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Peripheral blood eosinophilia correlates with hyperplastic nasal polyp growth
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Background Eosinophils are thought to play a significant role in nasal polyposis, but the exact mechanism by which they contribute to polyposis remains unclear. Therefore, we proposed to test the hypothesis that peripheral blood eosinophilia (PBE) is a surrogate and biomarker for polyp load. To do this, we examined whether PBE levels correlate with nasal […]
The organization of spinal motor neurons in a monotreme is consistent with a six-region schema of the mammalian spinal cord
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Abstract The motor neurons in the spinal cord of an echidna (Tachyglossus aculeatus) have been mapped in Nissl-stained sections from spinal cord segments defined by spinal nerve anatomy. A medial motor column of motor neurons is found at all spinal cord levels, and a hypaxial column is found at most levels. The organization of the […]
What’s up in YOUR Mouth: Amalgam Fillings
The post What's up in YOUR Mouth: Amalgam Fillings appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1Ortj5y via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Chronic Rejection in Human Vascularized Composite Allotransplantation (Hand and Face Recipients): An Update.
Chronic Rejection in Human Vascularized Composite Allotransplantation (Hand and Face Recipients): An Update.: Vascularized composite tissue allografts (VCA) have become a viable option to restore severely damaged parts of the body that cannot be repaired with conventional surgical techniques. Acute rejection develops frequently in the early postgraft period both in human and experimental VCA, but the possibility of human VCA to undergo chronic rejection (CR) remained initially unknown. The experience gained over the years shows that, similar to solid organ transplants (SOT), human VC...περισσότερα »
Toothpaste hardens your teeth while you sleep
British Dental Journal 220, 491 (2016). doi:10.1038/sj.bdj.2016.343 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMflRG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Dental education: Piecing the Jigsaw
British Dental Journal 220, 429 (2016). doi:10.1038/sj.bdj.2016.313 Author: M. Mercedes Suarez-Cunqueiro from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjG1PE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Experiencing the failing dentition: what dentists do
British Dental Journal 220, 479 (2016). doi:10.1038/sj.bdj.2016.335 Author: P. Hellyer from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfi8q via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Prophylaxis guidelines: Repeated points
British Dental Journal 220, 429 (2016). doi:10.1038/sj.bdj.2016.314 Authors: P. Alderson & M. Baker from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFZaD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Robert Jones
British Dental Journal 220, 494 (2016). doi:10.1038/sj.bdj.2016.351 Author: David Meacher from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfkxg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Orthodontics: Not so fast
British Dental Journal 220, 430 (2016). doi:10.1038/sj.bdj.2016.315 Author: T. Kilcoyne from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjG125 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A brand new disposable dental floss
British Dental Journal 220, 490 (2016). doi:10.1038/sj.bdj.2016.339 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfk05 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Oral cancer: A reasonable postulation
British Dental Journal 220, 430 (2016). doi:10.1038/sj.bdj.2016.316 Author: Thorakkal Shamim from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFXQ1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Actively strengthening and re-hardening enamel
British Dental Journal 220, 492 (2016). doi:10.1038/sj.bdj.2016.347 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfjt8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sugar: A latte on my mind
British Dental Journal 220, 431 (2016). doi:10.1038/sj.bdj.2016.317 Authors: L. Harris & H. Barry from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFY6v via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Representative survey on the reprocessing of endodontic instruments in Germany
British Dental Journal 220, 465 (2016). doi:10.1038/sj.bdj.2016.333 Authors: D. Sonntag, E. Martin & W. H. M. Raab from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfg0z via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
New dental hospital and school for Birmingham
British Dental Journal 220, 433 (2016). doi:10.1038/sj.bdj.2016.318 from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFXj1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Break free from conventions and eyematch intuitively
British Dental Journal 220, 489 (2016). doi:10.1038/sj.bdj.2016.337 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfg0g via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Honours, awards, appointments
British Dental Journal 220, 433 (2016). doi:10.1038/sj.bdj.2016.319 from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFUUl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Toothpaste with unique clinical benefits
British Dental Journal 220, 490 (2016). doi:10.1038/sj.bdj.2016.341 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfftf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Editor-in-chief hosts Perio Question Time
British Dental Journal 220, 433 (2016). doi:10.1038/sj.bdj.2016.320 from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFUDJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Claims against dental professionals have quadrupled
British Dental Journal 220, 491 (2016). doi:10.1038/sj.bdj.2016.345 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfchh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Feature: Diving and dentistry
