Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia
Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies: Abstract PurposeSotatercept may represent a novel approach to the treatment of chemotherapy-induced anemia (CIA). We report the results from two phase 2 randomized studies examining the use of sotatercept for the treatment of CIA in patients with metastatic cancer. MethodsIn study A011-08, patients with metastatic breast cancer were randomi...περισσότερα »
Procedural analgesia with fentanyl buccal tablet in cancer patients for the placement of indwelling central venous access systems
A phase II study on the efficacy and safety of procedural analgesia with fentanyl buccal tablet in cancer patients for the placement of indwelling central venous access systems: Abstract BackgroundPain in cancer patients is often related to oncologic therapies and diagnostic procedures. The placement of fully implantable venous access systems is a very common procedure in oncology patients. Local anaesthesia is the method most commonly used to overcome pain related to this surgical procedure, but the local anaesthetic may be unable to completely eradicate all pain. This study inve...περισσότερα »
Malignancy associated hypercalcaemia-responsiveness to IV bisphosphonates and prognosis in a palliative population
Malignancy associated hypercalcaemia-responsiveness to IV bisphosphonates and prognosis in a palliative population: Abstract BackgroundHypercalcaemia is a potentially fatal paraneoplastic complication of malignancy. It primarily manifests during the advanced phase of cancer, with the life expectancy of patients ranging from weeks to months. The mainstay of treatment is with bisphosphonates, but these are not frequently used in a palliative population due to potential conflict with goals of care. GoalThe goals of this study was to determine the reversibility of hypercalcaemia a... περισσότερα »
Pegteograstim (GCPGC) on chemotherapy-induced neutropenia compared to pegfilgrastim
A randomized, multicenter, phase II/III study to determine the optimal dose and to evaluate the efficacy and safety of pegteograstim (GCPGC) on chemotherapy-induced neutropenia compared to pegfilgrastim in breast cancer patients: KCSG PC10-09: Abstract PurposePegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted to determine the adequate dose of pegteograstim, a new formulation of pegylated G-CSF, and to evaluate t...περισσότερα »
Classification of a palliative care population in a comprehensive cancer centre
Classification of a palliative care population in a comprehensive cancer centre: Abstract PurposeThe purposes of the present study were to classify the palliative care population (PCP) in a comprehensive cancer centre by using information on antineoplastic treatment options and to analyse associations between socio-demographic factors, cancer diagnoses, treatment characteristics and receiving specialist palliative care (SPC). MethodsThis is a cross-sectional screening study of patients with cancer in the Department of Oncology, Rigshospitalet, Copenhagen University Hospital fo... περισσότερα »
Health-related quality of life in patients with metastatic, relapsed, or inoperable squamous cell carcinoma of the head and neck in India
Health-related quality of life in patients with metastatic, relapsed, or inoperable squamous cell carcinoma of the head and neck in India: Abstract ObjectiveThe objective of this study was to evaluate changes in health related quality of life (HRQoL) in patients with metastatic head and neck (H&N) cancer randomized to receive metronomic (methotrexate and celecoxib) or cisplatin chemotherapy. MethodsPatients older than 18 years, with a Karnofsky Performance score of ≥70, and diagnosed with metastatic, locally advanced inoperable or recurrent head and neck (H&N) cancer not amenab...περισσότερα »
Scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies
Pilot evaluation of scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies: Abstract PurposeScrambler therapy is a non-invasive neurocutaneous electrical pain intervention, effective for the treatment of neuropathic pain. Currently, few data about the efficacy of this treatment in cancer pain induced by skeletal and visceral metastases are available. The aim of this single-center case series is to evaluate the efficacy of scrambler therapy in reducing this kind of cancer pain after failure of standard treatments, including pharmacol... περισσότερα »
Weight loss with mindful eating
Weight loss with mindful eating in African American women following treatment for breast cancer: a longitudinal study: Abstract PurposeWomen with higher body mass index (BMI) following breast cancer (BC) treatment are at higher risk of BC recurrence and death than women of normal weight. African American (AA) BC patients have the highest risk of BC recurrence and gain more weight after diagnosis than their white counterparts. The purpose of this study was to evaluate the association between a mindful eating intervention and weight loss in AA women following chemotherapy for BC. ...περισσότερα »
The last week
Age differences in the last week of life in advanced cancer patients followed at home: AbstractA retrospective analysis of a consecutive sample of patients admitted to a home care program was performed. Data were recorded in the last week through a backward analysis from the day before death as follows: 1 week before dying (−1W), 3 days before death (−3D), and the day before dying (−1D). Data to be collected included the Edmonton Symptom Assessment System (ESAS), background pain intensity, the prevalence of breakthrough pain, the use of opioids in the last week, and the need for pa...περισσότερα »
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer: Abstract PurposeOral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can lead to poor clinical outcomes and extensive resource utilisation. The primary aim of this study was to determine the molecular integrity of oral epithelial tight junctions in patients undergoing chemotherapy. The secondary aim was to correlate these changes with proinflammatory cytokines and matrix meta... περισσότερα »
The effect of preventive oral care on treatment outcomes of a cohort of oral cancer patients
The effect of preventive oral care on treatment outcomes of a cohort of oral cancer patients: Abstract PurposeThe purpose of this study was to assess patient adherence to an oral preventive measures (OPM) protocol and its impact on cancer treatment outcomes. MethodsA retrospective cohort of oral cancer of 133 patients submitted to radiotherapy (RT) was selected, excluding those with metastasis. Patients were grouped according to their local tumor response after finishing RT (favorable or unfavorable) and adherence to an OPM (none, ≤6 months, and >6 months). OPM included educat...περισσότερα »
Guideline-based antiemetic therapy on nausea and vomiting control
Measuring the impact of guideline-based antiemetic therapy on nausea and vomiting control in breast cancer patients with multiple risk factors: Abstract PurposeThe objective of this exploratory analysis was to determine if individual patient risk factors could be used to optimize chemotherapy-induced nausea and vomiting (CINV). MethodsThrough validated risk prediction models which quantify patient risk factors, 152 patients with early-stage breast cancer scheduled to received adjuvant anthracycline-based chemotherapy were categorized as being at low (level 0) or high-risk (leve... περισσότερα »
Rehabilitation following treatment for head and neck cancer
“I didn’t actually know there was such a thing as rehab”: survivor, family, and clinician perceptions of rehabilitation following treatment for head and neck cancer: Abstract PurposeThe purpose of this study was to obtain first-hand contributions from survivors, family members, and front-line health care professionals regarding the rehabilitation needs for head and neck cancer (HNC) patients, to inform development of a rehabilitation intervention. MethodsThe researchers conducted a series of focus groups with the three key stakeholder groups. ResultsA total of seven focus g... περισσότερα »
