Biological Evidence Management for DNA Analysis in Cases of Sexual Assault
Biological evidence with forensic interest may be found in several cases of assault, being particularly relevant if sexually related. Sexual assault cases are characterized by low rates of disclosure, reporting, prosecution, and conviction. Biological evidence is sometimes the only way to prove the occurrence of sexual contact and to identify the perpetrator. The major focus of this review is to propose practical approaches and guidelines to help health, forensic, and law enforcement professionals to deal with biological evidence for DNA analysis. Attention should be devoted to av... περισσότερα »
Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer
Abstract MiR-92a was identified as an essential oncogene by promoting the cell proliferation through FBXW7 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-92a (rs9589207) has not been investigated. We found that rs9589207 in miR-92a was involved in the occurrence of GC by acting as a tumor protective factor and was highly associated with tumor size in GC patients instead of tumor number or metastasis in 554 GC patients and 531 cancer-free controls. Besides, the AA genotype in miR-92a could attenuate the promoting... περισσότερα »
Inoculation of paperboard mill sludge versus mixed culture bacteria for hydrogen production from paperboard mill wastewater
Abstract A comparative evaluation of paperboard mill sludge (PMS) versus mixed culture bacteria (MCB) as inoculum for hydrogen production from paperboard mill wastewater (PMW) was investigated. The experiments were conducted at different initial cultivation pHs, inoculums to substrate ratios (ISRs gVS/gCOD), and hydraulic retention times (HRTs). The peak hydrogen yield (HY) of 5.29 ± 0.16 and 1.22 ± 0.11 mmol/gCODinitial was occurred at pH = 5 for MCB and PMS, respectively. At pH of 5, the HY and COD removal achieved the highest values of 2.26 ± 0.14 mmol/gCODinitial and 86 ± 1.6 %... περισσότερα »
Uptake of polybrominated diphenyl ethers by carrot and lettuce crops grown in compost-amended soils
Abstract The uptake of polybrominated diphenyl ethers (PBDEs) by carrot and lettuce was investigated. Degradation of PBDEs in soil in the absence of the plants was discarded. Different carrot (*Nantesa* and *Chantenay*) and lettuce (*Batavia Golden Spring* and *Summer Queen*) varieties were grown in fortified or contaminated compost-amended soil mixtures under greenhouse conditions. After plant harvesting, roots (core and peel) and leaves were analyzed separately for carrot, while for lettuce, leaves and hearts were analyzed together. The corresponding bioconcentration factors (BCF...περισσότερα »
Quinolone co-resistance in ESBL- or AmpC-producing Escherichia coli from an Indian urban aquatic environment and their public health implications
Abstract Quinolone and β-lactam antibiotics constitute major mainstay of treatment against infections caused by pathogenic *Escherichia coli*. Presence of *E. coli* strains expressing co-resistance to both these antibiotic classes in urban aquatic environments which are consistently being used for various anthropogenic activities represents a serious public health concern. From a heterogeneous collection of 61 *E. coli* strains isolated from the river Yamuna traversing through the National Capital Territory of Delhi (India), those harboring *bla* CTX-M-15 (*n* = 10) or *bla* CMY-42... περισσότερα »
Viruses, Vol. 7, Pages 5571-5586: Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase
The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are attenuated in a mouse model of poliovirus. Given these results, it was surprising that the nucleotide incorporation rate and nucleobase fidelity of the Sabin I RdRp is similar to that of wild-type enzyme, although the Sabin I RdRp is less selective against nucleotides with modified sugar gro... περισσότερα »
Viruses, Vol. 7, Pages 5553-5570: Vector-Enabled Metagenomic (VEM) Surveys Using Whiteflies (Aleyrodidae) Reveal Novel Begomovirus Species in the New and OldWorlds
Whitefly-transmitted viruses belonging to the genus Begomovirus (family Geminiviridae) represent a substantial threat to agricultural food production. The rapid evolutionary potential of these single-stranded DNA viruses combined with the polyphagous feeding behavior of their whitefly vector (Bemisia tabaci) can lead to the emergence of damaging viral strains. Therefore, it is crucial to characterize begomoviruses circulating in different regions and crops globally. This study utilized vector-enabled metagenomics (VEM) coupled with high-throughput sequencing to survey begomoviruse... περισσότερα »
Future Internet, Vol. 7, Pages 393-404: Embedding an Identity-Based Short Signature as a Digital Watermark
