Basaloid Carcinoma of the Esophagus with Lugol-Voiding Lesions
[Basaloid Carcinoma of the Esophagus with Lugol-Voiding Lesions-A Case Report].: Gan To Kagaku Ryoho. Authors: Shimakawa T, Asaka S, Shimazaki A, Yamaguchi K, Usui T, Yokomizo H, Shiozawa S, Yoshimatsu K, Katsube T, Naritaka Y, Fujibayashi M Abstract Patients with Lugol-voiding lesions of the esophagus are frequently affected with multiple cancers. Basaloid carcinoma of the esophagus is a very rare disease characterized by growth in the submucosal layer that exhibits a submucosal tumor-like shape. There have been some reports that this type of carcinoma is biologically high-grade.... περισσότερα »
Overexpression of cyclin A in oral dysplasia
Overexpression of cyclin A in oral dysplasia: An international comparison and literature review: *R Tandon, LL Cunningham, DK White, AS Herford, M Cicciu* Indian Journal of Cancer Oral squamous cell carcinoma (OSCC) is one of the most debilitating cancers in the world and while its causes have been heavily researched, the outcome remains grim. Most of these cancers are identified in the late stage and as a result treatment options are limited. Therefore, researchers have focused their efforts on recognizing and identifying dysplastic tissue that has an increased chance of progressi...περισσότερα »
Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis.
Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis Sci Rep. 2016;6:20208 Authors: Wu T, Hong Y, Jia L, Wu J, Xia J, Wang J, Hu Q, Cheng B Abstract Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes in TME for future intervention in dysplasia to interrupt oral carcinogenesis wa... περισσότερα »
18F-FDG PET–CT performed before and during radiation therapy of head and neck squamous cell carcinoma: Are they independent or complementary to each other?
Abstract Introduction The aims of this study are to evaluate the prognostic value of metabolic parameters derived from 18F-FDG PET-CT performed before definitive radiation therapy (RT) (prePET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC) and to assess the additive prognostic values of FDG PET-CT performed during RT (iPET). Methods One… Continue reading 18F-FDG PET–CT performed before and during radiation therapy of head and neck squamous cell carcinoma: Are they independent or complementary to each other?
Development of a more streamlined approach to pregnancy screening before nuclear medicine procedures
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mw4CNa via IFTTT
Prevalence and associated factors of HIV infection among men who have sex with men in Hefei, China, 2013-2014: a cross-sectional study
The objective of this study was to investigate the prevalence and influencing factors of HIV infection among men who have sex with men (MSM) in Hefei, China. A total of 578 MSM were recruited, with a mean age of 28.13 ± 6.91; 70.7% were under 30. The awareness rate was 95.4% (560/587) in the cross-sectional… Continue reading Prevalence and associated factors of HIV infection among men who have sex with men in Hefei, China, 2013-2014: a cross-sectional study
Mycoplasma genitalium: a possible case of macrolide resistance from Lebanon
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Lkkc5h via IFTTT
Sex workers, condoms, and mobility among men in Uzbekistan: implications for HIV transmission
Uzbekistan has one of the fastest growing HIV epidemics in the world. In this study, men who reported mobility were compared to non-mobile men in regard to paying for sex and condom use during paid sex. The sample included 2333 men between the ages of 15 and 59 in Uzbekistan. Generalised linear models were used… Continue reading Sex workers, condoms, and mobility among men in Uzbekistan: implications for HIV transmission
Ineffective central nervous system HIV suppression of once-a-day maraviroc and ritonavir-boosted darunavir dual therapy: four case reports
Novel two-drug combinations including a protease inhibitor are an attractive nucleoside reverse transcriptase inhibitor sparing option for some patients, particularly as a switch strategy. We have used the two-drug combination of maraviroc and darunavir/ritonavir once a day as a switch strategy in patients with stable low or undetectable plasma HIV viral loads, but identified four… Continue reading Ineffective central nervous system HIV suppression of once-a-day maraviroc and ritonavir-boosted darunavir dual therapy: four case reports
Sexual health risks, service use, and views of rapid point-of-care testing among men who have sex with men attending saunas: a cross-sectional survey
Guidelines highlight the need to increase HIV testing among men who have sex with men (MSM) and novel point-of-care testing provides new possibilities for delivery of care. However, it is unclear how point-of-care testing should be used to best effect. This study aimed to increase understanding of sexual risk-taking behaviour, service use, and attitudes to… Continue reading Sexual health risks, service use, and views of rapid point-of-care testing among men who have sex with men attending saunas: a cross-sectional survey
Chorioamnionitis in pregnancy: a comparative study of HIV-positive and HIV-negative parturients
Chorioamnionitis is an important risk factor for vertical transmission of HIV/AIDS. We compared the prevalence and correlates of histologic chorioamnionitis (HCA) in HIV-positive and HIV-negative pregnant women. HIV-positive and -negative parturients were interviewed, examined and had their placentas examined histologically for chorioamnionitis. Data regarding HIV were also retrieved from their hospital records. A total of… Continue reading Chorioamnionitis in pregnancy: a comparative study of HIV-positive and HIV-negative parturients
HIV testing behaviour and use of risk reduction strategies by HIV risk category among MSM in Vancouver
We carried out an analysis of a serobehavioural study of men who have sex with men >19 years of age in Vancouver, Canada to examine HIV testing behaviour and use of risk reduction strategies by HIV risk category, as defined by routinely gathered clinical data. We restricted our analysis to those who self-identified as HIV-negative,… Continue reading HIV testing behaviour and use of risk reduction strategies by HIV risk category among MSM in Vancouver
Novel Calcium Nanoparticles Inhibit Tumor Growth
[image: drugs]Researchers at Washington University in St. Louis have developed a new calcium nanoparticle to stop the growth and metastisis of tumors. In order for cancer cells to grow and spread, they often lower their pH to escape the surrounding extracellular matrix. Using this information, a research team led by Avik Som, an MD/PhD student, and Samuel Achilefu, PhD, utilized calcium carbonate to raise pH. When calcium carbonate is mixed into water, it can cause the pH to rise up to ~9 which is harmful to humans; however, when injected into the body, it only raises the pH to ~7... περισσότερα »
Adverse Effects of Ball-Chain Radio-Collars on Female Mantled Howlers ( Alouatta palliata ) in Panama
Abstract The placement of radio- and GPS-collars on primates has advanced the fields of primate behavior and ecology and yielded considerable conservation gains. However, to ensure that the placement of tracking collars remains a humane practice, the reporting of both positive and negative outcomes is required. Here, we evaluate the impacts of radio-collars on the reproduction, behavior, and health of female mantled howlers (*Alouatta palliata*) on Barro Colorado Island, Panama. In June 2005, as part of a behavioral study, we fitted 16 female howlers with ball-chain radio-collars ... περισσότερα »
Toward a Boron-Doped Ultrananocrystalline Diamond Electrode-Based Dielectrophoretic Preconcentrator
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03227 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PQpx9M via IFTTT
Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04391 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1O5TzRm via IFTTT
ELAKCA: Enzyme-Linked Aptamer Kissing Complex Assay as a Small Molecule Sensing Platform
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04575 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SkBMNT via IFTTT
Functional Nucleic Acid Probe for Parallel Monitoring K+ and Protoporphyrin IX in Living Organisms
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04936 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1Tfno9P via IFTTT
Application of Market Basket Analysis for the Visualization of Transaction Data Based on Human Lifestyle and Spectroscopic Measurements
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04182 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PpsIDV via IFTTT
Characterization of Actinides Complexed to Nuclear Fuel Constituents Using ESI-MS
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03352 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1KIL3g6 via IFTTT
Determination of Atto- to Femtogram Levels of Americium and Curium Isotopes in Large-Volume Urine Samples by Compact Accelerator Mass Spectrometry
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04546 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1o7GF0C via IFTTT
High-Sensitivity Measurement of Density by Magnetic Levitation
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03918 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1KejbRc via IFTTT
Enzymatic Oxydate-Triggered Self-Illuminated Photoelectrochemical Sensing Platform for Portable Immunoassay Using Digital Multimeter
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00262 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1o3DfeB via IFTTT
Optimized Ultrasound Conditions for Enhanced Sensitivity of Molecular Beacons in the Detection of MDR1 mRNA in Living Cells
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04503 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1Kej9sv via IFTTT
Automated Agitation-Assisted Demulsification Dispersive Liquid–Liquid Microextraction
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03919 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1KejbAz via IFTTT
Comparative study of organic matter chemical characterization using negative and positive mode electrospray ionization ultrahigh-resolution mass spectrometry
Abstract The chemical characterization of dissolved organic matter (DOM) is critical for understanding carbon sequestration processes in soils. This work evaluated the use of electrospray ionization in both negative ion mode (ESI−) and positive ion mode (ESI+) for the characterization of DOM extracted from nine terrestrial sources using Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS). The compositing of the peaks from ESI− to ESI+ modes increased the total assigned formulas from 23 to 63 % as compared to the traditional use of ESI− alone for DOM characterization. In ... περισσότερα »
Metabolites profiling of 10 bufadienolides in human liver microsomes and their cytotoxicity variation in HepG2 cell