Last month
Treatment of cancer patients in their last month of life: aimless chemotherapy: Abstract PurposeThe use of chemotherapy in the last month of life (CLML) of cancer patients is considered an aggressive approach to be avoided. We examined the practice of CLML in Lebanese cancer patients, and we investigated patient and tumor characteristics that justify this practice. To our knowledge, this is the first study describing CLML of Middle Eastern patients with advanced cancer. MethodsWe conducted this study at Hotel-Dieu de France University Hospital (HDF), Lebanon. Cases eligible fo...περισσότερα »
RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines
RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines: Abstract BackgroundCellular stressors and apoptosis-inducing agents have been shown to induce ribosomal RNA (rRNA) degradation in eukaryotic cells. Recently, RNA degradation in vivo was observed in patients with locally advanced breast cancer, where mid-treatment tumor RNA degradation was associated with complete tumor destruction and enhanced patient survival. However, it is not clear how widespread chemotherapy induced “RNA disruption” is, the extent to which it is associate...περισσότερα »
Seven days in medicine: 20-27 February
NHS financeNHS overspend reaches £2.3bnThe NHS in England overspent by £2.26bn (€2.9bn; $3.2bn) in the first three quarters of this financial year (April to December 2015), figures from the… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1S3mMU2 via IFTTT
Candida albicans Costochondritis after a Complicated Esophagectomy
A Case Report of Candida albicans Costochondritis after a Complicated Esophagectomy: Summary: We present an unusual case of Candida albicans costochondritis after a complicated Ivor Lewis esophagectomy. This case exhibits that pain, erythema, and swelling over the costal cartilages should alert the possibility of infective costochondritis, especially in a postoperative patient. If a fungal agent… Continue reading Candida albicans Costochondritis after a Complicated Esophagectomy
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The horseshoe flap. An “emergency” oncoplastic surgery technique
The horseshoe flap. An “emergency” oncoplastic breast surgery technique: Abstract Since 2003, oncoplastic breast surgery was introduced combining breast cancer resection and reconstruction. The goal of OBS is to achieve an oncologically safe surgery with the best possible cosmetic result. This type of procedure must be carefully planned preoperatively by taking into account several factors.… Continue reading The horseshoe flap. An “emergency” oncoplastic surgery technique
Sixty seconds on . . . vaginal seeding
First of all, what is it?The term describes the use of a gauze swab to transfer maternal vaginal fluid (and therefore vaginal microbiota) onto infants born by caesarean section.Sounds a bit… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1oCCmtE via IFTTT
The NHS: national religion or national football?
In English Premier League football, many more goals are scored from the attacker’s right side than the left.1 Clearly, defenders should be told to spend more time on that side of the pitch. What… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1S3mMTM via IFTTT
Herniation after deep circumflex iliac artery flap
Herniation after deep circumflex iliac artery flap: two cases of rare complication: Abstract Herniation after harvesting of deep circumflex iliac artery (DCIA) flap is a known but not a common complication. It occurs about 2.8 to 9 % according to the literatures and can proceed to a more severe complication such as bowel obstruction. There… Continue reading Herniation after deep circumflex iliac artery flap
Survey ranks Indian cities on cleanliness
Mysuru, Chandigarh, and Tiruchirapalli have come top—while Itanagar, Asansol, and Dhanbad have finished last—in a survey1 that ranked 73 Indian cities on cleanliness and sanitation.The survey, Swachh… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1oCCoBY via IFTTT
Interaction of αβ-Methylene ATP with the Cholinergic Twitch Response in the Guinea-Pig Ileum
In this study, direct effects of the P2X purinoceptor agonist αβ-methylene ATP (αβ-meATP) and effects on the cholinergic twitch response of the electrically stimulated longitudinal muscle-myenteric plexus (LMMP) strip of the guinea-pig ileum, were investigated. αβ-meATP (1, 3, and 10 µmol/l) induced short-lasting contractions on its own, followed by an inhibition of the twitch response… Continue reading Interaction of αβ-Methylene ATP with the Cholinergic Twitch Response in the Guinea-Pig Ileum
The impact of the oral condition of children with sickle cell disease on family quality of life
The impact of the oral condition of children with sickle cell disease on family quality of life: Abstract The aim of this study was to assess the impact of oral conditions of children with sickle cell disease (SCD) on their parents’ quality of life (QoL). A cross-sectional study was performed with parents of outpatients suffering… Continue reading The impact of the oral condition of children with sickle cell disease on family quality of life
Thoracoscopic and laparoscopic radical esophagectomy with left neck anastomosis.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
We described a 50-year-old female, who came to our institute with the diagnosis of esophageal squamous cell carcinoma. The preoperative clinical diagnosis was stage II esophageal squamous cell carcinoma. The minimally invasive esophagectomy (MIE), combined thoracoscopic-laparoscopic esophagectomy with cervical anastomosis, was performed in this case. Total surgery time was 190 min and blood loss was 100 mL. Postoperative pathological exam suggested squamous cell carcinoma, without evidence of lymph node metastasis in any station (T2N0M0 IIb stage). The patient was discharged home ... περισσότερα »
Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients
Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients: Abstract PurposeAs cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. ... περισσότερα »
Results of the modified bi-pectoral muscle flap procedure for post-sternotomy deep wound infection
Results of the modified bi-pectoral muscle flap procedure for post-sternotomy deep wound infection: Abstract PurposePost-sternotomy deep sternal wound infection (DSWI) is a severe complication of cardiac surgery. The introduction of omental and muscle flaps has resulted in a significant decrease in morbidity and mortality. In this article, we present the findings for a series of 55 consecutive patients with DSWI treated using an alternative bi-pectoral musculofascial flap technique. MethodsThe patients were stratified into two groups (one-or two-stage intervention). Patients w... περισσότερα »
Incidence of and risk factors for venous thromboembolism during surgical treatment for esophageal cancer: a single-institution study
Incidence of and risk factors for venous thromboembolism during surgical treatment for esophageal cancer: a single-institution study: Abstract PurposeDuring the treatment of esophageal cancer with curative intent, patients sometimes experience deep vein thrombosis, pulmonary embolism or a central venous catheter-associated thrombus. In this study, we retrospectively reviewed our new-onset esophageal cancer patients and determined the incidence of venous thromboembolism (VTE), the location of the thrombus and the risk factors for VTE. MethodsOne hundred and fifty-three patients ... περισσότερα »
Eurogin Roadmap 2015: How has HPV knowledge changed our practice: vaccines
Eurogin Roadmap 2015: How has HPV knowledge changed our practice: vaccines: Abstract This review is one of two complementary reviews that have been prepared in the framework of the Eurogin Roadmap 2015 to evaluate how knowledge about HPV is changing practices in HPV infection and disease control through vaccination and screening. In this review of HPV vaccine knowledge, we present the most significant findings of the past year which have contributed to our knowledge of the two HPV prophylactic vaccines currently in widespread use and about the recently licensed nonavalent HPV vaccin...περισσότερα »
