Antioxidant Supplements as Adjuvant Therapy
Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review: Oxidative stress is a key component in carcinogenesis. Although radiation produces reactive oxygen species, some anticancer agents such as alkylating agents, platinum and antitumor antibiotics exert cytotoxicity by generating free radicals. Nonenzymatic exogenous antioxidants such as vitamins, minerals, and polyphenols can quench ROS activity. However, whether antioxidants alter antitumor effects during radiotherapy and some types of chemotherapy remains unclear. In the... περισσότερα »
Clinical significance of serum claudin-1 levels in melanoma patients.
Clinical significance of serum claudin-1 levels in melanoma patients.: Claudins are the most important structural and functional components of tight-junction integral membrane proteins. They play roles in major cellular functions including growth and adhesion and are responsible for regulating the paracellular transport of molecules. The objective of this study was to determine the clinical significance of the serum levels of claudin-1, an oldest and important member of the claudin family, in melanoma patients. A total of 98 patients with a pathologically confirmed melanoma were enr... περισσότερα »
The Association Between Radiation Therapy and Survival for Surgically Resected Soft-Tissue Sarcoma.
A Meta-Analysis of the Association Between Radiation Therapy and Survival for Surgically Resected Soft-Tissue Sarcoma.: Objectives: Radiotherapy for soft-tissue sarcoma (STS) has been shown to reduce local recurrence, but without clear improvement in survival. We conducted a meta-analysis to study the association between radiotherapy and survival in patients undergoing surgery for STS. Methods: A systematic review was conducted from PubMed, EMBASE, Web of Science, and Cochrane databases. Our population of interest consisted of adults with primary extremity, chest wall, trunk, or bac... περισσότερα »
Medicare Cancer Screening
Medicare Cancer Screening in the Context of Clinical Guidelines: 2000 to 2012.: Objectives: Cancer screening is a ubiquitous and controversial public health issue, particularly in the elderly population. Despite extensive evidence-based guidelines for screening, it is unclear how cancer screening has changed in the Medicare population over time. We characterize trends in cancer screening for the most common cancer types in the Medicare fee-for-service (FFS) program in the context of conflicting guidelines from 2000 to 2012. Materials and Methods: We performed a descriptive analysis ... περισσότερα »
Discussing fertility preservation with young patients
Healthcare professionals' views on discussing fertility preservation with young cancer patients: a mixed method systematic review of the literature: Abstract Objective In spite of efforts to guarantee patients are adequately informed about their risk of fertility loss and offered treatment for fertility preservation (FP), previous studies have reported that this topic is not routinely discussed with patients, especially with younger patient populations. A mixed method systematic review was undertaken to explore the factors shaping the discussion of FP with children (0–15 years) and ... περισσότερα »
Social Media and the Adolescent and Young Adult (AYA) Patient
Social Media and the Adolescent and Young Adult (AYA) Patient with Cancer: AbstractOver 70,000 adolescent and young adults (AYA) aged 15 to 39 years are diagnosed with cancer each year in the US. The National Cancer Institute (NCI) has identified AYA cancer patients as a unique population. The most common cancers in this age group include tumors typically seen in pediatric patients such as acute lymphoblastic leukemia (ALL) and brain tumors, as well as cancers more typically seen in adult patients such as breast cancer and melanoma. In addition, some cancers have their highest inci... περισσότερα »
Familial atypical multiple mole melanoma (FAMMM) syndrome
Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity: AbstractApproximately 5–10 % of cutaneous melanoma occurs in kindreds with a hereditary predisposition. Mutations in the *CDKN2A* gene are found to occur in approximately 20–40 % of these kindreds. The first historical mention of what is now called the familial atypical multiple mole melanoma syndrome appears to be from 1820, with more reports throughout the 1950s, 1960s, and later years. In 1991, Lynch and Fusaro described an association between familial multiple mole melanoma and panc... περισσότερα »
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy: AbstractPreviously, we combined p19Arf (*Cdkn2a*, tumor suppressor protein) and interferon beta (IFN-β, immunomodulatory cytokine) gene transfer in order to enhance cell death in a murine model of melanoma. Here, we present evidence of the immune response induced when B16 cells succumbing to death due to treatment with p19Arf and IFN-β are applied in vaccine models. Use of dying cells for prophylactic vaccination was investigated, id... περισσότερα »
Cancers, Vol. 8, Pages 23: Association between Genetic Variants in DNA Double-Strand Break Repair Pathways and Risk of Radiation Therapy-Induced Pneumonitis and Esophagitis in Non-Small Cell Lung Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Radiation therapy (RT)-induced pneumonitis and esophagitis are commonly developed side effects in non-small cell lung cancer (NSCLC) patients treated with definitive RT. Identifying patients who are at increased risk for these toxicities would help to maximize treatment efficacy while minimizing toxicities. Here, we systematically investigated single nucleotide polymorphisms (SNPs) within double-strand break (DSB) repair pathway […]
Evidence mounts for interbreeding bonanza in ancient human species
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Nature tallies the trysts among Neanderthals, humans and other relatives. Nature News doi: 10.1038/nature.2016.19394 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24bUlbf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Changes in dermal matrix in the absence of Rac1 in keratinocytes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Keratinocytes, in response to irritants, secrete pro-inflammatory mediators which recruit and activate immune and mesenchymal cells, including fibroblasts, to repair the skin. Fibroblasts respond by synthesising collagen and promoting the crosslinking extracellular matrix (ECM). We recently showed that the deletion of Rac1 in keratinocytes causes heightened inflammation due to aberrant crosstalk with immune cells. […]
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Abstract Previously, we combined p19Arf (Cdkn2a, tumor suppressor protein) and interferon beta (IFN-β, immunomodulatory cytokine) gene transfer in order to enhance cell death in a murine model of melanoma. Here, we present evidence of the immune response induced when B16 cells succumbing to death due to treatment with p19Arf and IFN-β are applied in vaccine […]
Viruses, Vol. 8, Pages 52: Infectious Salmon Anaemia Virus (ISAV) RNA Binding Protein Encoded by Segment 8 ORF2 and Its Interaction with ISAV and Intracellular Proteins
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Infectious salmon anaemia virus (ISAV) is an orthomyxovirus infecting salmonid fish. The virus is adapted to low temperature and has a replication optimum between 10–15 °C. In this study the subcellular localization and protein interactions for the protein encoded by the largest open reading frame of gene segment 8 (s8ORF2) were investigated. In ISAV infected […]
Correction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
The paper Nikesitch, N. & Ling, S. C. 2015. Molecular mechanisms in multiple myeloma drug resistance. J Clin Pathol. Published in November 2015 has been updated to reflect the change in name of Western Sydney University. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SB1PAx via IFTTT
Clinical and laboratory characteristics of acute myeloid leukaemia (AML) at relapse and the risk of acute incapacitation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
There is limited published data on the mode of relapse presentation in acute myeloid leukaemia (AML) and the efficacy of routine outpatient monitoring in detecting relapse. In diffuse large B cell lymphoma, studies looking at postremission surveillance imaging found that the majority of relapses were detected at patient self-presentation;1 however, there is no similar data […]
Biopsy interpretation of soft tissue tumours, second edition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
This book is the 2nd edition of soft tissue tumours from the illustrious Biopsy Interpretation series. As I am not acquainted with the first edition, this review will be based entirely on this iteration of the book. I would like to start by saying that this book truly emerges like a ‘good deed in a […]
Role of immunohistochemistry in the era of genetic testing in MYC-positive aggressive B-cell lymphomas: a study of 209 cases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Aims MYC rearrangements with or without BCL2 rearrangements have been shown to be associated with poor prognosis and inferior survival in diffuse large B-cell lymphomas (DLBCL). Most of these cases are still diagnosed by fluorescent in situ hybridisation (FISH) testing, which is expensive, requires expertise and is not routinely available in all laboratories. Immunohistochemistry (IHC) […]
Quality assessment and preservation of RNA from biobank tissue specimens: a systematic review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
It is well recognised that genomic, proteomic and biomarker studies require properly annotated and well-characterised biospecimens. Consequently, this necessitates biobanks to collect, store and distribute biospecimens under stringent quality control and assurance measures. However, despite this realisation, there remains a lack of standardisation in quality management among biobanks and consensus as to which quality indicators […]
Radiation Therapy-Induced Pneumonitis and Esophagitis
Cancers, Vol. 8, Pages 23: Association between Genetic Variants in DNA Double-Strand Break Repair Pathways and Risk of Radiation Therapy-Induced Pneumonitis and Esophagitis in Non-Small Cell Lung Cancer: Radiation therapy (RT)-induced pneumonitis and esophagitis are commonly developed side effects in non-small cell lung cancer (NSCLC) patients treated with definitive RT. Identifying patients who are at increased risk for these toxicities would help to maximize treatment efficacy while minimizing toxicities. Here, we systematically investigated single nucleotide polymorphisms (SNPs) ... περισσότερα »
Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Radiotherapy (IMRT) for Oropharyngeal Cancer
: First Comparative Results of Patient-Reported Outcomes via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 18 February 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Terence T. Sio, Huei-Kai Lin, Qiuling Shi, G. Brandon Gunn, Charles S. Cleeland, J. Jack Lee, Mike Hernandez, Pierre Blanchard, Nikhil G. Thaker, Jack Phan, David I. Rosenthal, Adam S. Garden, William H. Morrison, C. David Fuller, Tito R. Mendoza, Radhe Mohan, Xin Shelley Wang, Steven J. Frank PurposeWe hypothesized that patients with oro... περισσότερα »
Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma
Long-term Outcomes after via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 18 February 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): A.L. Russo, J. Adams, E.A. Weyman, P.M. Busse, S.I. Goldberg, M. Vavares, D.T. Lin, D.G. Deschler, T.F. Delaney, A.W. Chan PurposeSquamous cell carcinoma (SCC) is the most common sinonasal cancer and is associated with one of the worse outcomes. Proton therapy allows excellent target coverage with maximal sparing of adjacent normal tissues. We evaluated long-term outco... περισσότερα »
Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future
Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future: AbstractThe field of plasma medicine has seen substantial advances over the last decade, with applications developed for bacterial sterilisation, wound healing and cancer treatment. Low temperature plasmas (LTPs) are particularly suited for medical purposes since they are operated in the laboratory at atmospheric pressure and room temperature, providing a rich source of reactive oxygen and nitrogen species (RONS). A great deal of research has been conducted into the role of react... περισσότερα »
Toll-like receptor 5 and 7 expression in adenoid cystic carcinoma of major salivary glands
Toll-like receptor 5 and 7 expression in adenoid cystic carcinoma of major salivary glands: AbstractAdenoid cystic carcinoma (ACC) of the salivary glands has a poor long-term prognosis and high metastatic rate. Toll-like receptors (TLRs) have been related to tumour progression but have also tumour growth-inhibiting responses. To the best of our knowledge, they have not been studied previously in ACC. We studied the immunoexpression of TLR 5 and 7 in ACC of the major salivary glands. From a cohort of 54 patients with ACC of the major salivary glands treated at the Department of Oto... περισσότερα »
Perlecan-binding growth factors in epithelial dysplasia, carcinoma in-situ, and squamous cell carcinoma of the oral mucosa
Differential immunohistochemical expression profiles of via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 17 February 2016 *Source:*Pathology - Research and Practice Author(s): Mayumi Hasegawa, Jun Cheng, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Hamzah Babkair, Chikara Saito, Takashi Saku The intercellular deposit of perlecan, a basement-membrane type heparan sulfate proteoglycan, is considered to function as a growth factor reservoir and is enhanced in oral epithelial dysplasia and carcinoma in-situ (CIS). However, it remains un... περισσότερα »
True fenestration of the anterior communicating artery diagnosed by magnetic resonance angiography
True fenestration of the anterior communicating artery diagnosed by magnetic resonance angiography: AbstractVariations of the anterior cerebral artery–anterior communicating artery (ACoA) complex are common. Most are duplicated or partially duplicated ACoAs that are confused with fenestration of the ACoA. We report here an extremely rare case of true fenestration of the ACoA diagnosed by magnetic resonance angiography. Tiny true fenestrations of the ACoA may be overlooked easily by MR angiography. Partial maximum-intensity-projection image and volume-rendering image are useful in i... περισσότερα »
Protective Effects of Nigella Sativa on Gamma Radiation-Induced Jejunal Mucosal Damage
in Rats via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 17 February 2016 *Source:*Pathology - Research and Practice Author(s): Mehmet Kanter, Cem Uzal, Mustafa Erboga, Mumtaz Takir, Osman Kostek IntroductionThe aim of this study was to compare the efficacy of Nigella sativa in protection of jejunal mucosa against harmful effects of gamma radiation.MethodsRadiotherapy group received abdominal gamma radiation of 15Gy in addition to physiological saline. Radiotherapy+Nigella sativa treatment group received abdominal gamma radiation of 1... περισσότερα »
Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles
Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles: *Aim*. Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. *Materials and Meth... περισσότερα »
Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Retropharynx)
Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Uncommon Locations (Heart and Retropharynx): We report two cases of malignant peripheral nerve sheath tumor (MPNST) in an uncommon location (heart and retropharynx) both with divergent osseous heterologous differentiation. We present the pathological and immunohistochemical studies that confirmed the neurogenic origin. The histopathology of the tumor arising in the retropharynx showed a transition from a neurofibroma to MPNST, making this a new report of an MPNST arising from a plexiform neurofibro... περισσότερα »
Mechanisms and therapeutic effectiveness of lactobacilli
Mechanisms and therapeutic effectiveness of lactobacilli: The gut microbiome is not a silent ecosystem but exerts several physiological and immunological functions. For many decades, lactobacilli have been used as an effective therapy for treatment of several pathological conditions displaying an overall positive safety profile. This review summarises the mechanisms and clinical evidence supporting therapeutic efficacy of lactobacilli. We searched Pubmed/Medline using the keyword ‘*Lactobacillus*’. Selected papers from 1950 to 2015 were chosen on the basis of their content. Relevan... περισσότερα »
Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma
Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma: Aims The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary body melanoma. Methods The immunohistochemical expression of these markers was evaluated using 3,3'-diaminobenzidine tetrahydrochloride (DAB) and 3-amino-9-ethylcarbazole (AEC) chromogens on paraffin-embedded tissue... περισσότερα »
Biopsy interpretation of soft tissue tumours
Biopsy interpretation of soft tissue tumours, second edition: This book is the 2nd edition of soft tissue tumours from the illustrious Biopsy Interpretation series. As I am not acquainted with the first edition, this review will be based entirely on this iteration of the book. I would like to start by saying that this book truly emerges like a ‘good deed in a bad world’. This skilfully crafted and aesthetically pleasing book is written in a clear, succinct and unambiguous manner and covers a prodigious range of soft tissue tumours. The book opens with an instructive chapter on hand... περισσότερα »
Changes in dermal matrix in the absence of Rac1 in keratinocytes
Changes in dermal matrix in the absence of Rac1 in keratinocytes: Abstract Keratinocytes, in response to irritants, secrete pro-inflammatory mediators which recruit and activate immune and mesenchymal cells, including fibroblasts, to repair the skin. Fibroblasts respond by synthesising collagen and promoting the crosslinking extracellular matrix (ECM). We recently showed that the deletion of Rac1 in keratinocytes causes heightened inflammation due to aberrant crosstalk with immune cells. Indeed, the skin of these mice shows a higher inflammatory response to the induction of irritan... περισσότερα »
Effectiveness of platelet inhibition
Effectiveness of platelet inhibition on major adverse cardiac events in non-cardiac surgery after percutaneous coronary intervention: a prospective cohort study: Background Platelet inhibition is mandatory therapy after percutaneous coronary intervention (PCI). Withdrawal of oral antiplatelet agents has been linked to increased incidence of postoperative adverse cardiac events in post-PCI patients having non-cardiac surgery (NCS). There is limited knowledge of temporal changes in platelet inhibition in this high-risk surgical population. We therefore performed a multicentre prospect... περισσότερα »
Identifying optimal heparin management
Identifying optimal heparin management during cardiopulmonary bypass in obese patients: A prospective observational comparative study.: BACKGROUND: The heparin regimen providing anticoagulation during cardiopulmonary bypass (CPB) is usually adapted to total body weight (TBW), but may be inaccurate in obese patients in whom TBW exceeds their ideal body weight. OBJECTIVES: The objective is to compare the effects of heparin injection based on TBW on haemostatic parameters between obese and nonobese patients during cardiac surgery and to calculate the optimal heparin regimen. DESIGN: Pr... περισσότερα »
Extradural spinal meningioma
Extradural spinal meningioma: Revisiting a rare entity: *Guruprasad Bettaswamy, Paurush Ambesh, Kuntal Kanti Das, Rabi Sahu, Arun Srivastava, Anant Mehrotra, Awadhesh Jaiswal, Sushila Jaiswal, Sanjay Behari* Journal of Craniovertebral Junction and Spine 2016 7(1):65-68 Spinal meningiomas are mostly intradural in location although at times these are associated with some extradural extensions. Purely extradural spinal meningiomas (EDSMs) are however, extremely rare and when present, may cause diagnostic dilemma preoperatively. Only seven cases of pure EDSM have been reported till ... περισσότερα »
Recurrent craniospinal epidermoid
Recurrent craniospinal epidermoid: A case report: *Abhidha Shah, Manoj Patil, Atul Goel* Journal of Craniovertebral Junction and Spine 2016 7(1):59-61 We present a rare case of a fourth ventricular epidermoid cyst, which recurred 15 years after the initial radical tumor resection surgery. The recurrence of the tumor extended into the cervical spine. The patient was reoperated and a near-total excision of both the cranial and spinal components of the epidermoid was performed. Our literature search did not reveal any case where there was a simultaneous presence of both the cranial... περισσότερα »
Unilateral lag-screw technique for an isolated anterior 1/4 atlas fracture
Unilateral lag-screw technique for an isolated anterior 1/4 atlas fracture: *Semih Keskil, Murat Göksel, Ulas Yüksel* Journal of Craniovertebral Junction and Spine 2016 7(1):50-54 Study Design: Fractures of the atlas are classified based on the fracture location and associated ligamentous injury. Among patients with atlas fractures treated using external immobilization, nonunion of the fracture could be seen. Objective: Ideally, treatment strategy for an unstable atlas fracture would involve limited fixation to maintain the fracture fragments in a reduced position without restri... περισσότερα »
Is atlantoaxial instability the cause of "high" cervical ossified posterior longitudinal ligament? Analysis on the basis of surgical treatment of seven patients
Is atlantoaxial instability the cause of "high" cervical ossified posterior longitudinal ligament? Analysis on the basis of surgical treatment of seven patients: *Atul Goel* Journal of Craniovertebral Junction and Spine 2016 7(1):20-25 Background: Multilevel ossified posterior longitudinal ligaments (OPLLs), particularly those that extend into the high cervical region, are formidable and challenging surgical problems. The aim of the presentation is to analyze the results of surgical treatment of seven consecutive patients having high cervical OPLL with atlantoaxial and subaxial ... περισσότερα »
Cervical orthoses on cervical fracture
Evaluation the efficiency of cervical orthoses on cervical fracture: A review of literature: *Mohammad Taghi Karimi, Mostafa Kamali, Francis Fatoye* Journal of Craniovertebral Junction and Spine 2016 7(1):13-19 Background: Various methods have been used to stabilize the vertebra in cervical fractures, including the use of various orthoses and surgery. However, it is not cleared which type of orthosis is more suitable for the subjects with cervical fractures to best immobilize the vertebra and to decrease the associated side effects. Therefore, the aim of this study was to evalu... περισσότερα »
Unilateral facial injuries caused by horseshoe headrest during prone positional craniovertebral junction surgery
An unusual cause of unilateral facial injuries caused by horseshoe headrest during prone positional craniovertebral junction surgery: *Chetna Shamshery, Rudrashish Haldar, Arun Srivastava, Ashutosh Kaushal, Shashi Srivastava, Prabhat K Singh* Journal of Craniovertebral Junction and Spine 2016 7(1):62-64 Pressure injuries are an accepted complication of prone positioning during the neurosurgical procedures. Horseshoe headrest are intended to reduce the incidence and severity of such injuries by allowing limited areas of contact between the skin of dependent areas of contact and t... περισσότερα »
Minimally invasive space shuttle laminotomy for degenerative lumbar spinal canal stenosis
Minimally invasive space shuttle laminotomy for degenerative lumbar spinal canal stenosis: *Shunji Asamoto, Jun Muto, Hiroyuki Jimbo* Journal of Craniovertebral Junction and Spine 2016 7(1):55-58 Study Design: Technical note. Objectives: To show microsurgical technique, considering the meticulous anatomy of the ligamentum flavum (LF). Background: Different methods are available for treating lumbar spinal canal stenosis (LSCS). A minimally invasive surgery, namely, space shuttle laminotomy, has recently been proposed. Here, we describe the surgical method for this novel technique... περισσότερα »
Central or axial atlantoaxial instability: Expanding understanding of craniovertebral junction
Central or axial atlantoaxial instability: Expanding understanding of craniovertebral junction: *Atul Goel* Journal of Craniovertebral Junction and Spine 2016 7(1):1-3 The atlantoaxial joint is the most mobile joint of the body. Because of a large array of movements that originate from here, there is a larger possibility of the movements becoming abnormal, resulting in instability of the region. Conventionally, atlantoaxial instability has been diagnosed on the basis of abnormal alterations in the atlantodental interval and by radiological evidences of indentation of the odontoi... περισσότερα »
Endoscopic Strip Craniectomy for Craniosynostosis: Do We Really Understand the Indications, Outcomes, and Risks?.
Endoscopic Strip Craniectomy for Craniosynostosis: Do We Really Understand the Indications, Outcomes, and Risks?.: Endoscopic strip craniectomy with postoperative helmet therapy has been introduced as a means to correct various forms of craniosynostosis. Although some authors have deemed the procedure safe and effective, many questions remain regarding this promising yet developing approach. The authors discuss 4 cases where patients were inadequately treated with endoscopic strip craniectomy resulting in a recommendation of complete secondary open cranial vault reconstruction. In a... περισσότερα »
Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy.
Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy.: The aim of this study was to measure the relative location between foramen ovale and internal carotid artery. The results can guide surgeons to avoid damaging internal carotid artery in cavernous sinus biopsy. One hundred twenty people (73 men and 47 women) were involved in this study anonymously. Five parameters of both sides were measured on 2 planes. This study provides data for safer cavernous sinus biopsy. (C) 2016 by Mutaz B. Habal, MD.
The Potential Significance of Concha Bullosa During Nasotracheal Intubation.