British Dental Journal 220, 434 (2016). doi:10.1038/sj.bdj.2016.321 Does breathing compressed air through a mouthpiece while scuba diving have an impact on the teeth? A dentist based in the US is conducting some research to find out. from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFUn7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Brain mechanisms of semantic interference in spoken word production: An anodal transcranial Direct Current Stimulation (atDCS) study
[image: S0093934X.gif] Publication date: June–July 2016 *Source:*Brain and Language, Volumes 157–158 Author(s): Marcus Meinzer, Özlem Yetim, Katie McMahon, Greig de Zubicaray When naming pictures, categorically-related compared to unrelated contexts typically slow production. We investigated proposed roles for the left inferior frontal gyrus (LIFG) and posterior middle and superior temporal gyri (pMTG/STG) in mediating this semantic interference effect. In a three-way, cross-over, sham-controlled study, we applied online anodal transcranial Direct Current Stimulation (atDCS) to LIFG ...περισσότερα »
A Flexible UV–Vis–NIR Photodetector based on a Perovskite/Conjugated-Polymer Composite
[image: Thumbnail image of graphical abstract] *A lateral photodetector* based on the bilayer composite film of a perovskite and a conjugated polymer is reported. It exhibits significantly enhanced responsivity in the UV–vis region and sensitive photoresponse in the near-IR (NIR) region at a low applied voltage. This broadband photodetector also shows excellent mechanical flexibility and improved environmental stability. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/24PKDKV via IFTTT
Immunodominant West Nile Virus T Cell Epitopes
Are Fewer in Number and Fashionably Late [INFECTIOUS DISEASE AND HOST RESPONSE]: Class I HLA molecules mark infected cells for immune targeting by presenting pathogen-encoded peptides on the cell surface. Characterization of viral peptides unique to infected cells is important for understanding CD8+ T cell responses and for the development of T cell–based immunotherapies. Having previously reported a series of West Nile virus (WNV) epitopes that are naturally presented by HLA-A*02:01, in this study we generated TCR mimic (TCRm) mAbs to three of these peptide/HLA complexes—the imm... περισσότερα »
Helicobacter pylori {gamma}-Glutamyltranspeptidase Induces Tolerogenic Human Dendritic Cells
by Activation of Glutamate Receptors [INFECTIOUS DISEASE AND HOST RESPONSE]: *Helicobacter pylori* infection is characterized by chronic persistence of the bacterium. Different virulence factors, including *H. pylori* -glutamyltranspeptidase (gGT), have been reported to induce tolerogenicity by reprogramming dendritic cells (DCs). gGT is present in all bacterial isolates, indicating an important role for gGT in the course of infection. In the current study, we have analyzed the effect of *H. pylori* gGT on human DCs and the subsequent adaptive immune response. We show that glutam... περισσότερα »
Autoimmune Encephalomyelitis
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis [IMMUNOTHERAPY AND VACCINES]: Multiple sclerosis (MS) is a major neuroinflammatory demyelinating disease of the CNS. Current MS treatments, including immunomodulators and immunosuppressants, do not result in complete remission. Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells derived from dental pulp. Both SHED and SHED-conditioned medium (SHED-CM) exhibit immunomodulatory and regenerative activities and have the potenti... περισσότερα »
BET Inhibition Attenuates Helicobacter pylori-Induced Inflammatory Response
by Suppressing Inflammatory Gene Transcription and Enhancer Activation [IMMUNE REGULATION]: *Helicobacter pylori* infection causes chronic gastritis and peptic ulceration. *H. pylori*–initiated chronic gastritis is characterized by enhanced expression of many NF-B–regulated inflammatory cytokines. Brd4 has emerged as an important NF-B regulator and regulates the expression of many NF-B–dependent inflammatory genes. In this study, we demonstrated that Brd4 was not only actively involved in *H. pylori*–induced inflammatory gene mRNA transcription but also *H. pylori*–induced inflamm...περισσότερα »
IgM-mediated protection against pneumococcal infection.Age-Related Decline in Natural IgM Function
Diversification and Selection of the B-1a Cell Pool with Age [INNATE IMMUNITY AND INFLAMMATION]: *Streptococcus pneumoniae* is the most common cause of pneumonia, which claims the lives of people over the age of 65 y seven times more frequently than those aged 5–49 y. B-1a cells provide immediate and essential protection from *S. pneumoniae* through production of natural Ig, which has minimal insertion of N-region additions added by the enzyme TdT. In experiments with SCID mice infected with *S. pneumoniae*, we found passive transfer of IgG-depleted serum from aged (18–24 mo old) m... περισσότερα »
Resistance to Acute Macrophage Killing Promotes Airway Fitness
Resistance to Acute Macrophage Killing Promotes Staphylococcus aureus Strains [INFECTIOUS DISEASE AND HOST RESPONSE]: The incidence of methicillin-resistant *Staphylococcus aureus* (MRSA) pneumonia in otherwise healthy individuals is increasing. To investigate the mechanism underlying the epidemiological success of predominant community-associated (CA)-MRSA strains, we examined their fitness traits during the initial interaction between bacteria and the host occurring in the lower airway. Using a mouse respiratory infection model, we show that clinical isolates often responsible fo... περισσότερα »
Borrelia miyamotoi : Hard tick-borne relapsing fever (HTBRF)
Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi [INFECTIOUS DISEASE AND HOST RESPONSE]: *Borrelia miyamotoi* is a relapsing fever spirochete in *Ixodes* ticks that has been recently identified as a human pathogen causing hard tick-borne relapsing fever (HTBRF) across the Northern Hemisphere. No validated serologic test exists, and current serologic assays have low sensitivity in early HTBRF. To examine the humoral immune response against *B. miyamotoi*, we infected C3H/HeN mice with *B. miyamotoi* strain LB-2001 expressing variable small protei...περισσότερα »
Regulatory roles of mast cells in immune responses
Regulatory roles of mast cells in immune responses: AbstractMast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via FcεRI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.