Study of Cancer’s Origins Reveals Genetic Reprogramming of Single Cells
Study of Cancer’s Origins Reveals Genetic Reprogramming of Single Cells: Researchers have created a model of cancer in zebrafish that allows them to capture live images of tumors forming and growing, in some cases from a single cell. Using the model, the researchers characterized some of the early genetic and epigenetic changes associated with melanoma, the most deadly form of skin cancer. In the fish, an important event in the development of melanoma was the activation, in differentiated pigment-producing cells, of a genetic program that normally occurs during embryonic developmen...περισσότερα »
Presentation of Benefits and Harms in Cancer Screening and Prevention Guidelines
Presentation of Benefits and Harms in US Cancer Screening and Prevention Guidelines: Systematic Review: Background: Cancer prevention and screening guidelines are ideally suited to the task of providing high-quality benefit-harm information that informs clinical practice. We systematically examined how US guidelines present benefits and harms for recommended cancer prevention and screening interventions. Methods: We included cancer screening and prevention recommendations from: 1) the United States Preventive Services Task Force, 2) the American Cancer Society, 3) the American Coll...περισσότερα »
Postoperative radiotherapy in localized primary soft tissue sarcoma
The efficacy of postoperative radiotherapy in localized primary soft tissue sarcoma treated with conservative surgery: Abstract BackgroundTo evaluate the efficacy of postoperative radiotherapy (RT) on local failure-free survival (LFFS), distant metastasis-free survival (DMFS) and overall survival (OS) in patients with localized primary soft tissue sarcoma (STS) and to identify prognostic factors. Methods and materialsBetween January 2000 and July 2010, 220 consecutive patients with localized primary STS, who received conservative surgery with or without postoperative RT, were e... περισσότερα »
High jugular bulb (HJB) in relation to internal acoustic meatus (IAM), round window (RW) and endolymphatic sac
High jugular bulb: different osseous landmarks and their clinical implications: Abstract PurposeThe purpose of this investigation was to compare the rate of high jugular bulb (HJB) in relation to internal acoustic meatus (IAM), round window (RW) and endolymphatic sac and to study their clinical implications. MethodsEighty-seven cadaveric non-pathologic human temporal bones were micro-dissected to expose the jugular fossa (JF) and RW. The minimum distance of JF from RW was measured. On the inner surface of petrous part of temporal bone, minimum vertical distance of JF from IAM a... περισσότερα »
Rheumatoid Arthritis and Adverse Postoperative Outcomes
The Association Between Rheumatoid Arthritis and Adverse Postoperative Outcomes: A Retrospective Analysis.: BACKGROUND: Patients with rheumatoid arthritis have a high overall incidence of mortality, primarily because of cardiovascular complications. Thus, we tested the primary hypothesis that rheumatoid arthritis is independently associated with increased postoperative cardiovascular complications. Second, we determined whether rheumatoid arthritis is associated with increased thromboembolic complications, microcirculatory complications, and mortality. METHODS: We obtained censuses ... περισσότερα »
The impact of glycaemic variability on the surgical patient.
The impact of glycaemic variability on the surgical patient.: Purpose of review: Diabetes is the most prevalent long-term metabolic condition and its incidence continues to increase unabated. Patients with diabetes are overrepresented in the surgical population. It has been well recognized that poor perioperative diabetes control is associated with poor surgical outcomes. The outcomes are worst for those people who were not recognized as having hyperglycaemia. Recent findings: Recent work has shown that preoperative recognition of diabetes and good communication between the clinical...περισσότερα »
Candida albicans Costochondritis after a Complicated Esophagectomy
A Case Report of Candida albicans Costochondritis after a Complicated Esophagectomy: [image: image]Summary: We present an unusual case of Candida albicans costochondritis after a complicated Ivor Lewis esophagectomy. This case exhibits that pain, erythema, and swelling over the costal cartilages should alert the possibility of infective costochondritis, especially in a postoperative patient. If a fungal agent is identified, aggressive surgical debridement and early commencement of antifungal therapy are likely determinants for a satisfactory outcome.
The Revised Direct Transconjunctival Approach to the Orbital Floor.
The Revised Direct Transconjunctival Approach to the Orbital Floor.: Purpose: To review common surgical approaches to the orbital floor and to evaluate the utility of canthal-sparing, single incision transconjunctival method. Methods: A retrospective chart review of a consecutive series of patients who underwent transconjunctival, direct incision surgery without eyelid dissection or lateral canthotomy and inferior cantholysis and review of the literature were conducted. Results: Twenty-three consecutive patients (33 orbits) were operated using a canthal-sparing direct single cut app... περισσότερα »
The horseshoe flap. An “emergency” oncoplastic surgery technique
The horseshoe flap. An “emergency” oncoplastic breast surgery technique: AbstractSince 2003, oncoplastic breast surgery was introduced combining breast cancer resection and reconstruction. The goal of OBS is to achieve an oncologically safe surgery with the best possible cosmetic result. This type of procedure must be carefully planned preoperatively by taking into account several factors. However, sometimes this does not happen, and as a response to this factors’ neglect, we developed a technique to correct the defect from an upper quadrant breast cancer lumpectomy, which resulted ...περισσότερα »
Herniation after deep circumflex iliac artery flap
Herniation after deep circumflex iliac artery flap: two cases of rare complication: AbstractHerniation after harvesting of deep circumflex iliac artery (DCIA) flap is a known but not a common complication. It occurs about 2.8 to 9 % according to the literatures and can proceed to a more severe complication such as bowel obstruction. There are several factors that exacerbate the risk: surgical factors, operator factor, and patient factors. Surgical factors include large anatomical defect and denervation of related muscles. Operator factor stands for unpunctual suture technique. Pati... περισσότερα »
The impact of the oral condition of children with sickle cell disease on family quality of life
The impact of the oral condition of children with sickle cell disease on family quality of life: Abstract The aim of this study was to assess the impact of oral conditions of children with sickle cell disease (SCD) on their parents’ quality of life (QoL). A cross-sectional study was performed with parents of outpatients suffering from SCD at a hematology referral center in Belo Horizonte, MG. A qualified dentist performed an intraoral exam. The Family Impact Scale (FIS) was used to assess the parents’ perception of QoL. The parents answered some questions regarding sociodemographic ... περισσότερα »
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Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 19 δευτερόλεπτα
