The relationship between liver stiffness measurement and outcome in patients with chronic hepatitis C and cirrhosis: a retrospective longitudinal hospital study
Summary Background There is a relationship between liver stiffness measurement (LSM) and outcome of HCV patients. Aim To evaluate the performance of LSM to predict outcome of HCV patients at risk of liver-related complication. Methods We established a retrospective longitudinal cohort of 341 HCV patients with unequivocal cirrhosis. All underwent LSM and were followed from September 2006 to July 2015. Outcome measure was a composite end-point of end-stage liver disease (ESLD) and/or hepatocellular carcinoma (HCC). Cox models and areas under receiver operating characteristic (AUR... περισσότερα »
PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers
[image: cover.gif?v=1&s=cf04ac26a9387c4e45e51322] Abstract The spleen tyrosine kinase (SYK) regulates immune cell activation in response to ligation of a variety of receptors, making it an intriguing target for the treatment of inflammatory and autoimmune disorders, as well as certain B cell malignancies. We have previously reported on the discovery and pre-clinical characterization of PRT062607, a potent and highly selective inhibitor of SYK that exhibits robust anti-inflammatory activity in a variety of animal models. Here we present data from our first human studies aimed at c... περισσότερα »
The relationship between liver stiffness measurement and outcome in patients with chronic hepatitis C and cirrhosis: a retrospective longitudinal hospital study
Summary Background There is a relationship between liver stiffness measurement (LSM) and outcome of HCV patients. Aim To evaluate the performance of LSM to predict outcome of HCV patients at risk of liver-related complication. Methods We established a retrospective longitudinal cohort of 341 HCV patients with unequivocal cirrhosis. All underwent LSM and were followed from September 2006 to July 2015. Outcome measure was a composite end-point of end-stage liver disease (ESLD) and/or hepatocellular carcinoma (HCC). Cox models and areas under receiver operating characteristic (AUR... περισσότερα »
New biomarkers and therapeutics can be discovered during COPD-lung cancer transition
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
from Cell via ola Kala on Inoreader http://ift.tt/29WffII via IFTTT
Characterization of an AAC-11-derived anticancer peptide
AAC-11 is an anti-apoptotic protein that is upregulated in most cancer cells. Increased expression of AAC-11 confers a survival advantage when cancer cells are challenged with various stresses and contributes to tumor invasion and metastases whereas its deregulation reduces resistance to chemotherapeutic drugs. The antiapoptotic effect of AAC-11 may be clinically relevant as its expression correlates with poor prognosis in several human cancers. Thus, inactivation of AAC-11 might constitute an attractive approach for developing cancer therapeutics. We have developed an AAC-11-deri... περισσότερα »
Characterization of an AAC-11-derived anticancer peptide
AAC-11 is an anti-apoptotic protein that is upregulated in most cancer cells. Increased expression of AAC-11 confers a survival advantage when cancer cells are challenged with various stresses and contributes to tumor invasion and metastases whereas its deregulation reduces resistance to chemotherapeutic drugs. The antiapoptotic effect of AAC-11 may be clinically relevant as its expression correlates with poor prognosis in several human cancers. Thus, inactivation of AAC-11 might constitute an attractive approach for developing cancer therapeutics. We have developed an AAC-11-deri... περισσότερα »
Characterization of an AAC-11-derived anticancer peptide
AAC-11 is an anti-apoptotic protein that is upregulated in most cancer cells. Increased expression of AAC-11 confers a survival advantage when cancer cells are challenged with various stresses and contributes to tumor invasion and metastases whereas its deregulation reduces resistance to chemotherapeutic drugs. The antiapoptotic effect of AAC-11 may be clinically relevant as its expression correlates with poor prognosis in several human cancers. Thus, inactivation of AAC-11 might constitute an attractive approach for developing cancer therapeutics. We have developed an AAC-11-derive... περισσότερα »
Characterization of an AAC-11-derived anticancer peptide
AAC-11 is an anti-apoptotic protein that is upregulated in most cancer cells. Increased expression of AAC-11 confers a survival advantage when cancer cells are challenged with various stresses and contributes to tumor invasion and metastases whereas its deregulation reduces resistance to chemotherapeutic drugs. The antiapoptotic effect of AAC-11 may be clinically relevant as its expression correlates with poor prognosis in several human cancers. Thus, inactivation of AAC-11 might constitute an attractive approach for developing cancer therapeutics. We have developed an AAC-11-deri... περισσότερα »
Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge
[image: cover.gif?v=1&s=a7ea901f55e135f2a892ad12] Lymphocyte migration, which is essential for effective immune responses, belongs to the so-called amoeboid migration. The lymphocyte migration is up to 100 times faster than between mesenchymal and epithelial cell types. Migrating lymphocytes are highly polarized in three well-defined structural and functional zones: uropod, medial zone and leading edge. The actiomyosin-dependent driving force moves forward the uropod, whereas massive actin rearrangements protruding the cell membrane are observed at the leading edge. These actin re... περισσότερα »
Seek and Ye Shall Find Fibrillations [Editorials]
from Neurology via xlomafota13 on Inoreader http://ift.tt/29AzwOy via IFTTT
Remote Intracerebral Hemorrhage After Intravenous Thrombolysis: Results From a Multicenter Study [Original Contribution]
Background and Purpose— Remote parenchymal hemorrhage (rPH) after intravenous thrombolysis with recombinant tissue-type plasminogen activator may be associated with cerebral amyloid angiopathy, although supportive data are limited. We aimed to investigate risk factors of rPH after intravenous thrombolysis with recombinant tissue-type plasminogen activator. Methods— This is an observational study of patients with ischemic stroke who were treated with intravenous thrombolysis with recombinant tissue-type plasminogen activator and were included in a multicenter prospective registr... περισσότερα »
Carotid-Cavernous Fistula: A Rare but Treatable Cause of Rapidly Progressive Vision Loss [Illustrative Teaching Case]
[image: crossmark_button.png] from Neurology via xlomafota13 on Inoreader http://ift.tt/29HMQEn via IFTTT
Editorial Board/Reviewing Committee
from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29CAF91 via IFTTT
Editorial Board/Reviewing Committee
http://ift.tt/29CAF91
Metastatic pattern of invasive lobular carcinoma of the breast—Emphasis on gastric metastases
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Background and Objectives Breast invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have different metastatic patterns, but the exact pattern of metastases from ILC is poorly known. This study aimed to determine the frequency of ILC metastases in atypical locations, with an emphasis on gastric metastases. Methods Patients with ILC treated at the Saint–Sacrement Hospital (Quebec City, Canada) and the Maisonneuve–Rosemont Hospital (Montreal, Canada) between January 2003 and December 2009 were retrospectively reviewed. Demographic, clinical, and follow-up data wer... περισσότερα »
Sensitivity Analysis of a Physiologically Based Pharmacokinetic Model Used for Treatment Planning in Peptide Receptor Radionuclide Therapy
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. from Cancer via xlomafota13 on Inoreader http://ift.tt/29W9TwR via IFTTT http://ift.tt/29WcgzN
New Glucocyclic RGD Dimers for Positron Emission Tomography Imaging of Tumor Integrin Receptors
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. from Cancer via xlomafota13 on Inoreader http://ift.tt/29Q6Mns via IFTTT http://ift.tt/29Q9YPU
Trajectories of stress and immunity
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Purpose. Five-year disease endpoint trajectories are available for every cancer site. In contrast, there are few longitudinal, biobehavioral studies of survivors extending beyond the first or second year following diagnosis. This gap is addressed with stress, depressive symptom, and immunity data from breast cancer patients followed continuously for 5 years. Methods. Women (N=113) diagnosed and surgically treated for breast cancer and awaiting adjuvant therapy completed self-report measures of stress and depressive symptoms and provided blood for immune assays [natural killer cell... περισσότερα »
BOIN: A Simple, Well-Performing Bayesian Phase I Design
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Despite more than two decades of publications that offer more innovative model-based designs, the classical 3+3 design remains the most dominant phase I trial design in practice. In this article, we introduce a new trial design, the Bayesian optimal interval (BOIN) design. The BOIN design is easy to implement in a way similar to the 3+3 design, but is more flexible for choosing the target toxicity rate and cohort size and yields a substantially better performance that is comparable to that of more complex model-based designs. The BOIN design contains the 3+3 design and the acceler... περισσότερα »
Tumor expression of vitamin D receptor and breast cancer
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 25 δευτερόλεπτα
Purpose: Our previous work has shown low serum 25-hydroxyvitamin D concentrations in association with aggressive breast cancer subtypes. Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Few studies have examined breast VDR expression with tumor characteristics or patient survival. Experimental Design: VDR expression in breast tumor tissue microarrays was determined by immunohistochemistry in 1,114 female patients as low, moderate and strong expression based on an immunoreactive score, and examined with histopathological tumor characteristics and... περισσότερα »
miR-644a Functions as Tumor Suppressor in ESCC
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 27 δευτερόλεπτα
