Effects of meditation practice on spontaneous eyeblink rate
[image: cover.gif?v=1&s=90bad8657ffbfb77a1508001] Abstract A rapidly growing body of research suggests that meditation can change brain and cognitive functioning. Yet little is known about the neurochemical mechanisms underlying meditation-related changes in cognition. Here, we investigated the effects of meditation on spontaneous eyeblink rates (sEBR), a noninvasive peripheral correlate of striatal dopamine activity. Previous studies have shown a relationship between sEBR and cognitive functions such as mind wandering, cognitive flexibility, and attention–functions that are also...περισσότερα »
Differential heart rate responses to social and monetary reinforcement in women with obesity
[image: cover.gif?v=1&s=90bad8657ffbfb77a1508001] Abstract Obesity is often accompanied by weight stigmatization; subsequently, individuals with obesity frequently face social rejection. It has been shown that recurrent negative social experiences can alter the perception of social cues. However, the way individuals with obesity process social stimuli is not well understood. This study aims to investigate obesity-related alterations in social compared to nonsocial information processing. Women with obesity (*n* = 14) and without obesity (*n* = 14) participated in a social and a m... περισσότερα »
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology via ScienceDirect Publication: Trends in Immunology Publication date: Available online 11 February 2016 *Source:*Trends in Immunology Author(s): Aleksandra Deczkowska, Kuti Baruch, Michal Schwartz Recent findings have revealed distinct roles for type I and II interferons (IFN-I and IFN-γ) in the recruitment of immune cells to the central nervous system (CNS) and highlighted the importance of this process for brain maintenance and protection/repair. Furthermore, manipulation of IFN-I and IFN-γ pathways in p...περισσότερα »
A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development
A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development: Humanized mice harboring human immune systems (HIS) represent a platform to study immune responses against pathogens and to screen vaccine candidates and novel immunotherapeutics. Innate and adaptive immune responses are suboptimal in HIS mice, possibly due to poor reconstitution of human antigen presenting cells, including dendritic cells (DCs). DC homeostasis is regulated by cytokine availability, and Flt3-ligand (Flt3L) is one factor that conditions this process. Mouse myelopoiesis is esse...περισσότερα »
TLR-Activated Gap Junction Channels Protects against Bacterial Infection
TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release [INFECTIOUS DISEASE AND HOST RESPONSE]: Extracellular UDP (eUDP), released as a danger signal by stressed or apoptotic cells, plays an important role in a series of physiological processes. Although the mechanism of eUDP release in apoptotic cells has been well defined, how the eUDP is released in innate immune responses remains unknown. In this study, we demonstrated that UDP was released in both *Escherichia coli*–infected mice and LPS- or Pam3CSK4-treated macrophages. ... περισσότερα »
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-{kappa}B
[IMMUNE REGULATION]: Arabinogalactan (AG) isolated from dust of a traditional farm prevents disease in murine models of allergy. However, it is unclear whether this polysaccharide has immune regulatory properties in humans. The aim of this study was to test the influence of AG on the immune-stimulating properties of human dendritic cells (DCs). Moreover, we sought to identify the receptor to which AG binds. AG was produced from plant callus tissue under sterile conditions to avoid the influence of pathogen-associated molecular patterns in subsequent experiments. The influence of AG...περισσότερα »
Swift and Strong NK Cell Responses Protects against High-Dose Influenza Virus Infection
Mice It is generally unclear what roles NK cells play during influenza virus infection with regard to different host genetic backgrounds. In this study, we show that in six inbred mouse strains, NK cells play an important protective role only in 129 mice during high-dose influenza A H1N1 virus infection. Swift and strong NK cell responses efficiently control early pulmonary viral replication in 129 mice, providing survival privilege. In addition, we identified that early activation of TLRs and RIG-I signaling in 129 mice resulted in quick production of type 1 IFNs and inflammator... περισσότερα »
Viral-Induced Demyelination : Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination
[INFECTIOUS DISEASE AND HOST RESPONSE]: The functional role of the ELR+ chemokine CXCL1 in host defense and disease following infection of the CNS with the neurotropic JHM strain of mouse hepatitis virus (JHMV) was examined. Mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein–positive cells were generated and this allowed for selectively increasing CNS expression of CXCL1 in response to JHMV infection and evaluating the effects on neuroinflammation, control of viral replication, and demyelination....περισσότερα »
Pro- and Anti-Inflammatory Role of ChemR23 Signaling in Pollutant-Induced Inflammatory Lung Responses
[INNATE IMMUNITY AND INFLAMMATION]: Inhalation of traffic-related particulate matter (e.g., diesel exhaust particles [DEPs]) is associated with acute inflammatory responses in the lung, and it promotes the development and aggravation of allergic airway diseases. We previously demonstrated that exposure to DEP was associated with increased recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in TH2 polarization. Monocytes and immature DCs express the G-protein coupled receptor chemR23, which binds the chemoattractant chemerin. Using chemR23 knock...περισσότερα »
p52 Overexpression Increases Epithelial Apoptosis
p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment [INNATE IMMUNITY AND INFLAMMATION]: Although numerous studies have demonstrated a critical role for canonical NF-B signaling in inflammation and disease, the function of the noncanonical NF-B pathway remains ill-defined. In lung tissue from patients with acute respiratory distress syndrome, we identified increased expression of the noncanonical pathway component p100/p52. To investigate the effects of p52 expression in vivo, we generated a novel transgeni...περισσότερα »
The Emerging Importance of IgG Fab Glycosylation in Immunity
The Emerging Importance of IgG Fab Glycosylation in Immunity [BRIEF REVIEWS]: Human IgG is the most abundant glycoprotein in serum and is crucial for protective immunity. In addition to conserved IgG Fc glycans, ~15–25% of serum IgG contains glycans within the variable domains. These so-called "Fab glycans" are primarily highly processed complex-type biantennary *N*-glycans linked to *N*-glycosylation sites that emerge during somatic hypermutation. Specific patterns of Fab glycosylation are concurrent with physiological and pathological conditions, such as pregnancy and rheumatoid ...περισσότερα »
CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease
Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease [CUTTING EDGE]: Leukocyte trafficking into the CNS is a prominent feature driving the immunopathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Blocking the recruitment of inflammatory leukocytes into the CNS represents an exploitable therapeutic target; however, the adhesion molecules that specifically regulate the step of leukocyte diapedesis into the CNS remain poorly understood. We report that CD99 is critical ... περισσότερα »
Autoimmune Encephalomyelitis : Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity
Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis [AUTOIMMUNITY]: The contribution of autoantibody-producing plasma cells in multiple sclerosis (MS) remains unclear. Anti-CD20 B cell depletion effectively reduces disease activity in MS patients, but it has a minimal effect on circulating autoantibodies and oligoclonal bands in the cerebrospinal fluid. Recently we reported that MEDI551, an anti-CD19 mAb, therapeutically ameliorates experimental autoimmune encephalomyelitis (EAE), the mouse model of MS. MEDI551 potently i... περισσότερα »
IFN-{alpha} Production by Human Plasmacytoid Dendritic Cells
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-{alpha} Production by Human Plasmacytoid Dendritic Cells [CLINICAL AND HUMAN IMMUNOLOGY]: Plasmacytoid dendritic cells (pDCs) produce large amounts of type I IFN in response to TLR7/9 ligands. This conveys antiviral effects, activates other immune cells (NK cells, conventional DCs, B, and T cells), and causes the induction and expansion of a strong inflammatory response. pDCs are key players in various type I IFN–driven autoimmune diseases such as systemic lupus erythematosus or psoriasis, but pDCs are also involved in ...περισσότερα »
CD16+ Monocytes in Immune Surveillance of the Central Nervous System
Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System [CLINICAL AND HUMAN IMMUNOLOGY]: Monocytes represent a heterogeneous population of primary immune effector cells. At least three different subsets can be distinguished based on expression of the low-affinity FcRIII: CD14++CD16*–* classical monocytes, CD14++CD16+ intermediate monocytes, and CD14+CD16*++* non-classical monocytes. Whereas CD16*–* classical monocytes are considered key players in multiple sclerosis (MS), little is known on CD16+ monocytes and how they contribute to the disease. In thi... περισσότερα »
Management of Primary Malignant Lymphoma of the Parotid Gland in a series of 745 patients
1.From 1980 to 2014, 745 consecutive patients were undergoing parotid surgery in our institution and 90 (12%) were diagnosed with a malignant tumour, with primary lymphoma of the parotid gland being diagnosed in 19 patients (21.1% of all malignant tumours and 2.6% of all parotidectomies). 2.Follicular lymphoma (n=9) was the most common histological type, followed by marginal cell lymphoma (n=7). The majority of cases were low grade lymphoma. 3.There are no distinguishing clinical or radiological features to help identify these cases as primary lymphoma before surgery. There was n...περισσότερα »
Editorial Board
Publication date: February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL via xlomafota13 on Inoreader http://ift.tt/1TWByMD via IFTTT
The Neonatal CD8+ T Cell Repertoire Rapidly Diversifies during Persistent Viral Infection
[IMMUNE REGULATION]: CMV is the most common congenital infection in the United States. The major target of congenital CMV is the brain, with clinical manifestations including mental retardation, vision impairment, and sensorineural hearing loss. Previous reports have shown that CD8+ T cells are required to control viral replication and significant numbers of CMV-specific CD8+ T cells persist in the brain even after the initial infection has been cleared. However, the dynamics of CD8+ T cells in the brain during latency remain largely undefined. In this report, we used TCR sequencin... περισσότερα »
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells
via C-Type Lectins and Inhibition of NF-{kappa}B [IMMUNE REGULATION]: Arabinogalactan (AG) isolated from dust of a traditional farm prevents disease in murine models of allergy. However, it is unclear whether this polysaccharide has immune regulatory properties in humans. The aim of this study was to test the influence of AG on the immune-stimulating properties of human dendritic cells (DCs). Moreover, we sought to identify the receptor to which AG binds. AG was produced from plant callus tissue under sterile conditions to avoid the influence of pathogen-associated molecular patte... περισσότερα »
Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection
Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection [INFECTIOUS DISEASE AND HOST RESPONSE]: The antimicrobial peptide cathelicidin is critical for protection against different kinds of microbial infection. This study sought to elucidate the protective action of cathelicidin against *Helicobacter pylori* infection and its associated gastritis. Exogenous cathelicidin was found to inhibit *H. pylori* growth, destroy the bacteria biofilm, and induce morphological alterations in *H. pylori* membrane. Additionally, knockdown of e... περισσότερα »
Kras Is Critical for B Cell Lymphopoiesis
[IMMUNE SYSTEM DEVELOPMENT]: The three major Ras members, Kras, Hras, and Nras, are highly homologous and individual Ras genes can have distinct biological functions. Embryonic lethality of Kras-deficient mice precludes study of the biological functions of this Ras family member. In this study, we generated and examined mice with hematopoietic-specific deletion of Kras and bone marrow (BM) chimeric mice with B cell–specific targeted deletion of Kras. Hematopoietic-specific deletion of Kras impaired early B cell development at the pre–B cell stage and late B cell maturation, resulti... περισσότερα »