Delayed hypersensitivity to bone cement
*Aseptic loosening of a total knee prosthesis caused by delayed hypersensitivity to bone cement* *via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology* *Publication date: Available online 6 May 2016Source:Annals of Allergy, Asthma & ImmunologyAuthor(s): Francisco Vega, Raphaelle Bazire, M. Teresa Belver, M. Victoria Mugica, Andres Urquia, Carlos Blanco* Use of antibiotic-containing *bone cement*. *WR Murray - Clinical orthopaedics and related research, 1984 - journals.lww.com* *... because of: (1) thermal stability; (2) wide antibacterial spec- trum; (3) extrem...περισσότερα »
Avoralstat, an Oral Plasma Kallikrein Inhibitor
Safety, Pharmacokinetics, and Pharmacodynamics of Avoralstat, an Oral Plasma Kallikrein Inhibitor: Phase 1 Study: Abstract Background Avoralstat is a potent small-molecule oral plasma kallikrein inhibitor under development for treatment of hereditary angioedema. This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of avoralstat. Methods This double-blind, placebo-controlled, ascending-dose cohort trial evaluated avoralstat single doses of 50, 125, 250, 500, and 1000 mg and multiple doses up to 2400 mg daily (100, 200, 400, and 800 mg e... περισσότερα »
Early life exposure to traffic-related air pollution
and lung function in adolescence assessed with impulse oscillometry via Allergy and Clinical Immunology Publication date: Available online 6 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Erica S. Schultz, Jenny. Hallberg, Per M. Gustafsson, Matteo Bottai, Tom Bellander, Anna Bergström, Inger Kull, Olena Gruzieva, Per Thunqvist, Göran Pershagen, Erik Melén TeaserExposure to air pollutants from local traffic during infancy was associated with increased peripheral conductive airway resistance in adolescence, particularly in those with concomitant asthma.
Occupational rhinitis and asthma due to ranitidine
Article in Press Aythamy Henriquez Santana, MDemail, Sandra Blanco Bermejo, MD, Javier Ruiz-Hornillos, MD, Marcela Valverde Monge, MD, Mar Fernandez Nieto, MD DOI: http://dx.doi.org/10.1016/j.anai.2016.04.011 Ranitidine is a histamine2-receptor antagonist that inhibits stomach acid production. It is widely used because of its few adverse effects. Being considered a safe drug, it is usually administered in emergency departments and during operations for the prevention of peptic ulcer. Few allergic reactions after intake of the drug have been reported in adults or children.1–6 Occupatio...περισσότερα »
Interaction between CD23 and IgE : The CD23 stalk region in IgE binding
Critical and direct involvement of via Allergy and Clinical Immunology *Source:*Journal of Allergy and Clinical Immunology Author(s): Regina Selb, Julia Eckl-Dorna, Teresa E. Twaroch, Christian Lupinek, Andrea Teufelberger, Gerhard Hofer, Margarete Focke-Tejkl, Barbara Gepp, Birgit Linhart, Heimo Breiteneder, Adolf Ellinger, Walter Keller, Kenneth H. Roux, Rudolf Valenta, Verena Niederberger BackgroundThe low-affinity receptor for IgE, FcεRII (CD23), contributes to allergic inflammation by allergen presentation to T cells, regulation of IgE responses and enhancing trans-epithelial al...περισσότερα »
Tumor Heterogeneity and Tumor Immunity
: A Chicken-and-Egg Problem via ScienceDirect Publication: Trends in Immunology Publication date: Available online 8 May 2016 *Source:*Trends in Immunology Author(s): Stefani Spranger The overall mutational burden of a tumor is considered to be a predictive marker for the success of checkpoint blockade therapy. A recent study by McGranahan et al. reframes this notion by showing that clonal expression of neoantigens by tumor cells, rather than overall mutational burden, determines the response to checkpoint blockade therapy.
Dendritic cells in inflammatory sinonasal diseases
Dendritic cells in inflammatory sinonasal diseases: Abstract Dendritic cells (DCs) are critical in linking the innate and adaptive immune responses, which have been implicated in the pathogenesis of many immune and inflammatory diseases as well as the development of tumors. The role of DCs in the pathophysiology of lung diseases has been widely studied. However, the phenotype, subset, and function of DCs in upper airways under physiological or pathological conditions remain largely undefined. Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are two important upper airway dis... περισσότερα »
Antibiotic use during pregnancy and asthma in preschool children
the influence of confounding: Abstract Background A recent study suggested that early-life intestinal microbiota may play an important role in the development of childhood asthma,indicating that antibiotics taken during early life or in late pregnancy may be associated with childhood asthma. Objective This study aims to assess the association between prenatal antibiotic use and asthma in preschool children using data from the prescription database IADB.nl. To assess the influence of potential confounding, we conducted both a case-sibling and a case-control study and compared the res... περισσότερα »
Increase in pollen sensitization
in Swedish adults and protective effect of keeping animals in childhood: Abstract Background To date, most studies of the “allergy epidemic” have been based on self-reported data. There is still limited knowledge on time trends in allergic sensitization, especially among adults. Objective To study allergic sensitization, its risk factors, and time trends in prevalence. Methods Within West Sweden Asthma Study (WSAS) a population-based sample of 788 adults (17-60y) underwent skin prick tests (SPT) for 11 aeroallergens 2009-2012. Specific IgE was analyzed in 750 of the participants. Th...περισσότερα »
Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity
Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity: [image: cover.gif?v=1&s=da614e72e3219d8335c602a9] In patients with juvenile idiopathic arthritis (JIA), increased release of IFN-γ and GM-CSF in cells infiltrating synovial tissue can be a potent driver of monocyte activation. Given the fundamental role of monocyte activation in remodeling the early phases of inflammatory responses, here we analyze the GM-CSF/IFN-γ-induced activity of human monocytes in such a situation in vitro and in vivo. Monocytes from health... περισσότερα »
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses: [image: cover.gif?v=1&s=da614e72e3219d8335c602a9] Intestinal macrophages (IMs) are uniquely programmed to tolerate exposure to bacteria without mounting potent inflammatory responses. The cytokine IL-10 maintains the macrophage anti-inflammatory response such that loss of IL-10 results in chronic intestinal inflammation. To investigate how IL-10-deficiency alters IM programming and bacterial tolerance, we studied changes in chromatin accessibility in response to bact... περισσότερα »
Clinician assessment of paranasal sinus pneumatization is correlated with total sinus volume
Clinician assessment of paranasal sinus pneumatization is correlated with total sinus volume: Background The Assessment of Pneumatization of the Paranasal Sinuses (APPS) score is a novel and validated instrument for comprehensively evaluating the pneumatization pattern of the sinuses. Previous studies on the relationship between sinus pneumatization and clinical parameters have been hindered by cumbersome volume analysis. The purpose of this study was to determine whether the APPS score correlates with total sinus volume. Methods Semiautomated 3-dimensional (3D) volume analysis of 2... περισσότερα »
Chronic spontaneous urticaria (CSU) : Infections were diagnosed in 29% of patients (syphilis, parasitosis, H. pylori, urinary infection, tuberculosis, hepatitis B and C); autoimmune diseases in 21% (thyroiditis, rheumatoid arthritis and antiphospholipid antibody syndrome); primary immunodeficiencies in 4% (IgA and IgG2 deficiencies); and chronic myeloid leukaemia in 1%.
