease (CVD) underwent an exercise treadmill test at a mean age of 40 ± […]
Urinary LRRK2 phosphorylation: Penetrating the thicket of Parkinson disease?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
While the discovery of the first monogenic cause of Parkinson disease (PD) almost 2 decades ago has revolutionized our understanding of this increasingly prevalent disorder, genotype–phenotype relationships have proven to be much more complex than initially anticipated. An important reason for this observation is reduced penetrance, a conundrum referring to the surprisingly large proportion of […]
TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
American Journal of Human Genetics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LiyUcJ via IFTTT
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
American Journal of Human Genetics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o5fDa3 via IFTTT
Cyanate as energy source for nitrifiers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
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Wound-healing factors can prime head and neck cancer cells to increase their tumor-forming capacity
Wound-healing factors can prime head and neck cancer cells to increase their tumor-forming capacity: Objectives/Hypothesis We investigated whether exposing a wound-healing-sensitive cell line to human wound fluid (HWF) could prime the cells to increase their tumor-forming ability in nude mice and, if so, whether this ability can be inhibited by pharmacological substances. Study Design Experimental animal model. Methods Take rate was measured in BALB/c nude mice after pretreatment of the cells with HWF using human serum and fetal bovine serum as controls. Inhibition of signal transdu... περισσότερα »
Dizziness and death: An imbalance in mortality
Dizziness and death: An imbalance in mortality: Objectives/Hypothesis To determine if dizziness is an independent risk factor for mortality among adults in the United States. Study Design Cross-sectional analysis using the National Health Interview Survey (NHIS). Methods Adult respondents in the 2008 NHIS were evaluated. Demographic information (gender, race, ethnicity, education level), prevalence of dizziness, mortality rates, and leading causes of death (cardiovascular disease, cancer, diabetes, cerebrovascular disease) were collected and analyzed. The association between dizzines... περισσότερα »
Does total intravenous anesthesia provide significant blood loss reduction compared to inhalational anesthesia during endoscopic sinus surgery?
Does total intravenous anesthesia provide significant blood loss reduction compared to inhalational anesthesia during endoscopic sinus surgery?: Level of Evidence NA *Laryngoscope*, 2015
MRI reveals the complementary effects of decongestant and Breathe Right Nasal Strips on internal nasal anatomy
Magnetic resonance imaging reveals the complementary effects of decongestant and Breathe Right Nasal Strips on internal nasal anatomy: Objectives/Hypothesis This magnetic resonance imaging (MRI) study of 26 subjects with nasal congestion was performed to assess in the complete nasal passage both the anatomical effect of the marketed Breathe Right Nasal Strip (BRNS) relative to placebo and the potential adjunctive effect of using a decongestant in combination with the BRNS. Study Design Randomized, crossover study. Methods The study consisted of two parts, the first involving applicat... περισσότερα »
Evolution of postirradiated sudden deafness in nasopharyngeal carcinoma survivors during the past two decades
Evolution of postirradiated sudden deafness in nasopharyngeal carcinoma survivors during the past two decades: Objective/Hypothesis The beneficial effect of intensity-modulated radiotherapy (IMRT) on reducing the prevalence of postirradiated sudden deafness (PISD) in nasopharyngeal carcinoma (NPC) survivors has never been mentioned. This study investigated the evolution of PISD in NPC survivors during the past two decades. Study Design Retrospective study. Methods Of the 3,206 NPC patients who underwent radiotherapy during the past two decades, 32 patients (34 ears) had PISD. Twenty... περισσότερα »
Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: A systematic review
Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: A systematic review: Objectives/Hypothesis Dysphagia is still a treatment-related morbidity, despite advances in treatment modalities for oral and oropharyngeal squamous cell carcinoma. This systematic review aimed to analyze the effects of swallowing outcomes of patients with oral or oropharyngeal squamous cell carcinoma treated with primary surgery with primary free flap reconstruction, with or without adjuvant therapy, for patients un... περισσότερα »
Vestibular pathology in children with enlarged vestibular aqueduct
Vestibular pathology in children with enlarged vestibular aqueduct: Objectives/Hypothesis To establish the prevalence of abnormal vestibular test findings in children with enlarged vestibular aqueduct (EVA) and determine if these findings correlate with clinical symptoms, radiographic findings (EVA size and laterality), audiometric findings, and genetic testing in these patients. Study Design Prospective cohort. Methods Patients 3 to 12 years of age with hearing loss and imaging findings consistent with EVA treated at our tertiary care institution were sequentially enrolled from 200... περισσότερα »
Prognostic value of albumin in patients with head and neck cancer
Prognostic value of albumin in patients with head and neck cancer: Objectives/Hypothesis Albumin is an indicator of nutritional status and has been investigated as a predictor of cancer survival and perioperative outcomes. This study investigated the prognostic value of preoperative serum albumin in surgical patients with head and neck cancer (HNC). Study Design Retrospective cohort study. Methods A chart review was performed of patients who underwent HNC resection over a 6-year period at a single institution. Statistical analyses including Cox proportional hazards models, Pearson's ... περισσότερα »
Fanconi anemia patients with head and neck cancer
In response to Natural history and management of fanconi anemia patients with head and neck cancer: A 10-year follow-up:
The effect of acupuncture on postoperative nausea and vomiting after pediatric tonsillectomy: A meta-analysis and systematic review
The effect of acupuncture on postoperative nausea and vomiting after pediatric tonsillectomy: A meta-analysis and systematic review: Objectives/Hypothesis Tonsillectomy is one of the most frequently performed pediatric surgical procedures worldwide. The complications of this procedure include postoperative nausea and vomiting (PONV) and pain; therefore, both the treatment and prevention of PONV are important. Classical antiemetics include drug therapies such as ondansetron, which are undesirable because they often carry a high cost and several side effects. Therefore, in this study... περισσότερα »
Snoring intensity and excessive daytime sleepiness in subjects without obstructive sleep apnea
Snoring intensity and excessive daytime sleepiness in subjects without obstructive sleep apnea: Objectives/Hypothesis Snoring and excessive daytime sleepiness (EDS) are major obstructive sleep apnea (OSA) symptoms. Snorers with apnea/hypopnea index < 5 are designated “simple snorers” and do not meet OSA criteria. This study aimed to explore a possible association between snoring intensity and EDS defined as Epworth Sleepiness Scale (ESS) scores ≥ 11 in non-OSA subjects. Study Design Prospective cohort study. Methods From a total of 2,225 subjects who underwent polysomnography (PSG), ... περισσότερα »
Patterns of regional and distant metastasis in esthesioneuroblastoma
Patterns of regional and distant metastasis in esthesioneuroblastoma: Objectives/Hypothesis To define the incidence and risk factors of metastatic disease and the effectiveness of salvage therapy in esthesioneuroblastoma (ENB). Study Design Retrospective analysis of 57 patients presenting from 1979 through 2009. Methods Cumulative incidence of neck failure, distant failure, and survival were assessed using the Kaplan-Meier method. Results Overall survival for all patients was 85% at 5 years and 75% at 10 years. Overall survival was negatively impacted by intracranial tumor extension ( ... περισσότερα »
Bone-anchored hearing aid and skin graft removal with subsequent cochlear implantation
Bone-anchored hearing aid and skin graft removal with subsequent cochlear implantation: We describe a novel technique of scalp flap rearrangement for cochlear implant (CI) candidates who have previously undergone ipsilateral bone-anchored hearing aid (BAHA) placement. One patient with single-sided deafness (SSD) underwent removal of a BAHA with subsequent scalp rearrangement for coverage of the implant site. After adequate healing of the scalp rotational flap, he underwent uncomplicated cochlear implantation without soft tissue complications. With increasing utilization of CIs in ... περισσότερα »
Inferior alveolar nerve hemangioma
Inferior alveolar nerve hemangioma: A 14-year-old male presented with lower lip numbness and a slowly enlarging mandibular mass. Computed tomography demonstrated an expansile lesion centered in the marrow space of the left mandibular body, extending along the course of the inferior alveolar nerve (IAN), and expanding the mental foramen. Preoperative diagnosis was consistent with an IAN schwannoma. Surgical planning was performed using PROPLAN CMF software. The lesion was approached via a sagittal split osteotomy and excised en bloc with the IAN. Final pathology demonstrated a capil... περισσότερα »
Infrared videoangiographic assessment of cochlear nerve vasculature during middle fossa surgery
Infrared videoangiographic assessment of cochlear nerve vasculature during middle fossa surgery:
Incus footplate assembly: Indication and surgical outcome
Incus footplate assembly: Indication and surgical outcome: Objectives/Hypothesis To review surgical findings and hearing outcomes of incus footplate assembly (IFA) for the patients with conductive hearing loss due to missing stapes superstructure with a mobile stapes footplate. Study Design Retrospective case review and survey. Methods Pre- and postoperative audiometric data and intraoperative findings were reviewed. Postoperative air-bone gap (ABG) and ABG closure (postoperative air-conduction threshold–preoperative bone-conduction threshold) were analyzed. Results The causes of mis... περισσότερα »
A Retrospective 3D Radiologic Analysis of 52 Patients with Mandible Fractures
A Retrospective 3D Radiologic Analysis of 52 Patients with Mandible Fractures: Facial plast Surg 2016; 32: 105-110 DOI: 10.1055/s-0036-1571350 When fractured, mandible angulates. For better preoperative evaluation, movements of fractured mandibular segments should be documented in x-, y-, and z-axes. This article quantitatively evaluates the pattern and degree of the angulation. Fifty-two patients with mandible fractures were involved in this study. After defining a three-dimensional (3D) coordination system consisting of the x-axis (the axis directed from the medial to lateral sid... περισσότερα »
Spare Roof Technique: A Middle Third New Technique
Spare Roof Technique: A Middle Third New Technique: Facial plast Surg 2016; 32: 111-116 DOI: 10.1055/s-0035-1570503 To our knowledge, the spare roof technique (SRT) is the first technique that is based on a complete skeletonization/preservation of the upper lateral cartilages. This technique is used to keep the natural roof of the nose's middle third, while dehumping and/or correcting the crooked septum. From January 2014 till March 2015, a total of 40 rhinoplasties were performed through the SRT: 28 reduction rhinoplasties, 6 complex crooked noses (with extracorporeal septoplasty)... περισσότερα »
Form and Function of the Nasal Tip: Reorienting and Reshaping the Lateral Crus
Form and Function of the Nasal Tip: Reorienting and Reshaping the Lateral Crus: Facial plast Surg 2016; 32: 049-058 DOI: 10.1055/s-0035-1570504 Dysfunction of the external nasal valve affects both the form and function of the nose. Successful treatment of these problems is dependent on proper analysis and diagnosis of the aberrant anatomy. Cephalic malpositioning of the lateral crura has been described for nearly 30 years. Repositioning of the lateral crura in a more caudal orientation with lateral crural strut grafts will correct aesthetic abnormalities and reinforce the external ... περισσότερα »
