The Effect of Unfocused Extracorporeal Shock Wave Therapy on Bone Defect Healing in Diabetics

Aim: The purpose of this study was to evaluate the effect of the unfocused extracorporeal shock wave therapy (ESWT) on healing of mandible ramus defects in diabetic rats. Material and method: Forty male Wistar albino rats were used in the experiment. All animals were randomly divided into 2 main groups, nondiabetic and diabetic. Critical-sized defects were created on ramus in all rats. ESWT was performed to half of rats in each group at 3 sessions after surgery. Animals were euthanized at either fourth or eighth week. Stereological and radiologic examination was performed. Data were statistically analyzed by one-way variance analysis and Tukey post-hoc test. Results: Hounsfield Unit (HU) values were higher in D−E+ group than D−E− group in both 8-week and 4-week groups (P > 0.05). In both 4-week and 8-week diabetic groups, higher value was observed when compared with nondiabetic groups (P > 0.05). According to stereological results, in 4-week groups, there was a higher NB, CT, and NV volume in D−E− group than D−E+ group and in D+E− group than D+E+ group. These results are similar for the 8-week groups except NV volume. Conclusion: It was found that ESWT application has no positive effect on the healing of critical-sized bone defects in nondiabetics whereas promising effects in diabetics were observed. Address correspondence and reprint requests to Enes Özkan, DDs, PhD, Bafra Oral and Dental Health Hospital, 55400, Samsun, Turkey; E-mail: drenesozkan@gmail.com Received 28 April, 2017 Accepted 10 November, 2017 This experimental study was supported by Project Management Office Coordinatorship of Ondokuz Mayis University with PYO.DIS.1904.12.006 project code. The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

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