A prospective ten-year follow-up of patients with chronic urticaria via Allergologia et Immunopathologia Author(s): P.C.L. Dionigi, M.C.S. Menezes, W.C.N. Forte BackgroundChronic urticaria can be the initial clinical presentation of a number of different diseases. The objective of the present study was to report the associated diseases during a ten-year clinical-laboratory follow-up in patients with an initial diagnosis of chronic spontaneous urticaria (CSU) of unknown cause.MethodsA prospective, longitudinal cohort study with a ten-year clinical-laboratory follow-up was conducted. ... περισσότερα »
Chronic urticaria
A prospective ten-year follow-up of patients with chronic urticaria via Allergologia et Immunopathologia Author(s): P.C.L. Dionigi, M.C.S. Menezes, W.C.N. Forte BackgroundChronic urticaria can be the initial clinical presentation of a number of different diseases. The objective of the present study was to report the associated diseases during a ten-year clinical-laboratory follow-up in patients with an initial diagnosis of chronic spontaneous urticaria (CSU) of unknown cause.MethodsA prospective, longitudinal cohort study with a ten-year clinical-laboratory follow-up was conducted. Pat... περισσότερα »
Endophthalmitis related to lemon allergy
in a heroin addict via Allergologia et Immunopathologia Author(s): A. Armentia, F. Pineda, B. Martin-Armentia, C. Ramos, F.J. Gil Martin, R. Palacios BackgroundHeroin and its contaminants may be an important source of allergens in young people. We present a case of severe endophthalmitis in a patient that also suffered from anaphylactoid symptoms (hypotension, urticaria, glottic oedema) whenever he ingested lemon.MethodsPrick tests with a battery of 42 aeroallergens including fruits and citrus fruits (orange, mandarin, grapefruit and lemon) and specific IgE to these allergens were ...περισσότερα »
Wheezing, rhinitis and dermatitis in preschoolers
Effect of foods and Mediterranean diet during pregnancy and first years of life on wheezing, rhinitis and dermatitis in preschoolers via Allergologia et Immunopathologia *Source:*Allergologia et Immunopathologia Author(s): J.A. Castro-Rodriguez, M. Ramirez-Hernandez, O. Padilla, R.M. Pacheco-Gonzalez, V. Pérez-Fernández, L. Garcia-Marcos BackgroundThere is a conflictive position if some foods and Mediterranean diet (MedDiet) consumed by the mother during pregnancy and by the child during the first years of life can be protective for current wheezing, rhinitis and dermatitis at prescho... περισσότερα »
Cow's milk protein antigen induced proctocolitis in infants
Educational clinical case series for pediatric allergy and immunology: Allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow's milk allergy Jennifer Maloney andAnna Nowak-Wegrzyn Keywords: allergic eosinophilic gastroenteritis;allergic proctocolitis;cow's milk allergy;eosinophilic gastroenteropathy;eosinophilic proctitis;eosinophlic proctocolitis;food protein-induced enterocolitis syndrome;food allergy;FPIES;protein-losing gastroenteropathy Cow's m...περισσότερα »
Fungal hypersensitivity and fungal microbiome dysbiosis are possible etiologies of chronic rhinosinusitis
Evaluation of Malassezia and Common Fungal Pathogens in Subtypes of Chronic Rhinosinusitis: Background Fungal hypersensitivity and fungal microbiome dysbiosis are possible etiologies of chronic rhinosinusitis. The sinus fungal microbiome is not well characterized; novel sinus-associated fungi, including *Malassezia*, have only recently been described. The goals for this study were to verify *Malassezia* as a dominant component of the sinus microbiome, to speciate sinus *Malassezia*, and to compare select fungal species in chronic rhinosinusitis (CRS) subtypes with known fungal asso... περισσότερα »
Malassezia and Common Fungal Pathogens in Subtypes of Chronic Rhinosinusitis
Evaluation of Background Fungal hypersensitivity and fungal microbiome dysbiosis are possible etiologies of chronic rhinosinusitis. The sinus fungal microbiome is not well characterized; novel sinus-associated fungi, including *Malassezia*, have only recently been described. The goals for this study were to verify *Malassezia* as a dominant component of the sinus microbiome, to speciate sinus *Malassezia*, and to compare select fungal species in chronic rhinosinusitis (CRS) subtypes with known fungal association to chronic rhinosinusitis with polyps (CRSwNP) and healthy controls. M...περισσότερα »
Shoulder morbidity after pectoralis major flap reconstruction
Shoulder morbidity after pectoralis major flap reconstruction: Abstract Background Donor site morbidity of pectoralis major pedicled flap (PMPF) is scarcely studied. Methods A cross-sectional study on patients who underwent reconstructive surgery with a PMPF at least 6 months before was performed. Patients with a similar type neck dissection on both sides and PMPF on one side (*n* = 9) were assigned to group 1; patients with neck dissection and PMPF (*n* = 26) were assigned to group 2; and neck dissection only (*n* = 47) were assigned to group 3. All 3 groups filled out a shoulder d...περισσότερα »
Can Helicobacter pylori be eradicated with high-dose proton pump inhibitor ?