An Economical Approach to Ethnic Asian Rhinoplasty
An Economical Approach to Ethnic Asian Rhinoplasty: Facial plast Surg 2016; 32: 095-104 DOI: 10.1055/s-0036-1571349 Septal cartilage is deficient in Asians seeking augmentation rhinoplasty. Economized utilization of resources is necessary for durable tip enhancement that complements a dorsal implant. We introduce a modified tongue-in-groove method designed to transmit forces across the dorsum, eliminating the need for robust caudal support and prioritizing nasal lengthening and tip projection. We aim to promote the roundness index parameter and demonstrate the feasibility of a nove... περισσότερα »
The Conchal Cartilage Butterfly Graft
The Conchal Cartilage Butterfly Graft: Facial plast Surg 2016; 32: 042-048 DOI: 10.1055/s-0035-1570326 Nasal obstruction due to weakening of the nasal sidewall is a very common patient complaint. The conchal cartilage butterfly graft is a proven technique for the correction of nasal valve collapse. It allows for excellent functional results, and with experience and attention to technical detail, it may also provide excellent cosmetic results. While this procedure is most useful for restoring form and function in cases of secondary rhinoplasty following the reduction of nasal suppor... περισσότερα »
Evolution of Preoperative Rhinoplasty Consult by Computer Imaging
Evolution of Preoperative Rhinoplasty Consult by Computer Imaging: Facial plast Surg 2016; 32: 080-087 DOI: 10.1055/s-0035-1570125 The preoperative consultation in rhinoplasty involves a multitude of actions that are mandatory for the decision-making process: history taking with attention to the symptoms and specific requests of the patient, clinical evaluation of the aesthetics, the functional status of the nose and the patients' motivation for surgery, and acquisition of standardized preoperative photographs. During the last decade, computer imaging or morphing of the preoperativ... περισσότερα »
The Autospreader Flap for Midvault Reconstruction following Dorsal Hump Resection
The Autospreader Flap for Midvault Reconstruction following Dorsal Hump Resection: Facial plast Surg 2016; 32: 036-041 DOI: 10.1055/s-0035-1570324 Dorsal hump reduction without adequate reconstitution of the midvault can often result in cosmetic or functional problems. One of the simplest techniques to avoid these problems is the use of the excess upper lateral cartilage to reconstruct the midvault (the spreader flap or autospreader). Herein we outline the history of the technique and present the specific indications and contraindications, as well as describe our method for achiev... περισσότερα »
Mitek Suspension of the Lateral Nasal Wall
Mitek Suspension of the Lateral Nasal Wall: Facial plast Surg 2016; 32: 070-075 DOI: 10.1055/s-0035-1570124 The nasal valve has long been described as the anatomical boundary most likely to inhibit nasal airflow and lead to subsequent nasal obstruction. Although many procedures can address this area to improve the nasal airway, for over 20 years, suture lateralization of the external nasal valve has been described as a minimally invasive technique that can improve nasal breathing. We report our modification of the standard technique in which we lateralize the placement of the bone-... περισσότερα »
Three-Dimensional Surface Imaging and the Continuous Evolution of Preoperative and Postoperative Assessment in Rhinoplasty
Three-Dimensional Surface Imaging and the Continuous Evolution of Preoperative and Postoperative Assessment in Rhinoplasty: Facial plast Surg 2016; 32: 088-094 DOI: 10.1055/s-0035-1570122 During the preoperative assessment in rhinoplasty, the surgeon takes a thorough history, performs a complete examination by assessing functional and aesthetic aspects of the nose, obtains a clear understanding of the patient's wishes, conducts facial analysis based on standardized photography, and communicates to the patient the goals and pitfalls of surgery. Computer imaging or morphing of the pr... περισσότερα »
Regional and distant metastasis in esthesioneuroblastoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Patterns of regional and distant metastasis in esthesioneuroblastoma: Objectives/Hypothesis To define the incidence and risk factors of metastatic disease and the effectiveness of salvage therapy in esthesioneuroblastoma (ENB). Study Design Retrospective analysis of 57 patients presenting from 1979 through 2009. Methods Cumulative incidence of neck failure, distant failure, and survival were assessed using the Kaplan-Meier method. Results Overall survival for all patients was 85% at 5 years and 75% at 10 years. Overall survival was negatively impacted by intracranial tumor extension ( ... περισσότερα »
Evaluation of the Patient with Nasal Obstruction
Evaluation of the Patient with Nasal Obstruction: Facial plast Surg 2016; 32: 003-008 DOI: 10.1055/s-0035-1570502 Nasal obstruction is often multifactorial and knowledge of the contributing factors is critical to appropriate evaluation, diagnosis, and execution of a treatment plan. Recognizing and appropriately managing all components of nasal obstruction will increase the likelihood of symptomatic improvement and patient satisfaction. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Abstract | Full te... περισσότερα »
Spreader Grafts in Functional Rhinoplasty
Spreader Grafts in Functional Rhinoplasty: Facial plast Surg 2016; 32: 029-035 DOI: 10.1055/s-0035-1570127 Management of the middle vault is paramount to achieving optimal aesthetic and functional outcomes in rhinoplasty. The ideal treatment for middle vault complications, such as internal nasal valve collapse, inverted-V deformity, and middle vault dorsal asymmetry, is prevention. Risk factors for middle vault problems in rhinoplasty that may be identified in preoperative consultation include short nasal bones, long and weak upper lateral cartilages, thin skin, previous trauma or ... περισσότερα »
Migrated Implant Causing Refractory Headache in Rhinoplasty
Migrated Implant Causing Refractory Headache in Rhinoplasty: Facial plast Surg 2016; 32: 117-120 DOI: 10.1055/s-0035-1570121 Alloplastic materials are popular and readily available for use in nasal augmentations. Among them, silicone implant is one of the most widely used, especially in certain areas in Asia for its reasonable cost and relatively simple operative technique. A major disadvantage of silicone is its notorious mobility after implantation and rate of extrusion if traumatized or exposed. Here, an unusual complication of a silicone implant for rhinoplasty was presented. W... περισσότερα »
Extracorporeal Septoplasty: External and Endonasal Techniques
Extracorporeal Septoplasty: External and Endonasal Techniques: Facial plast Surg 2016; 32: 022-028 DOI: 10.1055/s-0035-1570123 Severe septal deformities are among the most challenging problems faced by rhinoplasty surgeons. Extracorporeal septoplasty (ES)—also known as subtotal septal reconstruction—involves removal of the native deformed septum and replacement with a reconstructed neoseptum. Several techniques and multiple variations have been described in the literature. We present an overview of ES, pertinent anatomical structures and deformities, and the external versus endona... περισσότερα »
The Nasal Airway: A Critical Review
The Nasal Airway: A Critical Review: Facial plast Surg 2016; 32: 017-021 DOI: 10.1055/s-0035-1570323 Functional nasal surgery is frequently performed and deeply embedded in otolaryngology. However, unequivocal proof of its efficacy is still pending, leading some health authorities toward restrictive policies. In this article, we review the evidence and suggest that reexamining the paradigm of functional nasal surgery may be appropriate. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Abstract | Full t... περισσότερα »
Rhinoplasty of the Aging Nose
Rhinoplasty of the Aging Nose: Facial plast Surg 2016; 32: 059-069 DOI: 10.1055/s-0035-1570126 The process of aging leads to countless bodily changes on both a macro- and microscopic scale. No organ system is unaffected; however, the nose is especially susceptible. Sun damage, hormone levels, regenerative capability, tissue elasticity, bone resorption, and the effects of gravity contribute to produce classic signs and symptoms. Rhinoplasty of the aging nose requires a comprehensive understanding of aging facial anatomy combined with surgical techniques designed to resist these ubiq... περισσότερα »
Does the Nose Have a Function Beyond Breathing?
Does the Nose Have a Function Beyond Breathing?: Facial plast Surg 2016; 32: 009-016 DOI: 10.1055/s-0035-1570327 This article examines how functional nasal surgery can result in aesthetic improvement to the nose. We performed a literature search examining functional rhinoplasty with resultant aesthetic benefits. We also conducted a review of various techniques that can be used to correct functional nasal obstruction that also achieve aesthetic improvement(s).Although there are data demonstrating improvements to quality of life after functional and aesthetic nasal surgery, there is ... περισσότερα »
Causes and Prevention of Secondary Obstruction
Causes and Prevention of Secondary Obstruction: Facial plast Surg 2016; 32: 076-079 DOI: 10.1055/s-0035-1570325 Secondary nasal obstruction occurs when surgery fails to improve a patient's nasal obstruction symptoms. This may occur from failure to recognize a problem preoperatively or failure to address mucocutaneous medical ailments. Secondary obstruction may even occur despite perfect execution of the operative plan. In this article, we discuss the etiology, intraoperative pitfalls, and surgical correction of secondary obstruction after primary rhinoplasty. When managing postrhin... περισσότερα »
Breathing difficulty
Remain calm: Assessing and treating panic attacks: Some patient encounters are keepers; other experiences need to be forgotten. Overcoming past calls is one of those skills that nobody teaches you in EMT school. Exorcising the demons that build as the days and weeks of an EMS career build is imperative. One patient complaining of the same thing as another are two entirely different people with potentially two entirely different medical problems. Of course, the chance always exists that there is actually no problem at all, and therein lies the problem. Bringing the memory of one cal... περισσότερα »
Oxidative balance in euthyroid Hashimoto's thyroiditis (HT)
OXIDATIVE STRESS AND ADVANCED GLYCATION END PRODUCTS (AGEs) IN HASHIMOTO'S THYROIDITIS Thyroid. 2016 Feb 8; Authors: Ruggeri RM, Vicchio TM, Cristani M, Certo R, Caccamo D, Alibrandi A, Giovinazzo S, Saija A, Campenni A, Trimarchi F, Gangemi S Abstract BACKGROUND: Oxidative stress, which occurs as a result of an imbalance between free radicals production and antioxidant defense mechanisms, has been implicated in the pathogenesis of several autoimmune disorders, including thyroid diseases. Mainly, it has been correlated to thyroid dysfunction. METHODS: Aim of our study was to inve... περισσότερα »
The metastasis of papillary thyroid carcinoma to the parapharyngeal space
*CASE REPORT* A thyroid tumor extending to the parapharyngeal space *- Fikret CetikEmail author, - Demet YaziciEmail author and - Aysun Uguz* *BMC Ear, Nose and Throat DisordersDOI: 10.1186/1472-6815-6-3* Abstract Background *The metastasis of papillary thyroid carcinoma to the parapharyngeal space is rare and discussed in the English literature before. Encountering a parapharyngeal mass with cystic appearance on imaging, one should rule out thyroid malignancy as differential diagnosis.* Case presentation *The case presented here is a 22-year-old woman who was referred to our cli... περισσότερα »
Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data
Genome-wide association studies (GWAS) have associated many single variants with complex disease, yet the better part heritable complex disease risk remains unexplained. Analytical tools designed to work under specific population genetic models are needed. Rare variants are increasingly shown to be important in human complex disease, but most existing GWAS data do not cover rare variants. Explicit population genetic models predict that genes contributing to complex traits and experiencing recurrent, unconditionally-deleterious mutation will harbor multiple rare, causative mutation... περισσότερα »
Objective and Subjective Outcome of a New Transcutaneous Bone Conduction Hearing Device: Half-year Follow-up of the First 12 Nordic Implantations.