CD57 in human natural killer cells and T-lymphocytes
CD57 in human natural killer cells and T-lymphocytes: AbstractThe CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to prolifera... περισσότερα »
The challenge of measuring IL-33 in serum using commercial ELISA: Lessons from asthma
The challenge of measuring IL-33 in serum using commercial ELISA: Lessons from asthma: Abstract Background Interleukin-33 (IL-33) has been subject of extensive study in the context of inflammatory disorders, particularly in asthma. Many human biological samples, including serum, have been used to determine the protein levels of IL-33, aiming to investigate its involvement in asthma. Reliable methods are required to study the association of IL-33 with disease, especially considering the complex nature of serum samples. Objective We evaluated four IL-33 ELISA kits, aiming to determine... περισσότερα »
Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice
Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background Accumulation of activated eosinophils in tissue is a hallmark of allergic inflammation. The endocannabinoid 2-arachidonoylglycerol (2-AG) has been proposed to elicit eosinophil migration in a CB2 receptor/Gi/o-dependent manner. However, it has been claimed recently that this process may also involve other mechanisms such as cytokine priming and the metabolism of 2-AG into eicosanoids. Here ... περισσότερα »
Honeybee venom allergy: Gas-filled microbubble-associated phospholipase A2
Efficacy of a therapeutic treatment using gas-filled microbubble-associated phospholipase A2 in a mouse model of honeybee venom allergy: Abstract Background Venom immunotherapy is efficient to desensitize people suffering from insect sting allergies. However, the numerous injections required over several years and important risks of severe side reactions complicate the wide-spread use of immunotherapy. In the search for novel approaches to blunt the overwhelming pro-allergic Th2 response, we evaluated the therapeutic efficacy of a treatment based on a denatured form of the major al... περισσότερα »
Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects
Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects: Background Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susceptibility variants associated with AR in the Chinese population. Methods A cohort of 402 individuals with physician-diagnosed AR and 416 healthy co... περισσότερα »
The baseline SNOT-22 in predicting outcomes for medical management of chronic rhinosinusitis
Patient-centered decision making: the role of the baseline SNOT-22 in predicting outcomes for medical management of chronic rhinosinusitis: Background For patients with chronic rhinosinusitis (CRS), the decision to elect continued medical management vs surgery is complex and involves tradeoffs between benefits, risks, and overall effectiveness of each therapy. The purpose of this study is to investigate whether baseline disease-specific quality of life (QOL) can assist in predicting outcomes in patients with refractory CRS who elect continued medical management. Methods CRS patients... περισσότερα »
Evaluation of nasal mucociliary transport rate according to nasal septum deviation type
Evaluation of nasal mucociliary transport rate according to nasal septum deviation type: Background Nasal septum deviation (NSD) may affect mucociliary activity (MCA) to varying degrees, depending upon the severity of the deviation. We used rhinoscintigraphy to determine the impact of the various NSD types on MCA. Methods A recent classification describing 6 different forms of NSD was used to standardize the study. Forty-eight subjects were enrolled. Eight patients for each form of NSD were accrued for further study. Rhinoscintigraphy was performed using technetium 99m macroaggregat... περισσότερα »
Early-life respiratory infections and asthma development
: role in disease pathogenesis and potential targets for disease prevention.: Purpose of review: This article presents recent findings and perspectives on the relationship between early-life respiratory infections and asthma inception, and discusses emerging concepts on strategies that target these infectious agents for asthma prevention. Recent findings: Cumulative evidence supports the role of early-life viral infections, especially respiratory syncytial virus and human rhinovirus, as major antecedents of childhood asthma. These viruses may have different mechanistic roles in the p... περισσότερα »
Autoimmune and Lymphoproliferative Complications of Common Variable Immunodeficiency
Autoimmune and Lymphoproliferative Complications of Common Variable Immunodeficiency: AbstractCommon variable immunodeficiency (CVID) is frequently complicated by the development of autoimmune and lymphoproliferative diseases. With widespread use of immunoglobulin replacement therapy, autoimmune and lymphoproliferative complications have replaced infection as the major cause of morbidity and mortality in CVID patients. Certain CVID complications, such as bronchiectasis, are likely to be the result of immunodeficiency and are associated with infection susceptibility. However, other... περισσότερα »
Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management
Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management: AbstractCorticosteroids are anti-inflammatory medications used widely to treat allergic inflammation. Although the endocrine and gastrointestinal side effects of corticosteroids have been described, the occurrence of immediate hypersensitivity reactions and delayed contact dermatitis due to corticosteroids remains under-recognized. Hypersensitivity reactions can occur to a corticosteroid itself, or to the additives and vehicles in corticosteroid preparations. Skin testing and oral graded... περισσότερα »
Mast Cells and Anaphylaxis
Mast Cells and Anaphylaxis: AbstractFor half a century, it has been known that the mast cell is the cell responsible for the majority of anaphylactic events. Its mediators, taken as a whole, are capable of producing all of the clinical manifestations of these events. With the discovery of immunoglobulin E (IgE), it was originally felt that the vast majority of anaphylactic episodes were due to antigen coupling with two cell-bound IgE molecules. More recently it has been learned that many episodes are produced by direct activation of mast cells, not involving antigen binding to IgE,... περισσότερα »
Recent advances in environmental controls outside the home setting.
Recent advances in environmental controls outside the home setting.: Purpose of review: It has been well studied that aeroallergen, mold, and airborne pollutant exposure in the inner-city home environment is associated with significant childhood asthma morbidity. Although the home environment has been extensively studied, the school environment is less well understood. Recent findings: In this article, we discuss the relationship between environmental exposures within the school and daycare environment and pediatric asthma morbidity and novel environmental interventions designed to h...περισσότερα »
Differences in hospital attendance for anaphylaxis between immigrants and non-immigrants: a cohort study
Differences in hospital attendance for anaphylaxis between immigrants and non-immigrants: a cohort study: Abstract Background The impact of migration on the risk of anaphylaxis is unknown. We hypothesized that non-Western immigrants have a lower incidence of anaphylaxis compared to Danish-born. We investigated variations in hospital attendance for anaphylaxis between immigrants and Danish-born including time- and age- trends. Methods A register-based, historical prospective cohort design. Refugees or family reunified immigrants (n=127,250) who, between January 1,1994 and December 3... περισσότερα »
Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs.
Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs.: Purpose of review: Human eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cell's granular uptake of eosin. Although eosinophils represent approximately 1% of peripheral blood leukocytes, they have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophils and their mediators are critical effectors to asthma and eosinophilic granulomatosis with polyangiitis (EGPA). Eosinophils are equipped with a large ... περισσότερα »
Timing of allergen exposure and the development of food allergy: treating before the horse is out of the barn.
Timing of allergen exposure and the development of food allergy: treating before the horse is out of the barn.: Purpose of review: Until recently, nutritional guidelines did not support early introduction of allergenic foods into the diet of high-risk infants. Following recent studies, this approach is beginning to change, at least for peanuts. This review will examine the change in nutritional guidelines and the scientific data that led to these changes. Recent finding: In a recent prospective controlled study, regular consumption of peanut protein in infants from 4-11 months of age... περισσότερα »
A randomized, 5-arm dose finding study with a mite allergoϊd SCIT in allergic rhinoconjunctivitis patients
A randomized, 5-arm dose finding study with a mite allergoϊd SCIT in allergic rhinoconjunctivitis patients: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background The safety and tolerability of a mite allergoϊd subcutaneous allergen immunotherapy (SCIT) product was previously established. The aim of this study was to find the optimally safe and effective allergoϊd dose by evaluating several dosages in patients with house dust mites (HDM)-induced allergic rhinoconjunctivitis (ARC) using a titrated nasal provocation test (TNPT). Methods In total, 290 adult ARC patie... περισσότερα »
IL-33 Mediates reactive eosinophilopoiesis in response to airborne allergen exposure
IL-33 Mediates reactive eosinophilopoiesis in response to airborne allergen exposure: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background Exposure to aeroallergens induces eosinophilic airway inflammation in patients with asthma and allergic airway diseases. The circulating number of eosinophils in peripheral blood is relatively small, leading us to hypothesize that bone marrow needs to be engaged quickly to meet the demands of the tissues. Methods To investigate the communication between the lungs and bone marrow, we used acute allergen exposure and airway inf... περισσότερα »
Transfer of peanut allergy through peripheral blood stem cell transplantation
A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation: Background: There exist several reports of atopy and allergen-specific IgE-mediated hypersensitivity transferred by bone marrow transplantation, and it has been concluded that the transfer of allergic reactivity results from adoptive transfer of IgE-producing donor-derived B- and/or plasma cells. To the best of our knowledge we report the first case of peanut allergy after PBSCT.Case PresentationA 55-year-old anciently non allergic man with secondary acute myeloid leukemia (AML) received ...περισσότερα »
Targeting FcγRs to treat antibody-dependent autoimmunity
Targeting FcγRs to treat antibody-dependent autoimmunity via Autoimmunity Reviews Publication date: Available online 6 February 2016 *Source:*Autoimmunity Reviews Author(s): Xiaojie Yu, Alan H. Lazarus Self-reactive antibodies represent a significant force in autoimmune disease induction. In antibody-dependent autoimmune syndromes such as immune thrombocytopenia (ITP), systemic lupus erythematosus (SLE), myasthenia gravis and rheumatoid arthritis (RA), autoantibodies exert their inflammatory effect through FcγRs, a well-established class of cell surface receptors that interact with the... περισσότερα »
Relapsing Polychondritis (RP)
Relapsing polychondritis: A clinical update via Autoimmunity Reviews Publication date: Available online 11 February 2016 *Source:*Autoimmunity Reviews Author(s): Lucia Longo, Antonio Greco, Andrea Rea, Vincenza Rita Lo Vasco, Armando De Virgilio, Marco De Vincentiis Relapsing polychondritis (RP) is a rare connective tissue disease in which recurrent bouts of inflammation, involve the cartilage of the ears, nose, larynx, tracheobronchial tree and cardiovascular system. RP is generally observed in the fourth and fifth decade of life and occur with equal frequency in both sexes. The cause...περισσότερα »
Role of the persistence of respiratory tract virus in immune disorders