Abstract Bufadienolides, a class of polyhydroxy steroids, exhibit significant antitumor activity. In this study, a total of 39 metabolites from 10 bufadienolides were detected and identified by ultrahigh-performance liquid chromatography (UHPLC) coupled with an LTQ Orbitrap mass spectrometer. The results showed that hydroxylation and dehydrogenation were the major metabolic pathways of bufadienolides in human liver microsomes (HLMs). CYP3A4 was found to be the major metabolic enzyme and CYP2D6 only mediated the dehydrogenation reaction. A systematic validated cytotoxicity evaluati...περισσότερα »
Evaluation of a reconfigurable portable instrument for copper determination based on luminescent carbon dots
Abstract A portable reconfigurable platform for copper (Cu(II)) determination based on luminescent carbon dot (Cdots) quenching is described. The electronic setup consists of a light-emitting diode (LED) as the carbon dot optical exciter and a photodiode as a light-to-current converter integrated in the same instrument. Moreover, the overall analog conditioning is simply performed with one integrated solution, a field-programmable analog array (FPAA), which makes it possible to reconfigure the filter and gain stages in real time. This feature provides adaptability to use the platfo... περισσότερα »
Simultaneous electrochemical determination of dopamine and 5-hydroxyindoleacetic acid in urine using a screen-printed graphite electrode modified with gold nanoparticles
Abstract The authors describe a disposable screen-printed graphite electrode (SPGE) modified with gold nanoparticles (AuNPs). The electrode, designated as AuNPs-SPGE, was characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The AuNPs-SPGE combines the electrochemical features of graphite and the disposability of screen-printed electrodes. It displays excellent electrocatalytic activity towards dopamine (DA) and 5-hydroxyindoleacetic acid (5-HIAA). Two well-defined, sharp, and fully resolved voltammetric peaks (at 525 mV for DA and at 415 mV for 5-HIAA, b... περισσότερα »
Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether
Abstract Mycotoxins are secondary plant metabolites that have been found to cause severe diseases in humans and livestock. Exposure can take place on a daily basis since mycotoxins can be found not only in food, animal food, and dietary supplements but also in materials used in buildings. For this work, the *Alternaria* toxins alternariol (AOH) and alternariol methyl ether (AME) are chosen as representatives for this relevant compound class and are investigated regarding their oxidative phase I metabolism using a combination of electrochemical (EC) oxidation and high-resolution el...περισσότερα »
Protein Counting in Single Cancer Cells
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00146 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1V6KwoK via IFTTT
Gas Evolution in LiNi0.5Mn1.5O4/Graphite Cells Studied In Operando by a Combination of Differential Electrochemical Mass Spectrometry, Neutron Imaging, and Pressure Measurements
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04696 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1V6KugN via IFTTT
Predictors of obstructive sleep apnea in lung transplant recipients
• The prevalence of SDB in 77 clinically stable lung transplant recipients was 49.4%.• Pre-transplant COPD is an independent predictor of SDB.• OSA was significantly associated with neck circumference and pre-transplant COPD/IPF.• Lung transplant recipients with SDB often do not show SDB symptoms.• Subjects with SDB might benefit from continuous positive airway pressure therapy. from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/1PGArLI via IFTTT
Childhood adversity and insomnia in adolescence
Three significant findings emerge from this study.• We found that youth exposed to adversity are more likely to have insomnia during adolescence and the prevalence of insomnia differs by type of adversity.• For certain types of adversities, the risk for insomnia differed based on age at first exposure. This finding is consistent with the notion of "sensitive periods" in development.• There was a clear dose-response relationship between number of childhood adversities reported and risk for insomnia. from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/1XmH8Yg via IFTTT
Candidate Mechanisms Underlying the Association Between Sleep-Wake Disruptions and Alzheimer’s disease
During wakefulness, extracellular levels of metabolites in the brain increase. These include amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer's disease (AD). Counterbalancing their accumulation in the brain, sleep greatly facilitates the removal of these metabolites from the extracellular space by convective flow of the interstitial fluid from the para-arterial to the para-venous space. However, when the sleep-wake cycle is disrupted (characterized by increased brain levels of the wake-promoting neuropeptide orexin and increased neural activity), the central n... περισσότερα »
Differential Isotope Labeling of 38 Dietary Polyphenols and Their Quantification in Urine by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03609 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SjXL7D via IFTTT
Liquid–Liquid Extraction and Solid Phase Extraction for Urinary Organic Acids: A Comparative Study from a Resource Constraint Setting
Abstract Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean reco... περισσότερα »
An anonymous Thirteenth Century lyric
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mw0Tzj via IFTTT
Incorporating Midbrain Adaptation to Mean Sound Level Improves Models of Auditory Cortical Processing
The Journal of Neuroscience from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qbnkri via IFTTT
Idiosyncratic responding during movie-watching predicted by age differences in attentional control
Neurobiology of Aging from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qbnjnn via IFTTT
A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia
Neurobiology of Aging from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qbnjnf via IFTTT
Total MRI load of cerebral small vessel disease and cognitive ability in older people
Neurobiology of Aging from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mw0PzA via IFTTT
Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer’s disease
Neurobiology of Aging from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qbnj6T via IFTTT
Rare Causes of Primary Adrenal Insufficiency: Genetic and Clinical Characterization of a Large Nationwide Cohort
The Journal of Clinical Endocrinology and Metabolism from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mw0RaE via IFTTT
White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome
The Journal of Clinical Endocrinology and Metabolism from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mw0Pj6 via IFTTT
Overview of the Management of Cough: CHEST Guideline and Expert Panel Report
Chest from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mw0QUg via IFTTT
Patient-Reported Outcomes Assessed by the CAMPHOR Questionnaire Predict Clinical Deterioration in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Chest from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1QbngYB via IFTTT
Brain MR Imaging Findings of Cardiac-Type Fabry Disease with an IVS4+919G>A Mutation [PEDIATRICS]
BACKGROUND AND PURPOSE: A high incidence of cardiac-type Fabry disease with an α-galactosidase A mutation, IVS4 + 919 G>A, has been identified in the Taiwanese population. The neurologic manifestation has not been understood in this specific cardiac variant. This study aimed to investigate the typical imaging features of classic Fabry disease in patients with IVS4 Fabry disease. MATERIALS AND METHODS: Twenty-six patients with IVS4-type Fabry disease (20 men and 6 women; age range, 43–71 years; median age, 61 years) and 26 age- and sex-matched healthy controls (age range, 44–68 y... περισσότερα »
New Clinically Feasible 3T MRI Protocol to Discriminate Internal Brain Stem Anatomy [ADULT BRAIN]
SUMMARY: Two new 3T MR imaging contrast methods, track density imaging and echo modulation curve T2 mapping, were combined with simultaneous multisection acquisition to reveal exquisite anatomic detail at 7 canonical levels of the brain stem. Compared with conventional MR imaging contrasts, many individual brain stem tracts and nuclear groups were directly visualized for the first time at 3T. This new approach is clinically practical and feasible (total scan time = 20 minutes), allowing better brain stem anatomic localization and characterization. from #Neuroscience via alexand...περισσότερα »
Multicenter Prospective Trial of Stent Placement in Patients with Symptomatic High-Grade Intracranial Stenosis [ADULT BRAIN]
BACKGROUND AND PURPOSE: On the basis of the high 1-month stroke and/or death (14.7%) rates associated with stent placement in the Stenting versus Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis trial, modifications in patient selection and procedural aspects for intracranial stent placement have been recommended. We performed a multicenter prospective single-arm trial to determine whether such modifications would result in lower rates of periprocedural stroke and/or death. MATERIALS AND METHODS: The study enrolled patients with recent trans...περισσότερα »
Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers [PEDIATRICS]
BACKGROUND AND PURPOSE: Deletion and duplication of chromosome 16p11.2 (*BP4–BP5*) have been associated with developmental disorders such as autism spectrum disorders, and deletion subjects exhibit a large (20-ms) delay of the auditory evoked cortical response as measured by magnetoencephalography (M100 latency). The purpose of this study was to use a multimodal approach to test whether changes in white matter microstructure are associated with delayed M100 latency. MATERIALS AND METHODS: Thirty pediatric deletion carriers, 9 duplication carriers, and 39 control children were s... περισσότερα »
The "Hyperdense Paraspinal Vein" Sign: A Marker of CSF-Venous Fistula [SPINE]
SUMMARY: CSF-venous fistula is a recently reported cause of spontaneous intracranial hypotension that may occur in the absence of myelographic evidence of CSF leak. Information about this entity is currently very limited, but it is of potential importance given the large percentage of cases of spontaneous intracranial hypotension associated with negative myelography findings. We report 3 additional cases of CSF-venous fistula and describe the "hyperdense paraspinal vein" sign, which may aid in its detection. from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.t... περισσότερα »
Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure [ADULT BRAIN]