Digital watermarking aims at protecting multimedia content by hiding into it some data that can be used for such purposes as, for example, intellectual property protection or integrity control. Sometimes, the owner of an image would prefer to not transmit, publish, or hand to a cloud service the original image, but rather an encrypted version of it. Encrypted images allow for less embedding room with respect to their unencrypted counterparts, as there is less spatial correlation to leverage upon. An architecture for embedding as payload the digital signature of an encrypted image,... περισσότερα »
Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb Ischemia/Reperfusion
Limb ischemia/reperfusion (I/R) causes oxidation and inflammation and subsequently induces muscle and kidney injuries. Cepharanthine, a natural plant alkaloid, possesses anti-inflammatory and antioxidative properties. We elucidated the salutary effects of cepharanthine against muscle and kidney injuries following limb I/R. Adult male rats were randomized to receive I/R or I/R plus cepharanthine. I/R was achieved by applying tourniquet high around each thigh for 3 hours followed by reperfusion for 24 hours. Cepharanthine (10 mg/kg, intraperitoneal) was injected immediately before r... περισσότερα »
Association between Albuminuria and Different Body Constitution in Type 2 Diabetes Patients: Taichung Diabetic Body Constitution Study
Objective. Albuminuria in type 2 diabetes mellitus (T2DM) patients increases the risk of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. Because albuminuria is modifiable, identifying relevant risk factors could facilitate prevention and/or management. This cross-sectional study investigated whether body constitution (BC) independently predicts albuminuria. Method. Patients with T2DM () received urinalysis, a blood test, and diabetic retinopathy examination. Albuminuria was defined by an elevated urinary albumin/creatinine ratio (≥30 μg/mg). BC type (... περισσότερα »
Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs
Gastrodin is a bioactive compound extracted from traditional Chinese medicine, Gastrodia elata Bl. It has a definite effect on reducing blood pressure in hypertensive patients. However, the mechanisms of gastrodin in lowering blood pressure still remain unclear. In this study, 4 weeks of administration of gastrodin (100 mg/kg/d intraperitoneally injected) decreased the systolic blood pressure (SBP) in spontaneously hypertensive rats (SHRs) ( versus , ). Among SHRs receiving gastrodin treatment, angiotensin II (Ang II) and aldosterone (ALD) in serum were significantly decreased ( v... περισσότερα »
Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes
Diabetes is a global health problem and a national economic burden. Although several antidiabetic drugs are available, the need for novel therapeutic agents with improved efficacy and few side effects remains. Drugs derived from natural compounds are more attractive than synthetic drugs because of their diversity and minimal side effects. This review summarizes the most relevant effects of various plant-derived natural compounds on the functionality of pancreatic beta cells. Published data suggest that natural compounds directly enhance insulin secretion, prevent pancreatic beta c...περισσότερα »
The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage
Brain injury after intracranial hemorrhage (ICH) results in significant morbidity and mortality. Blood brain barrier (BBB) disruption is a hallmark of ICH-induced brain injury; however, data mirroring BBB disruption in human ICH are scarce. The aim of this study was to assess the significance of circulating biomarkers in evaluating BBB disruption after ICH. Twenty-two patients with ICH were recruited in this study. Concentrations of the tight junction proteins (TJs) Claudin-5 (CLDN5), Occludin (OCLN), and zonula occludens 1 (ZO-1) and vascular endothelial growth factor (VEGF) and ... περισσότερα »
Melodic Contour Training and Its Effect on Speech in Noise, Consonant Discrimination, and Prosody Perception for Cochlear Implant Recipients.
Related Articles *Melodic Contour Training and Its Effect on Speech in Noise, Consonant Discrimination, and Prosody Perception for Cochlear Implant Recipients.* Behav Neurol. 2015;2015:352869 Authors: Lo CY, McMahon CM, Looi V, Thompson WF Abstract Cochlear implant (CI) recipients generally have good perception of speech in quiet environments but difficulty perceiving speech in noisy conditions, reduced sensitivity to speech prosody, and difficulty appreciating music. Auditory training has been proposed as a method of improving speech perception for CI recipients, and recent effo...περισσότερα »
Videofluoroscopic Predictors of Penetration-Aspiration in Parkinson's Disease Patients.
