Specificity of the Human Frequency Following Response for Carrier and Modulation Frequency Assessed Using Adaptation
Specificity of the Human Frequency Following Response for Carrier and Modulation Frequency Assessed Using Adaptation: AbstractThe frequency following response (FFR) is a scalp-recorded measure of phase-locked brainstem activity to stimulus-related periodicities. Three experiments investigated the specificity of the FFR for carrier and modulation frequency using adaptation. FFR waveforms evoked by alternating-polarity stimuli were averaged for each polarity and added, to enhance envelope, or subtracted, to enhance temporal fine structure information. The first experiment investigate...περισσότερα »
Repeated Moderate Noise Exposure
Repeated Moderate Noise Exposure in the Rat—an Early Adulthood Noise Exposure Model: AbstractIn this study, we investigated the effects of varying intensity levels of repeated moderate noise exposures on hearing. The aim was to define an appropriate intensity level that could be repeated several times without giving rise to a permanent hearing loss, and thus establish a model for early adulthood moderate noise exposure in rats. Female Sprague-Dawley rats were exposed to broadband noise for 90 min, with a 50 % duty cycle at levels of 101, 104, 107, or 110 dB sound pressure level (SP...περισσότερα »
Nonlinear Vibration Response Measured at Umbo and Stapes in the Rabbit Middle ear
Nonlinear Vibration Response Measured at Umbo and Stapes in the Rabbit Middle ear: AbstractUsing laser vibrometry and a stimulation and signal analysis method based on multisines, we have measured the response and the nonlinearities in the vibration of the rabbit middle ear at the level of the umbo and the stapes. With our method, we were able to detect and quantify nonlinearities starting at sound pressure levels of 93-dB SPL. The current results show that no significant additional nonlinearity is generated as the vibration signal is passed through the middle ear chain. Nonlineari... περισσότερα »
Temporal Resolution of the Normal Ear in Listeners with Unilateral Hearing Impairment
Temporal Resolution of the Normal Ear in Listeners with Unilateral Hearing Impairment: AbstractUnilateral hearing loss (UHL) leads to an imbalanced input to the brain and results in cortical reorganization. In listeners with unilateral impairments, while the perceptual deficits associated with the impaired ear are well documented, less is known regarding the auditory processing in the unimpaired, clinically normal ear. It is commonly accepted that perceptual consequences are unlikely to occur in the normal ear for listeners with UHL. This study investigated whether the temporal res... περισσότερα »
Finite-Element Modelling of the Response of the Gerbil Middle Ear to Sound
Finite-Element Modelling of the Response of the Gerbil Middle Ear to Sound: AbstractWe present a finite-element model of the gerbil middle ear that, using a set of baseline parameters based primarily on a priori estimates from the literature, generates responses that are comparable with responses we measured in vivo using multi-point vibrometry and with those measured by other groups. We investigated the similarity of numerous features (umbo, pars-flaccida and pars-tensa displacement magnitudes, the resonance frequency and break-up frequency, etc.) in the experimental responses with...περισσότερα »
Concurrent Acoustic Activation of the Medial Olivocochlear System Modifies the After-Effects of Intense Low-Frequency Sound on the Human Inner Ear
Concurrent Acoustic Activation of the Medial Olivocochlear System Modifies the After-Effects of Intense Low-Frequency Sound on the Human Inner Ear: Abstract>Human hearing is rather insensitive for very low frequencies (i.e. below 100 Hz). Despite this insensitivity, low-frequency sound can cause oscillating changes of cochlear gain in inner ear regions processing even much higher frequencies. These alterations outlast the duration of the low-frequency stimulation by several minutes, for which the term ‘bounce phenomenon’ has been coined. Previously, we have shown that the bounce can...περισσότερα »
Channel Interaction and Current Level Affect Across-Electrode Integration of Interaural Time Differences in Bilateral Cochlear-Implant Listeners
Channel Interaction and Current Level Affect Across-Electrode Integration of Interaural Time Differences in Bilateral Cochlear-Implant Listeners: AbstractSensitivity to interaural time differences (ITDs) is important for sound localization. Normal-hearing listeners benefit from across-frequency processing, as seen with improved ITD thresholds when consistent ITD cues are presented over a range of frequency channels compared with when ITD information is only presented in a single frequency channel. This study aimed to clarify whether cochlear-implant (CI) listeners can make use of s... περισσότερα »
Effects of Spectral Degradation on Attentional Modulation of Cortical Auditory Responses to Continuous Speech
Effects of Spectral Degradation on Attentional Modulation of Cortical Auditory Responses to Continuous Speech: AbstractThis study investigates the effect of spectral degradation on cortical speech encoding in complex auditory scenes. Young normal-hearing listeners were simultaneously presented with two speech streams and were instructed to attend to only one of them. The speech mixtures were subjected to noise-channel vocoding to preserve the temporal envelope and degrade the spectral information of speech. Each subject was tested with five spectral resolution conditions (unprocess...περισσότερα »
Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation
Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation: ABSTRACTImplanted vestibular neurostimulators are effective in driving slow phase eye movements in monkeys and humans. Furthermore, increases in slow phase velocity and electrically evoked compound action potential (vECAP) amplitudes occur with increasing current amplitude of electrical stimulation. In intact monkeys, protracted intermittent stimulation continues to produce robust behavioral responses and preserved vECAPs. In lesioned monkeys, shorter duration stud... περισσότερα »
Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2
Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2: AbstractSLC44A2 (solute carrier 44a2), also known as CTL2 (choline transporter-like protein 2), is expressed in many supporting cell types in the cochlea and is implicated in hair cell survival and antibody-induced hearing loss. In mice with the mixed C57BL/6-129 background, homozygous deletion of *Slc44a2* exons 3–10 (*Slc44a2* Δ/Δ) resulted in high-frequency hearing loss and hair cell death. To reduce effects associated with age-related hearing l... περισσότερα »
Tuning to Binaural Cues in Human Auditory Cortex
Tuning to Binaural Cues in Human Auditory Cortex: AbstractInteraural level and time differences (ILD and ITD), the primary binaural cues for sound localization in azimuth, are known to modulate the tuned responses of neurons in mammalian auditory cortex (AC). The majority of these neurons respond best to cue values that favor the contralateral ear, such that contralateral bias is evident in the overall population response and thereby expected in population-level functional imaging data. Human neuroimaging studies, however, have not consistently found contralaterally biased binaural... περισσότερα »
Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants
Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants: AbstractA wealth of knowledge about different types of neural responses to electrical stimulation has been developed over the past 100 years. However, the exact forms of neural response properties can vary across different types of neurons. In this review, we survey four stimulus-response phenomena that in recent years are thought to be relevant for cochlear implant stimulation of spiral ganglion neurons (SGNs): refractoriness, facilitation, accommodation, and spike rate adaptation. Of these fou... περισσότερα »
Excitation Patterns of Standard and Steered Partial Tripolar Stimuli in Cochlear Implants
Excitation Patterns of Standard and Steered Partial Tripolar Stimuli in Cochlear Implants: AbstractCurrent steering in partial tripolar (pTP) mode has been shown to improve pitch perception and spectral resolution with cochlear implants (CIs). In this mode, a fraction (*σ*) of the main electrode current is returned within the cochlea and steered between the basal and apical flanking electrodes (with a proportion of *α* and 1 − *α*, respectively). Pitch generally decreases when *α* increases from 0 to 1, although the salience of pitch change varies across CI users. This study aimed ... περισσότερα »
Pitch and Phoneme Perception in Cochlear Implant Users