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Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis: Abstract Interleukin 17(IL-17) is a pro-inflammatory cytokine produced mainly by Th17 cells. The present study was undertaken to investigate a possible association between IL-17 A genetic polymorphism at (-197A/G) and susceptibility to chronic and localized aggressive periodontitis (LAgP) in an Indian population. The study was carried out on 105 subjects, which included 35 LAgP patients, 35 chronic periodontitis patients and 35 healthy controls. Blood samples were drawn from the s... περισσότερα »
Parafunctional habits are associated cumulatively to painful temporomandibular disorders in adolescents
Parafunctional habits are associated cumulatively to painful temporomandibular disorders in adolescents: Abstract This cross-sectional study was designed to evaluate the effect of sleep bruxism, awake bruxism and parafunctional habits, both separately and cumulatively, on the likelihood of adolescents to present painful TMD. The study was conducted on a sample of 1,094 adolescents (aged 12-14). The presence of painful TMD was assessed using the Research Diagnostic Criteria for Temporomandibular Disorders, Axis I. Data on sleep bruxism, awake bruxism and parafunctional habits (nail/p...περισσότερα »
Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution
Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution: This retrospective study aimed to investigate the recurrence rate of keratocystic odontogenic tumours (KCOTs) treated by enucleation and the application of Carnoy's solution, and to assess the surgical morbidities associated with this treatment. KCOTs treated using a standard protocol of enucleation and the application of Carnoy's solution between 1990 and 2013 were evaluated. One hundred and five KCOTS in 105 patients (54 male, 51 female) ...περισσότερα »
‘Canalization’ of the frontal sinus: a functional approach for the management of post-traumatic sinusitis with lateral bony septa. Report of two cases and long-term follow-up
‘Canalization’ of the frontal sinus: a functional approach for the management of post-traumatic sinusitis with lateral bony septa. Report of two cases and long-term follow-up: The patency of the naso-frontal duct is a key issue in the surgical management of chronic frontal sinusitis. Most of the current operative techniques only provide access to the paramedian portions of the frontal sinus. A canalization approach that allows a functional frontal sinus to be maintained while providing good access to the most lateral areas of the sinus is described herein. Two cases of severe post-t... περισσότερα »
Blanching of facial skin after infiltration of local anaesthetic: an unusual complication of inadvertent intra-arterial injection
Blanching of facial skin after infiltration of local anaesthetic: an unusual complication of inadvertent intra-arterial injection: The blanching of facial skin1 supplied by the maxillary artery is an inadvertent complication of maxillary nerve blocks2 through the greater palatine canal3 and after inferior alveolar nerve blocks.4 To our knowledge, this has not so far been reported after local infiltration anaesthesia.
Suitability of the Patient Concerns Inventory as a holistic screening tool in routine head and neck cancer follow-up clinics
Suitability of the Patient Concerns Inventory as a holistic screening tool in routine head and neck cancer follow-up clinics: In patients with cancer of the head and neck, efficient screening for problems can improve care and the management of resources. We explored use of the Patient Concerns Inventory (PCI-HN) as a holistic screening tool in the follow up of these patients. Between August 2007 and January 2013, 464 patients completed the PCI-HN and the University of Washington Quality of Life questionnaire version 4 (UWQoL) immediately before their routine follow-up consultations. ... περισσότερα »
Haematoma after manual strangulation
Delayed death caused by haematoma after manual strangulation: a rare case: We report the case of a 58-year-old man who had an altercation with his neighbour after drinking. He was seized by the neck, and although he did not complain of any discomfort at the time, he was found dead two hours later.
Nerve injury associated with orthognathic surgery. Part 2: inferior alveolar nerve
Nerve injury associated with orthognathic surgery. Part 2: inferior alveolar nerve: The inferior alveolar nerve (IAN) is the most commonly injured structure during mandibular osteotomies. The prevalence of temporary injury has been reported as 70/100 patients (95% CI 67 to 73/100) or 56/100 nerves (95% CI 46 to 65/100), and the prevalence of permanent alteration in sensation was 33/100 patients (95% CI 30 to 35/100) or 20/100 nerves (95% CI 18 to 21/100) when assessed subjectively. The prevalence varied significantly between different operations (p<0.0001). It was significantly high... περισσότερα »
Quadruple zygomatic implants supported rehabilitation in failed maxillary bone reconstruction
Quadruple zygomatic implants supported rehabilitation in failed maxillary bone reconstruction: AbstractExtreme atrophy of the jaws constitutes a challenge for maxillofacial surgeons. The technique involving Le Fort I osteotomy, bone grafting, and endosseous implants remains the gold standard treatment for class V and class VI atrophy of the maxilla. As severe maxillary atrophy is associated to impaired microvascularization of overlying soft tissues, reconstruction using vascularized free fibula flaps together with endosseous implants is one of the possible treatment plans. When thi... περισσότερα »
Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese
Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese: This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention. All participants were registered for full-mouth clinical attachment level (CAL) and pocket probing depth (PD) measurements, and microbial samples were taken from four sites and analyzed for 18 different bacterial species using the ‘checkerboard’. Serum from each indiv... περισσότερα »
Comparison of fungiform taste-bud distribution among age groups using confocal laser scanning microscopy in vivo in combination with gustatory function
Comparison of fungiform taste-bud distribution among age groups using confocal laser scanning microscopy in vivo in combination with gustatory function: The aim of this study was to compare the distribution of taste buds in fungiform papillae (FP) and gustatory function between young and elderly age groups. Confocal laser scanning microscopy was used because it allows many FP to be observed non-invasively in a short period of time. The age of participants (*n* = 211) varied from 20 to 83 yr. The tip and midlateral region of the tongue were observed. Taste buds in an average of 10 F... περισσότερα »
Oral Moisturizers on Their Antifungal Effects
Impact of Type and Duration of Application of Commercially Available Oral Moisturizers on Their Antifungal Effects: Abstract Purpose To examine the impact of oral moisturizer type and application time on antifungal effects. Materials and Methods Seventeen oral moisturizers (7 liquids, 10 gels) and amphotericin B (AMPH-B) were tested. Antifungal effects were evaluated with newly opened moisturizer samples (0 hour) and with samples incubated for 8 hours to simulate contact during sleep. *Candida albicans* samples (108 cells/ml) were placed into cylindrical holes in 50% trypticase soy ... περισσότερα »
Nickel ion concentrations in the saliva of patients treated with self-ligating fixed appliances: a prospective cohort study
Nickel ion concentrations in the saliva of patients treated with self-ligating fixed appliances: a prospective cohort study: Abstract ObjectiveOrthodontic appliances are considered to be highly biocompatible although adverse effects attributed to the release of nickel ions (Ni2+) have been documented. Self-ligating brackets have grown in popularity for economic reasons and supposed friction reduction. The aim of the present prospective cohort study was therefore to determine salivary Ni2+ concentrations in patients undergoing orthodontic treatment with self-ligating fixed applianc... περισσότερα »
Thrombin Activates Latent TGF{beta}1 via Integrin {alpha}v{beta}1 in Gingival Fibroblasts