Related Articles *Videofluoroscopic Predictors of Penetration-Aspiration in Parkinson's Disease Patients.* Dysphagia. 2015 Oct 22; Authors: Argolo N, Sampaio M, Pinho P, Melo A, Nóbrega AC Abstract Parkinson's disease (PD) patients show a high prevalence of swallowing disorders and tracheal aspiration of food. The videofluoroscopic study of swallowing (VFSS) allows clinicians to visualize the visuoperceptual and temporal parameters associated with swallowing disorders in an attempt to predict aspiration risk. However, this subject remains understudied in PD populations. Our aim ... περισσότερα »
Auditory Middle Latency Response and Phonological Awareness in Students with Learning Disabilities.
Related Articles *Auditory Middle Latency Response and Phonological Awareness in Students with Learning Disabilities.* Int Arch Otorhinolaryngol. 2015 Oct;19(4):325-30 Authors: Romero AC, Funayama CA, Capellini SA, Frizzo AC Abstract Introduction Behavioral tests of auditory processing have been applied in schools and highlight the association between phonological awareness abilities and auditory processing, confirming that low performance on phonological awareness tests may be due to low performance on auditory processing tests. Objective To characterize the auditory middle late...περισσότερα »
Aspects of Oral Language, Speech, and Written Language in Subjects with Temporal Lobe Epilepsy of Difficult Control.
Related Articles *Aspects of Oral Language, Speech, and Written Language in Subjects with Temporal Lobe Epilepsy of Difficult Control.* Int Arch Otorhinolaryngol. 2015 Oct;19(4):302-8 Authors: Berberian AP, Hopker C, Mazzarotto I, Cunha J, Guarinello AC, Massi G, Crippa A Abstract Introduction About 50 million people have epilepsy and 30% of them have epilepsy that does not respond to properly conducted drug treatment. Objective Verify the incidence of language disorders in oral language, speech, and written language of subjects with difficult to control temporal lobe epilepsy (... περισσότερα »
Orofacial Praxis Abilities in Children with Speech Disorders.
Related Articles *Orofacial Praxis Abilities in Children with Speech Disorders.* Int Arch Otorhinolaryngol. 2015 Oct;19(4):286-92 Authors: Bertagnolli AP, Gubiani MB, Ceron M, Keske-Soares M Abstract Introduction Phonological development occurs in a gradual manner until the age of 7 years. The phonological system is constructed in a similar way for all children, despite presenting some variations in terms of age, paths taken, or repair strategies used. Objective To compare the orofacial praxis abilities of children with typical phonological development (DFT), children with phonet...περισσότερα »
SMAD4 Defect Causes Auditory Neuropathy Via Specialized Disruption of Cochlear Ribbon Synapses in Mice.
Related Articles *SMAD4 Defect Causes Auditory Neuropathy Via Specialized Disruption of Cochlear Ribbon Synapses in Mice.* Mol Neurobiol. 2015 Oct 21; Authors: Liu K, Ji F, Yang G, Hou Z, Sun J, Wang X, Guo W, Sun W, Yang W, Yang X, Yang S Abstract More than 100 genes have been associated with deafness. However, SMAD4 is rarely considered a contributor to deafness in humans, except for its well-defined role in cell differentiation and regeneration. Here, we report that a SMAD4 defect in mice can cause auditory neuropathy, which was defined as a mysterious hearing and speech perc...περισσότερα »
Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller's dementia infantilis, a rare subtype of autism spectrum disorder.
Related Articles *Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller's dementia infantilis, a rare subtype of autism spectrum disorder.* BMC Psychiatry. 2015;15(1):256 Authors: Philippe A, Craus Y, Rio M, Bahi-Buisson N, Boddaert N, Malan V, Bonnefont JP, Robel L Abstract BACKGROUND: Deletions and mutations involving the SHANK3 gene lead to a nonspecific clinical presentation with moderate to profound intellectual disability, severely delayed or absent speech, and autism spectrum disorders (ASD). Better knowledge of the clinical spectrum of SH... περισσότερα »
Literacy transforms speech production.