Correlations Between Pitch and Phoneme Perception in Cochlear Implant Users and Their Normal Hearing Peers Abstract This study examined correlations between pitch and phoneme perception for nine cochlear implant users and nine normal hearing listeners. Pure tone frequency discrimination thresholds were measured for frequencies of 500, 1000, and 2000 Hz. Complex tone fundamental frequency (F0) discrimination thresholds were measured for F0s of 110, 220, and 440 Hz. The effects of amplitude and frequency roving were measured under the rationale that individuals who are robust to such p...περισσότερα »
Diagnosis of Cochlear Neuropathy with Envelope Following Responses
Towards a Diagnosis of Cochlear Neuropathy with Envelope Following Responses Abstract Listeners with normal audiometric thresholds can still have suprathreshold deficits, for example, in the ability to discriminate sounds in complex acoustic scenes. One likely source of these deficits is cochlear neuropathy, a loss of auditory nerve (AN) fibers without hair cell damage, which can occur due to both aging and moderate acoustic overexposure. Since neuropathy can affect up to 50 % of AN fibers, its impact on suprathreshold hearing is likely profound, but progress is hindered by lack of a ... περισσότερα »
Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms
Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms in Guinea Pigs, Chinchillas, and Simulations Abstract According to coherent reflection theory (CRT), stimulus frequency otoacoustic emissions (SFOAEs) arise from cochlear irregularities coherently reflecting energy from basilar membrane motion within the traveling-wave peak. This reflected energy arrives in the ear canal predominantly with a single delay at each frequency. However, data from humans and animals indicate that (1) SFOAEs can have multiple delay components, (2) low-frequency SFOAE delays are too sh... περισσότερα »
Pitch Discrimination
Pitch Discrimination in Musicians and Non-Musicians: Effects of Harmonic Resolvability and Processing Effort Abstract Musicians typically show enhanced pitch discrimination abilities compared to non-musicians. The present study investigated this perceptual enhancement behaviorally and objectively for resolved and unresolved complex tones to clarify whether the enhanced performance in musicians can be ascribed to increased peripheral frequency selectivity and/or to a different processing effort in performing the task. In a first experiment, pitch discrimination thresholds were obtaine...περισσότερα »
Excitation Patterns of Standard and Steered Partial Tripolar Stimuli in Cochlear Implants
Excitation Patterns of Standard and Steered Partial Tripolar Stimuli in Cochlear Implants Abstract Current steering in partial tripolar (pTP) mode has been shown to improve pitch perception and spectral resolution with cochlear implants (CIs). In this mode, a fraction (*σ*) of the main electrode current is returned within the cochlea and steered between the basal and apical flanking electrodes (with a proportion of *α* and 1 − *α*, respectively). Pitch generally decreases when *α* increases from 0 to 1, although the salience of pitch change varies across CI users. This study aimed to... περισσότερα »
Selective Inner Hair Cell Dysfunction Impairs Hearing-in-Noise in the Absence of Outer Hair Cell Loss
Selective Inner Hair Cell Dysfunction in Chinchillas Impairs Hearing-in-Noise in the Absence of Outer Hair Cell Loss Abstract Poorer hearing in the presence of background noise is a significant problem for the hearing impaired. Ototoxic drugs, ageing, and noise exposure can damage the sensory hair cells of the inner ear that are essential for normal hearing sensitivity. The relationship between outer hair cell (OHC) loss and progressively poorer hearing sensitivity in quiet or in competing background noise is supported by a number of human and animal studies. In contrast, the effect ... περισσότερα »
Survival in Carcinoma of the Minor Salivary Gland
Survival in Carcinoma of the Minor Salivary Gland: This population-based study uses SEER data to assess 5- and 10-year survival rates among US patients with carcinoma of the minor salivary gland. AbstractSend to: Otolaryngol Head Neck Surg. doi: 10.1016/j.otohns.2010.02.033. Survival in oral cavity minor salivary gland carcinoma. Kakarala K1, Bhattacharyya N. Author information 1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Abstract OBJECTIVE: To describe the epidemiology and comparative survival for minor salivary gland cancer of the ... περισσότερα »
Increased Spontaneous Otoacoustic Emissions in Detached Tectorial Membrane
Increased Spontaneous Otoacoustic Emissions in Mice with a Detached Tectorial Membrane Abstract Mutations in genes encoding tectorial membrane (TM) proteins are a significant cause of human hereditary hearing loss (Hildebrand et al. 2011), and several mouse models have been developed to study the functional significance of this accessory structure in the mammalian cochlea. In this study, we use otoacoustic emissions (OAE), signals obtained from the ear canal that provide a measure of cochlear function, to characterize a mouse in which the TM is detached from the spiral limbus due to ...περισσότερα »
Journal of the Association for Research in Otolaryngology
Increased Spontaneous Otoacoustic Emissions in Mice with a Detached Tectorial Membrane Abstract Mutations in genes encoding tectorial membrane (TM) proteins are a significant cause of human hereditary hearing loss (Hildebrand et al. 2011), and several mouse models have been developed to study the functional significance of this accessory structure in the mammalian cochlea. In this study, we use otoacoustic emissions (OAE), signals obtained from the ear canal that provide a measure of cochlear function, to characterize a mouse in which the TM is detached from the spiral limbus due to ...περισσότερα »
International Journal of Otolaryngology
Elicitation of the Acoustic Change Complex to Long-Duration Speech Stimuli in Four-Month-Old Infants The acoustic change complex (ACC) is an auditory-evoked potential elicited to changes within an ongoing stimulus that indicates discrimination at the level of the auditory cortex. Only a few studies to date have attempted to record ACCs in young infants. The purpose of the present study was to investigate the elicitation of ACCs to long-duration speech stimuli in English-learning 4-month-old infants. ACCs were elicited to consonant contrasts made up of two concatenated speech tokens. ... περισσότερα »
Sleep Medicine Reviews
Sleep propensity in psychiatric hypersomnolence: a systematic review and meta-analysis of multiple sleep latency test findings Hypersomnolence plays a sizeable role in the course and morbidity of psychiatric disorders. Current sleep medicine nosology is reliant on the multiple sleep latency test (MSLT) to segregate hypersomnolence associated with psychiatric disorders from other central nervous system causes. However, the evidence base regarding sleep propensity in psychiatric hypersomnolence as measured by the MSLT has not been systematically evaluated, which is vital to clarify the...περισσότερα »
Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea
Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea: This meta-analysis assesses postoperative improvement in the apnea-hypopnea index and/or respiratory disturbance index in a population of patients undergoing maxillomandibular advancement for obstructive sleep apnea. AbstractSend to: JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2678. [Epub ahead of print] Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea: A Meta-analysis. Zaghi S1, Holty JC2, Certal V3, Abdullatif J4, Guilleminault C5, Powell NB6, Riley RW6, Camacho M7. ... περισσότερα »
Outcomes for Congenital Aural Atresia and Hypoplasia Repair
Outcomes for Congenital Aural Atresia and Hypoplasia Repair: This case series uses medical record review data to describe clinical outcomes for patients undergoing surgical repair of congenital aural atresia and hypoplasia. JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2713. [Epub ahead of print] Surgical and Audiometric Outcomes for Repair of Congenital Aural Atresia and Hypoplasia. Moss WJ1, Lin HW2, Cueva RA3. Author information 1Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego. 2Department of Otolaryngology-Head and Neck ... περισσότερα »
Reconstruction of the Mandibular Without Tracheostomy
Reconstruction of the Mandibular Without Tracheostomy: This medical record review identifies potential factors in successful microvascular mandibular reconstruction without an elective tracheotomy. Otolaryngol Head Neck Surg. doi: 10.1177/0194599814556625. Epub 2014 Nov 10. Microvascular reconstruction of segmental mandibular defects without tracheostomy. Moubayed SP1, Barker DA2, Razfar A2, Nabili V2, Blackwell KE2. Author information 1Division of Otolaryngology-Head and Neck Surgery, Université de Montréal, Montreal, Canada sp.moubayed@gmail.com. 2Department of Head and Neck... περισσότερα »