New insight into the pathogenesis of minimal change nephrotic syndrome: Role of the persistence of respiratory tract virus in immune disorders via Autoimmunity Reviews Publication date: Available online 11 February 2016 *Source:*Autoimmunity Reviews Author(s): Hui Zhang, Zheng Wang, Liqun Dong, Yannan Guo, Jin Wu, Songhui Zhai The pathogenesis of minimal change nephrotic syndrome (MCNS) is a complex clinical problem which, unfortunately, has been in need of significant breakthroughs during decades. Improved understanding of the mechanisms is important to develop effective treatment str...περισσότερα »
Editorial Board
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TcDkby via IFTTT
Table of Contents
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1V8xgjG via IFTTT
Predictors of adherence to a 12-week exercise program among men treated for prostate cancer: ENGAGE study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Abstract Understanding the factors that influence adherence to exercise programs is necessary to develop effective interventions for people with cancer. We examined the predictors of adherence to a supervised exercise program for participants in the ENGAGE study – a cluster randomized controlled trial that assessed the efficacy of a clinician-referred 12-week exercise program among men […]
Liminality in Pediatric Palliative Care.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Authors: Carter BS Abstract Palliative care for infants, children, and adolescents encompasses numerous transitions and thresholds of uncertainty that challenge conventional clinical medicine. Palliative care clinicians have opportunities to be more comfortable amid such challenges, or perhaps even overcome them, if they are attuned to the unique times and places in which patients, their families, […]
Reiki Therapy for Symptom Management in Children Receiving Palliative Care: A Pilot Study.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
DISCUSSION: Decreased mean scores for outcome measures indicate that Reiki therapy did decrease pain, anxiety, heart, and respiratory rates, but small sample size deterred statistical significance. This preliminary work suggests that complementary methods of treatment such as Reiki may be beneficial to support traditional methods to manage pain and anxiety in children receiving palliative care. […]
Spirituality and Awareness of Diagnoses in Terminally Ill Patients With Cancer.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
CONCLUSION: In terminally ill patients with cancer, the levels of depression and anxiety were lower in patients aware of their own illness state. Moreover, higher levels of extrinsic and lower levels of intrinsic spirituality predicted the awareness of one’s own illness state. PMID: 26858171 [PubMed – as supplied by publisher] (Source: The American Journal of […]
Management of Primary Malignant Lymphoma of the Parotid Gland in a series of 745 patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
1.From 1980 to 2014, 745 consecutive patients were undergoing parotid surgery in our institution and 90 (12%) were diagnosed with a malignant tumour, with primary lymphoma of the parotid gland being diagnosed in 19 patients (21.1% of all malignant tumours and 2.6% of all parotidectomies). 2.Follicular lymphoma (n=9) was the most common histological type, followed […]
Atypical presentations of thrombotic thrombocytopenic purpura: a diagnostic role for ADAMTS13
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Abstract Thrombotic thrombocytopenic purpura (TTP) is an acute, life threatening disease. Only a minority of patients expresses the complete clinical presentation and unusual manifestations can occur. Demonstration of low activity levels of ADAMTS13 (<5 %) is highly specific for the diagnosis of TTP. This study reports a series of five cases of TTP presenting with […]
By targeting neurons in the hippocampus it is possible to inhibit or resurface a memory in mice
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Memory, i.e. our ability to record, to preserve and to recall our past experiences, makes up one of the most fundamental and fascinating abilities of our brain. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XnwnFc via IFTTT
Predictors of adherence to a 12-week exercise program among men treated for prostate cancer: ENGAGE study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Abstract Understanding the factors that influence adherence to exercise programs is necessary to develop effective interventions for people with cancer. We examined the predictors of adherence to a supervised exercise program for participants in the ENGAGE study – a cluster randomized controlled trial that assessed the efficacy of a clinician-referred 12-week exercise program among men […]
Cannabinoids and autoimmune diseases
: A systematic review via Autoimmunity Reviews Publication date: Available online 11 February 2016 *Source:*Autoimmunity Reviews Author(s): Valeria Katchan, Paula David, Yehuda Shoenfeld Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2 receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine release. Current research in the role of cannabinoids in the immune system shows that they possess immunosuppressive properties. They can inhibit proliferation of leucocytes, induce apoptosis of T cells and macrophages and redu... περισσότερα »
Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP).
Biotherapies in large vessels vasculitis via Autoimmunity Reviews Publication date: Available online 12 February 2016 *Source:*Autoimmunity Reviews Author(s): Y. Ferfar, T. Mirault, A.C. Desbois, C. Comarmond, E. Messas, L. Savey, F. Domont, P. Cacoub, D. Saadoun Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP). Glucorticosteroids are the mainstay of therapy in LVV. However, a significant proportion of patients have glucocorticoids dependance, seri...περισσότερα »
Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection
Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1O6mJ2B Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Defining swallowing-related quality of life profiles in individuals with amyotrophic lateral sclerosis
Dysphagia from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn20m Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Understanding autoimmunity: The ion channel perspective
Understanding autoimmunity: The ion channel perspective via Autoimmunity Reviews Publication date: Available online 12 February 2016 *Source:*Autoimmunity Reviews Author(s): Anantha Maharasi RamaKrishnan, Kavitha Sankaranarayanan Ion channels are integral membrane proteins that orchestrate the passage of ions across the cell membrane and thus regulate the various key physiological processes of the living system. The stringently regulated expression and function of these channels hold a pivotal role in the development and execution of various cellular functions. Malfunction of these cha...περισσότερα »
Association of KCNQ1 polymorphisms with gliclazide efficacy in Chinese type 2 diabetic patients.
Objectives: To investigate the effects of KCNQ1 polymorphisms on the efficacy of gliclazide in type 2 diabetic patients. Materials and methods: A total of 443 newly diagnosed type 2 diabetic patients were included in this study. After enrollment, patients went on an 8-week gliclazide monotherapy. Fasting plasma glucose (FPG) was measured before and after the treatment. Life-style information was collected by weekly follow-up. Genotyping of the two single-nucleotide polymorphisms was performed using the single base primer extension method. T-test, one-way analysis of variance, and Pe... περισσότερα »
Contents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TWBzQu via IFTTT
Your journal at the outset of 2016: A progress report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 Author(s): C. Martin, D. Chevalier, O. Laccourreye from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LkHUhw via IFTTT
Virtual planning and guided surgery in fibular free-flap mandibular reconstruction: A 29-case series
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Publication date: Available online 11 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D. Culié, O. Dassonville, G. Poissonnet, J.-C. Riss, J. Fernandez, A. Bozec IntroductionVirtual planning and guided surgery (VPGS) has been recently developed for mandibular reconstruction, but benefit remains to be assessed. The aim of this study was to analyze […]
Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as an important feature during tumor suppression mechanisms and a contributor to aging. Senescent cells have an altered secretion pattern called Senescence-Associated Secretory Phenotype (SASP) that comprises a complex mix of factors including cytokines, growth factors, chemokines, and […]
Positivity: The Dispositional Basis of Happiness
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract The present study examined in a stringent developmental model whether positivity, conceptualized as a pervasive mode of appraising, viewing, and perceiving life from a positive stance, predicts chronic positive affectivity across time or vice versa. Participants [263 participants (47 % males)], aged 15.5 at the beginning of the study and 23.5 at the end, reported […]
Hope and the Academic Trajectory of College Students
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Previous longitudinal studies of student hope have established a connection between how people think about the future and their college achievement. This study examined the role of hope in predicting the achievement and retention of college students while controlling for educational history and two other psychological constructs, academic self-efficacy and engagement. Hope, self-efficacy, engagement […]
Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
We recently demonstrated that brain-derived neurotrophic factor (BDNF) promotes periodontal tissue regeneration. The purpose of this study was to establish an essential component of a rational approach for the clinical application of BDNF in periodontal regenerative therapy. Here, we assessed the sequence of early events in BDNF-induced periodontal tissue regeneration, especially from the aspect of […]
Optoelectronic plethysmography to evaluate the effect of posture on breathing kinematics in spinal cord injury: A cross sectional study
European Journal of Physical and Rehabilitation Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o5Ojb4 via IFTTT
Prescriptions of antidepressants and anxiolytics in survivors of out-of-hospital cardiac arrest - a nationwide register-based follow-up study
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o5OkMk via IFTTT
The CG balloon is an innovative condom balloon tamponade for the management of postpartum hemorrhage in low-resource settings
International Journal of Gynecology & Obstetrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PQVdvI via IFTTT
Preinjury physical frailty and cognitive impairment among geriatric trauma patients determine postinjury functional recovery and survival
The Journal of Trauma and Acute Care Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o5P9oq via IFTTT
Human factors approach to comparative usability of hospital manual defibrillators
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PQVE99 via IFTTT
Use of out-of-hospital ethanol administration to improve outcome in mass methanol outbreaks
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o5P97P via IFTTT
Injury patterns and the role of tendons in protecting neurovascular structures in wrist injuries - Wrist soft tissue injury
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PQVGxP via IFTTT
The role of time-limited trials in dialysis decision making in critically ill patients
Clinical Journal of the American Society of Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o5P97J via IFTTT
Towards interventional trials on the use of oxygen during and after cardiac arrest
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBYsJ via IFTTT
Emergency department prescription opioids as an initial exposure preceding addiction
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QvWIMb via IFTTT
Transforming a team of experts into an expert team
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBXVG via IFTTT
Design and implementation of the resuscitation outcomes consortium Pragmatic Airway Resuscitation Trial (PART)
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBXVA via IFTTT
Effects of home-based tai chi and lower extremity training and self-practice on falls and functional outcomes in older fallers from the emergency department—a randomized controlled trial
Journal of the American Geriatrics Society from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QvWHHU via IFTTT
Diagnostic impact of bone-subtraction CT angiography for patients with acute subarachnoid hemorrhage
American Journal of Neuroradiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QvWFQo via IFTTT
Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?