The Potential Significance of Concha Bullosa During Nasotracheal Intubation.: The authors experienced a case of severe epistaxis caused by accidental partial middle turbinectomy during nasotracheal intubation, which the patient had bilateral concha bullosa narrowing the nasal airway. Although anesthesiologist checked nasal airway through subjective symptoms and the size of both nostrils, they tend to overlook common anatomic variation, concha bullosa, and can injure turbinate structures. Therefore, preoperative computed tomography images should be carefully evaluated for the possibi... περισσότερα »
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients: Abstract ObjectiveA study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. Material and methodsA prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine... περισσότερα »
Movement control during aspiration with different injection systems via video monitoring—an in vitro model
Movement control during aspiration with different injection systems via video monitoring—an in vitro model: Abstract ObjectivesThe aim of the present study was an evaluation of movement during double aspiration by different manual syringes and one computer-controlled local anesthesia delivery system (C-CLAD)*.* Materials and methodsWith five different devices (two disposable syringes (2, 5 ml), two aspirating syringes (active, passive), one C-CLAD), simulation of double aspiration in a phantom model was conducted. Two experienced and two inexperienced test persons carried out ... περισσότερα »
Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.
Related Articles *Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.* Mod Rheumatol. 2016 Feb 16;:1-7 Authors: Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N Abstract OBJECTIVES: To examine the prevalence and pattern of hand osteoarthritis (HOA), and determine its relationship with grip strength and hand pain. METHODS: Among the participants of the third survey of the Research on Osteoarthritis/Osteo... περισσότερα »
The experiences and needs of individuals with disabilities exposed to chronic political violence.
Related Articles *The experiences and needs of individuals with disabilities exposed to chronic political violence.* Disabil Rehabil. 2016 Feb 16;:1-13 Authors: Shpigelman CN, Gelkopf M Abstract Purpose The main objective of this study was to understand, describe and map the experiences, challenges and needs of individuals with lifelong disabilities, who have been exposed to chronic politically violent events (terror, war or continuous missile attacks) in Israel. Method The study was conducted within the qualitative-constructivist paradigm. Three focus groups consisting of 18 in... περισσότερα »
Changes in dermal matrix in the absence of Rac1 in keratinocytes
Abstract Keratinocytes, in response to irritants, secrete pro-inflammatory mediators which recruit and activate immune and mesenchymal cells, including fibroblasts, to repair the skin. Fibroblasts respond by synthesising collagen and promoting the crosslinking extracellular matrix (ECM). We recently showed that the deletion of Rac1 in keratinocytes causes heightened inflammation due to aberrant crosstalk with immune cells.… Continue reading Changes in dermal matrix in the absence of Rac1 in keratinocytes
Sex-specific regulation of weight and puberty by the Lin28/let-7 axis
Growth and pubertal timing differ in boys and girls. Variants in/near LIN28B associate with age at menarche (AAM) in genome-wide association studies and some AAM-related variants associate with growth in a sex-specific manner. Sex-specific growth patterns in response to Lin28b perturbation have been detected in mice, and overexpression of Lin28a has been shown to alter… Continue reading Sex-specific regulation of weight and puberty by the Lin28/let-7 axis
Current understanding of metformin effect on the control of hyperglycemia in diabetes
Metformin is a first-line oral anti-diabetic agent that has been used clinically to treat patients with type 2 diabetes for over 60 years. Due to its efficacy in therapy and affordable price, metformin is taken by more than 150 million people each year. Metformin improves hyperglycemia mainly through the suppression of hepatic gluconeogenesis along with… Continue reading Current understanding of metformin effect on the control of hyperglycemia in diabetes
The role of bile acids in metabolic regulation
Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel metabolic modulators. They have important endocrine effects through multiple cytoplasmic as well as nuclear receptors in various organs and tissues. BA affect multiple functions to control energy homeostasis, as well as glucose and lipid metabolism, predominantly by activating the nuclear farnesoid… Continue reading The role of bile acids in metabolic regulation
Teen Mom OG’s Maci Bookout on Learning About Surprise Third Pregnancy: ‘Completely Speechless’ – Us Weekly
Us Weekly Teen Mom OG’s Maci Bookout on Learning About Surprise Third Pregnancy: ‘Completely Speechless’ Us Weekly Room for one more! Teen Mom OG’s Maci Bookout announced on Valentine’s Day that she is expecting her second child with fiancé Taylor McKinney, and the reality star tells Us Weekly exclusively that the people close to her… Continue reading Teen Mom OG’s Maci Bookout on Learning About Surprise Third Pregnancy: ‘Completely Speechless’ – Us Weekly
The pituitary TGF{beta}1 system as a novel target for the treatment of resistant prolactinomas
Prolactinomas are the most frequently observed pituitary adenomas and most of them respond well to conventional treatment with dopamine agonists (DAs). However, a subset of prolactinomas fails to respond to such therapies and is considered as DA-resistant prolactinomas (DARPs). New therapeutic approaches are necessary for these tumors. Transforming growth factor β1 (TGFβ1) is a known… Continue reading The pituitary TGF{beta}1 system as a novel target for the treatment of resistant prolactinomas
Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R9EqmA via IFTTT
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
Abstract Previously, we combined p19Arf (Cdkn2a, tumor suppressor protein) and interferon beta (IFN-β, immunomodulatory cytokine) gene transfer in order to enhance cell death in a murine model of melanoma. Here, we present evidence of the immune response induced when B16 cells succumbing to death due to treatment with p19Arf and IFN-β are applied in vaccine… Continue reading Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R9EqmA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1otjYEb via IFTTT
Cancer-causing gene found in plasma may help predict outcomes for head and neck patients – Science Codex
Science Codex Cancer-causing gene found in plasma may help predict outcomes for head and neck patients Science Codex CINCINNATI–Researchers at the University of Cincinnati (UC) have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person’s immune… Continue reading Cancer-causing gene found in plasma may help predict outcomes for head and neck patients – Science Codex
Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis
Publication date: Available online 18 February 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Valentina Flamini, Wen G. Jiang, Jane Lane, Yu-Xin Cui Cancer conveys profound social and economic consequences throughout the world. Metastasis is responsible for approximately 90% of cancer-associated mortality and, when it occurs, cancer becomes almost incurable. During metastatic dissemination, cancer cells pass through a series of complex steps including the establishment of tumour-associated angiogenesis. The human endothelial progenitor cells (hEPCs) are a cell popul... περισσότερα »
Chemical Senses in Cancer Patients.
Related Articles *Chemical Senses in Cancer Patients.* Curr Pharm Des. 2016 Feb 16; Authors: Altundag A, Cayonu M Abstract BACKGROUND: Cancer and its treatment therapies, such as chemotherapy and radiotherapy, have negative effects on taste and smell functions. It is easy to explain smell and taste dysfunctions when a cancer involves the peripheric end organs or neurologic pathways of smell and taste. However, it is difficult to understand how distortion in sensory perception develops as cancer progresses and cancer therapies are applied, because few studies on this subject have... περισσότερα »
Chemical Senses Affecting Cough and Swallowing.
Related Articles *Chemical Senses Affecting Cough and Swallowing.* Curr Pharm Des. 2016 Feb 16; Authors: Ebihara S, Izukura H, Miyagi M, Okuni I, Sekiya H, Ebihara T Abstract BACKGROUND: Dysfunction of swallowing and coughing leads to life-threatening aspiration pneumonia, especially in the elderly. In order to induce the cough and swallowing reflexes efficiently, sensory inputs to trigger the reflexes are essential. METHODS: Both the cough and swallowing reflexes respond to mechanical and chemical stimuli. However, the mechanisms of action of the two reflexes are not homogeneous... περισσότερα »
Design, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents.
Related Articles *Design, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents.* J Org Chem. 2016 Feb 16; Authors: Liu Q, An C, TenDyke K, Cheng H, Shen YY, Hoye AT, Smith AB Abstract The design, synthesis, and biological evaluation of irciniastatin A (1) analogues, achieved by removal of three synthetically challenging structural units, as well as by functional group manipulation of the C(11) substituent of both irciniastatins A and B (1 and 2), has been achieved. To this end, we first designed a convergent s... περισσότερα »
Detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene is influenced by sex and parenting status.
Related Articles *Detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene is influenced by sex and parenting status.* BMC Biol. 2016;14(1):12 Authors: Nakahara TS, Cardozo LM, Ibarra-Soria X, Bard AD, Carvalho VM, Trintinalia GZ, Logan DW, Papes F Abstract BACKGROUND: Olfaction is a fundamental sense through which most animals perceive the external world. The olfactory system detects odors via specialized sensory organs such as the main olfactory epithelium and the vomeronasal organ. Sensory neurons in these organs use G-protein coup... περισσότερα »
Periprocedural Management of Direct Oral Anticoagulants: Comment on the 2015 American Society of Regional Anesthesia and Pain Medicine Guidelines.
Related Articles *Periprocedural Management of Direct Oral Anticoagulants: Comment on the 2015 American Society of Regional Anesthesia and Pain Medicine Guidelines.* Reg Anesth Pain Med. 2016 Feb 13; Authors: Douketis JD, Syed S, Schulman S PMID: 26882272 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1QLkML5 via IFTTT
Diagnostic and therapeutic features associated with modification of quality-of-life's outcomes between one and six months after major surgery for head and neck cancer.
Related Articles *Diagnostic and therapeutic features associated with modification of quality-of-life's outcomes between one and six months after major surgery for head and neck cancer.* Braz J Otorhinolaryngol. 2015 Dec 18; Authors: Gobbo M, Bullo F, Perinetti G, Gatto A, Ottaviani G, Biasotto M, Tirelli G Abstract INTRODUCTION: Treatments used in head and neck cancer greatly impact the physical, psychological and functional state of patients. Evaluation of quality of life has become an integral part of the treatment. OBJECTIVES: This retrospective study evaluates features invol... περισσότερα »
Differentiation of human endometrial stem cells into endothelial-like cells on gelatin/chitosan/bioglass nanofibrous scaffolds.
Related Articles *Differentiation of human endometrial stem cells into endothelial-like cells on gelatin/chitosan/bioglass nanofibrous scaffolds.* Artif Cells Nanomed Biotechnol. 2016 Feb 16;:1-11 Authors: Shamosi A, Mehrabani D, Azami M, Ebrahimi-Barough S, Siavashi V, Ghanbari H, Sharifi E, Roozafzoon R, Ai J Abstract The capacity of gelatin/chitosan/bioactive glass nanopowders (GEL/CS/BGNPs) scaffolds was investigated for increasing human endometrial stem cells (hEnSCs) differentiation into the endothelial cells in the presence of angiogenic factors. GEL/CS nanofibrous scaffol... περισσότερα »
Sentinel lymph node biopsy in breast cancer: a technical and clinical appraisal.
*Sentinel lymph node biopsy in breast cancer: a technical and clinical appraisal.* Nucl Med Commun. 2016 Feb 16; Authors: Manca G, Tardelli E, Rubello D, Gennaro M, Marzola MC, Cook GJ, Volterrani D Abstract Breast cancer is the most common type of cancer diagnosed in women worldwide. Regional lymph node status is one of the strongest predictors of long-term prognosis in primary breast cancer. Sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection as the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-sta... περισσότερα »
Scintigraphic evaluation of renal functional damage in volatile substance abusers.
Related Articles *Scintigraphic evaluation of renal functional damage in volatile substance abusers.* Nucl Med Commun. 2016 Feb 12; Authors: Cayir D, Demirel K, Korkmaz M, Araz M, Koca G Abstract OBJECTIVE: Volatile organic compounds can be maintained easily and can cause dependency. Volatile substance abuse may cause damage by affecting several systems. The aim of our study was to evaluate renal functional damage in volatile substance abusers by diuretic renogram. METHODS: Twenty nine volatile substance abusers and 30 young healthy voluntary young men were included in our study.... περισσότερα »
head and neck; +128 new citations
128 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *head and neck* These pubmed results were generated on 2016/02/18 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1QnJ2T0 via IFTTT
Pyruvate improved insulin secretion status in a mitochondrial diabetes mellitus patient.
*Pyruvate improved insulin secretion status in a mitochondrial diabetes mellitus patient.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154293 Authors: Inoue T, Murakami N, Ayabe T, Oto Y, Nishino I, Goto YI, Koga Y, Sakuta R Abstract CONTEXT: Mitochondrial diabetes is a rare form of diabetes mellitus accounting for up to 1% of all diabetes. Pyruvate therapy has been reported to be a potential therapeutic choice for patients with mitochondrial diseases. CASE DESCRIPTION: Water-based sodium pyruvate solutions (0.5 g/kg, thrice/day) were administrated orally to a 32-year-old Japanese ... περισσότερα »
Low endogenous secretory RAGE levels are associated with inflammation and carotid atherosclerosis in pre-diabetes.
*Low endogenous secretory RAGE levels are associated with inflammation and carotid atherosclerosis in pre-diabetes.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154069 Authors: Di Pino A, Francesca U, Rose Maria Z, Agnese F, Di Mauro S, Piro S, Purrello F, Maria Rabuazzo A Abstract CONTEXT: Pre-diabetes is associated with atherosclerotic vascular damage. OBJECTIVE: We investigated the correlation of endogenous secretory receptor for advanced glycation end-products (esRAGE) and total soluble RAGE (sRAGE) and markers of inflammation, with early cardiovascular disease in subjects with ... περισσότερα »
Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis.
*Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154062 Authors: Espinosa De Ycaza AE, Rizza RA, Sreekumaran Nair K, Jensen MD Abstract CONTEXT: DHEA and testosterone hormones are advertised as anti-aging, anti-obesity products. However, the evidence that these hormones have beneficial effects on adipose tissue metabolism is limited. OBJECTIVE: To determine the effect of DHEA and testosterone supplementation on systemic lipolysis during a mixed meal test (MMTT) and an intravenous glucose tolerance ... περισσότερα »
Vitamin D supplementation does not impact insulin resistance in black and white children.
*Vitamin D supplementation does not impact insulin resistance in black and white children.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20153687 Authors: Ferira AJ, Laing EM, Hausman DB, Hall DB, McCabe GP, Martin BR, Hill Gallant KM, Warden SJ, Weaver CM, Peacock M, Lewis RD Abstract CONTEXT: Vitamin D supplementation trials with diabetes-related outcomes have been conducted almost exclusively in adults and provide equivocal findings. OBJECTIVE: To determine the dose-response of vitamin D supplementation on fasting glucose, insulin and a surrogate measure of insulin resistance in wh... περισσότερα »
CORRIGENDUM.
Related Articles *CORRIGENDUM.* J Clin Endocrinol Metab. 2016 Feb 16;:jc20161043 Authors: PMID: 26881971 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1Q38EZq via IFTTT
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.* Physiol Rev. 2016 Jan;96(1):365-408 Authors: Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G Abstract 1,25-Dihydroxvitamin D3 [1,25(OH)2D3] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH)2D3 action involves the direct binding of the 1,25(OH)2D3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Numerous VDR co-regulatory proteins have b... περισσότερα »
A Middle Cranial Fossa Dermoid Cyst Treated by an Endonasal Endoscopic Approach.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *A Middle Cranial Fossa Dermoid Cyst Treated by an Endonasal Endoscopic Approach.* J Craniofac Surg. 2015 Jun;26(4):e333-5 Authors: Durmaz A, Yildizoğlu Ü, Polat B, Binar M Abstract Dermoid cysts are rare, benign, congenital ectodermal inclusion cysts in the skull base, comprising skin supplements surrounded by squamous epithelium. In the period of embryological development, the cysts originate from ectodermal cells left behind in the cranial region by the closure of the neural tube and are primarily located at th... περισσότερα »
Biology and biotechnology of hyaluronan.
[image: http:--production.springer.de-OnlineReso] Related Articles *Biology and biotechnology of hyaluronan.* Glycoconj J. 2015 May;32(3-4):93-103 Authors: Viola M, Vigetti D, Karousou E, D'Angelo ML, Caon I, Moretto P, De Luca G, Passi A Abstract The hyaluronan (HA) polymer is a critical component of extracellular matrix with a remarkable structure: is a linear and unbranched polymer without sulphate or phosphate groups. It is ubiquitous in mammals showing several biological functions, ranging from cell proliferation and migration to angiogenesis and inflammation. For its critic... περισσότερα »
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.* Toxicol Mech Methods. 2015 Mar;25(3):201-11 Authors: Tarrant JM, Dhawan P, Singh J, Zabka TS, Clarke E, DosSantos G, Dragovich PS, Sampath D, Lin T, McCray B, La N, Nguyen T, Kauss A, Dambach D, Misner DL, Diaz D, Uppal H Abstract Nicotinamide adenine dinucleotide (NAD) is an essential co-factor in glycolysis and is a key molecule involved in maintaining cellular energy metaboli... περισσότερα »
Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells.* Sci Rep. 2015;5:8021 Authors: García-Vilas JA, Quesada AR, Medina MA Abstract Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the potential of damnacanthal as a natural antitumor compound. The direct effect of damnacanthal on c-Met wa... περισσότερα »
speech and language; +27 new citations
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *speech and language* These pubmed results were generated on 2016/02/18 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Speech via xlomafota13 on Inoreader http://ift.tt/1mJAONf via IFTTT
Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules.
Related Articles *Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules.* Histol Histopathol. 2016 Feb 16;:11736 Authors: Trovato MC, Ruggeri RM, Scardigno M, Sturniolo G, Vita R, Vitarelli E, Arena G, Gambadoro O, Sturniolo G, Trimarchi F, Benvenga S, Bourdon JC, Cavallari V Abstract BACKGROUND: P53 isoforms originate from the alternative initiation of P53 gene translation through usage of an internal promoter located in intron 4. All P53 isoforms are spliced in intron 9 and may modulate cell proliferation and cell... περισσότερα »
Anaplastic thyroid carcinoma: Failure of conventional therapy but hope of targeted therapy.
Related Articles *Anaplastic thyroid carcinoma: Failure of conventional therapy but hope of targeted therapy.* Head Neck. 2016 Feb 16; Authors: Lennon P, Deady S, Healy ML, Toner M, Kinsella J, Timon CI, O'Neill JP Abstract BACKGROUND: Anaplastic thyroid cancer has a median survival between 1.2 and 10 months. The purpose of our study was to evaluate the outcomes of patients with anaplastic thyroid cancer in Ireland. METHODS: We carried out a retrospective analysis of the Irish National Cancer Database for patients with anaplastic thyroid cancer between 2000 and 2010. RESULTS: Of... περισσότερα »
Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules.
Related Articles *Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules.* Histol Histopathol. 2016 Feb 16;:11736 Authors: Trovato MC, Ruggeri RM, Scardigno M, Sturniolo G, Vita R, Vitarelli E, Arena G, Gambadoro O, Sturniolo G, Trimarchi F, Benvenga S, Bourdon JC, Cavallari V Abstract BACKGROUND: P53 isoforms originate from the alternative initiation of P53 gene translation through usage of an internal promoter located in intron 4. All P53 isoforms are spliced in intron 9 and may modulate cell proliferation and cell... περισσότερα »
Well-differentiated thyroid cancer - are you overtreating your patients?
*Well-differentiated thyroid cancer - are you overtreating your patients?* Endokrynol Pol. 2016;67(1):60-6 Authors: Nixon IJ Abstract Over the last 50 years there has been a move towards more aggressive therapy for well-differentiated thyroid cancer. In recent times, however, international guidelines have shown some trend back towards a more conservative approach to treating low-risk patients. This review explores how the state of the art in well-differentiated thyroid cancer research has evolved in tandem with improvements in riskstratification. A focus on the surgical approach ... περισσότερα »
Intracochlear Position of Cochlear Implants Determined Using CT Scanning versus Fitting Levels: Higher Threshold Levels at Basal Turn
*Objectives:* In this study, the effects of the intracochlear position of cochlear implants on the clinical fitting levels were analyzed. *Design:* A total of 130 adult subjects who used a CII/HiRes 90K cochlear implant with a HiFocus 1/1J electrode were included in the study. The insertion angle and the distance to the modiolus of each electrode contact were determined using high-resolution CT scanning. The threshold levels (T-levels) and maximum comfort levels (M-levels) at 1 year of follow-up were determined. The degree of speech perception of the subjects was evaluated during ro... περισσότερα »
True fenestration of the anterior communicating artery diagnosed by magnetic resonance angiography.
*True fenestration of the anterior communicating artery diagnosed by magnetic resonance angiography.* Surg Radiol Anat. 2016 Feb 17; Authors: Uchino A, Saito N, Uehara T, Neki H, Kohyama S, Yamane F Abstract Variations of the anterior cerebral artery-anterior communicating artery (ACoA) complex are common. Most are duplicated or partially duplicated ACoAs that are confused with fenestration of the ACoA. We report here an extremely rare case of true fenestration of the ACoA diagnosed by magnetic resonance angiography. Tiny true fenestrations of the ACoA may be overlooked easily by... περισσότερα »
The classification of frontal sinus pneumatization patterns by CT-based volumetry.
*The classification of frontal sinus pneumatization patterns by CT-based volumetry.* Surg Radiol Anat. 2016 Feb 16; Authors: Yüksel Aslier NG, Karabay N, Zeybek G, Keskinoğlu P, Kiray A, Sütay S, Ecevit MC Abstract PURPOSE: We aimed to define the classification of frontal sinus pneumatization patterns according to three-dimensional volume measurements. METHODS: Datasets of 148 sides of 74 dry skulls were generated by the computerized tomography-based volumetry to measure frontal sinus volumes. The cutoff points for frontal sinus hypoplasia and hyperplasia were tested by ROC curve... περισσότερα »
Pyruvate improved insulin secretion status in a mitochondrial diabetes mellitus patient.
*Pyruvate improved insulin secretion status in a mitochondrial diabetes mellitus patient.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154293 Authors: Inoue T, Murakami N, Ayabe T, Oto Y, Nishino I, Goto YI, Koga Y, Sakuta R Abstract CONTEXT: Mitochondrial diabetes is a rare form of diabetes mellitus accounting for up to 1% of all diabetes. Pyruvate therapy has been reported to be a potential therapeutic choice for patients with mitochondrial diseases. CASE DESCRIPTION: Water-based sodium pyruvate solutions (0.5 g/kg, thrice/day) were administrated orally to a 32-year-old Japanese ... περισσότερα »
Low endogenous secretory RAGE levels are associated with inflammation and carotid atherosclerosis in pre-diabetes.
*Low endogenous secretory RAGE levels are associated with inflammation and carotid atherosclerosis in pre-diabetes.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154069 Authors: Di Pino A, Francesca U, Rose Maria Z, Agnese F, Di Mauro S, Piro S, Purrello F, Maria Rabuazzo A Abstract CONTEXT: Pre-diabetes is associated with atherosclerotic vascular damage. OBJECTIVE: We investigated the correlation of endogenous secretory receptor for advanced glycation end-products (esRAGE) and total soluble RAGE (sRAGE) and markers of inflammation, with early cardiovascular disease in subjects with ... περισσότερα »
Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis.
*Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20154062 Authors: Espinosa De Ycaza AE, Rizza RA, Sreekumaran Nair K, Jensen MD Abstract CONTEXT: DHEA and testosterone hormones are advertised as anti-aging, anti-obesity products. However, the evidence that these hormones have beneficial effects on adipose tissue metabolism is limited. OBJECTIVE: To determine the effect of DHEA and testosterone supplementation on systemic lipolysis during a mixed meal test (MMTT) and an intravenous glucose tolerance ... περισσότερα »
Vitamin D supplementation does not impact insulin resistance in black and white children.
*Vitamin D supplementation does not impact insulin resistance in black and white children.* J Clin Endocrinol Metab. 2016 Feb 17;:jc20153687 Authors: Ferira AJ, Laing EM, Hausman DB, Hall DB, McCabe GP, Martin BR, Hill Gallant KM, Warden SJ, Weaver CM, Peacock M, Lewis RD Abstract CONTEXT: Vitamin D supplementation trials with diabetes-related outcomes have been conducted almost exclusively in adults and provide equivocal findings. OBJECTIVE: To determine the dose-response of vitamin D supplementation on fasting glucose, insulin and a surrogate measure of insulin resistance in wh... περισσότερα »
CORRIGENDUM.
Related Articles *CORRIGENDUM.* J Clin Endocrinol Metab. 2016 Feb 16;:jc20161043 Authors: PMID: 26881971 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1Q38EZq via IFTTT
upper respiratory tract infection; +77 new citations
77 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/02/18 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9J2G via IFTTT
This Month in Radiology.
*This Month in Radiology.* Radiology. 2016 Mar;278(3):3A-4A Authors: PMID: 26885744 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1R9Cnis via IFTTT
Image Noise Reduction Algorithm for Digital Subtraction Angiography: Clinical Results.
*Image Noise Reduction Algorithm for Digital Subtraction Angiography: Clinical Results.* Radiology. 2016 Mar;278(3):962 Authors: Söderman M, Holmin S, Andersson T, Palmgren C, Babić D, Hoornaert B PMID: 26885743 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9LaZ via IFTTT
Effect of Change in Portal Venous Blood Flow Rates on the Performance of a 2.45-GHz Microwave Ablation Device.
*Effect of Change in Portal Venous Blood Flow Rates on the Performance of a 2.45-GHz Microwave Ablation Device.* Radiology. 2016 Mar;278(3):962 Authors: Dodd GD, Kreidler SM, Lanctot AC, Glueck DH PMID: 26885742 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9IvA via IFTTT
Radiology Transitions in the Lion City.
*Radiology Transitions in the Lion City.* Radiology. 2016 Mar;278(3):961-962 Authors: Lim CC, Pua U PMID: 26885741 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9KDU via IFTTT
Potential Solution for the Age-Old Problem of CT Overuse in Emergency Departments?
*Potential Solution for the Age-Old Problem of CT Overuse in Emergency Departments?* Radiology. 2016 Mar;278(3):960-961 Authors: Chong C PMID: 26885740 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1R9CmLm via IFTTT
Role of Coronary CT Angiography in Patients with Stroke.
*Role of Coronary CT Angiography in Patients with Stroke.* Radiology. 2016 Mar;278(3):959-960 Authors: Kara K, Ozturk E, Sildiroglu O PMID: 26885739 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9F2V via IFTTT
Severe Bleeding after Percutaneous Transhepatic Drainage of the Biliary System.
*Severe Bleeding after Percutaneous Transhepatic Drainage of the Biliary System.* Radiology. 2016 Mar;278(3):957-959 Authors: Aung TH, Too CW, Kumar N, Damodharan K, Urlings TA, Patel A, Chan S, Toh L, Gogna A, Irani F, Lo R, Tan BS, Tay KH, Sum L PMID: 26885738 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1R9CmuR via IFTTT
James Lean Body Weight Formula Is Not Appropriate for Determining CT Contrast Media Dose in Patients with High Body Mass Index.
*James Lean Body Weight Formula Is Not Appropriate for Determining CT Contrast Media Dose in Patients with High Body Mass Index.* Radiology. 2016 Mar;278(3):956-957 Authors: Nyman U PMID: 26885737 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9Hbd via IFTTT
The Clinical Understaging of Recurrent Glottic Carcinoma after Radiation Failure
The Clinical Understaging of Recurrent Glottic Carcinoma after Radiation Failure: Background. Recurrent glottic squamous cell carcinomas following radiation therapy for early staged tumors are oftentime early staged tumors. Management of these early stage recurrences presents a dilemma for the head and neck surgeon. Difficulties in appropriate tumor mapping, preoperative analysis, and poor understanding of the virulent pathologic nature of the recurrence may impede surgical decision-making. Methods. This is a single surgeon case report, presenting a patient with rapid recurrence fol... περισσότερα »
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing: Vaccines and antibody therapeutics targeting staphylococcal surface molecules have failed to achieve clinical efficacy against MRSA infection. Here, Thomer et al. show that the R domain of prothrombin directs fibrinogen to the surface of S. aureus, which generates a protective coat for the pathogen, […]
Allergy and laryngeal disorders.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Allergy and laryngeal disorders.: Purpose of review: This article reviews recent literature on the topic of allergic laryngitis. There has been sustained interest over the past 15 years and epidemiological and experimental studies have led to a clearer description of the nature of the condition and its clinical expression. Recent findings: Recent studies have suggested […]
Evidence mounts for interbreeding bonanza in ancient human species
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Nature tallies the trysts among Neanderthals, humans and other relatives. Nature News doi: 10.1038/nature.2016.19394 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24bUlbf via IFTTT
The role of allergy immunotherapy in the treatment of asthma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
The role of allergy immunotherapy in the treatment of asthma.: Purpose of review: Asthma and allergic rhinitis are two of the most widespread chronic medical conditions. Asthma, a condition which encompasses chronic inflammation of the lower airway resulting in expiratory obstruction, may represent an end phase along the allergic disease spectrum ultimately stemming initially from […]
Changes in dermal matrix in the absence of Rac1 in keratinocytes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract Keratinocytes, in response to irritants, secrete pro-inflammatory mediators which recruit and activate immune and mesenchymal cells, including fibroblasts, to repair the skin. Fibroblasts respond by synthesising collagen and promoting the crosslinking extracellular matrix (ECM). We recently showed that the deletion of Rac1 in keratinocytes causes heightened inflammation due to aberrant crosstalk with immune cells. […]
Microvascular head and neck reconstruction after (chemo)radiation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices.: Purpose of review: This article critically analyzes the recent literature on microvascular head and neck reconstruction after (chemo)radiation [(C)RT], taking into consideration both the underlying pathogenetic mechanisms and their clinical consequences. Recent findings: Microvascular reconstruction has gradually become a mainstay in the management of head […]
Vaccination using melanoma cells treated with p19arf and interferon beta gene transfer in a mouse model: a novel combination for cancer immunotherapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract Previously, we combined p19Arf (Cdkn2a, tumor suppressor protein) and interferon beta (IFN-β, immunomodulatory cytokine) gene transfer in order to enhance cell death in a murine model of melanoma. Here, we present evidence of the immune response induced when B16 cells succumbing to death due to treatment with p19Arf and IFN-β are applied in vaccine […]
Ameloblastomas of the mandible and maxilla.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Ameloblastomas of the mandible and maxilla.: Purpose of review: This review focuses on issues in managing ameloblastomas of the mandible and maxilla. We will refer to current practice in the treatment of ameloblastomas based on the available evidence. Recent findings: Recent reviews have been trying to establish natural history, growth patterns and malignant potential. This […]
Association of XPF Levels and Genetic Polymorphism with Susceptibility to Ischemic Stroke
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Abstract The xeroderma pigmentosum group F (XPF) gene participates in the pathophysiological process of ischemic stroke, and XPF polymorphisms might be associated with ischemic stroke susceptibility. This study aimed to investigate XPF messenger RNA (mRNA) levels in peripheral blood mononuclear cells and protein levels in plasma and to analyze the 30028T/C polymorphism (rs1799801) in ischemic […]
Reasonable limits for transoral laser microsurgery in laryngeal cancer.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 35 δευτερόλεπτα
Reasonable limits for transoral laser microsurgery in laryngeal cancer.: Purpose of review: Transoral laser microsurgery (TLM) is widely acknowledged to offer several advantages in the treatment of early and selected intermediate-advanced laryngeal cancers. Nevertheless, a number of issues are still under debate. The purpose of this review is to discuss the reasonable limits for TLM […]
Esophageal Cancer with a Synchronous Multiple Carcinoid of the Duodenal Bulb.
*Esophageal Cancer with a Synchronous Multiple Carcinoid of the Duodenal Bulb.* Indian J Surg. 2015 Dec;77(6):543-4 Authors: Deng XF, Liu QX, Hou B, Min JX, Dai JG Abstract Carcinoid tumors of the duodenum are relatively rare. Although they were considered benign lesions, they are now classified malignant, occasionally with poor prognosis. We report a case of esophageal cancer with a synchronous multiple carcinoid of the duodenal bulb. An upper endoscopy visualized with esophageal scan disclosed a stenotic lesion in the lower esophagus and revealed multiple 4--5-mm-diameter masse... περισσότερα »
Diagnosis, treatment and prognosis in patients with liver metastases from follicular thyroid carcinoma (FTC).
*Diagnosis, treatment and prognosis in patients with liver metastases from follicular thyroid carcinoma (FTC).* Endokrynol Pol. 2016 Feb 17; Authors: Kałużna M, Gołąb M, Czepczyński R, Dworacki G, Bręborowicz D, Orłowski M, Katulska K, Klimowicz A, Gryczyńska M, Ruchała M, Ziemnicka K Abstract Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer (TC) and accounts for approximately 10 percent of all TC cases. Liver metastases are rare presentation in 0.5-1% of follicular thyroid cancers, usually occur in the setting of widely disseminated FTC disease... περισσότερα »
AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.
*AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.* Proc Natl Acad Sci U S A. 2016 Feb 16; Authors: Smith TL, Yuan Z, Cardó-Vila M, Sanchez Claros C, Adem A, Cui MH, Branch CA, Gelovani JG, Libutti SK, Sidman RL, Pasqualini R, Arap W Abstract Patients with inoperable or unresectable pancreatic neuroendocrine tumors (NETs) have limited treatment options. These rare human tumors often express somatostatin receptors (SSTRs) and thus are clinically responsive to certain relatively stable somatostatin analogs, such a... περισσότερα »
Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect.
*Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect.* Proc Natl Acad Sci U S A. 2016 Feb 16; Authors: Fassihi H, Sethi M, Fawcett H, Wing J, Chandler N, Mohammed S, Craythorne E, Morley AM, Lim R, Turner S, Henshaw T, Garrood I, Giunti P, Hedderly T, Abiona A, Naik H, Harrop G, McGibbon D, Jaspers NG, Botta E, Nardo T, Stefanini M, Young AR, Sarkany RP, Lehmann AR Abstract Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased susceptibility to UV radiation (UVR)-induced skin... περισσότερα »
Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China.
*Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China.* BMC Infect Dis. 2016;16(1):82 Authors: Yang J, Su S, Zhao H, Wang D, Wang J, Zhang F, Zhao Y Abstract BACKGROUND: Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer is rare in China. The purpose of our study was to investigate the prevalence and risk factors associated with cancer among HIV-infected inpatients in Beijing, and to investigate the mortality and risk factors among HIV-infected inpatients with cancer. METHO... περισσότερα »
Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.
*Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.* Oncotarget. 2016 Feb 12; Authors: Kanagal-Shamanna R, Luthra R, Yin CC, Patel KP, Takahashi K, Lu X, Lee J, Zhao C, Stingo F, Zuo Z, Routbort MJ, Singh RR, Fox P, Ravandi F, Garcia-Manero G, Medeiros LJ, Bueso-Ramos CE Abstract Isolated isochromosome 17q, i(17q), accounts for less than 1% of myeloid neoplasms that are commonly classified as myelodysplastic/myeloproliferative neoplasms, acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or myelo... περισσότερα »
An Unusual Cause of a Solitary Lung Cavity.
*An Unusual Cause of a Solitary Lung Cavity.* Conn Med. 2016 Jan;80(1):25-8 Authors: Yap V, Salerno E, Datta D Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology. Pulmonary involvement is common, but lung nodules in sarcoidosis are uncommon, and solitary nodules that cavitate are extremely rare. Nodular sarcoidosis is usually found in young, healthy, predominantly female individuals. These lesions need to be differentiated from multiple other conditions, including neoplasms and granulomatous infections. A thorough workup for other etiologies of cavitary ... περισσότερα »
Pediatric Chordomas: A Population-Based Clinical Outcome Study Involving 86 Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1973-2011).
Related Articles *Pediatric Chordomas: A Population-Based Clinical Outcome Study Involving 86 Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1973-2011).* Pediatr Neurosurg. 2016 Feb 17; Authors: Lau CS, Mahendraraj K, Ward A, Chamberlain RS Abstract BACKGROUND/AIMS: Primary chordomas, rare cancers arising from the notochord remnants, are extremely rare in the pediatric population. This study examined a large cohort of primary chordoma patients to determine factors impacting prognosis and survival. METHODS: Demographic and clinical data on 1,358 prim... περισσότερα »
Myxoid adrenal cortical adenoma in an infant: An unusual morphology.
Related Articles *Myxoid adrenal cortical adenoma in an infant: An unusual morphology.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1040 Authors: Chatterjee G, Dasgupta S, Bhattacharya K, Banerjee M, Ghosh R, Chatterjee U, Banerjee S Abstract Myxoid adrenal cortical neoplasms are rare. To the best of our knowledge, no such case has been reported in pediatric or infantile age group till now. Here we report a case of non-functional myxoid adrenocortical adenoma (ACA) in a 7-month-old girl, who presented with a large mass in the abdomen. Microscopically, the tumor was composed of alveolar... περισσότερα »
Mediastinal mixed germ cell tumor in an infertile male with Klinefelter syndrome:A case report and literature review.
Related Articles *Mediastinal mixed germ cell tumor in an infertile male with Klinefelter syndrome:A case report and literature review.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1034 Authors: Pradhan D, Kaman L, Dhillon J, Mohanty SK Abstract Klinefelter syndrome (KS) is a well-documented abnormality of the sex chromosome, with an incidence of 1 in 600 newborn males. It is characterized by a 47, XXY or a mosaic karyotype, hypergonadotrophic hypogonadism, infertility, reduced body hair, gynecomastia, and tall stature. Different neoplasms such as breast, testicular, and lymphoreticul... περισσότερα »
Genetic characteristics of the couple with non-syndromic sensorineural hearing loss and fertility guidance.
*Genetic characteristics of the couple with non-syndromic sensorineural hearing loss and fertility guidance.* Int J Clin Exp Med. 2015;8(11):21746-54 Authors: Liu RM, Liu HJ, Cong JL, Sun AL, Du JD, Sun CM Abstract PURPOSE: We aim to report a genetic testing and fertility guidance for the deaf through analyzing pedigree and molecular genetic characteristics of the couple who have non-syndromic sensorineural hearing loss (NSHL). METHODS: One of hospitalized congenial deaf couple and family members were included in this study. The wife was twin pregnant woman and her gestational age... περισσότερα »
Recessive mutations of TMC1 associated with moderate to severe hearing loss.
Related Articles *Recessive mutations of TMC1 associated with moderate to severe hearing loss.* Neurogenetics. 2016 Feb 16; Authors: Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S Abstract TMC1 encodes a protein required for the normal function of mechanically activated channels that enable sensory transduction in auditory and vestibular hair cells. TMC1 protein is localized at the tips of the hair cell stereocilia, the site of conventional mechanotransduction. In many populations, loss-of-function recessive mutations of TMC1 are associated with profound... περισσότερα »
Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy.
Related Articles *Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy.* Neural Plast. 2016;2016:7287180 Authors: Suh MW, Hyun J, Lyu AR, Kim DW, Park SJ, Choi JW, Hur GM, Park YH Abstract Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleostomy on the vestibular organs... περισσότερα »
Factors influencing the frequency of emergency department utilization by individuals with substance use disorders
Psychiatric Quarterly from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Vpttyl via IFTTT
Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice
British Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SB5tKF via IFTTT
A framework for training public health practitioners in crisis decision-making
Disaster Medicine and Public Health Preparedness from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Vptu5z via IFTTT
Play-based interventions improve physical function for people with adult-acquired brain injury: A systematic review and meta-analysis of randomised controlled trials
Clinical Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SB5tdS via IFTTT
Muscle strengthening activities and mortality with considerations by hearing sensitivity
10.3109/14992027.2016.1140233<br>Paul D. Loprinzi from #Audiology via xlomafota13 on Inoreader http://ift.tt/1ot230p via IFTTT
The role of allergy immunotherapy in the treatment of asthma.
Purpose of review: Asthma and allergic rhinitis are two of the most widespread chronic medical conditions. Asthma, a condition which encompasses chronic inflammation of the lower airway resulting in expiratory obstruction, may represent an end phase along the allergic disease spectrum ultimately stemming initially from nasal allergic rhinitis and bronchial hyper-reactivity. The purpose of this review was to evaluate the available published literature over the past 12 months regarding the role of allergy immunotherapy in the treatment of asthma. Recent findings: Recent clinical trial... περισσότερα »
Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.
*Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.* Dysphagia. 2016 Feb 17; Authors: Murray J, Doeltgen S, Miller M, Scholten I Abstract The benefit of water protocols for individuals with thin liquid aspiration remains controversial, with mixed findings from a small number of randomized controlled trials (RCTs). This study aimed to contribute to the evidence of the effectiveness of water protocols with a particular emphasis on health outcomes, especially hydration. An RCT was ... περισσότερα »
Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.
*Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.* Am J Gastroenterol. 2016 Feb;111(2):214-6 Authors: Richter JE Abstract The saga of esophageal dilation for patients with eosinophilic esophagitis and strictures reads like a historical novel. Currently, data from over 500 eosinophilic esophagitis (EoE) patients now convincingly prove that esophageal dilation is effective for prolonged relief and safe. It can easily be performed in the gastroenterologists community but follow the basic tenets of starting low with smal... περισσότερα »
Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.
[image: http:--production.springer.de-OnlineReso] Related Articles *Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.* Dig Dis Sci. 2015 Dec;60(12):3570-8 Authors: Suzuki N, Mihara H, Nishizono H, Tominaga M, Sugiyama T Abstract BACKGROUND: The reflux of pancreatic-duodenal fluids is implicated in the pathophysiology of proton-pump inhibitor-resistant gastroesophageal reflux disease (GERD). Protease-activated receptor-2 (PAR-2) is activated by proteases, the pancreatic enzyme, trypsin, and the activated P... περισσότερα »
Identification of behaviour change components in swallowing interventions for head and neck cancer patients: protocol for a systematic review.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Identification of behaviour change components in swallowing interventions for head and neck cancer patients: protocol for a systematic review.* Syst Rev. 2015;4:89 Authors: Govender R, Smith CH, Taylor SA, Grey D, Wardle J, Gardner B Abstract BACKGROUND: Dysphagia (difficulty in swallowing) is a predictable consequence of head and neck cancer and its treatment. Loss of the ability to eat and drink normally has a devastating impact on quality of life for survivors of this type of cancer. ... περισσότερα »
Extended Free Forearm Flap for Treatment of Temporomandibular Joint Pseudoankylosis.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Extended Free Forearm Flap for Treatment of Temporomandibular Joint Pseudoankylosis.* J Craniofac Surg. 2015 Jun;26(4):e358-9 Authors: Li M, Jiang HB, Tao ZJ, Wu YN Abstract Pseudoankylosis of temporomandibular joint (TMJ) is characterized by limited mouth opening and impaired mandibular mobility induced by pathologic factors outside the joint itself, usually leading to compromised speech, swallowing, and breath functions. Multiple surgical approaches or reconstructive procedures have been proposed to resolve the... περισσότερα »
Gastrointestinal food allergies.
Related Articles *Gastrointestinal food allergies.* Chem Immunol Allergy. 2015;101:171-80 Authors: Heine RG Abstract Gastrointestinal food allergies present during early childhood with a diverse range of symptoms. Cow's milk, soy and wheat are the three most common gastrointestinal food allergens. Several clinical syndromes have been described, including food protein-induced enteropathy, proctocolitis and enterocolitis. In contrast with immediate, IgE-mediated food allergies, the onset of gastrointestinal symptoms is delayed for at least 1-2 hours after ingestion in non-IgE-medi... περισσότερα »
Connections between client, clinician and context: Selected articles from the 2014 Speech Pathology Australia Conference.
Related Articles *Connections between client, clinician and context: Selected articles from the 2014 Speech Pathology Australia Conference.* Int J Speech Lang Pathol. 2015 Jun;17(3):197-8 Authors: Trembath D PMID: 25915181 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1KrSkRL via IFTTT
Developing clinical skills in paediatric dysphagia management using human patient simulation (HPS).
Related Articles *Developing clinical skills in paediatric dysphagia management using human patient simulation (HPS).* Int J Speech Lang Pathol. 2015 Jun;17(3):230-40 Authors: Ward EC, Hill AE, Nund RL, Rumbach AF, Walker-Smith K, Wright SE, Kelly K, Dodrill P Abstract PURPOSE: The use of simulated learning environments to develop clinical skills is gaining momentum in speech-language pathology training programs. The aim of the current study was to examine the benefits of adding Human Patient Simulation (HPS) into the university curriculum in the area of paediatric dysphagia. ME... περισσότερα »
Efficacy of exercises to rehabilitate dysphagia: A critique of the literature.
Related Articles *Efficacy of exercises to rehabilitate dysphagia: A critique of the literature.* Int J Speech Lang Pathol. 2015 Jun;17(3):222-9 Authors: Langmore SE, Pisegna JM Abstract PURPOSE: This review critiques the benefit of commonly used rehabilitative exercises for dysphagia. METHOD: Common goals of rehabilitation for dysphagia and principles of neuroplasticity are introduced as they apply to swallowing and non-swallowing exercises. A critique of published studies is offered regarding their evidence for showing benefit from the exercise. RESULT: One of five swallow exer... περισσότερα »
Nocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Nocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study.* Allergy. 2015 Jun;70(6):697-702 Authors: Schiöler L, Ruth M, Jõgi R, Gislason T, Storaas T, Janson C, Forsberg B, Sigsgaard T, Torén K, Hellgren J Abstract BACKGROUND: It has been suggested that gastroesophageal reflux disease (GERD) is a risk factor for developing rhinitis/rhinosinusitis, but data are lacking. This is a prospective 10-year follow-up study of a large multicenter cohort from Northern Europe, evaluating the relationship ... περισσότερα »
Mast cells or not? - CD117 positive cells in esophageal leiomyoma.