Purpose: We previously reported the oncogenic role of paired-like homeodomain 2 (PITX2) in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to identify the microRNA (miRNA) regulators of PITX2 and the mechanism underlying the pathogensis of ESCC. Experimental Design: Using miRNA profiling and bioinformatics analyses, we identified miR-644a as a negative mediator of PITX2 in ESCC. A series of in vivo and in vitro assays were performed to confirm the effect of miR-644a on PITX2-mediated ESCC malignancy. Results: ESCC cells and tissues expressed less miR-644a than n... περισσότερα »
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
Postoperative pain is a remaining issue in tonsillectomy. Polyglycolic acid (PGA) is a biocompatible material used for absorbent suture reinforcement, and its sheet has been applied for covering defects after resection of oral carcinoma. The aim of this study is to examine whether the attachment of a PGA sheet to surgical wounds would reduce posttonsillectomy… Continue reading Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
Cricohyoidoepiglottopexy in Laryngeal Trauma
http://ift.tt/2a7TaTJ http://ift.tt/29uO2fs OtoRhinoLaryngology by Alexandros G. Sfakianakis from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29MulPA via IFTTT
Unfavorable outcome of unilateral cleft lip repair
Unfavorable outcome of unilateral cleft lip repair: SM Balaji Annals of Maxillofacial Surgery 2016 6(1):3-3 Unilateral cleft lip is one of the most common congenital deformities encountered in maxillofacial practice. With the evolution of the advanced understanding of locoregional anatomy and mechanism behind cleft lips, today, surgeons can provide a complete and immediate relief to… Continue reading Unfavorable outcome of unilateral cleft lip repair
In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction
In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction: Michael H Carstens Annals of Maxillofacial Surgery 2016 6(1):1-2 Many years ago, UCLA orthopedic surgeon Marshall Urist, working on what became recombinant human bone morphogenetic protein 2 (rhBMP-2), envisioned that rhBMP-2 would be destined to bring the control of bone formation into… Continue reading In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction
American Journal of Otolaryngology
Article in Press The effect of tacrolimus on facial nerve injury: histopathological findings in a rabbit model☆☆☆☆☆☆☆☆☆☆ Full Text Images References PDF (653 KB) Download Images(.ppt)About Images & Usage Email Article Add to My Reading List Export Citation Create Citation Alert Cited by in Scopus (0) Kamil Gokce Tulaci, M.D , Arzu Tuzuner, M.D ,… Continue reading American Journal of Otolaryngology
Influence of previous treatment of oral squamous cell carcinoma on the geographic distribution of recurrent neck metastases: a case series of unusual level IV metastases
Influence of previous treatment of oral squamous cell carcinoma on the geographic distribution of recurrent neck metastases: a case series of unusual level IV metastases: Cervical node management is vital for the successful treatment of oral squamous cell carcinoma (OSCC). Lymphatic spread from intra-oral malignancies usually follows a predictable path. We report on two patients… Continue reading Influence of previous treatment of oral squamous cell carcinoma on the geographic distribution of recurrent neck metastases: a case series of unusual level IV metastases
Transcanalicular Diode Laser Supported Endoscopic Dacryocystorhinostomy and Non-laser Endoscopic Dacryocystorhinostomy
A comparative study of Transcanalicular Diode Laser Supported Endoscopic Dacryocystorhinostomy and Non-laser Endoscopic Dacryocystorhinostomy: The primary surgical procedure for nasolacrimal duct obstruction is dacryocystorhinostomy (DCR). The purpose of this study was to compare non-laser endoscopic dacryocystorhinostomy (NL-EnDCR) and transcanalicular diode laser-supported endoscopic dacryocystorhinostomy (TDLS-EnDCR). Abstract Objective The primary surgical procedure for nasolacrimal duct obstruction is… Continue reading Transcanalicular Diode Laser Supported Endoscopic Dacryocys... περισσότερα »
Metastatic pattern of invasive lobular carcinoma of the breast—Emphasis on gastric metastases
Background and Objectives Breast invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have different metastatic patterns, but the exact pattern of metastases from ILC is poorly known. This study aimed to determine the frequency of ILC metastases in atypical locations, with an emphasis on gastric metastases. Methods Patients with ILC treated at the Saint–Sacrement… Continue reading Metastatic pattern of invasive lobular carcinoma of the breast—Emphasis on gastric metastases
Sensitivity Analysis of a Physiologically Based Pharmacokinetic Model Used for Treatment Planning in Peptide Receptor Radionuclide Therapy
Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. http://ift.tt/29W9TwR from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29OfOER via IFTTT
New Glucocyclic RGD Dimers for Positron Emission Tomography Imaging of Tumor Integrin Receptors
Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. http://ift.tt/29Q6Mns from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29OBUE9 via IFTTT
Correction: Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients
by Fatima Ochoa-Gonzalez, Alberto R. Cervantes-Villagrana, Julio C. Fernandez-Ruiz, Hilda S. Nava-Ramirez, Adriana C. Hernandez-Correa, Jose A. Enciso-Moreno, Julio E. Castañeda-Delgado from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29UxkXr via IFTTT
Patterns of Cereal Yield Growth across China from 1980 to 2010 and Their Implications for Food Production and Food Security
[image: journal.pone.0159061.g004] by Xiaoyun Li, Nianjie Liu, Liangzhi You, Xinli Ke, Haijun Liu, Malan Huang, Stephen R. Waddington After a remarkable 86% increase in cereal production from 1980 to 2005, recent crop yield growth in China has been slow. County level crop production data between 1980 and 2010 from eastern and middle China were used to analyze spatial and temporal patterns of rice, wheat and maize yield in five major farming systems that include around 90% of China's cereal production. Site-specific yield trends were assessed in areas where those crops have experie... περισσότερα »
Correction: Body Size Regression Formulae, Proximate Composition and Energy Density of Eastern Bering Sea Mesopelagic Fish and Squid
[image: journal.pone.0159353.t001] by Elizabeth H. Sinclair, William A. Walker, James R. Thomason from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29OtmN5 via IFTTT
Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor
[image: journal.pone.0158950.g001] by Tamaki Hayase Like various stressors, the addictive use of nicotine (NC) is associated with emotional symptoms such as anxiety and depression, although the underlying mechanisms have not yet been fully elucidated due to the complicated involvement of target neurotransmitter systems. In the elicitation of these emotional symptoms, the fundamental involvement of epigenetic mechanisms such as histone acetylation has recently been suggested. Furthermore, among the interacting neurotransmitter systems implicated in the effects of NC and stressors, ... περισσότερα »
Cystinuria Associated with Different SLC7A9 Gene Variants in the Cat
[image: journal.pone.0159247.g001] by Keijiro Mizukami, Karthik Raj, Carl Osborne, Urs Giger Cystinuria is a classical inborn error of metabolism characterized by a selective proximal renal tubular defect affecting cystine, ornithine, lysine, and arginine (COLA) reabsorption, which can lead to uroliths and urinary obstruction. In humans, dogs and mice, cystinuria is caused by variants in one of two genes, *SLC3A1* and *SLC7A9*, which encode the rBAT and bo,+AT subunits of the bo,+ basic amino acid transporter system, respectively. In this study, exons and flanking regions of the *S... περισσότερα »
Risk Factors for Bovine Tuberculosis (bTB) in Cattle in Ethiopia
[image: journal.pone.0159083.t004] by Sintayehu W. Dejene, Ignas M. A. Heitkönig, Herbert H. T. Prins, Fitsum A. Lemma, Daniel A. Mekonnen, Zelalem E. Alemu, Tessema Z. Kelkay, Willem F. de Boer Bovine tuberculosis (bTB) infection is generally correlated with individual cattle's age, sex, body condition, and with husbandry practices such as herd composition, cattle movement, herd size, production system and proximity to wildlife—including bTB maintenance hosts. We tested the correlation between those factors and the prevalence of bTB, which is endemic in Ethiopia's highland cattle... περισσότερα »
Estimation of the Undiagnosed Intervals of HIV-Infected Individuals by a Modified Back-Calculation Method for Reconstructing the Epidemic Curves
[image: journal.pone.0159021.e001.PNG] by Ngai Sze Wong, Ka Hing Wong, Man Po Lee, Owen T. Y. Tsang, Denise P. C. Chan, Shui Shan Lee Background Undiagnosed infections accounted for the hidden proportion of HIV cases that have escaped from public health surveillance. To assess the population risk of HIV transmission, we estimated the undiagnosed interval of each known infection for constructing the HIV incidence curves. Methods We used modified back-calculation methods to estimate the seroconversion year for each diagnosed patient attending any one of the 3 HIV specialist clini... περισσότερα »
Biodiversity and Temporal Distribution of Immature Culicidae in the Atlantic Forest, Rio de Janeiro State, Brazil
[image: journal.pone.0159240.t001] by Jeronimo Alencar, Cecília Ferreira de Mello, Nicolau Maués Serra-Freire, Anthony Érico Guimarães, Hélcio R. Gil-Santana, Raquel M. Gleiser To increase the knowledge of biodiversity and identify larval habitats used by immature mosquitoes in the Atlantic Forest, we conducted a study in areas with various stages of preservation within the Guapiaçu Ecological Reserve in Cachoeiras de Macacu, Rio de Janeiro state. The Culicidae fauna were sampled during February, April, June, August, October, and December 2012; February, March, April, May, June, Au... περισσότερα »
FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells
[image: journal.pone.0159234.g001] by Mi Nam Lee, Jung-Woo Kim, Sin-Hye Oh, Byung-Chul Jeong, Yun-Chan Hwang, Jeong-Tae Koh Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an orphan nuclear receptor that regulates many key biological processes, including organ development and cell fate determination. Although the biological functions of COUP-TFII have been studied extensively, little is known about what regulates its gene expression, especially the role of inducible extracellular factors in triggering it. Here we report that COUP-TFII expression is regul... περισσότερα »
Identification and Validation of SNP Markers Linked to Dwarf Traits Using SLAF-Seq Technology in Lagerstroemia