Rigid Esophagoscopy for Head and Neck Cancer Staging
Rigid Esophagoscopy for Head and Neck Cancer Staging: This study examines the current role of rigid esophagoscopy in evaluating patients with head and neck squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2815. [Epub ahead of print] Rigid Esophagoscopy for Head and Neck Cancer Staging and the Incidence of Synchronous Esophageal Malignant Neoplasms. McGarey PO Jr1, O'Rourke AK2, Owen SR3, Shonka DC Jr1, Reibel JF1, Levine PA1, Jameson MJ1. Author information 1Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolary... περισσότερα »
Safety and efficacy of phage therapy via the intravenous route
Increasing development of antimicrobial resistance is driving a resurgence in interest in phage therapy: the use of bacteriophages to treat bacterial infections. As the lytic action of bacteriophages is unaffected by the antibiotic resistance status of their bacterial target, it is thought that phage therapy may have considerable potential in the treatment of a wide range of topical and localized infections. As yet this interest has not extended to intravenous (IV) use, which is surprising given that the historical record shows that phages are likely to be safe and effective when ... περισσότερα »
Cellular and molecular engineering of yeast Saccharomyces cerevisiae for advanced biobutanol production
Butanol is an attractive alternative energy fuel owing to several advantages over ethanol. Among the microbial hosts for biobutanol production, yeast *Saccharomyces cerevisiae* has a great potential as a microbial host due to its powerful genetic tools, a history of successful industrial use, and its inherent tolerance to higher alcohols. Butanol production by *S. cerevisiae* was first attempted by transferring the 1-butanol-producing metabolic pathway from native microorganisms or using the endogenous Ehrlich pathway for isobutanol synthesis. Utilizing alternative enzymes with hi... περισσότερα »
Corrigendum to “Correction of the hypertrophic conchal bowl without cartilage excision” [J Plastic Reconstr Aesthet Surg 67 (2014) 1393–1396]
The authors regret that an error has been found in this article. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1JNHNzF via IFTTT
Trachea pressures in laryngectomised patients
Physiology and prospects of bimanual tracheoesophageal brass instrument play.: [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *Physiology and prospects of bimanual tracheoesophageal brass instrument play.* Acta Otorhinolaryngol Ital. 1. [image: Fig. 3.] Fig. 3. From: Physiology and prospects of bimanual tracheoesophageal brass instrument play. Comparison of pharyngoesophageal segment during voicing and during tenor horn playing. F.J.M. HILGERS, et al. Acta Otorhinolaryngol Ital. 2015 June;35(3):202-207. CitationFull text 2. [image: Fig. 5.] Fig. 5. From: Physiology and prospec... περισσότερα »
Another Paradox? The Life Satisfaction of Older Hispanic Immigrants in the United States
Objective: To investigate disparities in life satisfaction among older Hispanic immigrants in the United States relative to their native-born Hispanic and non-Hispanic White counterparts, and to identify factors associated with such disparities. Method: Cross-sectional data from 9,798 individuals age 60 and above from the Health and Retirement Study (HRS) were used to estimate ordinary least… Continue reading Another Paradox? The Life Satisfaction of Older Hispanic Immigrants in the United States
Endogenous GLP-1 and GLP-1 analogue alter CNS responses to palatable food consumption
Glucagon-like peptide-1 (GLP-1) affects appetite, supposedly mediated via the central nervous system (CNS). We investigate if modulation of CNS responses to palatable food consumption may be a mechanism by which GLP-1 contributes to the central regulation of feeding. Using functional-MRI, we determined effects of endogenous GLP-1 and treatment with the GLP-1 analogue liraglutide on CNS… Continue reading Endogenous GLP-1 and GLP-1 analogue alter CNS responses to palatable food consumption
Androgen receptor (AR) in cardiovascular diseases
Cardiovascular diseases (CVDs) are still the highest leading cause of death worldwide. Several risk factors have been linked to CVDs, including smoking, diabetes, hyperlipidemia, and gender. Sex hormones, especially the androgen and its receptor, androgen receptor (AR), have been linked to many diseases with gender difference. Here, we summarize androgen/AR effects on CVDs, including hypertension,… Continue reading Androgen receptor (AR) in cardiovascular diseases
Modern Therapies for Idiopathic Inflammatory Myopathies (IIMs): Role of Biologics
Abstract Despite the lack of placebo-controlled trials, glucocorticoids are considered the mainstay of initial treatment for idiopathic inflammatory myopathy (IIMs) and myositis-associated ILD (MA-ILD). Glucocorticoid-sparing agents are often given concomitantly with other immunosuppressive agents, particularly in patients with moderate or severe disease. As treatment of refractory cases of idiopathic inflammatory myopathies has been challenging, there… Continue reading Modern Therapies for Idiopathic Inflammatory Myopathies (IIMs): Role of Biologics
Should we cluster patients or symptoms? The myth of symptom clusters based on ‘depression, insomnia, pain and ‘depression, fatigue, pain
Context ‘Depression, fatigue, pain’ (DFP) and ‘depression, insomnia, pain’ (DIP) symptom clusters (SCs) have been proposed in cancer. These symptoms are common and co-occur, that is, they constitute clusters of patients rather than symptoms. Objectives The following research questions were addressed: (1) What is the frequency of co-occurrence of two symptom groups (DFP and DIP)… Continue reading Should we cluster patients or symptoms? The myth of symptom clusters based on ‘depression, insomnia, pain and ‘depression, fatigue, pain
A fatal outcome of pica
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q21W4q via IFTTT
Universal newborn hearing screening in Umbria region, Italy
Publication date: Available online 14 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Egisto Molini, Lucia Calzolaro, Ruggero Lapenna, Giampietro Ricci ObjectiveIn Italy, universal newborn hearing screening (UNHS) was first introduced in some regions from 1997. Umbria Region has launched a UNHS program in all hospitals, which has been implemented throughout the region since July… Continue reading Universal newborn hearing screening in Umbria region, Italy
Midline nasofrontal dermoids in children: A review of 29 cases managed at Mansoura University Hospitals
Publication date: Available online 14 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Ahmed Musaad Abd El-fattah, Ahmed Naguib, Hossam El-Sisi, Elsharawy Kamal, Ali Tawfik ObjectivesNasal dermoids are congenital anomalies constituting 3.7–12.6% of dermoids in the head and neck. Most of lesions are superficial but there is always a risk that it may end blindly… Continue reading Midline nasofrontal dermoids in children: A review of 29 cases managed at Mansoura University Hospitals
Diseases, Vol. 4, Pages 3: Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis
As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone… Continue reading Diseases, Vol. 4, Pages 3: Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis
From culture to creativity and the creative economy: A new agenda for cultural economics
Publication date: Available online 14 January 2016 Source:City, Culture and Society Author(s): Xavier Greffe Cultural Economy – which analyses the production, distribution and reception of symbolic contents – is dominated by the economics of welfare. This way of thinking marginalized the role of creativity and closed the corresponding analysis in a very static framework. Face… Continue reading From culture to creativity and the creative economy: A new agenda for cultural economics
Batteries, Vol. 2, Pages 1: Electrochemical Study of Na2Fe1−xMnxP2O7 (x = 0, 0.25, 0.5, 0.75, 1) as Cathode Material for Rechargeable Na-Ion Batteries
Sodium-ion batteries (SIBs) are considered a good choice for post-lithium devices. Transition metal sodium pyrophosphates are among the most interesting cathode materials for SIBs. Here we study the electrochemical properties of the system Na2Fe1−xMnxP2O7 (x = 0, 0.25, 0.5, 0.75, 1). By means of cyclic voltammetry (CV) and galvanostatic experiments, we confirm that pure Fe and Fe-rich compounds are promising for application in sodium batteries, whereas Mn-rich samples are less satisfactory, at least in case of solid-state reaction recipes and standard slurry preparations. Proper c... περισσότερα »
18F-FDG PET/CT in the Management of Squamous Cell Carcinoma of the Head and Neck and Thyroid Carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Clinical Role of Andrew Quon 1 , Nancy J. Fischbein 2 , I. Ross McDougall 1 , Quynh-Thu Le 3 , Billy W. Loo Jr. 3 , Harlan Pinto 4 and Michael J. Kaplan 5 –Author Affiliations 1Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, Stanford, California; 2Division of Neuroradiology, Department of […]
