TOPICAL CHLORHEXIDINE, POVIDONE-IODINE AND ERYTHROMYCIN IN THE REPAIR OF TRAUMATIC ULCERS ON THE RAT TONGUE: CLINICAL, HISTOLOGICAL AND MICROBIOLOGICAL EVALUATION

Publication date: Available online 4 January 2018
Source:Archives of Oral Biology
Author(s): Dieni da Silveira Teixeira, Maria Antonia Zancanaro de Figueiredo, Karen Cherubini, Maria Claudia Rosa Garcia, Sílvia Dias de Oliveira, Fernanda Gonçalves Salum
ObjectiveThis study investigated the effect of topical application of 0.12% chlorhexidine, 10% povidone-iodine and 50% erythromycin on the optimization of healing process of traumatic ulcers made on ventral tongue of rats.DesignForty-Eight Wistar rats were randomly divided into four groups: control, chlorhexidine (Chx), povidone-iodine (PvI) and erythromycin (Er). An ulcer of 5 mm in diameter was made on the ventral tongue of the animals. After 24 h, a microbiological sample was taken and daily application of the substances started. Six animals each group were euthanized at 4 days and the others at 8 days postoperative, totaling three and seven days of treatment. Prior to euthanasia, a new microbiological collection was performed.ResultsThe experimental groups showed less area of residual ulcer. A significant difference was seen between the PvI and Chx in relation to the control after three days of treatment (p<0.05). Although the experimental groups displayed greater newly formed epithelial area, there was no significant difference compared to the control (p>0.05). Er exhibed the lowest inflammation scores after seven days of treatment (p = 0.05). PvI showed reduction of microorganisms at both times and under aerobic (p < 0.01 at 3 days and p < 0.001 at 7 days) and microaerophilic (p<0.05) conditions. Er significantly reduced the count of microorganisms in aerobic condition when compared to control group (p<0.05 at 3 days and p<0.01 at 7 days).ConclusionsAll drugs promoted reduction of the microorganisms at the site of the injury, which may have a direct effect on the tissue repair process.



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