[image: journal.pone.0158970.g001] by Yuanjun Ye, Ming Cai, Yiqian Ju, Yao Jiao, Lu Feng, Huitang Pan, Tangren Cheng, Qixiang Zhang The genetic control of plant architecture is a promising approach to breed desirable cultivars, particularly in ornamental flowers. In this study, the F1 population (142 seedlings) derived from *Lagerstroemia fauriei* (non-dwarf) × *L*. *indica* 'Pocomoke' (dwarf) was phenotyped for six traits (plant height (PH), internode length (IL), internode number, primary lateral branch height (PLBH), secondary lateral branch height and primary branch number), a... περισσότερα »
Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells
[image: journal.pone.0159199.g001] by Akos A. Gerencser, Shona A. Mookerjee, Martin Jastroch, Martin D. Brand The aim of this study was to simplify, improve and validate quantitative measurement of the mitochondrial membrane potential (ΔψM) in pancreatic β-cells. This built on our previously introduced calculation of the absolute magnitude of ΔψM in intact cells, using time-lapse imaging of the non-quench mode fluorescence of tetramethylrhodamine methyl ester and a bis-oxonol plasma membrane potential (ΔψP) indicator. ΔψM is a central mediator of glucose-stimulated insulin secretio... περισσότερα »
Timescale- and Sensory Modality-Dependency of the Central Tendency of Time Perception
[image: journal.pone.0158921.g001] by Yuki Murai, Yuko Yotsumoto When individuals are asked to reproduce intervals of stimuli that are intermixedly presented at various times, longer intervals are often underestimated and shorter intervals overestimated. This phenomenon may be attributed to the central tendency of time perception, and suggests that our brain optimally encodes a stimulus interval based on current stimulus input and prior knowledge of the distribution of stimulus intervals. Two distinct systems are thought to be recruited in the perception of sub- and supra-second i... περισσότερα »
Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers
[image: journal.pone.0159181.g001] by Jill A. Rahnert, Bin Zheng, Matthew B. Hudson, Myra E. Woodworth-Hobbs, S. Russ Price Muscle wasting associated with chronic diseases has been linked to decreased expression of PGC-1α and overexpression of PGC-1α counters muscle loss. CREB, in conjunction with the CREB-regulated transcription coactivator (CRTC2), is a positive modulator of PGC-1α transcription. We previously reported that PGC-1α expression is decreased in skeletal muscle of diabetic rats despite a high level of CREB phosphorylation (i.e., activation), suggesting that CRTC2-CRE... περισσότερα »
Gene Expression and DNA Methylation Status of Glutathione S-Transferase Mu1 and Mu5 in Urothelial Carcinoma
[image: journal.pone.0159102.g001] by Shou-Chieh Wang, Chin-Chin Huang, Cheng-Huang Shen, Lei-Chen Lin, Pei-Wen Zhao, Shih-Ying Chen, Yu-Chiao Deng, Yi-Wen Liu Bladder cancer is highly recurrent after therapy, which has an enormous impact on the health and financial condition of the patient. It is worth developing diagnostic tools for bladder cancer. In our previous study, we found that the bladder carcinogen BBN increased urothelial global DNA CpG methylation and decreased GSTM1 protein expression in mice. Here, the correlation of BBN-decreased GSTM1 and GSTM gene CpG methylation ... περισσότερα »
Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability
[image: journal.pone.0159180.g001] by Laura Lori, Alessandra Pasquo, Clorinda Lori, Maria Petrosino, Roberta Chiaraluce, Cynthia Tallant, Stefan Knapp, Valerio Consalvi Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the recruitment of transcriptional regulators and chromatin remodelling enzymes to acetylated sites in chromatin. Recent st... περισσότερα »
Identification and Validation of Loci Governing Seed Coat Color by Combining Association Mapping and Bulk Segregation Analysis in Soybean
[image: journal.pone.0159064.g001] by Jian Song, Zhangxiong Liu, Huilong Hong, Yansong Ma, Long Tian, Xinxiu Li, Ying-Hui Li, Rongxia Guan, Yong Guo, Li-Juan Qiu Soybean seed coat exists in a range of colors from yellow, green, brown, black, to bicolor. Classical genetic analysis suggested that soybean seed color was a moderately complex trait controlled by multi-loci. However, only a couple of loci could be detected using a single biparental segregating population. In this study, a combination of association mapping and bulk segregation analysis was employed to identify genes/loci... περισσότερα »
Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies
[image: journal.pone.0159165.g001] by Camille Attané, Marie-Line Peyot, Roxane Lussier, Dongwei Zhang, Erik Joly, S. R. Murthy Madiraju, Marc Prentki Many metabolic studies employ tissue-specific gene knockout mice, which requires breeding of floxed gene mice, available mostly on C57BL/6N (NN) genetic background, with cre or Flp recombinase-expressing mice, available on C57BL/6J (JJ) background, resulting in the generation of mixed C57BL/6NJ (NJ) genetic background mice. Recent awareness of many genetic differences between NN and JJ strains including the deletion of nicotinamide nu... περισσότερα »
Lighting and marking policies are associated with reduced farm equipment-related crash rates: a policy analysis of nine Midwestern US states
Objective To evaluate the effectiveness of roadway policies for lighting and marking of farm equipment in reducing crashes in Illinois, Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, South Dakota and Wisconsin. Methods In this ecological study, state policies on lighting and marking of farm equipment were scored for compliance with standards of the American Society of Agricultural and Biological Engineers (ASABE). Using generalized estimating equations negative binomial models, we estimated the relationships between lighting and marking scores, and farm equipment cra... περισσότερα »
Instrument Development in Choice Experiments. Commentary on: “Applying a Framework for Instrument Development of a Choice Experiment to Measure Treatment Preferences in Type 2 Diabetes”
from Medicine via xlomafota13 on Inoreader http://ift.tt/29uOO8K via IFTTT
“I Don’t Need Help”: Gender Differences in how Gender Stereotypes Predict Help-Seeking
Abstract Although self-report and correlational studies suggest that gender stereotypes are related to men's health behavior, particularly in relation to seeking help, there is minimal research that has tested this hypothesis experimentally. The present study examined how two stereotype pathways, personally endorsed gender stereotypes and gender stereotyped attitudes, predicted help-seeking behavior among U.S. undergraduate women (*n* = 68) and men (*n* = 72) when they worked on challenging puzzles and recalled previous health help-seeking behavior for physical or psychological pr... περισσότερα »
Contextualizing Students’ Alcohol Use Perceptions and Practices within French Culture: An Analysis of Gender and Drinking among Sport Science College Students
Abstract Although research has examined alcohol consumption and sport in a variety of contexts, there is a paucity of research on gender and gender dynamics among French college students. The present study addresses this gap in the literature by examining alcohol use practices by men and women among a non-probability sample of French sport science students from five different universities in Northern France. We utilized both survey data (*N* = 534) and in-depth qualitative interviews (*n* = 16) to provide empirical and theoretical insight into a relatively ubiquitous health concern... περισσότερα »
Prognostic Value of C-Reactive Protein in Resistant Hypertension
BACKGROUND C-reactive protein (CRP) is a biomarker of systemic low-grade inflammation and a cardiovascular risk predictor in several clinical conditions. However, its prognostic value has never been examined in patients with resistant hypertension. METHODS In a prospective study, 476 patients with resistant hypertension had CRP levels measured at baseline, together with other clinical laboratory variables, including ambulatory blood pressures (BPs). Primary end points were a composite of major fatal or nonfatal cardiovascular events, all-cause mortality, and cardiovascular mort... περισσότερα »
A Randomized Trial of a Low-Fat Diet Intervention on Blood Pressure and Hypertension: Tertiary Analysis of the WHI Dietary Modification Trial
BACKGROUND This *post hoc analysis* determined if the Women's Health Initiative (WHI) Diet Modification intervention (DM-I) resulted in a significantly different rate of incident hypertension (HTN), as well as longitudinal changes in blood pressure. METHODS Participants were 48,835 postmenopausal women aged 50–79 years who were randomly assigned to either the intervention or comparison group. HTN was defined as self-report of treated HTN collected semiannually or blood pressure ≥140/90mm Hg at one of the annual follow-up clinic visits. RESULTS After a mean follow-up of 8.3 yea... περισσότερα »
Key Considerations and Methods in the Study of Gene-Environment Interactions
With increased involvement of genetic data in most epidemiological investigations, gene–environment (G x E) interactions now stand as a topic, which must be meticulously assessed and thoroughly understood. The level, mode, and outcomes of interactions between environmental factors and genetic traits have the capacity to modulate disease risk. These must, therefore, be carefully evaluated as they have the potential to offer novel insights on the "missing heritability problem", reaching beyond our current limitations. First, we review a definition of G x E interactions. We then expl... περισσότερα »
Aldosterone Antagonists or Renin-Guided Therapy for Treatment-Resistant Hypertension: A Comparative Effectiveness Pilot Study in Primary Care
BACKGROUND Uncontrolled treatment-resistant hypertension (TRH), i.e., blood pressure (BP, mm Hg) ≥140/≥90mm Hg in and out of office on ≥3 different BP medications at optimal doses, is common and has a poor prognosis. Aldosterone antagonist (AA) and renin-guided therapy (RGT) are effective strategies for improving BP control in TRH but have not been compared. METHODS A comparative effectiveness TRH pilot study of AA vs. RGT was conducted in 4 primary care clinics with 2 each randomized to AA or RGT. The primary outcome was change in clinic BP defined by means of 5 automated offic... περισσότερα »
Editorial Board/Reviewing Committee
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
http://ift.tt/29CAF91
Correlation Between Histological Diagnosis and Mutational Panel Testing of Thyroid Nodules: A Two-Year Institutional Experience
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