[image: http:--http://ift.tt/1M8vfzn] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Literacy transforms speech production.* Front Psychol. 2015;6:1458 Authors: Saletta M PMID: 26483721 [PubMed] from Language and Communication Disorders via ola Kala on Inoreader http://ift.tt/1LWfTAt via IFTTT
Suggested Minimum Data Set for Speech Therapy Centers Affiliated to Tabriz University of Medical Sciences.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Suggested Minimum Data Set for Speech Therapy Centers Affiliated to Tabriz University of Medical Sciences.* Acta Inform Med. 2015 Aug;23(4):243-7 Authors: Damanabi S, Abdolnejad S, Karimi G Abstract BACKGROUND: The minimum data considered as a conceptual framework, based on the achievement of effectiveness indicators and it ensures to access of precise and clear health data. The aims of the present study were identified and proposed a data element set of speech therapy centers affiliated with Tabriz University of Medical Sci...περισσότερα »
The Effects of a Voice Education Program on VHI Scores of Elementary School Teachers.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The Effects of a Voice Education Program on VHI Scores of Elementary School Teachers.* J Voice. 2015 Oct 16; Authors: Faham M, Ahmadi A, Drinnan M, Saadatmand N, Fatahi E, Jalalipour M Abstract INTRODUCTION: Teachers seem to be vulnerable to voice disorders because of excessive use of their voice. The purpose of this study was to investigate the effects of a voice education program on the Vocal Handicap Index (VHI) scores of elementary school teachers in the Persian education system. METHOD: This was a semi-experi...περισσότερα »
Long-latency auditory evoked potentials with verbal and nonverbal stimuli.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1Nv6Vcu] Related Articles *Long-latency auditory evoked potentials with verbal and nonverbal stimuli.* Braz J Otorhinolaryngol. 2015 Sep 7; Authors: Oppitz SJ, Didoné DD, da Silva DD, Gois M, Folgearini J, Ferreira GC, Garcia MV Abstract INTRODUCTION: Long-latency auditory evoked potentials represent the cortical activity related to attention, memory, and auditory discrimination skills. Acoustic signal processing occurs differently between verbal and nonverbal stimuli, influencing the latency and ampli... περισσότερα »
Quality of statistical reporting in developmental disability journals.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Quality of statistical reporting in developmental disability journals.* Int J Rehabil Res. 2015 Oct 16; Authors: Namasivayam AK, Yan T, Wong WY, van Lieshout P Abstract Null hypothesis significance testing (NHST) dominates quantitative data analysis, but its use is controversial and has been heavily criticized. The American Psychological Association has advocated the reporting of effect sizes (ES), confidence intervals (CIs), and statistical power analysis to complement NHST results to provide a more comprehensive... περισσότερα »
Prolonged auditory brainstem responses in infants with autism.
[image: http:--media.wiley.com-assets-2250-98-Wi] [image: http:--media.wiley.com-assets-2250-98-Wi] Related Articles *Prolonged auditory brainstem responses in infants with autism.* Autism Res. 2015 Oct 19; Authors: Miron O, Ari-Even Roth D, Gabis LV, Henkin Y, Shefer S, Dinstein I, Geva R Abstract Numerous studies have attempted to identify early physiological abnormalities in infants and toddlers who later develop autism spectrum disorder (ASD). One potential measure of early neurophysiology is the auditory brainstem response (ABR), which has been reported to exhibit prolonged...περισσότερα »
Risk factors for the recurrence of post-semicircular canal benign paroxysmal positional vertigo after canalith repositioning.
[image: http:--production.springer.de-OnlineReso] Related Articles *Risk factors for the recurrence of post-semicircular canal benign paroxysmal positional vertigo after canalith repositioning.* J Neurol. 2015 Oct 17; Authors: Su P, Liu YC, Lin HC Abstract This retrospective study was conducted to determine the relationship between variable factors and the recurrence rate of post-semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) after canalith repositioning procedure (CRP). Patients with PSC-BPPV were diagnosed by history and the presence of a positive Dix-Hallpi... περισσότερα »
An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
Related Articles *An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.* Hum Mol Genet. 2015 Oct 16; Authors: Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, van Woerden GM, Baarends WM, Elgersma Y Abstract UBE2A deficiency syndrome (also known as X-linked intellectual disability type Nascimento) is an intellectual disability syndrome characterized by prominent dysmorphic features, impaired speech and often epilepsy. The syndrome is caused by Xq24 deletions encompassing the UBE2A (HR6A) gene or by intragenic UBE2A mutations. UBE2A enco... περισσότερα »
