Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 17 Μαΐου 2018

NonScarring Diffuse Hair Loss in Women: a Clinico‐Etiological Study from tertiary care center in North‐West India

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2IPhltR

Violaceous papules on the hands

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2wR9MOv

A simple and cost‐efficient adherent culture platform for human gastric primary cells, as an in vitro model for Helicobacter pylori infection

Helicobacter, EarlyView.


https://ift.tt/2L5DXot

Facial Fractures as a Result of Falls in the Elderly: Concomitant Injuries and Management Strategies

Cranial Maxillofac Trauma Reconstruction
DOI: 10.1055/s-0038-1642034

Mechanical falls are a common cause of facial trauma in the elderly population. It has been shown that the likelihood of sustaining a facial fracture due to a fall or activities of daily life significantly increases with age. Craniomaxillofacial fractures are most common during the first three decades of life; however, elderly patients more frequently require lengthy hospital stays and surgical intervention, and have shown increased complication rates compared with younger patients. The objective of this study was to examine the prevalence of facial fractures secondary to mechanical falls in the elderly population to analyze mechanism of injury, comorbidities, and fracture management. A retrospective review of all facial fractures as a result of falls in the elderly population in a level 1 trauma center in an urban environment was performed for the years 2002 to 2012. Patient demographics were collected, as well as location of fractures, concomitant injuries, and surgical management strategies. During the time period examined, 139 patients were identified as greater than 60 years of age and having sustained a fracture of the facial skeleton as the result of a fall. The average age was 75.7 (range, 60–103) years, with no gender predominance of 50.4% female and 49.6% male. There were a total of 205 fractures recorded. The most common fractures were those of the orbit (42.0%), nasal bone (23.4%), zygoma (13.2%), and zygomaticomaxillary complex (7.32%). The average Glasgow Coma Scale on arrival was 12.8 (range, 3–15). Uncontrolled hemorrhage was noted on presentation to the trauma bay in five patients. Twenty-one patients were intubated on, or prior to, arrival to the trauma bay, and 44 required a surgical airway. The most common concomitant injury was a long bone fracture (23.5%), followed by cervical spine fracture (18.5%), skull fracture (17.3%), intracerebral hemorrhage (17.3%), rib fracture (17.3%), ophthalmologic injuries (6.2%), short bone fracture (4.9%), pelvic fracture (2.9%), thoracic spine fracture (1.2%), and lumbar spine fracture (1.2%). Of the 114 patients admitted to the hospital, 53 were admitted to an intensive care setting. The average hospital length of stay was 8.97 days (range, 0–125). Sixteen patients expired. Surgical management of fractures in the operating room was required in 47 of the 139 patients. Of the patients treated, 36.2% required an open reduction and internal fixation procedure. Facial fractures as a result of falls in the geriatric population represent an increasing number of cases in clinical practice as life expectancy steadily rises. These patients require a specific standard of treatment since they are more susceptible to nosocomial infections, as well as have higher complication rates and longer recovery time. Concomitant injuries such as cervical spine and pelvic fractures can greatly increase risk of mortality. Surgical and soft tissue management must be approached with caution to optimize function and aesthetics while preventing secondary infection. The authors hope that this study can provide some insight and further investigation as there is a dearth of literature to the management of facial fractures in falls in elderly patients.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2wOUTMN

Aesthetic Nasal Reconstruction Principles and Practice

Cranial Maxillofac Trauma Reconstruction
DOI: 10.1055/s-0038-1645865



Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2rOSYTl

Kardioanästhesie: Monitoring und aktuelle hämodynamische Konzepte

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 332-345
DOI: 10.1055/s-0043-106281

Die Krankheitsschwere herzchirurgischer Patienten und die Komplexität der Eingriffe haben in den letzten Jahren deutlich zugenommen. Dies stellt nicht nur erhöhte Anforderungen an die neurologische und hämodynamische Überwachung, sondern macht es auch erforderlich, die hämodynamische Therapie – unter Berücksichtigung aktueller pharmakologischer Entwicklungen – individuell dem höheren Risikoprofil der Patienten anzupassen.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2rOL4JF

Kasuistik: Metamizol-induzierte Agranulozytose

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 388-394
DOI: 10.1055/s-0043-115329

Metamizol hat insgesamt ein günstiges Nebenwirkungsprofil – aber es birgt ein höheres Risiko einer medikamenteninduzierten Agranulozytose als andere Schmerzmittel und darf daher nicht unkritisch eingesetzt werden. Dieser Beitrag berichtet von einem Patienten, der nach prothetischem Hüftersatz eine medikamenteninduzierte Agranulozytose – mutmaßlich durch Metamizol – entwickelt und trotz maximaler Therapie im septischen Schock verstirbt.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2INqhjI

Intensivmedizin: Ist ein hohes CRP ein geeigneter Prädiktor für ein postoperatives Delir?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 324-327
DOI: 10.1055/a-0607-6157



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2Gr1M6p

Kardioanästhesie: Monitoring der Gerinnung und Gerinnungstherapie

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 364-379
DOI: 10.1055/s-0043-112099

Die Transfusion von allogenen Blutprodukten ist mit einer Erhöhung der perioperativen Morbidität und Letalität assoziiert. Störungen der Hämostase sind insbesondere bei kardiochirurgischen Patienten häufig anzutreffen und können zu transfusionspflichtigen Blutungen führen. Eine zielgerichtete Therapie der häufig komplexen Gerinnungsstörungen erfordert eine differenzierte Diagnostik.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2INq00a

Kardioanästhesie 2018 – Wandel als Chance?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 329-330
DOI: 10.1055/a-0588-4274



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2ItTY5X

Hypertone Lösungen bei hämorrhagischem Schock ohne gesicherten Vorteil

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 327-328
DOI: 10.1055/a-0607-6183



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2Gr1HQ9

Kardioanästhesie: anästhesiologisches Management

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 346-362
DOI: 10.1055/s-0043-106337

Das anästhesiologische Management herzchirurgischer Patienten hat sich in den letzten Jahren deutlich weiterentwickelt. Diese Übersicht widmet sich vor allem folgenden Bereichen: pharmakologische Kardioprotektion bei herzchirurgischen Eingriffen, Narkosemanagement an der Herz-Lungen-Maschine, Protokolle der „Enhanced Recovery After Cardiac Surgery" sowie innovative minimalinvasive Operationsverfahren wie die kathetergestützte Aortenklappenimplantation.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2IvbFlF

Hypotonie nach Spinalanästhesie zur Sectio: Noradrenalin oder Phenylephrin?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 328-328
DOI: 10.1055/a-0607-6144



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2rOl1m2

Obere Altersgrenze bei ambulanter Anästhesie: Möglichkeiten und Risiken

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 380-386
DOI: 10.1055/s-0042-124408

Zahlreiche Operationen werden heute auch noch in höherem Lebensalter ambulant durchgeführt. Dieser Übersichtsartikel stellt die Vorteile der ambulanten Anästhesie bei älteren Patienten dar, zeigt aber auch die Risiken einer zu frühen Entlassung auf. Für den klinischen Alltag werden praktische Hilfestellungen für die Patientenauswahl gegeben und Risikofaktoren für eine ungeplante stationäre Aufnahme identifiziert.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2Gr1Gf3