Thyroid , Vol. 0, No. 0. http://ift.tt/2a7Uq9k
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
Postoperative pain is a remaining issue in tonsillectomy. Polyglycolic acid (PGA) is a biocompatible material used for absorbent suture reinforcement, and its sheet has been applied for covering defects after resection of oral carcinoma. The aim of this study is to examine whether the attachment of a PGA sheet to surgical wounds would reduce posttonsillectomy pain. In this prospective single-blind study, 17 consecutive adult patients were recruited who needed to undergo tonsillectomy, mainly due to habitual tonsillitis. Following bilateral tonsillectomies, a PGA sheet was attached ... περισσότερα »
Cricohyoidoepiglottopexy in Laryngeal Trauma
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
http://ift.tt/2a7TaTJ
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age of 5 years (mean age, 23.3 years) with a pathologic diagnosis of micro-MTC without nodal involvement were enrolled. All patients underwent TT with thymectomy and central compartment lymph node dissection. During surgery, parathyr... περισσότερα »
Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα
We evaluated the efficacy of interpositional auricular cartilage grafting for perforation with an endoscopic endonasal approach via a mucosal regeneration technique. In total, 12 patients with symptomatic septal perforations were operated on by way of an endoscopic endonasal approach after an adequately sized cartilage graft was harvested. The graft was inserted between the circumferentially incised and elevated flaps of the perforation and secured by vertical and horizontal nonabsorbable aligning approximation stitches and prolonged placement of silicone splints. The average perf... περισσότερα »
Asian Targeted Temperature Management Task Panel Report
Therapeutic Hypothermia and Temperature Management , Vol. 0, No. 0. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29w2XCi
Transcanalicular Diode Laser Supported Endoscopic Dacryocystorhinostomy and Non-laser Endoscopic Dacryocystorhinostomy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
A comparative study of Transcanalicular Diode Laser Supported Endoscopic Dacryocystorhinostomy and Non-laser Endoscopic Dacryocystorhinostomy: The primary surgical procedure for nasolacrimal duct obstruction is dacryocystorhinostomy (DCR). The purpose of this study was to compare non-laser endoscopic dacryocystorhinostomy (NL-EnDCR) and transcanalicular diode laser-supported endoscopic dacryocystorhinostomy (TDLS-EnDCR). Abstract Objective The primary surgical procedure for nasolacrimal duct obstruction is […]
Correlation Analysis of Oral Lesion Sizes by Various Standardized Criteria
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Correlation Analysis of Oral Lesion Sizes by Various Standardized Criteria: Requirements of an NCI contract examining a novel treatment for leukoplakia were to compare standard bi-dimensional measurement of oral lesions to examine for correlation with Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and to examine the feasibility of digital image analysis for automated measurements. […]
Magnetic Nanoparticles in Medical Diagnostic Applications: Synthesis, Characterization and Proteins Conjugation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Magnetic Nanoparticles in Medical Diagnostic Applications: Synthesis, Characterization and Proteins Conjugation: Background: Magnetic nanoparticles (NPs) used in biomedical applications should be discrete with small particle sizes, narrow size distribution and superparamagnetic. NPs can be tailored to target, through chemical bonds, specific organs, cells, or even molecular markers of different diseases in vivo, with suitable surface […]
Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury – A Review
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury – A Review: Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been […]
Injectable Liposomal Formulations: Systematic Analysis for Regulatory Purposes
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Injectable Liposomal Formulations: Systematic Analysis for Regulatory Purposes: Background: Among the drug delivery systems, liposomes stand out for their biocompatible and biodegradable characteristics and high versatility. There are many marketed liposomal drug products, most of them injectables. From a regulatory perspective, some documents were published by FDA and EMA, but a systematic analysis of the […]
Prehospital diagnosis of asthma and COPD
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Prove it: Is it asthma or COPD?: Medic 23 and Engine 16 respond to a private residence for shortness of breath. Both arrive to find a 59-year-old female who says she is having difficulty breathing, which she attributes to a bad cold. Although she has these episodes occasionally, she had a flu vaccination this year […]
Hydroxycinnamic acids in cooked potato tubers from Solanum tuberosum group Phureja
Abstract Hydroxycinnamic acids are phenolic compounds and are considered to have health promotion properties due to their antioxidant activity. Potato tubers of 113 genotypes of *Solanum tuberosum* group Phureja belonging to the Colombian Central Collection, landraces of potatoes, and commercial cultivars were evaluated for their hydroxycinnamic acids content. The composition of these compounds was analyzed using cooked tubers in two different agro-climatic conditions. The genotypes were analyzed for chlorogenic acid, *neo*-chlorogenic acid, *crypto*-chlorogenic acid, and caffeic a... περισσότερα »
Metastatic clear cell variant of renal cell carcinoma of the mandible: Review and case report
*Ajaz Shah, Shahi Jahan, Latief Najar, Shahid Hassan, Manzoor Mohammad* Annals of Maxillofacial Surgery 2016 6(1):144-147 A case of metastatic renal cell carcinoma (RCC) to the mandible is reported. A 22-year-old man consulted us for hypoesthesia of the right lower lip. Panorama X-ray film showed a radiolucent lesion in the right mandibular body. A diagnosis of a metastatic tumor to the mandible from the right kidney was made after evaluation by computed tomography and bone scan with Tc99 methyl diphosphonate which also revealed multiple bone metastases. Histologically diagnosis w... περισσότερα »
Intermaxillary fixation screws versus Erich arch bars in mandibular fractures: A comparative study and review of literature
*Ahtesham Ahmad Qureshi, Umesh K Reddy, NM Warad, Sheeraz Badal, Amjad Ali Jamadar, Nilofar Qurishi* Annals of Maxillofacial Surgery 2016 6(1):25-30 Objective: Various techniques have been employed from time to time to achieve maxillomamdibular fixation. Although arch bars provide an effective and versatile means of maxillomandibular fixation, their use is not without shortcomings. However the introduction of intermaxillary fixation screws (IMF) has eliminated many of these issues of arch bars. The aim of the present study was to compare the advantages and disadvantages of interm... περισσότερα »
Unfavorable outcome of unilateral cleft lip repair
*SM Balaji* Annals of Maxillofacial Surgery 2016 6(1):3-3 http://ift.tt/29NU8Zq http://ift.tt/2a7AFPq OtoRhinoLaryngology by Alexandros G. Sfakianakis
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 3: Prevailing controversial theories related to Pierre Robin sequence
*Kurt-W Bütow, Roger Arthur Zwahlen, Jean A Morkel, Sharan Naidoo* Annals of Maxillofacial Surgery 2016 6(1):38-43 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to hist... περισσότερα »
The use of superficial cervical plexus block in oral and maxillofacial surgical practice as an alternative to general anesthesia in selective cases
*R Kamal Kanthan* Annals of Maxillofacial Surgery 2016 6(1):4-8 Aim: (1) To assess the feasibility, safety, and effectiveness of superficial cervical plexus (SCP) block in oral and maxillofacial surgical (OMFS) practice as an alternative to general anesthesia in selective cases. (2) To assess any associated complication specifically related to the procedure. Subjects and Methods: The total number of patients was 10, out of which 6 were male and 4 were female patients. Six patients had incision and drainage of perimandibular space infections, two patients had Level Ib cervical lym... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 1: History, subdivisions, and data
*Kurt-W Bütow, Roger Arthur Zwahlen, Jean A Morkel, Sharan Naidoo* Annals of Maxillofacial Surgery 2016 6(1):31-34 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in scientific literature related to history,... περισσότερα »
The use of a dynamic real-time jaw tracking device and cone beam computed tomography simulation
*Shushu He, Chung How Kau, Lina Liao, Keith Kinderknecht, Andrew Ow, Tayem Abou Saleh* Annals of Maxillofacial Surgery 2016 6(1):113-119 Background: The aim was to introduce and preliminarily evaluate a new software application, SICAT Function, which can directly combine and merge three-dimensional cone beam computed tomography (CBCT) and electronic SICAT jaw motion tracking (JMT) data. Methods: A detailed description of the methods and dynamic clinical simulation of mandibular movements of a patient are demonstrated. Functional jaw movements on 3 days were recorded by JMT tracki... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 2: Syndromic and nonsyndromic Pierre Robin sequence
*Kurt-W Bütow, Jean A Morkel, Sharan Naidoo, Roger Arthur Zwahlen* Annals of Maxillofacial Surgery 2016 6(1):35-37 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature, relating to history, clin... περισσότερα »
Radiographic and histological evaluation of ectopic application of deproteinized bovine bone matrix
*Rodrigo Carlos da Silva, Viviane Rozeira Crivellaro, Allan Fernando Giovanini, Rafaela Scariot, Carla Castiglia Gonzaga, João César Zielak* Annals of Maxillofacial Surgery 2016 6(1):9-14 Objective: To evaluate, through radiographic and histological analysis, the tissue reaction induced by a biomaterial based on deproteinized bovine bone matrix (DBBM) in the muscle of sheep. sMaterials and Methods: Sixteen sheep were used. The animals underwent surgery to insert polyethylene tubes containing the biomaterial in the muscle of the lower back (ectopic site) and were euthanized after 3... περισσότερα »
In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction
*Michael H Carstens* Annals of Maxillofacial Surgery 2016 6(1):1-2 http://ift.tt/29OkCa4 http://ift.tt/29D6gdf OtoRhinoLaryngology by Alexandros G. Sfakianakis
Piezo harvesting of bone grafts from the anterior iliac crest: A technical note