Early electrophysiological markers of atypical language processing in prematurely born infants.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Early electrophysiological markers of atypical language processing in prematurely born infants.* Neuropsychologia. 2015 Oct 14; Authors: Paquette N, Vannasing P, Tremblay J, Lefebvre F, Roy MS, McKerral M, Lepore F, Lassonde M, Gallagher A Abstract Because nervous system development may be affected by prematurity, many prematurely born children present language or cognitive disorders at school age. The goal of this study is to investigate whether these impairments can be identified early in life using electrophys... περισσότερα »
The Effect of Experience on Response Time When Judging Synthesized Voice Quality.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The Effect of Experience on Response Time When Judging Synthesized Voice Quality.* J Voice. 2015 Oct 13; Authors: Kisenwether JS, Prosek RA Abstract OBJECTIVES/HYPOTHESIS: The purpose of this study was to determine the effect of level and type of experience on response time and the number of replays needed when judging voice quality. STUDY DESIGN: This was a within-subjects group design. METHODS: Speech-language pathologists, singing voice teachers, speech-language pathology graduate students with and without expe... περισσότερα »
Infections Associated With Tunnelled Indwelling Pleural Catheters in Patients Undergoing Chemotherapy
[image: image]Background: Malignant pleural effusions are common complications of advanced malignancies and are associated with significant morbidity and reduced survival. Tunnelled indwelling pleural catheters (TIPCs) are implantable devices used for palliation of symptomatic malignant pleural effusions. Although complication rates are overall low, their use in the setting of concurrent chemotherapy has not been carefully reviewed. We report our experience with infectious complications directly attributable to TIPCs (pleural or local soft tissue infections) in those patients rec... περισσότερα »
Unilateral hyperhidrosis and hypothermia – symptoms of an intrathoracic tumour
A 34-year old man presented at the Department of Dermato-allergology, Herlev and Gentofte Hospital with unilateral hyperhidrosis localized to the right axilla through approximately 10 years without progression of symptoms. The patient often experienced that his right hand was colder than the left, especially during bouts of hyperhidrosis. The symptoms usually arose in stressful situations. The patient had no sensory symptoms (pain and light touch of upper extremitieswere assessed) and no medical history of other diseases including lung disease or neurological disease. This articl...περισσότερα »
Identification of invasive fungal diseases in immunocompromised patients by combining an Aspergillus specific PCR with a multifungal DNA-microarray from primary clinical samples
Summary The increasing incidence of invasive fungal diseases (IFD), most of all invasive aspergillosis (IA) in immunocompromised patients emphasises the need to improve the diagnostic tools for detection of fungal pathogens. We investigated the diagnostic performance of a multifungal DNA-microarray detecting 15 different fungi [*Aspergillus, Candida, Fusarium, Mucor, Rhizopus, Scedosporium* and *Trichosporon* species (spp.)] in addition to an *Aspergillus* specific polymerase chain reaction (PCR) assay. Biopsies, bronchoalveolar lavage and peripheral blood samples of 133 immunocom... περισσότερα »
Acroosteolysis presenting with brachyonychia following exposure to cold
Abstract Background A vast number of conditions ranging from simple trauma to hereditary and collagen vascular disease had been described in association with acroosteolysis. Objective To demonstrate that severe cold exposure not mounting to frostbite may be associated with acroosteolysis. Methods A 16–year-old girl with acroosteolysis presenting with brachyonychia was fully investigated for possible cause of her nail and bone deformity. Results Lab investigations including Parathormone levels, Anti Scl 70, ANA, Anti-CCP and RF levels were all normal. X-ray imaging revealed res... περισσότερα »
Successful treatment of PASH syndrome with infliximab, cyclosporine and dapsone
Abstract Background The group of autoinflammatory syndromes associated with Pyoderma gangrenosum, Acne, and Suppurative Hidradenitis are poorly defined and difficult to control with currently available treatment modalities. Objectives We describe a patient with PASH syndrome and report about the successful multimodal treatment with infliximab, cyclosporine, and dapsone. Methods A review of the available literature to date about this group of autoinflammatory diseases was performed. We performed genetic analysis for PSTPIP1 mutations associated with PAPA syndrome. Results A 22-... περισσότερα »
Chondrocutaneous helix rim advancement flap: two classical and two new modifications for very large defects of the ear