Abstract Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term morbidities such as perinatal brain injury and bronchopulmonary dysplasia being particularly devastating. While advances in perinatal medicine have improved our understanding of the pathogenesis, effective therapies to prevent and/or reduce the severity of these disorders are still lacking. The potential of mesenchymal stem/stromal cell (MSC) therapy has emerged during... περισσότερα »
Acknowledgment of Authors [Acknowledgments]
[image: ASCO-Logo-Name-160x52.png] from Cancer via ola Kala on Inoreader http://ift.tt/1RutHoP via IFTTT
Reducing the Time From Diagnosis to Treatment of Patients With Stage II/III Rectal Cancer at a Large Public Hospital [Quality in Action]
Curative-intent therapy for stage II/III rectal cancer is necessarily complex. Current guidelines by the National Comprehensive Cancer Network recommend preoperative concurrent chemoradiation followed by resection and additional adjuvant chemotherapy. We used standard quality improvement methodology to implement a cost-effective intervention that reduced the time from diagnosis to treatment of patients with stage II/III rectal cancer by approximately 30% in a large public hospital in Houston, Texas. Implementation of the program resulted in a reduction in time from pathologic diag...περισσότερα »
Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration
We recently demonstrated that brain-derived neurotrophic factor (BDNF) promotes periodontal tissue regeneration. The purpose of this study was to establish an essential component of a rational approach for the clinical application of BDNF in periodontal regenerative therapy. Here, we assessed the sequence of early events in BDNF-induced periodontal tissue regeneration, especially from the aspect of cementum regeneration. Brain-derived neurotrophic factor was applied into experimental periodontal defects in Beagle dogs. The localization of cells positive for neurotrophic tyrosine ... περισσότερα »
Design of a protocol for obtaining genomic DNA from saliva using mouthwash: Samples taken from patients with periodontal disease
Publication date: Available online 11 February 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Ángel Chávez Mendoza, Beatriz Buentello Volante, María Esther Ocharán Hernández, Claudia Camelia Calzada Mendoza, Arturo Flores Pliego, Héctor A. Baptista Gonzalez, Higinio Estrada Juárez BackgroundObtaining high quality genomic DNA safely and economically is vital for diverse studies of large populations aimed at evaluating the role of genetic factors in susceptibility to disease.AimThis study was to test a protocol for the extraction of high quality genomic DNA ...περισσότερα »
Biological roles of KGF, CTGF and TGF-β in Cyclosporine-A- and Phenytoin- Induced Gingival Overgrowth; A Comparative Experimental Animal Study
Publication date: Available online 11 February 2016 *Source:*Archives of Oral Biology Author(s): Nadia Saeed Al-hamilly, Lobna R.S. Radwan, Mohamed Abdul-rahman, Mohamed I. Mourad, Mohammed E. Grawish ObjectiveTo identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other.MethodsSixty adult male albino rats were selected and divided into 3 equal groups. Group I rats received ...περισσότερα »
Growth factors and beta-tricalcium phosphate in the treatment of periodontal intraosseous defects: a systematic review and meta-analysis of randomised controlled trials
Publication date: Available online 11 February 2016 *Source:*Archives of Oral Biology Author(s): Claudiu Cãlin, Ion Pãtrașcu ObjectiveTo evaluate the effectiveness at different points in time, of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) coated onto a beta-tricalcium phosphate (β-TCP) carrier compared to β-TCP alone, or to recombinant human growth/differentiation factor-5 (rhGDF-5) adsorbed onto a β-TCP scaffold in intraosseous periodontal defects.DesignA digital search for randomised controlled trials (RCTs) was conducted on MEDLINE/PubMed. The quality of repo... περισσότερα »
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography
[image: alertIcon.gif] Publication date: Available online 11 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): W.-L. Xiao, D.-Z. Zhang, X.-J. Chen, C. Yuan, L.-F. Xue Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were... περισσότερα »
Letter to the Editor: Toward a Multifactorial Model of Caries Formation
from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1KJFy0X via IFTTT
Response to Letter to the Editor: Toward a Multifactorial Model of Caries Formation
from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1PGJ6hl via IFTTT
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography
Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were divided randomly into two groups. One group underwent GBR using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwen...περισσότερα »
Bony contact area and displacement of the temporomandibular joint after high-oblique and bilateral sagittal split osteotomy: a computer-simulated comparison
The most common way to move the mandible during orthognathic surgery is by bilateral sagittal split osteotomy (BSSO). The high-oblique sagittal split osteotomy (HSSO) is an alternative, although its use is limited by potential complications, mainly to do with the position of the condyle and reduced contact with bone. The aim of this study was to find out the optimal intercondylar distance and area of contact with the surface of the bone for mandibular advancement and setback in BSSO and HSSO. Data from computed tomographic (CT) images from 40 patients were loaded into special plan...περισσότερα »
Exploring the biophysical evidence that mammalian two pore channels are NAADP-activated calcium-permeable channels
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Abstract Nicotinic acid adenine dinucleotide phosphate (NAADP) potently releases Ca2+ from acidic intracellular endo-lysosomal Ca2+-stores. It is widely accepted that two types of two pore channels, termed TPC1 and TPC2, are responsible for the NAADP-mediated Ca2+-release but the underlying mechanisms regulating their gating appear to be different. For example, although both TPC1 and TPC2 are activated by NAADP, TPC1 appears to be additionally regulated by cytosolic Ca2+. Ion conduction and permeability also differ markedly. TPC1 and TPC2 are permeable to a range of cations althoug...περισσότερα »
Evaluation of rapid tests for diagnosis of acute hepatitis E
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Journal of Clinical Virology from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn2xg via IFTTT
Repeated measurements of hepatitis B surface antigen identify carriers of inactive HBV during long-term follow-up
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1O6mJ2K via IFTTT
Performance of the new aptima HCV quant Dx assay in comparison to the COBAS TaqMan HCV2 assay for use with the high pure system in the detection and quantification of HCV RNA in plasma or serum
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Journal of Clinical Microbiology from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn2gO via IFTTT
Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1O6mJ2B via IFTTT
Defining swallowing-related quality of life profiles in individuals with amyotrophic lateral sclerosis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Dysphagia from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn20m via IFTTT
Thanks to reviewers
Publication date: February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL via xlomafota13 on Inoreader http://ift.tt/1LkHWpH via IFTTT
Contents
Publication date: February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL via xlomafota13 on Inoreader http://ift.tt/1TWBzQu via IFTTT
Your journal at the outset of 2016: A progress report
Publication date: February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 Author(s): C. Martin, D. Chevalier, O. Laccourreye from #ORL via xlomafota13 on Inoreader http://ift.tt/1LkHUhw via IFTTT
Virtual planning and guided surgery in fibular free-flap mandibular reconstruction: A 29-case series
Publication date: Available online 11 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D. Culié, O. Dassonville, G. Poissonnet, J.-C. Riss, J. Fernandez, A. Bozec IntroductionVirtual planning and guided surgery (VPGS) has been recently developed for mandibular reconstruction, but benefit remains to be assessed. The aim of this study was to analyze the impact of VPGS on operative time and postoperative course.Material and methodsAll patients who underwent fibula free-flap mandibular reconstruction between 2013 and 2014 in our institutio...περισσότερα »
Norovirus infections occur in B cell deficient patients
Incidence of norovirus infection was compared between paediatric SCID patients with (n=10) and without (n=8) B cells. 60% and 63% of B+ and B– patients developed norovirus infections, with a log higher viral titre in B+ patients. We conclude that norovirus replication in B lymphocytes is not essential for infection. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1RvNMer via IFTTT
Noroviruses and B Cells
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1PGGeAY via IFTTT
A Bayesian nonparametric approach for uncovering rat hippocampal population codes during spatial navigation
[image: S01650270.gif] Publication date: 1 April 2016 *Source:*Journal of Neuroscience Methods, Volume 263 Author(s): Scott W. Linderman, Matthew J. Johnson, Matthew A. Wilson, Zhe Chen BackgroundRodent hippocampal population codes represent important spatial information about the environment during navigation. Computational methods have been developed to uncover the neural representation of spatial topology embedded in rodent hippocampal ensemble spike activity.New methodWe extend our previous work and propose a novel Bayesian nonparametric approach to infer rat hippocampal populat... περισσότερα »
Bone Mineral Density, 25-OH Vitamin D and Inflammation in Patients with Psoriasis
Abstract Background/Purpose Low levels of vitamin D may play a role in the pathogenesis of psoriasis and is related to increased risk of osteoporosis. There are a few studies showing increased rate of osteoporosis in psoriasis patients, however, none of them investigated impact of vitamin D levels and gender status together. We aimed to evaluate relationship between vitamin D and osteoporosis in psoriasis patients with an emphasis on gender difference. Methods Forty-three psoriasis patients without arthritis and 41 healthy controls were enrolled. All patients were <50 years and w...περισσότερα »
A Pediatric Case of Sclerodermatous Graft-Versus-Host Disease Responsive to Ultraviolet A1 Phototherapy
Abstract Graft-versus-host disease (GVHD) is one of the major complications after hematopoietic stem cell transplantation and is responsible for post-therapeutic morbidity, mortality, and poor quality of life of recipients. Sclerodermatous graft-versus-host disease (sGVHD) is a rare variant of chronic GVHD characterized by deposition of collagen in the skin and other soft tissues and resulting in loss of range of motion and functional capabilities. Treatment of sGVHD is challenging and largely limited by systemic side effects. Ultraviolet A1 phototherapy has been reported to be ef... περισσότερα »
De Novo Mutation in ABCC9 Causes Hypertrichosis Acromegaloid Facial Features Disorder
Abstract A 13-year-old Egyptian girl with generalized hypertrichosis, gingival hyperplasia, coarse facial appearance, no cardiovascular or skeletal anomalies, keloid formation, and multiple labial frenula was referred to our clinic for counseling. Molecular analysis of the *ABCC9* gene showed a de novo missense mutation located in exon 27, which has been described previously with Cantu syndrome. An overlap between Cantu syndrome, acromegaloid facial syndrome, and hypertrichosis acromegaloid facial features disorder is apparent at the phenotypic and molecular levels. The patient re...περισσότερα »
Treatment of Moderate to Severe Pediatric Psoriasis: A Retrospective Case Series
Abstract Background Psoriasis has an estimated prevalence of 0.5% to 2.0% in children. There is a paucity of data regarding the management and safety of treatments currently available for children with moderate to severe psoriasis. The aim of this study was to evaluate the treatment response and safety of systemic therapies used to manage moderate to severe pediatric psoriasis in a single referral center. Despite a small sample size, it was hypothesized that multiple therapeutics used for adult psoriasis would have a similar side-effect profile and positive disease response when u...περισσότερα »
Unilateral prurigo pigmentosa: A report of two cases
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1KK9BFw via IFTTT
Table of Contents
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1o5HEhd via IFTTT
An overview of burning mouth syndrome for the dermatologist
Summary Burning mouth syndrome is characterized by an idiopathic burning pain affecting the oral mucosa, with no clinically apparent changes. It can present to a variety of health professionals including dermatologists. This article summarizes the important aspects of the condition, including theories of pathogenesis, diagnosis and management. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1QbEpSe via IFTTT
Vemurafenib-induced hyperkeratosis of the areola treated with topical adapelene
Summary We present a rare condition, hyperkeratosis of the areola, induced by vemurafenib. Only a few papers have described an association of BRAF inhibitors with hyperkeratosis of the areola and/or nipple. Vemurafenib is a selective BRAF inhibitor used in patients with unresectable or metastatic melanoma who are positive for the V600 mutation. This drug has been associated with numerous cutaneous side effects, both benign and malignant. We report a male patient with vemurafenib-induced hyperkeratosis of the areola managed successfully with a topical retinoid, and describe for the ...περισσότερα »
Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration
We recently demonstrated that brain-derived neurotrophic factor (BDNF) promotes periodontal tissue regeneration. The purpose of this study was to establish an essential component of a rational approach for the clinical application of BDNF in periodontal regenerative therapy. Here, we assessed the sequence of early events in BDNF-induced periodontal tissue regeneration, especially from the aspect of cementum regeneration. Brain-derived neurotrophic factor was applied into experimental periodontal defects in Beagle dogs. The localization of cells positive for neurotrophic tyrosine ... περισσότερα »
Effects of meditation practice on spontaneous eyeblink rate