BACKGROUND AND PURPOSE: Patients with spontaneous intracranial hypotension often exhibit low CSF pressure and changes on brain MR imaging and/or evidence of CSF leak on myelography. We investigated whether individual imaging signs of spontaneous intracranial hypotension correlate with measured CSF pressure and how frequently these 2 markers of spontaneous intracranial hypotension were concordant. MATERIALS AND METHODS: We performed a retrospective, cross-sectional study of 99 subjects with spontaneous intracranial hypotension. Prevalence of brain and myelographic imaging signs ... περισσότερα »
Radiation Dose Reduction by Indication-Directed Focused z-Direction Coverage for Neck CT [PEDIATRICS]
BACKGROUND AND PURPOSE: The American College of Radiology–American Society of Neuroradiology–Society for Pediatric Radiology Practice Parameter for a neck CT suggests that coverage should be from the sella to the aortic arch. It also recommends using CT scans judiciously to achieve the clinical objective. Our purpose was to analyze the potential dose reduction by decreasing the scan length of a neck CT and to assess for any clinically relevant information that might be missed from this modified approach. MATERIALS AND METHODS: This retrospective study included 126 children who u... περισσότερα »
Outcomes of long term iron supplementation in pediatric restless leg syndrome / periodic limb movement disorder (RLS/PLMD)
• Iron therapy is an effective treatment for pediatric RLS/PLMD.• Treatment results in improvement of PLMS indices and subjective symptoms.• Long term improvement is sustained in the majority of patients from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1PGAuqI via IFTTT
High prevalence of post-stroke sleep disordered breathing in mexican americans
• Mexican American (MA) stroke patients have a high burden of SDB.• SDB risk factors and stroke severity do not explain greater prevalence of SDB in MAs.• Physicians treating MA stroke patients should have a high index of suspicion for SDB. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1TfHr8c via IFTTT
Changes in sleep duration in spanish children aged 2–14 years from 1987 to 2011
• Sleep duration was assessed in Spanish children from 1987 to 2011.• Sleep duration in children has decreased by about 20 minutes over the last two decades.• Short sleep is significantly associated with obesity, socio-economic status, and exercise.• Children in Spain sleep less than their Swiss or English counterparts. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1PGAuaq via IFTTT
Influence of sleep disturbances on age at onset and long-term incidence of major cardiovascular events: the MONICA-brianza and PAMELA cohort studies
• Sleep disturbances and long sleep duration were associated with cardiovascular disease (CVD) in Italian men.• All associations were independent of classic CVD risk factors and depression.• Use of a questionnaire assessing different levels of disturbances improved CVD prediction.• The association between severe disturbances and CVD was evident from age 48 years.• Assessment of levels of sleep disturbances could be useful in early CVD prevention. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1TfHsc4 via IFTTT
Predictors of obstructive sleep apnea in lung transplant recipients
• The prevalence of SDB in 77 clinically stable lung transplant recipients was 49.4%.• Pre-transplant COPD is an independent predictor of SDB.• OSA was significantly associated with neck circumference and pre-transplant COPD/IPF.• Lung transplant recipients with SDB often do not show SDB symptoms.• Subjects with SDB might benefit from continuous positive airway pressure therapy. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1PGArLI via IFTTT
Childhood adversity and insomnia in adolescence
Three significant findings emerge from this study.• We found that youth exposed to adversity are more likely to have insomnia during adolescence and the prevalence of insomnia differs by type of adversity.• For certain types of adversities, the risk for insomnia differed based on age at first exposure. This finding is consistent with the notion of "sensitive periods" in development.• There was a clear dose-response relationship between number of childhood adversities reported and risk for insomnia. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1XmH8Yg via IFTTT
Ineffective central nervous system HIV suppression of once-a-day maraviroc and ritonavir-boosted darunavir dual therapy: four case reports
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Novel two-drug combinations including a protease inhibitor are an attractive nucleoside reverse transcriptase inhibitor sparing option for some patients, particularly as a switch strategy. We have used the two-drug combination of maraviroc and darunavir/ritonavir once a day as a switch strategy in patients with stable low or undetectable plasma HIV viral loads, but identified four […]
Sexual health risks, service use, and views of rapid point-of-care testing among men who have sex with men attending saunas: a cross-sectional survey
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Guidelines highlight the need to increase HIV testing among men who have sex with men (MSM) and novel point-of-care testing provides new possibilities for delivery of care. However, it is unclear how point-of-care testing should be used to best effect. This study aimed to increase understanding of sexual risk-taking behaviour, service use, and attitudes to […]
Chorioamnionitis in pregnancy: a comparative study of HIV-positive and HIV-negative parturients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Chorioamnionitis is an important risk factor for vertical transmission of HIV/AIDS. We compared the prevalence and correlates of histologic chorioamnionitis (HCA) in HIV-positive and HIV-negative pregnant women. HIV-positive and -negative parturients were interviewed, examined and had their placentas examined histologically for chorioamnionitis. Data regarding HIV were also retrieved from their hospital records. A total of […]
HIV testing behaviour and use of risk reduction strategies by HIV risk category among MSM in Vancouver
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
We carried out an analysis of a serobehavioural study of men who have sex with men >19 years of age in Vancouver, Canada to examine HIV testing behaviour and use of risk reduction strategies by HIV risk category, as defined by routinely gathered clinical data. We restricted our analysis to those who self-identified as HIV-negative, […]
Correlates of anal sex roles among Malay and Chinese MSM in Kuala Lumpur, Malaysia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Identifying roles for anal sex is an important issue for populations of MSM. We describe the prevalence of identifying as being ‘top’, ‘bottom’, ‘versatile’, or ‘don’t know/not applicable’ among Malay and Chinese MSM in Kuala Lumpur, Malaysia, and behavioural outcomes according to these labels for sexual role identity. Data analysis was conducted on a survey […]
Effect of HIV diagnosis disclosure on psychosocial outcomes in Thai children with perinatal HIV infection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
A provider-assisted, counselling-based, paediatric HIV disclosure model was developed and implemented at two tertiary-care hospitals in Bangkok, Thailand. All undisclosed perinatally acquired HIV-infected children, aged 7–18 years, and their caretakers were offered the four-step disclosure service, including: screening, readiness assessments and preparation, disclosure sessions, and follow-up evaluations. To assess psychosocial outcomes of disclosure, we compared […]
Stromal myofibroblasts in oral squamous cell carcinoma and potentially malignant disorders
Stromal myofibroblasts in oral squamous cell carcinoma and potentially malignant disorders: *G Jayaraj, HJ Sherlin, P Ramani, P Premkumar, A Natesan* Indian Journal of Cancer Introduction: Concurrent with the progression of a non- diseased epithelium to the pre-cancerous epithelium to carcinoma, the stroma also undergoes modifications. Myofibroblasts are important stromal cells that play a crucial role in carcinogenesis. The current study investigated the presence of myofibroblasts in healthy oral mucosa, potentially malignant disorders (PMDs) and squamous cell carcinoma (SCC)....περισσότερα »
Galectin-1 is a useful marker for detecting neoplasticsquamous cells in oral cytology smears
Galectin-1 is a useful marker for detecting neoplasticsquamous cells in oral cytology smears via Human Pathology Publication date: Available online February 2016 *Source:*Human Pathology Author(s): Yuri Noda, Yuko Kondo, Manabu Sakai, Sunao Sato, Mitsunobu Kishino Cytological diagnoses in the oral region are very difficult due to the small amount of cells in smears, which are also exposed to many stimulating factors and often show atypical changes. Galectin-1 (Gal1) is a beta-galactoside binding protein that modulates tumor progression. Gal1 is very weakly expressed in normal cells, b...περισσότερα »
Laryngeal Squamous Intraepithelial Lesions
Laryngeal Squamous Intraepithelial Lesions: An Updated Review on Etiology, Classification, Molecular Changes, and Treatment Adv Anat Pathol. 2016 Mar;23(2):84-91 Authors: Gale N, Gnepp DR, Poljak M, Strojan P, Cardesa A, Helliwell T, Šifrer R, Volavšek M, Sandison A, Zidar N Abstract Laryngeal carcinogenesis is a multistep process, characterized by an accumulation of genetic changes associated with architectural and cytologic alterations, ranging from squamous hyperplasia to carcinoma in situ and encompassed by the terminology of squamous intraepithelial lesions (SILs). The etiolo... περισσότερα »
Cranio-facial remodeling is associated with changes in larynx position
in domestic dogs Abstract The hyo-laryngeal complex is a multi-segmented structure integrating the oral and pharyngeal cavities and thus a variety of critical functions related to airway control, feeding, and vocal communication. Currently, we lack a complete understanding of how the hyoid complex, and the functions it mediates, can also be affected by changes in surrounding cranio-facial dimensions. Here, we explore these relationships in a breed of domestic dog, the Portuguese Water Dog, which is characterized by strong cranio-facial variation. We used radiographic images of the ... περισσότερα »
Antagonistic Effects of Insulin and TGF-β3 during Chondrogenic Differentiation of Human BMSCs under a Minimal Amount of Factors
Antagonistic Effects of Insulin and TGF-β3 during Chondrogenic Differentiation of Human BMSCs under a Minimal Amount of Factors: Growth factors are crucial regulators of cell differentiation towards tissue and organ development. Insulin and transforming growth factor-β (TGF-β) have been used as the major factors for chondrogenesis in vitro, by activating the AKT and Smad signaling pathways. Previous reports demonstrated that AKT and Smad3 have a direct interaction that results in the inhibition of TGF-β-mediated cellular responses. However, the result of this interaction between AKT... περισσότερα »
Don't forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices.