Abstract Background The plastic reconstruction of the ear after microscopically controlled tumor surgery is a particular challenge. The chondrocutaneous helix rim advancement flap (CHRAF) is perfectly suited for the repair of different defects of the helix and even defects beyond. Objective Here, we describe two known and two new modifications of the CHRAF that enlarge the scope of application in tumor surgery of the ear. Methods We demonstrate the different techniques and practical application of the repair and evaluate the benefits and limitations. Results The CHRAF and its ... περισσότερα »
Non-ablative fractional photothermolysis in treatment of idiopathic guttate hypomelanosis
Abstract Background Idiopathic guttate hypomelanosis (IGH) is a common pigmentary disorder affecting a large number of individuals. Many patients seek medical attention due to aesthetic concern. However, no standard treatment is available. Objectives To evaluate the efficacy and side-effects of non-ablative fractional photothermolysis (FP) as a treatment of IGH. Materials and methods A total of 120 lesions from 30 patients with IGH were treated. In each patient, two lesions on the extremities were assigned to treatment group, while lesions from the other side served as control.... περισσότερα »
Gait & Posture
- Recovery of gait after quadriceps muscle fatigue2015-10-26 10:28:39 AM Publication date: Available online 25 October 2015 *Source:*Gait & Posture Author(s): Fabio Augusto Barbieri, Stephannie Spiandor Beretta, Vinicius A.I. Pereira, Lucas Simieli, Diego Orcioli-Silva, Paulo Cezar Rocha dos Santos, Jaap H. van Dieën, Lilian Teresa Bucken Gobbi The aim of this study was to investigate the effect of recovery time after quadriceps muscle fatigue on gait in young adults. Forty young adults (20 to 40 years old) performed three 8-m gait trials at pref... περισσότερα »
The α7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to taxanes
Abstract Gastric cancer is difficult to cure because most patients are diagnosed at an advanced disease stage. Systemic chemotherapy remains an important therapy for gastric cancer, but both progression-free survival and disease-free survival associated with various combination regimens are limited because of refractoriness and chemoresistance. Accumulating evidence has revealed that the homomeric α7-nicotinic acetylcholine receptor (A7-nAChR) promotes human gastric cancer by driving cancer cell proliferation, migration, and metastasis. Therefore, A7-nAChR may serve as a potential... περισσότερα »
Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma
Abstract The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20... περισσότερα »
Long-term outcomes of concurrent chemoradiotherapy versus radiotherapy alone in stage II nasopharyngeal carcinoma treated with IMRT: a retrospective study
Abstract This study aimed to evaluate the efficacy of concurrent chemoradiotherapy (CCRT) for stage II nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). A total of 249 patients were retrospectively reviewed. All patients were treated with IMRT. One hundred forty-three patients treated with CCRT and 106 patients treated with IMRT alone. With a median follow-up of 59.4 months, adding concurrent chemotherapy did not statistically significantly improve the 5-year overall survival (OS) (89.7 % vs 99.0 %, *p* = 0.278), locoregional relapse...περισσότερα »
Benefits and risks of antihypertensive medications in the elderly
Abstract Hypertension is highly prevalent in older age and accounts for a large proportion of cardiovascular (CV) morbidity and mortality worldwide. Isolated systolic hypertension is more common in the elderly than younger adults and associated with poor outcomes such as cerebrovascular disease and acute coronary events. International guidelines are inconsistent in providing recommendations on optimal blood pressure targets in hypertensive elderly patients as a result of the limited evidence in this population. Evidence from clinical trials supports the use of antihypertensive drug... περισσότερα »
Fish oil supplementation does not lower C-reactive protein or interleukin-6 levels in healthy adults
Abstract Background The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may prevent a range of chronic conditions through anti-inflammatory actions. However, as clinical trials using these fatty acids for primary prevention are yet unavailable, their putative role in disease prevention rests, in part, on evidence of anti-inflammatory actions in healthy individuals. Objective To investigate in a double-blind, placebo-controlled clinical trial whether supplementation with a moderate dose of EPA+DHA reduces common biomarkers of chronic, sy... περισσότερα »
T Lymphocyte Plasticity in Autoimmunity and Cancer
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Journal of Oral Rehabilitation
- Clinical importance of median mandibular flexure in oral rehabilitation: a reviewK. Sivaraman, A. Chopra, S. B. Venkatesh, 2015-10-26 10:25:17 AM Summary The mandible has a property to flex inwards around the mandibular symphysis with change in shape and decrease in mandibular arch width during opening and protrusion of the mandible. The mandibular deformation may range from a few micrometres to more than 1 mm. The movement occurs because of the contraction of lateral pterygoid muscles that pulls mandibular condyles medially and causes a sagittal mov... περισσότερα »