Thrombin Activates Latent TGF{beta}1 via Integrin {alpha}v{beta}1 in Gingival Fibroblasts: Transforming growth factor β (TGFβ) regulates cell proliferation, differentiation, migration, apoptosis, and extracellular matrix production. It also plays a pivotal role in the pathogenesis of gingival overgrowth. Thrombin is a key player in tissue repair, remodeling, and fibrosis after an injury, and it exerts profibrotic effects by activating protease-activated receptors. Connective tissue growth factor (CTGF or CCN2) modulates cell adhesion, migration, proliferation, matrix production, a... περισσότερα »
Directly Placed Restorative Materials
Directly Placed Restorative Materials: Review and Network Meta-analysis: For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were included that compared the survival of ≥2 restorative and/or adhesive materials (i.e., no need for restorative reintervention). Pairwise and Bayesian network meta-analyses were performed, with separa... περισσότερα »
Balance between Shrinkage and Hygroscopic Expansion
Effective Expansion: Balance between Shrinkage and Hygroscopic Expansion: The purpose of this study was to investigate the relationship between hygroscopic expansion and polymerization shrinkage for compensation of polymerization shrinkage stresses in a restored tooth. One resin-modified glass-ionomer (RMGI) (Ketac Nano, 3M ESPE), 2 compomers (Dyract, Dentsply; Compoglass, Ivoclar), and a universal resin-based composite (Esthet•X HD, Dentsply) were tested. Volumetric change after polymerization ("total shrinkage") and during 4 wk of water storage at 37°C was measured using an optic...περισσότερα »
Epithelial Microvesicles Promote an Inflammatory Phenotype in Fibroblasts
Epithelial Microvesicles Promote an Inflammatory Phenotype in Fibroblasts: Microvesicles (MVs) are extracellular vesicles secreted by various cell types that are involved in intercellular communication. We hypothesized that in human periodontal disease, the pocket epithelium releases MVs, which then modulate gene expression in the underlying fibroblasts to control periodontal inflammation. MVs were isolated from culture medium of gingival epithelial cells (GECs) treated with oral bacterial biofilm extract or left untreated. Biofilm treatment significantly increased MV release from ... περισσότερα »
Biden tours Duke lab, promotes cancer advances
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QfWs4p via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Northwest Bio Blames Short-Sellers, Not Warning From Expert Doctor, for Stock Plunge
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21j9c4F via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Brain tumor movie – looking for volunteers!
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QfWrgI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Musella Foundation Copay Assistance Program temporarily closed
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21j9bO4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Magnetically Recoverable Cu0/Fe3O4 Catalyzed Highly Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles From Unactivated Terminal Alkynes and Isocyanides
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00459H, Communication Dipak Kumar Tiwari, Phanindrudu Mandalaparthi , Vinod Kumar Aravilli, Sridhar Balasubramanian, PRAVIN R LIKHAR, Dharmendra Kumar Tiwari An efficient, one pot tandem nano Cu0/Fe3O4 catalyzed highly regioselective synthesis of 3-substituted pyrrole-2,4 dicarboxylates from unactivated terminal alkynes and isocyanides has been developed. This strategy exhibits unprecedented double addition... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlom... περισσότερα »
Enantioselective Total Synthesis and Structural Reassignment of (+)-Alsmaphorazine E via a Traceless Chirality Transfer Strategy
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00930A, Communication Kuan Yu, Beiling Gao, Zhaobo Liu, Hanfeng Ding The first enantioselective total synthesis of (+)-alsmaphorazine E has been achieved through a traceless chirality transfer strategy, which also enabled structural reassignment of the natural product. Key features of this... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1p7KCm4 via IFTTT
Immobilization of sulfur in microgels for lithium-sulfur battery
[image: CrossMark.jpg] [image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00489J, Communication Aiping Chang, Qingshi Wu, Xue Du, Shoumin Chen, Jing Shen, Qiuyi Song, Jianda Xie, Weitai Wu Immobilization of sulfur in microgels is achieved via free radical polymerization of commercial poly(ethylene glycol) dimethacrylate in the solution of sulfur-terminated poly(3-oligo(ethylene oxide)4-thiophene), a copolymer prepared by the inverse vulcanization... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on... περισσότερα »
Catalytic Asymmetric Addition of Organolithium Reagents to Aldehydes
Abstract Herein we report an efficient catalytic system for the titanium-promoted enantioselective addition of organolithium reagents to aldehydes, based on chiral Ar-BINMOL ligands. Unprecedented yields and enantioselectivities are achieved in the alkylation reactions of aliphatic aldehydes. Remarkably, methyllithium can be added to a wide variety of aromatic and aliphatic aldehydes, providing versatile chiral methyl carbinol units in a simple one-pot procedure under mild conditions and in very short reaction times. [image: Thumbnail image of graphical abstract] Herein, we report... περισσότερα »
Preakuammicine: A Long-Awaited Missing Link in the Biosynthesis of Monoterpene Indole Alkaloids
Abstract (16*S*)-Preakuammicine has been considered a key intermediate in the biosynthesis of monoterpene indole alkaloids since the 1970s. Indeed, preakuammicine plays a crucial role in the biosynthesis of type II and type III monoterpene indole alkaloids and strychnine. In this paper, we disclose the unprecedented biomimetic transformation of akuammiline into (16*R*)-acetylpreakuammicine, which ultimately gives mechanistic insight into a missing step in biosynthetic pathways. This work affords the first spectroscopic data for this never-described framework. The C16 stereochemistr... περισσότερα »
AntStar: Enhancing Optimization Problems by Integrating an Ant System and Algorithm
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Recently, nature-inspired techniques have become valuable to many intelligent systems in different fields of technology and science. Among these techniques, Ant Systems (AS) have become a valuable technique for intelligent systems in different fields. AS is a computational system inspired by the foraging behavior of ants and intended to solve practical optimization problems. In this […]
Soft Classes and Soft Rough Classes with Applications in Decision Making
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Rough set was defined by Pawlak in 1982. Concept of soft set was proposed as a mathematical tool to cope with uncertainty and vagueness by Molodtsov in 1999. Soft sets were combined with rough sets by Feng et al. in 2011. Feng et al. investigated relationships between a subset of initial universe of soft set […]
Customers, coworkers rally around Colonial Café employee – Kane County Chronicle
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Kane County Chronicle Customers, coworkers rally around Colonial Café employee Kane County Chronicle Just before Thanksgiving, Fodge – who works at the Colonial on Randall Road in St. Charles and used to work at a former location on Route 38 in Geneva – was diagnosed with an advanced stage of tongue cancer. In early December, […]
Reply: Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
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Reply: Essential tremor in ‘The tremulous hand of Worcester: additional comments
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
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Why dentists don’t use rubber dam during endodontics and how to promote its usage?