Don't forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices.:
Don't forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices.
Don't forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices.:
The ultrasound-guided transversus thoracic muscle plane block is effective for the median sternotomy
The ultrasound-guided transversus thoracic muscle plane block is effective for the median sternotomy: An ultrasound-guided transversus thoracic muscle plane (TTP) block has been reported for a few years [1, 2]. TTP block can be blocked anterior branches of intercostal nerves (Th2-6). Therefore, we think that thoracic muscle plane block is effective for the median sternotomy. We report two cases of median sternotomy performed with the TTP block. Case 1 was an 84-year-old man with hypertension and aortic stenosis who underwent aortic valve replacement. Considering the efficacy of the ... περισσότερα »
Jaw closure using an air-inflatable pneumatic actuator device can produce substantial decreases in upper airway collapsibility and maintain upper airway patency during propofol anesthesia
A pilot study of upper airway management using a remote-controlled artificial muscle device during propofol anesthesia: [image: gr1.sml] To test the hypothesis that the jaw closure using a pneumatic actuator device affect airway collapsibility and resistance during propofol anesthesia. Highlights - •We examine the effect of air-inflatable artificial muscle device on jaw closure. - •The jaw closure can improve upper airway collapsibility under propofol anesthesia. - •This finding is relevant to managing upper airway patency during anesthesia with spontaneou... περισσότερα »
Upper airway management using a remote-controlled artificial muscle device during propofol anesthesia
A pilot study of upper airway management using a remote-controlled artificial muscle device during propofol anesthesia: [image: gr1.sml] To test the hypothesis that the jaw closure using a pneumatic actuator device affect airway collapsibility and resistance during propofol anesthesia. Highlights - •We examine the effect of air-inflatable artificial muscle device on jaw closure. - •The jaw closure can improve upper airway collapsibility under propofol anesthesia. - •This finding is relevant to managing upper airway patency during anesthesia with spontaneou... περισσότερα »
Hyperalgesia in Neuropathic Pain.
A Comparison of the Effects of Burst and Tonic Spinal Cord Stimulation on Hyperalgesia and Physical Activity in an Animal Model of Neuropathic Pain.: BACKGROUND: Parameters of spinal cord stimulation (SCS) play a role in its effectiveness and may impact SCS mechanisms and outcomes. For example, SCS applied in a bursting pattern may result in better pain relief than that for tonic SCS for neuropathic pain. We tested the effectiveness of different SCS pulse frequencies given at 2 different burst frequencies in an animal model of neuropathic pain. METHODS: After Sprague-Dawley rats were...περισσότερα »
Dermatopathology Fellowship
Characterization of Dermatopathology Fellowship Applicants: A 5-Year Single Institution Experience: Abstract *Background* Although much data has been documented on the characteristics of medical school applicants for dermatology and pathology residency programs in the United States and select medical and surgical fellowship applicants through the National Residency Matching Program (NRMP), little is known about the dermatopathology applicant demographics. *Methods* We examined a 5-year pool of dermatopathology fellowship applicants from a single institution (University of Arkansas f... περισσότερα »
Peritumoral and intratumoral budding in esophageal adenocarcinomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Impact of via Human Pathology Publication date: Available online 10 February 2016 *Source:*Human Pathology Author(s): Svenja Thies, Lars Guldener, Julia Slotta-Huspenina, Inti Zlobec, Viktor H. Koelzer, Alessandro Lugli, Dino Kröll, Christian A. Seiler, Marcus Feith, Rupert Langer Tumor budding has prognostic significance in many carcinomas and is defined as the presence of detached isolated single cells or small cell clusters up to five cells at the invasion front (peritumoral budding=PTB) or within the tumor (intratumoral budding=ITB). For esophageal adenocarcinomas (EAC) there are...περισσότερα »
Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern: [image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] ABSTRACT Neoplasms with myopericytomatous pattern represent a morphological spectrum of lesions encompassing myopericytoma of the skin and soft tissue, angioleiomyoma, myofibromatosis/infantile haemangiopericytoma and putative neoplasms reported as malignant myopericytoma. Lack of reproducible phenotypic and genetic features of malignant myopericytic neoplasms preven... περισσότερα »
Erythromycin in Trauma Patients with a Full Stomach
Ultrasound Assessment of the Prokinetic Effect of Erythromycin in Trauma Patients with a Full Stomach: A Case Series.: In this preliminary prospective noninterventional study, we assessed the prokinetic effect of 3 mg*kg-1 erythromycin in nonfasted emergency trauma patients. Ultrasonographic measurements of the antral area were performed 30 minutes and immediately before the erythromycin infusion and serially at 30, 60, and 90 minutes after the start of the infusion. Gastric emptying rates before and after erythromycin infusion, and at each 30-minute period after erythromycin infusi... περισσότερα »
Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials.
Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials.: BACKGROUND: Patient memories of the operating room (OR) may serve as the informational basis for assessing satisfaction with individual anesthesiologists. Furthermore, the provision of clinically important information may assume that perioperative memories are retained. Studies assessing the extent of perioperative amnesia and factors associated with perioperative amnesia are sparse. Therefore, we assessed patient amnesia of the OR and of the preoperative holding area in hospitals where midazolam is typi...περισσότερα »
Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury
Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway.: BACKGROUND: Phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) pathway activation may promote neuronal survival via neuroprotection during inflammation after cerebral ischemia. In this study, we investigated whether IV pretreatment with emulsified isoflurane (EI) could decrease ischemic brain injury related to the PI3K/Akt pathway. METHODS: Male Sprague-Dawley rats received different doses of IV EI (1, 2, 4, or 8 mL/kg/h) or Intralipid(R) (8 mL/kg/h) for 3... περισσότερα »
Postoperative Blood Pressure and Pain Subsequent to Craniotomy
Effects of an Intraoperative Dexmedetomidine Bolus on the Postoperative Blood Pressure and Pain Subsequent to Craniotomy for Supratentorial Tumors.: Background: Control of emergence hypertension and pain is important after craniotomy for monitoring the neurological status. This prospective double-blinded study investigated the hemodynamics after a single bolus of dexmedetomidine (DEX) infusion administered to the patient undergoing craniotomy under general anesthesia, and its effect on emergence hypertension and postsurgical pain. Methods: Adult patients scheduled for elective surger... περισσότερα »
Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia
Aldose reductase (AR; gene *AKR1B1*) is the rate-limiting enzyme of the polyol pathway and has been associated with diabetes and atherosclerosis. Here, we sought to identify the mechanisms underlying differential AR expression in human atherosclerotic plaque macrophages. *In vitro*, M1-polarized human monocyte-derived macrophages expressed significantly higher levels of *AKR1B1* mRNA and AR protein compared with M2-polarized macrophages. AR activity was significantly higher in M1 macrophages. *AKR1B1* mRNA expression correlated positively with the M1 marker *TNF* (*r* = 0.430, *P*...περισσότερα »
Serotype O:8 isolates in the Yersinia pseudotuberculosis complex have different O-antigen gene clusters and produce various forms of rough LPS
In *Yersinia pseudotuberculosis* complex, the O-antigen of LPS is used for the serological characterization of strains, and 21 serotypes have been identified to date. The O-antigen biosynthesis gene cluster and corresponding O-antigen structure have been described for 18, leaving O:8, O:13 and O:14 unresolved. In this study, two O:8 isolates were examined. The O-antigen gene cluster sequence of strain 151 was near identical to serotype O:4a, though a frame-shift mutation was found in *ddhD*, while No. 6 was different to 151 and carried the O:1b gene cluster. Structural analysis re... περισσότερα »
Ultrasound-guided right infraclavicular proximal axillary venous catheterization
Influence of arm position on catheter placement during real-time ultrasound-guided right infraclavicular proximal axillary venous catheterization: Background Real-time ultrasound-guided infraclavicular proximal axillary venous catheterization is used in many clinical situations and provides the advantages of catheter stabilization, a reduced risk of catheter-related infection, and comfort for the patient without limitation of movement. However, unintended catheter tip dislocation and accidental arterial puncture occur occasionally. This study was designed to investigate the influen... περισσότερα »
The simulation of facemask ventilation, direct laryngoscopy and tracheal intubation
Suitability of a preserved human cadaver model for the simulation of facemask ventilation, direct laryngoscopy and tracheal intubation: a laboratory investigation: Background Using fresh or formalin-embalmed cadavers has not been generally accepted for the purposes of teaching airway management. We investigated whether cadavers ‘preserved according Thiel's embalming method’ (PATEM) are suitable for the simulation of facemask ventilation and tracheal intubation by direct laryngoscopy. Methods This observational cluster sampling, controlled simulation study, included eight PATEM cad...περισσότερα »
Screening of perioperative stroke in general surgery
Clinical diagnostic tools for screening of perioperative stroke in general surgery: a systematic review: Perioperative stroke is a devastating complication that carries high mortality and functional disability. Unfortunately, residual anaesthesia and analgesia may obscure important warning signs and may lead to a delay in the assessment and treatment of major stroke after surgery. The purpose of this review is to examine the utility of existing stroke scales, for the recognition of perioperative stroke in the general surgical population. A total of 21 stroke scales have been descri... περισσότερα »
Determining the insertion depth of tracheal tubes in children
A new method for determining the insertion depth of tracheal tubes in children: a pilot study: Background Choosing the correct insertion depth of tracheal tubes is crucial for successful airway management in paediatrics. Currently used formulas are based on patient characteristics such as age, body weight and height. The aim of the study is to devise and evaluate more suitable body surface area based diagrams for predicting the correct tracheal insertion depth. Methods Calculated insertion depth according to currently used formulas, primary insertion depth and insertion depth corre... περισσότερα »