Registers of the Swedish total population and their use in medical research
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Abstract The primary aim of the Swedish national population registration system is to obtain data that (1) reflect the composition, relationship and identities of the Swedish population and (2) can be used as the basis for correct decisions and measures by government and other regulatory authorities. For this purpose, Sweden has established two population registers: […]
Universal newborn hearing screening in Umbria region, Italy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Egisto Molini, Lucia Calzolaro, Ruggero Lapenna, Giampietro Ricci ObjectiveIn Italy, universal newborn hearing screening (UNHS) was first introduced in some regions from 1997. Umbria Region has launched a UNHS program in all hospitals, which has been implemented throughout the region since July […]
Benefit from Bevacizumab and CCNU in Recurrent GBM Patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
The results from the randomized phase II BELOB trial provided evidence for a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A, when added to CCNU chemotherapy in patients with recurrent glioblastoma (GBM). In this study, we performed gene expression profiling (DASL and RNA-seq) of formalin-fixed, paraffin-embedded tumor material from participants of […]
Editorial Board/Reviewing Committee
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Qa9i7S via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3Pqo5 via IFTTT
Identification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Alterations in chromatin accessibility independent of DNA methylation can affect cancer-related gene expression, but are often overlooked in conventional epigenomic profiling approaches. In this study, we describe a cost-effective and computationally simple assay called AcceSssIble to simultaneously interrogate DNA methylation and chromatin accessibility alterations in primary human clear cell renal cell carcinomas (ccRCC). Our study […]
Servier’s pipeline in oncology: moving from research to patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PvnJyP via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3Pp3w via IFTTT
Midline nasofrontal dermoids in children: A review of 29 cases managed at Mansoura University Hospitals
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Ahmed Musaad Abd El-fattah, Ahmed Naguib, Hossam El-Sisi, Elsharawy Kamal, Ali Tawfik ObjectivesNasal dermoids are congenital anomalies constituting 3.7–12.6% of dermoids in the head and neck. Most of lesions are superficial but there is always a risk that it may end blindly […]
AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Epithelial-to-mesenchymal transition (EMT) is an essential physiological process that promotes cancer cell migration, invasion, and metastasis. Several lines of evidence from both cellular and genetic studies suggest that AKT1/PKBα, but not AKT2 or AKT3, serves as a negative regulator of EMT and breast cancer metastasis. However, the underlying mechanism by which AKT1 suppresses EMT remains […]
Preclinical anticancer efficacy of BET bromodomain inhibitors is determined by the apoptotic response
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Small molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic […]
Temporo-mandibular joint chondrosarcoma
Temporo-mandibular joint chondrosarcoma: Case report and review of the literature.: [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *Temporo-mandibular joint chondrosarcoma: Case report and review of the literature.* Acta Otorhinolaryngol Ital. 1. [image: Fig. 5.] Fig. 5. From: Temporo-mandibular joint chondrosarcoma: Case report and review of the literature. The final surgical wound. C. GIORGIONE, et al. Acta Otorhinolaryngol Ital. 2015 June;35(3):208-211. CitationFull text 2. [image: Fig. 3.] Fig. 3. From: Temporo-mandibular joint chondrosarcoma: Case report and review of the l... περισσότερα »
Editorial Board/Reviewing Committee
from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1Qa9i7S via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Neurosensorial damage with unilateral hearing loss and/or tinnitus and dizziness : Cerebellar Angioreticuloma
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *Audiological findings in a case of cerebellar angioreticuloma.* Acta Otorhinolaryngol Ital. 2015 Jun;35(3):212-4 Authors: Serra A, DI Mauro P, Cocuzza S, Chiaramonte I, Maiolino L Abstract The aetiology of neurosensorial damage with unilateral hearing loss and/or tinnitus and dizziness can often be difficult to determine because they may be caused wide variety of pathologic processes and a variety of diagnostic tests are needed in initial evaluation. In this paper, the authors describe, the techniques and indications of neuroimaging for... περισσότερα »
18F-FDG PET/CT in the Management of Squamous Cell Carcinoma of the Head and Neck and Thyroid Carcinoma
Clinical Role of 1. Andrew Quon 1 , 2. Nancy J. Fischbein 2 , 3. I. Ross McDougall 1 , 4. Quynh-Thu Le 3 , 5. Billy W. Loo Jr. 3 , 6. Harlan Pinto 4 and 7. Michael J. Kaplan 5 -Author Affiliations 1. 1Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, Stanford, California; 2Division of Neuroradiology, Department of Radiology, Stanford University Medical Center, Stanford, California; 3Department of Radiation Oncology, Stanford University Medical Center, Stanford, California; 4Division of Oncology, Dep...περισσότερα »
Use of FDG-PET/CT in Oropharyngeal Squamous Cell Carcinoma
Use of FDG-PET/CT in Oropharyngeal Squamous Cell Carcinoma: This review summarizes the use of 18F-fludeoxyglucose–positron emission tomography/computed tomography in staging, therapy planning, evaluating therapy response, detecting recurrence, and predicting prognosis in patients with oropharyngeal squamous cell carcinoma. Acta Otorhinolaryngol Ital. PMCID: PMC3631810 Role of 18F-FDG PET-CT in head and neck squamous cell carcinoma P. CASTALDI,1,* L. LECCISOTTI,1,* F. BUSSU, F. MICCICHÈ,3 and V. RUFINI1 1 Institute of Nuclear Medicine 2 Institute of Otolaryngology 3 Institute of Ra... περισσότερα »
Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Patrick J. Grohar, Suntae Kim, Guillermo O. Rangel Rivera, Nirmalya Sen, Sara Haddock, Matt L. Harlow, Nichole K. Maloney, Jack Zhu, Maura O’Neill, Tamara L. Jones, Konrad Huppi, Magdalena Grandin, Kristen Gehlhaus, Carleen A. Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. […]
The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Shuisong Cao, Xiaomin Su, Benhua Zeng, Hui Yan, Yugang Huang, Enlin Wang, Huan Yun, Yuan Zhang, Feifei Liu, Wenxia Li, Hong Wei, Yongzhe Che, Rongcun Yang Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and […]
PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Frédéric Boal, Andrea Puhar, Jean-Marie Xuereb, Oksana Kunduzova, Philippe J. Sansonetti, Bernard Payrastre, Hélène Tronchère Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion […]
Information Coding through Adaptive Gating of Synchronized Thalamic Bursting
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Clarissa J. Whitmire, Christian Waiblinger, Cornelius Schwarz, Garrett B. Stanley It has been posited that the regulation of burst/tonic firing in the thalamus could function as a mechanism for controlling not only how much but what kind of information is conveyed to downstream cortical targets. […]
Formation of the Cortical Subventricular Zone Requires MDGA1-Mediated Aggregation of Basal Progenitors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Carlos G. Perez-Garcia, Dennis D.M. O’Leary The subventricular zone (SVZ) provides a specialized neurogenic microenvironment for proliferation and aggregation of basal progenitors (BPs). Our study reveals a mechanism for the aggregation of BPs within the SVZ required for their proliferation and generation of cortical layer […]
LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Cell Reports Author(s): Ji Won Um, Tae-Yong Choi, Hyeyeon Kang, Yi Sul Cho, Gayoung Choii, Pavel Uvarov, Dongseok Park, Daun Jeong, Sangmin Jeon, Dongmin Lee, Hyun Kim, Seung-Hee Lee, Yong-Chul Bae, Se-Young Choi, Matti S. Airaksinen, Jaewon Ko The four members of the LRRTM family (LRRTM1-4) are postsynaptic […]
Surgeon Volume and Outcomes and Cost Savings Following Thyroidectomy
Surgeon Volume and Outcomes and Cost Savings Following Thyroidectomy: In this cross-sectional analysis of Nationwide Inpatient Sample thyroidectomy data, procedures performed by higher-volume surgeons were associated with fewer complications and lower cost. JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2503. [Epub ahead of print] Association of Surgeon Volume With Outcomes and Cost Savings Following Thyroidectomy: A National Forecast. Al-Qurayshi Z1, Robins R2, Hauch A1, Randolph GW3, Kandil E1. Author information 1Department of Surgery, Tulane University School o... περισσότερα »