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Abstract A rapidly growing body of research suggests that meditation can change brain and cognitive functioning. Yet little is known about the neurochemical mechanisms underlying meditation-related changes in cognition. Here, we investigated the effects of meditation on spontaneous eyeblink rates (sEBR), a noninvasive peripheral correlate of striatal dopamine activity. Previous studies have shown a relationship […]
Differential heart rate responses to social and monetary reinforcement in women with obesity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Abstract Obesity is often accompanied by weight stigmatization; subsequently, individuals with obesity frequently face social rejection. It has been shown that recurrent negative social experiences can alter the perception of social cues. However, the way individuals with obesity process social stimuli is not well understood. This study aims to investigate obesity-related alterations in social compared […]
Dental Calculus Arrest of Dental Caries
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
The post Dental Calculus Arrest of Dental Caries appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LkHWGj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Randomized trial of a physical activity intervention in women with metastatic breast cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND Exercise interventions improve fitness, functional capacity, and quality of life in patients with early-stage breast cancer, but to the authors’ knowledge there are few data regarding the feasibility or potential benefits of exercise in women with metastatic breast cancer. METHODS Individuals with metastatic breast cancer were randomized 1:1 to a 16-week moderate-intensity exercise intervention […]
Thanks to reviewers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LkHWpH via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Editorial Board
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TWByMD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Contents
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TWBzQu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Your journal at the outset of 2016: A progress report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Publication date: February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 133, Issue 1 Author(s): C. Martin, D. Chevalier, O. Laccourreye from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LkHUhw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Virtual planning and guided surgery in fibular free-flap mandibular reconstruction: A 29-case series
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Publication date: Available online 11 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D. Culié, O. Dassonville, G. Poissonnet, J.-C. Riss, J. Fernandez, A. Bozec IntroductionVirtual planning and guided surgery (VPGS) has been recently developed for mandibular reconstruction, but benefit remains to be assessed. The aim of this study was to analyze […]
New test could help select the best treatment for bowel cancer patients https://t.co/DLEGty2zEm
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
New test could help select the best treatment for bowel cancer patients https://t.co/DLEGty2zEm from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/698096114915012608 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Effects of meditation practice on spontaneous eyeblink rate
[image: cover.gif?v=1&s=90bad8657ffbfb77a1508001] Abstract A rapidly growing body of research suggests that meditation can change brain and cognitive functioning. Yet little is known about the neurochemical mechanisms underlying meditation-related changes in cognition. Here, we investigated the effects of meditation on spontaneous eyeblink rates (sEBR), a noninvasive peripheral correlate of striatal dopamine activity. Previous studies have shown a relationship between sEBR and cognitive functions such as mind wandering, cognitive flexibility, and attention–functions that are also...περισσότερα »
Differential heart rate responses to social and monetary reinforcement in women with obesity
[image: cover.gif?v=1&s=90bad8657ffbfb77a1508001] Abstract Obesity is often accompanied by weight stigmatization; subsequently, individuals with obesity frequently face social rejection. It has been shown that recurrent negative social experiences can alter the perception of social cues. However, the way individuals with obesity process social stimuli is not well understood. This study aims to investigate obesity-related alterations in social compared to nonsocial information processing. Women with obesity (*n* = 14) and without obesity (*n* = 14) participated in a social and a m... περισσότερα »
Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli
Abstract Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as an important feature during tumor suppression mechanisms and a contributor to aging. Senescent cells have an altered secretion pattern called Senescence-Associated Secretory Phenotype (SASP) that comprises a complex mix of factors including cytokines, growth factors, chemokines, and matrix metalloproteinases. SASP has been related with local inflammation that leads to cellular transformation and neurodegenerative diseases. Various pathways for senescenc...περισσότερα »
Perceived Stress, Coping, and Cortisol Reactivity in Daily Life: A Study of Adolescents during the First Year of College
[image: S03010511.gif] Publication date: Available online 11 February 2016 *Source:*Biological Psychology Author(s): Michael R. Sladek, Leah D. Doane, Linda J. Luecken, Nancy Eisenberg Adolescents change how they cope with stress across different situations, but also differ from one another in their general capacity to cope. The current study examined whether cortisol reactivity to perceived daily stress varies with both situational (within-person) and individual (between-person) differences in coping. First-year college students (N=63;Mage=18.85) provided 15 stress-coping diaries a...περισσότερα »
Maurizio Battino and Hojjat Adeli being named a Thomson Reuters Highly Cited Researcher
IOS Press congratulates Maurizio Battino, Editor-in-Chief of *Journal of Berry Research* and *Mediterranean Journal of Nutrition and Metabolism*, and Hojjat Adeli, founder and Editor-in-Chief of *Integrated Computer-Aided Engineering*, on being recognized as a 2015 Thomson Reuters Highly Cited Researcher. Thomson Reuters carefully analyzed citation data over an 11-year period using Thomson Reuters Web of ScienceTM and InCitesTM to identify some of the best and brightest scientific minds of our time. Maurizio Battino and Hojjat Adeli were selected due to the number of citations th...περισσότερα »
Research discovers neuroprotective protein in blood is biomarker of Alzheimer’s disease
A new discovery by Tel Aviv University, Technion (Rambam Medical Center), and Harvard University researchers takes the medical community a leap forward in the process of effectively screening and diagnosing Alzheimer's disease. The new study, published in the *Journal of Alzheimer's Disease*, proposes a new biomarker for cognitive aging and Alzheimer's disease: activity-dependent neuroprotective protein (ADNP), the levels of which can be easily monitored in routine blood tests. The study also found that ADNP levels tested in the blood correlate with higher IQ in healthy older adult...περισσότερα »
Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant
Publication date: Available online 12 February 2016 *Source:*Journal of Proteomics Author(s): Lina Zhang, Marita de Waard, Hester Verheijen, Sjef Boeren, Jos A. Hageman, Toon van Hooijdonk, Jacques Vervoort, Johannes B. van Goudoever, Kasper Hettinga To objective of this study was to better understand the biological functions of breast milk proteins in relation to the growth and development of infants over the first six months of life. Breast milk samples from four individual women collected at seven time points in the first six months after delivery were analyzed by filter aided sa... περισσότερα »
Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps)
Publication date: Available online 12 February 2016 *Source:*Journal of Proteomics Author(s): Line P. Lauridsen, Andreas H. Laustsen, Bruno Lomonte, José María Gutiérrez A toxicovenomic study was performed on the venom of the green mamba, Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor (16.3%) families. Several sub-subfamilies of the 3FTxs were identified, such as Orphan Grou...περισσότερα »
Melanoma can control development of metastasis - fact or myth?
Publication date: Available online 12 February 2016 *Source:*Medical Hypotheses Author(s): Leo Čabrijan, Tanja Batinac, Jasna Lipozenčić The malignant melanoma spreading process cannot explain occurrence of metastases several years following local surgical therapy of primary malignancy. But, this complex process of delayed metastases is still challenging and not completely understood. We hypothese that melanoma metastases occur early in disease, probably at the same time with the occurrence of the primary melanoma. We suggest that dissemination of metastatic "seed cells" occur at an...περισσότερα »
A new concentric double prosthesis for sutureless, magnetic-assisted aortic arch inclusion
Publication date: Available online 11 February 2016 *Source:*Medical Hypotheses Author(s): Marco Cirillo Acute dissection of the ascending aorta is a life-threatening condition in which the aortic wall develops one or more tears of the intima associated with intramural rupture of the media layer with subsequent formation of a two lumina vessel. The remaining outer layer is just the adventitia, with high risk of complete rupture. Vital organs may be under-perfused. Mortality rate in this acute event is about 50% if an emergent surgical procedure is not performed as soon as possible t... περισσότερα »
Promising Link Between Selenium and Peroxisome Proliferator Activated Receptor Gamma in the Treatment Protocols of Obesity as well as Depression
Publication date: Available online 12 February 2016 *Source:*Medical Hypotheses Author(s): M.M. Donma, O. Donma Considerable interest has been given to the significance of peroxisome proliferator activated receptors (PPARs) in macronutrient metabolism, however, there is not sufficient data concerning the interactions between PPARs and micronutrients. Investigations performed on PPARγ and one of the essential micronutrients selenium (Se) have shown that both parameters may lead to alterations in obesity-related or mood disorders. Therefore, it is plausible to consider PPARγ and Se to... περισσότερα »
Maurizio Battino and Hojjat Adeli being named a Thomson Reuters Highly Cited Researcher
IOS Press congratulates Maurizio Battino, Editor-in-Chief of *Journal of Berry Research* and *Mediterranean Journal of Nutrition and Metabolism*, and Hojjat Adeli, founder and Editor-in-Chief of *Integrated Computer-Aided Engineering*, on being recognized as a 2015 Thomson Reuters Highly Cited Researcher. Thomson Reuters carefully analyzed citation data over an 11-year period using Thomson Reuters Web of ScienceTM and InCitesTM to identify some of the best and brightest scientific minds of our time. Maurizio Battino and Hojjat Adeli were selected due to the number of citations th...περισσότερα »
Research discovers neuroprotective protein in blood is biomarker of Alzheimer’s disease
A new discovery by Tel Aviv University, Technion (Rambam Medical Center), and Harvard University researchers takes the medical community a leap forward in the process of effectively screening and diagnosing Alzheimer's disease. The new study, published in the *Journal of Alzheimer's Disease*, proposes a new biomarker for cognitive aging and Alzheimer's disease: activity-dependent neuroprotective protein (ADNP), the levels of which can be easily monitored in routine blood tests. The study also found that ADNP levels tested in the blood correlate with higher IQ in healthy older adult...περισσότερα »
Role of reactive oxygen species in age-related neuromuscular deficits
Abstract Although it is now clear that reactive oxygen species (ROS) are not the key determinants of longevity, a number of studies have highlighted the key role that these species play in age-related diseases and more generally in determining individual health span. Age-related loss of skeletal muscle mass and function is a key contributor to physical frailty in older individuals and our current understanding of the key areas in which ROS contribute to age-related deficits in muscle is through defective redox signalling and key roles in maintenance of neuromuscular integrity. Thi... περισσότερα »
Exploring the biophysical evidence that mammalian two pore channels are NAADP-activated calcium-permeable channels
Abstract Nicotinic acid adenine dinucleotide phosphate (NAADP) potently releases Ca2+ from acidic intracellular endo-lysosomal Ca2+-stores. It is widely accepted that two types of two pore channels, termed TPC1 and TPC2, are responsible for the NAADP-mediated Ca2+-release but the underlying mechanisms regulating their gating appear to be different. For example, although both TPC1 and TPC2 are activated by NAADP, TPC1 appears to be additionally regulated by cytosolic Ca2+. Ion conduction and permeability also differ markedly. TPC1 and TPC2 are permeable to a range of cations althoug...περισσότερα »
Evaluation of rapid tests for diagnosis of acute hepatitis E
Journal of Clinical Virology from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn2xg via IFTTT
Repeated measurements of hepatitis B surface antigen identify carriers of inactive HBV during long-term follow-up
Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1O6mJ2K via IFTTT
Performance of the new aptima HCV quant Dx assay in comparison to the COBAS TaqMan HCV2 assay for use with the high pure system in the detection and quantification of HCV RNA in plasma or serum
Journal of Clinical Microbiology from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn2gO via IFTTT
Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection
Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1O6mJ2B via IFTTT
Defining swallowing-related quality of life profiles in individuals with amyotrophic lateral sclerosis
Dysphagia from #Medicine via ola Kala on Inoreader http://ift.tt/1Kfn20m via IFTTT
Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3
Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3 via Allergology International Publication date: Available online 10 February 2016 *Source:*Allergology International Author(s): Hidekazu Saito, Kohei Honda, Chikara Asaka, Shigeharu Ueki, Kazuo Ishikawa BackgroundThe chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved in eosinophil chemotaxis. It is thought that CCR3 plays an important role in the recruitment and activation of eosinophils in nasal polypo... περισσότερα »
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases: Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell typ... περισσότερα »
Allergen component analysis as a tool in the diagnosis of occupational allergy.