Cricoid pressure impedes tracheal intubation with the Pentax-AWS Airwayscope(R): a prospective randomized trial
Cricoid pressure impedes tracheal intubation with the Pentax-AWS Airwayscope(R): a prospective randomized trial: Background It is unclear how cricoid pressure affects tracheal intubation with the Pentax-AWS Airwayscope® (AWS). We conducted a prospective randomized clinical trial in anaesthetized patients. Methods Sixty patients were allocated to either the cricoid pressure (CP) group (*n*=30) or the sham group (*n*=30). We compared the two groups with regard to intubation time, number of attempts required for insertion of the Intlock blade (disposable blade of the AWS) and tracheal...περισσότερα »
Sexual health risks, service use, and views of rapid point-of-care testing among men who have sex with men attending saunas: a cross-sectional survey
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Guidelines highlight the need to increase HIV testing among men who have sex with men (MSM) and novel point-of-care testing provides new possibilities for delivery of care. However, it is unclear how point-of-care testing should be used to best effect. This study aimed to increase understanding of sexual risk-taking behaviour, service use, and attitudes to […]
Osseointegrated Dental Fibula Free Flaps for Mandibular Reconstruction
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Osseointegrated Dental Fibula Free Flaps for Mandibular Reconstruction: This study evaluates the clinical outcomes and success rates of primary and secondary dental implant placement in vascularized fibula bone grafts used for segmental mandibulectomy defects. Importance Dental implantation has been used for oral rehabilitation to improve cosmesis and function. Objective We aim to evaluate the clinical […]
Optimal Columellar Strut Dimensions for Nasal Tip Stabilization
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Optimal Columellar Strut Dimensions for Nasal Tip Stabilization: This study uses computer-generated models of the human nose to determine the effect of the columellar strut graft on nasal tip support and to identify how suture placement contributes to tip support. Importance The contribution of columellar strut grafts (CSGs) to nasal tip support has not been […]
Radiological input during paediatric multidisciplinary team meetings and its influence on clinical patient management
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Abstract Introduction There is little information about the role of the radiologist at multidisciplinary team meetings; in particular their influence on patient management. To evaluate the influence of radiologists on clinical patient management during multidisciplinary meetings. Methods Prospective data were collected over a 5-week period from multidisciplinary team meetings across four paediatric clinical domains. Radiological […]
18F-FDG PET–CT performed before and during radiation therapy of head and neck squamous cell carcinoma: Are they independent or complementary to each other?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Abstract Introduction The aims of this study are to evaluate the prognostic value of metabolic parameters derived from 18F-FDG PET-CT performed before definitive radiation therapy (RT) (prePET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC) and to assess the additive prognostic values of FDG PET-CT performed during RT (iPET). Methods One […]
Development of a more streamlined approach to pregnancy screening before nuclear medicine procedures
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mw4CNa via IFTTT
Prevalence and associated factors of HIV infection among men who have sex with men in Hefei, China, 2013-2014: a cross-sectional study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
The objective of this study was to investigate the prevalence and influencing factors of HIV infection among men who have sex with men (MSM) in Hefei, China. A total of 578 MSM were recruited, with a mean age of 28.13 ± 6.91; 70.7% were under 30. The awareness rate was 95.4% (560/587) in the cross-sectional […]
Mycoplasma genitalium: a possible case of macrolide resistance from Lebanon
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Lkkc5h via IFTTT
Sex workers, condoms, and mobility among men in Uzbekistan: implications for HIV transmission
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Uzbekistan has one of the fastest growing HIV epidemics in the world. In this study, men who reported mobility were compared to non-mobile men in regard to paying for sex and condom use during paid sex. The sample included 2333 men between the ages of 15 and 59 in Uzbekistan. Generalised linear models were used […]
Ineffective central nervous system HIV suppression of once-a-day maraviroc and ritonavir-boosted darunavir dual therapy: four case reports
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Novel two-drug combinations including a protease inhibitor are an attractive nucleoside reverse transcriptase inhibitor sparing option for some patients, particularly as a switch strategy. We have used the two-drug combination of maraviroc and darunavir/ritonavir once a day as a switch strategy in patients with stable low or undetectable plasma HIV viral loads, but identified four […]
Dexmedetomidine post-treatment induces neuroprotection via activation of extracellular signal-regulated kinase in rats with subarachnoid haemorrhage
Dexmedetomidine post-treatment induces neuroprotection via activation of extracellular signal-regulated kinase in rats with subarachnoid haemorrhage: Background Dexmedetomidine, a sedative agent, provides neuroprotection when administered during or before brain ischaemia. This study was designed to determine whether dexmedetomidine post-treatment induces neuroprotection against subarachnoid haemorrhage (SAH) and the mechanisms for this effect. Methods Subarachnoid haemorrhage was induced by endovascular perforation to the junction of the right middle and anterior cerebral arteries ...περισσότερα »
Fibre-optic intubation
Simulation as a set-up for technical proficiency: can a virtual warm-up improve live fibre-optic intubation?: Background Fibre-optic intubation (FOI) is an advanced technical skill, which anaesthesia residents must frequently perform under pressure. In surgical subspecialties, a virtual ‘warm-up’ has been used to prime a practitioner's skill set immediately before performance of challenging procedures. This study examined whether a virtual warm-up improved the performance of elective live patient FOI by anaesthesia residents. Methods Clinical anaesthesia yr 1 and 2 (CA1 and CA2) re... περισσότερα »
Emergence delirium or pain after anaesthesia
Emergence delirium or pain after anaesthesia--how to distinguish between the two in young children: a retrospective analysis of observational studies: Background Early postoperative negative behaviour in preschool children after general anaesthesia is a common problem. The distinction between emergence delirium (ED) and pain is difficult, but management differs between the two. The aim of the current analysis was to identify individual observational variables that can be used to diagnose ED and allow distinction from postoperative pain. Methods This retrospective analysis of data ... περισσότερα »
Ultrasound guided internal jugular venous cannulation
Randomized comparison of three transducer orientation approaches for ultrasound guided internal jugular venous cannulation: Background Ultrasound-guided internal jugular venous access increases the rate of successful cannulation and reduces the incidence of complications, compared with the landmark technique. Three transducer orientation approaches have been proposed for this procedure: short-axis (SAX), long-axis (LAX) and oblique-axis (OAX). Our goal was to assess and compare the performance of these approaches. Methods A prospective randomized clinical trial was conducted in one...περισσότερα »
Qualität der Schmerztherapie
Qualität der Schmerztherapie in Deutschland – Organisation der Akutschmerztherapie: Leitlinien, Empfehlungen und aktuelle Praxis: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 40-48 DOI: 10.1055/s-0041-101757 Organisatorische Voraussetzungen und die Aus- und Weiterbildung von Klinikmitarbeitern schaffen die Basis für eine adäquate Versorgungsqualität der Akutschmerztherapie und sollten im Fokus der Bemühungen stehen. Obwohl organisatorische Empfehlungen der S3- Leitlinie zur „Behandlung akuter perioperativer und posttraumatischer Schmerzen“ in der vergangenen Jahren zune... περισσότερα »
Ultrasound imaging of the joint damage in the patient with long-standing Rheumatoid Arthritis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
LETTER Hippokratia 2015, 19(3):281 Kakavouli GG1, Siagkri C1, Zivanovic S2 1Rheumatologist in private practice, Greece, 2Rheumatology Department, University of Kragujevac, Kragujevac, Serbia from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kf139O via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The role of Apigenin in testicular damage in experimental ischemia-reperfusion injury in rats
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
ORIGINAL ARTICLE Hippokratia 2015, 19(3):225-230 Skondras I1, Lambropoulou M2, Tsaroucha A3, Gardikis S1, Tripsianis G4, Simopoulos C3, Vaos G1 1Department of Pediatric Surgery, 2Laboratory of Histology, 32nd Department of Surgery and Laboratory of Experimental Surgery, 4Laboratory of Medical Statistics Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QaLHiH […]
Recurrent pneumothorax in a pregnant woman with a family history of spontaneous pneumothorax
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
LETTER Hippokratia 2015, 19(3):287 Liberis A, Tsikouras P, Liberis V Department of Obstetrics and Gynecology, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kf10L9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Investigating the role of Natural Killer T-cells in Gram negative infections of patients with type 2 diabetes mellitus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
ORIGINAL ARTICLE Hippokratia 2015, 19(3):231-234 Karagianni P¹, Polyzos SA ¹, Bougiouklis D², Tsapas A¹, Paletas K³ ¹Second Internal Medicine Department, Hippokratio General Hospital, Aristotle University of Thessaloniki ²Hematology Department, Theagenion Hospital, ³Internal Medicine Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QaLJaf via IFTTT Medicine by Alexandros […]
Fatal uremic leontiasis ossea in long-lasting uncontrolled hyperparathyroidism: a case report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
CASE REPORT Hippokratia 2015, 19(3):266-267 Dimkovic N1,2, Piscevic V2, Jankovic A3, Djuric P3 1Medical Faculty, University of Belgrade, 2 Department for Physical Medicine and Rehabilitation, Zvezdara University Medical Center, 3Clinical Department for Renal Diseases, Zvezdara University Medical Center, Belgrade, Serbia from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kf10uL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios […]