Pssst … AINS-Secrets: heute aus der Urologie – TUR-Syndrom

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 395-398
DOI: 10.1055/s-0042-101662



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2IrF0gC

Erratum: Atemwegsmanagement – der schwierige Atemweg beim thoraxchirurgischen Patienten

Anästhesiol Intensivmed Notfallmed Schmerzther
DOI: 10.1055/a-0613-2898



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2rOL1gX

Sauerstoffgabe für die Mutter bei Kaiserschnitt und oxidativer Stress des Kindes

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 322-322
DOI: 10.1055/a-0607-6131



Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2INq2Fk

Interchangeability of counts of cases and hours of cases for quantifying a hospital's change in workload among four-week periods of 1 year

Recent studies have made longitudinal assessments of case counts using State (e.g., United States) and Provincial (e.g., Canada) databases. Such databases rarely include either operating room (OR) or anesthesia times and, even when duration data are available, there are major statistical limitations to their use. We evaluated how to forecast short-term changes in OR caseload and workload (hours) and how to decide whether changes are outliers (e.g., significant, abrupt decline in anesthetics).

https://ift.tt/2ItNynd

Supraglottoplasty in children with laryngomalacia: A review and parents' appraisal

To assess the parents' perspective concerning the children's clinical picture before and after supraglottoplasty for the treatment of laryngomalacia (LM).

https://ift.tt/2rWZDuj

Sentinel lymph node biopsy in cutaneous melanoma of the head and neck using the indocyanine green SPY Elite system

Lymph node status is the single most important prognostic factor for patients with early-stage cutaneous melanoma. Sentinel lymph node biopsy (SLNB) has become the standard of care for intermediate depth melanomas. Modern SLNB implementation includes technetium-99 lymphoscintigraphy combined with local administration of a vital blue dye. However, sentinel lymph nodes may fail to localize in some cases and false-negative rates range from 0 to 34%. Here we demonstrate the feasibility of a new sentinel lymph node biopsy technique using indocyanine green (ICG) and the SPY Elite near-infrared imaging system.

https://ift.tt/2k8KEd4

Nasolabial aesthetics of patients with repaired unilateral cleft lip and palate: A comparison of three rating methods in two countries

The study aimed to compare nasolabial aesthetics of patients with unilateral cleft lip and palate (UCLP) treated in Vietnam and Estonia using three rating methods: five-point aesthetic index, a visual analogue scale (VAS), and reference scores method.

https://ift.tt/2k7Aycx

The effect of mandibular distraction osteogenesis on airway obstruction and polysomnographic parameters in children with Robin sequence

The optimal surgical technique for the management of patients with Robin Sequence (RS) has not been established. One of the most commonly used surgical techniques, mandibular distraction osteogenesis (MDO), is still controversial because of its potential risks and the lack of clear evidence of its efficacy.

https://ift.tt/2rQWTOO

Minimally-invasive biomarker studies in eosinophilic esophagitis: a systematic review

Publication date: Available online 10 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Brittany T. Hines, Matthew A. Rank, Benjamin L. Wright, Lisa A. Marks, John B. Hagan, Alex Straumann, Matthew Greenhawt, Evan S. Dellon
BackgroundEosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus which currently requires repeated endoscopic biopsies for diagnosis and monitoring as no reliable non-invasive markers have been identified.ObjectiveTo identify promising minimally-invasive EoE biomarkers and remaining gaps in biomarker validation.MethodsWe performed a systematic review of EMBASE, Ovid Medline, PubMed, and Web of Science from inception to June 6, 2017. Studies were included if subjects met the 2007 consensus criteria for EoE diagnosis, a minimally-invasive biomarker was assessed, and the study included at least 1 control for comparison.ResultsThe search identified 2094 studies, with 234 reviewed at full text level, and 49 included in the analysis (20 adult, 19 pediatric, 7 pediatric and adult, and 3 not stated). The majority (26 of 49) were published after 2014. Thirty-five studies included normal controls, 9 analyzed atopic controls, and 29 compared samples from subjects with active and inactive EoE. Minimally-invasive biomarkers were obtained from peripheral blood (n=41 studies), sponge/string samples (3), oral/throat swab secretions (2), breath condensate (2), stool (2), and urine (2). The most commonly reported biomarkers were peripheral blood eosinophils (16), blood and string eosinophil granule proteins (14), and eosinophil surface or intracellular markers (12). EoE biomarkers distinguished active EoE from normal controls in 23 studies, atopic controls in 2 studies, and inactive EoE controls in 20 studies.ConclusionSeveral promising minimally-invasive biomarkers for EoE have emerged; however, few are able to differentiate EoE from other atopic diseases.



https://ift.tt/2rQRfwi

Medical and dietary management of eosinophilic esophagitis

Publication date: Available online 10 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Quan M. Nhu, Seema S. Aceves
ObjectiveEosinophilic esophagitis (EoE) is a disease of chronic, allergen-driven, T-helper 2 (Th2) immune-mediated inflammation that progresses to fibrostenosis of the esophagus if left untreated. There are currently no FDA-approved drugs for the treatment of EoE. This review focuses on medical and dietary management of EoE.Data SourcesManuscripts on EoE treatments are identified on PubMed.Study SelectionsOriginal research, randomized control trials, retrospective studies, meta-analyses, case series, and on occasions, case reports of high relevance, are selected and reviewed.ResultsCurrent treatment strategies available to EoE patients center on monotherapy or combination therapy with dietary modification to exclude antigenic stimulation and topical corticosteroids to control Th2-mediated tissue inflammation and pathologic remodeling. Dilation as a rescue therapy for the narrowed, fibrostenotic, symptomatic esophagus can potentially be avoided with optimal medical and elimination diet therapies. The molecular mechanisms underlying EoE pathogenesis are being unraveled, from which targeted therapies can be developed and evaluated in pre-clinical and clinical studies. Current clinical research efforts focus on optimization of topical corticosteroid delivery, dosing, frequency, and duration of treatment, either alone or in combination with tailored elimination diet. Preliminary clinical trials with biologics targeting IL-5 and IL-13/IL-4 have been completed.ConclusionsTopical corticosteroid, elimination diet, and dilation are the current treatment modalities for confirmed EoE. The use of proton-pump inhibitors (PPI) is being suggested as a potential regimen to treat EoE, based on evolving understanding of PPI-responsive esophageal eosinophilia (PPI-REE). The complexity of EoE treatment regimens and frequent follow ups require a multimodal, multi-disciplinary management approach to optimize patient care.



https://ift.tt/2k7PPKq

Efficacy of a single dose of omalizumab for the prevention of ethylene oxide intraoperative anaphylaxis

Publication date: Available online 16 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Maria Beatrice Bilò, Alice Corsi, M. Feliciana Brianzoni, M. Stella Garritani, Leonardo Antonicelli




https://ift.tt/2KuDyuo

Successful treatment switch from lenvatinib to sorafenib in a patient with radioactive iodine-refractory differentiated thyroid cancer intolerant to lenvatinib due to severe proteinuria