Objective: To examine the objective and subjective outcome of a new transcutaneous bone conduction hearing device. Study Design: Prospective, consecutive case series. Patients: Twelve patients were implanted. Eight patients had a conductive/mixed (con/mix) hearing loss. Four had single sided deafness. Main Outcome Measures: At half-year follow-up, aided and unaided sound field hearing was evaluated by 1) warble tone thresholds, 2) pure-tone average (PTA4), 3) speech discrimination score (SDS) in quiet, and 4) speech reception threshold 50% at 70 dB SPL noise level (SRT50%). Subjecti... περισσότερα »
Statistical Reasoning and Methods in Epidemiology to Promote Individualized Health: In Celebration of the 100th Anniversary of the Johns Hopkins University Bloomberg School of Public Health
Epidemiology is concerned with determining the distribution and causes of disease. Throughout its history, epidemiology has drawn upon statistical ideas and methods to achieve its aims. Because of the exponential growth in our capacity to measure and analyze data on the underlying processes that define each person's state of health, there is an emerging opportunity for population-based epidemiologic studies to influence health decisions made by individuals in ways that take into account the individuals' characteristics, circumstances, and preferences. We refer to this endeavor as ... περισσότερα »
Epidemiology and the Tobacco Epidemic: How Research on Tobacco and Health Shaped Epidemiology
In this article, I provide a perspective on the tobacco epidemic and epidemiology, describing the impact of the tobacco-caused disease epidemic on the field of epidemiology. Although there is an enormous body of epidemiologic evidence on the associations of smoking with health, little systematic attention has been given to how decades of research have affected epidemiology and its practice. I address the many advances that resulted from epidemiologic research on smoking and health, such as demonstration of the utility of observational designs and important parameters (the odds rat... περισσότερα »
Meta-Analysis With a Continuous Covariate That Is Differentially Categorized Across Studies
We propose taking advantage of methodology for missing data to estimate relationships and adjust outcomes in a meta-analysis where a continuous covariate is differentially categorized across studies. The proposed method incorporates all available data in an implementation of the expectation-maximization algorithm. We use simulations to demonstrate that the proposed method eliminates bias that would arise by ignoring a covariate and generalizes the meta-analytical approach for incorporating covariates that are not uniformly categorized. The proposed method is illustrated in an appl... περισσότερα »
68Gallium-DOTATATE PET in meningioma: A reliable predictor of tumor growth rate?
Background DOTATATE-based radionuclides have added new options in the diagnosis and treatment of meningiomas; however, a reliable predictor of tumor growth has still not been established. Methods We analyzed 64 meningiomas imaged with 68Ga-DOTATATE PET. Tumor growth rates were calculated by volumetric analysis of sequential MRI scans. Maximums of standardized uptake values (SUVmax) were correlated with tumor growth and covariates. Results World Health Organization (WHO) grades I and II meningiomas showed a correlation of SUVmax and tumor growth rate (meningiomas limited to the... περισσότερα »
Re: A simplified approach to reconstruction of hemipelvectomy defects with lower extremity free fillet flaps to minimize ischaemia time
Publication date: Available online 10 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): B. Strong, M. Ragbir from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T9m5Ii via IFTTT
Fat grafting & the philosopher's stone
Publication date: February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery, Volume 69, Issue 2 Author(s): Roger K. Khouri, Thomas M. Biggs from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Q8GKHa via IFTTT
A PROM primer
Publication date: February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery, Volume 69, Issue 2 Author(s): M. Felix Freshwater from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Q8GHLx via IFTTT
A PROM primer
Ask a typical American high school girl, "What is a prom"? She will tell you that it is the final social event of high school life which is what some in the UK call a "leaver's ball". Ask the average American hand therapist to define the acronym PROM and she will tell you that it represents passive range of motion, in contrast to AROM or active range of motion. In fact, PROM also stands for Patient Reported Outcome Measures. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1O3WQka via IFTTT
Fat grafting & the philosopher's stone
2014 and 2015 saw a surge of review articles evaluating various fat processing techniques, all of which concluded that no specific technique significantly effects fat graft survival.1–7 Surgeons continue to look for the perfect recipe that would allow for 100% graft survival. This pursuit of the "philosopher's stone" of fat grafting dates back to a 2012 review article urging researchers to continue the magnum opus.8 Similar to the alchemists' search, this great work has no end in sight. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/20MXejm via IFTTT
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?: Abstract Background Total thyroidectomy is a well-established surgical approach for the management of papillary thyroid cancer (PTC). However, the best surgical approach for papillary microcarcinoma is nowadays still debated. Both total thyroidectomy and simple lobectomy are used. We report the experience of a single… Continue reading Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?
Single-Case Design Research: Building the Evidence-Base in the Field of Education of Deaf and Hard of Hearing Students.
Authors: Cannon JE, Guardino C, Antia SD, Luckner JL Abstract The field of education of deaf and hard of hearing (DHH) students has a paucity of evidence-based practices (EBPs) to guide instruction. The authors discussed how the research methodology of single-case design (SCD) can be used to build EBPs through direct and systematic replication of… Continue reading Single-Case Design Research: Building the Evidence-Base in the Field of Education of Deaf and Hard of Hearing Students.
Exposure to PBDEs and thyroid hormone levels
EXPOSURE TO POLYBROMINATED DIPHENYL ETHERS ASSOCIATES WITH HYPOTHYROIDISM: EXPOSURE TO POLYBROMINATED DIPHENYL ETHERS ASSOCIATES WITH HYPOTHYROIDISM *Oulhote Y1, Chevrier J1, Bouchard MF Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women.* J Clin Endocrinol Metab. 2016 Feb;101(2):590-8. doi: 10.1210/jc.2015-2659. Epub 2015 Nov 25. Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyr... περισσότερα »
Dynamic Range Across Music Genres and the Perception of Dynamic Compression in Hearing-Impaired Listeners
Dynamic range compression serves different purposes in the music and hearing-aid industries. In the music industry, it is used to make music louder and more attractive to normal-hearing listeners. In the hearing-aid industry, it is used to map the variable dynamic range of acoustic signals to the reduced dynamic range of hearing-impaired listeners. Hence, hearing-aided listeners will typically receive a dual dose of compression when listening to recorded music. The present study involved an acoustic analysis of dynamic range across a cross section of recorded music as well as a pe... περισσότερα »
Dynamic Range Across Music Genres and the Perception of Dynamic Compression in Hearing-Impaired Listeners
Dynamic range compression serves different purposes in the music and hearing-aid industries. In the music industry, it is used to make music louder and more attractive to normal-hearing listeners. In the hearing-aid industry, it is used to map the variable dynamic range of acoustic signals to the reduced dynamic range of hearing-impaired listeners. Hence, hearing-aided listeners will typically receive a dual dose of compression when listening to recorded music. The present study involved an acoustic analysis of dynamic range across a cross section of recorded music as well as a pe... περισσότερα »
Thyroid gland subpopulations.
Cell growth dynamics in embryonic and adult mouse thyroid revealed by a novel approach to detect thyroid gland subpopulations Thyroid. 2016 Feb 8; Authors: Gawade S, Mayer CE, Hafen K, Barthlott T, Krenger W, Szinnai G Abstract BACKGROUND: The thyroid is composed of endocrine epithelial cells, blood vessels and mesenchyme. However, no data exist thus far on absolute cell numbers, relative distribution, and proliferation of the different cell populations in the developing and mature thyroid. The aim of this study was therefore to establish a flow cytometry protocol that allows detec... περισσότερα »
Oxidants are increased and antioxidants decreased in euthyroid HT patients; as a result, the oxidative/anti-oxidative balance is shifted towards the oxidative side. Moreover, we first report on a possible significant involvement of AGEs in HT, thus contributing to a better definition of the redox homoeostasis dysregulation in HT.