in extensive metabolizers with the CYP2C19 genotypic polymorphism?: Proton pump inhibitors (PPI) metabolism and pharmacokinetics are regulated by cytochrome P450 enzymes in the liver. Cytochrome P450 2C19 (CYP2C19) polymorphism plays an import role in the metabolism of PPIs. The three possible genotypes for CYP2C19 each has a distinct effect on the pharmacodynamics of PPIs. Homozygote extensive metabolizers (HomEM) are the most frequent genotype and have two wild-types (non-mutant) (*1/*1) alleles. HomEM is associated with increased enzyme activity, which increases the rate of PPI... περισσότερα »
Helicobacter pylori infection in children
should it be carefully assessed?: The prevalence of H. pylori infection, mainly acquired during childhood and may be persisting throughout life, has been found high in developing countries; this high prevalence is related to low socioeconomic status. The persistence of bacterium exposure is related to gastritis and other severe complications including peptic ulcer, lymphoma MALT and gastric cancer, which are rarely present in the pediatric age due to a lower inflammatory and immunological response. Virulence factors, host gastric mucosal factors, and the natural environment of pati... περισσότερα »
The blood pressure (BP) fluctuation
Doubts and difficulties in studying blood pressure variability: The blood pressure (BP) fluctuation was first noticed in the 18th century. However, its clinical significance did not get attention until recent years. The increase in BP variability (BPV) is possibly more valuable than the increase in BP level for predicting damages in target organs. Moreover, attenuating BPV is more important than decreasing the BP level. However, the concept of BPV was not used in any related guideline for diagnosing, defining, and grading the risk of hypertension, which is due to the understanding ... περισσότερα »
The relationship between static posturography measures and specific cognitive domains in individuals with multiple sclerosis.
There are still limitations as to the understanding of the cognitive-postural control relationship in people with multiple sclerosis (PwMS). The aim of the current study' was to examine the relationship between cognition with measures of posturography in PwMS. The study was cross-sectional comprising 253 PwMS (162 women) with a mean age of 42.0 (SD=14.0). All participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains (Mindstreams; NeuroTrax) and static posturography tests (Zebris Medical GmbH). PwMS were divided into four levels of d...περισσότερα »
Does neighborhood fast-food outlet exposure amplify inequalities in diet and obesity? A cross-sectional study
American Journal of Clinical Nutrition from #Medicine via ola Kala on Inoreader http://ift.tt/1rJmMP0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sjuQqe via IFTTT
The use of capsule endoscopy in the emergency department as a triage of patients with GI bleeding
Gastrointestinal Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1R0Qcwh via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tam04g via IFTTT
Association between severity of obstructive sleep apnea and blood markers of liver injury
Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1rJmOGr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sjuPm9 via IFTTT
Dysphagia in patients with acute ischemic stroke: early dysphagia screening may reduce stroke-related pneumonia and improve stroke outcomes
Cerebrovascular Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1R0QeEt via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TalYt7 via IFTTT
Prevalence of overweight and obesity among children and adolescents with intellectual disabilities: a systematic review and meta-analysis
Obesity Reviews from #Medicine via ola Kala on Inoreader http://ift.tt/1rJmOpV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sjuPm7 via IFTTT
Applicability of hepatitis C virus RNA viral load thresholds for 8-week treatments in patients with chronic hepatitis C virus genotype 1 infection
Clinical Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1rJmOq5 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TalYcN via IFTTT
Management and outcomes of leaks after oesophagectomy
British Journal of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/1R0QcfZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sjuPm3 via IFTTT
The inter-rater reliability of the International Classification of Functioning, Disability and Health set for spinal cord injury nursing.
The International Classification of Functioning, Disability and Health (ICF) has potential to be used as a clinical assessment instrument directly. However, difficulty in operationalizing the ICF qualifiers has led to unsatisfactory inter-rater reliability of ICF instruments in previous studies. The ICF set for spinal cord injury (SCI) nursing contains a group of categories that can reflect the functioning of SCI patients from the perspective of nurses. The aim of this study was to explore the inter-rater reliability of the ICF set for SCI nursing. Detailed measuring guidelines were... περισσότερα »
The inter-rater reliability of the International Classification of Functioning, Disability and Health set for spinal cord injury nursing.