*Leena P Ylikontiola, Ville Lehtonen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):94-96 Background: Autogenous bone graft harvesting from the iliac crest is associated with donor site morbidity. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction. Materials and Methods: A piezosurgical handpiece and its selection of tips can easily be accommodated in an iliac crest wound to osteotomize and allow the harvest and delivery of autogenous bone grafts. Results: Corticocancellous blocks or cancellous strips of autogenous bone ... περισσότερα »
Zurich pediatric distractor for ramal condylar unit distraction in temporomandibular joint ankylosis
*Brig N.K Sahoo, ID Roy, Rohit Sharma, Maj Preeti Kaur* Annals of Maxillofacial Surgery 2016 6(1):101-104 Temporomandibular joint (TMJ) Ankylosis is an extremely disabling condition characterized by difficulty or inability to open the mouth resulting in facial asymmetry, malocclusion and dental problems. Surgical excision of the ankylosed mass is the only treatment option available to gain mouth opening. The loss in vertical height of ramus following release of ankylosis is difficult to manage in both unilateral and bilateral TMJ ankylosis. Out of all the methods to restore this h... περισσότερα »
Crouzon syndrome: Virtual planning of surgical treatment by application of internal distractors
*Chingiz Rahimov, Ruslan Asadov, Gunel Hajiyeva, Nazim Verdiyev, Zaur Novruzov, Ismayil Farzaliyev* Annals of Maxillofacial Surgery 2016 6(1):135-140 Crouzon syndrome is one of the frequent pathologies within craniosynostosis syndrome. Current progress in computers and biotechnologies allows improving surgical approach and forecasting final result of reconstruction as well. We present a case of successful surgical treatment of Crouzon syndrome, done by application of virtual planning allowing determining "monobloc" features, type of reconstruction and distraction protocol as well... περισσότερα »
A rare case of regression of brown tumors of tertiary hyperparathyroidism after parathyroidectomy and renal transplant: A 5-year follow-up
*José Wilson Noleto, Ivana Alencar Svenson Ramos, Julierme Ferreira Rocha, Idelmo Rangel Garcia, Berthiene M Salvador Roberto* Annals of Maxillofacial Surgery 2016 6(1):125-129 Tertiary hyperparathyroidism (HPT) is a rare condition that affects patients with secondary HPT, which develop hyperplasia of the parathyroid glands, thus causing an increase in parathyroid hormone levels. Bone alterations are the main consequences of this condition including the development of osteolytic lesions called brown tumor. This article reports an unusual case of brown tumors located in the maxilla... περισσότερα »
Large ameloblastic fibro-odontoma in a 7-year-old girl with analysis of 108 cases
*Antti Kirjavainen, Veikko Tuovinen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):15-20 Background: Odontogenic tumors such as ameloblastic fibro-odontoma (AFO) are rare conditions in children and are often asymptomatic. AFOs are found by routine clinical and radiological examination or when they cause obvious intra- or extra-oral swelling. Materials and Methods: A case of an AFO in a 7-year-old girl is described, and 107 cases from the literature and this report are analyzed. Results: The total of 108 cases revealed the average age at presentation of AFO to be 6.3 y... περισσότερα »
Autotransplantation donor tooth site harvesting using piezosurgery
*Leena P Ylikontiola, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):75-77 Background: The harvesting of a tooth as a candidate for tooth autotransplantation requires that the delicate dental tissues around the tooth be minimally traumatized. This is especially so for the periradicular tissues of the tooth root and the follicular tissues surrounding the crown. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction in the harvesting of teeth for autotransplantation. Methods: A piezosurgical handpiece and its selection of tips ... περισσότερα »
Primary rhinocheiloplasty: Comparison of open and closed methods of alar cartilage reposition
*SA Yasonov, AV Lopatin, A Yu Kugushev* Annals of Maxillofacial Surgery 2016 6(1):21-24 Aims: To establish which rhinoplasty method for primary repairing of unilateral cleft lip (UCL) is better. Settings and Design: Two patient groups with cleft lip were compared. Each group was operated on either by McComb's technique as closed rhinoplasty method or by Vissarionov–Kosin technique as an open method. Subjects and Methods: First group included 29 patients and the second consisted of 31. All patients were operated on by single surgeon over 10 years. Randomization was based on wishes ... περισσότερα »
Forgotten triangles of neck
*Manpreet Singh, Arpit Vashistha, Manoj Chaudhary, Gagandeep Kaur* Annals of Maxillofacial Surgery 2016 6(1):91-93 The purpose of this manuscript is to add some more information in the present scientific literature on these nearly forgotten triangles of surgical importance. The neck is an area that lends itself to anatomical geometry, such as triangles. Many triangles of the neck have been described, and some are well-known, yet, some have been nearly forgotten, i.e., Lesser's triangle, Farabeuf triangle, Pirogoff's triangle, and Beclard's triangle. From the anatomic and surgical ... περισσότερα »
Success rate of implants placed in autogenous bone blocks versus allogenic bone blocks: A systematic literature review
*Saeed Reza Motamedian, Moein Khojaste, Arash Khojasteh* Annals of Maxillofacial Surgery 2016 6(1):78-90 The aim of this study is to review and compare survival/success rate of dental implants inserted in autogenous and allogenic bone blocks (ALBs). A PubMed search was performed from January 1990 to June 2014 limited to English language and human studies. Studies that reported treatment outcome of implants inserted in augmented alveolar ridges with autogenous or ALBs were included. Primary search identified 470 studies. For autogenous bone block (ABB) 36 articles and for ALB 23 ar... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 4: Recommended management and treatment of Pierre Robin sequence and its application
*Kurt-W Bütow, Sharan Naidoo, Roger Arthur Zwahlen, Jean A Morkel* Annals of Maxillofacial Surgery 2016 6(1):44-49 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to hist... περισσότερα »
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Postoperative pain is a remaining issue in tonsillectomy. Polyglycolic acid (PGA) is a biocompatible material used for absorbent suture reinforcement, and its sheet has been applied for covering defects after resection of oral carcinoma. The aim of this study is to examine whether the attachment of a PGA sheet to surgical wounds would reduce posttonsillectomy […]
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age […]
Cricohyoidoepiglottopexy in Laryngeal Trauma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a7TaTJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
We evaluated the efficacy of interpositional auricular cartilage grafting for perforation with an endoscopic endonasal approach via a mucosal regeneration technique. In total, 12 patients with symptomatic septal perforations were operated on by way of an endoscopic endonasal approach after an adequately sized cartilage graft was harvested. The graft was inserted between the circumferentially incised […]
Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via Adenosine A2a receptor signalling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 11 July 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects Author(s): Smriti P.K. Mittal, Swati Khole, Nidhi Jagadish, Debjani Ghosh, Vijay Gadgil, Vilas Sinkar, Saroj S. Ghaskadbi BackgroundAndrographolide, principle constituent of Andrographis paniculata Nees is used in traditional medicine in Southeast Asia and is known to exhibit various biological activities. […]
Investigation into The distinct Subcellular Effects of Docosahexaenoic Acid Loaded Low-Density Lipoprotein Nanoparticles in normal and malignant murine liver cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 11 July 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects Author(s): Lacy R. Moss, Rohit S. Mulik, Tim Van Treuren, Soo Young Kim, Ian R. Corbin BackgroundRecent studies have shown that low density lipoproteins reconstituted with the natural omega 3 fatty acid docosahexaenoic acid (LDL-DHA) is selectively cytotoxic to liver […]
Geographic variation in the treatment of non-ST-segment myocardial infarction in the English National Health Service: a cohort study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Objectives To investigate geographic variation in guideline-indicated treatments for non-ST-elevation myocardial infarction (NSTEMI) in the English National Health Service (NHS). Design Cohort study using registry data from the Myocardial Ischaemia National Audit Project. Setting All Clinical Commissioning Groups (CCGs) (n=211) in the English NHS. Participants 357 228 patients with NSTEMI between 1 January 2003 and […]
Correction: Describing team development within a novel GP-led urgent care centre model: a qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Morton S, Igantowicz A, Gnani S, et al. Describing team development within a novel GP-led urgent care centre model: a qualitative study. BMJ Open 2016;6:e010224. The surname of the second author of this paper is misspelled. The correct spelling is: Ignatowicz. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29MoiKV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
Intra-articular bupivacaine after joint arthroplasty: a systematic review and meta-analysis of randomised placebo-controlled studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Objectives To evaluate the efficacy and safety of intra-articular (IA) bupivacaine administered for pain relief after joint arthroplasty. Design Meta-analysis. Methods A systematic review was conducted to identify the randomised controlled trials using IA bupivacaine for postoperative pain relief from MEDLINE, Cochrane Library and EMBASE databases (up to October 2015). The standardised mean difference (SMD), […]
Plea for routinely presenting prediction intervals in meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Objectives Evaluating the variation in the strength of the effect across studies is a key feature of meta-analyses. This variability is reflected by measures like 2 or I2, but their clinical interpretation is not straightforward. A prediction interval is less complicated: it presents the expected range of true effects in similar studies. We aimed to […]
Photobiomodulation: An Accepted Therapeutic Modality?