Sorafenib and lenvatinib showed efficacy for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) in pivotal phase 3 clinical trials. Although the efficacy of lenvatinib in patients who received previous treatment with multi-target kinase inhibitors (m-TKIs), including sorafenib, was reported, the efficacy of sorafenib in patients who previously received lenvatinib remains unknown. A 75-year-old woman diagnosed as RAI-refractory poorly differentiated carcinoma with multiple lung metastases and started treatment with lenvatinib.

https://ift.tt/2IpTAt5

Plasmacytoma

Dear Editor,

https://ift.tt/2KztOPO

Osteoblastoma of the mandible: A rare locally aggressive benign tumour

Dear Editor,

https://ift.tt/2k4tuNH

Aging in the United States

The number of Americans over the age of 65 has been growing much faster than the overall population's growth rate. These changes can be largely attributed to the improvement in life expectancy. This demographic shift yields a unique and exciting opportunity to provide both expedient and cost-efficient care to a growing patient population.

https://ift.tt/2rWQMc3

Dysphagia in the Older Patient

Dysphagia in older adults is a challenging problem and necessitates a team approach. The key to effective management is recognition. Patients tend to dismiss their symptoms as normal aging; therefore, early diagnosis depends on the diligence of the primary care doctors. No diagnostic technique can replace the benefits of a thorough history, with a detailed understanding of nutritional status and aspiration risk. Although one of the main goals in management is to ensure safe swallowing, the impact of a nonoral diet on the quality of life of patients should not be underestimated.

https://ift.tt/2IqnLR5

Sleep Apnea and Sleep-Disordered Breathing

Older adults undergo gradual changes in their sleep patterns. It is important to differentiate normal age-related sleep changes from sleep disorders. Because sleep disorders can impact an older adult's day-to-day life and contribute to various comorbidities, these patients should be carefully screened by using a detailed medical history, combined with a detailed sleep history. There is a high prevalence of undiagnosed and untreated sleep apnea in the elderly. Early identification and appropriate management of this disorder may not only provide improvement in quality of life but also decrease disease-associated morbidity and mortality.

https://ift.tt/2rR4CMN

The Emerging Field of Geriatric Otolaryngology

Sub-specialization within otolaryngology, like other specialties, is driven by accumulation of new knowledge and technology. For a variety of reasons, the establishment of a new subspecialty of geriatric otolaryngology is unlikely. Education of all otolaryngologists in the basic principles of gerontology and geriatric otolaryngology is achievable and represents a preferred strategy.

https://ift.tt/2IpFuI9

Facial Plastic Surgery in the Geriatric Population

Greater life expectancy with advancements in technology and medicine has led to an increasing interest in facial rejuvenation. Facial aging is an inevitable process that largely results from soft tissue descent and volumetric deflation. However, a comprehensive knowledge of the aging process and precise assessment of the exact pathologies yielding the patient's senescent appearance is essential to produce the best cosmetic outcome. The surgeon must evaluate each region independently and the aging face as a whole to ensure a pleasing, natural appearance.

https://ift.tt/2GrQ23J

Treating the Elderly with Science and Dignity

Just as children are not simply small adults, elderly individuals have medical needs that may not be satisfied by just translating medical knowledge from younger adults. Geriatric medicine deals exclusively with the health and diseases of the elderly, including many issues that affect them primarily due to the aging of organs over time, such as cataracts, dementia, and presbycusis, among others. A challenge in this population is that care of one problem must include consideration of a multitude of parameters, including coexistent illnesses and polypharmacy, for better decision making.

https://ift.tt/2IpFfwJ

Targeted delivery of CD44s-siRNA by ScFv overcomes de novo resistance to cetuximab in triple negative breast cancer

Publication date: July 2018
Source:Molecular Immunology, Volume 99
Author(s): Wenyan Fu, Hefen Sun, Yang Zhao, Mengting Chen, Lipeng Yang, Xueli Yang, Wei Jin
The overexpression of EGFR often occurs in TNBC, and the anti-EGFR receptor antibody cetuximab is used widely to treat metastatic cancer in the clinic. However, EGFR-targeted therapies have been developed for TNBC without clinical success. In this study, we show that impaired EGFR degradation is crucial for resistance to cetuximab, which depends on the cell surface molecule CD44. To further investigate the role of CD44 in EGFR signaling and its treatment potential, we developed a targeting fusion protein composed of an anti-EGFR scFv generated from cetuximab and truncated protamine, called Ce-tP. CD44 siRNA can be specifically delivered into EGFR-positive TNBC cells by Ce-tP. Efficient knockdown of CD44 and suppression of both EGFR and downstream signaling by the Ce-tP/siRNA complex were observed in EGFR-positive TNBC cells. More importantly, our results also showed that targeted delivery of siRNA specific for CD44 can efficiently overcome resistance to EGFR targeting in TNBC cells both in vitro and in vivo. Overall, our results establish a new principle to achieve EGFR inhibition in TNBC and limit drug resistance.



https://ift.tt/2IrC03T

Web-based information on oral dysplasia and precancer of the mouth – Quality and readability

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
ObjectivesThe numbers of individuals with oral cancer are increasing. This cancer is preceded by oral epithelial dysplasia (OED). There remains no detailed study of the online information presently available for patients with OED or indeed what information such patients may require to be appropriately informed regarding their condition. Hence, the aim of the present study is to assess the patient-oriented web content with respect to OED.MethodsThe first 100 websites yielded from nine searches performed using different search terms and engines were considered. These were assessed for content, quality (DISCERN instrument, Journal of the American Medical Association benchmarks, and Health on Net seal) and readability (Flesch Reading Ease Score and Flesch-Kincaid Grade Level).ResultsThere was a general scarcity of OED content across the identified websites. Information about authors, sources used to compile the publication, treatment, and shared decision were limited or absent. Only 6% and 27% of the websites achieved all the four JAMA benchmarks and HON seal, respectively. The average readability level was at 10th grade (US schools), which far exceeds the recommended levels of written health information.ConclusionAt present patients seeking information on OED are likely to have difficulty in finding reliable information from the Web about this disorder and its possible impact upon their life. Further work is thus required to develop a web-based resource regarding OED that addresses the shortfalls demonstrated by the current study.



https://ift.tt/2IOOjdW

Valproate-induced hyperammonemia - uncovering an underlying inherited metabolic disorder: a case report

Sodium valproate is a commonly used anticonvulsant. It is widely recognized that valproate can cause hyperammonemia, particularly in people with underlying liver disease. Patients with urea cycle disorders are...

https://ift.tt/2rQFciA

The Voice and the Larynx in Older Adults—What’s Normal, and Who Decides?

