Hearing preservation in cochlear implant recipients: A cross‐sectional cohort study

xlomafota13 shared this article with you from Inoreader Hearing preservation in cochlear implant recipients: A cross‐sectional cohort study Via Clinical Otolaryngology Abstract Objectives A surge of new developments and research regarding cochlear implants and hearing preservation resulted in several treatment options in the last 5 years. By reviewing our CI population of this period, we aimed to investigate hearing preservation rates and the effect of different treatment options on hearing preservation. Design Retrospectively, all adult cochlear implant recipients with preoperative residual hearing at lower frequencies (threshold <80 dB hearing level) in a single tertiary referral centre between 2015 and 2020 were analysed. Patients were classified into four groups based on their hearing preservation outcome. Subsequently, differences between the four groups regarding several patient dependent and independent factors were investigated. Results In this study, 140 patients were included, which is 46% of all adult CI recipients. Complete hearing preservation was achieved in 14 patients (10%), and complete loss of residual hearing in 48 patients (34%). The lateral wall array and local application of corticosteroids were associated with better hearing preservation. Intravenous corticosteroids, local hyaluronic acid and surgical experience had no effect on hearing preservation rates. Speech perception was not better in patients with residual hearing. Conclusion Approximately half of all adult cochlear implant recipients had residual hearing at lower frequencies before surgery. In current medical practice, only electrode choice seems to have a clear effect on hearing preservation rates. The majority of CI recipients lose their residual hearing after cochlear implantation. Much improvement in treating CI recipients is needed to preserve their residual hearing in the future. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Porokeratosis: a differential diagnosis to consider in benign lichenoid keratosis

xlomafota13 shared this article with you from Inoreader Porokeratosis: a differential diagnosis to consider in benign lichenoid keratosis Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2022 Feb 15;15(2):56-62. eCollection 2022. ABSTRACT Porokeratosis is a disorder of keratinization with many clinical variants. The histological hallmark feature of porokeratosis is a cornoid lamella. Other accompanying features include lichenoid inflammation, atrophy towards the centre of the lesion, dermal cytoid bodies, and adjacent lichenoid changes. Lichenoid keratosis is a benign cutaneous condition, thought to largely represent a degenerating seborrheic keratosis or solar lentigo. The classical histologic appearances are characterized by parakeratosis, epidermal acanthosis, and a dense band of lichenoid lymphocytic infiltrate. Since a lichenoid inflammatory reaction pattern can be seen in porokeratosis it has the potential to be misdiagnosed as a lichenoid keratosis if the cornoid lamella is not identified or missed due to sampling selection. We critically review 104 cases of benign lichenoid keratosis to e stablish whether any of these cases had features to support a diagnosis of porokeratosis. With 9.6% of cases considered for re-classification, we review clues to reaching this histologic diagnosis. PMID:35265253 | PMC:PMC8902476 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pharyngolaryngeal Morbidity With the Laryngeal Mask Airway SupremeTM at Different Fiberoptic Bronchoscopy Grades: An Observational Study

xlomafota13 shared this article with you from Inoreader Pharyngolaryngeal Morbidity With the Laryngeal Mask Airway SupremeTM at Different Fiberoptic Bronchoscopy Grades: An Observational Study Via Journal of Voice To assess whether the different fiberoptic bronchoscopy (FOB) grades of laryngeal mask airway (LMA) Supreme™ affects pharyngolaryngeal morbidity (PLM, including sore throat, dysphonia, pharyngoxerosis, and dysphagia) after general anesthesia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Outcomes Following Vestibular Schwannoma Resection in Patients over the Age of Sixty-five

xlomafota13 shared this article with you from Inoreader Surgical Outcomes Following Vestibular Schwannoma Resection in Patients over the Age of Sixty-five Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/a-1771-0504 Objective Vestibular schwannoma (VS) are benign, often slow growing neoplasms. Some institutions opt for radiosurgery in symptomatic patients of advanced age versus surgical resection. The aim of the study is to analyze surgical outcomes of VS in patients over the age of 65 who were either not candidates for or refused radiosurgery. Methods This includes retrospective analysis of VS patients between 1988 and 2020. Demographics, tumor characteristics, surgical records, and clinical outcomes were recorded. Patient preference for surgery over radiosurgery was recorded in the event that patients were offered both. Facial nerve outcomes were quantified using House-Brackmann (HB) scores. Tumor growth was defined by increase in size of >2 mm. Results In total, 64 patients were included of average age 72.4 years (65–84 years). Average maximum tumor diameter was 29 mm (13–55 mm). Forty-five patients were offered surgery or GKRS, and chose surgery commonly due to radiation aversion (48.4%). Gross total resection was achieved in 39.1% (n = 25), near total 32.8% (n = 21), and subtotal 28.1% (n = 18). Average hospitalization was 5 days [2–17] with 75% (n = 48) discharged home. Postoperative HB scores were good (HB1–2) in 43.8%, moderate (HB3–4) in 32.8%, and poor (HB5–6) in 23.4%. HB scores improved to good in 51.6%, moderate in 31.3%, and remained poor in 17.1%, marking a rate of facial nerve improvement of 10.9%. Tumor control was achieved in 95.3% of cases at an average follow-up time of 37.8 months. Conclusion VS resection can be safely performed in patients over the age of 65. Advanced age should not preclude a symptomatic VS patient from being considered for surgical resection. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Minipterional Approach for Middle Fossa Skull Base Lesions: Technical Note