Abstract Background This survey study aimed at investigating the frequency of rubber dam use during root canal treatment, identifying influencing factors for not using it by Saudi general dental practitioners (GDPs) and endodontists. It also aimed at identifying measures that increase rubber dam usage. Methods After obtaining an ethical approval, two pilot studies were conducted on staff members at Taibah University College of Dentistry and a group of GDPs. A final online survey was constructed comprising 17 close-ended questions divided into six categories: demographics, endodont... περισσότερα »
A general homeostatic principle following lesion induced dendritic remodeling
Abstract Introduction Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood. Results Using computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjust... περισσότερα »
Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD
Abstract Introduction The most common forms of amyotrophic lateral sclerosis and frontotemporal dementia are caused by a large GGGGCC repeat expansion in the first intron of the *C9orf72* gene. The repeat-containing intron should be degraded after being spliced out, however GGGGCC repeat-containing RNA species either accumulate in nuclear foci or are exported to the cytoplasm where they are translated into potentially toxic dipeptide repeat proteins by repeat-associated non-AUG-initiated (RAN) translation. Results In order to determine the mechanisms of repeat-containing intron m... περισσότερα »
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD
Abstract Introduction Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. In vitro Tau-A152T shows a decreased binding to microtubules and a reduced tendency to form abnormal fibers. Results To study the effects of this mutation we generated a mouse model expressing human full-length Tau with this mutation (hTau40AT). At young age (2–3 months) immunohistological analysis reveals pathological Tau conformation and Tau-hype... περισσότερα »
Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1
Abstract Introduction Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer's disease (AD) and vascular dementia. *SORCS1* encodes a protein-sorting molecule genetically linked to both T2D and AD. The association of *SORCS1* with both AD and T2D is sexually dimorphic in humans, with both disease associations showing more robust effects in females. Based on published evidence that manipulation of the mouse genome combining multiple genes related to cerebral amyloidosis, to T2D, or both, might provide novel mouse ...περισσότερα »
Hematological and biochemical reference intervals for Bothrops asper and Crotalus simus (Serpentes: Viperidae), maintained in captivity for venom extraction
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Abstract This study presents hematological and biochemical reference intervals (RIs) for two species of viper snakes (*Bothrops asper* and *Crotalus simus*), which are the first of their type particularly for these two species maintained in captivity and for extraction of venom purposes. A total of 77 snakes were used in developing the study; specifically 39 *B. asper* and 38 *C. simus* snakes. Blood samples were obtained by puncturing the caudal vein, and hematological tests were performed manually by two independent technicians. Plasma biochemistry parameters were determined by a...περισσότερα »
Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don’t Know
Abstract Antibody secretion is executed by plasma cells that are generated in the periphery and migrate to the bone marrow to establish a long lived pool. The terminal differentiation of B lymphocytes into plasma cells is executed by a network of transcription factors that cross-regulate each other in order to irreversibly promote this transition. While… Continue reading Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don’t Know
The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium.
CONCLUSIONS: CXCR4 and cyclooxygenase-2 may play an important role in the recurrence of pterygium. PMID: 26903201 [PubMed – as supplied by publisher] (Source: Ocular Immunology and Inflammation) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QfCCGe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros… Continue reading The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium.
What do women with breast cancer expect from their treatment? Correlates of negative treatment expectations about endocrine therapy
ConclusionNegative treatment expectations before treatment start are mainly associated with psychological variables. These results are relevant for patient education in clinical settings. To improve expectations, clinicians might emphasize treatment efficacy and discuss general and specific medication concerns. Improving treatment knowledge could also be beneficial.Copyright © 2016 John Wiley & Sons, Ltd. (Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros… Continue reading What do women with breast cancer expect from their treatment? Correlates of negative treatment expe... περισσότερα »
Visual Prognosis and Associated Factors of Phacoemulsification and Intraocular Lens Implantation in Different Uveitis Entities in Han Chinese.
CONCLUSIONS: Our current study revealed a generally favorable outcome and associated predictors of phacoemulsification and intraocular lens implantation in uveitic cataracts in Han Chinese. PMID: 26902289 [PubMed – as supplied by publisher] (Source: Ocular Immunology and Inflammation) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QGOp6c via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182… Continue reading Visual Prognosis and Associated Factors of Phacoemulsification and Intraocular Lens ... περισσότερα »
Pancreatic cancer is 4 diseases, each with new treatment possibilities
An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21tlwvV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182… Continue reading Pancreatic cancer is 4 diseases, each with new treatment possibilities
The feedback loop between miR-124 and TGF-{beta} pathway plays a significant role in non-small cell lung cancer metastasis
Increasing evidence shows that micro RNAs (miRNAs) play a critical role in tumor development. However, the role of miRNAs in non-small cell lung cancer (NSCLC) metastasis remains largely unknown. Here, we found that miR-124 expression was significantly impaired in NSCLC tissues and associated with its metastasis. In vitro and in vivo experiments indicate that restoring… Continue reading The feedback loop between miR-124 and TGF-{beta} pathway plays a significant role in non-small cell lung cancer metastasis
Development of DS‐5573a: A novel afucosylated monoclonal antibody directed at B7‐H3 with potent antitu mor activity
This article is protected by copyright. All rights reserved. (Source: Cancer Science) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TAE8Hu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24r0d0q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SWPYNt via IFTTT
Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
For decades most cancers have been treated with a core standard of treatments that include surgery, radiation, and chemotherapy. Now, immunotherapy — a type of treatment that harnesses the patient’s immune system to combat the disease — represents… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TAAo8W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros… Continue reading Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
Editorial Board
(Source: Molecular Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21trHzW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QfN8NN via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SWPW8m via IFTTT
Small-Angle X-ray Scattering Demonstrates Similar Nanostructure in Cortical Bone from Young Adult Animals of Different Species
Abstract Despite the vast amount of studies focusing on bone nanostructure that have been performed for several decades, doubts regarding the detailed structure of the constituting hydroxyapatite crystal still exist. Different experimental techniques report somewhat different sizes and locations, possibly due to different requirements for the sample preparation. In this study, small- and wide-angle X-ray… Continue reading Small-Angle X-ray Scattering Demonstrates Similar Nanostructure in Cortical Bone from Young Adult Animals of Different Species
Obstetric anal sphincter injury as a quality metric: 16-year experience at a single institution
Obstetrics and Gynecology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TAy8P0 via IFTTT
Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients
Journal of Gastroenterology and Hepatology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q3jNZd via IFTTT
Urine biomarkers of kidney injury among adolescents in Nicaragua, a region affected by an epidemic of chronic kidney disease of unknown aetiology