Voice problems in older adults are common, with estimated prevalences of up to 30% across various samples and query methodologies. Age-related changes of laryngeal anatomy and physiology are thought to lead to both presbylaryngis and dysphonia, but many patients with findings of presbylaryngis are asymptomatic, and the incidence of presbylaryngis remains incompletely understood. A challenge in management of voice disorders in older adults is thus what to consider normal vs pathologic, particularly in the context of presbylaryngis.

https://ift.tt/2IM8U2C

Clinical and Social Factors That Distinguish Presbylaryngis From Pathologic Presbyphonia

This cohort study determines what distinguishes pathologic presbyphonia from presbylaryngis in any adults older than 74 years.

https://ift.tt/2IwBWzJ

Patient-Specific, 3-Dimensionally Printed Endoscopic Sinus and Skull Base Surgical Model

This study describes the development and assessment of 3-dimensionally printed sinus and skull base models for use in endoscopic skull base surgery.

https://ift.tt/2rONZlE

The Role of Otolaryngologists in Eradicating Human Papillomavirus

This Viewpoint discusses the low rates of vaccination for human papillomavirus in the United States and the role that otolaryngologists can play in improving public health policy about this vaccination.

https://ift.tt/2Ira7J3

Postoperative Facial Baroparesis While Flying

This case report describes a unique iatrogenic mechanism of baroparesis in a patient who underwent surgical treatment of a facial nerve schwannoma.

https://ift.tt/2GkiQjm

A Novel Approach to the National Resident Matching Program

This Viewpoint details a star system for matching otolaryngology–head and neck surgery applicants with programs.

https://ift.tt/2uvZjam

May 2018 Issue Highlights



https://ift.tt/2wPCQWM

Risk Factors for Complication After Pediatric Tonsillectomy

This cohort study examines the association between posttonsillectomy complication rate and the age and weight of the child at the time of surgery.

https://ift.tt/2IsCOpz

Multidisciplinary Clinical Treatment of Head and Neck Cancer—Reply

In Reply We thank Mark and colleagues for recognizing our publication and for their shared dedication to improving cancer care. We find their results in the field of prostate cancer to be quite interesting, particularly their findings regarding a survival benefit in patients with access to a multidisciplinary clinic (MDC) treatment model. Likewise, we plan to investigate potential survival benefits in our own head and neck cancer MDC treatment model once we have accrued sufficient patient volumes and follow-up time. Recent retrospective studies in head and neck cancer have identified survival benefits in patients with access to multidisciplinary evaluations in particular subsites. It will be valuable to see if we also find this site-specific advantage in our own MDC population. Again, we thank the writers for their supportive response and for their efforts to optimize complex cancer care.

https://ift.tt/2IvtrWk

Analysis of Vocal Fold Motion Impairment in Neonates Undergoing Congenital Heart Surgery

This cross-sectional analysis evaluates the cost, postprocedure length of stay, and outcomes for neonates with vocal fold motion impairment after congenital heart surgery.

https://ift.tt/2IuiNyK

Survival in Surgically Treated Pediatric Head and Neck Sarcomas

This study investigates the role of facility and system factors associated with survival in pediatric patients with head and neck sarcomas.

https://ift.tt/2HwRfsG

Self-reported Hearing Difficulty and Risk of Accidental Injury in Adults

This cross-sectional analysis examines 2007 to 2015 data from the National Health Interview Survey to assess the association of hearing difficulty with risk of accidental injury in US adults.

https://ift.tt/2G5lN2Y

Hypercoagulability, Obstructive Sleep Apnea, and Pulmonary Embolism—Reply

In Reply We thank Dr Alonso-Fernández and colleagues for their interest in our recently published study titled, "Association Between Hypercoagulability and Severe Obstructive Sleep Apnea." The comments raised by the readers can be summarized in that a significant association exists between obstructive sleep apnea (OSA) and pulmonary embolism (PE), which can be another consequence of hypercoagulability in severe OSA.

https://ift.tt/2pvXqVp

Preoperative Facial Nerve Mapping and Pediatric Facial Vascular Anomaly Resection

This historically controlled study investigates if preoperative facial nerve mapping is associated with intraoperative facial nerve injury risk and safe surgical approach options compared with standard nerve integrity monitoring.

https://ift.tt/2uxnrcA

Errors in Items and Algorithm in Questionnaire for Validation Study

To the Editor We write to report a scoring algorithm error that was included in our article, "Development and Initial Validation of a Consumer Questionnaire to Predict the Presence of Ear Disease," published online on August 3, 2017, and in the October 2017 issue of JAMA Otolaryngology–Head & Neck Surgery. In this study, we examined the validity of the Consumer Ear Disease Risk Assessment (CEDRA), a questionnaire for the self-assessment of risk of ear diseases associated with hearing loss. The error was discovered by a member of our research team who was preparing a digital version of the questionnaire used in our study. The error occurred in the analysis code for 3 of the 28 questionnaire items included in the scoring (questions 16, 18, and 19). For these 3 questions, the 4-item rating scales were dichotomized incorrectly. After correcting the algorithm for these questions, we found slightly different results, without any differences in statistical significance of these results. The overall results and conclusions remain unchanged.

https://ift.tt/2FzlwIO

Thyroidectomy Practice After Implementation of 2015 American Thyroid Association Guidelines for Thyroid Carcinoma

This cohort study assesses surgical practice changes regarding lobectomy, up-front thyroidectomy, and completion thyroidectomy in a tertiary medical center before and after the implementation of the 2015 American Thyroid Association guidelines for well-differentiated thyroid carcinoma.

https://ift.tt/2GkiERa

Tubular Neck Mass

A man in his 60s had right-sided lateral neck pain; palpation demonstrated a mass running along the lateral border of the sternocleidomastoid (SCM) muscle and imaging showed an elongated enhancing tubular structure along the lateral surface of the right SCM muscle. What is your diagnosis?

https://ift.tt/2GiNR7x

Life Experience of Patients With Unilateral Vocal Fold Paralysis

This mixed methods study (surveys and interviews) promotes patient-centered care by characterizing the patient experiences of living with unilateral vocal fold paralysis.

https://ift.tt/2uLjrW1

Injested Fidget Spinner

This is the report of a case of a young woman with a complex mental health history including depression and eating disorder who presented with severe neck pain and vomiting after reporting ingestion of a fidget spinner toy broken into 3 pieces.

https://ift.tt/2FlLJrG

Single-Stage Mastoid Obliteration in Cholesteatoma Surgery

This systematic study analyzes the literature on recurrent and residual cholesteatoma rates after single-stage canal wall up and canal wall down tympanoplasty with mastoid obliteration.

https://ift.tt/2pgosjo

Hypercoagulability, Obstructive Sleep Apnea, and Pulmonary Embolism

To the Editor We read with great interest the article written by Hong et al. They found that prothrombin time in patients with obstructive sleep apnea (OSA) was shorter compared with controls, concluding that OSA might lead to a prothrombotic state, a probable contributing factor to the increase in cardiovascular complications in OSA, including ischemic heart disease and stroke. Observational studies suggest that suppression of apneas by continuous positive airway pressure (CPAP) may improve cardiovascular outcomes. Nevertheless, recent data from a large randomized clinical trial did not prevent cardiovascular events in patients with moderate-to-severe OSA, despite significant reduction in daytime sleepiness. One possible explanation is that they included patients with previous cardiovascular disease with an established atherosclerosis burden in arterial vessels and heart remodeling, which could be, by this time, unalterable by the CPAP effect.