The International Classification of Functioning, Disability and Health (ICF) has potential to be used as a clinical assessment instrument directly. However, difficulty in operationalizing the ICF qualifiers has led to unsatisfactory inter-rater reliability of ICF instruments in previous studies. The ICF set for spinal cord injury (SCI) nursing contains a group of categories that can reflect the functioning of SCI patients from the perspective of nurses. The aim of this study was to explore the inter-rater reliability of the ICF set for SCI nursing. Detailed measuring guidelines were... περισσότερα »
Cognitive reserve and preinjury educational attainment: effects on outcome of community-based rehabilitation for longer-term individuals with acquired brain injury.
The cognitive reserve hypothesis has been proposed to account for the mismatch between brain pathology and its clinical expression. The aim of the current research was to explore, in a longitudinal data set, the effects of level of educational attainment before brain injury (cognitive reserve) and clinical factors on the level of rehabilitation-induced changes in disability and community integration. Participants in receipt of postacute rehabilitation were assessed at induction to the service and again at between 14 and 18 months of follow-up while still in service on changes in asp... περισσότερα »
The relationship between static posturography measures and specific cognitive domains in individuals with multiple sclerosis.
There are still limitations as to the understanding of the cognitive-postural control relationship in people with multiple sclerosis (PwMS). The aim of the current study' was to examine the relationship between cognition with measures of posturography in PwMS. The study was cross-sectional comprising 253 PwMS (162 women) with a mean age of 42.0 (SD=14.0). All participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains (Mindstreams; NeuroTrax) and static posturography tests (Zebris Medical GmbH). PwMS were divided into four levels of d...περισσότερα »
The Analgesic Effect of Obturator Nerve Block Added to a Femoral Triangle Block After Total Knee Arthroplasty: A Randomized Controlled Trial.
Background and Objectives: Total knee arthroplasty (TKA) is associated with severe pain, and effective analgesia is essential for the quality of postoperative care and ambulation. The analgesic effects of adding an obturator nerve block (ONB) to a femoral triangle block (FTB) after TKA have not been tested previously. We hypothesized that combined ONB and FTB will reduce opioid consumption and pain compared with those of a single FTB or local infiltration analgesia (LIA). Methods: Seventy-eight patients were randomized to combined ONB and FTB, single FTB, or LIA after primary unilat...περισσότερα »
Cognitive reserve and preinjury educational attainment: effects on outcome of community-based rehabilitation for longer-term individuals with acquired brain injury.
The cognitive reserve hypothesis has been proposed to account for the mismatch between brain pathology and its clinical expression. The aim of the current research was to explore, in a longitudinal data set, the effects of level of educational attainment before brain injury (cognitive reserve) and clinical factors on the level of rehabilitation-induced changes in disability and community integration. Participants in receipt of postacute rehabilitation were assessed at induction to the service and again at between 14 and 18 months of follow-up while still in service on changes in asp... περισσότερα »
Endophthalmitis related to lemon allergy
in a heroin addict via Allergologia et Immunopathologia Author(s): A. Armentia, F. Pineda, B. Martin-Armentia, C. Ramos, F.J. Gil Martin, R. Palacios BackgroundHeroin and its contaminants may be an important source of allergens in young people. We present a case of severe endophthalmitis in a patient that also suffered from anaphylactoid symptoms (hypotension, urticaria, glottic… Continue reading Endophthalmitis related to lemon allergy
Insights into the complex levels of regulation imposed on Escherichia coli DNA polymerase V
Publication date: Available online 13 May 2016 Source:DNA Repair Author(s): Myron F. Goodman, John P. McDonald, Malgorzata M. Jaszczur, Roger Woodgate It is now close to 40 years since the isolation of non-mutable umu/uvm strains of Escherichia coli and the realization that damage induced mutagenesis in E.coli is not a passive process. Early models of… Continue reading Insights into the complex levels of regulation imposed on Escherichia coli DNA polymerase V
Wheezing, rhinitis and dermatitis in preschoolers
Effect of foods and Mediterranean diet during pregnancy and first years of life on wheezing, rhinitis and dermatitis in preschoolers via Allergologia et Immunopathologia Source:Allergologia et Immunopathologia Author(s): J.A. Castro-Rodriguez, M. Ramirez-Hernandez, O. Padilla, R.M. Pacheco-Gonzalez, V. Pérez-Fernández, L. Garcia-Marcos BackgroundThere is a conflictive position if some foods and Mediterranean diet (MedDiet) consumed by the… Continue reading Wheezing, rhinitis and dermatitis in preschoolers
Involvement of Translesion Synthesis DNA Polymerases in DNA Interstrand Crosslink Repair
Publication date: Available online 13 May 2016 Source:DNA Repair Author(s): Upasana Roy, Orlando D. Schärer DNA interstrand crosslinks (ICLs) covalently join the two strands of a DNA duplex and block essential processes such as DNA replication and transcription. Several important anti-tumor drugs such as cisplatin and nitrogen mustards exert their cytotoxicity by forming ICLs. However,… Continue reading Involvement of Translesion Synthesis DNA Polymerases in DNA Interstrand Crosslink Repair
Cow’s milk protein antigen induced proctocolitis in infants
Educational clinical case series for pediatric allergy and immunology: Allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow’s milk allergy Jennifer Maloney andAnna Nowak-Wegrzyn Keywords: allergic eosinophilic gastroenteritis;allergic proctocolitis;cow’s milk allergy;eosinophilic gastroenteropathy;eosinophilic proctitis;eosinophlic proctocolitis;food protein-induced enterocolitis syndrome;food allergy;FPIES;protein-losing gastroenteropathy Cow’s mi...περισσότερα »
