Food allergy and omics

Publication date: January 2018
Source:Journal of Allergy and Clinical Immunology, Volume 141, Issue 1
Author(s): Gopal Krishna Dhondalay, Efren Rael, Swati Acharya, Wenming Zhang, Vanitha Sampath, Stephen J. Galli, Robert Tibshirani, Scott D. Boyd, Holden Maecker, Kari Christine Nadeau, Sandra Andorf
Food allergy (FA) prevalence has been increasing over the last few decades and is now a global health concern. Current diagnostic methods for FA result in a high number of false-positive results, and the standard of care is either allergen avoidance or use of epinephrine on accidental exposure, although currently with no other approved treatments. The increasing prevalence of FA, lack of robust biomarkers, and inadequate treatments warrants further research into the mechanism underlying food allergies. Recent technological advances have made it possible to move beyond traditional biological techniques to more sophisticated high-throughput approaches. These technologies have created the burgeoning field of omics sciences, which permit a more systematic investigation of biological problems. Omics sciences, such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, and exposomics, have enabled the construction of regulatory networks and biological pathway models. Parallel advances in bioinformatics and computational techniques have enabled the integration, analysis, and interpretation of these exponentially growing data sets and opens the possibility of personalized or precision medicine for FA.



http://ift.tt/2Ar907H