[image: http:--http://ift.tt/1Lgz4kT] Related Articles *Mast cells or not? - CD117 positive cells in esophageal leiomyoma.* Histol Histopathol. 2015 May;30(5):581-8 Authors: Ye JX, Liu Y, Qin Y, Ma XL, Zhong HH, Zhang Y, Shi XY Abstract The presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive c... περισσότερα »
Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.
[image: http:--production.springer.de-OnlineReso] Related Articles *Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.* Surg Endosc. 2015 Aug;29(8):2291-7 Authors: Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR, Frisella MM, Michael Brunt L, Matthews BD Abstract PURPOSE: The objective of this study was to evaluate the performance of acellular human dermis reinforcement during laparoscopic hiatal hernia repair. METHODS: A prospective non-randomized, single institution study enrolled patients undergoing laparoscopic hiatal hernia repair. Acellula... περισσότερα »
Laparoscopic repair of paraesophageal hernia with anterior gastropexy: a multicenter study.
[image: http:--production.springer.de-OnlineReso] Related Articles *Laparoscopic repair of paraesophageal hernia with anterior gastropexy: a multicenter study.* Surg Endosc. 2015 Jul;29(7):1856-61 Authors: Daigle CR, Funch-Jensen P, Calatayud D, Rask P, Jacobsen B, Grantcharov TP Abstract BACKGROUND: The approach to repair of paraesophageal hernias (PEHs) is controversial. Recent data suggest that mesh repair leads to recurrence rates similar to non-mesh approaches, while subjecting patients to mesh-associated complications. Routine fundoplication during PEH repair has been favo... περισσότερα »
[Deliberate release of the laryngeal adductor reflex via microdroplet impulses : Development of a device].
*[Deliberate release of the laryngeal adductor reflex via microdroplet impulses : Development of a device].* HNO. 2016 Feb 17; Authors: Ptok M, Schroeter S Abstract BACKGROUND: The laryngeal adductor reflex (LAR), a reflexive vocal fold closing mechanism, includes an early, probably di- or oligosynaptic ipsilateral LAR1- and a late ipsilateral and contralateral LAR2 polysynaptic component. In a clinical evaluation of dysphagia the LAR can be triggered by air pulses or tactile stimuli and typically assessed only qualitatively. METHODOLOGY: The development and construction of a dev... περισσότερα »
Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.
*Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.* Dysphagia. 2016 Feb 17; Authors: Murray J, Doeltgen S, Miller M, Scholten I Abstract The benefit of water protocols for individuals with thin liquid aspiration remains controversial, with mixed findings from a small number of randomized controlled trials (RCTs). This study aimed to contribute to the evidence of the effectiveness of water protocols with a particular emphasis on health outcomes, especially hydration. An RCT was ... περισσότερα »
Misdiagnosis of Extensive Maxillofacial Infection and Its Relationship with Periodontal Problems and Hyperglycemia.
*Misdiagnosis of Extensive Maxillofacial Infection and Its Relationship with Periodontal Problems and Hyperglycemia.* Case Rep Dent. 2016;2016:5960546 Authors: Statkievicz C, Faverani LP, Gomes-Ferreira PH, Ramalho-Ferreira G, Garcia-Junior IR Abstract Background. Complex dental infections can reach distant areas of the alveolar process, invading the secondary fascial spaces. Objectives. This case report aims to show a misdiagnosis of odontogenic infection and a great need for dentist in the hospital environment. Case Report. A male patient presented facial asymmetry and trismus,... περισσότερα »
Foreign body ingestion in children.
*Foreign body ingestion in children.* Turk Pediatri Ars. 2015 Dec;50(4):234-40 Authors: Dereci S, Koca T, Serdaroğlu F, Akçam M Abstract AIM: Foreign bodies ingested by the oral route enter into the gastrointestinal tract and are considered a significant health problem in the childhood. In this study, we evaluated the pediatric patients who presented to our hospital with the complaint of ingestion of foreign body. MATERIAL AND METHODS: The hospital records of all children who presented to our clinic because of ingestion of foreign body between January 2008 and January 2015 were ex... περισσότερα »
Laparoscopic Hiatal Hernia Repair in 221 Patients: Outcomes and Experience.
*Laparoscopic Hiatal Hernia Repair in 221 Patients: Outcomes and Experience.* JSLS. 2016 Jan-Mar;20(1) Authors: Chang CG, Thackeray L Abstract BACKGROUND AND OBJECTIVES: Hiatal hernia is a common condition often associated with symptomatic gastroesophageal reflux disease (GERD). The objectives of this study were to examine the efficacy and safety of laparoscopic hiatal hernia repair (LHHR) with biologic mesh to reduce and/or alleviate GERD symptoms and associated hiatal hernia recurrence. METHODS: We retrospectively reviewed consecutive LHHR procedures with biologic mesh performe... περισσότερα »
CT features and pathologic characteristics of IgG4-related systemic disease of submandibular gland.
*CT features and pathologic characteristics of IgG4-related systemic disease of submandibular gland.* Int J Clin Exp Pathol. 2015;8(12):16111-6 Authors: Wang Z, Feng R, Chen Y, Duan M, Wang M, Jin Z, Rumboldt Z, Zhang Z Abstract The submandibular gland is one of the most frequently affected salivary gland in IgG4-related systemic disease, usually demonstrate homogeneous attenuation on CT imaging as reported, but without much pathological comparison of many cases. This article is to investigate and analyze the typical CT findings and pathologic characteristics of IgG4-related syste... περισσότερα »
Expression of EBV antibody EA-IgA, Rta-IgG and VCA-IgA and SA in serum and the implication of combined assay in nasopharyngeal carcinoma diagnosis.
*Expression of EBV antibody EA-IgA, Rta-IgG and VCA-IgA and SA in serum and the implication of combined assay in nasopharyngeal carcinoma diagnosis.* Int J Clin Exp Pathol. 2015;8(12):16104-10 Authors: Xia C, Zhu K, Zheng G Abstract Epstein-Barr virus (EBV) is an important non-invasive index for nasopharyngeal carcinoma. Serum sialic acid (SA) level was known to be related with tumor progression. Rta protein antibody IgG (Rta-IgG), early antigen antibody (EA-IgA) and viral capsid antibody (VCA-IgA) levels in serum can also be used to effectively monitor the progression of cancer. ... περισσότερα »
RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration.
*RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration.* Int J Clin Exp Pathol. 2015;8(12):16097-103 Authors: Liu ZH, Huo JL, Wu ZG, Sun Z, Bai F, Samartzis D, Gantenbein B, Fan SD, Wang HQ Abstract Apoptosis plays an important role in intervertebral disc degeneration (IDD). Overwhelming evidence indicates that RASSF7 is essential for cell growth and apoptosis. Recently, it has been noted that the JNK signaling can be negatively regulated by suppressing phosphorylated-MKK7 activation during pro-apoptosis. We aimed to investigate the RAS... περισσότερα »
Evaluation of the management of Hr-HPV+/PapTest- women: results at 1-year recall.
*Evaluation of the management of Hr-HPV+/PapTest- women: results at 1-year recall.* Int J Clin Exp Pathol. 2015;8(12):16089-96 Authors: Chiappetta C, Puggioni C, Lendaro E, Cacciotti J, Zaralli R, Migliore G, Bellardini P, Petrozza V, Della Rocca C, Di Cristofano C Abstract With cervical cancer screening the choice of 1-year as a period of follow-up in positive high-risk HPV women without cytological lesions is still under discussion. We evaluated the management of these women and the role of HPV genotyping test. We did a cervical cancer screening study of women aged 35-64 with p... περισσότερα »
A three gene-based risk score predicts prognosis of resected non-small-cell lung cancer.
*A three gene-based risk score predicts prognosis of resected non-small-cell lung cancer.* Int J Clin Exp Pathol. 2015;8(12):16081-8 Authors: Liu K, Chen HL, Gu MM, You QS Abstract BACKGROUND: To study the prognosis-predicting value of a risk score based on phosphorylated At (p-Akt), vascular endothelial growth factor (VEGF), and Nin one binding (NOB1) expression in patients with resected non-small-cell lung cancer (NSCLC). METHODS: A prospective cohort among 98 consecutive patients with resected NSCLC was conducted in 2009 to 2010. Immunohistochemistry was used in the detection ... περισσότερα »
High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia.
*High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia.* Int J Clin Exp Pathol. 2015;8(12):16073-80 Authors: Zhou LY, Yin JY, Tang Q, Zhai LL, Zhang TJ, Wang YX, Yang DQ, Qian J, Lin J, Deng ZQ Abstract The purpose of this study was to investigate the expression status of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time quantitative PCR (RQ-PCR) was performed to detect the status of DUSP5P1 expression in 89 patient... περισσότερα »
(99m)Tc-3P-RGD2 SPECT to monitor early response to bevacizumab therapy in patients with advanced non-small cell lung cancer.
*(99m)Tc-3P-RGD2 SPECT to monitor early response to bevacizumab therapy in patients with advanced non-small cell lung cancer.* Int J Clin Exp Pathol. 2015;8(12):16064-72 Authors: Chen B, Zhao G, Ma Q, Ji B, Ji T, Xin H, Gao S Abstract The present study assessed the predictive value of (99m)Tc-3(poly-(ethylene glycol), PEG) 4-arginine-glycine-aspartic ((99m)Tc-3P-RGD2) single photon emission computed tomography (SPECT) for the early identification of response to antiangiogenic treatment with bevacizumab in patients with advanced non-small cell lung cancer (NSCLC). Patients with adv... περισσότερα »
Genetic polymorphisms of C-reactive protein increase susceptibility to HBV-related hepatocellular carcinoma in a Guangxi male population.
*Genetic polymorphisms of C-reactive protein increase susceptibility to HBV-related hepatocellular carcinoma in a Guangxi male population.* Int J Clin Exp Pathol. 2015;8(12):16055-63 Authors: Lao X, Ren S, Lu Y, Yang D, Qin X, Li S Abstract C-reactive protein (CRP) is a biomarker of inflammation and the production has been shown to be influenced by genetic variation in CRP gene. HBV-related hepatocellular carcinoma (HCC) is a typical inflammation-related disease occurs mainly in men. The present study was designed to investigate the association between CRP polymorphisms and HBV-r... περισσότερα »
Latent transforming growth factor-beta binding protein-1 in circulating plasma as a novel biomarker for early detection of hepatocellular carcinoma.
*Latent transforming growth factor-beta binding protein-1 in circulating plasma as a novel biomarker for early detection of hepatocellular carcinoma.* Int J Clin Exp Pathol. 2015;8(12):16046-54 Authors: Cao B, Yang L, Rong W, Feng L, Han N, Zhang K, Cheng S, Wu J, Xiao T, Gao Y Abstract This study aimed to assess the diagnostic value of the latent transforming growth factor-beta binding protein-1 (LTBP-1) in distinguishing hepatocellular carcinoma (HCC) from patients with hepatitis or liver cirrhosis. The protein levels of LTBP-1 or AFP in circulating plasma were measured by enz... περισσότερα »
Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1.
*Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1.* Int J Clin Exp Pathol. 2015;8(12):16036-45 Authors: Wang C, Lai Q, Zhang S, Hu J Abstract Polymorphisms of DNA repair enzymes which may influence their repair efficiency lead to diseases, for example, senile cataract. In this study, we aimed to analyze the association of single nucleotide polymorphisms in AP endonuclease-1 (APE1), 8-oxoguanine glycosylase-1 (OGG1) and X-ray repair cross-complementing-1 (XRCC1) genes with the risk of age-related cataract in a Chinese population. Genotyping was carried out by the ... περισσότερα »
Expression of PI3Kp110α and PI3Kp110β in the colorectal conventional adenoma, serrated lesions and adenoma with canceration and their significance.
*Expression of PI3Kp110α and PI3Kp110β in the colorectal conventional adenoma, serrated lesions and adenoma with canceration and their significance.* Int J Clin Exp Pathol. 2015;8(12):16026-35 Authors: Wu S, Li T, Mu Q, Li Y, Gao X, He S, Sun C Abstract AIMS: To evaluate the expression and clinical significance of PI3Kp110α and PI3Kp110β in colorectal conventional adenoma, serrated lesions and adenoma with canceration. METHODS AND RESULTS: Immunohistochemistry and Western blot analysis were conducted to detect the expression of p110α and p110β in normal colorectal tissues, conven... περισσότερα »
Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.
*Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.* Int J Clin Exp Pathol. 2015;8(12):16020-5 Authors: Wang X, Zhang Y, Huang L, Zhang J, Pan F, Li B, Yan Y, Jia B, Liu H, Li S, Zheng W Abstract Circular RNA (circRNA) is a type of RNAs which, unlike the better known linear RNA, forms a covalently closed continuous loop. They have emerged recently as a new player in governing fundamental biological processes. However it remains elusive about the correlation of hsa_circ_001988 abundance with colorectal cancer. To investigate the circular R... περισσότερα »
Circulating miR-122-5p as a potential novel biomarker for diagnosis of acute myocardial infarction.
*Circulating miR-122-5p as a potential novel biomarker for diagnosis of acute myocardial infarction.* Int J Clin Exp Pathol. 2015;8(12):16014-9 Authors: Yao XL, Lu XL, Yan CY, Wan QL, Cheng GC, Li YM Abstract BACKGROUND: MicroRNAs (miRNAs) play key roles in cardiac development, and the expression of miRNAs is altered in the diseased heart. The aim of this study was to explore the value of circulating microRNA-122-5p (miR-122-5p) as a potential biomarker for acute myocardial infarction (AMI). METHODS: Plasma samples from 50 patients with AMI and 39 healthy adults (non-AMI controls)... περισσότερα »
Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer.
*Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer.* Int J Clin Exp Pathol. 2015;8(12):16007-13 Authors: He J, Li J, Feng W, Chen L, Yang K Abstract Interferon-induced transmembrane protein 1 (IFITM1) has recently been implicated in tumorigenesis. However, the prognostic value of IFITM1 in colorectal cancer remains unknown. The present study aimed to examine the expression and prognostic significance of IFITM1 in human colorectal cancer. IFITM1 expression was analyzed in 144 archived, paraffin-embedded colorectal cancer tissues and corresponding ... περισσότερα »
Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.
*Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.* Int J Clin Exp Pathol. 2015;8(12):16000-6 Authors: Saadah OI, Al-Harthi SE, Al-Mughales JA, Bin-Taleb YY, Baeshen RS Abstract Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and Crohn's disease (CD) and to correlate the level with the disease progression. In this cross sectional prospective study, we enroll... περισσότερα »
Effect of immobilization stress on the appetite and stomach ghrelin expression in maternal mice.
*Effect of immobilization stress on the appetite and stomach ghrelin expression in maternal mice.* Int J Clin Exp Pathol. 2015;8(12):15993-9 Authors: Li B, Xu Y, Pan D, Xiao Q, Gao Q, Chen X, Peng X, Du Y, Gao P Abstract Maternal stress exerts long-lasting postnatal growth on offspring, which persist into adulthood. However, the effect of maternal stress on appetizing system has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight and food intake. Immunohistochemistry showed an increase in stomach ... περισσότερα »
Effect of bone marrow mesenchymal stem cells transplantation on the serum and liver HMGB1 expression in rats with acute liver failure.
*Effect of bone marrow mesenchymal stem cells transplantation on the serum and liver HMGB1 expression in rats with acute liver failure.* Int J Clin Exp Pathol. 2015;8(12):15985-92 Authors: Zheng S, Yang J, Tang Y, Yang J, Shao Q, Guo L, Liu Q Abstract OBJECTIVE: This study aimed to investigate the effect of bone marrow mesenchymal stem cells (BMSCs) transplantation on the expression of high mobility group box 1 protein (HMGB1) in the serum and liver of rats with acute liver failure (ALF). METHODS: Healthy male SD rats were randomly divided into control group, ALF group and BMSCs g... περισσότερα »
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients: Abstract ObjectiveA study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. Material and methodsA prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine... περισσότερα »
Correction
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
The paper Nikesitch, N. & Ling, S. C. 2015. Molecular mechanisms in multiple myeloma drug resistance. J Clin Pathol. Published in November 2015 has been updated to reflect the change in name of Western Sydney University. from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1SB1PAx via IFTTT
Clinical and laboratory characteristics of acute myeloid leukaemia (AML) at relapse and the risk of acute incapacitation
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
There is limited published data on the mode of relapse presentation in acute myeloid leukaemia (AML) and the efficacy of routine outpatient monitoring in detecting relapse. In diffuse large B cell lymphoma, studies looking at postremission surveillance imaging found that the majority of relapses were detected at patient self-presentation;1 however, there is no similar data available for AML. Such information would be of relevance to all patients in occupations requiring medical checks for public safety reasons, such as pilots and public transport drivers, where the risk of acute i... περισσότερα »
Biopsy interpretation of soft tissue tumours, second edition
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
This book is the 2nd edition of soft tissue tumours from the illustrious Biopsy Interpretation series. As I am not acquainted with the first edition, this review will be based entirely on this iteration of the book. I would like to start by saying that this book truly emerges like a 'good deed in a bad world'. This skilfully crafted and aesthetically pleasing book is written in a clear, succinct and unambiguous manner and covers a prodigious range of soft tissue tumours. The book opens with an instructive chapter on handling, reporting and grading soft tissue tumours. The remainin... περισσότερα »
Role of immunohistochemistry in the era of genetic testing in MYC-positive aggressive B-cell lymphomas: a study of 209 cases
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aims *MYC* rearrangements with or without *BCL2* rearrangements have been shown to be associated with poor prognosis and inferior survival in diffuse large B-cell lymphomas (DLBCL). Most of these cases are still diagnosed by fluorescent in situ hybridisation (FISH) testing, which is expensive, requires expertise and is not routinely available in all laboratories. Immunohistochemistry (IHC) is widely available and has the potential to be used as a screening test to identify cases with increased protein expression and select cases that require confirmatory testing. We correlated t... περισσότερα »
Quality assessment and preservation of RNA from biobank tissue specimens: a systematic review
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
It is well recognised that genomic, proteomic and biomarker studies require properly annotated and well-characterised biospecimens. Consequently, this necessitates biobanks to collect, store and distribute biospecimens under stringent quality control and assurance measures. However, despite this realisation, there remains a lack of standardisation in quality management among biobanks and consensus as to which quality indicators provide the optimal molecular diagnostic performance tools and information for biospecimens. In an attempt to identify key factors that predict tissue spec... περισσότερα »
National survey of B1 and B2 reporting of breast needle core biopsies
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aim This survey investigated the variation in the use of the breast core biopsy categories B1 normal and B2 benign. Method A survey with case scenarios was circulated to 701 breast pathologists in the UK. Results The response rate was 40%. If there was concordance between the radiological and histological findings, then there was a clear consensus on the appropriate B category. However, if there was discordance between the radiological and histological findings, then frequently there was poor agreement on the appropriate category. Analysis of these cases and supplementary que... περισσότερα »
Outcome of a new patient pathway for managing B3 breast lesions by vacuum-assisted biopsy: time to change current UK practice?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aims B3 lesions of the breast represent a difficult management dilemma. The umbrella term 'B3' incorporates lesions with little associated malignancy risk as well as lesions with significant risk of concurrent neoplasia. Diagnosis of B3 lesions in screening populations is largely made on needle core biopsy, which provides little tissue to adequately diagnose pathologically diverse lesions. The advent of vacuum-assisted biopsy (VAB) provides the multidisciplinary team with a more representative pathology sample to direct management. Methods In this unit, in 2009, a pathway to gu... περισσότερα »
The importance of tissue handling of surgically removed breast cancer for an accurate assessment of the Ki-67 index
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aim Insufficient attention for the Ki-67 immunohistochemistry has been given to the importance of tissue handling for surgical breast cancer specimens. We sought to investigate the effect of fixation status on the Ki-67. Methods We examined the effect of fixative, time to and duration of fixation using surgical specimens, and finally, compared the paired Ki-67 index in the tumour between core needle and surgical specimen. Results The Ki-67 was significantly higher when 10% neutral buffered formalin was used (p=0.0276). Insufficient fixation caused a drastic reduction in the Ki... περισσότερα »
Tissue factor is unregulated in microvascular endothelial cells of patients with heart failure
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aims Several lines of evidence point to hypercoagulability as an important factor for heart failure (HF) pathogenesis. Methods We hypothesised that endothelial tissue factor (TF) expression reflects altered tissue haemostasis which is related to the severity of HF. Accordingly, we investigated TF expression in the biopsies of 60 patients with HF and 22 without HF. In addition, we assessed the relationship between endothelial TF expression and clinical markers of HF severity. Results The control subjects without HF presented absent or weak TF expression in few microvessels, whi... περισσότερα »
Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Background Oxidative stress may play pathogenic roles in the mechanisms underlying chronic hepatitis C (CHC). The impact of excessive oxidative stress and iron dysregulation on the development of hepatocellular carcinoma (HCC) after interferon therapy has not been established. Methods We investigated the impact of oxidative stress and iron deposition on HCC development after therapy with pegylated interferon (PegIFN)+ribavirin in CHC patients. Systemic and intracellular iron homeostasis was evaluated in liver tissues, peripheral blood mononuclear cells and sera. Results Of 203... περισσότερα »
Correlation between DPYD gene variation and KRAS wild type status in colorectal cancer
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aims Failure and side effects of combined cytotoxic therapy are challenges in the treatment of metastatic colorectal cancer (CRC). *DPYD* gene variations can potentially predict toxicity to 5-fluorouracil (FU)-based therapy and *KRAS*-, *NRAS*-, *BRAF*-, *PIK3CA*-wild type status is a known prerequisite for epidermal growth factor receptor (EGFR) inhibitor therapy. This study was performed to search for a possible link between these therapeutic markers. Methods The *DPYD* gene variations c.496A>G, c.1679T>G, c.2846A>T and *KRAS/NRAS/BRAF/PIK3CA* mutational status were determine... περισσότερα »
AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Aims To clarify the clinical implications and functional role of the alanine-glyoxylate aminotransferase 2-like 1 (AGXT2L1) gene in hepatocellular carcinoma (HCC). Methods and results We confirmed that AGXT2L1 was down-regulated in liver cancer samples by immunohistochemical (IHC) staining. We also demonstrated that this down-regulation was associated with several clinicopathological features such as alpha fetoprotein (AFP) serum level and T stage. Furthermore, we showed with Kaplan-Meier analysis that expression of AGXT2L1 in tumour samples was significantly correlated with pa... περισσότερα »
Movement control during aspiration with different injection systems via video monitoring—an in vitro model
Movement control during aspiration with different injection systems via video monitoring—an in vitro model: Abstract ObjectivesThe aim of the present study was an evaluation of movement during double aspiration by different manual syringes and one computer-controlled local anesthesia delivery system (C-CLAD)*.* Materials and methodsWith five different devices (two disposable syringes (2, 5 ml), two aspirating syringes (active, passive), one C-CLAD), simulation of double aspiration in a phantom model was conducted. Two experienced and two inexperienced test persons carried out... περισσότερα »
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing: Vaccines and antibody therapeutics targeting staphylococcal surface molecules have failed to achieve clinical efficacy against MRSA infection. Here, Thomer et al. show that the R domain of prothrombin directs fibrinogen to the surface of *S. aureus*, which generates a protective coat for the pathogen, inhibiting phagocytosis by immune cells. The use of R-specific antibodies allows for immune cell recognition and protects mice against lethal bloodstream infections by broad spectrum MRSA isolat... περισσότερα »
The role of allergy immunotherapy in the treatment of asthma.