Nephrology Dialysis Transplantation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TAy8yG via IFTTT
Postpartum hemorrhage and use of serotonin reuptake inhibitor antidepressants in pregnancy
Obstetrics and Gynecology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q3jLQW via IFTTT
Nasal intermittent positive pressure ventilation in preterm infants: Equipment, evidence, and synchronization
Seminars in Fetal and Neonatal Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q3jJbN via IFTTT
Effectiveness of early pelviperineal rehabilitation after severe obstetrical injury on the reduction of anal incontinence
European Journal of Obstetrics & Gynecology and Reproductive Biology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q3jJZi via IFTTT
Editorial board
[image: alertIcon.gif] Publication date: March 2016 *Source:*Biological Psychology, Volume 115 from #Medicine via ola Kala on Inoreader http://ift.tt/1QGSWWj Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
What do women with breast cancer expect from their treatment? Correlates of negative treatment expectations about endocrine therapy
ConclusionNegative treatment expectations before treatment start are mainly associated with psychological variables. These results are relevant for patient education in clinical settings. To improve expectations, clinicians might emphasize treatment efficacy and discuss general and specific medication concerns. Improving treatment knowledge could also be beneficial.Copyright © 2016 John Wiley & Sons, Ltd. (Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros… Continue reading What do women with breast cancer expect from their treatment? Correlates of negative treatment expe... περισσότερα »
Editorial Board
(Source: Molecular Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21trHzW via IFTTT
Pancreatic cancer is 4 diseases, each with new treatment possibilities
An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21tlwvV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182… Continue reading Pancreatic cancer is 4 diseases, each with new treatment possibilities
Development of DS‐5573a: A novel afucosylated monoclonal antibody directed at B7‐H3 with potent antitu mor activity
This article is protected by copyright. All rights reserved. (Source: Cancer Science) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TAE8Hu via IFTTT
Case 6-2016: A 10-Year-Old Boy with Abdominal Cramping and Fevers
Presentation of Case. Dr. Hasan Merali (Pediatrics): A 10-year-old boy was seen in the gastroenterology clinic of this hospital because of intermittent abdominal cramping and fevers. The patient had been well until approximately 3 weeks before this presentation, when intermittent fevers to a… from Cancer via ola Kala on Inoreader http://ift.tt/1Owudwe via IFTTT from #Med… Continue reading Case 6-2016: A 10-Year-Old Boy with Abdominal Cramping and Fevers
Instructions_to_Authors
(Source: Carcinogenesis) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21trHjt via IFTTT
Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
For decades most cancers have been treated with a core standard of treatments that include surgery, radiation, and chemotherapy. Now, immunotherapy — a type of treatment that harnesses the patient’s immune system to combat the disease — represents… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TAAo8W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros… Continue reading Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression
Autophagy is a catabolic process that cancer cells usually exploit during stress conditions to provide energy by recycling organelles and proteins. Beyond its prosurvival role, it is well accepted that occurrence of autophagy is often associated with a particular type of programmed cell death known as autophagic cell death (ACD). Dehydroepiandrosterone (DHEA) is an endogenous… Continue reading Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression
The feedback loop between miR-124 and TGF-{beta} pathway plays a significant role in non-small cell lung cancer metastasis
Increasing evidence shows that micro RNAs (miRNAs) play a critical role in tumor development. However, the role of miRNAs in non-small cell lung cancer (NSCLC) metastasis remains largely unknown. Here, we found that miR-124 expression was significantly impaired in NSCLC tissues and associated with its metastasis. In vitro and in vivo experiments indicate that restoring… Continue reading The feedback loop between miR-124 and TGF-{beta} pathway plays a significant role in non-small cell lung cancer metastasis
Intracellular location of BRCA2 protein expression and prostate cancer progression in the Swedish Watchful Waiting Cohort
Prostate cancer patients with inherited BRCA2 mutations have a survival disadvantage. However, it is unknown whether progression is associated with BRCA2 protein expression in diagnostic prostate cancer tissue, among men without inherited mutations. We conducted a nested case–control study within the Swedish Watchful Waiting cohort. The case group included all 71 patients who died from… Continue reading Intracellular location of BRCA2 protein expression and prostate cancer progression in the Swedish Watchful Waiting Cohort
COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global –clinical evaluations, serum biomarkers, genetic studies and neuroimaging– prospective, multicenter, non-interventional, long-term study on Parkinson’s disease progression
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as a global disease (motor and non-motor symptoms); 2) QoL and caregiver issues; 3) Biomark...περισσότερα »
De novo GABRA1 mutations in Ohtahara and West syndromes
Summary Objective *GABRA1* mutations have been identified in patients with familial juvenile myoclonic epilepsy, sporadic childhood absence epilepsy, and idiopathic familial generalized epilepsy. In addition, de novo *GABRA1* mutations were recently reported in a patient with infantile spasms and four patients with Dravet syndrome. Those reports suggest that *GABRA1* mutations are associated with infantile epilepsy including early onset epileptic encephalopathies. In this study, we searched for *GABRA1* mutations in patients with infantile epilepsy to investigate the phenotypic sp... περισσότερα »
Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy
Summary Syntaxin-binding protein 1 (STXBP1) is essential for synaptic vesicle exocytosis. Mutations of its encoding gene, *STXBP1,* are among the most frequent genetic causes of epileptic encephalopathies. However, the precise pathophysiology of *STXBP1* haploinsufficiency has not been elucidated. Using patient-derived induced pluripotent stem cells (iPSCs), we aimed to establish a neuronal model for *STXBP1* haploinsufficiency and determine the pathophysiologic basis for *STXBP1* encephalopathy. We generated iPSC lines from a patient with Ohtahara syndrome (OS) harboring a heteroz... περισσότερα »
Secondary myopathy due to systemic diseases
Background Some systemic diseases also affect the skeletal muscle to various degrees and with different manifestations. This review aimed at summarizing and discussing recent advances concerning the management of muscle disease in systemic diseases. Method Literature review by search of MEDLINE, and Current Contents with appropriate search terms. Results Secondary muscle disease occurs in infectious disease, endocrine disorders, metabolic disorders, immunological disease, vascular diseases, hematological disorders, and malignancies. Muscle manifestations in these categories in...περισσότερα »
Reply: Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion
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Reply: Essential tremor in 'The tremulous hand of Worcester: additional comments
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Reply: Autosomal recessive cerebellar ataxia caused by a homozygous mutation in PMPCA
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Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion
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The nucleo-shuttling of the ATM protein as a basis for a novel theory of radiation response: resolution of the linear-quadratic model*
Volume 92, Issue 3, March 2016, pages 117-131<br>10.3109/09553002.2016.1135260<br>Larry Bodgi from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1LeVMPS via IFTTT
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Volume 92, Issue 3, March 2016, pages 171-171<br>10.3109/09553002.2016.1145896<br> from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1XOssS1 via IFTTT
Early Exposure to Nonnutritive Sweeteners and Long-term Metabolic Health: A Systematic Review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CONTEXT: Nonnutritive sweetener (NNS) consumption is increasing among children, yet its long-term health impact is unclear, particularly when exposure occurs during early life. OBJECTIVE: To synthesize evidence from prospective studies evaluating the association of early-life NNS exposure and long-term metabolic health. DATA SOURCES: Medline, Embase, and Cochrane Library (inception to July 2015). STUDY SELECTION: We […]