Allergen component analysis as a tool in the diagnosis of occupational allergy.: Purpose of review: Rapid developments have been seen in molecular allergy diagnosis, based on the detection and quantification of specific IgE to single allergens. This review summarizes and discusses studies on allergen component analysis as a tool in the diagnosis of occupational allergy. Recent findings: More than 400 agents are identified as sensitizers of occupational asthma, but only very few are characterized on the molecular level and available for routine diagnosis. Baker's asthma is one of the... περισσότερα »
Alu retroelements-associated autoimmunity in Sjögren's syndrome
Alu retroelements-associated autoimmunity in Sjögren's syndrome: Abstract A recent study by Hung T *et al*, (2015) published in Science 350(6259) pp455-59 provides an elegant set of experiments investigating the potential role of retroelements in the development of Systemic Lupus Erythematosus (SLE) (Hung et al, 2015). Findings of this study may provide a model linking the interaction of anti-Ro/SSA and Alu retroelements with fundamental mechanisms of autoimmunity in SLE and other related diseases including Sjögren's syndrome. This article is protected by copyright. All rights reser...περισσότερα »
Effects of low level laser therapy on the prognosis of split-thickness skin graft in type 3 burn of diabetic patients: a case series
Effects of low level laser therapy on the prognosis of split-thickness skin graft in type 3 burn of diabetic patients: a case series: AbstractSignificant populations in burn centers are diabetic burn patients. Healing process in these patients is more difficult due to diabetes complications. The gold standard treatment for patients with grade 3 burn ulcer is split-thickness skin grafting (STSG), but in the diabetic patients, the rate of graft failure and amputation is high due to impaired tissue perfusion. The technique of low level laser therapy (LLLT) improves tissue perfusion an... περισσότερα »
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting
: assessment by cone beam computed tomography via Oral and Maxillofacial Surgery Publication date: Available online 11 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): W.-L. Xiao, D.-Z. Zhang, X.-J. Chen, C. Yuan, L.-F. Xue Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was eva...περισσότερα »
Carbon dioxide laser ablation of dermatosis papulosa nigra
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin: AbstractDermatosis papulosa nigra (DPN) is a common condition of pigmented skin. Whilst lesions are benign, they may be symptomatic or cosmetically disfiguring. Ablative lasers have previously been reported as a useful therapeutic modality in DPN. We report the largest case series to date of patients with DPN ablated with the carbon dioxide (CO2) laser. A retrospective case note review was conducted of all patients with DPN treated in our laser clinic...περισσότερα »
Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats
Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats: AbstractThe aim of the present study was to evaluate the effects of photobiomodulation (PBM) on cytokine levels and angiogenesis during oral wound healing. Ulcers were made on the dorsum of the tongue in 48 Wistar rats. Irradiation with an indium-gallium-aluminum-phosphide (InGaAlP) laser (660 nm; output power, 40 mW; spot size, 0.04 cm2) was performed once a day on two points of the ulcer for 14 days. Two different energy densities were used: 4 J/cm2 (energy per point 0....περισσότερα »
KGF, CTGF and TGF-β in Cyclosporine-A- and Phenytoin- Induced Gingival Overgrowth
Biological roles of KGF, CTGF and TGF-β in Cyclosporine-A- and Phenytoin- Induced Gingival Overgrowth; A Comparative Experimental Animal Study via Oral Biology Publication date: Available online 11 February 2016 *Source:*Archives of Oral Biology Author(s): Nadia Saeed Al-hamilly, Lobna R.S. Radwan, Mohamed Abdul-rahman, Mohamed I. Mourad, Mohammed E. Grawish ObjectiveTo identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival ov...περισσότερα »
Obtaining genomic DNA from saliva using mouthwash
Design of a protocol for obtaining genomic DNA from saliva using mouthwash: Samples taken from patients with periodontal disease via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 11 February 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Ángel Chávez Mendoza, Beatriz Buentello Volante, María Esther Ocharán Hernández, Claudia Camelia Calzada Mendoza, Arturo Flores Pliego, Héctor A. Baptista Gonzalez, Higinio Estrada Juárez BackgroundObtaining high quality genomic DNA safely and economically is ...περισσότερα »
Fulminant zygomycosis of graft liver following liver transplantation
A 44-year-old man with hepatitis B virus (HBV)-related cirrhosis underwent living donor liver transplantation at our institute. Induction of immunosuppression was achieved with basiliximab, due to deranged renal function, and maintained with prednisolone, tacrolimus and mycophenolate mofetil. The intraoperative and immediate postoperative periods were fairly uneventful. A duplex scan, taken during the third week post-transplantation due to sudden rise in liver enzymes, revealed multifocal hypoechoic lesions in the graft liver with normal Doppler parameters. Multidetecor computed t... περισσότερα »
Inflammatory fibroid polyp (Vanek's tumour): my worst nightmare in the emergency department
A middle-aged woman presented in shock with bleeding per rectum for 2 days without any significant past medical or surgical illness. Abdominal sonography, oesophagogastroduodenoscopy and sigmoidocolonoscopy were unremarkable. Despite 6 units of blood transfusion, 3000 mL of plasma expanders and ionotropes, the arterial pressure gradually decreased. We had no choice but to undergo life-threatening yet possibly life saving laparotomy. We found a 1x1 cm ileal bleeding mucosal polyp about 20 cm away from the ileocaecal junction. We resected and anastomosed end to end. Perioperatively,... περισσότερα »
Sigmoid vaginoplasty in testicular feminising syndrome: surgical technique, outcome and review of the literature
Vaginal agenesis occurs in approximately 1:5000 live female births. It results from failure of the sinovaginal bulbs to develop and form the vaginal plate. Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the most common cause of vaginal absence followed by complete or partial androgen insensitivity syndrome. Treatment of these patients encompasses a spectrum from simple non-operative dilation to the more complicated surgical creation of a neovagina. We present a case of a patient with testicular feminising syndrome who was reared as a female and underwent bilateral gonadal excis...περισσότερα »
Dasatinib improves insulin sensitivity and affects lipid metabolism in a patient with chronic myeloid leukaemia
A 65-year-old woman had been visiting our department for the treatment of type-2 diabetes mellitus since December 2012. Her glycated haemoglobin levels were well controlled (5.8% (40 mmol/mol)) by metformin (500 mg). In July 2014, her white cell count increased suddenly to 33 530 cells/μL and she was diagnosed with Ph+ chronic myeloid leukaemia. She was started on dasatinib (100 mg), which immediately normalised plasma levels of WCC. Dasatinib improved the glycaemic index to <6.0% and also improved plasma levels of triglycerides (TGs) and high-density lipoprotein-cholesterol (HDL-...περισσότερα »
Ectopic pregnancy in an undescended fallopian tube: a diagnostic challenge
Uterine malformations are the most frequent anomalies of the Müllerian ducts, but undescended ovaries and fallopian tubes are very rare congenital defects. Pregnancy in these misplaced organs may occur, frequently posing a diagnostic challenge. A case of a ruptured ectopic pregnancy in an undescended fallopian tube associated with other genital malformations is presented. This case provides evidence for the recognised phenomenon of peritoneal gametes or embryo transmigration. from Cases via ola Kala on Inoreader http://ift.tt/1V8h4yW via IFTTT
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 11 February 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): W.-L. Xiao, D.-Z. Zhang, X.-J. Chen, C. Yuan, L.-F. Xue Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect […]
Prevalence of insomnia-related symptoms continues to increase in the Finnish working-age population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary In 2008, we published epidemiological data from 1972 to 2005 that suggested an increase in insomnia-related symptoms among the working-age population. The results were based on the National FINRISK (FR) Study samples of the Finnish adult population aged 25–64, and on the Finnish Quality of Work Life Surveys (FQWLS), carried out among Finnish salary […]
Objective but not subjective sleep predicts memory in community-dwelling older adults
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Research on the relationship between habitual sleep patterns and memory performance in older adults is limited. No previous study has used objective and subjective memory measures in a large, older-aged sample to examine the association between sleep and various domains of memory. The aim of this study was to examine the association between objective […]
Greater occipital nerve blockade for the treatment of chronic migraine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QbpnvJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KK34uy via IFTTT
Fulminant zygomycosis of graft liver following liver transplantation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A 44-year-old man with hepatitis B virus (HBV)-related cirrhosis underwent living donor liver transplantation at our institute. Induction of immunosuppression was achieved with basiliximab, due to deranged renal function, and maintained with prednisolone, tacrolimus and mycophenolate mofetil. The intraoperative and immediate postoperative periods were fairly uneventful. A duplex scan, taken during the third week post-transplantation […]
Inflammatory fibroid polyp (Vanek’s tumour): my worst nightmare in the emergency department
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A middle-aged woman presented in shock with bleeding per rectum for 2 days without any significant past medical or surgical illness. Abdominal sonography, oesophagogastroduodenoscopy and sigmoidocolonoscopy were unremarkable. Despite 6 units of blood transfusion, 3000 mL of plasma expanders and ionotropes, the arterial pressure gradually decreased. We had no choice but to undergo life-threatening yet […]
Sigmoid vaginoplasty in testicular feminising syndrome: surgical technique, outcome and review of the literature
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Vaginal agenesis occurs in approximately 1:5000 live female births. It results from failure of the sinovaginal bulbs to develop and form the vaginal plate. Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the most common cause of vaginal absence followed by complete or partial androgen insensitivity syndrome. Treatment of these patients encompasses a spectrum from simple non-operative dilation to […]
Dasatinib improves insulin sensitivity and affects lipid metabolism in a patient with chronic myeloid leukaemia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A 65-year-old woman had been visiting our department for the treatment of type-2 diabetes mellitus since December 2012. Her glycated haemoglobin levels were well controlled (5.8% (40 mmol/mol)) by metformin (500 mg). In July 2014, her white cell count increased suddenly to 33 530 cells/μL and she was diagnosed with Ph+ chronic myeloid leukaemia. She […]
A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
During the past few decades there has been a significantly increasing trend in germ cell tumours all over the world, particularly in countries with Caucasian populations. The changes in incidence have occurred so fast that only environmental factors can explain this development. This review focuses on the hypothesis that testicular germ cell cancer, which originates […]
Ectopic pregnancy in an undescended fallopian tube: a diagnostic challenge
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Uterine malformations are the most frequent anomalies of the Müllerian ducts, but undescended ovaries and fallopian tubes are very rare congenital defects. Pregnancy in these misplaced organs may occur, frequently posing a diagnostic challenge. A case of a ruptured ectopic pregnancy in an undescended fallopian tube associated with other genital malformations is presented. This case […]