OXIDATIVE STRESS AND ADVANCED GLYCATION END PRODUCTS (AGEs) IN HASHIMOTO'S THYROIDITIS Thyroid. 2016 Feb 8; Authors: Ruggeri RM, Vicchio TM, Cristani M, Certo R, Caccamo D, Alibrandi A, Giovinazzo S, Saija A, Campenni A, Trimarchi F, Gangemi S Abstract BACKGROUND: Oxidative stress, which occurs as a result of an imbalance between free radicals production and antioxidant defense mechanisms, has been implicated in the pathogenesis of several autoimmune disorders, including thyroid diseases. Mainly, it has been correlated to thyroid dysfunction. METHODS: Aim of our study was to inve... περισσότερα »
Pediatric Differentiated Thyroid Carcinoma of Follicular Cell Origin
Pediatric Differentiated Thyroid Carcinoma of Follicular Cell Origin: Prognostic Significance of Histologic Subtypes Thyroid. 2016 Feb;26(2):219-226 Authors: Balachandar S, La Quaglia M, Tuttle RM, Heller G, Ghossein RA, Sklar CA Abstract BACKGROUND: Thyroid cancers are rare in the pediatric age group, and unlike in adults, few data are available regarding the clinical implication of histologic subtypes in the pediatric population. The purpose of the current study was to determine the prognostic significance of histologic subtypes of differentiated thyroid cancer (DTC) in a large ... περισσότερα »
Pediatric Differentiated Thyroid Carcinoma of Follicular Cell Origin: Prognostic Significance of Histologic Subtypes.
Pediatric Differentiated Thyroid Carcinoma of Follicular Cell Origin: Prognostic Significance of Histologic Subtypes.: *Pediatric Differentiated Thyroid Carcinoma of Follicular Cell Origin: Prognostic Significance of Histologic Subtypes.* Thyroid. 2016 Feb;26(2):219-226 Authors: Balachandar S, La Quaglia M, Tuttle RM, Heller G, Ghossein RA, Sklar CA Abstract BACKGROUND: Thyroid cancers are rare in the pediatric age group, and unlike in adults, few data are available regarding the clinical implication of histologic subtypes in the pediatric population. The purpose of the current ... περισσότερα »
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation: Abstract BackgroundMutations in the *TERT* promoter, *ALK* rearrangement, and the *BRAF* V600E mutation are associated with aggressive clinicopathologic features in thyroid cancers. However, little is known about the impact of *TERT* promoter mutations and *ALK* rearrangement in thyroid cancer patients with a high prevalence of *BRAF* mutations. MethodsWe performed Sanger sequencing to detect *BRA*F V600E and *TERT* promoter mutations a... περισσότερα »
A Calcitonin Non-producing Neuroendocrine Tumor of the Thyroid Gland
A Calcitonin Non-producing Neuroendocrine Tumor of the Thyroid Gland: AbstractNeuroendocrine tumors of the thyroid gland are generally considered to derive from parafollicular endocrine cells (C cells) and are generally referred to as medullary thyroid carcinomas (MTC). Calcitonin secretion is almost always detected in MTC and a prerequisite for both clinical and pathological diagnosis. Thyroid neuroendocrine tumors without any apparent calcitonin secretion reflect a diagnostic dilemma because non-calcitonin-producing MTCs have virtually not been characterized. Here, we report a ca... περισσότερα »
Primary squamous cell of the thyroid
Primary squamous cell of the thyroid–an abbreviated clinical presentation Justin T Lui, Moosa N Khalil and Shamir P ChandaranaEmail author Journal of Otolaryngology - Head & Neck Surgery201443:17 DOI: 10.1186/1916-0216-43-17© Lui et al.; licensee BioMed Central Ltd. 2014 Received: 7 December 2013Accepted: 11 June 2014Published: 18 June 2014 Abstract Background Lacking any squamous epithelium, thyroid gland with primary squamous cell carcinoma (PSCC) proves to be an etiopathophysiological quandary. Two major theories do exist, though few cases have been documented to support... περισσότερα »
T-screen and yeast assay for the detection of the thyroid-disrupting activities of cadmium, mercury, and zinc
T-screen and yeast assay for the detection of the thyroid-disrupting activities of cadmium, mercury, and zinc: AbstractIn the present study, a two-hybrid yeast bioassay and a T-screen were used to screen for the thyroid receptor (TR)-disrupting activity of select metallic compounds (CdCl2, ZnCl2, HgCl2, CuSO4, MnSO4, and MgSO4). The results reveal that none of the tested metallic compounds showed TR-agonistic activity, whereas ZnCl2, HgCl2, and CdCl2 demonstrated TR antagonism. For the yeast assay, the dose–response relationship of these metallic compounds was established, and the ... περισσότερα »
Excess iodide downregulates Na+/I− symporter gene transcription through activation of PI3K/Akt pathway
Excess iodide downregulates Na+/I− symporter gene transcription through activation of PI3K/Akt pathway via http://rss.sciencedirect.com/publication/science/03037207 Publication date: Available online 9 February 2016 *Source:*Molecular and Cellular Endocrinology Author(s): Caroline Serrano-Nascimento, Juan Pablo Nicola, Silvania da Silva Teixeira, Leonice Lourenço Poyares, Camilo Lellis-Santos, Silvana Bordin, Ana Maria Masini-Repiso, Maria Tereza Nunes Transcriptional mechanisms associated with iodide-induced downregulation of NIS expression remain uncertain. Here, we further analyzed t... περισσότερα »
Natural History of Asymptomatic Papillary Thyroid Microcarcinoma: Time-Dependent Changes in Calcification and Vascularity During Active Surveillance
Natural History of Asymptomatic Papillary Thyroid Microcarcinoma: Time-Dependent Changes in Calcification and Vascularity During Active Surveillance: Abstract BackgroundProspective trials of non-surgical observation have shown progression rates of only 5–10 % in patients with asymptomatic papillary microcarcinoma (PMC). This study investigated time-dependent changes in calcification patterns and tumor vascularity on ultrasonography (US) to clarify the natural course of PMC. MethodsWe examined calcification patterns and tumor vascularity for 480 lesions in 384 patients. Calcific... περισσότερα »
Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves’ Disease
Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves’ Disease: Abstract BackgroundTo reduce intraoperative and postoperative complications, using Lugol solution to preoperatively prepare patients with Graves’ disease has (1) rapidly reduced the severity of thyrotoxicosis and (2) reduced the vascularity of the thyroid gland. The vascularity reduction normally accompanies reducing the severity of thyrotoxicosis. However, the effects and mechanism of Lugol solution for reducing blood flow have not been well inves... περισσότερα »
Bilateral Axillo-Breast Approach Robotic Thyroidectomy with Open Thyroidectomy for Graves’ Disease
Comparison of Bilateral Axillo-Breast Approach Robotic Thyroidectomy with Open Thyroidectomy for Graves’ Disease: Abstract BackgroundThere is an ongoing debate about whether robotic thyroidectomy (RT) is appropriate for Graves’ disease. The aim of this study was to compare the safety of bilateral axillo-breast approach (BABA) RT with that of open thyroidectomy (OT) in patients with Graves’ disease. MethodsFrom January 2008 to June 2014, 189 (44 BABA RT and 145 OT) patients underwent total thyroidectomy for Graves’ disease. Recurrence of Graves’ disease, intraoperative blood los... περισσότερα »
Prognosis After Brain Metastasis from Differentiated Thyroid Carcinoma
Prognosis After Brain Metastasis from Differentiated Thyroid Carcinoma: Abstract BackgroundIn patients with differentiated thyroid carcinoma (DTC), lung and bone metastasis sometimes occur. However, brain metastasis (BM) is extremely rare. Because most previous reports about BM from DTC included a relatively small number of cases, the clinical characteristics and outcomes of BM are still unclear. Patients and methodsBetween 1965 and 2013, among 961 patients who had died because of DTC, 24 patients were diagnosed with BM from DTC. One patient with BM from DTC is still alive. To i... περισσότερα »
Safety of Continuous Intraoperative Neuromonitoring (C-IONM) in Thyroid Surgery
Safety of Continuous Intraoperative Neuromonitoring (C-IONM) in Thyroid Surgery:
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?: Abstract BackgroundTotal thyroidectomy is a well-established surgical approach for the management of papillary thyroid cancer (PTC). However, the best surgical approach for papillary microcarcinoma is nowadays still debated. Both total thyroidectomy and simple lobectomy are used. We report the experience of a single University center in the treatment of thyroid microcarcinoma. MethodsA retrospective analysis on all patients who underwent thyroid surgery at our institution ... περισσότερα »
Die Bedeutung der Sonografie bei der Abklärung von Schilddrüsenerkrankungen
Die Bedeutung der Sonografie bei der Abklärung von Schilddrüsenerkrankungen: Laryngo-Rhino-Otol 2016; 95: 87-104 DOI: 10.1055/s-0041-111275 Schilddrüsenknoten und Schilddrüsenveränderungen sind häufige Befunde in der Allgemeinbevölkerung. Die Sonografie ist dabei das wichtigste bildgebende Instrument der Schilddrüsendiagnostik. In Zusammenschau des sonografischen Befunds mit basalen Schilddrüsenhormonparametern und dem klinischen Bild lässt sich in der überwiegenden Zahl der Fälle bereits eine korrekte Diagnose stellen – wie z. B. Hashimoto-Thyreoiditis, eine diffuse Struma oder ... περισσότερα »
Recurrent Laryngeal Nerve Liberations and Reconstructions
Recurrent Laryngeal Nerve Liberations and Reconstructions: A Single Institution Experience: Abstract BackgroundRecurrent laryngeal nerve (RLN) palsy rates vary from 0.5 to 10 %, even 20 % in thyroid cancer surgery. The aim of this paper was to present our experience with RLN liberations and reconstructions after various mechanisms of injury. MethodsPatients were treated in our institution from year 2000 to 2015. First group (27 patients) had large benign goiters, locally advanced thyroid/parathyroid carcinomas, or incomplete previous surgery of malignant thyroid disease. Second... περισσότερα »
Dynamic Range Across Music Genres and the Perception of Dynamic Compression in Hearing-Impaired Listeners
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Dynamic range compression serves different purposes in the music and hearing-aid industries. In the music industry, it is used to make music louder and more attractive to normal-hearing listeners. In the hearing-aid industry, it is used to map the variable dynamic range of acoustic signals to the reduced dynamic range of hearing-impaired listeners. Hence, hearing-aided […]
Ethics, research and HIV: lessons learned: a workshop report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Assessing risk for transmission of a blood-borne pathogen requires the use of the hazard and risk model. Infection control is a system that uses a number of individual processes to eliminate or reduce the probability of a hazard occurring. Strategies employed to reduce risk should be rehearsed, used routinely, audited, reviewed, and the results shared. […]
Racial disparities in esophageal cancer survival after surgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objectives Esophageal cancer (EC) black patients have higher mortality rates than Whites. The lower rate of surgery in Blacks may explain the survival difference. We explored the Surveillance Epidemiology and End Results database to determine the impact of surgery on mortality in Blacks and Whites EC. Methods All cases of pathologically proven local and locoregional […]
Effects of Manipulation on Attributions of Causation, Free Will, and Moral Responsibility