The role of allergy immunotherapy in the treatment of asthma.: Purpose of review: Asthma and allergic rhinitis are two of the most widespread chronic medical conditions. Asthma, a condition which encompasses chronic inflammation of the lower airway resulting in expiratory obstruction, may represent an end phase along the allergic disease spectrum ultimately stemming initially from nasal allergic rhinitis and bronchial hyper-reactivity. The purpose of this review was to evaluate the available published literature over the past 12 months regarding the role of allergy immunotherapy in ... περισσότερα »
Allergy and laryngeal disorders.
Allergy and laryngeal disorders.: Purpose of review: This article reviews recent literature on the topic of allergic laryngitis. There has been sustained interest over the past 15 years and epidemiological and experimental studies have led to a clearer description of the nature of the condition and its clinical expression. Recent findings: Recent studies have suggested an epidemiological association between the presence of allergy and concurrent laryngeal symptoms and objective signs. Both population-based studies and smaller investigations have shown a significant relationship betw... περισσότερα »
Microvascular head and neck reconstruction after (chemo)radiation
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices.: Purpose of review: This article critically analyzes the recent literature on microvascular head and neck reconstruction after (chemo)radiation [(C)RT], taking into consideration both the underlying pathogenetic mechanisms and their clinical consequences. Recent findings: Microvascular reconstruction has gradually become a mainstay in the management of head and neck cancer both in primary and salvage scenarios. However, limited data are available concerning the influence of previous radiotherapy... περισσότερα »
Ameloblastomas of the mandible and maxilla.
Ameloblastomas of the mandible and maxilla.: Purpose of review: This review focuses on issues in managing ameloblastomas of the mandible and maxilla. We will refer to current practice in the treatment of ameloblastomas based on the available evidence. Recent findings: Recent reviews have been trying to establish natural history, growth patterns and malignant potential. This provides the clinicians and the patients with useful prognostic information. Controversies in management of ameloblastomas in relation to the type, age and site exist. This paper aims to categorize these issues. ... περισσότερα »
Reasonable limits for transoral laser microsurgery in laryngeal cancer.
Reasonable limits for transoral laser microsurgery in laryngeal cancer.: Purpose of review: Transoral laser microsurgery (TLM) is widely acknowledged to offer several advantages in the treatment of early and selected intermediate-advanced laryngeal cancers. Nevertheless, a number of issues are still under debate. The purpose of this review is to discuss the reasonable limits for TLM in laryngeal cancer to highlight its most appropriate and reproducible indications, putting this therapeutic tool in the right perspective within a comprehensive frame of alternative treatment strategies... περισσότερα »
Early detection of oral cancers
Early detection of oral cancers: current status and future prospects.: Purpose of review: This article reviews the current literature and summarizes the latest developments in screening and early detection of oral cancers and looks at the future possibilities. Recent findings: Oral cancer is the best model for screening and prevention. The screening for oral cancer can be population based, opportunistic, or targeted. A long-term 15-year follow-up data of a randomized controlled study from a developing country setting indicated a sustained reduction in oral cancer mortality in high-r... περισσότερα »
The LittlEARS® Auditory Questionnaire for the assessment of auditory development in children
Production and evaluation of a Spanish version of via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Alba-Saida García Negro, Jose-Luis Padilla García, Manuel Sainz Quevedo Background and aimsTo adapt the LittlEARS® Auditory Questionnaire (LEAQ) into Spanish and evaluate the psychometric properties of the Spanish version of the questionnaire.MethodsThe LEAQ was translated into Spanish by a back-translation design. Following the Guidelines for Adapting Tests of the... περισσότερα »
Clinical practice guideline: tonsillitis II. Surgical management.
Clinical practice guideline: tonsillitis II. Surgical management.: Eur Arch Otorhinolaryngol. 2016 Feb 16; Authors: Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R Abstract In 2013, a total of 84,332 patients had undergone extracapsular tonsillectomies (TE) and 11,493 a tonsillotomy (TT) procedure in Germany. While the latter is increasingly performed, the number of the former is continually decreasing. However, a constant number of approximately 12,000 surgical procedures in terms of abscess-tonsillectomies or incision and drainage are annually performed in Germany to t... περισσότερα »
Pharmacological agents used for treatment and prevention in noise-induced hearing loss.
Pharmacological agents used for treatment and prevention in noise-induced hearing loss.: Eur Arch Otorhinolaryngol. 2016 Feb 16; Authors: Sakat MS, Kilic K, Bercin S Abstract Noise is a stress factor that causes auditory, psychological and physiological effects. The realization that sudden loud noises or chronic exposure to noise in social and working environments can cause hearing loss has led to increased interest in noise-induced hearing loss (NIHL). The best means of preventing primary damage is protection against noise. Since this protection is not always possible for various... περισσότερα »
Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Katarzyna B. Handing, Ivan G. Shabalin, Karol Szlachta, Karolina A. Majorek, Wladek Minor Serum albumin (SA) is the main transporter of drugs in mammalian blood plasma. Here, we report the first crystal structure of equine serum albumin (ESA) in complex with antihistamine drug cetirizine at a resolution of 2.1Å. Cetirizine is bound in two sites—a novel drug binding site (CBS1) and the fatty acid binding site 6 (CBS2). Both sites differ from those that have been proposed in multiple reports based on equi... περισσότερα »
Editorial Board/ Publication Information
Publication date: February 2016 *Source:*Molecular Immunology, Volume 70 from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1R9y86v via IFTTT
Statin-Associated Autoimmune Myopathy
Statins significantly reduce the incidence of cardiovascular disease, are generally safe, and have an acceptable side-effect profile. Indeed, a recent meta-analysis confirmed that mild musculoskeletal problems, such as myalgia, occur in approximately equal numbers of persons treated with statins… from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1osFkSa via IFTTT
Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.* J Dermatol. 2014 Oct;41(10):872-7 Authors: Nakamura Y, Fujisawa Y, Teramoto Y, Sato S, Yamada K, Sekine K, Fujimoto M, Otsuka F, Yamamoto A Abstract Subungual melanoma (SUM) is rare and represents approximately 2-3% and 20% of all cutaneous melanomas in Caucasians and Asians, respectively. Amputation has usually been performed for invasive SUM; however, not all invasive SUMs invade or attach to the distal phalanx. To investigate the ... περισσότερα »
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.* PLoS One. 2015;10(3):e0122662 Authors: Wadt KA, Aoude LG, Krogh L, Sunde L, Bojesen A, Grønskov K, Wartacz N, Ek J, Tolstrup-Andersen M, Klarskov-Andersen M, Borg Å, Heegaard S, Kiilgaard JF, Hansen TV, Klein K, Jönsson G, Drzewiecki KT, Dunø M, Hayward NK, Gerdes AM Abstract Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depen... περισσότερα »
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
High Ki67 expression is an independent good prognostic marker in colorectal cancer
Aims To correlate Ki67 expression with outcome in colorectal cancer (CRC). Methods Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters. Results Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p<0.0001) and nodal status (p=0.0315), but not with tumour grade (p=0.8639), histological tumour type (p=0.1542) or tumour localisation, and was... περισσότερα »
Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma
Aims The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary body melanoma. Methods The immunohistochemical expression of these markers was evaluated using 3,3'-diaminobenzidine tetrahydrochloride (DAB) and 3-amino-9-ethylcarbazole (AEC) chromogens on paraffin-embedded tissue samples from 40 patients who underwent enucleation in the period from 1985 through 2000. Thirty-one patients had adequa... περισσότερα »
Mechanisms and therapeutic effectiveness of lactobacilli
The gut microbiome is not a silent ecosystem but exerts several physiological and immunological functions. For many decades, lactobacilli have been used as an effective therapy for treatment of several pathological conditions displaying an overall positive safety profile. This review summarises the mechanisms and clinical evidence supporting therapeutic efficacy of lactobacilli. We searched Pubmed/Medline using the keyword '*Lactobacillus*'. Selected papers from 1950 to 2015 were chosen on the basis of their content. Relevant clinical and experimental articles using lactobacilli a... περισσότερα »
Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series
Aims Denosumab, a fully human monoclonal antibody directed against RANKL, has recently been introduced in the treatment strategy of giant cell tumour of bone (GCTB). Aim of this study was to investigate the phenotypical modifications induced by denosumab treatment in a series of 15 GCTB. Methods The tumours were characterised for histone 3.3 mutations, and studied immunohistochemically for the modifications of RANKL, RANK, SATB2 and RUNX2 expression, as well as of tumour proliferative activity and angiogenesis. Results Nine of 11 tumours investigated presented a histone 3.3 mut... περισσότερα »
Transfer of useful variability of high grain iron and zinc from Aegilops kotschyi into wheat through seed irradiation approach
10.3109/09553002.2016.1135263<br>Shailender Kumar Verma from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1WtoWeB via IFTTT
Movement control during aspiration with different injection systems via video monitoring—an in vitro model
Abstract Objectives The aim of the present study was an evaluation of movement during double aspiration by different manual syringes and one computer-controlled local anesthesia delivery system (C-CLAD)*.* Materials and methods With five different devices (two disposable syringes (2, 5 ml), two aspirating syringes (active, passive), one C-CLAD), simulation of double aspiration in a phantom model was conducted. Two experienced and two inexperienced test persons carried out double aspiration with the injection systems at the right and left phantom mandibles in three different incli... περισσότερα »
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients
Abstract Objective A study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. Material and methods A prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine resting, stimulated, and parotid salivary flow. Results The patients with RA had gre... περισσότερα »
The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio
Abstract Objectives The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. Materials and methods Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, 6 weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline... περισσότερα »
The Potential Significance of Concha Bullosa During Nasotracheal Intubation.
The authors experienced a case of severe epistaxis caused by accidental partial middle turbinectomy during nasotracheal intubation, which the patient had bilateral concha bullosa narrowing the nasal airway. Although anesthesiologist checked nasal airway through subjective symptoms and the size of both nostrils, they tend to overlook common anatomic variation, concha bullosa, and can injure turbinate structures. Therefore, preoperative computed tomography images should be carefully evaluated for the possibility of concha bullosa, which narrows nasal airway and induces the traumatic i... περισσότερα »
Movement control during aspiration with different injection systems via video monitoring—an in vitro model
Abstract Objectives The aim of the present study was an evaluation of movement during double aspiration by different manual syringes and one computer-controlled local anesthesia delivery system (C-CLAD)*.* Materials and methods With five different devices (two disposable syringes (2, 5 ml), two aspirating syringes (active, passive), one C-CLAD), simulation of double aspiration in a phantom model was conducted. Two experienced and two inexperienced test persons carried out double aspiration with the injection systems at the right and left phantom mandibles in three different incli... περισσότερα »
Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy.
The aim of this study was to measure the relative location between foramen ovale and internal carotid artery. The results can guide surgeons to avoid damaging internal carotid artery in cavernous sinus biopsy. One hundred twenty people (73 men and 47 women) were involved in this study anonymously. Five parameters of both sides were measured on 2 planes. This study provides data for safer cavernous sinus biopsy. (C) 2016 by Mutaz B. Habal, MD. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1RPSXGi via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Ni... περισσότερα »
Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients
Abstract Objective A study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. Material and methods A prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine resting, stimulated, and parotid salivary flow. Results The patients with RA had gre... περισσότερα »
Endoscopic Strip Craniectomy for Craniosynostosis: Do We Really Understand the Indications, Outcomes, and Risks?.
Endoscopic strip craniectomy with postoperative helmet therapy has been introduced as a means to correct various forms of craniosynostosis. Although some authors have deemed the procedure safe and effective, many questions remain regarding this promising yet developing approach. The authors discuss 4 cases where patients were inadequately treated with endoscopic strip craniectomy resulting in a recommendation of complete secondary open cranial vault reconstruction. In addition, the authors present the findings from an informal survey of craniofacial colleagues to highlight an import... περισσότερα »
The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio
Abstract Objectives The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. Materials and methods Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, 6 weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline... περισσότερα »
Central or axial atlantoaxial instability: Expanding understanding of craniovertebral junction
*Atul Goel* Journal of Craniovertebral Junction and Spine 2016 7(1):1-3 from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1QlQbJP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Inter- and Intra-Operator Reliability of Facial and Dental Measurements Using 3D-Stereophotogrammetry
Abstract Objectives The goal of this study was to assess the reproducibility of an innovative method for facial analysis with three-dimensional-stereophotogrammetry (3D-spg). Methods Twelve subjects with no obvious malocclusion participated in this study. For each of them, four photographs were acquired using the LifeVizTM, an absolute calibration 3D-spg system. The facial reconstructions were analyzed with the DermaPixTM image management software. Two different operators recorded distances between landmarks and each operator repeated the measurements after one week. The intra- ... περισσότερα »
Minimally invasive space shuttle laminotomy for degenerative lumbar spinal canal stenosis
*Shunji Asamoto, Jun Muto, Hiroyuki Jimbo* Journal of Craniovertebral Junction and Spine 2016 7(1):55-58 Study Design: Technical note. Objectives: To show microsurgical technique, considering the meticulous anatomy of the ligamentum flavum (LF). Background: Different methods are available for treating lumbar spinal canal stenosis (LSCS). A minimally invasive surgery, namely, space shuttle laminotomy, has recently been proposed. Here, we describe the surgical method for this novel technique. To conduct this surgery accurately, surgeons must have perfect knowledge of anatomy, especial... περισσότερα »
Color Correlations among Six Types of Permanent Anterior Teeth
Abstract Statement of Problem When multiple teeth are missing, the color for missing teeth should be estimated based on the color of remaining teeth. Purpose The purpose was to determine the strength of color correlations among six types of permanent anterior teeth. Methods Color of 12 anterior teeth was measured by Shade Vision System for 47 volunteers. The color coordinates in each type of teeth such as maxillary central incisor (MX1), lateral incisor (MX2), and canine (MX3), and mandibular central incisor (MD1), lateral incisor (MD2), and canine (MD3) were determined. Correl... περισσότερα »
Iatrogeny of Alzheimer's disease: A view point
*Manu Kothari, Lopa Mehta* Journal of Craniovertebral Junction and Spine 2016 7(1):4-6 from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1mIIXSe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Preferences of Lay Persons and Dental Professionals Regarding the Recurring Esthetic Dental Proportion
Abstract Background This study evaluated the preferences of dental professionals and lay persons with respect to the Recurring Esthetic Dental (RED) Proportion, an objective mathematical tool used in treatment planning the "apparent" widths of maxillary anterior teeth. Materials and Methods Stock dentofacial and facial images of a prototypical smiling male and female were digitally altered to demonstrate five different RED proportion relationships (0.62, 0.65, 0.70, 0.75, and 0.80). Four sets of the five altered images were presented to dental professionals and lay persons using ... περισσότερα »
Posterolateral instrumented fusion with and without transforaminal lumbar interbody fusion for the treatment of adult isthmic spondylolisthesis: A randomized clinical trial with 2-year follow-up
*Mohammad Reza Etemadifar, Abdollah Hadi, Mehran Feizi Masouleh* Journal of Craniovertebral Junction and Spine 2016 7(1):43-49 Background: Spondylolisthesis is a common cause of surgery in patients with lower back pain. Although posterolateral fusion and pedicle screw fixation are a relatively common treatment method for the treatment of spondylolisthesis, controversy exists about the necessity of adding interbody fusion to posterolateral fusion. The aim of our study was to assess the functional disability, pain, and complications in patients with spondylolisthesis treated by poster... περισσότερα »
Effect of Nanofiller Loading on Cure Efficiency and Potential Color Change of Model Composites
Abstract Objectives To evaluate the effect of nanofiller loading on cure efficiency and potential color change of experimental composites. Materials and Methods Four different polymeric materials were produced using the same organic matrix blend. To this matrix, different amounts of 0.05 μm fumed silica filler were added: no filler, 13, 52, and 65wt%. Fourier transform infrared spectroscopy was used to evaluate the degree of conversion (DC) for each composite using near-IR analysis, and spectrophotometry according to CIELab chromatic space was used to evaluate the color change.To... περισσότερα »
Ligamentum flavum hematomas: Why does it mostly occur in old Asian males? Interesting point of reported cases: Review and case report
*Bulent Ozdemir, Ayhan Kanat, Osman Ersegun Batcik, Hasan Gucer, Coskun Yolas* Journal of Craniovertebral Junction and Spine 2016 7(1):7-12 Hematoma of the ligamentum flavum (LF) is a rare cause of neural compression and sciatica. Currently, the etiology and epidemiological characteristics of ligamentum flavum hematoma (LFH) are unknown and epidemiological investigations using rewieving of reported cases have not been performed. We report the case of a 63-year-old man with a LFH compressing the spinal canal at the left L2-L3 level, rewieved relevant literature. In Medline research,... περισσότερα »
Shade of Resin-Based Luting Agents and Final Color of Porcelain Veneers
Abstract Objectives This study evaluated the influence of different shades of flowable resin composite used as luting agent on the final shade of porcelain veneers of different opacities over A2 and B1 simulated dental substrate. Materials and Methods One millimeter monolithic (enamel E1.0 or dentin D1.0) and bilayer (E0.5D0.5) porcelain discs shade A2 were paired with flowable resin composite disks (0.1 mm thick) of different shades (A1, A2, B1, white opaque – WO or IL – translucent), as veneer + luting agent (*n* = 10). The CIE *L***a***b** color coordinates were measured with ... περισσότερα »
An unusual cause of unilateral facial injuries caused by horseshoe headrest during prone positional craniovertebral junction surgery
*Chetna Shamshery, Rudrashish Haldar, Arun Srivastava, Ashutosh Kaushal, Shashi Srivastava, Prabhat K Singh* Journal of Craniovertebral Junction and Spine 2016 7(1):62-64 Pressure injuries are an accepted complication of prone positioning during the neurosurgical procedures. Horseshoe headrest are intended to reduce the incidence and severity of such injuries by allowing limited areas of contact between the skin of dependent areas of contact and the supporting surfaces. We report a case where a patient positioned prone over a horseshoe headrest developed inadvertent unilateral facia... περισσότερα »
Modern Concepts for Caries Tissue Removal
from #Dental via xlomafota13 on Inoreader http://ift.tt/24bzgxv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Evaluation the efficiency of cervical orthoses on cervical fracture: A review of literature
*Mohammad Taghi Karimi, Mostafa Kamali, Francis Fatoye* Journal of Craniovertebral Junction and Spine 2016 7(1):13-19 Background: Various methods have been used to stabilize the vertebra in cervical fractures, including the use of various orthoses and surgery. However, it is not cleared which type of orthosis is more suitable for the subjects with cervical fractures to best immobilize the vertebra and to decrease the associated side effects. Therefore, the aim of this study was to evaluate the efficiency of various orthoses based on the available literature. Materials and Methods: A... περισσότερα »
Comparative Performance of Mineral Trioxide Aggregate Versus Calcium Hydroxide as a Direct Pulp Capping Agent
Vital pulp therapy is the general concept involved in the "regenerative" restorative treatment of the reversibly injured dental pulp with the intention of maintaining its vitality in a restored, functioning tooth. While this procedure has been attempted with various materials and techniques over a period of several centuries, the advent of hard-setting calcium hydroxide materials in the late 1950s made the procedure of direct pulp capping a more routine and relatively predictable procedure. More recently, in the mid 1990s, a new type of water-based, "hydraulic-type," calcium sili... περισσότερα »
Factors affecting results of fluoroscopy-guided facet joint injection: Probable differences in the outcome of treatment between pure facet joint hypertrophy and concomitant diseases
*Akif Albayrak, Baris Ozkul, Mehmet Bulent Balioglu, Yunus Atici, Muhammet Zeki Gultekin, Merih Dilan Albayrak* Journal of Craniovertebral Junction and Spine 2016 7(1):38-42 Study Design: Retrospective cohort study. Purpose: Facet joints are considered a common source of chronic low-back pain. To determine whether pathogens related to the facet joint arthritis have any effect on treatment failure. Materials and Methods: Facet joint injection was applied to 94 patients treated at our hospital between 2011 and 2012 (mean age 59.5 years; 80 women and 14 men). For the purpose of analysi... περισσότερα »
Effect of Instrument Lubricants on the Surface Degree of Conversion and Crosslinking Density of Nanocomposites
Abstract Purpose The surface degree of conversion and crosslink density of composites should not be affected by the use of instrument lubricants in order to provide long-lasting tooth restorations. This study aimed to analyze the effect of instrument lubricants on the degree of conversion and crosslink density of nanocomposites. Materials and Methods Samples (*N* = 10) were fabricated according to the composites (Filtek Z350 XT, 3M ESPE, St. Paul, MN, USA; and IPS Empress Direct, Ivoclar Vivadent AG, Schaan, Liechtenstein and lubricants used (Adper Single Bond 2 and Scotchbond M... περισσότερα »
An Unusual Cause of a Solitary Lung Cavity.