Preterm Versus Term Children: Analysis of Sedation/Anesthesia Adverse Events and Longitudinal Risk
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND OBJECTIVES: Preterm and former preterm children frequently require sedation/anesthesia for diagnostic and therapeutic procedures. Our objective was to determine the age at which children who are born <37 weeks gestational age are no longer at increased risk for sedation/anesthesia adverse events. Our secondary objective was to describe the nature and incidence of adverse […]
FDA Clears Extended-Release Tofacitinib (Xeljanz XR) for RAFDA Clears Extended-Release Tofacitinib (Xeljanz XR) for RA
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Xeljanz XR provides a once-daily oral option for patients with moderate to severe rheumatoid arthritis. FDA Approvals (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QfCGpH via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
How Should Physicians Respond to Racist Patients? How Should Physicians Respond to Racist Patients?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A framework for assessing and responding to a patient’s request on the basis of race or ethnicity can help clinicians navigate a painful, yet often inevitable, experience. Medscape Medical News (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QGOsi8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Califf Wins Senate Confirmation Vote on FDA Top Spot Califf Wins Senate Confirmation Vote on FDA Top Spot
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Five months after first being nominated for the post by President Obama, the Senate voted 89 to 4 confirm Dr Robert Califf for commissioner of the FDA. News Alerts (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QfCEhx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Health Tip: Are You Allergic to Dust Mites?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Title: Health Tip: Are You Allergic to Dust Mites?Category: Health NewsCreated: 2/23/2016 12:00:00 AMLast Editorial Review: 2/23/2016 12:00:00 AM (Source: MedicineNet Allergies General) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QGOqXK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Quantitative Evidence of Wear-Off Effect at the End of the Intravenous IgG (IVIG) Dosing Cycle in Primary Immunodeficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Conclusions These findings confirm the existence of decreased efficacy (treatment wear-off) towards the end of a 3–4 week IVIG dosing cycle, and provide a quantifiable evaluation to a phenomenon typically reported anecdotally. For patients experiencing wear-off, increasing the IgG dose or shortening the dosing interval and/or a switch to SCIG may be beneficial. (Source: Journal […]
Autosomal recessive cerebellar ataxia caused by a homozygous mutation in PMPCA
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Essential tremor in 'The tremulous hand of Worcester: additional comments
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Autism: a spectrum of speculation
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Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. *In vivo* sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect different tissue pathophysiological processes. The *in vivo*, non-invasive measuremen... περισσότερα »
Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice
Publication date: Available online 24 February 2016 Source:Vaccine Author(s): Karin Lövgren Bengtsson, Haifeng Song, Linda Stertman, Ye Liu, David C. Flyer, Michael J. Massare, Ren-Huan Xu, Bin Zhou, Hanxin Lu, Steve A. Kwilas, Timothy J. Hahn, Eloi Kpamegan, Jay Hooper, Ricardo Carrion, Gregory Glenn, Gale Smith Ebola virus (EBOV) causes severe hemorrhagic fever for which… Continue reading Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice
European Commission has authorised necitumumab for advanced squamous non-small cell lung cancer
The European Commission has granted a marketing authorisation for necitumumab (Portrazza), for use in combination with gemcitabine and cisplatin chemotherapy for the treatment of adult patients with locally advanced or metastatic epidermal growth factor… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21tlzrE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WKLBTG… Continue reading European Commission has authorised necitumumab for advanced squamous non-small cell lung cancer
Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
For decades most cancers have been treated with a core standard of treatments that include surgery, radiation, and chemotherapy. Now, immunotherapy — a type of treatment that harnesses the patient’s immune system to combat the disease — represents… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TAAo8W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros… Continue reading Genetically engineered immune cell therapy found to boost survival in mice with brain tumours
Drug Resistance to EGFR Inhibitors in Lung Cancer
Conclusions: In the era of precision medicine, oncologists should promptly obtain an accurate diagnosis of drug resistance in each patient to be able to design the most relevant combination therapy to overcome patient-specific drug resistance.Chemotherapy 2015–16;61:223–235 (Source: Chemotherapy) from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QfEHly via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros… Continue reading Drug Resistance to EGFR Inhibitors in Lung Cancer
Researchers develop novel cancer treatment to inhibit chemo-resistance
Despite numerous advances in oncology since the War on Cancer began, many patients develop resistance to standard therapies and eventually relapse. Moffitt Cancer Center researchers hope to improve treatment outcomes with development of a novel… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TAAnBT via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader… Continue reading Researchers develop novel cancer treatment to inhibit chemo-resistance
Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
Abstract Background We aimed to determine if peripheral or central inflammatory cytokines are altered in healthy subjects carrying a leucine-rich repeat kinase 2 (LRRK2) G2019S mutation, and thus genetically at risk of Parkinson’s disease (PD). We also aimed to identify differences in inflammatory cytokines between LRRK2 G2019S-associated and idiopathic PD once the disease manifests. Methods… Continue reading Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
Pancreatic cancer is 4 diseases, each with new treatment possibilities
An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21tlwvV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis… Continue reading Pancreatic cancer is 4 diseases, each with new treatment possibilities
Defining the value framework for prostate brachytherapy using patient-centered outcome metrics and time-driven activity-based costing
Value, defined as outcomes over costs, has been proposed as a measure to evaluate prostate cancer (PCa) treatments. We analyzed standardized outcomes and time-driven activity-based costing (TDABC) for prostate brachytherapy (PBT) to define a value framework. (Source: Brachytherapy) from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Q3rheE via IFTTT
Kartleggingsverktøy for benzodiazepinabstinens nå på norsk
For å følge utviklingen av en abstinenstilstand er objektive mål og gjentatte standardiserte målinger bedre enn kun «beste kliniske skjønn». from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OwFOeC via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VGpSfF via IFTTT
Skin cells reprogrammed to tackle glioblastomas in mice
In a first for medical science, University of North Carolina at Chapel Hill pharmacy researchers turn skin cells into cancer-hunting stem cells that destroy brain tumours known as glioblastoma – a discovery that can offer, for the first time in more than… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1S3djMm via IFTTT from #Med Blogs by… Continue reading Skin cells reprogrammed to tackle glioblastomas in mice
Use of a modified American College of Surgeons trauma quality improvement program to enhance 30-day post-trauma readmission detection
Journal of the American College of Surgeons from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q3jFsF via IFTTT
Experience of damage control trauma laparotomy in a limited resource healthcare setting
International Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TAy6qs via IFTTT
Feasibility and acceptability of clean birth kits containing misoprostol for self-administration to prevent postpartum hemorrhage in rural Papua New Guinea
International Journal of Gynecology & Obstetrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TAy69V via IFTTT