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy
in a mouse model of human BRAFV600-mutant melanoma via Cancer Immunology, Immunotherapy Abstract T cell checkpoint blockade with antibodies targeting programmed cell death (ligand)-1 (PD-1/PD-L1) and/or cytotoxic T lymphocyte-antigen 4 (CTLA-4) has improved therapy outcome in melanoma patients. However, a considerable proportion of patients does not benefit even from combined α-CTLA-4 and α-PD-1 therapy. We… Continue reading Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy
The Democratization of Gene Editing: Insights from site-specific cleavage and double-strand break repair
Publication date: Available online 12 May 2016 Source:DNA Repair Author(s): Maria Jasin, James E. Haber DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell death. Organisms have developed several pathways and have many factors devoted to repairing DSBs, which broadly occur by homologous recombination that… Continue reading The Democratization of Gene Editing: Insights from site-specific cleavage and double-strand break repair
Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/prim er or by perturbing the polymerase reaction
Publication date: Available online 12 May 2016 Source:DNA Repair Author(s): Yinbo Zhang, Andrey G. Baranovskiy, Emin T. Tahirov, Tahir H. Tahirov, Youri I. Pavlov DNA polymerases (pols) are sophisticated protein machines operating in the replication, repair and recombination of genetic material in the complex environment of the cell. DNA pol reactions require at least two… Continue reading Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/prim er or by perturbing the polymerase reaction
Early-life gut microbiome composition and milk allergy resolution
Early-life gut microbiome composition and milk allergy resolution via Allergy and Clinical Immunology Source:Journal of Allergy and Clinical Immunology Author(s): Supinda Bunyavanich, Nan Shen, Alexander Grishin, Robert Wood, Wesley Burks, Peter Dawson, Stacie M. Jones, Donald Leung, Hugh Sampson, Scott Sicherer, Jose C. Clemente BackgroundGut microbiota may play a role in the natural history of… Continue reading Early-life gut microbiome composition and milk allergy resolution
The Impact of Body Mass Index on the Thrombolytic Treatment of Acute Ischemic Stroke
Background: Body weight and body mass index (BMI) are regularly assessed factors in stroke patients for manifold reasons. However, their potential role specifically in intravenous thrombolysis has not been thoroughly examined. Methods: Data from 865 consecutive acute ischemic stroke patients treated with intravenous thrombolysis were analyzed. Patients were divided into different BMI categories (underweight, normal… Continue reading The Impact of Body Mass Index on the Thrombolytic Treatment of Acute Ischemic Stroke
The Analgesic Effect of Obturator Nerve Block Added to a Femoral Triangle Block After Total Knee Arthroplasty: A Randomized Controlled Trial.
Background and Objectives: Total knee arthroplasty (TKA) is associated with severe pain, and effective analgesia is essential for the quality of postoperative care and ambulation. The analgesic effects of adding an obturator nerve block (ONB) to a femoral triangle block (FTB) after TKA have not been tested previously. We hypothesized that combined ONB and FTB will reduce opioid consumption and pain compared with those of a single FTB or local infiltration analgesia (LIA). Methods: Seventy-eight patients were randomized to combined ONB and FTB, single FTB, or LIA after primary unilat...περισσότερα »
Fasting target for hyperglycaemia in pregnancy
Australian and New Zealand Journal of Obstetrics and Gynaecology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1rJxg0G via IFTTT
Motor vehicle crashes and dementia: a population-based study
Journal of the American Geriatrics Society from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TSxiMO via IFTTT
Serum metabonomics of mild acute pancreatitis
Journal of Clinical Laboratory Analysis from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1rJxepI via IFTTT
Evaluation of a physical activity behavior change program for individuals with a brain injury
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TSxiME via IFTTT
Does 'altitude training' increase exercise performance in elite athletes?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 47 δευτερόλεπτα
Athletes may use one of the various altitude training strategies to improve exercise performance. The scientific support for such strategies is however not as sound as one would perhaps imagine. The question addressed in this review is whether altitude training should be recommended to elite athletes or not. This article is protected by copyright. All rights reserved from Physiology via xlomafota13 on Inoreader http://ift.tt/27jgQg1 via IFTTT
DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DELIVERY SYSTEM OF LOSARTAN POTASSIUM
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 47 δευτερόλεπτα
2016-05-13T03-38-16Z *Source:* Indo American Journal of Pharmaceutical Research Shaikh Siraj*, Molvi Khurshid .I. The objective of the study was to design and develop Gastroretentive dosage form for Losartan potassium using floating bioadhesive tablet approach with Polyox Wsr 1105 & HPMC K 4M polymers & sodium bicarbonate & citric acid as gas generating agents to reduce floating lag time. Optimization study was carried out by using 32 factorial design to prepare formulations. Vit E is added as a antioxidant for development of this gastroretentive dosage form of Losartan potassium by... περισσότερα »
Competition between hydrogen bonding and protein aggregation in neuronal-like cells under exposure to 50 Hz magnetic field
10.1080/09553002.2016.1175679<br>Emanuele Calabrò from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1Wu91Rr via IFTTT
Toxins, Vol. 8, Pages 149: Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
[image: ag] Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis, and its structural isomer symmetric dimethylarginine (SDMA) are uremic toxins accumulating in chronic kidney disease (CKD) patients. The objective of this study was to develop and validate a robust UPLC-MS/MS method for the simultaneous determination of ADMA and SDMA in human serum. Chromatographic separation after butyl ester derivatization was achieved on an Acquity UPLC BEH C18 column, followed by tandem mass spectrometric detection. After validation, the applicability of the ...περισσότερα »