*An Unusual Cause of a Solitary Lung Cavity.* Conn Med. 2016 Jan;80(1):25-8 Authors: Yap V, Salerno E, Datta D Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology. Pulmonary involvement is common, but lung nodules in sarcoidosis are uncommon, and solitary nodules that cavitate are extremely rare. Nodular sarcoidosis is usually found in young, healthy, predominantly female individuals. These lesions need to be differentiated from multiple other conditions, including neoplasms and granulomatous infections. A thorough workup for other etiologies of cavitary ... περισσότερα »
Editorial Board
Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/1OhJfph via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QLfa3j via IFTTT
Reducing health disparities: the role of sleep deficiency and sleep disorders
[image: 1-s2.0-S1389945715X00165-cov150h.gif] Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 Author(s): Aaron D. Laposky, Eve Van Cauter, Ana V. Diez-Roux Decrements in sleep health, including insufficient sleep duration, irregular timing of sleep, poor sleep quality, and sleep/circadian disorders, are widespread in modern society and are associated with an array of disease risks and outcomes, including those contributing to health disparities (eg, cardiovascular disease, obesity and diabetes, psychiatric illness, and cancer). Recent findings have uncovered racial... περισσότερα »
Parent knowledge of child sleep: a pilot study in a children's hospital cohort
[image: S13899457.gif] Publication date: Available online 17 February 2016 *Source:*Sleep Medicine Author(s): Philippa S. McDowall, Angela Campbell, Dawn Elder Objectives/BackgroundParent knowledge about child sleep may influence parent efforts to support healthy sleep in their children. The present study aimed to describe parent knowledge of child sleep in a hospital cohort, and potential correlates including barriers to children's bedtime, information seeking about child sleep, and demographics such as child age, parent education, and household income.Methods115 parents of children... περισσότερα »
Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movements recordings in healthy subjects: comparison with results based on polysomnography
[image: S13899457.gif] Publication date: Available online 17 February 2016 *Source:*Sleep Medicine Author(s): Alain Muzet, Sandra Werner, Gil Fuchs, Thomas Roth, Jay B. Saoud, Antoine Viola, Jean-Yves Schaffhauser, Rémy Luthringer ObjectiveThe objective of the study was to evaluate the reliability of a new methodology for assessing sleep architecture descriptors based on heart rate and body movement recordings.MethodsTwelve healthy male and female subjects between 18 and 40 years of age, without sleep disorders and not taking any drugs or medication that could affect sleep, were reco... περισσότερα »
Cognition, temperament and cerebral blood flow velocity in toddlers and preschool children with sleep disordered breathing or behavioral insomnia of childhood
[image: S13899457.gif] Publication date: Available online 17 February 2016 *Source:*Sleep Medicine Author(s): Rachael Spooner, Kurt Lushington, Hannah A.D. Keage, Sarah Blunden, J. Declan Kennedy, Mark Schembri, David Wabnitz, James Martin, Mark J. Kohler BackgroundCognitive decrements, problematic behaviours and increased cerebral blood flow velocities (CBFV) have been reported in children aged 3-7 years with sleep disordered breathing (SDB). Whether similar impairments in younger children or those with behavioral insomnia of childhood (BIC) is unclear. This study aimed to compare ... περισσότερα »
Rotigotine may improve sleep architecture in Parkinson's Disease: a double-blind, randomized, placebo-controlled polysomnographic study.
[image: S13899457.gif] Publication date: Available online 17 February 2016 *Source:*Sleep Medicine Author(s): Mariangela Pierantozzi, Fabio Placidi, Claudio Liguori, Maria Albanese, Paola Imbriani, Maria Grazia Marciani, Nicola Biagio Mercuri, Paolo Stanzione, Alessandro Stefani Background/ObjectivesGrowing evidence demonstrates that in Parkinson's Disease (PD) sleep disturbances are frequent and difficult to treat. Since the efficacy of rotigotine on sleep is corroborated by studies lacking polysomnography (PSG), this study would explore the possible rotigotine-mediated impact on P... περισσότερα »
A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder
[image: S13899457.gif] Publication date: Available online 16 February 2016 *Source:*Sleep Medicine Author(s): Shirley Xin Li, Siu Ping Lam, Jihui Zhang, Mandy Wai Man Yu, Joey Wing Yin Chan, Yaping Liu, Venny Kwai Ho Lam, Crover Kwok Wah Ho, Junying Zhou, Yun Kwok Wing BackgroundRapid eye movement sleep behavior disorder (RBD) is characterized by prominent dream-enacting behaviors, often resulting in sleep-related injuries.ObjectivesThis study aimed to prospectively examine the treatment response of people with RBD treated with clonazepam, by quantitatively delineating the character... περισσότερα »
Sleep disparity, race/ethnicity, and socioeconomic position
[image: 1-s2.0-S1389945715X00165-cov150h.gif] Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 Author(s): Michael A. Grandner, Natasha J. Williams, Kristen L. Knutson, Dorothy Roberts, Girardin Jean-Louis Sleep represents a set of biological functions necessary for the maintenance of life. Performing these functions, though, requires that an individual engage in behaviors, which are affected by social and environmental factors. Race/ethnicity and socioeconomic position represent categories of factors that likely play a role in the experience of sleep in the communi... περισσότερα »
Disparities and genetic risk factors in obstructive sleep apnea
[image: 1-s2.0-S1389945715X00165-cov150h.gif] Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 Author(s): Katherine A. Dudley, Sanjay R. Patel Obstructive sleep apnea (OSA) is an increasingly prevalent condition. A growing body of literature supports substantial racial disparities in the prevalence, risk factors, presentation, diagnosis, and treatment of this disease. Craniofacial structure among Asians appears to confer an elevated risk of OSA despite lower rates of obesity. Among African Americans, Native Americans, and Hispanics, OSA prevalence is increased, like... περισσότερα »
Viruses, Vol. 8, Pages 52: Infectious Salmon Anaemia Virus (ISAV) RNA Binding Protein Encoded by Segment 8 ORF2 and Its Interaction with ISAV and Intracellular Proteins
Infectious salmon anaemia virus (ISAV) is an orthomyxovirus infecting salmonid fish. The virus is adapted to low temperature and has a replication optimum between 10–15 °C. In this study the subcellular localization and protein interactions for the protein encoded by the largest open reading frame of gene segment 8 (s8ORF2) were investigated. In ISAV infected cells the s8ORF2 protein was found mainly in the cytosol but a minor fraction of cells expressed the protein in the nucleus as well. Green fluorescent protein-tagged s8ORF2 did not leak out of the cell when the plasma membran... περισσότερα »
Biopsy interpretation of soft tissue tumours, second edition
This book is the 2nd edition of soft tissue tumours from the illustrious Biopsy Interpretation series. As I am not acquainted with the first edition, this review will be based entirely on this iteration of the book. I would like to start by saying that this book truly emerges like a 'good deed in a bad world'. This skilfully crafted and aesthetically pleasing book is written in a clear, succinct and unambiguous manner and covers a prodigious range of soft tissue tumours. The book opens with an instructive chapter on handling, reporting and grading soft tissue tumours. The remainin... περισσότερα »
Correction
The paper Nikesitch, N. & Ling, S. C. 2015. Molecular mechanisms in multiple myeloma drug resistance. J Clin Pathol. Published in November 2015 has been updated to reflect the change in name of Western Sydney University. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SB1PAx via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QLf8bJ via IFTTT
Clinical and laboratory characteristics of acute myeloid leukaemia (AML) at relapse and the risk of acute incapacitation
There is limited published data on the mode of relapse presentation in acute myeloid leukaemia (AML) and the efficacy of routine outpatient monitoring in detecting relapse. In diffuse large B cell lymphoma, studies looking at postremission surveillance imaging found that the majority of relapses were detected at patient self-presentation;1 however, there is no similar data available for AML. Such information would be of relevance to all patients in occupations requiring medical checks for public safety reasons, such as pilots and public transport drivers, where the risk of acute i... περισσότερα »
Quality assessment and preservation of RNA from biobank tissue specimens: a systematic review
It is well recognised that genomic, proteomic and biomarker studies require properly annotated and well-characterised biospecimens. Consequently, this necessitates biobanks to collect, store and distribute biospecimens under stringent quality control and assurance measures. However, despite this realisation, there remains a lack of standardisation in quality management among biobanks and consensus as to which quality indicators provide the optimal molecular diagnostic performance tools and information for biospecimens. In an attempt to identify key factors that predict tissue spec... περισσότερα »
Role of immunohistochemistry in the era of genetic testing in MYC-positive aggressive B-cell lymphomas: a study of 209 cases
Aims *MYC* rearrangements with or without *BCL2* rearrangements have been shown to be associated with poor prognosis and inferior survival in diffuse large B-cell lymphomas (DLBCL). Most of these cases are still diagnosed by fluorescent in situ hybridisation (FISH) testing, which is expensive, requires expertise and is not routinely available in all laboratories. Immunohistochemistry (IHC) is widely available and has the potential to be used as a screening test to identify cases with increased protein expression and select cases that require confirmatory testing. We correlated th... περισσότερα »
National survey of B1 and B2 reporting of breast needle core biopsies
Aim This survey investigated the variation in the use of the breast core biopsy categories B1 normal and B2 benign. Method A survey with case scenarios was circulated to 701 breast pathologists in the UK. Results The response rate was 40%. If there was concordance between the radiological and histological findings, then there was a clear consensus on the appropriate B category. However, if there was discordance between the radiological and histological findings, then frequently there was poor agreement on the appropriate category. Analysis of these cases and supplementary ques... περισσότερα »
Outcome of a new patient pathway for managing B3 breast lesions by vacuum-assisted biopsy: time to change current UK practice?
Aims B3 lesions of the breast represent a difficult management dilemma. The umbrella term 'B3' incorporates lesions with little associated malignancy risk as well as lesions with significant risk of concurrent neoplasia. Diagnosis of B3 lesions in screening populations is largely made on needle core biopsy, which provides little tissue to adequately diagnose pathologically diverse lesions. The advent of vacuum-assisted biopsy (VAB) provides the multidisciplinary team with a more representative pathology sample to direct management. Methods In this unit, in 2009, a pathway to gui... περισσότερα »
Chemical and plant-based insect repellents: efficacy, safety, and toxicity
Wilderness & Environmental Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VptthZ via IFTTT
Early rehabilitation for severe acquired brain injury in intensive care unit: multicenter observational study
European Journal of Physical and Rehabilitation Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SB5uyg via IFTTT
Percutaneous Tracheostomy in post cervical spine fixation patients: Challenging the dogma
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VptthT via IFTTT
Prior cannabis use is associated with outcome after intracerebral hemorrhage
Cerebrovascular Diseases from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SAZdmd via IFTTT
Re: Contact isolation is a risk factor for venous thromboembolism in trauma patients.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/210tUpK via IFTTT
Issues regarding patient assessment scores that focus on acid base changes in fracture patients.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Qnsx9t via IFTTT
Hyperoxic resuscitation following hemorrhage: Good, harmless, or harmful?.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/210tUWY via IFTTT
The state of the union: Nationwide absence of uniform guidelines for the pre-hospital use of tourniquets to control extremity exsanguination.
Background: Following the Sandy Hook shootings and the resulting Hartford Consensus, as well as the recent Boston Marathon bombing, the need for a uniform, detailed, aggressive, pre-hospital extremity exsanguination control protocol became clear. We hypothesized that most states within the United States lack a detailed, uniform protocol. Methods: We performed a systematic, nationwide assessment of Emergency Medical Services (EMS) pre-hospital extremity exsanguination control protocols. An online search (updated 02/07/2015) identified state, region, or county-specific EMS protocols i... περισσότερα »
Re: Hyperoxic resuscitation following hemorrhage: good, harmless, or harmful?.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/210tUWW via IFTTT
Contemporary outcomes of lower extremity vascular repairs extending below the knee: A multicenter retrospective study.
Objectives: To determine the outcomes of vascular injury interventions extending below the knee. Methods: Vascular injury repairs extending below the knee from January 2008-December 2014 were collected from 6 American College of Surgeons Level I trauma centers. Demographics, management and outcomes were collected and analyzed. Results: A total of 194 vascular injuries were identified. The mean age was 33.7, with 88.1% male, and 71.1% suffering from blunt injury. Admission systolic blood pressure was from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QnsuKI via IFTTT
Creation of a decision aid for goal-setting after geriatric burns: A study from the prognostic assessment of life and limitations after trauma in the elderly [PALLIATE] consortium.
Objectives: We hypothesized that a decision-support aid to predict index admission mortality and discharge disposition for geriatric burns could be constructed using the well-accepted Baux score (age + total body surface area burned) in a geriatric-specific cohort. Methods: National Burn Repository version 8.0 (2002-2011) was queried for all subjects aged >=65 years. Baux scores were calculated and patients grouped into deciles. Three discharge outcomes (death, home, discharge to non-home setting) were measured per decile. A receiver operating characteristic analysis was used to det... περισσότερα »
CT abbreviated assessment of sarcopenia following trauma: The CAAST measurement predicts 6-month mortality in older adult trauma patients.
Background: Older adult trauma patients are at increased risk of poor outcome, both immediately after injury and beyond hospital discharge. Identifying patients early in the hospital stay who are at increased risk of death after discharge can be challenging. Methods: Retrospective analysis was performed using our trauma registry linked with the social security death index from 2010-2014. Age was categorized by 18-64 and >=65 years. We calculated mortality rates by age category then selected elderly patients with mechanism of injury being a fall for further analysis. CT Abbreviated A... περισσότερα »
Contact isolation is a risk factor for venous thromboembolism in trauma patients.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/210tU9s via IFTTT
Re: Issues regarding patient assessment scores that focus on acid base changes in fracture patients.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Qnsx9l via IFTTT
Not all prehospital time is equal: Influence of scene time on mortality.
Background: Trauma is time-sensitive and minimizing prehospital (PH) time is appealing. However, most studies have not linked increasing PH time with worse outcomes, as raw PH times are highly variable. It is unclear whether specific PH time patterns affect outcomes. Our objective was to evaluate the association of PH time interval distribution with mortality. Methods: Patients transported by EMS in the Pennsylvania trauma registry 2000-2013 with total prehospital time (TPT)>=20min were included. TPT was divided into three PH time intervals: response, scene, and transport time. The ... περισσότερα »
Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors.
*Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors.* Otolaryngol Head Neck Surg. 2016 Feb 16; Authors: Witt RL PMID: 26884366 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1QmAmlU via IFTTT
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy.
*Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy.* Otolaryngol Head Neck Surg. 2016 Feb 16; Authors: Birkeland AC, Rosko AJ, Issa MR, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME Abstract OBJECTIVES: The indications for neck dissection concurrent with salvage laryngectomy in the clinically N0 setting remain unclear. Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage... περισσότερα »
2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Ménière's Disease.
*2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Ménière's Disease.* Otolaryngol Head Neck Surg. 2016 Feb 16; Authors: Goebel JA Abstract Ménière's disease is a disorder of the inner ear that causes attacks of vertigo and hearing loss, tinnitus, aural fullness in the involved ear. Over the past 4 decades, the Equilibrium Committee of the AAO-HNS has issued guidelines for diagnostic criteria, with the latest version being published in 1995. These criteria were reviewed in 2015 by the Equilibrium Committee, and revisions were approved at th... περισσότερα »
Systematic Review on Surgical Outcomes and Hearing Preservation for Cochlear Implantation in Children and Adults.
*Systematic Review on Surgical Outcomes and Hearing Preservation for Cochlear Implantation in Children and Adults.* Otolaryngol Head Neck Surg. 2016 Feb 16; Authors: Bruijnzeel H, Draaisma K, van Grootel R, Stegeman I, Topsakal V, Grolman W Abstract OBJECTIVE: The mastoidectomy with facial recess approach (MFRA) is considered the reference standard for cochlear implantation. The suprameatal approach (SMA) was developed more recently and does not require mastoidectomy, which could influence postoperative outcomes. We aim to identify the optimal operative approach for cochlear impl... περισσότερα »
Implementation of a Pediatric Posttonsillectomy Pain Protocol in a Large Group Practice.
*Implementation of a Pediatric Posttonsillectomy Pain Protocol in a Large Group Practice.* Otolaryngol Head Neck Surg. 2016 Feb 16; Authors: Luk LJ, Mosen D, MacArthur CJ, Grosz AH Abstract OBJECTIVE: In response to the increased risk of respiratory failure and death after tonsillectomy related to codeine use, Kaiser Permanente Northwest restricted use of opioids in patients <7 years old via electronic health record (EHR). However, opioids could be prescribed at physician discretion by overriding the EHR. This study aims to examine protocol compliance in a large group practice us... περισσότερα »
An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery.
*An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery.* Odontology. 2016 Feb 17; Authors: Iwai T, Omura S, Honda K, Yamashita Y, Shibutani N, Fujita K, Takasu H, Murata S, Tohnai I Abstract Bimaxillary orthognathic surgery has been widely performed to achieve optimal functional and esthetic outcomes in patients with dentofacial deformity. Although Le Fort I osteotomy is generally performed before bilateral sagittal split osteotomy (BSSO) in the surgery, in several situations BSSO sho... περισσότερα »
Traumatic dental injury: a case review.
*Traumatic dental injury: a case review.* Minerva Stomatol. 2016 Feb 16; Authors: Gualniera P, Scurria S, Sapienza D, Asmundo A Abstract BACKGROUND: To retrospectively evaluate the incidence of traumatic dental injury and consequential dental impairment following road traffic accidents and to examine the factors that can affect the monetary value of compensation for bodily injury payable pursuant to current insurance regulations. METHOD: During the decade from 2004 to 2014, 7,233 persons involved in road traffic accidents in the province of Messina, eastern Sicily, were examined ... περισσότερα »
[Deliberate release of the laryngeal adductor reflex via microdroplet impulses : Development of a device].
*[Deliberate release of the laryngeal adductor reflex via microdroplet impulses : Development of a device].* HNO. 2016 Feb 17; Authors: Ptok M, Schroeter S Abstract BACKGROUND: The laryngeal adductor reflex (LAR), a reflexive vocal fold closing mechanism, includes an early, probably di- or oligosynaptic ipsilateral LAR1- and a late ipsilateral and contralateral LAR2 polysynaptic component. In a clinical evaluation of dysphagia the LAR can be triggered by air pulses or tactile stimuli and typically assessed only qualitatively. METHODOLOGY: The development and construction of a dev... περισσότερα »
Application experience of intraoperative neuromonitoring in thyroidectomy.
*Application experience of intraoperative neuromonitoring in thyroidectomy.* Int J Clin Exp Med. 2015;8(12):22359-64 Authors: Zheng H, Jiang L, Wang X, Hu J, Ning J, Wang D, Li B, Zheng G, Xu J Abstract OBJECTIVE: The aim of this study is to summarize the experience of intraoperative neuromonitoring system for monitoring and protection of recurrent laryngeal nerve during thyroid surgery. METHODS: There were 220 cases in this study, male 53, female 167, mean age 38.2 years old. 85 cases in the study had thyroid cancer, 19 cases had thyroid benign tumor, 90 cases had thyroid goiter, ... περισσότερα »
Propranolol treatment of subglottic hemangiomas: a review of the literature.
*Propranolol treatment of subglottic hemangiomas: a review of the literature.* Int J Clin Exp Med. 2015;8(11):19886-90 Authors: Wu L, Wu X, Xu X, Chen Z Abstract Subglottic hemangiomas (SGH), which are rare benign tumors of the airway, are potentially life-threatening conditions that may require intervention. Propranolol appears to be an effective treatment for these tumors and should therefore be a first-line treatment for SGH that require intervention. This review presents the clinical presentation and diagnosis of SGH and discusses current knowledge regarding the use of propra... περισσότερα »
Autofluorescence spectroscopy in the differentiation of laryngeal epithelial lesions - preliminary results.
Related Articles *Autofluorescence spectroscopy in the differentiation of laryngeal epithelial lesions - preliminary results.* Acta Otolaryngol. 2016 Feb 16;:1-5 Authors: Winiarski P, Szewczyk-Golec K, Orłowski P, Kałużna E, Wamka M, Mackiewicz-Nartowicz H, Sinkiewicz A, Fisz JJ Abstract Conclusions Autofluorescence spectroscopy may be a supporting tool for differential diagnosis of changes in laryngeal epithelium. Objectives Early detection and differential diagnosis of proliferative changes in the larynx are still a challenge for laryngologists. The aim of the study was to eva... περισσότερα »
The utility of [18F] fluorodeoxyglucose-positron emission tomography/computed tomography for detecting lung and esophagus multiple primary cancers involved in the larynx: Two case reports.
Related Articles *The utility of [18F] fluorodeoxyglucose-positron emission tomography/computed tomography for detecting lung and esophagus multiple primary cancers involved in the larynx: Two case reports.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1039 Authors: Wang Q, Chai L, Zhou S Abstract Multiple primary cancers involved in the larynx of differentiating synchronous multiple primary cancers from metastasis can often be very difficult, especially when they have the same histology. However, it is very important because the therapeutic approach is completely different. Clinical s... περισσότερα »
Osteosarcoma of larynx: A rare case report with review of literature.
Related Articles *Osteosarcoma of larynx: A rare case report with review of literature.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1038 Authors: Bahl A, George P, Bhattacharyya T, Ghoshal S, Bakshi J, Das A Abstract Laryngeal osteosarcoma is an extremely rare and aggressive malignancy. Only very few cases of primary laryngeal osteosarcomas are reported in literature, and all have a dismal prognosis. A 50-year-old male presented with recurrent hoarseness of voice and was evaluated and diagnosed as sarcoma larynx. Detailed histopathology report of laryngectomy specimen revealed presenc... περισσότερα »
Tracheal Involvement in Crohn Disease: the First Case in Korea.
Related Articles *Tracheal Involvement in Crohn Disease: the First Case in Korea.* Clin Endosc. 2016 Feb 16; Authors: Park S, Park J, Kim HK, Kim JY, Hur SC, Lee JH, Jung JW, Lee J Abstract Respiratory involvement in Crohn disease (CD) is rare condition with only about a dozen reported cases. We report the first case of CD with tracheal involvement in Korea. An 18-year-old woman with CD was hospitalized because of coughing, dyspnea, and fever sustained for 3 weeks. Because she had stridor in her neck, we performed computed tomography of the neck, which showed circumferential wall... περισσότερα »
Relationship of the Cricothyroid Space with Vocal Range in Female Singers.
Related Articles *Relationship of the Cricothyroid Space with Vocal Range in Female Singers.* J Voice. 2016 Feb 13; Authors: Pullon B Abstract OBJECTIVES: This study aims to investigate the relationship between the anterior cricothyroid (CT) space at rest with vocal range in female singers. Potential associations with and between voice categories, age, ethnicity, anthropometric indices, neck dimensions, laryngeal dimensions, vocal data along with habitual speaking fundamental frequency were also explored. STUDY DESIGN: This is a cohort study. METHODS: Laryngeal dimensions anterio... περισσότερα »
Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy.* Anticancer Res. 2015 Nov;35(11):6049-56 Authors: Han X, Pires L, Browne JD, Sullivan CA, Zhao W, Feng X Abstract BACKGROUND: Laryngeal muscles play an important role in breathing, sound production and trachea protection against food. Laryngeal dysfunctions during radiotherapy for head and neck cancers are common. In the present study, we aimed to investigate the early effect of radiation on the laryngeal muscles in vivo ... περισσότερα »
Reinke Edema: Watch For Vocal Fold Cysts.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Reinke Edema: Watch For Vocal Fold Cysts.* J Craniofac Surg. 2015 Jun;26(4):e338-9 Authors: Tüzüner A, Demirci S, Yavanoglu A, Kurkcuoglu M, Arslan N Abstract Reinke edema is one of the common cause of dysphonia middle-aged population, and severe thickening of vocal folds require surgical treatment. Smoking plays a major role on etiology. Vocal fold cysts are also benign lesions and vocal trauma blamed for acquired cysts. We would like to present 3 cases with vocal fold cyst related with Reinke edema. First case ... περισσότερα »
The behavioural treatment of muscle tension voice disorders: A systematic review.