https://ift.tt/2IGIHzs

An Aggressive Sinonasal Mass With Parameningeal Extension

A woman in her 60s presented with sinus pressure progressing to dental pain; imaging revealed a mass arising from the skull base and nasopharynx and involvement of the right posterior orbit. What is your diagnosis?

https://ift.tt/2Iu0nhG

Multidisciplinary Clinical Treatment of Head and Neck Cancer

To the Editor We commend the authors on their adoption of a multidisciplinary clinic (MDC) for the treatment of head and neck cancers and we agree with their conclusion that the cooperative treatment of cancer patients by relevant specialties is superior to a multiappointment approach. In their study, Townsend et al were able to show a significant decrease in treatment delays for patients from both the time of referral and following their first appointment with the team. We have had the same experience in our own MDC.

https://ift.tt/2pgcyGg

A Rare Cause of Oropharyngeal and Supraglottic Airway Narrowing

A man presented with right lower quadrant abdominal pain; imaging of the neck revealed a submucosal soft-tissue mass containing few punctate calcifications centered in the epiglottis narrowing of the oropharyngeal and supraglottic laryngeal airways by the enlarged epiglottis. What is your diagnosis?

https://ift.tt/2IJ7Yct

Radiomorphometric analysis of isolated zygomatic arch fractures: A comparison of classifications and reduction outcomes

Although different proposals have been made to categorize isolated zygomatic arch fractures (ZAF), an investigation about fracture type and clinical outcome has not been published. In this study, we analyzed the geometric fracture morphology in isolated ZAF and provide a survey of reduction outcomes in accordance with 4 independent classifications.

https://ift.tt/2k7aE8P

Incidence of diplopia after division and reattachment of the inferior oblique muscle during orbital fracture repair

Wide surgical access to the orbital floor and medial wall is often impaired by the course of the inferior oblique muscle. There is no current consensus on the optimal surgical approach for exposure, and techniques involving inferior oblique division are generally shunned for concern of possible complications.

https://ift.tt/2rQKCKj

A new three-dimensional, print-on-demand temporomandibular prosthetic total joint replacement system: Preliminary outcomes

The aim of this study is to present the preliminary clinical data on the OMX Temporomandibular Joint (TMJ) Prosthetic total joint replacement system.

https://ift.tt/2k3FyyJ

Effect of paracetamol/prednisolone versus paracetamol/ibuprofen on post-operative recovery after adult tonsillectomy

To compare the effect of Paracetamol/Prednisolone versus Paracetamol/Ibuprofen on post-operative recovery after adult tonsillectomy.

https://ift.tt/2IpZfzs

A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma

The main cause of primary hyperparathyroidism is a single parathyroid adenoma. Parathyroid lipoadenomas contain abundance of fat cells. Because of these histological features, they can mimic normal parathyroid tissue at the histopathologic examination and radiological imaging could be difficult to localize lipoadenomas.

https://ift.tt/2wNCpwj

From the pages of allergywatch July 2018

In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), type 2 inflammation and tissue eosinophilia suggest a poor prognosis, including increased postoperative recurrence risk. Recent studies have found that proton pump inhibitors (PPIs) can suppress production of the eosinophil chemoattractant eotaxin-3. The authors assessed the role of Th2 mediators in CRSwNP, along with the effects of eotaxtin 3 inhibition using PPIs.

https://ift.tt/2IvrQPE

Omalizumab can inhibit respiratory reaction during aspirin desensitization

Aspirin desensitization has been associated with benefit in management of aspirin exacerbated respiratory disease (AERD). An intervention that would encourage aspirin desensitization to be performed more frequently has substantial potential for improving outcomes and quality of life in patients with AERD.

https://ift.tt/2IJvx7M

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2IOqQJT

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2wNRz4q

Working while unwell: Workplace impairment in people with severe asthma

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2INPFFO

Threshold dose distribution for cashew nut allergy in children

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2Gr38hK

Management of pediatric orbital cellulitis: A systematic review

elsevier-non-solus.png

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Stephanie J. Wong, Jessica Levi
ObjectivesOrbital complications account for 74–85% of all complications from acute sinusitis, more often affect the pediatric population, and can result in devastating consequences. Therefore these patients require prompt diagnosis and proper management. We review and summarize the current literature to determine the appropriate management of each stage of pediatric orbital cellulitis and offer a new comprehensive literature-based algorithm.MethodsData sources were PubMed/MEDLINE, and Google Scholar. Studies relevant to the management of each subcategory of the Chandler criteria in the pediatric population, limited to the period 1997 through Jan 2018, were compiled and interpreted. Seventy-one studies were reviewed in total.ResultsPre-septal and post-septal cellulitis can generally be managed non-surgically, while orbital abscess and cavernous sinus thrombosis are managed surgically. For subperiosteal abscess, non-surgical medical management has been successful in certain patients. Results of the literature review were summarized, and subsequently developed into a comprehensive algorithm for management, including criteria for age, location, and volume of abscess on imaging.ConclusionsOrbital cellulitis, particularly subperiosteal abscesses, in children is not an absolute indication for immediate surgical intervention. Conservative measures can be safe and effective if appropriately used, depending on patient characteristics, clinical course, and imaging.



https://ift.tt/2IsBsux

Pediatric anosmia: A case series

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Leah J. Hauser, Emily L. Jensen, David M. Mirsky, Kenny H. Chan
IntroductionLittle is known about the etiology of olfactory dysfunction in the pediatric population. The aim of this study is to characterize the etiology and clinical features of anosmia and to explore evaluation options in a pediatric population.MethodsOlfactory dysfunction was identified at a tertiary pediatric hospital between January 2003 and October 2014 using a text-based and ICD-9 search of the electronic health record system. Clinical information gathered included history, physical examination and imaging study. A phone questionnaire was completed to determine persistence and development of other rhinologic, endocrine, or neurologic symptoms.Results37 children (male/female = 17/20) with mean/median ages of 13.28/14. 19 years were identified. The distribution of etiology was: rhinologic disease (N = 16), congenital (N = 4), trauma (N = 1), neoplasm (N = 1) and unknown (N = 15). Rhinologic disease included chronic rhinosinusitis (N = 3) and other nasal anatomic lesions. None of the four subjects with congenital anosmia had classic Kallmann syndrome. The utility of imaging in confirming an etiology of anosmia was noted in 1 of 8 CT and 5 of 22 MRI. The most significant finding of the questionnaire was confirmation of normal puberty in the congenital group.ConclusionSimilar to the adult population, rhinologic disease is the most common cause. Absence or hypoplasia of the olfactory bulbs without associated delayed puberty is the presentation of congenital anosmia in our cohort. MRI had a higher utility than CT in evaluating anosmia in general and congenital anosmia in specific. MRI to evaluate children with a history of congenital olfactory dysfunction is recommended.