Unilateral hyperhidrosis and hypothermia – symptoms of an intrathoracic tumour
A 34-year old man presented at the Department of Dermato-allergology, Herlev and Gentofte Hospital with unilateral hyperhidrosis localized to the right axilla through approximately 10 years without progression of symptoms. The patient often experienced that his right hand was colder than the left, especially during bouts of hyperhidrosis. The symptoms usually arose in stressful situations. The patient had no sensory symptoms (pain and light touch of upper extremitieswere assessed) and no medical history of other diseases including lung disease or neurological disease. This articl... περισσότερα »
Inconclusive role of human papillomavirus infection in breast cancer
Abstract Background Epidemiological studies have examined the association between human papillomavirus (HPV) and breast cancer, but the findings are inconclusive. This study aimed to detect the prevalence of HPV in breast cancer tissue in patients from northeastern China and define the association between HPV and breast cancer using meta-analysis. Methods Polymerase chain reaction (PCR) was used to test cutaneous or mucosal HPV DNA sequence in 77 breast cancer samples and 77 corresponding adjacent normal tissues. The prevalence of HPV in breast cancer was estimated by pooling dat...περισσότερα »
A randomised, phase IIa exploratory trial to assess the safety and preliminary efficacy of LEO 43204 in patients with actinic keratosis
Abstract Background LEO 43204 is a novel ingenol derivative in development for the treatment of actinic keratosis. Objectives To compare safety and preliminary efficacy of three doses of LEO 43204 with ingenol mebutate in actinic keratoses (AKs). Methods Patients with at least three visible, discrete, non-keratotic AKs on four separate selected treatment areas on the forearms received LEO 43204 gel (0.025%, 0.05% and 0.075%) and ingenol mebutate 0.05% gel, by investigator-blinded randomised allocation, for 2 consecutive days. Patients were assessed at 8 weeks. Primary outcomes ... περισσότερα »
A new approach for pre-surgical margin assessment of basal cell carcinoma by reflectance confocal microscopy
Abstract Background Surgical excision represents the elective treatment for BCC. Several non invasive approaches have been proposed for in vivo determination of tumor margin, in order to achieve a radical removal. Objectives We proposed a new approach for lateral margin detection in BCCs through the combination of dermoscopy and Reflectance Confocal Microscopy (RCM). Methods Ten patients with lesions clinically suggestive of non-pigmented BCCs with ill-defined margins were enrolled. All BCCs were first dermoscopically evaluated and the ill-defined margins were marked with a supe...περισσότερα »
Surface air plasma induced cell death and cytokines release of human keratinocytes in the context of psoriasis
Abstract Background Cold atmospheric plasma(CAP) have shown promises for wound healing though little is understood of underpinning mechanisms. Little has been reported so far of their potential treatment of immune-mediated diseases such as psoriasis. Objectives To study CAP-induced cell death and in cytokine release of human keratinocytes as a first assessment of possible CAP use for psoriasis. Methods Using a CAP generator free of energetic ions, we observed its effects on keratinocytes in morphology, cell viability and apoptosis, intracellular and mitochondrial ROS, lysosomal...περισσότερα »
Retrospective study of changes in pharyngeal airway space and position of hyoid bone after mandibular setback surgery by cephalometric analysis
Abstract Background The posterior movement of mandible was known as the main cause of the changes in the pharyngeal airway space (PAS) and the postoperative obstructive sleep apnea (OSA). The purpose of this study was to know the changes of PAS and position of hyoid bone. Methods Lateral cephalographies of 13 patients who had undergone sagittal split ramus osteotomy (SSRO) setback surgery were taken preoperatively (T1), postoperatively within 2 months (T2), and follow-up after 6 months or more (T3). On the basis of F-H plane, diameters of nasopharynx, oropharynx, and hypopharynx ... περισσότερα »
Guidelines for quantification of noise-induced hearing loss in a medicolegal context
Abstract Objectives Guidelines published in 2000 by the authors are widely used by medical and legal professionals in the UK for diagnosis of noise-induced hearing loss (NIHL) in a medicolegal context. However, they cannot be used for quantification of the noise-induced hearing loss, which is required in most cases. This requirement is addressed. Design A method is developed here to quantify NIHL, thereby overcoming this shortcoming. Setting Assessment of NIHL in medicolegal cases. Participants A consecutive series of 124 cases of NIHL is used for evaluation. Main outcome m... περισσότερα »