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/29AvlCm via IFTTT
Inhibition of Information Flow to the Default Mode Network During Self-Reference Versus Reference to Others
The default mode network (DMN), a network centered around the cortical midline, shows deactivation during most cognitive tasks and pronounced resting-state connectivity, but is actively engaged in self-reference and social cognition. It is, however, yet unclear how information reaches the DMN during social cognitive processing. Here, we addressed this question using dynamic causal modeling (DCM) of functional magnetic resonance imaging (fMRI) data acquired during self-reference (SR) and reference to others (OR). Both conditions engaged the left inferior frontal gyrus (LIFG), most ... περισσότερα »
In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction
*Michael H Carstens* Annals of Maxillofacial Surgery 2016 6(1):1-2 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29OkCa4 via IFTTT
Unfavorable outcome of unilateral cleft lip repair
*SM Balaji* Annals of Maxillofacial Surgery 2016 6(1):3-3 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29NU8Zq via IFTTT
The use of a dynamic real-time jaw tracking device and cone beam computed tomography simulation
*Shushu He, Chung How Kau, Lina Liao, Keith Kinderknecht, Andrew Ow, Tayem Abou Saleh* Annals of Maxillofacial Surgery 2016 6(1):113-119 Background: The aim was to introduce and preliminarily evaluate a new software application, SICAT Function, which can directly combine and merge three-dimensional cone beam computed tomography (CBCT) and electronic SICAT jaw motion tracking (JMT) data. Methods: A detailed description of the methods and dynamic clinical simulation of mandibular movements of a patient are demonstrated. Functional jaw movements on 3 days were recorded by JMT tracking... περισσότερα »
The use of superficial cervical plexus block in oral and maxillofacial surgical practice as an alternative to general anesthesia in selective cases
*R Kamal Kanthan* Annals of Maxillofacial Surgery 2016 6(1):4-8 Aim: (1) To assess the feasibility, safety, and effectiveness of superficial cervical plexus (SCP) block in oral and maxillofacial surgical (OMFS) practice as an alternative to general anesthesia in selective cases. (2) To assess any associated complication specifically related to the procedure. Subjects and Methods: The total number of patients was 10, out of which 6 were male and 4 were female patients. Six patients had incision and drainage of perimandibular space infections, two patients had Level Ib cervical lymph... περισσότερα »
Piezo harvesting of bone grafts from the anterior iliac crest: A technical note
*Leena P Ylikontiola, Ville Lehtonen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):94-96 Background: Autogenous bone graft harvesting from the iliac crest is associated with donor site morbidity. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction. Materials and Methods: A piezosurgical handpiece and its selection of tips can easily be accommodated in an iliac crest wound to osteotomize and allow the harvest and delivery of autogenous bone grafts. Results: Corticocancellous blocks or cancellous strips of autogenous bone ca... περισσότερα »
Radiographic and histological evaluation of ectopic application of deproteinized bovine bone matrix
*Rodrigo Carlos da Silva, Viviane Rozeira Crivellaro, Allan Fernando Giovanini, Rafaela Scariot, Carla Castiglia Gonzaga, João César Zielak* Annals of Maxillofacial Surgery 2016 6(1):9-14 Objective: To evaluate, through radiographic and histological analysis, the tissue reaction induced by a biomaterial based on deproteinized bovine bone matrix (DBBM) in the muscle of sheep. sMaterials and Methods: Sixteen sheep were used. The animals underwent surgery to insert polyethylene tubes containing the biomaterial in the muscle of the lower back (ectopic site) and were euthanized after 3 a... περισσότερα »
Crouzon syndrome: Virtual planning of surgical treatment by application of internal distractors
*Chingiz Rahimov, Ruslan Asadov, Gunel Hajiyeva, Nazim Verdiyev, Zaur Novruzov, Ismayil Farzaliyev* Annals of Maxillofacial Surgery 2016 6(1):135-140 Crouzon syndrome is one of the frequent pathologies within craniosynostosis syndrome. Current progress in computers and biotechnologies allows improving surgical approach and forecasting final result of reconstruction as well. We present a case of successful surgical treatment of Crouzon syndrome, done by application of virtual planning allowing determining "monobloc" features, type of reconstruction and distraction protocol as well. ... περισσότερα »
Large ameloblastic fibro-odontoma in a 7-year-old girl with analysis of 108 cases
*Antti Kirjavainen, Veikko Tuovinen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):15-20 Background: Odontogenic tumors such as ameloblastic fibro-odontoma (AFO) are rare conditions in children and are often asymptomatic. AFOs are found by routine clinical and radiological examination or when they cause obvious intra- or extra-oral swelling. Materials and Methods: A case of an AFO in a 7-year-old girl is described, and 107 cases from the literature and this report are analyzed. Results: The total of 108 cases revealed the average age at presentation of AFO to be 6.3 yea... περισσότερα »
Success rate of implants placed in autogenous bone blocks versus allogenic bone blocks: A systematic literature review
*Saeed Reza Motamedian, Moein Khojaste, Arash Khojasteh* Annals of Maxillofacial Surgery 2016 6(1):78-90 The aim of this study is to review and compare survival/success rate of dental implants inserted in autogenous and allogenic bone blocks (ALBs). A PubMed search was performed from January 1990 to June 2014 limited to English language and human studies. Studies that reported treatment outcome of implants inserted in augmented alveolar ridges with autogenous or ALBs were included. Primary search identified 470 studies. For autogenous bone block (ABB) 36 articles and for ALB 23 arti... περισσότερα »
Primary rhinocheiloplasty: Comparison of open and closed methods of alar cartilage reposition
*SA Yasonov, AV Lopatin, A Yu Kugushev* Annals of Maxillofacial Surgery 2016 6(1):21-24 Aims: To establish which rhinoplasty method for primary repairing of unilateral cleft lip (UCL) is better. Settings and Design: Two patient groups with cleft lip were compared. Each group was operated on either by McComb's technique as closed rhinoplasty method or by Vissarionov–Kosin technique as an open method. Subjects and Methods: First group included 29 patients and the second consisted of 31. All patients were operated on by single surgeon over 10 years. Randomization was based on wishes an... περισσότερα »
Zurich pediatric distractor for ramal condylar unit distraction in temporomandibular joint ankylosis
*Brig N.K Sahoo, ID Roy, Rohit Sharma, Maj Preeti Kaur* Annals of Maxillofacial Surgery 2016 6(1):101-104 Temporomandibular joint (TMJ) Ankylosis is an extremely disabling condition characterized by difficulty or inability to open the mouth resulting in facial asymmetry, malocclusion and dental problems. Surgical excision of the ankylosed mass is the only treatment option available to gain mouth opening. The loss in vertical height of ramus following release of ankylosis is difficult to manage in both unilateral and bilateral TMJ ankylosis. Out of all the methods to restore this hei... περισσότερα »
Intermaxillary fixation screws versus Erich arch bars in mandibular fractures: A comparative study and review of literature
*Ahtesham Ahmad Qureshi, Umesh K Reddy, NM Warad, Sheeraz Badal, Amjad Ali Jamadar, Nilofar Qurishi* Annals of Maxillofacial Surgery 2016 6(1):25-30 Objective: Various techniques have been employed from time to time to achieve maxillomamdibular fixation. Although arch bars provide an effective and versatile means of maxillomandibular fixation, their use is not without shortcomings. However the introduction of intermaxillary fixation screws (IMF) has eliminated many of these issues of arch bars. The aim of the present study was to compare the advantages and disadvantages of intermax... περισσότερα »
A rare case of regression of brown tumors of tertiary hyperparathyroidism after parathyroidectomy and renal transplant: A 5-year follow-up
*José Wilson Noleto, Ivana Alencar Svenson Ramos, Julierme Ferreira Rocha, Idelmo Rangel Garcia, Berthiene M Salvador Roberto* Annals of Maxillofacial Surgery 2016 6(1):125-129 Tertiary hyperparathyroidism (HPT) is a rare condition that affects patients with secondary HPT, which develop hyperplasia of the parathyroid glands, thus causing an increase in parathyroid hormone levels. Bone alterations are the main consequences of this condition including the development of osteolytic lesions called brown tumor. This article reports an unusual case of brown tumors located in the maxilla a... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 1: History, subdivisions, and data
*Kurt-W Bütow, Roger Arthur Zwahlen, Jean A Morkel, Sharan Naidoo* Annals of Maxillofacial Surgery 2016 6(1):31-34 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in scientific literature related to history, c... περισσότερα »
Metastatic clear cell variant of renal cell carcinoma of the mandible: Review and case report
*Ajaz Shah, Shahi Jahan, Latief Najar, Shahid Hassan, Manzoor Mohammad* Annals of Maxillofacial Surgery 2016 6(1):144-147 A case of metastatic renal cell carcinoma (RCC) to the mandible is reported. A 22-year-old man consulted us for hypoesthesia of the right lower lip. Panorama X-ray film showed a radiolucent lesion in the right mandibular body. A diagnosis of a metastatic tumor to the mandible from the right kidney was made after evaluation by computed tomography and bone scan with Tc99 methyl diphosphonate which also revealed multiple bone metastases. Histologically diagnosis was... περισσότερα »
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Postoperative pain is a remaining issue in tonsillectomy. Polyglycolic acid (PGA) is a biocompatible material used for absorbent suture reinforcement, and its sheet has been applied for covering defects after resection of oral carcinoma. The aim of this study is to examine whether the attachment of a PGA sheet to surgical wounds would reduce posttonsillectomy […]
Cricohyoidoepiglottopexy in Laryngeal Trauma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
http://ift.tt/2a7TaTJ http://ift.tt/29uO2fs
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age […]
Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
We evaluated the efficacy of interpositional auricular cartilage grafting for perforation with an endoscopic endonasal approach via a mucosal regeneration technique. In total, 12 patients with symptomatic septal perforations were operated on by way of an endoscopic endonasal approach after an adequately sized cartilage graft was harvested. The graft was inserted between the circumferentially incised […]
Topical IL-7-Fc recruits the vaccine-induced CD8 T cells
Purpose: The induction of tissue-localized virus-specific CD8 T cells response is essential for the development of an effective therapeutic vaccine against genital diseases, such as cervical cancer and genital herpes. Here, we aimed to elucidate the immunological role of Interleukin-7 (IL-7) in the induction of mucosal cellular immunity. Experimental Design: IL-7 was engineered through Fc-fusion to enhance mucosal delivery across the genital epithelial barrier. The immunomodulatory role of IL-7 was evaluated by monitoring the kinetics of various immune cells and measuring the expr... περισσότερα »
Assessment of ALT and DAXX/ATRX in PanNETs