Dysphagia Following Airway Reconstruction in Adults
Dysphagia Following Airway Reconstruction in Adults: In this review of the medical records of adults who underwent open airway reconstruction, all patients returned to preoperative diet, but those without stents had shorter duration of dysphagia symptoms than those with stents. AbstractSend to: JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2562. [Epub ahead of print] Dysphagia Following Airway Reconstruction in Adults. Lennon CJ1, Gelbard A1, Bartow C2, Garrett CG1, Netterville JL1, Wootten CT1. Author information 1Department of Otolaryngology, Vanderbilt Univers... περισσότερα »
Social Impact of Facial Infantile Hemangiomas in Preteen Children
Social Impact of Facial Infantile Hemangiomas in Preteen Children: This survey study found that preteen children with involuted, untreated facial infantile facial hemangiomas (IHs) have higher Social Anxiety domain scores in new situations and decreased Social Initiative domain scores compared with children who receive treatment for facial IH. AbstractSend to: JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2597. [Epub ahead of print] Social Impact of Facial Infantile Hemangiomas in Preteen Children. Costa VA1, Haimowitz R1, Cheng YI2, Wang J2, Silverman RA3, Bauman ...περισσότερα »
A new approach for the modelling of chestnut wood photo-degradation monitored by different spectroscopic techniques
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract The aim of this work is to study the colour and chemical modifications of the surfaces in chestnut wood samples as a consequence of irradiating in a controlled environment. The changes were investigated by a new analytical approach by combining traditional techniques such as reflectance spectrophotometry in the visible range and Fourier transform infrared […]
Soil concentration profiles and diffusion and emission of nitrous oxide influenced by the application of biochar in a rice-wheat annual rotation system
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Field experiments were carried out to determine biochar effects on nitrous oxide (N2O) concentration profiles, diffusion, and emissions in paddy soil under rice-wheat annual rotation in southeastern China. An in situ soil gas device was adapted to measure N2O concentrations at depths of 7, 15, 30, and 50 cm. Five treatments were installed as […]
Inhibition effects of high calcium concentration on anaerobic biological treatment of MSW leachate
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract With the increasing use of municipal solid waste incineration (MSWI) and more stringent limits on landfilling of organic waste, more MSWI bottom ash is being landfilled, and the proportion of inorganic wastes in landfills is increasing, causing the increased Ca concentrations in landfill leachate. In this research, the inhibition effect of Ca concentration on […]
The removal of illicit drugs and morphine in two waste water treatment plants (WWTPs) under tropical conditions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract The consumption of drugs of abuse has been recently investigated in Martinique using the back-calculation approach, also called the “sewage epidemiology” method. Results demonstrated a very high consumption considering the international data. Wastewater treatment plants (WWTPs) are located just behind the Martinique island shoreline, and effluents could impact the vulnerable corals and marine seagrass […]
An ecological risk assessment of heavy metal contamination in the surface sediments of Bosten Lake, northwest China
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Bosten Lake, a typical rump lake in an oasis in northwest China, was chosen to evaluate the distribution, sources, pollution status, and potential ecological risk of heavy metals. Sediment samples were collected from the lake, and results showed that the values of the eight heavy metals all fell within the Second Soil National Standard, […]
Polycyclic aromatic hydrocarbon-contaminated soils: bioaugmentation of autochthonous bacteria and toxicological assessment of the bioremediation process by means of Vicia faba L.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Two bacterial strains, Achromobacter sp. (ACH01) and Sphingomonas sp. (SPH01), were isolated from a heavily polycyclic aromatic hydrocarbon (PAH)-contaminated soil (5431.3 ± 102.3 ppm) for their capacity to use a mixture of anthracene, pyrene, phenanthrene and fluorene as sole carbon sources for growth and for the capacity to produce biosurfactants. The two strains were exploited for […]
Degradation of benzophenone-3 by the ozonation in aqueous solution: kinetics, intermediates and toxicity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Benzophenone-3 (BP-3) is a popular ultraviolet absorbing chemical and has an adverse impact on aquatic ecosystems and human health. We determined the reaction kinetic constants of BP-3 and its de-proton pattern reacting with the molecular ozone or hydroxyl radical (·OH) for the first time. The obtained constant of the molecular ozone reacting with BP-3 […]
A bioluminescent arsenite biosensor designed for inline water analyzer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Whole-cell biosensors based on the reporter gene system can offer rapid detection of trace levels of organic or metallic compounds in water. They are well characterized in laboratory conditions, but their transfer into technological devices for the surveillance of water networks remains at a conceptual level. The development of a semi-autonomous inline water analyzer […]
The size distribution of organic carbon in headwater streams in the Amazon basin
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Despite the strong representativeness of streams in the Amazon basin, their role in the accumulation of coarse particulate organic carbon (CPOC), fine particulate organic carbon (FPOC), and dissolved organic carbon (DOC) in transport, an important energy source in these environments, is poorly known. It is known that the arboreal vegetation in the Amazon basin […]
Electrochemical destruction of trans -cinnamic acid by advanced oxidation processes: kinetics, mineralization, and degradation route
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Acidic solutions of trans-cinnamic acid at pH 3.0 have been comparatively treated by anodic oxidation with electrogenerated H2O2 (AO-H2O2), electro-Fenton (EF), and photoelectro-Fenton (PEF). The electrolytic experiments were carried out with a boron-doped diamond (BDD)/air-diffusion cell. The substrate was very slowly abated by AO-H2O2 because of its low reaction rate with oxidizing •OH produced […]
Patterns of Hospital Use and Regionalization of Inpatient Pediatric Adenotonsillectomy.
Patterns of Hospital Use and Regionalization of Inpatient Pediatric Adenotonsillectomy.: [image: http:--archotol.jamanetwork.com-images-P] *Patterns of Hospital Use and Regionalization of Inpatient Pediatric Adenotonsillectomy.* JAMA Otolaryngol Head Neck Surg. Authors: Shay S, Shapiro NL, Bhattacharyya N Abstract Importance: Pediatric adenotonsillectomy is one of the most frequently performed procedures in the United States. Whereas several studies have focused on tonsillectomy techniques and outcomes, little is known about the overall changes in the distribution of care. Variat... περισσότερα »
Prevalence and Risk Factors of Chronic Rhinosinusitus,Allergic Rhinitis,and Nasal Septal Deviation
Prevalence and Risk Factors of Chronic Rhinosinusitus, Allergic Rhinitis, and Nasal Septal Deviation: Results of the Korean National Health and Nutrition Survey 2008-2012.: [image: http:--archotol.jamanetwork.com-images-P] *Prevalence and Risk Factors of Chronic Rhinosinusitus, Allergic Rhinitis, and Nasal Septal Deviation: Results of the Korean National Health and Nutrition Survey 2008-2012.* JAMA Otolaryngol Head Neck Surg. 2016 Jan 7;:1-7 Authors: Ahn JC, Kim JW, Lee CH, Rhee CS Abstract Importance: Chronic rhinosinusitis (CRS), allergic rhinitis (AR), and nasal septal deviat... περισσότερα »
Classification of Cholesteatoma According to Growth Patterns.
Classification of Cholesteatoma According to Growth Patterns.: [image: http:--archotol.jamanetwork.com-images-P] *Classification of Cholesteatoma According to Growth Patterns.* JAMA Otolaryngol Head Neck Surg. 2016 Jan 7;:1-5 Authors: Rosito LS, Netto LF, Teixeira AR, da Costa SS Abstract Importance: Several classifications of cholesteatoma exist, but there are controversies about their clinical application. Objective: To classify cholesteatomas and describe the prevalence of the subtypes. Design, Setting, and Participants: A cross-sectional comparative study of 414 ears in 356 ... περισσότερα »
Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis.
Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis.: [image: http:--archotol.jamanetwork.com-images-P] *Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis.* JAMA Otolaryngol Head Neck Surg. 2016 Jan 7;:1-6 Authors: Kurata N, Schachern PA, Paparella MM, Cureoglu S Abstract Importance: Age-related changes in cochlear vessel wall thickness in human temporal bones have not been described previously. Objectives: To compare thickness of the spiral modiolar artery and strial capillaries and to investigate... περισσότερα »
JAMA Otolaryngology-Head & Neck Surgery
JAMA Otolaryngology-Head & Neck Surgery. *JAMA Otolaryngology-Head & Neck Surgery.* JAMA Otolaryngol Head Neck Surg. 2016 Jan 7;:7 Authors: PMID: 26747827 [PubMed - as supplied by publisher] Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis. *Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis.* JAMA Otolaryngol Head Neck Surg. 2016 Jan 7;:1-6 Authors: Kurata N, Schachern PA, Paparella MM, Cureoglu S Abstract Importance: Age-related changes in cochlear vessel wall thickness in human temporal bones have not ... περισσότερα »
Assessment of Vocal Fold Function Using Transcutaneous Laryngeal Ultrasonography
Assessment of Vocal Fold Function Using Transcutaneous Laryngeal Ultrasonography by Kandil E, Deniwar A, Noureldine SI, et al. via JAMA Otolaryngology–Head & Neck Surgery Current Issue This study evaluates the sensitivity, specificity, and accuracy of transcutaneous laryngeal ultrasonography and flexible fiberoptic laryngoscopy for the assessment of vocal fold function in nonoverweight and overweight/obese patients undergoing thyroid and parathyroid surgery. JAMA Otolaryngol Head Neck Surg. doi: 10.1001/jamaoto.2015.2795. [Epub ahead of print] Assessment of Vocal Fold Function Using T...περισσότερα »
Completely absent (anosmia) or highly reduced (hyposmia)
Kallmann syndrome From Wikipedia, the free encyclopedia Kallmann syndrome[image: GNRH1 structure.png] The structure of GNRH1 (from PDB: 1YY1) Classification and external resourcesSpecialtyendocrinologyICD-10E23.0ICD- 9-CM253.4 DiseasesDB7091eMedicinemed/1216med/1342MeSHD017436 *Kallmann syndrome* is a genetic condition where the primary symptom is a failure to start puberty or a failure to fully complete it. It occurs in both males and females and has the additional symptoms of hypogonadism and almost invariably infertility. Kallmann syndrome also features the additional symptom of an... περισσότερα »
Surgical Salvage of Head and Neck Squamous Cell Carcinoma
Original Investigation Selection of Ideal Candidates for Surgical Salvage of Head and Neck Squamous Cell Carcinoma Effect of the Charlson–Age Comorbidity Index and Oncologic Characteristics on 1-Year Survival and Hospital Course JeeHong Kim, BS1; Seungwon Kim, MD2; William G. Albergotti, MD2; Phillip A. Choi, BS1; Daniel James Kaplan, BA1; Shira Abberbock, MS3; Jonas T. Johnson, MD2; Neil Gildener-Leapman, MD4 [-] Author Affiliations 1University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 2Department of Otolaryngology–Head and Neck Surgery, University of Pittsburgh Medic... περισσότερα »
Caution Against Overinvestigation of Small Thyroid Nodules
Caution Against Overinvestigation of Small Thyroid Nodules: *In Reply* We would like to thank the radiologists who wrote a letter in response to our recently published article. Their primary concern was that our finding of smaller thyroid nodules (TNs) having a relatively increased likelihood of malignancy regardless of Bethesda classification could be misconstrued by readers and, in so doing, perpetuate the overinvestigation of TN. This concern is indeed valid, as this is a true phenomenon within our field.
Fluorescence Visualization–Guided Surgery for Early-Stage Oral Cancer
*Original Investigation | January 14, 2016* FREE ONLINE FIRST *Catherine F. Poh, DDS, PhD1,2,3,4; Donald W. Anderson, MD1,2,3; J. Scott Durham, MD1,2,3; Jiahua Chen, PhD1,2,3; Kenneth W. Berean, MD1,2,3; Calum E. MacAulay, PhD4; Miriam P. Rosin, PhD4,5* *1Division of Otolaryngology–Head and Neck Surgery, Department of Oral Biological and Medical Science, University of British Columbia, Vancouver, Canada 2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada 3Department of Statistics, University of British Columbia, Vancouver, Canada 4Int...περισσότερα »
Pediatric vs Adult Nasopharyngeal Carcinoma
Original Investigation | January 14, 2016 Factors Associated With Mortality in Pediatric vs Adult Nasopharyngeal Carcinoma ONLINE FIRST Morgan K. Richards, MD, MPH1,2; John P. Dahl, MD, PhD, MBA3; Kenneth Gow, MD 2; Adam B. Goldin, MD, MPH2; John Doski, MD4; Melanie Goldfarb, MD5; Jed Nuchtern, MD6; Monica Langer, MD7; Elizabeth A. Beierle, MD8; Sanjeev Vasudevan, MD6; Douglas S. Hawkins, MD9; Sanjay R. Parikh, MD3 [-] Author Affiliations 1Department of Surgery, University of Washington, Seattle 2Division of Pediatric General and Thoracic Surgery, Department of General and Thoracic Surg... περισσότερα »
Unknown Primary Squamous Cell Carcinoma of the Head and Neck
Original Investigation | January 14, 2016 Changes in Unknown Primary Squamous Cell Carcinoma of the Head and Neck at Initial Presentation in the Era of Human PapillomavirusONLINE FIRST Kevin Motz, MD1; Jesse R. Qualliotine, BS1; Eleni Rettig, MD1; Jeremy D. Richmon, MD1; David W. Eisele, MD1; Carole Fakhry, MD, MPH1 *Importance* The presence of human papillomavirus (HPV) in unknown primary squamous cell carcinoma (UPSCC) of the head and neck at initial presentation focuses the investigation for the primary tumor on the oropharynx. The trends, frequency, and detection rate of UPSCCs h... περισσότερα »
Facial Swelling in an Infant
Clinical Challenge | January 14, 2016RADIOLOGY QUIZ ONLINE FIRST Adrian Kay France, MD1; Joshua Joseph Kain, MD2; Anand Gourishankar, MD1 [-] Author Affiliations 1University of Texas Medical School at Houston, Department of Pediatrics, Houston 2University of Texas Medical School at Houston, Medical School, Houston *JAMA Otolaryngol Head Neck Surg*. Published online January 14, 2016. doi:10.1001/jamaoto.2015.3197 Case Discussion Figures References Comments An infant presented with a 1-month history of recurrent, right-sided facial swelling with fever and nonbilious, nonbloody vomiting; ... περισσότερα »
The American Thyroid Association Guidelines on Voice Assessment
Viewpoint | January 14, 2016 —Have We Done Enough? *JAMA Otolaryngol Head Neck Surg*. Published online January 14, 2016. doi:10.1001/jamaoto.2015.3222 Article References Comments This Viewpoint examines new American Thyroid Association guidelines that recommend a preoperative voice assessment for all patients undergoing thyroid surgery and suggests that the guidelines are deficient in their selective approach to preoperative and postoperative laryngeal examination. For the first time since their inception, the American Thyroid Association (ATA) guidelines include a recommendation ... περισσότερα »
Ein nicht juckender Fleck am Bauch
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Hautrötung Eine 54-jährige Patientin bemerkte morgens bei Duschen eine umschriebene Hautveränderung am Bauch. Die Stelle war leicht erhaben, juckte und schuppte nicht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RJtoaN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Genetic polymorphisms associated with heart failure: A literature review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. Methods Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015. Results Eighty-two articles covering 29 genes and 39 polymorphisms were identified. Conclusion Genetic association […]
Tracheobronchomegaly associated with laryngo-tracheal amyloidosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article in Press Tracheobronchomegaly associated with laryngo-tracheal amyloidosis: First case report Kazuo Adachi , Toshiro Umezaki , Shizuo Komune Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan DOI: http://ift.tt/1SfeecQ Abstract Tracheobronchomegaly (TBM) is a rare enlargement of the tracheal cartilage, also known as Mounier-Kuhn syndrome (MKS). Here, […]
Corrigendum to “Correction of the hypertrophic conchal bowl without cartilage excision” J Plastic Reconstr Aesthet Surg 67 (2014) 1393–1396
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The authors regret that an error has been found in this article. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JNHNzF via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UTvaDV via IFTTT
Ischemia-modified albumin, brain natriuretic peptide, and growth differentiation factor-15 levels in patients with nasal polyps
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article in Press Kamran Sari , Zeliha Kapusuz Gencer , Huseyin Ede , Ayse Yesim Gocmen , Yunus Kantekin DOI: http://ift.tt/1nmTzqW Abstract Objective Nasal polyps (NP) are a chronic inflammatory disease of the nasal mucosa; their etiology is suspected to involve oxidative stress. Growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and ischemia-modified albumin (IMA) […]
Crosshatching incision technique in septoplasty