https://ift.tt/2rOhkwP

Middle ear disease in Danish toddlers attending nursery day-care – Applicability of OM-6, disease specific quality of life and predictors for middle ear symptoms

elsevier-non-solus.png

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): J.H. Indius, S.K. Alqaderi, A.D. Kjeldsen, C.H. Heidemann
ObjectivesOtitis media (OM) is a very common childhood disease and impacts child quality of life (QoL) to different extends. The aim of this study was to investigate the difference in quality of life between three groups of children; Children with symptoms of ear disease within the last 4 weeks, children without any ear disease and children scheduled for ventilating tube treatment. Furthermore, we investigated predictors for experiencing middle ear symptoms. Lastly, we assessed psychometric properties of OM-6 used to assess QoL.MethodsFour hundred ninety-four children attending nursery day-care aged 6–36 months were enrolled in the study. Caregivers were asked to recall the child's history of symptoms related to middle ear infection. The Danish version of otitis media-6 questionnaire was used to measure the children's quality of life. Data from children treated with ventilating tubes were included from a previously published study. Logistic regression was applied for determining possible predictors for experiencing ear related symptoms.ResultsThe study had an 87% response rate, with a total of 342 children included. At the inclusion 32 (9%) children were included in the 4-week group and, while 307 children were allocated to the non-4 week group. The children in the 4-week group were significantly younger and were more likely to have siblings with a history of middle ear infection than the non-4week group. Furthermore, QoL was significantly worse in the 4-week group compared to the non-4week group. Only subtle differences were found between children with acute symptoms compared to children scheduled for tube treatment.ConclusionsAs expected, children with acute symptoms of OM experience lowered QoL compared to children with no symptoms and young age as well as having siblings with a history of middle ear problems were found to be possible predictors for experiencing middle ear symptoms. Children with acute symptoms differed from children scheduled for ventilating tubes on domains related to long-term problems from OM. OM-6 has shown to be a valid instrument for assessing disease specific QoL in children with OM, however a more large-scale instrument might be necessary for detecting subtle differences between subgroups of children with OM.



https://ift.tt/2IsBenb

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

International Journal of Osteoarchaeology, EarlyView.


https://ift.tt/2ItD6Mo

Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2L7uvRe

The role of Scalpel‐bougie cricothyroidotomy in managing emergency Front of Neck Airway access. A review and technical update for ENT surgeons

Clinical Otolaryngology, Volume 43, Issue 3, Page 791-794, June 2018.


https://ift.tt/2rLYeHI

Issue Information

Clinical Otolaryngology, Volume 43, Issue 3, Page i-iv, June 2018.


https://ift.tt/2GtlCxU

Author Guidelines

Clinical Otolaryngology, Volume 43, Issue 3, Page 997-998, June 2018.


https://ift.tt/2rO9OSq

Does Hypoxia‐Inducible Factor ‐1 α (HIF‐1α) C1772T polymorphism predict short‐term prognosis in patients with oral squamous cell carcinoma (OSCC)?

Journal of Oral Pathology &Medicine, EarlyView.


https://ift.tt/2ILRof0

The expression of programed death ligand‐1 could be related with unfavorable prognosis in salivary duct carcinoma

Journal of Oral Pathology &Medicine, EarlyView.


https://ift.tt/2IqpYYr

Successful treatment of cutaneous metastatic melanoma with high‐dose intralesional interleukin‐2 treatment combined with cryosurgery

Dermatologic Therapy, EarlyView.


https://ift.tt/2rRp6F4

Radial forearm flaps with venous compromise: correlations between salvage techniques and their rates of success

elsevier-non-solus.png

Publication date: Available online 8 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): Z. Qin-kai, G. Bing, D. Wei, T. Xue-xin, S. Jian, Z. Chen-ping, X.-j. Qin
We retrospectively analysed the reliability of anastomosis of the deep venous system as a salvage technique for a free radial forearm flap that has developed venous compromise. The primary predictors were the salvage techniques, which comprised anastomosis of the deep venous system and a repeat of the original anastomosis, and the primary outcome measure was the rate of success. The potential confounders included original venous outflow, the original causes of the venous compromise, and the number of venous anastomoses. The chi squared test, Fisher's exact test, and the Cochran–Mantel–Haenszel test were used for statistical analysis as appropriate. The final sample comprised 42 patients who required re-exploration for venous compromise. The salvage rates were 15/18 when anastomosis of the deep venous system was chosen as a salvage technique and 9/24 and when the original anastomosis was done again (p=0.003, OR 2.222, 95% CI 1.274 to 3.876). The salvage rate of venous compromise was higher in patients who had anastomoses of the deep venous system than in those in whom the original anastomosis was repeated.



https://ift.tt/2rPY1SX

Current thinking in medical education research: an overview

elsevier-non-solus.png

Publication date: Available online 30 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): R. Elledge
Medical education is fast becoming a separate focus, and together with their clinical commitments, many clinicians now seek higher qualifications and professional accreditation in the field. Research is also developing, and there is a need for evidence-based practice in education, just as in clinical work. This review gives an overview of research into medical education, and explains the fundamentals of educational theory and the specific considerations for the quantitative and qualitative research methods that pertain to it. It also explains the application of these methods to two growing areas of research: technology-enhanced learning (TEL) and normative ethics in training.



https://ift.tt/2rPAL8g

New method of alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication-related osteonecrosis of the jaw

elsevier-non-solus.png

Publication date: Available online 8 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): C. Bräuer, G. Lauer, H. Leonhardt




https://ift.tt/2GrvwjM

Factors predicting success in the Intercollegiate Membership of the Royal College of Surgeons (MRCS) examination: a summary for OMFS

elsevier-non-solus.png

Publication date: Available online 5 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): D.S.G. Scrimgeour, J. Cleland, A.J. Lee, P.A. Brennan
The Intercollegiate Membership of the Royal College of Surgeons (MRCS, parts A and B) is a mandatory examination for entry into higher surgical training in the UK. We investigated which factors predict success in both the written (Part A) and clinical (Part B) parts of the examination, and provide a summary for oral and maxillofacial surgeons (OMFS). All UK graduates who attempted both parts between 2007 and 2016 were included. There was a positive correlation between the scores in parts A and B (r=0.41, p<0.01). For Part A, men (odds ratio (OR) 2.78; 95% CI 1.83 to 4.19), white candidates (OR 1.70; 95% CI 1.52 to 1.89), and younger graduates (under 29years of age), were more likely to pass (OR 2.60; 95% CI 1.81 to 3.63). Foundation year one (FY1) doctors had higher pass rates than all other grades (e.g. core surgical trainee 2 vs. FY1 OR 0.50; 95% CI 0.32 to 0.77). The number of attempts at Part A and the final score, as well as ethnicity and stage of training, were independent predictors of success in Part B. Candidates who did well in Part A were more likely to do well in Part B. Several independent predictors of success were identified, but only the stage of training and ethnicity were common predictors in both parts. Higher scores obtained by younger candidates might be relevant to OMFS trainees who take Part A after studying medicine as a second degree.



https://ift.tt/2rOkjW5

Re: Gillies temporal incision: an alternative approach to biopsy of the superficial temporal artery

elsevier-non-solus.png

Publication date: Available online 30 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): M. Shastri, K. Chouglay, C. Newlands




https://ift.tt/2rPXNLB

Cystadenoma of the mandible: a rare presentation

elsevier-non-solus.png

Publication date: Available online 5 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): H. Mahmood, C. Murphy, V. Oktselglou
To our knowledge this is only the second reported case of a cystadenoma that arose in the mandible. These are rare benign epithelial neoplasms of the salivary gland that comprise 0.8%-6.3% of all minor tumours of the salivary gland. Because cystadenoma of the mandible is so rare, there is little evidence or guidance about management, and enucleation remains the recommended treatment. Careful histological diagnosis is important for differentiation from other morphologically similar salivary gland tumours such as a mucoepidermoid carcinoma.



