Pentoxifylline, Tocopherol and Clodronate for the treatment of mandibular osteoradionecrosis: A systematic review

Publication date: Available online 14 February 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Miriam Martos-Fernández, Manel Saez-Barba, Jose López-López, Albert Estrugo-Devesa, Jose María Balibrea-del-Castillo, Coro Bescós-Atín
ObjetiveThe purpose of this article is to evaluate the healing benefit of provided by combining Pentoxifylline-Tocopherol or Pentoxifylline-Tocopherol-Clodronate for treating osteoradionecrosis due to their antioxidant and antifibritic properties.Study designWe searched for relevant literature in PubMed using a combination of "osteoradionecrosis" and the following keywords: "pentoxifillyne", "tocopherol", "vitamin E" or "clodronate". We considered articles in English or Spanish, with no limitations on the publication date.ResultsThe combination of Pentoxifylline plus Tocopherol +/- Clodronate was found to be effective for the treatment of mandibular osteoradionecrosis although data was generally scarce and mostly consisted of retrospective case series.ConclusionThis drug therapy is well tolerated and could be promising for the treatment of mandibular osteoradionecrosis although prospective randomized controlled clinical trials are needed.



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