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Crosshatching incision technique in septoplasty: Experimental outcomes under actual surgical settings: In previous experiments, the crosshatching incision has been shown to be an effective method for the correction of cartilaginous deviations. Although the settings of the experiments were different from that of septoplasty, the crosshatching incision has been considered a useful method for septoplasty. Therefore, […]
Pretreatment screening for distant metastases in the Dutch head and neck centers: 10 years later
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract To evaluate the current practice and change in practice concerning screening for distant metastases in head and neck squamous cell carcinoma patients, we performed a survey with the same questionnaire as 10 years ago among the eight centers of the Dutch Head and Neck Society treating head and neck cancer in The Netherlands. Factors […]
Laryngology litigation in the United States: Thirty years in review
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ConclusionAn awareness of laryngology malpractice litigation has the potential to provide better patient care and help laryngologists avoid potential risks for litigation. The factors determining legal responsibility in laryngology cases underscore the importance of close communication with anesthesiologists and careful evaluation of hoarseness in all patients regardless of risk factors. Level of EvidenceN/A. Laryngoscope, 2015 […]
Congenital nasal neuroglial heterotopia and encephaloceles: An update on current evaluation and management
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ConclusionNasal neuroglial heterotopia and encephaloceles are very rare lesions that require multidisciplinary evaluation and management. At our institution, there has been a shift to magnetic resonance imaging alone for the evaluation of NGH to avoid radiation exposure. Endoscopic extracranial resection is feasible for most intranasal and mixed NGH without an increase in operative time, residual […]
Fundamental Frequency of Crying in Two-month-old Boys and Girls: Do Sex Hormones During Mini-puberty Mediate Differences?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
To evaluate whether the puberty-like sex hormone surge during the first months of life (mini-puberty) affects fundamental frequency (fo) in infant crying as one would derive from hormone influences on voice in adults. from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PveZIO via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader […]
Vertical Phase Difference and Glottal Efficiency in Musical Theater and Opera Singers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The objectives of this study were to (1) determine the relationship between vertical phase difference (VPD) and glottal efficiency (GE) in singers and (2) to compare VPD and GE between musical theater and opera singing styles. from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PveWNc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros […]
Ein nicht juckender Fleck am Bauch
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Hautrötung Eine 54-jährige Patientin bemerkte morgens bei Duschen eine umschriebene Hautveränderung am Bauch. Die Stelle war leicht erhaben, juckte und schuppte nicht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RJtoaN via IFTTT
Crosshatching incision technique in septoplasty
: Experimental outcomes under actual surgical settings via Auris Nasus Larynx Publication date: Available online 14 January 2016 *Source:*Auris Nasus Larynx Author(s): Sung Jae Heo, Jung Soo Kim ObjectiveIn previous experiments, the crosshatching incision has been shown to be an effective method for the correction of cartilaginous deviations. Although the settings of the experiments were different from that of septoplasty, the crosshatching incision has been considered a useful method for septoplasty. Therefore, we attempted to determine the efficacy of the crosshatching incision techn...περισσότερα »
Midline nasofrontal dermoids in children
Article in Press : A review of 29 cases managed at Mansoura University Hospitals Ahmed Musaad Abd El-fattah[image: correspondence][image: email][image: email] , Ahmed Naguib , Hossam El-Sisi , Elsharawy Kamal , Ali Tawfik DOI: http://dx.doi.org/10.1016/j.ijporl.2016.01.005 - AbstractObjectives Nasal dermoids are congenital anomalies constituting 3.7–12.6% of dermoids in the head and neck. Most of lesions are superficial but there is always a risk that it may end blindly within the deep structures of the nose or extend intracranially. Complete excision, regardless of extension...περισσότερα »
Nasopharyngeal granulomatous mass after radiotherapy
Article in Press Nasopharyngeal granulomatous mass after radiotherapy for nasopharyngeal carcinoma Lu Yang1 , Houyong Li1 , Huan Wang , Huankang Zhang , Shuyi Wang , Allison N. Fry , Wade W. Han , Dehui Wang[image: correspondence][image: email] 1These authors contributed equally to this article. DOI: http://dx.doi.org/10.1016/j.anl.2015.10.005 AbstractObjective To evaluate the diagnosis, management and nasal endoscopic surgical outcome of nasopharyngeal granulomatous mass in post-radiation nasopharyngeal carcinoma (NPC) patients. Materials and methods A total of 23 cases of granu... περισσότερα »
Clinical application of vestibular evoked myogenic potential (VEMP)
Article in Press Toshihisa Murofushi[image: correspondence][image: email] Department of Otolaryngology, Teikyo University School of Medicine, Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki 213-8507, Japan DOI: http://dx.doi.org/10.1016/j.anl.2015.12.006 - Abstract The author reviewed clinical aspects of vestibular evoked myogenic potentials (VEMPs). Now two types of VEMPs are available. The first one is cervical VEMP, which is recorded in the sternocleidomastoid muscle and predominantly reflects sacculo-collic reflex. The other is ocular VEMP, which is usually re...περισσότερα »
Tracheobronchomegaly associated with laryngo-tracheal amyloidosis
Article in Press Tracheobronchomegaly associated with laryngo-tracheal amyloidosis: First case report Kazuo Adachi[image: correspondence][image: email] , Toshiro Umezaki , Shizuo Komune Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan DOI: http://dx.doi.org/10.1016/j.anl.2015.12.008 - Abstract Tracheobronchomegaly (TBM) is a rare enlargement of the tracheal cartilage, also known as Mounier-Kuhn syndrome (MKS). Here, we describe an unusual case of acquired TBM in an adult, caused by amy... περισσότερα »
Ischemia-modified albumin, brain natriuretic peptide, and growth differentiation factor-15 levels in patients with nasal polyps
Article in Press Kamran Sari[image: correspondence][image: email] , Zeliha Kapusuz Gencer[image: email] , Huseyin Ede[image: email] , Ayse Yesim Gocmen[image: email] , Yunus Kantekin[image: email] DOI: http://dx.doi.org/10.1016/j.anl.2015.12.009 - AbstractObjective Nasal polyps (NP) are a chronic inflammatory disease of the nasal mucosa; their etiology is suspected to involve oxidative stress. Growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and ischemia-modified albumin (IMA) are biomarkers used especially in the early diagnosis and follow-up of ca... περισσότερα »
Crosshatching incision technique in septoplasty
Crosshatching incision technique in septoplasty: Experimental outcomes under actual surgical settings: In previous experiments, the crosshatching incision has been shown to be an effective method for the correction of cartilaginous deviations. Although the settings of the experiments were different from that of septoplasty, the crosshatching incision has been considered a useful method for septoplasty. Therefore, we attempted to determine the efficacy of the crosshatching incision technique under actual septoplasty surgical settings. AbstractObjective In previous experiments, the... περισσότερα »
Heterogeneity of intrahepatic fat distribution determined by 18 F-FDG PET and CT
Abstract Objectives Hepatic steatosis is common but less is known of the heterogeneity of hepatic fat distribution and its clinical significance. Our objective was to measure the regional variabilities within the liver of standardised uptake values (SUV) as potential markers of hepatic fat distribution heterogeneity. Methods Twenty-four patients having routine, clinically indicated PET/CT with 18F-FDG and a wide range of fatty liver severity were selected. Maximum SUV (SUVmax), average SUV (SUVave), both calculated using lean body mass, and CT density were measured in 12 × 2-cm d... περισσότερα »
Cyclin D1 and DNA Damage Sensing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Therapy resistance and poor outcome in prostate cancer is associated with increased expression of cyclin D1. Androgens promote DNA double-strand break repair to reduce DNA damage, and cyclin D1 was also shown to enhance DNA damage repair (DDR). In this study, we investigated the significance of cyclin D1 in androgen-induced DDR using established prostate cancer […]