https://ift.tt/2rMWOwe

Retrospective study of eligibility for orthognathic surgery using the Index of Orthognathic Functional Treatment Need (IOFTN)

elsevier-non-solus.png

Publication date: Available online 17 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): P. Fowler, T. King, M. Lee, J. Erasmus
To assess the functional needs of orthognathic patients who had been accepted for treatment by Christchurch Hospital, New Zealand, we made a retrospective assessment of 80 consecutive patients using the Index of Orthognathic Functional Treatment Need (IOFTN). Eligibility was based on the Severity and Outcome Index (SOI) score of ≤3 derived from seven lateral cephalometric measurements (three skeletal, three dental, and one soft tissue), which made allowances for asymmetrical or reported important functional issues. The IOFTN grades 4 or 5 indicated "great" or "very great" need for treatment, and we also used a self-reported oral health-related quality of life (QoL) questionnaire (OHIP-14). Sixty-eight patients were considered eligible using the SOI, and 71 when the IOFTN was used. Eight who were eligible using the SOI would not have been eligible using the IOFTN while 11 who were not considered eligible using the SOI scored ≥4 using the IOFTN. However, when it was compared with the SOI, the IOFTN tended to underscore those patients who were Class III/skeletal 3 with reverse overjets of <3mm and with no reported functional difficulties, while it tended to overscore Class II/skeletal 2 patients with overjets ≥6mm. We found no association found between the OHIP-14 and the SOI or the IOFTN. Further investigations are required to clarify functional difficulties that are applicable to the IOFTN grading, and to find out the most appropriate self-reported, oral-health-related QoL measure(s) to complement the use of the IOFTN.



https://ift.tt/2GrQGOG

Re: Is a fractured mandible an emergency?

elsevier-non-solus.png

Publication date: Available online 4 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): D. Hammond, R. Welbury




https://ift.tt/2Ioeb0W

Retrospective analysis of postoperative interventions in mandibular fractures: a shift towards outpatient day surgery care

elsevier-non-solus.png

Publication date: Available online 10 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): Shiva Subramaniam, Anthony Febbo, James Clohessy, Alexander Bobinskas
The management of fractured mandibles typically involves admission and operation at the time of presentation. While this should involve only a short stay in hospital these patients are surgically stable, and so priority is often given to more urgent cases. We retrospectively evaluated the postoperative medical requirements of patients who were operated on at Fiona Stanley Hospital, Perth, Western Australia between 1 January 2015 and 31 December 2016. Patients were excluded if they had had multiple facial fractures, multiple injuries, had fractures that were comminuted or in edentulous mandibles, and those who had been in hospital for preoperative medical investigations and care. We also excluded fractures in children aged 16 years and under. The results showed that of a total of 173 patients, 12 had had medical consultations during their hospital stay, and only four had required intervention. The mean (range) preoperative time was 37 (1 - 46) hours and that from operation to discharge 21.5 (2 - 93) hours. While traditional management involves emergency admission and open reduction and internal fixation as soon as possible, delays of up to five days were not associated with appreciably worse outcomes. This, together with the negligible requirements for medical management perioperatively, provides a strong argument for a selected group to be treated as outpatients.



https://ift.tt/2GqkPxC

Maxillofacial injuries in patients with major trauma

elsevier-non-solus.png

Publication date: Available online 4 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): D.M. McGoldrick, M. Fragoso-Iñiguez, T. Lawrence, K. McMillan
Major trauma is an important cause of mortality and morbidity worldwide. Mortality is high with rates over 10% commonly reported. We studied the epidemiology and aetiology of maxillofacial injuries in patients who presented with major trauma as recorded nationally by retrospectively analysing the database of the Trauma Audit Research Network from 2001 to 2015. All patients who had major trauma with associated maxillofacial injuries were included in the analysis. Of 104645 patients recorded as having had major trauma during the study period, 22148 (21.2%) had an associated maxillofacial injury. Most of them were male (74.2%), and the type of injury was usually blunt (97.5%). Road traffic collisions were the most common mechanism (44.1%), followed by falls of less than 2m (21.6%). An associated serious head injury was more common in those who had a facial injury (81% compared with 60.6%, p<0.0001). Nearly all the facial injuries (94%) were minor, or moderately severe. Maxillofacial injuries commonly present with major trauma but are rarely severe. A maxillofacial injury may indicate an increased likelihood of an associated head injury.



https://ift.tt/2IpMzIP

Severe trismus and contraindicated exodontia in a patient with fibrodysplasia ossificans progressiva: case report

elsevier-non-solus.png

Publication date: Available online 3 May 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): A. Geddis-Regan
Fibrodysplasia ossificans progressiva is a rare genetic disease of connective tissue in which muscles, ligaments, and tendons ossify either spontaneously or after trauma. Patients can develop physical disabilities and restriction of respiratory function. A patient attended a maxillofacial surgery outpatient clinic with severe trismus and mouth opening limited to 2mm. The risks of intervention were many from both anaesthetic and surgical perspectives, which prevented the extraction of carious teeth. The patient was referred to a special care dentistry team who provided endodontic stabilisation without local anaesthesia. In the case of severe infection, surgical intervention would be challenging to justify.



https://ift.tt/2rVdzVF

Editorial Board

elsevier-non-solus.png

Publication date: May 2018
Source:British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 4





https://ift.tt/2rPAJxa

New technique for endoscopically-assisted particulate graft reconstruction of the mandible

elsevier-non-solus.png

Publication date: Available online 30 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): C. Ferretti, J. Reyneke, M. Heliotis, U. Ripamonti
The reconstruction of mandibular defects using particulate grafts is a proven technique that restores the osseous anatomy effectively. Secondary osseous reconstruction can be accomplished with endoscopic assistance and reduced-access incisions if an intermediate spacer is placed during resection. Two patients required reconstruction after resection of mandibular ameloblastomas. We used a modified protocol that involved the implantation of a graft of particulate corticocancellous bone after removal of the spacer, and prepared the recipient site under endoscopic guidance with small extraoral incisions. The grafts healed uneventfully and matured into ossicles suitable for the placement of osseointegrated implants.