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract If someone brings about an outcome without intending to, is she causally and morally responsible for it? What if she acts intentionally, but as the result of manipulation by another agent? Previous research has shown that an agent’s mental states can affect attributions of causal and moral responsibility to that agent, but little is […]
Characteristics of cryptogenic stroke in cancer patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract Objective To clarify the characteristics of cryptogenic stroke in patients with active cancer. Methods Patients with or without cancer diagnosed with acute ischemic stroke between January 2006 and February 2015 were extracted from a prospectively collected stroke database of Osaka University Hospital. Patients were categorized according to the presence of active cancer and known […]
Hypothyroidism and hyperthyroidism and breast cancer risk: a nationwide cohort study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective The association between thyroid disease and breast cancer risk remains unclear. We, therefore examined the association between hypothyroidism, hyperthyroidism and breast cancer risk. Design This was a population-based cohort study. Methods Using nationwide registries, we identified all women in Denmark with a first-time hospital diagnosis of hypothyroidism or hyperthyroidism, 1978–2013. We estimated the excess […]
Ca2+ removal by the plasma membrane Ca2+-ATPase influences the contribution of mitochondria to activity-dependent Ca2+ dynamics in Aplysia neuroendocrine cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Following Ca2+ influx, mitochondria can sequester Ca2+ and subsequently release it back into the cytosol. This form of Ca2+-induced Ca2+-release (CICR) prolongs Ca2+ signaling and can potentially mediate activity-dependent plasticity. As Ca2+ is required for its subsequent release, Ca2+ removal systems, like the plasma membrane Ca2+ ATPase (PMCA), could impact CICR. Here, we examine such […]
Precaution for volume conduction in rodent cortical electroencephalography using high density polyimide-based micro-electrode arrays on the skull
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
In humans, significant progress has been made to link spatial changes in electroencephalographic (EEG) spectral density, connectivity strength and phase-amplitude modulation to neurological, physiological and psychological correlates. In contrast, standard rodent EEG techniques employ only few electrodes which results in poor spatial resolution. Recently a technique was developed to overcome this limitation in mice. This […]
Neuronal Responses to Tactile Stimuli and Tactile Sensations evoked by Microstimulation in the Human Thalamic Principle Somatic Sensory Nucleus – Ventral caudal
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
The normal organization and plasticity of the cutaneous core of the thalamic principal somatosensory nucleus (ventral caudal, Vc) have been studied by single neuron recordings and microstimulation in patients undergoing awake stereotactic operations for essential tremor (ET) without apparent somatic sensory abnormality, and in patients with dystonia or chronic pain secondary to major nervous system […]
Long-latency reflexes of elbow and shoulder muscles suggest reciprocal excitation of the flexors and reciprocal excitation of the extensors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Postural corrections of the upper limb are required in tasks ranging from handling an umbrella in the changing wind to securing a wriggling baby. One complication in this process is the mechanical interaction between the different segments of the arm where torque applied at one joint induces motion at multiple joints. Previous studies have shown […]
Prognosis After Brain Metastasis from Differentiated Thyroid Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Prognosis After Brain Metastasis from Differentiated Thyroid Carcinoma: Abstract BackgroundIn patients with differentiated thyroid carcinoma (DTC), lung and bone metastasis sometimes occur. However, brain metastasis (BM) is extremely rare. Because most previous reports about BM from DTC included a relatively small number of cases, the clinical characteristics and outcomes of BM are still unclear. Patients and methodsBetween 1965 and 2013, among 961 patients who had died because of DTC, 24 patients were diagnosed with BM from DTC. One patient with BM from DTC is still alive. To i... περισσότερα »
Brain Metastasis from Differentiated Thyroid Carcinoma
Prognosis After Brain Metastasis from Differentiated Thyroid Carcinoma: Abstract BackgroundIn patients with differentiated thyroid carcinoma (DTC), lung and bone metastasis sometimes occur. However, brain metastasis (BM) is extremely rare. Because most previous reports about BM from DTC included a relatively small number of cases, the clinical characteristics and outcomes of BM are still unclear. Patients and methodsBetween 1965 and 2013, among 961 patients who had died because of DTC, 24 patients were diagnosed with BM from DTC. One patient with BM from DTC is still alive. To i... περισσότερα »
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma
Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?: Abstract BackgroundTotal thyroidectomy is a well-established surgical approach for the management of papillary thyroid cancer (PTC). However, the best surgical approach for papillary microcarcinoma is nowadays still debated. Both total thyroidectomy and simple lobectomy are used. We report the experience of a single University center in the treatment of thyroid microcarcinoma. MethodsA retrospective analysis on all patients who underwent thyroid surgery at our institution o... περισσότερα »
Novel Anatomic Characteristics of the Laryngeal Framework: A Computed Tomography Evaluation
Novel Anatomic Characteristics of the Laryngeal Framework: A Computed Tomography Evaluation: Objective The thyroid cartilage (TC) in men has a more prominent thyroid notch and a narrower interlaminae angle (ILA) as compared with women. Anatomy textbooks classically stipulate that the ILA is 90° in men and 120° in women. Our observation, based on thyroid chondroplasty operations, of a much narrower angle led to the current investigation. Study Design Cohort imaging study. Setting Tertiary academic referral center. Subjects and Methods Computed tomography angiography neck images o... περισσότερα »
Radiofrequency and Ethanol Ablation for Treating Locally Recurrent Thyroid Cancer: A Systematic Review and Meta-Analysis
Efficacy and Safety of Radiofrequency and Ethanol Ablation for Treating Locally Recurrent Thyroid Cancer: A Systematic Review and Meta-Analysis: Thyroid , Vol. 0, No. 0. Author information Chong Hyun Suh,1,2 Jung Hwan Baek,1 Young Jun Choi,1 and Jeong Hyun Lee1 1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 2Department of Radiology, Namwon Medical Center, Namwon, Korea. Address correspondence to: *Jung Hwan Baek, MD, PhD* *Department of Radiology and Research Institute of Radiology* *University... περισσότερα »
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent: Thyroid , Vol. 0, No. 0. Author information Trevor E. Angell,1 Melissa G. Lechner,2 Alison M. Smith,3 Sue E. Martin,3 Susan G. Groshen,4 Dennis R. Maceri,5 Peter A. Singer,6 and Alan L. Epstein3 1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts. 2Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 3Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, Ca... περισσότερα »
Voice, speech, articulation, and quality of life in patients with head and neck cancer (HNC) treated with concurrent chemoradiotherapy (CRT)
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy via ScienceDirect Publication: Oral Oncology Publication date: Available online 10 February 2016 *Source:*Oral Oncology Author(s): S.A.C. Kraaijenga, I.M. Oskam, R.J.J.H. van Son, O. Hamming-Vrieze, F.J.M. Hilgers, M.W.M. van den Brekel, L. van der Molen ObjectivesAssessment of long-term objective and subjective voice, speech, articulation, and quality of life in patients with head and neck cancer (HNC) treated with concurrent chemoradiotherapy (CRT) for a... περισσότερα »
T3 induced cardiac hypertrophy : MuRF1 mono-ubiquitinates TR{alpha} to inhibit T3 induced cardiac hypertrophy
MuRF1 mono-ubiquitinates TR{alpha} to inhibit T3 induced cardiac hypertrophy in vivo: Thyroid hormone (T3) is classically recognized for its role in cellular metabolism and growth and participates in homeostasis of the heart. T3 activates pro-survival pathways including Akt and mTOR. Treatment with T3 following myocardial infarction is cardioprotective and promotes elements of the physiological hypertrophic response following cardiac injury. While T 3 is known to benefit the heart, very little about how it is regulated at the molecular level has been described to date. The ubiquitin... περισσότερα »
Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout
Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout: AbstractSubclinical hyperthyroidism (sHT) was found to be associated with elevated heart rate, blood pressure and increased risk of extrasystoles. However, the full clinical relevance of morphological and functional implications of sHT on the cardiovascular system is still a matter of debate. The aim of the study was to prospectively assess the influence of endogenous sHT on exercise capacity and cardiac function during workout with the use of exercise electrocardiography ... περισσότερα »
The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] ORL J Otorhinolaryngol Relat Spec. Authors: Liu J, Du J, Fan J, Liu K, Zhang B, Wang S, Wang W, Wang Z, Cai Y, Li C, Yu T, Zhu G, Chen J, Li C Abstract AIM: The aim of this study is to explore the relationship between the neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features in patients with papillary thyroid carcinoma (PTC). METHODS: We performed an analysis of 843 patients, including 321 patients with PTC, 83 patients with thyroid adenoma and 439 patients with nodular goiter (NG). Thyroglobulin and thyrotropin w... περισσότερα »
Dried Blood Spot Thyroglobulin Measurement: Field-Friendly and Ready for Field Testing.
Dried Blood Spot Thyroglobulin Measurement: Field-Friendly and Ready for Field Testing Thyroid. 2016 Feb 9; Authors: Ehrenkranz J Abstract Specimen hematocrit and ambient temperature and humidity limit the use of dried blood spots as a matrix for measuring serum proteins. PMID: 26857807 [PubMed - as supplied by publisher]
American Thyroid Association Statement on Remote Access Thyroid Surgery.
American Thyroid Association Statement on Remote Access Thyroid Surgery.: Thyroid. 2016 Feb 9; Authors: Berber E, Bernet V, Fahey T, Kebebew E, Shaha AR, Stack BC, Stang MT, Steward D, Terris DJ Abstract BACKGROUND: "Remote access techniques" have been described over the recent years to remove the thyroid gland without an incision in the neck. However, there is confusion related to the number of techniques available and the ideal patient selection criteria for a given technique. The aims of this review are to develop a simple classification of these approaches, describe the optim... περισσότερα »
Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples.
Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples Oncotarget. 2016 Feb Authors: Buj R, Mallona I, Díez-Villanueva A, Barrera V, Mauricio D, Puig-Domingo M, Reverter JL, Matias-Guiu X, Azuara D, Ramírez JL, Alonso S, Rosell R, Capellà G, Perucho M, Robledo M, Peinado MA, Jordà M Abstract Hypomethylation of DNA is a hallmark of cancer and its analysis as tumor biomarker has been proposed, but its determination in clinical settings is hampered by lack of standardized methodologies. Here, we present QUAlu (Quantification of... περισσότερα »
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus.