Related Articles *The behavioural treatment of muscle tension voice disorders: A systematic review.* Int J Speech Lang Pathol. 2015 Jun;17(3):287-303 Authors: Eastwood C, Madill C, Mccabe P Abstract PURPOSE: A systematic review of behavioural intervention for the treatment of adults with muscle tension voice disorders (MTVD). METHOD: A search of 12 electronic databases and reference lists for studies published between the years 1990-2014 was conducted using the PRISMA guidelines. Inclusion and exclusion criteria included type of publication, participant characteristics, intervent... περισσότερα »
Gone but not forgotten: a case of respiratory distress.
Related Articles *Gone but not forgotten: a case of respiratory distress.* Clin Pediatr (Phila). 2015 Jun;54(7):697-9 Authors: Wing R, Manno M PMID: 25896724 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1PSO5vo via IFTTT
Intraoral pressures produced by thirteen semi-occluded vocal tract gestures.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Intraoral pressures produced by thirteen semi-occluded vocal tract gestures.* Logoped Phoniatr Vocol. 2015 Jul;40(2):86-92 Authors: Maxfield L, Titze I, Hunter E, Kapsner-Smith M Abstract The use of semi-occluded vocal tract (SOVT) exercises as habilitative and rehabilitative tools has grown substantially in the past two decades. As the use of these exercises has grown, so too has the number of variations of the phonatory gestures used to create oral semi-occlusions. While much of the research on SOVT exercises to this point... περισσότερα »
An estimation of the population incidence of adult unilateral vocal fold mobility impairment in England.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *An estimation of the population incidence of adult unilateral vocal fold mobility impairment in England.* Logoped Phoniatr Vocol. 2015 Jul;40(2):93-4 Authors: Nouraei SA, Middleton SE, Butler CR, Sandhu GS Abstract We estimate the population incidence of adult unilateral vocal fold mobility impairment at 5.13 per 100,000 per year. PMID: 24850272 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1ot2cRE via IFTTT
A classification system for airway compromise due to bilateral vocal fold mobility impairment.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *A classification system for airway compromise due to bilateral vocal fold mobility impairment.* Logoped Phoniatr Vocol. 2015 Jul;40(2):95-7 Authors: Nouraei SA, Sandhu GS Abstract We present a system for classification of bilateral vocal fold mobility impairment. Type 1 obstructions are caused by bilateral laryngeal denervation, most commonly due to bilateral recurrent laryngeal nerve palsy. Type 2 obstructions are caused by crico-arytenoid joint ankylosis. Type 3 obstructions are due to inter-arytenoid granulation tissue. T... περισσότερα »
A new multilayer reconstruction using nasal septal flap combined with fascia graft dural suturing for high-flow cerebrospinal fluid leak after endoscopic endonasal surgery.
*A new multilayer reconstruction using nasal septal flap combined with fascia graft dural suturing for high-flow cerebrospinal fluid leak after endoscopic endonasal surgery.* Neurosurg Rev. 2016 Feb 17; Authors: Horiguchi K, Nishioka H, Fukuhara N, Yamaguchi-Okada M, Yamada S Abstract This study aimed to evaluate the usefulness and reliability of a new endoscopic multilayer reconstruction using nasal septal flap (NSF) to prevent high-flow cerebrospinal fluid leak after endoscopic endonasal surgery. This study was a retrospective review on 97 patients who underwent multilayer reco... περισσότερα »
Extended Pneumocephalus after Drainage of Chronic Subdural Hematoma Associated with Intracranial Hypotension : Case Report with Pathophysiologic Consideration.
*Extended Pneumocephalus after Drainage of Chronic Subdural Hematoma Associated with Intracranial Hypotension : Case Report with Pathophysiologic Consideration.* J Korean Neurosurg Soc. 2016 Jan;59(1):69-74 Authors: Shin HS, Lee SH, Ko HC, Koh JS Abstract Chronic subdural hematoma (SDH) is a well-known disease entity and is traditionally managed with surgery. However, when associated with spontaneous intracranial hypotension (SIH), the treatment strategy ought to be modified, as classical treatment could lead to unwanted consequences. A 59-year-old man presented with a case of SI... περισσότερα »
Evaluation of Non-Watertight Dural Reconstruction with Collagen Matrix Onlay Graft in Posterior Fossa Surgery.
*Evaluation of Non-Watertight Dural Reconstruction with Collagen Matrix Onlay Graft in Posterior Fossa Surgery.* J Korean Neurosurg Soc. 2016 Jan;59(1):52-7 Authors: Kshettry VR, Lobo B, Lim J, Sade B, Oya S, Lee JH Abstract OBJECTIVE: Many surgeons advocate for watertight dural reconstruction after posterior fossa surgery given the significant risk of cerebrospinal fluid (CSF) leak. Little evidence exists for posterior fossa dural reconstruction utilizing monolayer collagen matrix onlay graft in a non-watertight fashion. Our objective was to report the results of using collagen m... περισσότερα »
Molecules, Vol. 21, Pages 230: New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells
The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and functionalities at position 2 is described. The synthesized compounds were evaluated for their in vitro anti-cancer activities on five cancer cell lines using 5-FU as reference compound. The results revealed that the benzohydrazide derivative 9a induced growth inhibition in human breast cancer cell line MCF-7 with an IC50 value of 2 μM and it showed lower cytotoxicity on MCF-12a normal breast epithelial cells. Additionally, 9a induced apoptotic morphological changes and induced apoptosis in MCF... περισσότερα »
Sorafenib combined with radiofrequency ablation in the treatment of a patient with renal cell carcinoma plus primary hepatocellular carcinoma.
Related Articles *Sorafenib combined with radiofrequency ablation in the treatment of a patient with renal cell carcinoma plus primary hepatocellular carcinoma.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1026 Authors: Gang G, Hongkai Y, Xu Z Abstract The combination of renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) is extremely rare, and the prognosis for patients with these two cancers is poor. In the past decade, molecular targeted therapy and radiofrequency ablation (RFA) have emerged and these treatments are now playing an increasingly important role in the managem... περισσότερα »
Primary diffuse large B-cell lymphoma of the prostate: A report of two cases with diagnostic considerations.
Related Articles *Primary diffuse large B-cell lymphoma of the prostate: A report of two cases with diagnostic considerations.* J Cancer Res Ther. 2015 Oct-Dec;11(4):977-9 Authors: Kakkar A, Rajeshwari M, Bhethanabhotla S, Kaur K, Jain D, Gogia A, Ray R, Seth A Abstract Primary prostatic lymphomas are extremely unusual neoplasms. Their rarity and nonspecific symptomatology at presentation usually prompt a clinical diagnosis of benign prostatic hyperplasia or chronic prostatitis, leading to significant delay in diagnosis. Clinical examination, serum prostate-specific antigen leve... περισσότερα »
Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients.
Related Articles *Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients.* Cancer Med. 2016 Feb 16; Authors: Fotouhi Ghiam A, Dawson LA, Abuzeid W, Rauth S, Jang RW, Horlick E, Bezjak A Abstract Cardiac metastases (CM), although a rare manifestation of metastatic cancer, are increasing in incidence with the improved prognosis and increased longevity of many patients with cancer. This condition may be life-threatening, especially for bulky rapidly growing tumors. Such cancer presentations may be amen... περισσότερα »
Case 227: Endobronchial Carcinoid Tumor with Incidental Metastatic Breast Cancer Detected with Somatostatin Receptor Scintigraphy ((111)In Pentreotide).
*Case 227: Endobronchial Carcinoid Tumor with Incidental Metastatic Breast Cancer Detected with Somatostatin Receptor Scintigraphy ((111)In Pentreotide).* Radiology. 2016 Mar;278(3):949-955 Authors: Raslan OA, Parkar ND, Muzaffar R, Doherty C, Osman MM Abstract History A 30-year-old woman with polycystic ovarian syndrome who was undergoing hormone replacement therapy presented with a 6-month history of a nonproductive cough and a 1-day history of hemoptysis (approximately 20 mL). Intravenous contrast material-enhanced (100 mL of Omnipaque 350; GE Healthcare, Princeton, NJ) comput... περισσότερα »
Case 231.
*Case 231.* Radiology. 2016 Mar;278(3):944-948 Authors: Bhatia V, Sharma S, Sood S, Mardi K, Venkat B PMID: 26885735 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1ot9GUD via IFTTT
The Radiology Report: A Guide to Thoughtful Communication for Radiologists and Other Medical Professionals Curtis P. Langlotz CreateSpace , 2015 . ISBN 978-1515174080 . Softcover, $17.95, 274 pp .
*The Radiology Report: A Guide to Thoughtful Communication for Radiologists and Other Medical Professionals Curtis P. Langlotz CreateSpace , 2015 . ISBN 978-1515174080 . Softcover, $17.95, 274 pp .* Radiology. 2016 Mar;278(3):677-678 Authors: PMID: 26885734 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1R9ClXR via IFTTT
State of the Art: Clinical Applications of Cardiac T1 Mapping.
*State of the Art: Clinical Applications of Cardiac T1 Mapping.* Radiology. 2016 Mar;278(3):658-676 Authors: Schelbert EB, Messroghli DR Abstract While cardiovascular magnetic resonance (MR) has become the noninvasive tool of choice for the assessment of myocardial viability and for the detection of acute myocardial edema, cardiac T1 mapping is believed to further extend the ability of cardiovascular MR to characterize the myocardium. Fundamentally, cardiovascular MR can improve diagnosis of disease that historically has been challenging to establish with other imaging modalities... περισσότερα »
Nocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Nocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study.* Allergy. 2015 Jun;70(6):697-702 Authors: Schiöler L, Ruth M, Jõgi R, Gislason T, Storaas T, Janson C, Forsberg B, Sigsgaard T, Torén K, Hellgren J Abstract BACKGROUND: It has been suggested that gastroesophageal reflux disease (GERD) is a risk factor for developing rhinitis/rhinosinusitis, but data are lacking. This is a prospective 10-year follow-up study of a large multicenter cohort from Northern Europe, evaluating the relationship ... περισσότερα »
Mast cells or not? - CD117 positive cells in esophageal leiomyoma.
[image: http:--http://ift.tt/1Lgz4kT] Related Articles *Mast cells or not? - CD117 positive cells in esophageal leiomyoma.* Histol Histopathol. 2015 May;30(5):581-8 Authors: Ye JX, Liu Y, Qin Y, Ma XL, Zhong HH, Zhang Y, Shi XY Abstract The presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive c... περισσότερα »
Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.
[image: http:--production.springer.de-OnlineReso] Related Articles *Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.* Surg Endosc. 2015 Aug;29(8):2291-7 Authors: Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR, Frisella MM, Michael Brunt L, Matthews BD Abstract PURPOSE: The objective of this study was to evaluate the performance of acellular human dermis reinforcement during laparoscopic hiatal hernia repair. METHODS: A prospective non-randomized, single institution study enrolled patients undergoing laparoscopic hiatal hernia repair. Acellula... περισσότερα »
Laparoscopic repair of paraesophageal hernia with anterior gastropexy: a multicenter study.
[image: http:--production.springer.de-OnlineReso] Related Articles *Laparoscopic repair of paraesophageal hernia with anterior gastropexy: a multicenter study.* Surg Endosc. 2015 Jul;29(7):1856-61 Authors: Daigle CR, Funch-Jensen P, Calatayud D, Rask P, Jacobsen B, Grantcharov TP Abstract BACKGROUND: The approach to repair of paraesophageal hernias (PEHs) is controversial. Recent data suggest that mesh repair leads to recurrence rates similar to non-mesh approaches, while subjecting patients to mesh-associated complications. Routine fundoplication during PEH repair has been favo... περισσότερα »
Tissue factor is unregulated in microvascular endothelial cells of patients with heart failure
Aims Several lines of evidence point to hypercoagulability as an important factor for heart failure (HF) pathogenesis. Methods We hypothesised that endothelial tissue factor (TF) expression reflects altered tissue haemostasis which is related to the severity of HF. Accordingly, we investigated TF expression in the biopsies of 60 patients with HF and 22 without HF. In addition, we assessed the relationship between endothelial TF expression and clinical markers of HF severity. Results The control subjects without HF presented absent or weak TF expression in few microvessels, whil... περισσότερα »
The importance of tissue handling of surgically removed breast cancer for an accurate assessment of the Ki-67 index
Aim Insufficient attention for the Ki-67 immunohistochemistry has been given to the importance of tissue handling for surgical breast cancer specimens. We sought to investigate the effect of fixation status on the Ki-67. Methods We examined the effect of fixative, time to and duration of fixation using surgical specimens, and finally, compared the paired Ki-67 index in the tumour between core needle and surgical specimen. Results The Ki-67 was significantly higher when 10% neutral buffered formalin was used (p=0.0276). Insufficient fixation caused a drastic reduction in the Ki-... περισσότερα »
Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C
Background Oxidative stress may play pathogenic roles in the mechanisms underlying chronic hepatitis C (CHC). The impact of excessive oxidative stress and iron dysregulation on the development of hepatocellular carcinoma (HCC) after interferon therapy has not been established. Methods We investigated the impact of oxidative stress and iron deposition on HCC development after therapy with pegylated interferon (PegIFN)+ribavirin in CHC patients. Systemic and intracellular iron homeostasis was evaluated in liver tissues, peripheral blood mononuclear cells and sera. Results Of 203 ... περισσότερα »
UK cancer cases soar by 12% since mid-90s to 352,000 each year https://t.co/r6QQ8OwLQb
UK cancer cases soar by 12% since mid-90s to 352,000 each year https://t.co/r6QQ8OwLQb from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/700268815037235200 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/210HEky via IFTTT
JCDD, Vol. 3, Pages 7: Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly
Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional heart phenotypes. Identification of molecular and functional mechanisms disrupted by mutations causing channelopathies and cardiomyopathies is essential to understanding the link between an altered gene and clinical phenotype. The development of animal models has been proven to be efficient for functional studies in channelopathies a... περισσότερα »
IJMS, Vol. 17, Pages 253: Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation
Various stem cells gradually turned to be critical players in tissue engineering and regenerative medicine therapies. Current evidence has demonstrated that in addition to growth factors and the extracellular matrix, multiple metabolic pathways definitively provide important signals for stem cell self-renewal and differentiation. In this review, we mainly focus on a detailed overview of stem cell metabolism in vitro. In stem cell metabolic biology, the dynamic balance of each type of stem cell can vary according to the properties of each cell type, and they share some common point... περισσότερα »
‘Ecologically diverse’ breast cancers more likely to be deadly
Breast cancers which are particularly complex and diverse, as judged by a test used in ecology to analyse species of animals and plants, are particularly likely to progress and lead to death, a new study shows. The test could be used in the clinic to… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Vpq5nn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21auAWm via IFTTT
Effect of different doses of monosodium glutamate on the thyroid follicular cells of adult male albino rats: a histological study.
*Effect of different doses of monosodium glutamate on the thyroid follicular cells of adult male albino rats: a histological study.* Int J Clin Exp Pathol. 2015;8(12):15498-510 Authors: Khalaf HA, Arafat EA Abstract Monosodium glutamate (MSG) is a major flavor enhancer used as a food additive. The present study investigates the effects of different doses of MSG on the morphometric and histological changes of the thyroid gland. 28 male albino rats were used. The rats were divided into four groups: group I control, group II, III and IV treated with MSG (0.25 g/kg, 3 g/kg, 6 g/kg da... περισσότερα »
Comparison of the RECIST 1.0 and RECIST 1.1 in patients treated with targeted agents: a pooled analysis and review.
*Comparison of the RECIST 1.0 and RECIST 1.1 in patients treated with targeted agents: a pooled analysis and review.* Oncotarget. 2016 Feb 11; Authors: Kim JH Abstract Patients treated with targeted agents were not included in the data warehouse when the RECIST 1.1 was revised in 2009. We conducted this pooled analysis to investigate the impact of the RECIST 1.1 on the assessment of tumor response in cancer patients treated with targeted agents. We surveyed MEDLINE, EMBASE and PubMed for articles with terms of the RECIST 1.0 or RECIST 1.1. We searched for all the references of re... περισσότερα »
Sleep disparity, race/ethnicity, and socioeconomic position
[image: 1-s2.0-S1389945715X00165-cov150h.gif] Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 Author(s): Michael A. Grandner, Natasha J. Williams, Kristen L. Knutson, Dorothy Roberts, Girardin Jean-Louis Sleep represents a set of biological functions necessary for the maintenance of life. Performing these functions, though, requires that an individual engage in behaviors, which are affected by social and environmental factors. Race/ethnicity and socioeconomic position represent categories of factors that likely play a role in the experience of sleep in the communi... περισσότερα »
Disparities and genetic risk factors in obstructive sleep apnea
[image: 1-s2.0-S1389945715X00165-cov150h.gif] Publication date: February 2016 *Source:*Sleep Medicine, Volume 18 Author(s): Katherine A. Dudley, Sanjay R. Patel Obstructive sleep apnea (OSA) is an increasingly prevalent condition. A growing body of literature supports substantial racial disparities in the prevalence, risk factors, presentation, diagnosis, and treatment of this disease. Craniofacial structure among Asians appears to confer an elevated risk of OSA despite lower rates of obesity. Among African Americans, Native Americans, and Hispanics, OSA prevalence is increased, like... περισσότερα »
Mechanisms and therapeutic effectiveness of lactobacilli
The gut microbiome is not a silent ecosystem but exerts several physiological and immunological functions. For many decades, lactobacilli have been used as an effective therapy for treatment of several pathological conditions displaying an overall positive safety profile. This review summarises the mechanisms and clinical evidence supporting therapeutic efficacy of lactobacilli. We searched Pubmed/Medline using… Continue reading Mechanisms and therapeutic effectiveness of lactobacilli
Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer.
Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer. Int J Clin Exp Pathol. 2015;8(12):16007-13 Authors: He J, Li J, Feng W, Chen L, Yang K Abstract Interferon-induced transmembrane protein 1 (IFITM1) has recently been implicated in tumorigenesis. However, the prognostic value of IFITM1 in colorectal cancer remains unknown. The present study aimed to… Continue reading Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer.
Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series
Aims Denosumab, a fully human monoclonal antibody directed against RANKL, has recently been introduced in the treatment strategy of giant cell tumour of bone (GCTB). Aim of this study was to investigate the phenotypical modifications induced by denosumab treatment in a series of 15 GCTB. Methods The tumours were characterised for histone 3.3 mutations, and… Continue reading Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series
Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.
Serum Interleukin-33 level in Saudi children with inflammatory bowel disease. Int J Clin Exp Pathol. 2015;8(12):16000-6 Authors: Saadah OI, Al-Harthi SE, Al-Mughales JA, Bin-Taleb YY, Baeshen RS Abstract Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was… Continue reading Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.
Case 5-2016: A 43-Year-Old Man with Altered Mental Status and a History of Alcohol Use
Presentation of Case. Dr. Sarah K. Bourne (Neurosurgery): A 43-year-old man with a history of alcohol-use disorder was admitted to this hospital because of altered mental status. On the day of admission, the patient was found by emergency medical services personnel, who had been contacted by a… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RPRobt via… Continue reading Case 5-2016: A 43-Year-Old Man with Altered Mental Status and a History of Alcohol Use
The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study
Publication date: Available online 17 February 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): J.C. de Vicente, I. Peña, P. Braña, G. Hernández-Vallejo A prospective study was conducted to assess a variation of inferior alveolar nerve (IAN) lateralization. This study included 13 patients. An osteotomy was made with a piezoelectric device, and the IAN… Continue reading The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study
Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expres sion in rats
Publication date: Available online 18 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Paola I. Ingaramo, María M. Milesi, Marlise Guerrero Schimpf, Jorge G. Ramos, Lucía Vigezzi, Mónica Muñoz-de-Toro, Enrique H. Luque, Jorgelina Varayoud Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and β-catenin during uterine development leading to the… Continue reading Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expres sion in rats
Gut Sampling with IntelliCap
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 1 ώρα
Microbiota Sampling Exploring the link between the gut microbiome and health [image: body_image] *Breakthrough in Non-invasive sampling* Medimetrics announces successful sampling and profiling of *small bowel *microbiota with their swallowed IntelliCap® capsule that passes naturally through the digestive system. Publication of the first clinical study of NIZO food research, Wageningen University and Medimetrics in 2016. IntelliCap® CR for sampling • Electronically controlled capsule • Fluid aspiration at defined location • Genetic analysis of contents Medime... περισσότερα »
Gut Sampling with IntelliCap
Microbiota Sampling Exploring the link between the gut microbiome and health [image: body_image] *Breakthrough in Non-invasive sampling* Medimetrics announces successful sampling and profiling of *small bowel *microbiota with their swallowed IntelliCap® capsule that passes naturally through the digestive system. Publication of the first clinical study of NIZO food research, Wageningen University and Medimetrics in 2016. IntelliCap® CR for sampling • Electronically controlled capsule • Fluid aspiration at defined location • Genetic analysis of contents Medime... περισσότερα »
Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aims Denosumab, a fully human monoclonal antibody directed against RANKL, has recently been introduced in the treatment strategy of giant cell tumour of bone (GCTB). Aim of this study was to investigate the phenotypical modifications induced by denosumab treatment in a series of 15 GCTB. Methods The tumours were characterised for histone 3.3 mutations, and […]
The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 February 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): J.C. de Vicente, I. Peña, P. Braña, G. Hernández-Vallejo A prospective study was conducted to assess a variation of inferior alveolar nerve (IAN) lateralization. This study included 13 patients. An osteotomy was made with a piezoelectric device, and the IAN […]
Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expres sion in rats
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Paola I. Ingaramo, María M. Milesi, Marlise Guerrero Schimpf, Jorge G. Ramos, Lucía Vigezzi, Mónica Muñoz-de-Toro, Enrique H. Luque, Jorgelina Varayoud Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and β-catenin during uterine development leading to the […]
Muscle strengthening activities and mortality with considerations by hearing sensitivity.