The Patient State Index is well balanced for propofol sedation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
ORIGINAL ARTICLE Hippokratia 2015, 19(3):235-238 Lee KH1, Kim YH1, Sung YJ1, Oh MK2 1Department of Anesthesiology and Pain Medicine of Haeundae Paik Hospital, 2Clinical Trial Center of Busan Paik Hospital, Busan, Korea from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QaLITK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Percutaneous stenting of a dissected superior mesenteric artery in a patient with previous surgical repair of Stanford type A aortic dissection.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
CASE REPORT Hippokratia 2015, 19(3):270-273 Hatzidakis A1, Krokidis M2, Androulakakis Z3, Rossi M4 1Department of Radiology, University Hospital Heraklion, Medical School of Crete, Heraklion, Greece, 2Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, 3Vascular Surgeon, Heraklion, Greece, 4Interventional Radiology Unit, S. Andrea University Hospital, Rome, Italy from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader […]
Establishing cross-sectional curves for height, weight, body mass index and waist circumference for 4- to 18-year-old Greek children, using the Lambda Mu and Sigma (LMS) statistical method
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
ORIGINAL ARTICLE Hippokratia 2015, 19(3):239-248 Tambalis KD1, Panagiotakos DB1, Arnaoutis G1, Psarra G1, Maraki M1, Mourtakos S1, Grigorakis D1, Sidossis LS1,2 1Department of Nutrition and Dietetics, Harokopio University, Athens, Greece, 2Department of Internal Medicine, Sealy Center on Aging, Institute for Translational Sciences and Shriners Hospital for Children, University of Texas Medical Branch at Galveston, Texas, […]
Dissection of the right coronary artery following blunt cardiac injury
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
CASE REPORT Hippokratia 2015, 19(3):278-280 Vogiatzis I, Dapcevic I Department of Cardiology, General Hospital of Veroia, Veroia, Greece from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kf10e4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The effect of sorafenib on liver regeneration and angiogenesis after partial hepatectomy in rats
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
ORIGINAL ARTICLE Hippokratia 2015, 19(3):249-255 Kiroplastis K1, Fouzas I2,Katsiki E3, Patsiaoura K3, Daoudaki M2, Komninou A4, Xolongitas E2, Katsika E2, Kaidoglou K5, Papanikolaou V2 5th Surgical Department, Aristotle University of Thessaloniki, Hippokratio General Hospital, 2Division of Transplantation, Department of Surgery, Aristotle University of Thessaloniki, Hippokratio General Hospital, 3Department of Pathology, Hippokratio General Hospital, 4School of […]
Osseointegrated Dental Fibula Free Flaps for Mandibular Reconstruction
Osseointegrated Dental Fibula Free Flaps for Mandibular Reconstruction: This study evaluates the clinical outcomes and success rates of primary and secondary dental implant placement in vascularized fibula bone grafts used for segmental mandibulectomy defects. *Importance* Dental implantation has been used for oral rehabilitation to improve cosmesis and function. *Objective* We aim to evaluate the clinical outcomes and success rates of primary and secondary dental implant placement in vascularized fibula bone grafts used for segmental mandibulectomy defects. *Design, Setting, an...περισσότερα »
Optimal Columellar Strut Dimensions for Nasal Tip Stabilization
Optimal Columellar Strut Dimensions for Nasal Tip Stabilization: This study uses computer-generated models of the human nose to determine the effect of the columellar strut graft on nasal tip support and to identify how suture placement contributes to tip support. *Importance* The contribution of columellar strut grafts (CSGs) to nasal tip support has not been determined via structural mechanics. Optimal graft dimensions have yet to be objectively determined. *Objectives* To use a finite element model (FEM) of the human nose to (1) determine the effect of the CSG on nasal tip su... περισσότερα »
Nerve transfer for cervical spinal cord injury
Increasing the availability of nerve transfer for cervical spinal cord injury: We are hand surgeons interested in developing reconstructive upper limb services for patients with cervical spinal cord injury (CSCI). CSCI is a catastrophic traumatic injury that frequently results in devastating loss of upper limb function. Patients have been shown to rank restoration of hand function above bladder, bowel, sexual function as well as chronic pain1-3. Selective nerve fascicle transfer offers an opportunity to restore prehensile grip with limited loss of donor muscle innervation and minimal... περισσότερα »
Infantile Hemangiomas in Twins: A Prospective Cohort Study
Infantile Hemangiomas in Twins: A Prospective Cohort Study: Abstract Background Twins have a higher-than-expected risk of infantile hemangiomas (IHs), but the exact reasons for this association are not clear. Comparing concordant and discordant twin pairs might help elucidate these factors and yield more information about IH risk factors. Methods A prospective cohort study of twin pairs from 12 pediatric dermatology centers in the United States, Canada, Argentina, and Spain was conducted. Information regarding maternal pregnancy history, family history of vascular birthmarks, zygosi...περισσότερα »
Prediction of Stent-Retriever Thrombectomy Outcomes by Dynamic Multidetector CT Angiography in Patients with Acute Carotid T or MCA Occlusions [ADULT BRAIN]
BACKGROUND AND PURPOSE: The selection of patients for endovascular therapy is an important issue in stroke imaging. The aim of this study was to determine the predictive value of 3 different dynamic CT angiography parameters, occlusion length, collateralization extent, and time delay to maximum enhancement, for latest generation of stent retriever thrombectomy recanalization outcomes in patients with acute ischemic stroke. MATERIALS AND METHODS: In this study, subjects were selected from an initial cohort of 2059 consecutive patients who had undergone multiparametric CT, includi...περισσότερα »
Differentiating Pediatric Rhabdomyosarcoma and Langerhans Cell Histiocytosis of the Temporal Bone by Imaging Appearance [HEAD & NECK]
BACKGROUND AND PURPOSE: Rhabdomyosarcoma and Langerhans cell histiocytosis are malignant lesions that can affect the skull base with similar radiographic characteristics on CT and MR imaging. We hypothesized that location within the temporal bone determined radiographically can provide useful adjunctive information in differentiating these distinct neoplasms. MATERIALS AND METHODS: We identified patients with Langerhans cell histiocytosis and rhabdomyosarcoma by using an imaging data base and International Classification of Diseases, Ninth Revision codes at a tertiary care acad... περισσότερα »
Evaluation for Blunt Cerebrovascular Injury: Review of the Literature and a Cost-Effectiveness Analysis [ADULT BRAIN]
BACKGROUND AND PURPOSE: Evaluation for blunt cerebrovascular injury has generated immense controversy with wide variations in recommendations regarding the need for evaluation and the optimal imaging technique. We review the literature and determine the most cost-effective strategy for evaluating blunt cerebrovascular injury in trauma patients. MATERIALS AND METHODS: A comprehensive literature review was performed with data extracted to create a decision-tree analysis for 5 different strategies: anticoagulation for high-risk (based on the Denver screening criteria) patients, sel... περισσότερα »
Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment? [ADULT BRAIN]
BACKGROUND AND PURPOSE: Autosomal dominant polycystic kidney disease is associated with an increased risk of intracranial aneurysms. Our purpose was to assess whether there is an increased risk during aneurysm coiling and clipping. MATERIALS AND METHODS: Data were obtained from the National Inpatient Sample (2000–2011). All subjects had an unruptured aneurysm clipped or coiled and were divided into polycystic kidney (*n* = 189) and control (*n* = 3555) groups. Primary end points included in-hospital mortality, length of stay, and total hospital charges. Secondary end points incl...περισσότερα »
Increasing the availability of nerve transfer for cervical spinal cord injury
Publication date: Available online 12 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Joseph Ward, Dominic Power from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1SkVjxD via IFTTT
Immediate breast reconstruction with a myocutaneous latissimus dorsi flap and implant following skin sparing salvage mastectomy after irradiation as part of breast conserving therapy
Publication date: Available online 11 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Martine A. van Huizum, J.Joris Hage, Emiel J. Rutgers, Marije J. Hoornweg BackgroundLocal relapse after breast conserving therapy including whole breast irradiation is usually treated by salvage mastectomy. Immediate reconstruction by pedicled transfer of a latissimus dorsi flap in combination with implantation of a definitive prosthesis or temporary tissue expander has been shown feasible. However, it has never been shown to be justifiable.PurposeTo compare... περισσότερα »
Refinements in dynamic external fixation for optimal fracture distraction in pilon-type fractures of the proximal interphalangeal joint
Publication date: Available online 12 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Dariush Nikkhah, Julia Ruston, Neil Toft from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1SkVhpC via IFTTT
Role of Sirolimus in Advanced Kaposiform Hemangioendothelioma
Role of Sirolimus in Advanced Kaposiform Hemangioendothelioma: Abstract Kaposiform hemangioendothelioma (KHE) is an infiltrative vascular tumor that classically presents in infancy. Management typically focuses on treating Kasabach–Merritt phenomenon (KMP), a disorder of severe and at times life-threatening platelet trapping. However, the morbidity of KHE extends beyond KMP. The infiltrative nature of the tumor can lead to long-term disability and often makes complete surgical resection impossible. We report the case of a 10-year-old boy with a KHE of his right distal thigh who was... περισσότερα »
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom)
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom): Abstract*Ganoderma lucidum* (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for over 2000 years. Studies have shown that *G. lucidum* has anti-allergic, anti-oxidant, anti-tumor, anti-viral, and anti-inflammatory properties. A review of the literature revealed that there were no studies examining the use of *G. lucidum* for the treatment of skin diseases. Here, we report the case of a 44-year-old male patient who used soap enriche...περισσότερα »
Genetics of circadian rhythms and bipolar disorder [Genetics]
Genetics of circadian rhythms and bipolar disorder [Genetics]: Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian...