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus.: Authors: Lim SM, Park HS, Kim S, Kim S, Ali SM, Greenbowe JR, Yang IS, Kwon NJ, Lee JL, Ryu MH, Ahn JH, Lee J, Lee MG, Kim HS, Kim H, Kim HR, Moon YW, Chung HC, Kim JH, Kang YK, Cho BC Abstract BACKGROUND: Given the modest responses to everolimus, a mTOR inhibitor, in multiple tumor types, there is a pressing need to identify predictive biomarkers for this drug. Using targeted ultra-deep sequencing, we aimed to explore genomic alterations that confer extreme sensitivity to everoli... περισσότερα »
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.: Oncotarget. 2016 Feb. Authors: Williamson AJ, Doscas ME, Ye J, Heiden KB, Xing M, Li Y, Prinz RA, Xu X Abstract The sonic hedgehog (Shh) pathway is highly activated in thyroid neoplasms and promotes thyroid cancer stem-like cell phenotype, but whether the Shh pathway regulates thyroid tumor cell motility and invasiveness remains unknown. Here, we report that the motility and invasiveness of two anaplastic thyroid tumor cell lines, KAT-18 and SW1736... περισσότερα »
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Hwa Young Ahn,1 Yun Jae Chung,1 Kwang-Yeol Park,2 and Bo Youn Cho1 1Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. 2Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. Address correspondence to: *Yun Jae Chung, MD, PhD* *Department of Internal Medicine* *Chung-Ang University Hospital* *224-1 Heukseok-d... περισσότερα »
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity: Thyroid , Vol. 0, No. 0. Author information Dong Gyu Na,1 Jung Hwan Baek,2 Jin Yong Sung,3 Ji-Hoon Kim,4 Jae Kyun Kim,5 Young Jun Choi,2 andHyobin Seo6 1Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea. 2Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 3Departments of Radiology, Thyroid Center, Daerim St. Mary's Hospital, Seoul,... περισσότερα »
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis: Thyroid , Vol. 0, No. 0. Author information Luciana Audi de Castroneves,1 Marcelo Vailati Negrão,2 Ricardo Miguel Costa de Freitas,3 Carla Papadia,1 José Viana Lima Jr.,4 Julia T. Fukushima,5 Eduardo Furquim Simão,6 Marco Aurélio Vamondes Kulcsar,7 Marcos Roberto Tavares,8 Alexander Augusto de Lima Jorge,9 Gilberto de Castro Jr.,2 Paulo Marcelo Hoff,2 and Ana Oliveira Hoff1 1Endocrinology Department; Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Univ... περισσότερα »
I-124 PET/CT is a valuable clinical imaging tool/agent, in both determining the extent of disease in the setting of metastatic differentiated thyroid cancer and the functional volumetric and kinetic evaluation of target lesions.
I-124 PET/CT IN PATIENTS WITH DIFFERENTIATED THYROID CANCER: CLINICAL AND QUANTITATIVE IMAGE ANALYSIS Thyroid. 2016 Feb 9; Authors: Gulec SA, Kuker RA, Goryawala M, Fernandez C, Perez R, Khan-Ghany A, Apaza A, Harja E, Harrell M Abstract BACKGROUND: Although radioactive iodine (RAI) imaging/therapy is one of the earliest applications of theranostics, there still remain a number of unresolved clinical questions as to the optimization of diagnostic techniques/protocols as well as improvements in patient-specific treatment planning strategies. The objectives of this study are to dete... περισσότερα »
Ultrasound of the Thyroid
[Ultrasound of the Thyroid] Laryngorhinootologie. 2016 Feb;95(2):87-104 Authors: Dietrich CF, Bojunga J Abstract Thyroid nodules and thyroid abnormalities are common findings in the general population. Ultrasonography is the most important imaging tool for diagnosing thyroid disease. In the majority of cases a correct diagnosis can already be made in synopsis of the sonographic together with clinical findings and basal thyroid hormone parameters and an appropriate therapy can be initiated thereafter. A differentiation of hormonally active vs. inactive nodes, and in particular beni... περισσότερα »
Comparison of Dosimetry After rhTSH or Withdrawal of Thyroid Hormone in Metastatic or Locally Advanced Thyroid Cancer
Comparison of Dosimetry After rhTSH or Withdrawal of Thyroid Hormone in Metastatic or Locally Advanced Thyroid Cancer: *Conditions*: Thyroid Cancer; Metastases *Intervention*: Drug: TSH stimulation *Sponsor*: Gustave Roussy, Cancer Campus, Grand Paris Metastases of thyroid cancer with iodine uptake are treated with repeated activity of I-131 administered after thyroid hormone withdrawal. The goal of thyroid hormone withdrawal is to treat patients with elevated thyrotropin stimulated hormone (TSH), a hormone secreted by the pituitary, a gland just located under the brain. ... περισσότερα »
BRAF analysis before surgery for papillary thyroid carcinoma
BRAF analysis before surgery for papillary thyroid carcinoma: correlation with clinicopathological features and prognosis in a single-institution prospective experience: Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print Francesca Galuppini1, a / Gianmaria Pennelli1, a / Federica Vianello2 / Simona Censi3 / Laura Zambonin3 / Sara Watutantrige-Fernando3 / Jacopo Manso 3 / Davide Nacamulli3 / Ornella Lora2 / Maria Rosa Pelizzo4 / Massimo Rugge1 / Susi Barollo3 / Caterina Mian3 1Department of Medicine (DIMED), Surgical Pathology and Cytopathology U... περισσότερα »
Production of biobutanol from cellulose hydrolysate by the Escherichia coli co-culture system
The commercialization of the *n*-butanol bioprocess is largely dependent on the price of feedstocks. Renewable cellulose appears to be an appealing feedstock. The microbial production of *n*-butanol still remains challenging because of the limited availability of intracellular NADH. To address this issue, an *Escherichia coli* strain carrying the clostridial CoA-dependent pathway was supplied with heterologous formate dehydrogenase. With the cellulose hydrolysate of rice straw, this single strain produced cellulosic biobutanol with a production yield at 35% of the theoretical and ... περισσότερα »
First description of 'Chalky back phenomenon in banana prawns (Fenneropenaeus merguiensis) and its possible association with Vibrio and Photobacterium species
Here we report a newly identified 'Chalky back' phenomenon in banana prawns (*Fenneropenaeus merguiensis*) farmed in North Queensland, Australia. This was characterized by localized white discoloured segmentation of the cervical groove, moreover, after cooking the prawns exploded, making them unfit for commercial sale. Histological examination revealed breakdown of gut and abdominal muscle tissue in some moribund specimens. We selectively isolated *Vibrio* spp., which are known prawn pathogens, from healthy and Chalky back specimens. Isolated bacteria were identified, typed and tes... περισσότερα »
Zika virus and microcephaly
Three reports have been published that together make a compelling case that Zika virus is causing microcephaly in Brazil. from Infection via ola Kala on Inoreader http://ift.tt/1QWWqR7 via IFTTT
Contamination medley
It was time for a fridge clean-out! On a BHI plate with X-gal, this colorful assortment of fungi and bacteria had probably been growing for months... from Infection via ola Kala on Inoreader http://ift.tt/1PmF5Ao via IFTTT
Value of Additional Von Kossa Staining in ThyroidNodules with Echogenic Spots on Ultrasound
Value of Additional Von Kossa Staining in ThyroidNodules with Echogenic Spots on Ultrasound via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 10 February 2016 *Source:*Pathology - Research and Practice Author(s): In Hye Chae, Hyeong Ju Kwon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Hye Sun Lee, Jin Young Kwak PurposeTo evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US).Materials and Methods342 thyroid nodules were analyzed for cytology and von Kossa st... περισσότερα »
Fluorescence in situ Hybridization (FISH)-Based Karyotyping Reveals Rapid Evolution of Centromeric and Subtelomeric Repeats in Common Bean (Phaseolus vulgaris) and Relatives.