Purpose: Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms with increasing incidence and unpredictable behavior. Whole exome sequencing has identified recurrent mutations in the genes DAXX and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT). Both ALT and DAXX/ATRX loss were initially reported to be associated with a favorable prognosis; however, recent studies suggest the contrary. Our aims were to assess the prevalence and prognostic significance of ALT and DAXX/ATRX in both primary and metastatic... περισσότερα »
Physical Activity and Cancer: A Precision Medicine Approach
There is increasing interest in applying a precision medicine approach to understanding exercise as a potential treatment for cancer. We aimed to inform this new approach by appraising epidemiologic literature relating post-diagnosis physical activity to cancer outcomes overall and by molecular/genetic subgroups. Across 26 studies of breast, colorectal and prostate cancer patients, there was a 37% reduction in risk of cancer-specific mortality, comparing the most versus the least active patients (pooled relative risk=0.63, 95% confidence interval: 0.54-0.73). Risks of recurrence o... περισσότερα »
FDA Approval Summary: Palbociclib
On February 19th, 2016, the U.S. Food and Drug Administration (FDA) approved palbociclib (Ibrance, Pfizer) for use in combination with fulvestrant (Faslodex, AstraZeneca) for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer (MBC) with disease progression following endocrine therapy. The approval was based on the results of a randomized, double-blind, placebo-controlled trial conducted in 521 pre- and postmenopausal women with HR-positive, HER2-negative advanced or MBC. Patients... περισσότερα »
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up
In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age of 5 years (mean age, 23.3 years) with a pathologic diagnosis of micro-MTC without nodal involvement were enrolled. All patients underwent TT with thymectomy and central compartment lymph node dissection. During surgery, parathyr... περισσότερα »
Asian Targeted Temperature Management Task Panel Report
Therapeutic Hypothermia and Temperature Management , Vol. 0, No. 0. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29w2XCi
Success rate of implants placed in autogenous bone blocks versus allogenic bone blocks: A systematic literature review
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Saeed Reza Motamedian, Moein Khojaste, Arash Khojasteh* Annals of Maxillofacial Surgery 2016 6(1):78-90 The aim of this study is to review and compare survival/success rate of dental implants inserted in autogenous and allogenic bone blocks (ALBs). A PubMed search was performed from January 1990 to June 2014 limited to English language and human studies. Studies that reported treatment outcome of implants inserted in augmented alveolar ridges with autogenous or ALBs were included. Primary search identified 470 studies. For autogenous bone block (ABB) 36 articles and for ALB 23 arti... περισσότερα »
Primary rhinocheiloplasty: Comparison of open and closed methods of alar cartilage reposition
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*SA Yasonov, AV Lopatin, A Yu Kugushev* Annals of Maxillofacial Surgery 2016 6(1):21-24 Aims: To establish which rhinoplasty method for primary repairing of unilateral cleft lip (UCL) is better. Settings and Design: Two patient groups with cleft lip were compared. Each group was operated on either by McComb's technique as closed rhinoplasty method or by Vissarionov–Kosin technique as an open method. Subjects and Methods: First group included 29 patients and the second consisted of 31. All patients were operated on by single surgeon over 10 years. Randomization was based on wishes an... περισσότερα »
Zurich pediatric distractor for ramal condylar unit distraction in temporomandibular joint ankylosis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Brig N.K Sahoo, ID Roy, Rohit Sharma, Maj Preeti Kaur* Annals of Maxillofacial Surgery 2016 6(1):101-104 Temporomandibular joint (TMJ) Ankylosis is an extremely disabling condition characterized by difficulty or inability to open the mouth resulting in facial asymmetry, malocclusion and dental problems. Surgical excision of the ankylosed mass is the only treatment option available to gain mouth opening. The loss in vertical height of ramus following release of ankylosis is difficult to manage in both unilateral and bilateral TMJ ankylosis. Out of all the methods to restore this hei... περισσότερα »
Intermaxillary fixation screws versus Erich arch bars in mandibular fractures: A comparative study and review of literature
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Ahtesham Ahmad Qureshi, Umesh K Reddy, NM Warad, Sheeraz Badal, Amjad Ali Jamadar, Nilofar Qurishi* Annals of Maxillofacial Surgery 2016 6(1):25-30 Objective: Various techniques have been employed from time to time to achieve maxillomamdibular fixation. Although arch bars provide an effective and versatile means of maxillomandibular fixation, their use is not without shortcomings. However the introduction of intermaxillary fixation screws (IMF) has eliminated many of these issues of arch bars. The aim of the present study was to compare the advantages and disadvantages of intermax... περισσότερα »
A rare case of regression of brown tumors of tertiary hyperparathyroidism after parathyroidectomy and renal transplant: A 5-year follow-up
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*José Wilson Noleto, Ivana Alencar Svenson Ramos, Julierme Ferreira Rocha, Idelmo Rangel Garcia, Berthiene M Salvador Roberto* Annals of Maxillofacial Surgery 2016 6(1):125-129 Tertiary hyperparathyroidism (HPT) is a rare condition that affects patients with secondary HPT, which develop hyperplasia of the parathyroid glands, thus causing an increase in parathyroid hormone levels. Bone alterations are the main consequences of this condition including the development of osteolytic lesions called brown tumor. This article reports an unusual case of brown tumors located in the maxilla a... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 1: History, subdivisions, and data
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Kurt-W Bütow, Roger Arthur Zwahlen, Jean A Morkel, Sharan Naidoo* Annals of Maxillofacial Surgery 2016 6(1):31-34 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in scientific literature related to history, c... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 2: Syndromic and nonsyndromic Pierre Robin sequence
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Kurt-W Bütow, Jean A Morkel, Sharan Naidoo, Roger Arthur Zwahlen* Annals of Maxillofacial Surgery 2016 6(1):35-37 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature, relating to history, clinic... περισσότερα »
Autotransplantation donor tooth site harvesting using piezosurgery
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Leena P Ylikontiola, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):75-77 Background: The harvesting of a tooth as a candidate for tooth autotransplantation requires that the delicate dental tissues around the tooth be minimally traumatized. This is especially so for the periradicular tissues of the tooth root and the follicular tissues surrounding the crown. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction in the harvesting of teeth for autotransplantation. Methods: A piezosurgical handpiece and its selection of tips we... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 3: Prevailing controversial theories related to Pierre Robin sequence
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Kurt-W Bütow, Roger Arthur Zwahlen, Jean A Morkel, Sharan Naidoo* Annals of Maxillofacial Surgery 2016 6(1):38-43 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to histor... περισσότερα »
Forgotten triangles of neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Manpreet Singh, Arpit Vashistha, Manoj Chaudhary, Gagandeep Kaur* Annals of Maxillofacial Surgery 2016 6(1):91-93 The purpose of this manuscript is to add some more information in the present scientific literature on these nearly forgotten triangles of surgical importance. The neck is an area that lends itself to anatomical geometry, such as triangles. Many triangles of the neck have been described, and some are well-known, yet, some have been nearly forgotten, i.e., Lesser's triangle, Farabeuf triangle, Pirogoff's triangle, and Beclard's triangle. From the anatomic and surgical po... περισσότερα »
Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 4: Recommended management and treatment of Pierre Robin sequence and its application
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Kurt-W Bütow, Sharan Naidoo, Roger Arthur Zwahlen, Jean A Morkel* Annals of Maxillofacial Surgery 2016 6(1):44-49 Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to histor... περισσότερα »
Altered intrinsic connectivity of the auditory cortex in congenital amusia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Congenital amusia, a neurodevelopmental disorder of music perception and production, has been associated with abnormal anatomical and functional connectivity in a right frontotemporal pathway. To investigate whether spontaneous connectivity in brain networks involving the auditory cortex is altered in the amusic brain, we ran a seed-based connectivity analysis, contrasting at-rest functional MRI data of amusic and matched control participants. Our results reveal reduced frontotemporal connectivity in amusia during resting state, as well as an overconnectivity between the auditory ... περισσότερα »
Strategies for targeting primate neural circuits with viral vectors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Understanding how the brain works requires understanding how different types of neurons contribute to circuit function and organism behavior. Progress on this front has been accelerated by optogenetics and chemogenetics, which provide an unprecedented level of control over distinct neuronal types in small animals. In primates, however, targeting specific types of neurons with these tools remains challenging. In this review, we discuss existing and emerging strategies for directing genetic manipulations to targeted neurons in the adult primate central nervous system. We review the ... περισσότερα »
Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
We reported previously that both transcutaneous electrical spinal cord stimulation and direct pressure stimulation of the plantar surfaces of the feet can elicit rhythmic involuntary step-like movements in noninjured subjects with their legs in a gravity-neutral apparatus. The present experiments investigated the convergence of spinal and plantar pressure stimulation and voluntary effort in the activation of locomotor movements in uninjured subjects under full body weight support in a vertical position. For all conditions, leg movements were analyzed using electromyographic (EMG) ... περισσότερα »
Voltage imaging to understand connections and functions of neuronal circuits
Understanding of the cellular mechanisms underlying brain functions such as cognition and emotions requires monitoring of membrane voltage at the cellular, circuit, and system levels. Seminal voltage-sensitive dye and calcium-sensitive dye imaging studies have demonstrated parallel detection of electrical activity across populations of interconnected neurons in a variety of preparations. A game-changing advance made in recent years has been the conceptualization and development of optogenetic tools, including genetically encoded indicators of voltage (GEVIs) or calcium (GECIs) and ... περισσότερα »
Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons
Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now describe the actions of two imidazolidinedione derivatives, AUT1 and AUT2, which modulate Kv3.1 channels. Using Chinese hamster ovary cells stably expressing rat Kv3.1 channels, we found that lower concentrations of these compounds shift the voltage of activation of Kv3.1 ... περισσότερα »
Frequency-specific insight into short-term memory capacity
The digit span is one of the most widely used memory tests in clinical and experimental neuropsychology for reliably measuring short-term memory capacity. In the forward version, sequences of digits of increasing length have to be reproduced in the order in which they are presented, whereas in the backward version items must be reproduced in the reversed order. Here, we assessed whether transcranial alternating current stimulation (tACS) increases the memory span for digits of young and midlife adults. Imperceptibly weak electrical currents in the alpha (10 Hz), beta (20 Hz), thet... περισσότερα »
Altered intrinsic connectivity of the auditory cortex in congenital amusia
Congenital amusia, a neurodevelopmental disorder of music perception and production, has been associated with abnormal anatomical and functional connectivity in a right frontotemporal pathway. To investigate whether spontaneous connectivity in brain networks involving the auditory cortex is altered in the amusic brain, we ran a seed-based connectivity analysis, contrasting at-rest functional MRI data of amusic and matched control participants. Our results reveal reduced frontotemporal connectivity in amusia during resting state, as well as an overconnectivity between the auditory ... περισσότερα »
Strategies for targeting primate neural circuits with viral vectors
Understanding how the brain works requires understanding how different types of neurons contribute to circuit function and organism behavior. Progress on this front has been accelerated by optogenetics and chemogenetics, which provide an unprecedented level of control over distinct neuronal types in small animals. In primates, however, targeting specific types of neurons with these tools remains challenging. In this review, we discuss existing and emerging strategies for directing genetic manipulations to targeted neurons in the adult primate central nervous system. We review the ... περισσότερα »
Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion
We reported previously that both transcutaneous electrical spinal cord stimulation and direct pressure stimulation of the plantar surfaces of the feet can elicit rhythmic involuntary step-like movements in noninjured subjects with their legs in a gravity-neutral apparatus. The present experiments investigated the convergence of spinal and plantar pressure stimulation and voluntary effort in the activation of locomotor movements in uninjured subjects under full body weight support in a vertical position. For all conditions, leg movements were analyzed using electromyographic (EMG) ... περισσότερα »
Resting-state functional connectivity differentiates anxious apprehension and anxious arousal
Abstract Brain regions in the default mode network (DMN) display greater functional connectivity at rest or during self-referential processing than during goal-directed tasks. The present study assessed resting-state connectivity as a function of anxious apprehension and anxious arousal, independent of depressive symptoms, in order to understand how these dimensions disrupt cognition. Whole-brain, seed-based analyses indicated differences between anxious apprehension and anxious arousal in DMN functional connectivity. Lower connectivity associated with higher anxious apprehension su... περισσότερα »
Unfavorable outcome of unilateral cleft lip repair
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*SM Balaji* Annals of Maxillofacial Surgery 2016 6(1):3-3 http://ift.tt/29NU8Zq
In situ vasculogenesis: The potential role of mesenchymal stem cells in craniofacial reconstruction
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Michael H Carstens* Annals of Maxillofacial Surgery 2016 6(1):1-2 http://ift.tt/29OkCa4
The use of superficial cervical plexus block in oral and maxillofacial surgical practice as an alternative to general anesthesia in selective cases
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*R Kamal Kanthan* Annals of Maxillofacial Surgery 2016 6(1):4-8 Aim: (1) To assess the feasibility, safety, and effectiveness of superficial cervical plexus (SCP) block in oral and maxillofacial surgical (OMFS) practice as an alternative to general anesthesia in selective cases. (2) To assess any associated complication specifically related to the procedure. Subjects and Methods: The total number of patients was 10, out of which 6 were male and 4 were female patients. Six patients had incision and drainage of perimandibular space infections, two patients had Level Ib cervical lym... περισσότερα »
The use of a dynamic real-time jaw tracking device and cone beam computed tomography simulation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Shushu He, Chung How Kau, Lina Liao, Keith Kinderknecht, Andrew Ow, Tayem Abou Saleh* Annals of Maxillofacial Surgery 2016 6(1):113-119 Background: The aim was to introduce and preliminarily evaluate a new software application, SICAT Function, which can directly combine and merge three-dimensional cone beam computed tomography (CBCT) and electronic SICAT jaw motion tracking (JMT) data. Methods: A detailed description of the methods and dynamic clinical simulation of mandibular movements of a patient are demonstrated. Functional jaw movements on 3 days were recorded by JMT tracki... περισσότερα »
Radiographic and histological evaluation of ectopic application of deproteinized bovine bone matrix
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Rodrigo Carlos da Silva, Viviane Rozeira Crivellaro, Allan Fernando Giovanini, Rafaela Scariot, Carla Castiglia Gonzaga, João César Zielak* Annals of Maxillofacial Surgery 2016 6(1):9-14 Objective: To evaluate, through radiographic and histological analysis, the tissue reaction induced by a biomaterial based on deproteinized bovine bone matrix (DBBM) in the muscle of sheep. sMaterials and Methods: Sixteen sheep were used. The animals underwent surgery to insert polyethylene tubes containing the biomaterial in the muscle of the lower back (ectopic site) and were euthanized after 3... περισσότερα »
Piezo harvesting of bone grafts from the anterior iliac crest: A technical note
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Leena P Ylikontiola, Ville Lehtonen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):94-96 Background: Autogenous bone graft harvesting from the iliac crest is associated with donor site morbidity. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction. Materials and Methods: A piezosurgical handpiece and its selection of tips can easily be accommodated in an iliac crest wound to osteotomize and allow the harvest and delivery of autogenous bone grafts. Results: Corticocancellous blocks or cancellous strips of autogenous bone ... περισσότερα »
Large ameloblastic fibro-odontoma in a 7-year-old girl with analysis of 108 cases
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Antti Kirjavainen, Veikko Tuovinen, George K Sándor* Annals of Maxillofacial Surgery 2016 6(1):15-20 Background: Odontogenic tumors such as ameloblastic fibro-odontoma (AFO) are rare conditions in children and are often asymptomatic. AFOs are found by routine clinical and radiological examination or when they cause obvious intra- or extra-oral swelling. Materials and Methods: A case of an AFO in a 7-year-old girl is described, and 107 cases from the literature and this report are analyzed. Results: The total of 108 cases revealed the average age at presentation of AFO to be 6.3 y... περισσότερα »
Crouzon syndrome: Virtual planning of surgical treatment by application of internal distractors
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Chingiz Rahimov, Ruslan Asadov, Gunel Hajiyeva, Nazim Verdiyev, Zaur Novruzov, Ismayil Farzaliyev* Annals of Maxillofacial Surgery 2016 6(1):135-140 Crouzon syndrome is one of the frequent pathologies within craniosynostosis syndrome. Current progress in computers and biotechnologies allows improving surgical approach and forecasting final result of reconstruction as well. We present a case of successful surgical treatment of Crouzon syndrome, done by application of virtual planning allowing determining “monobloc” features, type of reconstruction and distraction protocol as well... περισσότερα »
Primary rhinocheiloplasty: Comparison of open and closed methods of alar cartilage reposition
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*SA Yasonov, AV Lopatin, A Yu Kugushev* Annals of Maxillofacial Surgery 2016 6(1):21-24 Aims: To establish which rhinoplasty method for primary repairing of unilateral cleft lip (UCL) is better. Settings and Design: Two patient groups with cleft lip were compared. Each group was operated on either by McComb’s technique as closed rhinoplasty method or by Vissarionov–Kosin technique as an open method. Subjects and Methods: First group included 29 patients and the second consisted of 31. All patients were operated on by single surgeon over 10 years. Randomization was based on wishes ... περισσότερα »
Success rate of implants placed in autogenous bone blocks versus allogenic bone blocks: A systematic literature review
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Saeed Reza Motamedian, Moein Khojaste, Arash Khojasteh* Annals of Maxillofacial Surgery 2016 6(1):78-90 The aim of this study is to review and compare survival/success rate of dental implants inserted in autogenous and allogenic bone blocks (ALBs). A PubMed search was performed from January 1990 to June 2014 limited to English language and human studies. Studies that reported treatment outcome of implants inserted in augmented alveolar ridges with autogenous or ALBs were included. Primary search identified 470 studies. For autogenous bone block (ABB) 36 articles and for ALB 23 ar... περισσότερα »
Intermaxillary fixation screws versus Erich arch bars in mandibular fractures: A comparative study and review of literature
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Ahtesham Ahmad Qureshi, Umesh K Reddy, NM Warad, Sheeraz Badal, Amjad Ali Jamadar, Nilofar Qurishi* Annals of Maxillofacial Surgery 2016 6(1):25-30 Objective: Various techniques have been employed from time to time to achieve maxillomamdibular fixation. Although arch bars provide an effective and versatile means of maxillomandibular fixation, their use is not without shortcomings. However the introduction of intermaxillary fixation screws (IMF) has eliminated many of these issues of arch bars. The aim of the present study was to compare the advantages and disadvantages of interm... περισσότερα »
Zurich pediatric distractor for ramal condylar unit distraction in temporomandibular joint ankylosis
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
*Brig N.K Sahoo, ID Roy, Rohit Sharma, Maj Preeti Kaur* Annals of Maxillofacial Surgery 2016 6(1):101-104 Temporomandibular joint (TMJ) Ankylosis is an extremely disabling condition characterized by difficulty or inability to open the mouth resulting in facial asymmetry, malocclusion and dental problems. Surgical excision of the ankylosed mass is the only treatment option available to gain mouth opening. The loss in vertical height of ramus following release of ankylosis is difficult to manage in both unilateral and bilateral TMJ ankylosis. Out of all the methods to restore this h... περισσότερα »