Speech and developmental delay, microcephaly, and mild ventriculomegaly : Prenatal detection of 5q14.3 duplication including MEF2C and brain phenotype
Prenatal detection of 5q14.3 duplication including MEF2C and brain phenotype: The 5q14.3 duplication is a rare condition comprising speech and developmental delay, microcephaly, and mild ventriculomegaly. The region 5q14.3 contains several genes but the predominant role for the onset of the neurodevelopmental phenotype has been attributed to *MEF2C*. We describe the prenatal identification of 5q14.3 duplication, including *MEF2C*, in a monochorionic twin pregnancy with corpus callosum anomalies, confirmed by autopsy. To the best of our knowledge, this cerebral finding has been obs... περισσότερα »
Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model
Abstract Ginsenoside Rg1 has been demonstrated to have cardiovascular protective effects. However, whether the cardioprotective effects of ginsenoside Rg1 are mediated by endoplasmic reticulum (ER) stress-induced apoptosis remain unclear. In this study, among 80 male Wistar rats, 15 rats were randomly selected as controls; the remaining 65 rats received a diet rich in fat and sugar content for 4 weeks, followed by intraperitoneal injection of streptozotocin (STZ, 40 mg/kg) to establish a diabetes model. Seven days after STZ injection, 10 rats were randomly selected as diabetic mode...περισσότερα »
Software for Genome-wide association studies (GWAS)
Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data: Genome-wide association studies (GWAS) have associated many single variants with complex disease, yet the better part heritable complex disease risk remains unexplained. Analytical tools designed to work under specific population genetic models are needed. Rare variants are increasingly shown to be important in human complex disease, but most existing GWAS data do not cover rare variants. Explicit population genetic models predict that genes contributing to complex traits and experiencing recurrent, unconditio...περισσότερα »
A distinctive facial appearance, intellectual disability, and increased height : Tatton–Brown–Rahman syndrome due to 2p23 microdeletion
Tatton–Brown–Rahman syndrome due to 2p23 microdeletion: Tatton–Brown–Rahman syndrome is a new overgrowth syndrome due to *DNMT3A* (DNA cytosine 5 methyltransferase 3A) mutations. Mutation carriers show a distinctive facial appearance, intellectual disability, and increased height. We report a patient with overgrowth who showed submicroscopic deletion of chromosome 2p23 including *DNMT3A*. The deletion was detected by array-CGH. He showed moderate ID and distinctive facial gestalt. His clinical features were consistent with those of Tatton–Brown–Rahman syndrome. We suggest that 2p23... περισσότερα »
The Oct1 transcription factor and epithelial malignancies
: Old protein learns new tricks via http://rss.sciencedirect.com/publication/science/18749399 Publication date: Available online 10 February 2016 *Source:*Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Author(s): Karina Vázquez-Arreguín, Dean Tantin The metazoan-specific POU domain transcription factor family comprises activities underpinning developmental processes such as embryonic pluripotency and neuronal specification. Some POU family proteins efficiently bind an 8-bp DNA element known as the octamer motif. These proteins are known as Oct. transcription factors. O... περισσότερα »
A newborn boy with asphyxia, narrow thorax, and severe hypotonia : Shwachman–Diamond–Bodian syndrome (SDS)
Novel myopathy in a newborn with Shwachman–Diamond syndrome and review of neonatal presentation: Shwachman–Diamond–Bodian syndrome (SDS) is a pleiotropic disorder in which the main features are bone marrow dysfunction and pancreatic insufficiency. Skeletal changes can occur, and in rare cases manifest as severe congenital thoracic dystrophy. We report a newborn boy with asphyxia, narrow thorax, and severe hypotonia initially suggesting a neuromuscular disease. The muscle biopsy showed myopathic changes with prominent variability in muscle fiber size and abnormal expression of devel... περισσότερα »
Spectral contrast enhancement improves speech intelligibility in noise for cochlear implants
Spectral contrast enhancement improves speech intelligibility in noise for cochlear implants: Spectral smearing causes, at least partially, that cochlear implant(CI) users require a higher signal-to-noise ratio to obtain the same speech intelligibility as normal hearing listeners. A spectral contrast enhancement (SCE) algorithm has been designed and evaluated as an additional feature for a standard CI strategy. The algorithm keeps the most prominent peaks within a speech signal constant while attenuating valleys in the spectrum. The goal is to partly compensate for the spectral sme... περισσότερα »
ASGE Technology Committee systematic review and meta-analysis assessing the ASGE Preservation and Incorp oration of Valuable Endoscopic Innovations thresholds for adopting real-time imaging–assisted endoscopic targeted biopsy during endoscopic surveillance of Barrett’s esophagus
Publication date: Available online 11 February 2016 *Source:*Gastrointestinal Endoscopy Author(s): Nirav Thosani, Barham K. Abu Dayyeh, Prateek Sharma, Harry R. Aslanian, Brintha K. Enestvedt, Sri Komanduri, Michael Manfredi, Udayakumar Navaneethan, John T. Maple, Rahul Pannala, Mansour A. Parsi, Zachary L. Smith, Shelby A. Sullivan, Subhas Banerjee Background and AimsEndoscopic real-time imaging of Barrett's esophagus (BE) with advanced imaging technologies enables targeted biopsies and may eliminate the need for random biopsies to detect dysplasia during endoscopic surveillance of... περισσότερα »
Lack of Dystrophin Affects Bronchial Epithelium in mdx Mice
Abstract Mild exercise training may positively affect the course of Duchenne Muscular Dystrophy (DMD). Training causes mild bronchial epithelial injury in both humans and mice, but no study assessed the effects of exercise in *mdx* mice, a well known model of DMD. The airway epithelium was examined in *mdx* (C57BL/10ScSn-Dmdmdx) mice, and in wild type (WT, C57BL/10ScSc) mice either under sedentary conditions (*mdx*-SD, WT-SD) or during mild exercise training (*mdx*-EX, WT-EX). At baseline, and after 30 and 45 days of training (5 d/wk for 6 weeks), epithelial morphology and markers ...περισσότερα »
Phosphorylation Regulates Functions of ZEB1 Transcription Factor
SUMMARY ZEB1 transcription factor is important in both development and disease, including many TGFβ-induced responses, and the epithelial-to-mesenchymal transition (EMT) by which many tumors undergo metastasis. ZEB1 is differentially phosphorylated in different cell types; however the role of phosphorylation in ZEB1 activity is unknown. Luciferase reporter studies and electrophoresis mobility shift assays (EMSA) show that a decrease in phosphorylation of ZEB1 increases both DNA-binding and transcriptional repression of ZEB1 target genes. Functional analysis of ZEB1 phosphorylation... περισσότερα »
INTERVENTIONAL MOLECULAR IMAGING
While Molecular Imaging has had a dramatic impact on Diagnostic Imaging, it has only recently begun to be integrated into interventional procedures. Its significant impact is attributed to its ability to provide non-invasive, physiologic information that has supplemented conventional morphologic imaging. The four major interventional opportunities for Molecular Imaging are to first, provide guidance to localize a target; second, provide tissue analysis to confirm that the target has been reached; third, provide in-room, post-therapy assessment; and fourth, deliver targeted therape... περισσότερα »
microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models
Abnormal accumulation of tau aggregates in brain is one of the hallmarks of Alzheimer's disease neuropathology. We visualized tau deposition in vivo with the previously developed 2-arylquinoline derivative 18F-THK5117 using small animal positron-emission-tomography (µPET) in conjunction with autoradiography and immunohistochemistry gold standard assessment in two transgenic mouse models expressing hyperphosphorylated tau. µPET recordings were obtained in groups of P301S (*N* = 11) and biGT mice (*N* = 16) of different ages, with age-matched wild-type (WT) serving as controls. After... περισσότερα »
Pretreatment 18FDG-PET Textural Features in Locally Advanced Non-Small Cell Lung Cancer: Secondary Analysis of ACRIN 6668/RTOG 0235
*Background:* In a secondary analysis of ACRIN 6668/RTOG 0235, high pretreatment metabolic tumor volume (MTV) on positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) was found to be a poor prognostic factor for patients treated with chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC). Here we utilize the same dataset to explore whether heterogeneity metrics based on PET textural features can provide additional prognostic information. *Methods:* Patients with locally advanced NSCLC underwent 18FDG-PET prior to treatment. A gradient-based segmenta...περισσότερα »