Fluorescence *in situ* hybridization (FISH)-based karyotyping is a powerful cytogenetics tool to study chromosome organization, behavior, and chromosome evolution. Here, we developed a FISH-based karyotyping system using a probe mixture comprised of centromeric and subtelomeric satellite repeats, 5S rDNA, and chromosome-specific BAC clones in common bean, which enables one to unambiguously distinguish all eleven chromosome pairs. Furthermore, we applied the karyotyping system to several wild relatives and landraces of common bean from two distinct gene pools, as well as other rela... περισσότερα »
The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans
In response to stressful conditions, eukaryotic cells launch an arsenal of regulatory programs to protect the proteome. One major protective response involves the arrest of protein translation and the formation of stress granules, cytoplasmic ribonucleoprotein complexes containing the conserved RNA-binding proteins TIA-1 and TIAR. The stress granule response is thought to preserve mRNA for translation when conditions improve. For cells of the germline, the immortal cell lineage required for sexual reproduction, protection from stress must be critically important for perpetuation of... περισσότερα »
High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation
The ability of plasmids to propagate in *Saccharomyces cerevisiae* has been instrumental in defining eukaryotic chromosomal control elements. Stable propagation demands both plasmid replication, which requires a chromosomal replication origin (i.e. an ARS), and plasmid distribution to dividing cells, which requires either a chromosomal centromere for segregation or a plasmid-partitioning element. While our knowledge of yeast ARSs and centromeres is relatively advanced, we know less about chromosomal regions that can function as plasmid partitioning elements. The Rap1 protein-bindi... περισσότερα »
A Genetics Map for the Only Self-Fertilizing Vertebrate
The mangrove killifish, *Kryptolebias marmoratus* and its close relative *Kryptolebias hermaphroditus*, are the only vertebrate species known to reproduce by self-fertilization due to functional ovotestis development. To improve our understanding of their genomes, we constructed a genetic map. First, a single F1 fish was made by artificial fertilization between *K. marmoratus* and *K. hermaphroditus* strains. F*2* progeny were then obtained by self-fertilization of the F1 fish. We used RAD-seq to query genomic DNAs from the two parental strains, the F1 individual and 49 F2 progeny.... περισσότερα »
A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis
Congenital heart disease (CHD) is the most common developmental abnormality and is the leading non-infectious cause of mortality in neonates. Increasing evidence demonstrates that genetic defects play an important role in the pathogenesis of CHD. However, CHD is of substantial heterogeneity and the genetic determinants for CHD in an overwhelming majority of cases remain unknown. In the current study, the coding exons and flanking introns of the *HAND2* gene, which encodes a basic helix-loop-helix transcription factor essential for normal cardiovascular development, were sequenced ... περισσότερα »
Efficacy and Safety of Radiofrequency and Ethanol Ablation for Treating Locally Recurrent Thyroid Cancer: A Systematic Review and Meta-Analysis
Efficacy and Safety of Radiofrequency and Ethanol Ablation for Treating Locally Recurrent Thyroid Cancer: A Systematic Review and Meta-Analysis: Thyroid , Vol. 0, No. 0. Author information Chong Hyun Suh,1,2 Jung Hwan Baek,1 Young Jun Choi,1 and Jeong Hyun Lee1 1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 2Department of Radiology, Namwon Medical Center, Namwon, Korea. Address correspondence to: *Jung Hwan Baek, MD, PhD* *Department of Radiology and Research Institute of Radiology* *University... περισσότερα »
Treating differentiated thyroid cancer
Treating differentiated thyroid cancer: Pan X, Duan D, Zhu Y, Pang H, Guan L, Lv Z Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Objective: The aim of this study is to investigate the use of 99mTc-methoxyisobutylisonitrile (MIBI) imaging for evaluating the treatment response of differentiated thyroid cancer (DTC) after the first administration of a high dose of 131I. Methods: Patients with DTC who received 131I therapy underwent 99mTc-MIBI imaging after successive increases in the therape... περισσότερα »
Hypothyroidism and hyperthyroidism and breast cancer risk: a nationwide cohort study
Hypothyroidism and hyperthyroidism and breast cancer risk: a nationwide cohort study: Objective The association between thyroid disease and breast cancer risk remains unclear. We, therefore examined the association between hypothyroidism, hyperthyroidism and breast cancer risk. Design This was a population-based cohort study. Methods Using nationwide registries, we identified all women in Denmark with a first-time hospital diagnosis of hypothyroidism or hyperthyroidism, 1978–2013. We estimated the excess risk of breast cancer among patients with hypothyroidism or hyperthyroidism ... περισσότερα »
An Appraisal of Proliferation and Apoptotic Markers in Papillary Thyroid Carcinoma: An Automated Analysis
An Appraisal of Proliferation and Apoptotic Markers in Papillary Thyroid Carcinoma: An Automated Analysis: by Monika Lamba Saini, Caroline Bouzin, Birgit Weynand, Etienne Marbaix Introduction Proliferation and apoptosis are opposing processes by which the cell numbers are kept in a delicate balance, essential for tissue homeostasis, whereas uncontrolled growth of cells is a hallmark of cancer. Papillary thyroid cancer (PTC) is the commonest type of thyroid cancer, with some PTC following an indolent course, whereas the other ones are more aggressive. Aim To evaluate respective ... περισσότερα »
Thyroid diseases
Thyroid disease *Your thyroid is a small gland at the base of your neck that makes thyroid hormone. Thyroid hormone controls many activities in your body, including how fast you burn calories and how fast your heart beats. Diseases of the thyroid cause it to make either too much or too little of the hormone. Depending on how much or how little hormone your thyroid makes, you may often feel restless or tired, or you may lose or gain weight. Women are more likely than men to have thyroid diseases, especially right after pregnancy and after menopause.* *What is the thyroid?* *Your thyr... περισσότερα »
Ethics, research and HIV: lessons learned: a workshop report
Assessing risk for transmission of a blood-borne pathogen requires the use of the hazard and risk model. Infection control is a system that uses a number of individual processes to eliminate or reduce the probability of a hazard occurring. Strategies employed to reduce risk should be rehearsed, used routinely, audited, reviewed, and the results shared. Continuing dental education has improved dental healthcare worker willingness to treat people living with HIV/AIDS (PLWHA) and has decreased negative attitudes and staff fears. Providing care for PLWHA during undergraduate dental s... περισσότερα »
The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Molecular cell from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o5fEuI via IFTTT
A model for chronic, intrahypothalamic thyroid hormone administration in the rat
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In addition to the direct effects of thyroid hormone (TH) in peripheral organs, recent work showed metabolic effects of TH in liver and brown adipose tissue via neural pathways originating in the hypothalamic paraventricular and ventromedial nucleus (PVN and VMH). So far, these experiments focused on short-term TH administration. The aim of the present study […]
Physiological Dysregulation, Frailty, and Risk of Mortality Among Older Adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study examines whether frailty is associated with mortality independently of physiological dysregulation (PD) and, if so, which is the more accurate predictor of survival. Data come from the Social Environment and Biomarkers of Aging Study. We use Cox proportional hazard models to test the associations between PD, frailty, and 4- to 5-year survival. We […]
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent: Thyroid , Vol. 0, No. 0. Author information Trevor E. Angell,1 Melissa G. Lechner,2 Alison M. Smith,3 Sue E. Martin,3 Susan G. Groshen,4 Dennis R. Maceri,5 Peter A. Singer,6 and Alan L. Epstein3 1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts. 2Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 3Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, Ca... περισσότερα »
Connectivity and stochastic osteocyte behavior in the distribution of perilabyrinthine bone degeneration
The role of connectivity and stochastic osteocyte behavior in the distribution of perilabyrinthine bone degeneration. A Monte Carlo based simulation study via Hearing Research Publication date: Available online 10 February 2016 *Source:*Hearing Research Author(s): Sune Land Bloch, Mads Sølvsten Sørensen Previous studies of undecalcified temporal bones labeled with fluorescent tissue time markers and basic fuchsine have documented the unique spatial and temporal patterns underlying inner ear bone development, morphology and degeneration, and has led to the identification of inner ear OP... περισσότερα »
Vestibular Labyrinthectomy : Sensitivity of the Cochlear Nerve to Acoustic and Electrical Stimulation
Months After a Vestibular Labyrinthectomy in Guinea Pigs via Hearing Research Publication date: Available online 10 February 2016 *Source:*Hearing Research Author(s): D.J. Brown, P. Mukherjee, C. Pastras, W.P. Gibson, I.S. Curthoys Single-sided deafness patients are now being considered candidates to receive a cochlear implant. With this, many people who have undergone a unilateral vestibular labyrinthectomy for the treatment of chronic vertigo are now being considered for cochlear implantation. There is still some concern regarding the potential efficacy of cochlear implants in these ... περισσότερα »
PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development
Abstract Unfolded protein responses (UPR), consisting of three major transducers PERK, IRE1 and ATF6, occur in the midst of a variety of intracellular and extracellular challenges that perturb protein folding in the endoplasmic reticulum (ER). ER stress occurs and is thought to be a contributing factor to a number of human diseases, including cancer, neurodegenerative disorders and various metabolic syndromes. In the context of neoplastic growth, oncogenic stress resulting from dysregulation of oncogenes such as c-Myc, BrafV600E and HRASG12V trigger the UPR as an adaptive strategy ... περισσότερα »
Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing
Abstract Pre-mRNA splicing is a cotranscriptional process affected by the chromatin architecture along the body of coding genes. Recruited to the pre-mRNA by splicing factors, histone deacetylases (HDACs) and K-acetyltransferases (KATs) catalyze dynamic histone acetylation along the gene. In colon carcinoma HCT 116 cells, HDAC inhibition specifically increased KAT2B occupancy as well as H3 and H4 acetylation of the H3K4 trimethylated (H3K4me3) nucleosome positioned over alternative exon 2 of the *MCL1* gene, an event paralleled with the exclusion of exon 2. These results were repr... περισσότερα »
High cystatin C levels predict undesirable outcome for diabetic foot ulcerations
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract We investigated the relationship between serum cystatin C levels and the prognosis of diabetic foot ulcerations (DFU). A population-based cohort study involving 1018 patients with type 2 diabetes was conducted. These patients recruited and divided into two groups: non-diabetic-foot ulcer group (NDF,n=865,85.5%) and diabetic foot ulcer group (DFU, n=147,14.5%).After a 1-year-follow-up,DFUs were grouped into […]
A PROM primer
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ask a typical American high school girl, “What is a prom”? She will tell you that it is the final social event of high school life which is what some in the UK call a “leaver’s ball”. Ask the average American hand therapist to define the acronym PROM and she will tell you that it […]
Annual Index 2015-2016.
Authors: PMID: 26853069 [PubMed – in process] (Source: American Annals of the Deaf) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1LiwOJV via IFTTT
Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Josimar O. Eloy, Raquel Petrilli, José Fernando Topan, Heriton Marcelo Ribeiro Antonio, Juliana Palma Abriata Barcellos, Deise L. Chesca, Luciano Neder Serafini, Daniel G. Tiezzi, Robert J. Lee, Juliana Maldonado Marchetti Paclitaxel and rapamycin have been reported to act synergistically to treat… Continue reading Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy
Increasing Self-Regulation and Classroom Participation of a Child Who Is Deafblind.
Authors: Nelson C, Hyte HA, Greenfield R Abstract Self-regulation has been identified as essential to school success. However, for a variety of reasons, its development may be compromised in children and youth who are deafblind. A single-case multiple-baseline study of a child who was deafblind examined the effects of three groups of evidence-based interventions on… Continue reading Increasing Self-Regulation and Classroom Participation of a Child Who Is Deafblind.
Sorafenib and gadolinium co-loaded liposomes for drug delivery and MRI-guided HCC treatment
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Yanan Xiao, Yongjun Liu, Shaomei Yang, Bo Zhang, Tianqi Wang, Dandan Jiang, Jing Zhang, Dexin Yu, Na Zhang To improve the poor water solubility of sorafenib and to monitor its distribution and the early feedback effects on its in vivo treatment efficacy… Continue reading Sorafenib and gadolinium co-loaded liposomes for drug delivery and MRI-guided HCC treatment
Successful Students Who Are Deaf or Hard of Hearing and Culturally and/or Linguistically Diverse in Inclusive Settings.