Polymers, Vol. 8, Pages 163: The Effect of Lithium Iodide to the Properties of Carboxymethyl κ-Carrageenan/Carboxymethyl Cellulose Polymer Electrolyte and Dye-Sensitized Solar Cell Performance
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
[image: ag] This study was undertaken to investigate the solid biopolymer electrolytes based on a carboxymethyl κ-carrageenan/carboxymethyl cellulose blend complexed with lithium iodide of various weight ratios. The complexation of the doping salt with the polymer blend was confirmed by Fourier transform infrared spectroscopy. Ionic conductivity of the film was determined by impedance spectroscopy in the frequency range of 10 Hz to 4 MHz and in the temperature range of 303–338 K. The ionic conductivity increased with the increase in lithium iodide concentration as well as temperatu...περισσότερα »
Separations, Vol. 3, Pages 14: Method for the Determination of Benzene Metabolite t,t-Muconic Acid in Urine by HPLC-UV with an Ion Exclusion Column
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
[image: ag] The benzene metabolite trans,trans-muconic acid (tt-MA) is widely used as a biological indicator of exposure to this xenobiotic. An analytical method was developed and validated for the determination of urinary tt-MA using solid phase extraction onto a Strata SAX cartridge. The analysis was performed by HPLC with an Aminex HPX-87H ion exclusion column and a UV diode array detector. The sample preparation conditions were optimized using a 24−1 factorial design. Comparison of the slopes of standard analytical curves prepared in aqueous solution and urine showed that the ...περισσότερα »
Broad Bandgap D–A Copolymer Based on Bithiazole Acceptor Unit for Application in High-Performance Polymer Solar Cells with Lower Fullerene Content
A new broad bandgap and 2D-conjugated D-A copolymer, *PBDTBTz-T*, based on bithienyl-benzodithiophene donor unit and bithiazole (BTz) acceptor unit, is designed and synthesized for the application as donor material in polymer solar cells (PSCs). The polymer possesses highly coplanar and crystalline structure with a higher hole mobility and lower HOMO energy level which is beneficial to achieve higher open circuit voltage (*V*oc) of the PSCs with the polymer as donor. The PSCs based on *PBDTBTz-T*:PC71BM blend film with a lower PC71BM content of 40% demonstrate a power conversion ...περισσότερα »
Self-sorting regioisomers through hierarchical organization of hydrogen-bonded rosettes
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03419E, Communication Keisuke Aratsu, Deepak D Prabhu, Hidetaka Iwawaki, Xu Lin, Mitsuaki Yamauchi, Takashi Karatsu, Shiki Yagai The self-assembly of two regioisomeric hydrogen-bonding naphthalenes was studied in mixed states in different polarity solvents. The regioisomers co-assemble to form heteromeric rosettes in chloroform. Upon injecting this solution into... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1ZM8xU8 via... περισσότερα »
Revisiting the segmental organization of the human spinal cord
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract In classic anatomic atlases, the spinal cord is standardly represented in its anatomical form with symmetrically emerging anterior and posterior roots, which at the level of the intervertebral foramen combine into the spinal nerves. The parts of the cord delimited by the boundaries of the roots are called segments or myelomeres. Associated with their […]
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Musculoskeletal modelling has become a valuable tool with which to understand how neural, muscular, skeletal and other tissues are integrated to produce movement. Most musculoskeletal modelling work has to date focused on humans or their close relatives, with few examples of quadrupedal animal limb models. A musculoskeletal model of the mouse hindlimb could have […]
Support your denture patients
British Dental Journal 220, 492 (2016). doi:10.1038/sj.bdj.2016.349 from #Dental via xlomafota13 on Inoreader http://ift.tt/1ZMfdSo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Global consumption of sugar
British Dental Journal 220, 435 (2016). doi:10.1038/sj.bdj.2016.322 from #Dental via xlomafota13 on Inoreader http://ift.tt/1sjFU6x via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
NSD1 duplication in Silver-Russell syndrome (SRS): Molecular karyotyping in patients with SRS features
Abstract Silver-Russell syndrome (SRS) is a growth retardation syndrome characterized by intrauterine and postnatal growth retardation, relative macrocephaly and protruding forehead, body asymmetry and feeding difficulties. Nearly 50% of cases show a hypomethylation in 11p15.5, in 10% maternal uniparental disomy of chromosome 7 is present. A significant number of patients with SRS features also exhibit chromosomal aberrations. We analysed 43 individuals referred for SRS genetic testing by molecular karyotyping. Pathogenic variants could be detected in five of them, including a *NS... περισσότερα »
mRNA-based Detection of Rare CFTR Mutations Improves Genetic Diagnosis of Cystic Fibrosis in Populations with High Genetic Heterogeneity
Abstract Even with advent of Next Generation Sequencing complete sequencing of large disease-associated genes and intronic regions is economically not feasible. This is the case of CFTR, the gene responsible for Cystic Fibrosis (CF). Yet, to confirm a CF diagnosis, proof of CFTR dysfunction needs to be obtained, namely by identification of two disease-causing mutations. Moreover, with the advent of mutation-based therapies, genotyping is an essential tool for CF disease management. There is however, still an unmet need to genotype CF patients by fast, comprehensive and cost-effecti...περισσότερα »
Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: A population-based, case-control study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
BMC Genomics from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1R0QeVb via IFTTT