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent
Circulating Myeloid-Derived Suppressor Cells Predict Differentiated Thyroid Cancer Diagnosis and Extent: Thyroid , Vol. 0, No. 0. Author information Trevor E. Angell,1 Melissa G. Lechner,2 Alison M. Smith,3 Sue E. Martin,3 Susan G. Groshen,4 Dennis R. Maceri,5 Peter A. Singer,6 and Alan L. Epstein3 1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts. 2Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 3Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, Ca... περισσότερα »
EMS training
EMS training: Make the most of every opportunity: A few months ago, I attended some refresher training on the video laryngoscope that had recently been added to our department's protocols. Apparently a review of the PCR data showed that we weren’t using the VLs and that intubation rates had not improved. It was unclear whether or not that was because of an actual problem using the device or documentation errors, but the decision was made — correctly, in my opinion — to provide an in-service VL refresher to every ALS provider. Unfortunately, this opportunity, like many, was another ...περισσότερα »
Humane Papillomviren bei Plattenepithelkarzinomen der Kopf- und Halsregion
Humane Papillomviren bei Plattenepithelkarzinomen der Kopf- und Halsregion: ZusammenfassungHumane Papillomviren (HPV) verursachen bereits etwa die Hälfte aller Oropharynxkarzinome („oropharyngeal squamous cell carcinoma“, OPSCC) und die Neuerkrankungsrate HPV-assoziierter OPSCC steigt weiter stark an. Die virale Ursache ermöglicht die Entwicklung spezifischer diagnostischer, therapeutischer und prophylaktischer Verfahren. Die labortechnische Identifizierung eines HPV-assoziierten OPSCC kann durch die p16INK4a-Immunhistologie kombiniert mit einem HPV-DNA-Nachweis mittels Polymerasek... περισσότερα »
Quality of life in functional rhinoplasty: rhinoplasty outcomes evaluation German version (ROE-D)
Quality of life in functional rhinoplasty: rhinoplasty outcomes evaluation German version (ROE-D): AbstractThe aim of this study was to validate a German version of the rhinoplasty outcomes evaluation (ROE) questionnaire. A prospective study was conducted and a German translated ROE (ROE-D) questionnaire administered to 100 patients preoperatively, 6 and 12 months postoperatively. The translation was performed according to internationally accepted guidelines. To validate this instrument, we evaluated its reliability, validity and sensitivity. ROE-D was completed by 54 patients aft... περισσότερα »
Tracheostomie versus perkutane Dilatationstracheotomie
Tracheostomie versus perkutane Dilatationstracheotomie: ZusammenfassungZur Anlage eines Luftröhrenschnitts gibt es zurzeit viele Indikationen und unterschiedliche Vorgehensweisen. Die Regie im Rahmen einer interdisziplinären Indikationsstellung, bei der Auswahl des operativen Verfahrens, bei der Versorgung der tracheotomierten Patienten, insbesondere bei der Behandlung von typischen Problemen am Tracheostoma und von Komplikationen sollte beim HNO-Arzt liegen. Im Notfallmanagement stehen zunächst verschiedene nichtchirurgische Maßnahmen wie die Maskenbeatmung, die Intubation und ext... περισσότερα »
Four-Duct Ligation for the Treatment of Sialorrhea in Children
Four-Duct Ligation for the Treatment of Sialorrhea in Children: This retrospective cohort study reports clinical outcomes of the 4-duct ligation procedure in a consecutive series of pediatric patients with sialorrhea and characterizes patient and caregiver satisfaction. *Importance* The 4-duct ligation procedure has appeal for its surgical simplicity and limited invasiveness in the management of pediatric sialorrhea. However, more information is required to understand the benefits, risks, success rates, and long-term effects of this intervention. *Objectives* To report the clini... περισσότερα »
Rapidly Growing Vascular Mass Within the Thyroid
Rapidly Growing Vascular Mass Within the Thyroid: A woman with multinodular goiter was referred for exertional dyspnea and chest discomfort; CT revealed significant growth in a small time interval, and PET/CT was showed increased metabolic activity in the mass. What is your diagnosis? [image: First page PDF preview]
Quality Metrics and Survival in Oral Cavity Squamous Cell Carcinoma
Quality Metrics and Survival in Oral Cavity Squamous Cell Carcinoma: This cohort study examines whether compliance with various process-related quality metrics is associated with improved survival in patients with oral cavity squamous cell carcinoma who receive definitive surgery with or without adjuvant therapy. *Importance* Quality metrics for patients with head and neck cancer are available, but it is unknown whether compliance with these metrics is associated with improved patient survival. *Objective* To identify whether compliance with various process-related quality metr... περισσότερα »
The Zurich chronic middle ear inventory (ZCMEI-21)
Development and validation of the Zurich chronic middle ear inventory (ZCMEI-21): an electronic questionnaire for assessing quality of life in patients with chronic otitis media: AbstractBecause existing patient-reported outcome measures (PROMs) specific for chronic otitis media (COM) are lacking certain relevant symptoms and dimensions of health-related quality of life (HRQoL), we aimed to develop and validate a new questionnaire for comprehensively measuring HRQoL in adult patients with COM. An expert panel and patients were involved in developing the first version of the Zurich ... περισσότερα »
Radiological challenges in distinguishing keratocystic odontogenic tumor from ameloblastoma: an extraordinary occurrence in the same patient
Radiological challenges in distinguishing keratocystic odontogenic tumor from ameloblastoma: an extraordinary occurrence in the same patient: To describe the radiological appearance of two common odontogenic lesions (keratocystic odontogenic tumor and ameloblastoma) arising in the same patient simultaneously with their radiological differences and histological correlates, and to describe challenges in radiological diagnosis. *Abstract**Objectives* To describe the radiological appearance of two common odontogenic lesions (keratocystic odontogenic tumor and ameloblastoma) arising in...περισσότερα »
Preliminary Evaluation of Functional Swallow After Total Laryngectomy Using High-Resolution Manometry
Preliminary Evaluation of Functional Swallow After Total Laryngectomy Using High-Resolution Manometry: Introduction: Understanding of swallowing pressures after total laryngectomy (TL) and what constitutes a "functional" swallow are limited. Mobile structures are altered or removed after TL, with consequent effects on pressure profiles. High-resolution manometry (HRM) can characterize these pressures. Methods: Six TL subjects without dysphagia and 6 controls underwent pharyngeal HRM. Timing and pressure variables for the velopharynx, mesopharynx, and upper esophageal sphincter (UES...περισσότερα »
Agreement between health utility instruments in cochlear implantation
Agreement between health utility instruments in cochlear implantation: Objectives The objectives of our study were threefold: to compare health utility scores measured with different health utility instruments in adult patients with bilateral deafness, to compare the change in health utility scores after unilateral or bilateral cochlear implantation using the different health utility instruments and to assess which health utility instrument would be the most appropriate for future studies on cochlear implantation. Design A prospective study. Setting The data for this article were col... περισσότερα »
An anonymous Thirteenth Century lyric
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mw0Tzj via IFTTT
Incorporating Midbrain Adaptation to Mean Sound Level Improves Models of Auditory Cortical Processing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The Journal of Neuroscience from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qbnkri via IFTTT
The positive and negative consequences of stressors during early life
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Early Human Development from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mw0SeR via IFTTT
Idiosyncratic responding during movie-watching predicted by age differences in attentional control
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Neurobiology of Aging from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qbnjnn via IFTTT
A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
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