The expression of TSSC3 and its prognostic value in patients with osteosarcoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:Biomedicine & Pharmacotherapy, Volume 79 Author(s): Xing Wang, Huisen He, Kai Zhang, Wanyou Peng Osteosarcoma is one of the most common primary bone tumors in children and adolescents, typically presenting with poor prognosis. Recent studies have found that TSSC3 had a potential capability in suppressing the tumor development in osteosarcoma. Our […]
Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice
Endocrinology, Early Release. from thyroid via a.lsfakia on Inoreader http://ift.tt/1LkriGF via IFTTT
Design of a protocol for obtaining genomic DNA from saliva using mouthwash: Samples taken from patients with periodontal disease
Publication date: Available online 11 February 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Ángel Chávez Mendoza, Beatriz Buentello Volante, María Esther Ocharán Hernández, Claudia Camelia Calzada Mendoza, Arturo Flores Pliego, Héctor A. Baptista Gonzalez, Higinio Estrada Juárez BackgroundObtaining high quality genomic DNA safely and economically is vital for diverse studies of large populations aimed at evaluating the role of genetic factors in susceptibility to disease.AimThis study was to test a protocol for the extraction of high quality genomic DNA ...περισσότερα »
Biological roles of KGF, CTGF and TGF-β in Cyclosporine-A- and Phenytoin- Induced Gingival Overgrowth; A Comparative Experimental Animal Study
Publication date: Available online 11 February 2016 *Source:*Archives of Oral Biology Author(s): Nadia Saeed Al-hamilly, Lobna R.S. Radwan, Mohamed Abdul-rahman, Mohamed I. Mourad, Mohammed E. Grawish ObjectiveTo identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other.MethodsSixty adult male albino rats were selected and divided into 3 equal groups. Group I rats received ...περισσότερα »
Growth factors and beta-tricalcium phosphate in the treatment of periodontal intraosseous defects: a systematic review and meta-analysis of randomised controlled trials
Publication date: Available online 11 February 2016 *Source:*Archives of Oral Biology Author(s): Claudiu Cãlin, Ion Pãtrașcu ObjectiveTo evaluate the effectiveness at different points in time, of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) coated onto a beta-tricalcium phosphate (β-TCP) carrier compared to β-TCP alone, or to recombinant human growth/differentiation factor-5 (rhGDF-5) adsorbed onto a β-TCP scaffold in intraosseous periodontal defects.DesignA digital search for randomised controlled trials (RCTs) was conducted on MEDLINE/PubMed. The quality of repo... περισσότερα »
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography
[image: alertIcon.gif] Publication date: Available online 11 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): W.-L. Xiao, D.-Z. Zhang, X.-J. Chen, C. Yuan, L.-F. Xue Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were... περισσότερα »
Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography
Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were divided randomly into two groups. One group underwent GBR using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwen...περισσότερα »
Bony contact area and displacement of the temporomandibular joint after high-oblique and bilateral sagittal split osteotomy: a computer-simulated comparison
The most common way to move the mandible during orthognathic surgery is by bilateral sagittal split osteotomy (BSSO). The high-oblique sagittal split osteotomy (HSSO) is an alternative, although its use is limited by potential complications, mainly to do with the position of the condyle and reduced contact with bone. The aim of this study was to find out the optimal intercondylar distance and area of contact with the surface of the bone for mandibular advancement and setback in BSSO and HSSO. Data from computed tomographic (CT) images from 40 patients were loaded into special plan...περισσότερα »
Excision Margins for Melanoma In Situ on the Head and Neck.
BACKGROUND: Complete surgical excision of melanoma in situ (MIS) is curative. A 5-mm margin is often taken as the standard primary excision margin despite increasing evidence that this is frequently inadequate for tumor clearance. OBJECTIVE: To calculate the proportion of patients requiring >5 mm margin for clearance and to investigate any patient/lesion characteristics necessitating larger margins. MATERIALS AND METHODS: Three hundred forty-three primary MIS cases on the head and neck treated in the authors' department by Mohs micrographic surgery (MMS) over a 65-month period were ... περισσότερα »
Conservative Treatment of Osteoradionecrosis of the Cranium After Treatment of Cutaneous Malignancy With Mohs Surgery and Postoperative Radiation.
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/240FTCM via IFTTT
Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice
Endocrinology, Early Release. from thyroid via a.lsfakia on Inoreader http://ift.tt/1LkriGF via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1o5SmUO via IFTTT
A new concentric double prosthesis for sutureless, magnetic-assisted aortic arch inclusion
Publication date: Available online 11 February 2016 Source:Medical Hypotheses Author(s): Marco Cirillo Acute dissection of the ascending aorta is a life-threatening condition in which the aortic wall develops one or more tears of the intima associated with intramural rupture of the media layer with subsequent formation of a two lumina vessel. The remaining outer layer… Continue reading A new concentric double prosthesis for sutureless, magnetic-assisted aortic arch inclusion
Promising Link Between Selenium and Peroxisome Proliferator Activated Receptor Gamma in the Treatment Protocols of Obesity as well as Depression
Publication date: Available online 12 February 2016 Source:Medical Hypotheses Author(s): M.M. Donma, O. Donma Considerable interest has been given to the significance of peroxisome proliferator activated receptors (PPARs) in macronutrient metabolism, however, there is not sufficient data concerning the interactions between PPARs and micronutrients. Investigations performed on PPARγ and one of the essential micronutrients selenium… Continue reading Promising Link Between Selenium and Peroxisome Proliferator Activated Receptor Gamma in the Treatment Protocols of Obesity as well as Dep... περισσότερα »
Prevalence of insomnia-related symptoms continues to increase in the Finnish working-age population
Summary In 2008, we published epidemiological data from 1972 to 2005 that suggested an increase in insomnia-related symptoms among the working-age population. The results were based on the National FINRISK (FR) Study samples of the Finnish adult population aged 25–64, and on the Finnish Quality of Work Life Surveys (FQWLS), carried out among Finnish salary… Continue reading Prevalence of insomnia-related symptoms continues to increase in the Finnish working-age population
Rai Scuola Memex, la scienza raccontata dai protagonisti: Villarini e Cascina Rosa sul cibo
Rai Scuola Memex, la scienza raccontata dai protagonisti: «Il cibo» In onda dal 15 al 19 febbraio 2016, dal lunedì al venerdì alle 21:00 (in replica alle 13:00 del giorno seguente) su Rai Scuola (canale 146 del digitale terrestre) e su Raidue il sabato e la domenica alle 6:30. Puntata del 16 febbraio 2016: «Cibo… Continue reading Rai Scuola Memex, la scienza raccontata dai protagonisti: Villarini e Cascina Rosa sul cibo
Making the natural switch from fight and flight – Vernon Morning Star
Making the natural switch from fight and flight Vernon Morning Star Our stress response, also known as “fight or flight,” is an ancient biochemical message that is a lifesaving mechanism controlled by our adrenal glands. When we are in an emergency situation … Stress is a driving factor in unhealthy weight gain (due … from… Continue reading Making the natural switch from fight and flight – Vernon Morning Star
Traumatic iridial extrusion mimicking a conjunctival melanocytic neoplasm
Pablo Zoroquiain, Maria SB Ganimi, Sarah Alghamdi, Julia V Burnier, Sultan S Aldrees and Miguel N Burnier from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1o5Equ9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O6qXaF via IFTTT
Editorial Board
Publication date: April 2016 Source:Cellular Signalling, Volume 28, Issue 4 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O6mwwh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O6qZiO via IFTTT
Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
Publication date: Available online 12 February 2016 Source:Cellular Signalling Author(s): Bryan B. Bridgeman, Pu Wang, Boping Ye, Jill C. Pelling, Olga V. Volpert, Xin Tong Ultraviolet B (UVB) radiation is the major environmental risk factor for developing skin cancer,the most common cancer worldwide, which is characterized byaberrant activation of Akt/mTOR (mammalian target of rapamycin). Importantly,… Continue reading Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
Limitations of N-Terminal Pro-B-Type Natriuretic Peptide in the Diagnosis of Heart Disease among Cancer Patients Who Present with Cardiac or Pulmonary Symptoms
Objectives: Recognizing heart disease is relevant to oncologists because cancer patients are at an increased risk of cardiac mortality due to shared risk factors and the adverse effects of cancer therapy. This study assessed the extent to which the measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) aids in the diagnosis of heart disease in addition… Continue reading Limitations of N-Terminal Pro-B-Type Natriuretic Peptide in the Diagnosis of Heart Disease among Cancer Patients Who Present with Cardiac or Pulmonary Symptoms
Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Authors: Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV Abstract Lung cancer is the leading cause of cancer death. Beyond first line treatment, few therapeutic options are available, particularly for squamous cell carcinoma (SCC). Here, we have explored the phospholipidomes of 30 human SCCs and found that they almost invariably (in 96.7% of cases) contain phospholipids with longer acyl c... περισσότερα »
Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Authors: Morishita M, Muramatsu T, Suto Y, Hirai M, Konishi T, Hayashi S, Shigemizu D, Tsunoda T, Moriyama K, Inazawa J Abstract Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of a series of subsequent and random alterations. Chromothripsis occurs commonly in various human cancers and is thought to be associated with increased malignancy and carcinogenesis. However, the causes and consequences of chromothripsis remain unclear. Therefore, to identify the mechanism underlying the ... περισσότερα »
Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Neuropilins are receptors for disparate ligands, including proangiogenic factors such as vascular endothelial growth factor and inhibitory class 3 semaphorin (SEMA3) family members. Differentiated cells in skin epithelium and cutaneous squamous cell carcinoma highly express the neuropilin-1 (NRP1) receptor. We examined the expression of NRP1 in human and mouse oral mucosa. NRP1 was significantly up-regulated in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). NRP1 receptor localized to the outer suprabasal epithelial layers in normal tongue, an expression pattern ...περισσότερα »
Fertility defects in Surfactant associated protein D knockout female mice: altered ovarian hormone profile
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Sharon Kay, Taruna Madan Surfactant associated protein D (SFTPD, also known as SP-D), a pattern recognition molecule, is an integral component of the mucosal immune system of female reproductive tract (FRT). In addition to host defense functions in the FRT, recent evidences indicate immunomodulatory role of SFTPD in parturition and pre-term labor. Regulation of SFTPD expression by ovarian hormones in the mouse uterus implicates SFTPD of FRT in pregnancy establishment and maintenance. In the current stud... περισσότερα »
Effect of Evodiamine on CYP Enzymes in Rats by a Cocktail Method
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of this study was to assess the influence of evodiamine on the activities of the drug-metabolizing enzymes cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in rats. The activities of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 were measured using specific probe drugs. After pretreatment for 1 week with evodiamine or physiological saline […]