IL21 Signaling in Anti-ErbB2 Therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The HER2/ErbB2 monoclonal antibody (mAb) trastuzumab is combined with chemotherapy as a standard-of-care for newly diagnosed HER2+ breast cancer patients, but some patients treated with this combination therapy experience early relapse. Our analysis of data from a clinical trial evaluating the efficacy of chemotherapy plus/minus trastuzumab suggested that the magnitude of trastuzumab benefit on distant […]
KIR and HLA in Skin Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Natural killer (NK)–cell phenotype is partially mediated through binding of killer-cell immunoglobulin-like receptors (KIR) with HLA class I ligands. The KIR gene family is highly polymorphic and not well captured by standard genome-wide association study approaches. Here, we tested the hypothesis that variations in KIR gene content combined with HLA class I ligand status is […]
PRC2, Th1 Chemokines, and Tumor Immunity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Infiltration of tumors with effector T cells is positively associated with therapeutic efficacy and patient survival. However, the mechanisms underlying effector T-cell trafficking to the tumor microenvironment remain poorly understood in patients with colon cancer. The polycomb repressive complex 2 (PRC2) is involved in cancer progression, but the regulation of tumor immunity by epigenetic mechanisms […]
PD-1-Mediated Paralysis of DCs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The PD-1:PD-L1 immune signaling axis mediates suppression of T-cell–dependent tumor immunity. PD-1 expression was recently found to be upregulated on tumor-infiltrating murine (CD11c+CD11b+CD8−CD209a+) and human (CD1c+CD19−) myeloid dendritic cells (TIDC), an innate immune cell type also implicated in immune escape. However, there is little knowledge concerning how PD-1 regulates innate immune cells. In this study, […]
MYC and Pten Cooperate to Induce Prostate Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall number of such changes is increased in metastases. Chromosome 10q23 deletions, encompassing PTEN, and amplification of 8q24, harboring MYC, are frequently […]
Guanylin Suppression by Calorie-Induced ER Stress in Obesity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In […]
HBXIP and LSD1 Scaffolded by Hotair Activate c-Myc
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
c-Myc is regarded as a transcription factor, but the basis for its function remains unclear. Here, we define a long noncoding RNA (lncRNA)/protein complex that mediates the transcriptional activation by c-Myc in breast cancer cells. Among 388 c-Myc target genes in human MCF-7 breast cancer cells, we found that their promoters could be occupied by […]
BRAF/PI3K{beta}/IGF1R Inhibitor Synergy in PTENLOF/BRAFMUT Melanoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAFMUT) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most likely because these pathways constitute a codependent signaling network. Concomitant PTEN loss of function (PTENLOF) occurs in approximately 40% of BRAFMUT […]
Translating psoriasis guidelines into practice: Important gaps revealed
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
There is a well-established lack of adherence to evidence-based clinical guidelines. The American Academy of Dermatology (AAD) developed educational sessions entitled Translating Evidence into Practice based on the published guidelines for psoriasis and psoriatic arthritis. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Q9SKg8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader […]
Molecular Targets of Tumor Dissemination
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the development of more effective therapies. Peritoneal dissemination of this type of malignancy has been generally thought to initiate from “milky spots” of primitive lymphoid tissues in the peritoneal cavity. In this study, we offer evidence challenging […]
carriage rates and antibiotic resistance patterns in patients with acne vulgaris
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Overuse of antibiotics has led to the development of antibiotic-resistant strains of Staphylococcus aureus, which are occurring more frequently within the community. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SRkCXj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lcCM8h via IFTTT
Melanoma Phenotype-Dependent Mast Cell Recruitment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Human melanomas exhibit considerable genetic, pathologic, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing to melanoma pathogenesis, but their ability to recapitulate the phenotypic variability of human disease and the complex interactions with the immune system have not been addressed. Here, we report the unexpected finding that […]
Skin color parameters and Fitzpatrick phototypes in estimating the risk of skin cancer: A case-control study in the Polish population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Light skin pigmentation is a known risk factor for skin cancer. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PvmpvN via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3JhrU via IFTTT
A video-based educational pilot for basal cell carcinoma (BCC) treatment: A randomized controlled trial
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Several treatment options exist for uncomplicated basal cell carcinoma. Standardized and effective informed consent is difficult in busy dermatology clinics. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1nmIru3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lcCOwR via IFTTT
Cyclin D1 and DNA Damage Sensing
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Therapy resistance and poor outcome in prostate cancer is associated with increased expression of cyclin D1. Androgens promote DNA double-strand break repair to reduce DNA damage, and cyclin D1 was also shown to enhance DNA damage repair (DDR). In this study, we investigated the significance of cyclin D1 in androgen-induced DDR using established prostate cancer […]
Treatment of compound tibia fracture with microvascular latissimus dorsi flap and the Ilizarov technique: a cross-sectional study of long-term outcomes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Exensive compound tibial fractures presents reconstructive challenges. The present study aimed to assess the outcomes of microvascular latissimus dorsi (LD) flap combined with the Ilizarov technique for extensive compound tibial fractures with bone loss and bone healing complications. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PeDCJp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros […]
IL21 Signaling in Anti-ErbB2 Therapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The HER2/ErbB2 monoclonal antibody (mAb) trastuzumab is combined with chemotherapy as a standard-of-care for newly diagnosed HER2+ breast cancer patients, but some patients treated with this combination therapy experience early relapse. Our analysis of data from a clinical trial evaluating the efficacy of chemotherapy plus/minus trastuzumab suggested that the magnitude of trastuzumab benefit on distant […]
Atrophy of anterior digastric muscle detected during ultrasound of the neck - a prospective clinical study
Anatomical variants that affect both the anterior and posterior digastric muscles are well described, and include duplications and variable origin or sites of insertion. Although agenesis or atrophy of the anterior digastric occurs in up to 40% of patients with hemifacial microsomia, to our knowledge, it has been reported only rarely in those without this syndrome. To minimise observer bias and to establish the incidence of anomalies and atrophy of this muscle, a prospective 6-year study was conducted by an experienced consultant radiologist in all patients referred for ultrasound ... περισσότερα »
Nasofacial angle and nasal prominence: A quantitative investigation of idealized and normative values
A quantitative evaluation of the influence of the nasofacial angle on perceived attractiveness and threshold values of desire for rhinoplasty. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1ZyXNg6 via IFTTT
carriage rates and antibiotic resistance patterns in patients with acne vulgaris
Overuse of antibiotics has led to the development of antibiotic-resistant strains of Staphylococcus aureus, which are occurring more frequently within the community. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SRkCXj via IFTTT
Skin color parameters and Fitzpatrick phototypes in estimating the risk of skin cancer: A case-control study in the Polish population
Light skin pigmentation is a known risk factor for skin cancer. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PvmpvN via IFTTT
A video-based educational pilot for basal cell carcinoma (BCC) treatment: A randomized controlled trial
Several treatment options exist for uncomplicated basal cell carcinoma. Standardized and effective informed consent is difficult in busy dermatology clinics. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1nmIru3 via IFTTT
Like Reading Our Journals? Why Not Earn ASHA CEUs While You're at It?
from #Audiology via ola Kala on Inoreader http://ift.tt/1Q9HW1E via IFTTT