Authors: Ayantoye CA, Luckner JL Abstract The population of students who are deaf or hard of hearing is becoming more culturally and/or linguistically diverse. However, there is a paucity of practitioner literature and research available to professionals and families to guide decision making about daily practices with these students and their families. The study identified… Continue reading Successful Students Who Are Deaf or Hard of Hearing and Culturally and/or Linguistically Diverse in Inclusive Settings.
A Discourse of «Abnormality»: Exploring Discussions of People Living in Australia With Deafness or Hearing Loss.
Discussions of People Living in Australia With Deafness or Hearing Loss. Am Ann Deaf. 2016;160(5):483-95 Authors: Ferndale D, Munro L, Watson B Abstract Adopting a social constructionist framework, the authors conducted a synthetic discourse analysis to explore how people living in Australia with deafness construct their experience of deafness. An online forum facilitated access and… Continue reading A Discourse of «Abnormality»: Exploring Discussions of People Living in Australia With Deafness or Hearing Loss.
Assembly of designed protein scaffolds into monolayers for nanoparticle patterning
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Sara H. Mejias, Pierre Couleaud, Santiago Casado, Daniel Granados, Miguel Angel Garcia, Jose M. Abad, Aitziber L. Cortajarena The controlled assembly of building blocks to achieve new nanostructured materials with defined properties at different length scales through rational design is the basis… Continue reading Assembly of designed protein scaffolds into monolayers for nanoparticle patterning
In Memoriam: Jerry B. Crittenden.
Authors: Paul PV PMID: 26853063 [PubMed – in process] (Source: American Annals of the Deaf) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1LiwOd9 via IFTTT
In vitro studies on human periodontal ligament stem cell sheets enhanced by enamel matrix derivative
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Zhongshan Wang, Zhihong Feng, Guofeng Wu, Shizhu Bai, Yan Dong, Yimin Zhao Numerous preclinical and clinical studies have focused on the periodontal regenerative functions of enamel matrix derivative (EMD), a heat-treated preparation derived from enamel matrix proteins (EMPs) of developing porcine teeth.… Continue reading In vitro studies on human periodontal ligament stem cell sheets enhanced by enamel matrix derivative
This Issue: Something for Almost Everybody.
This Issue: Something for <i>Almost</i> Everybody. Am Ann Deaf. 2016;160(5):433-6 Authors: Paul PV PMID: 26853062 [PubMed – in process] (Source: American Annals of the Deaf) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1o5aHlI via… Continue reading This Issue: Something for Almost Everybody.
Aqueous two-phase system cold-set gelation using natural and recombinant probiotic lactic acid bacteria as a gelling agent
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Lucie Léonard, Florence Husson, Philippe Langella, Jean-Marc Châtel, Rémi Saurel The present study aimed to entrap probiotic lactic acid bacteria (LAB) in a sodium alginate and sodium caseinate aqueous two-phase gel system. The natural acidifying properties of two therapeutic probiotic LAB were […]
Real-time measurements to characterize dynamics of emulsion interface during simulated intestinal digestion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Yuanjie Pan, N. Nitin Efficient delivery of bioactives remains a critical challenge due to their limited bioavailability and solubility. While many encapsulation systems are designed to modulate the digestion and release of bioactives within the human gastrointestinal tract, there is limited understanding […]
Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus–sodium dodecyl sulfate complex
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Dengning Xia, Hongzhen Yu, Jinsong Tao, Jianrong Zeng, Quanlei Zhu, Chunliu Zhu, Yong Gan Our previous study demonstrated that the retention of drug in the hydrophobic core of Soluplus micelle greatly impeded drug absorption from gastrointestinal tract. Using supersaturated polymeric micelles can […]
An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Xinfeng Cheng, Yong Jin, Tongbing Sun, Rui Qi, Hanping Li, Wuhou Fan A novel pH and oxidation dual-responsive and injectable supramolecular hydrogel was developed, which was formed from multi-block copolymer poly(ether urethane) (PEU) and α-cyclodextrin (α-CD) inclusion complexes (ICs). The PEU copolymer […]
The preparation of novel adsorbent materials with efficient adsorption performance for both chromium and methylene blue
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Leilei Li, Feng Liu, Huimin Duan, Xiaojiao Wang, Jianbo Li, Yanhui Wang, Chuannan Luo The hydroxy-functionalized ionic liquids (ILs) modified with magnetic chitosan/grapheneoxide (MG-ILs-OH) were synthesized. The surface morphology of MG-ILs-OH was characterized by transmission electron microscopy, X-ray diffraction, thermo gravimetric analysis […]
Rhodanese incorporated in Langmuir and Langmuir–Blodgett films of dimyristoylphosphatidic acid: Physical chemical properties and improvement of the enzyme activity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Felipe Tejada de Araújo, Luciano Caseli Preserving the catalytic activity of enzymes immobilized in bioelectronics devices is essential for optimal performance in biosensors. Therefore, ultrathin films in which the architecture can be controlled at the molecular level are of interest. In this […]
Yoga for Adult Women with Chronic PTSD: A Long-term Follow-up Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1POJgXj via IFTTT
Editorial Board/Aims & Scope
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Oral Oncology, Volume 54 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1otwEdO via IFTTT
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 10 February 2016 Source:Oral Oncology Author(s): S.A.C. Kraaijenga, I.M. Oskam, R.J.J.H. van Son, O. Hamming-Vrieze, F.J.M. Hilgers, M.W.M. van den Brekel, L. van der Molen ObjectivesAssessment of long-term objective and subjective voice, speech, articulation, and quality of life in patients with head and neck cancer (HNC) treated with concurrent chemoradiotherapy (CRT) […]
Control of the Position of Oxygen Delivery in Soybean Lipoxygenase-1 by Amino Acid Side Chains within a Gas Migration Channel. Protein Structure and Folding
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Understanding gas migration pathways is critical to unraveling structure-function relationships in enzymes that process gaseous substrates such as O2, H2 and N2. This work investigates the role of a defined pathway for O2 in regulating the peroxidation of linoleic acid by soybean lipoxygenase 1 (SLO-1). Computational and mutagenesis studies provide strong support for a dominant […]
Spastic Paralysis of the Elbow and Forearm
Seminars in Plastic Surgery 2016; 30: 039-044 DOI: 10.1055/s-0035-1571255 As the physiologic recovery period concludes, the patient is evaluated for surgical procedures that may rebalance muscle function and correct deformity. Upper extremity function is the product of complex and highly sophisticated mechanisms working in unison, and a careful, systematic preoperative evaluation is critical. A good function of the hand cannot be achieved without adequate position of the shoulder, elbow, forearm, and wrist. The goals of surgery must be practical and clearly understood by the patie... περισσότερα »
Botulinum Toxin in the Treatment of Pediatric Upper Limb Spasticity
Seminars in Plastic Surgery 2016; 30: 024-028 DOI: 10.1055/s-0036-1571302 Botulinum neurotoxin (BoNT) is one of the mainstays in the treatment of pediatric spasticity and dystonia. When considering initiation of BoNT treatment for spasticity, treatment goals and responses to prior conservative measures such as passive range of motion exercises, splinting, and other medication trials should be reviewed. As a general rule, children should be engaged in therapy services around the time of the injections and have a robust home program in place. When managing spasticity in children wit... περισσότερα »
Pediatric Upper Limb Spasticity
Seminars in Plastic Surgery 2016; 30: 003-004 DOI: 10.1055/s-0036-1571300 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QsRvEK via IFTTT
Review of Therapeutic Interventions for the Upper Limb Classified by Manual Ability in Children with Cerebral Palsy
Seminars in Plastic Surgery 2016; 30: 014-023 DOI: 10.1055/s-0035-1571256 The aim of this literature review was to assemble an inventory of intervention strategies utilized for children diagnosed with cerebral palsy (CP) based on the Manual Ability Classification System (MACS). The purpose of the inventory is to guide physicians and therapists in intervention selection aimed at improving upper limb function in children with CP. The following databases were searched: CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane Database of Systematic Reviews, ERIC (Ed... περισσότερα »
Grading and Quantification of Upper Extremity Function in Children with Spasticity
Seminars in Plastic Surgery 2016; 30: 005-013 DOI: 10.1055/s-0035-1571257 The World Health Organization's International Classification of Functioning, Disability and Health (ICF) provides an ideal framework within which to conceptualize grading and quantification of upper extremity function for children with spasticity. In this article the authors provide an overview of assessments and classification tools used to (1) understand upper extremity function associated with spasticity and the factors that contribute to dysfunction, (2) guide the selection of appropriate interventions, ... περισσότερα »
Surgical Treatment of Pediatric Upper Limb Spasticity: The Wrist and Hand
Seminars in Plastic Surgery 2016; 30: 029-038 DOI: 10.1055/s-0035-1571254 The wrist and hand are essential in the placement of the upper extremity in a functional position for grasp, pinch, and release activities. This depends on the delicate balance between the extrinsic and intrinsic muscles of the wrist and hand. Spasticity alters this equilibrium, limiting the interaction of the upper limb with the environment. Classically, pediatric patients with upper limb spasticity present with a flexed wrist, thumb-in-palm, and flexed finger posture. These contractures are typically secon... περισσότερα »
Surgical Treatment of Pediatric Upper Limb Spasticity: The Shoulder
Seminars in Plastic Surgery 2016; 30: 045-050 DOI: 10.1055/s-0035-1571253 The shoulder joint is essential for placing the hand in a functional position for reach and overhead activities. This depends on the delicate balance between abductor/adductor and internal/external rotator muscles. Spasticity alters this equilibrium, limiting the interaction of the upper limb with the environment. Classically, pediatric patients with upper limb spasticity present with an adduction and internal rotation contracture of the shoulder. These contractures are typically secondary to spasticity of t... περισσότερα »
Mitchel Seruya, MD
Seminars in Plastic Surgery 2016; 30: 001-002 DOI: 10.1055/s-0036-1571301 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/23YcPfh via IFTTT
Potential role of systemic thrombolysis in acute submassive intermediate risk pulmonary embolism: review and future perspectives
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Submassive (intermediate risk) pulmonary embolism (PE) continues to be a significantly morbid disease process that remains unrecognized, inadequately risk stratified and suboptimally treated. Appropriate early clinical and imaging-based risk stratification represents the cornerstone for adequate therapeutic decision making, particularly for the selection of candidates who may benefit the most from systemic thrombolysis. The relevance of […]
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