Protective Effect of Naringenin against Lipopolysaccharide-Induced Acute Lung Injury in Rats
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background/Aims: Lipopolysaccharide (LPS) induces acute lung injury (ALI) through oxidative stress and inflammation. Naringenin exerts antioxidant and anti-inflammatory effects. The possible protective effect of naringenin was investigated against ALI induced by LPS in rats. Methods: Rats received a single injection of LPS (5 mg/kg, i.v.). Naringenin was given for 4 consecutive days, at 2 doses […]
«Much more than just another private collection»: the Schocken Library and its rescue from Nazi Germany in 1935
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mwoAYc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fulminant zygomycosis of graft liver following liver transplantation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A 44-year-old man with hepatitis B virus (HBV)-related cirrhosis underwent living donor liver transplantation at our institute. Induction of immunosuppression was achieved with basiliximab, due to deranged renal function, and maintained with prednisolone, tacrolimus and mycophenolate mofetil. The intraoperative and immediate postoperative periods were fairly uneventful. A duplex scan, taken during the third week post-transplantation […]
Inflammatory fibroid polyp (Vanek’s tumour): my worst nightmare in the emergency department
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A middle-aged woman presented in shock with bleeding per rectum for 2 days without any significant past medical or surgical illness. Abdominal sonography, oesophagogastroduodenoscopy and sigmoidocolonoscopy were unremarkable. Despite 6 units of blood transfusion, 3000 mL of plasma expanders and ionotropes, the arterial pressure gradually decreased. We had no choice but to undergo life-threatening yet […]
Sigmoid vaginoplasty in testicular feminising syndrome: surgical technique, outcome and review of the literature
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Vaginal agenesis occurs in approximately 1:5000 live female births. It results from failure of the sinovaginal bulbs to develop and form the vaginal plate. Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the most common cause of vaginal absence followed by complete or partial androgen insensitivity syndrome. Treatment of these patients encompasses a spectrum from simple non-operative dilation to […]
Dasatinib improves insulin sensitivity and affects lipid metabolism in a patient with chronic myeloid leukaemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A 65-year-old woman had been visiting our department for the treatment of type-2 diabetes mellitus since December 2012. Her glycated haemoglobin levels were well controlled (5.8% (40 mmol/mol)) by metformin (500 mg). In July 2014, her white cell count increased suddenly to 33 530 cells/μL and she was diagnosed with Ph+ chronic myeloid leukaemia. She […]
Ectopic pregnancy in an undescended fallopian tube: a diagnostic challenge
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Uterine malformations are the most frequent anomalies of the Müllerian ducts, but undescended ovaries and fallopian tubes are very rare congenital defects. Pregnancy in these misplaced organs may occur, frequently posing a diagnostic challenge. A case of a ruptured ectopic pregnancy in an undescended fallopian tube associated with other genital malformations is presented. This case […]
Design of a protocol for obtaining genomic DNA from saliva using mouthwash: Samples taken from patients with periodontal disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 11 February 2016 Source:Journal of Oral Biology and Craniofacial Research Author(s): Ángel Chávez Mendoza, Beatriz Buentello Volante, María Esther Ocharán Hernández, Claudia Camelia Calzada Mendoza, Arturo Flores Pliego, Héctor A. Baptista Gonzalez, Higinio Estrada Juárez BackgroundObtaining high quality genomic DNA safely and economically is vital for diverse studies of large populations […]
Was ist schön? Auch Zwillinge sind sich darüber nicht einig
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Attraktivität Menschen lieben symmetrische Gesichter. Doch darüber hinaus liegt Schönheit einer US-Studie zufolge auch im Auge des Betrachters. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TcrP4b via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Three dimensional multi-segmental trunk kinematics and kinetics during gait: Test-retest reliability and minimal detectable change
Publication date: Available online 11 February 2016 *Source:*Gait & Posture Author(s): Rita Fernandes, Paulo Armada-da-Silva, Annelies Pool-Goudaazward, Vera Moniz-Pereira, António P. Veloso Background and AimTrunk kinematics and kinetics can contribute to more detailed information on gait impairment, however data about reliability and measurement error of multi-segment trunk on three-dimensional gait analysis (3DGA) is lacking. The aim of this study is to investigate test-retest reliability and MDC of 3DGA kinematic and kinetic data in a sample of healthy individuals, using a two r...περισσότερα »
From Normal to Fast Walking: Impact of Cadence and Stride Length on Lower Extremity Joint Moments
Publication date: Available online 11 February 2016 *Source:*Gait & Posture Author(s): Marzieh M. Ardestani, Christopher Ferrigno, Mehran Moazen, Markus A. Wimmer This study aimed to clarify the influence of various speeding strategies (i.e. adjustments of cadence and stride length) on external joint moments. This study investigated the gait of 52 healthy subjects who performed self-selected normal and fast speed walking trials in a motion analysis laboratory. Subjects were classified into three separate groups based on how they increased their speed from normal to fast walking: (i)...περισσότερα »
Lower limb joint forces during walking on the level and slopes at different inclinations
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Nathalie Alexander, Hermann Schwameder Sloped walking is associated with an increase of lower extremity joint loading compared to level walking. Therefore, the aim of this study was to analyse lower limb joint compression forces as well as tibiofemoral joint shear forces during sloped walking at different inclinations. Eighteen healthy male participants (age: 27.0±4.7 years, height: 1.80±0.05m, mass: 74.5±8.2kg) were asked to walk at a pre-set speed of 1.1m/s on a ramp (6m×1.5m) at the slopes of −18°, −12°, −...περισσότερα »
Development of adaptive sensorimotor control in infant sitting posture
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Li-Chiou Chen, John Jeka, Jane E. Clark A reliable and adaptive relationship between action and perception is necessary for postural control. Our understanding of how this adaptive sensorimotor control develops during infancy is very limited. This study examines the dynamic visual–postural relationship during early development. Twenty healthy infants were divided into 4 developmental groups (each n=5): sitting onset, standing alone, walking onset, and 1-year post-walking. During the experiment, the infant sat... περισσότερα »
Three dimensional multi-segmental trunk kinematics and kinetics during gait: Test-retest reliability and minimal detectable change
Publication date: Available online 11 February 2016 *Source:*Gait & Posture Author(s): Rita Fernandes, Paulo Armada-da-Silva, Annelies Pool-Goudaazward, Vera Moniz-Pereira, António P. Veloso Background and AimTrunk kinematics and kinetics can contribute to more detailed information on gait impairment, however data about reliability and measurement error of multi-segment trunk on three-dimensional gait analysis (3DGA) is lacking. The aim of this study is to investigate test-retest reliability and MDC of 3DGA kinematic and kinetic data in a sample of healthy individuals, using a two r...περισσότερα »
Association of KCNQ1 polymorphisms with gliclazide efficacy in Chinese type 2 diabetic patients.
Objectives: To investigate the effects of KCNQ1 polymorphisms on the efficacy of gliclazide in type 2 diabetic patients. Materials and methods: A total of 443 newly diagnosed type 2 diabetic patients were included in this study. After enrollment, patients went on an 8-week gliclazide monotherapy. Fasting plasma glucose (FPG) was measured before and after the treatment. Life-style information was collected by weekly follow-up. Genotyping of the two single-nucleotide polymorphisms was performed using the single base primer extension method. T-test, one-way analysis of variance, and Pe... περισσότερα »
Estimating annual medical and out-of-pocket expenditures associated with traumatic injuries in the United States
The Journal of Trauma and Acute Care Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QvWHrr via IFTTT
An evaluation of emergency medicine core content covered by free open access medical education resources
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBUsX via IFTTT
Same physician, different location, different patient satisfaction scores
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QvWHb2 via IFTTT
Association of exhaled carbon monoxide with stroke incidence and subclinical vascular brain injury
Stroke from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBX89 via IFTTT
Evolving mechanisms of injury and management of pediatric blunt renal trauma - 20 years of experience
Urology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RvBWRA via IFTTT
Incidence, characteristics, and long-term follow-up of sternoclavicular injuries: An epidemiologic analysis of 92 cases
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A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
During the past few decades there has been a significantly increasing trend in germ cell tumours all over the world, particularly in countries with Caucasian populations. The changes in incidence have occurred so fast that only environmental factors can explain this development. This review focuses on the hypothesis that testicular germ cell cancer, which originates […]
Hormonal Eligibility Criteria for ‘Includes Females’ Competition: A Practical but Problematic Solution
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The International Association of Athletics Federations (IAAF) and the International Olympic Committee (IOC) adopted testosterone level criteria for eligibility (i.e. 10 nmol/l or 290 ng/dl in blood for IAAF, levels ‘within the male range’ for IOC) to compete in the ‘includes females’ category. The policies address the assertion that women with very high endogenous testosterone […]
Why smiles, frowns and grimaces are contagious
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Our ability to instantaneously read other people’s emotions is astounding. A recent paper explains why mimicking other’s facial expressions is such a vital part of being human. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1V8byw7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fertility defects in Surfactant associated protein D knockout female mice: altered ovarian hormone profile
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Sharon Kay, Taruna Madan Surfactant associated protein D (SFTPD, also known as SP-D), a pattern recognition molecule, is an integral component of the mucosal immune system of female reproductive tract (FRT). In addition to host defense functions in the FRT, recent evidences indicate immunomodulatory role of […]
A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Xiaoxiao Ren, Leyi Wang, Xinyi Wu Our previous studies reported that pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors (NLRs), recognize pathogen-associated molecular patterns (PAMPS) to initiate downstream signal cascades to active immunity responses. Thymic stromal lymphopoietin (TSLP) has […]
MicroRNA–21 as a novel biomarker in diagnosis and response to therapy in asthmatic children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Rabab M. Elbehidy, Doaa M. Youssef, Amal S. El-Shal, Sally M. Shalaby, Hanan S. Sherbiny, Laila M. Sherief, Nagwa E Akeel BackgroundThe underlying molecular mechanisms leading to asthma remain largely unclear. MicroRNAs (miRNAs) are short noncoding RNAs exert powerful effects on immunological function by tuning networks […]
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