xlomafota13 shared this article with you from Inoreader Minipterional Approach for Middle Fossa Skull Base Lesions: Technical Note Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0042-1743464 Surgical access to the middle fossa can be technically challenging. As neurosurgery evolves to minimally invasive approaches, the objective of this study is to demonstrate the extension of the Minipterional approach to access the middle fossa. We present a new surgical approach to the middle fossa for the treatment of secondary trigeminal neuralgia. Three cases are reported to illustrate the following techniques: a patient with petrotentorial meningioma and trigeminal neuralgia, a patient with an arachnoid cyst compressing the fifth nerve, and a patient with a middle cerebral artery aneurysm and a long history of TN (trigeminal neuralgia) refractory to medical and surgica l treatments. All three experienced full symptom controls with no permanent neurological deficits. Therefore, the Minipterional technique might represent a feasible, effective, and safe option to treat refractory secondary TN. It also allows approaching these lesions when the posterior fossa approach is compromised by anatomical distortion and enables the simultaneous treatment of secondary trigeminal neuralgia and other lesions, such as aneurysms and meningiomas. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comprehensive Analysis of the Prognosis and Drug Sensitivity of Differentiation-Related lncRNAs in Papillary Thyroid Cancer

xlomafota13 shared this article with you from Inoreader Comprehensive Analysis of the Prognosis and Drug Sensitivity of Differentiation-Related lncRNAs in Papillary Thyroid Cancer Via radioactive iodine Cancers (Basel). 2022 Mar 7;14(5):1353. doi: 10.3390/cancers14051353. ABSTRACT Dedifferentiation is the main concern associated with radioactive iodine (RAI) refractoriness in patients with papillary thyroid cancer (PTC), and the underlying mechanisms of PTC dedifferentiation remain unclear. The present work aimed to identify a useful signature to indicate dedifferentiation and further explore its role in prognosis and susceptibility to chemotherapy drugs. A total of five prognosti c-related DR-lncRNAs were selected to establish a prognostic-predicting model, and corresponding risk scores were closely associated with the infiltration of immune cells and immune checkpoint blockade. Moreover, we built an integrated nomogram based on DR-lncRNAs and age that showed a strong ability to predict the 3- and 5-year overall survival. Interestingly, drug sensitivity analysis revealed that the low-risk group was more sensitive to Bendamustine and TAS-6417 than the high-risk group. In addition, knockdown of DR-lncRNAs (DPH6-DT) strongly promoted cell proliferation, invasion, and migration via PI3K-AKT signal pathway in vitro. Furthermore, DPH6-DT downregulation also increased the expression of vimentin and N-cadherin during epithelial-mesenchymal transition. This study firstly confirms that DR-lncRNAs play a vital role in the prognosis and immune cells infiltration in patients with PTC, as well as a predictor of the drugs' chemosensitivity. Based on our resul ts, DR-lncRNAs can serve as a promising prognostic biomarkers and treatment targets. PMID:35267662 | DOI:10.3390/cancers14051353 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls

xlomafota13 shared this article with you from Inoreader The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 10. doi: 10.1007/s00405-022-07326-6. Online ahead of print. ABSTRACT Salivary gland tumors are diagnostically challenging owing to the morphological diversity within any tumor type and overlapping histomorphology and immunohistochemistry amongst different tumours. In past two decades, rapid progress has been made in the field of understanding the pathogenesis of these tumours with the discovery of many tumour specific translocations and rearrangements. This includes CRTC1-MAML2 and CRTC-MAML2 in mucoepidermoid carcinoma, MYBNFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 in pleomorphic adenoma, ETV6-NTRK3 in secretory carcinoma, NR4A3 rearrangements in acinic cell carcinoma, PRKD1 mutations in polymorphous adenocarcinoma and EWSR1-ATF1 in clear cell carcinoma. This review is a lens for progress made till date in the molecular pathology of salivary gland tumours with a special focus on their role as diagnostic tools and implications on clinical management of the patient as prognostic and predictive markers. PMID:35267084 | DOI:10.1007/s00405-022-07326-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.