*Muscle strengthening activities and mortality with considerations by hearing sensitivity.* Int J Audiol. 2016 Feb 17;:1-3 Authors: Loprinzi PD Abstract OBJECTIVE: Research demonstrates that hearing impairment is associated with premature all-cause mortality. Emerging work indicates that physical activity is associated with hearing sensitivity and muscle strengthening activities (MSA) are favorably associated mortality in the general population. Whether MSA can promote survival among those with hearing impairment is, at this point, unknown, which was this study's objective. DESIG... περισσότερα »
Muscle strengthening activities and mortality with considerations by hearing sensitivity.
*Muscle strengthening activities and mortality with considerations by hearing sensitivity.* Int J Audiol. 2016 Feb 17;:1-3 Authors: Loprinzi PD Abstract OBJECTIVE: Research demonstrates that hearing impairment is associated with premature all-cause mortality. Emerging work indicates that physical activity is associated with hearing sensitivity and muscle strengthening activities (MSA) are favorably associated mortality in the general population. Whether MSA can promote survival among those with hearing impairment is, at this point, unknown, which was this study's objective. DESIG... περισσότερα »
Muscle strengthening activities and mortality with considerations by hearing sensitivity
10.3109/14992027.2016.1140233<br>Paul D. Loprinzi from #Audiology via ola Kala on Inoreader http://ift.tt/1ot230p via IFTTT
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.
Objectives: Listening to speech with multiple competing talkers requires the perceptual separation of the target voice from the interfering background. Normal-hearing listeners are able to take advantage of perceived differences in the spatial locations of competing sound sources to facilitate this process. Previous research suggests that bilateral (BI) cochlear-implant (CI) listeners cannot do so, and it is unknown whether single-sided deaf (SSD) CI users (one acoustic and one CI ear) have this ability. This study investigated whether providing a second ear via cochlear implantatio... περισσότερα »
Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.
*Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.* Int J Clin Exp Pathol. 2015;8(12):15977-84 Authors: Janevska V, Qerimi A, Basheska N, Stojkova E, Janevski V, Jovanovic R, Zhivadinovik J, Spasevska L Abstract OBJECTIVE: Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which may show diverse differentiation. There are reports in which cells morphologically identical to the interstitial cells of Cajal are found in deep leiomyomas. The aim of this study was to demonstrate CD117 positive cells in superficia... περισσότερα »
Clinico-pathological characteristics and prognostic factors of gastrointestinal stromal tumors among a Chinese population.
*Clinico-pathological characteristics and prognostic factors of gastrointestinal stromal tumors among a Chinese population.* Int J Clin Exp Pathol. 2015;8(12):15969-76 Authors: Li J, Zhang H, Chen Z, Su K Abstract Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal tumors of the digestive tract. GISTs include a group of heterogeneous tumors with different morphology, biologic behavior, and genetic characteristics, so their epidemiology, clinico-pathological features and prognosis is distinct in different countries. The objective of this study is to ana... περισσότερα »
Differences in extension patterns between adenoid cystic carcinoma of the nasopharynx and nasopharyngeal carcinoma on MRI.
*Differences in extension patterns between adenoid cystic carcinoma of the nasopharynx and nasopharyngeal carcinoma on MRI.* Int J Clin Exp Pathol. 2015;8(12):15960-8 Authors: Dong J, Tian L, Li S, Mo Y, Liu L, Zhong R Abstract OBJECTIVE: This study aimed to map differences in extension patterns between adenoid cystic carcinoma (ACC) of the nasopharynxandnasopharyngeal carcinomaon magnetic resonance imaging (MRI) and provide more information for treatments. METHODS: MRI examinations and clinical records were reviewed in 18 patients with ACC of the nasopharynx and 182 patients with... περισσότερα »
Rivaroxaban and retropharyngeal haemorrhage.
*Rivaroxaban and retropharyngeal haemorrhage.* BMJ Case Rep. 2016;2016 Authors: McCarter JA, Bell PR, McCadden L, Scally C Abstract Haemorrhage is a well-known and accepted complication of anticoagulation. A retropharyngeal haemorrhage (RH) is a rare condition that without prompt recognition and management may result in fatal complications. We report a case of RH in a 67-year-old man anticoagulated with rivaroxaban for atrial fibrillation. The patient presented to the emergency department, with a two-day history of atraumatic right-sided neck swelling and associated progressive o... περισσότερα »
Large pedunculated lipoma of the esophagus: Report of a case and review of literature.
Related Articles *Large pedunculated lipoma of the esophagus: Report of a case and review of literature.* J Cancer Res Ther. 2015 Oct-Dec;11(4):1031 Authors: Qinying W, Wei L, Shuihong Z Abstract Large pedunculated esophageal lipoma is uncommon. The presenting symptoms of esophageal lipoma are dysphagia, regurgitated mass, and persistent sensation of a lump in the throat. The most frequent location of the tumor pedicle is the upper esophageal sphincter. Here, we present the case of a 52-year-old man who had the symptoms of pharyngeal unwell and dysphagia. Panendoscopy showed a p... περισσότερα »
Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.* J Dermatol. 2014 Oct;41(10):872-7 Authors: Nakamura Y, Fujisawa Y, Teramoto Y, Sato S, Yamada K, Sekine K, Fujimoto M, Otsuka F, Yamamoto A Abstract Subungual melanoma (SUM) is rare and represents approximately 2-3% and 20% of all cutaneous melanomas in Caucasians and Asians, respectively. Amputation has usually been performed for invasive SUM; however, not all invasive SUMs invade or attach to the distal phalanx. To investigate the ... περισσότερα »
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.* PLoS One. 2015;10(3):e0122662 Authors: Wadt KA, Aoude LG, Krogh L, Sunde L, Bojesen A, Grønskov K, Wartacz N, Ek J, Tolstrup-Andersen M, Klarskov-Andersen M, Borg Å, Heegaard S, Kiilgaard JF, Hansen TV, Klein K, Jönsson G, Drzewiecki KT, Dunø M, Hayward NK, Gerdes AM Abstract Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depen... περισσότερα »
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
[image: NEJMCat_eventglobal_header.gif] The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma
Cancer from melanoma2 via als.fakia on Inoreader http://ift.tt/1Q2XaFg via IFTTT
Diffusion tensor imaging of cervical spinal cord: A quantitative diagnostic tool in cervical spondylotic myelopathy
*Zafer Orkun Toktas, Bahattin Tanrikulu, Orkun Koban, Turker Kilic, Deniz Konya* Journal of Craniovertebral Junction and Spine 2016 7(1):26-30 Background: Diffusion tensor imaging (DTI) is a novel magnetic resonance imaging (MRI) technique potentially able to evaluate the microscopic structural organization of white matter fibers. Aim: This study aimed to compare fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values obtained by DTI in stenotic versus nonstenotic cervical spinal segments of patients with clinical and neurological evidence of cervical spondylotic... περισσότερα »
Accurate Elastomeric Impressions: The Importance of Effective Soft Tissue Management
from #Dental via xlomafota13 on Inoreader http://ift.tt/1Qnr3vR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Recurrent craniospinal epidermoid: A case report
*Abhidha Shah, Manoj Patil, Atul Goel* Journal of Craniovertebral Junction and Spine 2016 7(1):59-61 We present a rare case of a fourth ventricular epidermoid cyst, which recurred 15 years after the initial radical tumor resection surgery. The recurrence of the tumor extended into the cervical spine. The patient was reoperated and a near-total excision of both the cranial and spinal components of the epidermoid was performed. Our literature search did not reveal any case where there was a simultaneous presence of both the cranial and spinal epidermoid tumors. The possible cause of e... περισσότερα »
An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery
Abstract Bimaxillary orthognathic surgery has been widely performed to achieve optimal functional and esthetic outcomes in patients with dentofacial deformity. Although Le Fort I osteotomy is generally performed before bilateral sagittal split osteotomy (BSSO) in the surgery, in several situations BSSO should be performed first. However, it is very difficult during bimaxillary orthognathic surgery to maintain an accurate centric relation of the condyle and decide the ideal vertical dimension from the skull base to the mandible. We have previously applied a straight locking minipla... περισσότερα »
Upright magnetic resonance imaging of the lumbar spine: Back pain and radiculopathy
*Ha Son Nguyen, Ninh Doan, Saman Shabani, Jamie Baisden, Christopher Wolfla, Glenn Paskoff, Barry Shender, Brian Stemper* Journal of Craniovertebral Junction and Spine 2016 7(1):31-37 Background: Lumbar back pain and radiculopathy are common diagnoses. Unfortunately, conventional magnetic resonance imaging (MRI) findings and clinical symptoms do not necessarily correlate in the lumbar spine. With upright imaging, disc pathologies or foraminal stenosis may become more salient, leading to improvements in diagnosis. Materials and Methods: Seventeen adults (10 asymptomatic and 7 symptom... περισσότερα »
IJMS, Vol. 17, Pages 251: Metabolic Activity of Radish Sprouts Derived Isothiocyanates in Drosophila melanogaster
We used Drosophila melanogaster as a model system to study the absorption, metabolism and potential health benefits of plant bioactives derived from radish sprouts (Raphanus sativus cv. Rambo), a Brassicaceae species rich in glucosinolates and other phytochemicals. Flies were subjected to a diet supplemented with lyophilized radish sprouts (10.6 g/L) for 10 days, containing high amounts of glucoraphenin and glucoraphasatin, which can be hydrolyzed by myrosinase to the isothiocyanates sulforaphene and raphasatin, respectively. We demonstrate that Drosophila melanogaster takes up an... περισσότερα »
Table of Contents
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1R9y6LP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21auzBH via IFTTT
Society Information
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QmwAcc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/210HFF3 via IFTTT
The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 February 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): J.C. de Vicente, I. Peña, P. Braña, G. Hernández-Vallejo A prospective study was conducted to assess a variation of inferior alveolar nerve (IAN) lateralization. This study included 13 patients. An osteotomy was made with a piezoelectric device, and the IAN […]
Ameloblastomas of the mandible and maxilla.
Purpose of review: This review focuses on issues in managing ameloblastomas of the mandible and maxilla. We will refer to current practice in the treatment of ameloblastomas based on the available evidence. Recent findings: Recent reviews have been trying to establish natural history, growth patterns and malignant potential. This provides the clinicians and the patients… Continue reading Ameloblastomas of the mandible and maxilla.
Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices.
Purpose of review: This article critically analyzes the recent literature on microvascular head and neck reconstruction after (chemo)radiation [(C)RT], taking into consideration both the underlying pathogenetic mechanisms and their clinical consequences. Recent findings: Microvascular reconstruction has gradually become a mainstay in the management of head and neck cancer both in primary and salvage scenarios. However,… Continue reading Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices.
Allergy and laryngeal disorders.
Purpose of review: This article reviews recent literature on the topic of allergic laryngitis. There has been sustained interest over the past 15 years and epidemiological and experimental studies have led to a clearer description of the nature of the condition and its clinical expression. Recent findings: Recent studies have suggested an epidemiological association between… Continue reading Allergy and laryngeal disorders.
The role of allergy immunotherapy in the treatment of asthma.
Purpose of review: Asthma and allergic rhinitis are two of the most widespread chronic medical conditions. Asthma, a condition which encompasses chronic inflammation of the lower airway resulting in expiratory obstruction, may represent an end phase along the allergic disease spectrum ultimately stemming initially from nasal allergic rhinitis and bronchial hyper-reactivity. The purpose of this… Continue reading The role of allergy immunotherapy in the treatment of asthma.
NMDA and non-NMDA glutamate receptors in the paraventricular nucleus of the hypothalamus modulate different stages of hemorrhage-evoked cardiovascular responses in rats
Publication date: 21 April 2016 Source:Neuroscience, Volume 320 Author(s): C. Busnardo, C.C. Crestani, A. Fassini, L.B.M. Resstel, F.M.A. Corrêa Here we report the involvement of N-Methyl-d-Aspartate (NMDA) and non-NMDA glutamate receptors from the paraventricular nucleus of the hypothalamus (PVN) in the mediation of cardiovascular changes observed during hemorrhage and post-bleeding periods. In addition, the present… Continue reading NMDA and non-NMDA glutamate receptors in the paraventricular nucleus of the hypothalamus modulate different stages of hemorrhage-evoked cardiovascular ... περισσότερα »
Sex differences in the outcome of juvenile social isolation on HPA axis function in rats
Publication date: 21 April 2016 Source:Neuroscience, Volume 320 Author(s): M.G. Pisu, A. Garau, G. Boero, F. Biggio, V. Pibiri, R. Dore, V. Locci, E. Paci, P. Porcu, M. Serra Women are more likely than men to suffer from anxiety disorders and major depression. These disorders share hyperresponsiveness to stress as an etiological factor. Thus, sex… Continue reading Sex differences in the outcome of juvenile social isolation on HPA axis function in rats
Phase I Trial of Dose-escalated Whole Liver Irradiation With Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridine/Leucovorin and Chemoembolization for Patients With Neuroendocrine Hepatic Metastases.
Objectives: We have previously shown that refractory neuroendocrine tumors can respond to moderate doses of chemoradiotherapy. We completed a dose-escalation phase I/II trial combining hepatic arterial (HA) chemotherapy, chemoembolization, and dose-escalated whole liver radiotherapy to determine the maximum safe dose of radiation that could be delivered and to make a preliminary assessment of response. Materials… Continue reading Phase I Trial of Dose-escalated Whole Liver Irradiation With Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridi... περισσότερα »
Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Tumor-to-bone distance of invasive subungual melanoma: an analysis of 30 cases.* J Dermatol. 2014 Oct;41(10):872-7 Authors: Nakamura Y, Fujisawa Y, Teramoto Y, Sato S, Yamada K, Sekine K, Fujimoto M, Otsuka F, Yamamoto A Abstract Subungual melanoma (SUM) is rare and represents approximately 2-3% and 20% of all cutaneous melanomas in Caucasians and Asians, respectively. Amputation has usually been performed for invasive SUM; however, not all invasive SUMs invade or attach to the distal phalanx. To investigate the ... περισσότερα »
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.* PLoS One. 2015;10(3):e0122662 Authors: Wadt KA, Aoude LG, Krogh L, Sunde L, Bojesen A, Grønskov K, Wartacz N, Ek J, Tolstrup-Andersen M, Klarskov-Andersen M, Borg Å, Heegaard S, Kiilgaard JF, Hansen TV, Klein K, Jönsson G, Drzewiecki KT, Dunø M, Hayward NK, Gerdes AM Abstract Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depen... περισσότερα »
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
[image: NEJMCat_eventglobal_header.gif] The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma
Cancer from melanoma2 via als.fakia on Inoreader http://ift.tt/1Q2XaFg via IFTTT
Epigenetic Modulators and the New Immunotherapies
[image: NEJMCat_eventglobal_header.gif] The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Epigenetic Modulators and the New Immunotherapies
The recent arrival of the immune-checkpoint–inhibitor drugs — first applied to melanoma and more recently tested as a treatment for different solid tumors and hematologic cancers — has changed the management of these conditions. The response rates have been impressive, as have the… from melanoma2 via als.fakia on Inoreader http://ift.tt/1QnxpLV via IFTTT
Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma
Cancer from melanoma2 via als.fakia on Inoreader http://ift.tt/1Q2XaFg via IFTTT
Issue Information – Table of Contents
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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IJMS, Vol. 17, Pages 249: Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae) is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects […]
Biomimetic phantom for cardiac diffusion MRI
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Purpose Diffusion magnetic resonance imaging (MRI) is increasingly used to characterize cardiac tissue microstructure, necessitating the use of physiologically relevant phantoms for methods development. Existing phantoms are generally simplistic and mostly simulate diffusion in the brain. Thus, there is a need for phantoms mimicking diffusion in cardiac tissue. Materials and Methods A biomimetic phantom composed […]
IJMS, Vol. 17, Pages 246: Systems Pharmacology in Small Molecular Drug Discovery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures […]
Acromio-axillo-suprasternal notch index: a new screening test to predict difficult laryngoscopy in obstetric patients scheduled for caesarean delivery.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oLMaSy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q30Gzx via IFTTT
IJMS, Vol. 17, Pages 160: The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through […]
Stage I and II Endometrial Adenocarcinoma: Analysis of 2009 FIGO Staging Revision and Impact on Survival by Adjuvant Therapy.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Background: In 2009, the International Federation of Gynecology and Obstetrics revised the staging classification for endometrial cancer. Mucosal cervical involvement was eliminated from the criteria and only those with stromal cervical involvement were considered stage II. We examined the implications of the staging changes and the survival impact of adjuvant therapy in stage I to […]
Petrus Aureoli: Scriptum super primum Sententiarum, distinctio 37
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Epigenetik und Erbsünde. Theologisch-ethische Reflexionen zu Erblichkeit und Verantwortung
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Uhrmacher
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Insbesondere in der Schweiz entwickelten sich Herstellung und Handel von Uhren zu charakteristischen Berufsfeldern von Juden. Seit Mitte des 19. Jahrhunderts etablierten sich dort jüdische Händler, Handwerker und Fabrikanten. Als sich in den 1870er Jahren mit dem Aufkommen günstiger Uhren aus den Vereinigten Staaten die handwerkliche Produktion in der Schweiz als rückständig erwies, fiel es […]
Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.
[image: http:--production.springer.de-OnlineReso] Related Articles *Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair.* Surg Endosc. 2015 Aug;29(8):2291-7 Authors: Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR, Frisella MM, Michael Brunt L, Matthews BD Abstract PURPOSE: The objective of this study was to evaluate the performance of acellular human dermis reinforcement during laparoscopic hiatal hernia repair. METHODS: A prospective non-randomized, single institution study enrolled patients undergoing laparoscopic hiatal hernia repair. Acellula... περισσότερα »
Muscle strengthening activities and mortality with considerations by hearing sensitivity
10.3109/14992027.2016.1140233<br>Paul D. Loprinzi from #Audiology via xlomafota13 on Inoreader http://ift.tt/1ot230p via IFTTT
Cosmetics, Vol. 3, Pages 5: Cosmetic Contact Allergens
This article presents trends in the frequency of cosmetics as causal factors of allergic contact dermatitis during a 26-year period in 14,911 patients patch-tested between 1990 and 2014, and discusses the cosmetic allergens identified during the last six years (2010–2015) in 603 patients out of 3105 tested. The data were retrieved from, and evaluated with, a patient database developed in-house. The results show the increasing importance of cosmetic allergies, up to 25% of the patients tested during the last five-year period. As expected, fragrance materials, preservatives, and hai... περισσότερα »
Characterisation of graphene fibres and graphene coated fibres using capacitively coupled contactless conductivity detector
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02534F, Paper Joan-Marc Cabot Canyelles, emer duffy, Sinead Currivan, Andres Ruland Palaia, Rouhollah Jalili, Attila Janos Mozer, Peter Charles Innis, Gordon Wallace, Michael C Breadmore, Brett Paull The use of capacitively coupled contactless conductivity detection (C4D) for the characterisation of thin conductive graphene fibres, graphene composite fibres, and graphene coated fibrous materials is demonstrated for the first... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicin... περισσότερα »
DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by down-regulating the EGFR/AKT pathway in esophageal squamous cell carcinoma
International Journal of Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/1STQQTp Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
How should HCV treatment be prioritized in the direct-acting antiviral era? An economic evaluation including population prevention benefits
Journal of Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20FQPBe Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Quantification of respiration-induced esophageal tumor motion using fiducial markers and four-dimensional computed tomography
Radiotherapy & Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/20FQQVN Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Coffee consumption protects against progression in liver cirrhosis and increases long-term survival after liver transplantation
Journal of Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20FQPkN Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The influence of gastric cancer screening on the stage at diagnosis and survival: A meta-analysis of comparative studies in the Far East
Journal of Clinical Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1STQPi4 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sorafenib combined with transarterial chemoembolization in patients with hepatocellular carcinoma: a meta-analysis and systematic review
Hepatology International from #Medicine via ola Kala on Inoreader http://ift.tt/20FQQoJ Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Intestinal tuberculosis and Crohn's disease: Challenging Differential Diagnosis
Journal of Digestive Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/20FQONH Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection
Journal of Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20FQOxm Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Clinical impact of combined transarterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: An external validation study
Radiotherapy & Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/20FQNcI Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study
[image: alertIcon.gif] Publication date: Available online 17 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): J.C. de Vicente, I. Peña, P. Braña, G. Hernández-Vallejo A prospective study was conducted to assess a variation of inferior alveolar nerve (IAN) lateralization. This study included 13 patients. An osteotomy was made with a piezoelectric device, and the IAN bundle was moved buccally. Dental implants were then inserted medial to the nerve bundle, and the inner surface of the buccal cortical bone plate was shaped to reduce its thickness.... περισσότερα »
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Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study aimed to contribute to the evidence of the effectiveness of water protocols with a particular emphasis on health outcomes, especially hydration. An RCT was conducted with patients with known thin liquid aspiration post stroke randomized to receiving thickened liquids only or a water protocol. For the 14 participants in rehabilitation facilities whose data […]
Abnormal Neural Basis of Emotional Conflict Control in Treatment-Resistant Depression: An Event-Related Potential Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Emotional conflict has received increased attention as a research topic. The objective of this study is to confirm that the processing of emotional conflict is impaired in treatment-resistant depression (TRD). We compared the event-related potentials of 17 patients with TRD and 17 healthy controls during the face-word Stroop task, which is an effective way of […]
Skeletal Muscle Erythropoietin Expression is Responsive to Hypoxia and Exercise.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Erythropoietin is responsible for regulating the growth and development of red blood cells. Reports conflict on whether or not skeletal muscle is able to produce erythropoietin and release it into circulation, and if exercise has an impact on this. We set out to determine how erythropoietin is regulated in skeletal muscle, and as well, […]
Ovariectomized High Fit Rats Are Protected against Diet-Induced Insulin Resistance.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
INTRODUCTION: In the absence of exercise training, rats selectively bred for high intrinsic aerobic capacity (HCR) are protected against ovariectomy (OVX)-induced insulin resistance and obesity compared to those bred for low intrinsic aerobic capacity (LCR). PURPOSE: This study determined whether OVX HCR rats remain protected with exposure to high fat diet (HFD) compared to OVX […]
Adaptations to Speed Endurance Training in Highly Trained Soccer Players.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: The present study examined whether a period of additional speed endurance training would improve intense intermittent exercise performance in highly trained soccer players during the season and whether the training changed aerobic metabolism and the level of oxidative enzymes in type I and II muscle fibers. Methods: During the last nine weeks of the […]
Clinical Management of Ebola Virus Disease in the United States and Europe
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Ebola virus disease (EVD) epidemic in West Africa had resulted in more than 28,600 reported cases and more than 11,300 deaths through December 2015; mortality reported for patients with EVD cared for in Ebola treatment units in West Africa has ranged from 37 to 74%. The provision of clinical… from #Medicine-SfakianakisAlexandros via o.lakala70 on