https://ift.tt/2Grvk42

Numbness of the lower lip does not adversely affect quality of life or patients’ satisfaction after mandibular orthognathic surgery

elsevier-non-solus.png

Publication date: Available online 27 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): Z. Ahmad, J. Breeze, R. Williams
Measures of patient-reported quality of life (QoL) are increasingly being used to tailor services that are funded by Clinical Commissioning Groups (CCG) in England. Mandibular osteotomies may result in altered sensation of the lower lip, but we know of limited evidence about the resulting effect on QoL. The modified Bristol orthognathic patient outcomes questionnaire was given to patients who had mandibular osteotomies at the Queen Elizabeth Hospital, Birmingham, between March 2006 and April 2016. Questionnaires were collected at the final orthognathic postoperative appointment. The significance of the difference in QoL between those who had altered sensation of the lower lip and those who did not was compared using a two-tailed t test. During this period 170 patients had mandibular orthognathic operations. Completed questionnaires were received from 117 of those patients (69%) during this period, after a follow up of about six months. We found no significant difference between the perceived benefits of treatment between the 41 who had altered sensation and the 74 who did not (p=0.30). Only 5/41 who reported residual numbness six months postoperatively stated that they would not choose to have the same treatment again. In conclusion, orthognathic surgery results in an appreciable improvement in QoL and should continue to be funded by CCG in England. Contrary to the perception of some clinicians, those patients with residual numbness of the lip did not have significantly poorer QoL. Future interpretation of the data will be improved if they are collected both before and after the operation.



https://ift.tt/2rN4QFp

Training Groups

elsevier-non-solus.png

Publication date: May 2018
Source:British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 4





https://ift.tt/2rQX0tT

“Flipped classrooms” in training in maxillofacial surgery: preparation before the traditional didactic lecture?

elsevier-non-solus.png

Publication date: Available online 30 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): Ross Elledge, Samantha Houlton, Stephanie Hackett, Martin J. Evans
While virtual learning environments (VLE) can be used in medical education as stand-alone educational interventions, they can also be used in preparation for traditional "face-to-face" training sessions as part of a "flipped classroom" model. We sought to evaluate the introduction of this model in a single module on maxillofacial radiology from a course on trauma skills. Course delegates were randomised into two groups: one was given access to an e-learning resource (test group) and the other attended a traditional didactic lecture (control group). Knowledge and confidence were assessed before and after the course with a 20-question single-best-answer paper and a 10-situation 100mm visual analogue scale (VAS) paper, respectively. All participants were then given free access to the VLE for 30days and were invited to take part in an e-survey. Neither group showed improvements in the single-best-answer scores, but both groups showed comparable improvements in VAS (control: median (range) values improved from 40.8 (17.7–82.5) mm to 62.8 (35.3–88.7) mm, p=0.001; test group: from 47.7 (10.9–58.1) mm to 60.5 (32.4–75.6) mm, p=0.005). Half of the respondents stated that they preferred the "flipped classroom" approach, and 22/22 stated that they would be "likely" or "very likely" to use an e-learning resource with expanded content. The "flipped classroom" approach was well received and there were comparable improvements in confidence. As maxillofacial radiology lends itself to online instruction with its reliance on the recognition of patterns, and problem-based approach to learning, a piloted e-learning resource could be developed in this area.



https://ift.tt/2rMUEgq

Re: Gillies temporal incision: an alternative approach to biopsy of the superficial temporal artery

elsevier-non-solus.png

Publication date: Available online 30 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): G. Markose, R.M. Graham




https://ift.tt/2rPX2SL

Re: Retroseptal transconjunctival approach for fractures of the zygomaticomaxillary complex: a retrospective study

elsevier-non-solus.png

Publication date: Available online 27 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): A. Sayan, V. Ilankovan




https://ift.tt/2rOkcd7

Feasibility of a new V-shaped incision for parotidectomy: a preliminary report

elsevier-non-solus.png

Publication date: Available online 17 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): D. Ahn, J.H. Sohn, G.J. Lee
We report the design of a new V-shaped incision for parotidectomy that involves only preauricular and postauricular incisions and no hairline or upper cervical incision. It can be used to approach almost all the superficial parotid region, including the superior and anterior divisions, with minimal scarring. To evaluate its technical feasibility, safety, and cosmetic results, we prospectively enrolled 15 patients (between September 2015 and September 2016) who had partial parotidectomy as the primary treatment for benign parotid tumours. Operations were successfully completed through this approach alone in 14 (mean (range) operating time: 120 (105–142) minutes; drainage volume: 51 (23–70) ml; and duration of drainage: 2.6 (2–4) days). There were no serious complications such as paralysis of the facial nerve or necrosis of the wound. The mean (range) visual analogue scale (VAS) and Vancouver Scar Scale scores for the scars were 9 (8–10) and 0.9 (0–3), respectively. A V-shaped incision for partial parotidectomy is technically feasible and safe, and can produce good cosmetic results in selected patients with benign parotid tumours. Our results need to be confirmed in larger studies and case-control trials.



https://ift.tt/2GnTtZf

Incidence and treatment of complications in patients who had third molars or other teeth extracted

elsevier-non-solus.png

Publication date: Available online 16 April 2018
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): I. Miclotte, J.O. Agbaje, Y. Spaey, P. Legrand, C. Politis
The aim of this study was to compare the incidence of complications after extraction of third molars (M3) or other teeth, and to describe their management. We made a retrospective cohort study of patients having M3 or other teeth extracted, and recorded complications up to two years' follow-up. A total of 142 complications developed after 2355 procedures (6%) – 7% after extraction of M3 compared with 5% after extractions of other teeth (p=0.024). The three most common complications were wound infection (2%), pain without apparent cause (<1%), and oroantral communication (<1%). Patients who had M3 extracted were at increased risk of complications compared with those who had other teeth extracted (Odds ratio (OR) 1.5, p=0.024), particularly for infection (OR 5.9, p<0.001) and hypoaesthesia (OR 8.4, p=0.027). Half of all patients with a complication were treated with antibiotics orally. The incidence of postoperative bleeding was 0.6% as a result of suboptimal management of antithrombotic drugs in extractions of teeth other than M3. Finally, optimal treatment of the complications was compared with the available evidence. Prevention and treatment of these complications could reduce the incidence, particularly of bleeding.



https://ift.tt/2rMWFJc

Heterogeneity in skin manifestations of spotted fever group rickettsial infection in Australia

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2KvBLp2

Dermatoscopic chaos of border‐abruptness led to diagnosis of a minute melanoma

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2k4d4op

A case of acitretin‐induced haemorrhagic lesions in Darier disease

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2Kt07Q8

Trichoscopy helps to predict the time point of clinical cure of tinea capitis

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2k4cCGJ

Nanoemulsions and dermatological diseases: contributions and therapeutic advances

International Journal of Dermatology, EarlyView.


https://ift.tt/2GrsjRg

Leukocytoclastic vasculitis associated with immunoglobulin A lambda monoclonal gammopathy of undetermined significance: A case report and review of previously reported cases

The Journal of Dermatology, EarlyView.


https://ift.tt/2rNRUzp

Case of anti‐p200 pemphigoid accompanying uterine malignancy

The Journal of Dermatology, EarlyView.


https://ift.tt/2GpWJ6k

Case of S100‐positive benign cephalic histiocytosis involving monocyte/macrophage lineage marker expression

The Journal of Dermatology, EarlyView.


https://ift.tt/2rMNGYE

Brodalumab‐induced palmar pustular eruption and joint swelling accompanied by muscle pains in two cases of psoriasis

The Journal of Dermatology, EarlyView.


https://ift.tt/2GpWwjy

Issue Information

Head &Neck, Volume 40, Issue 6, Page 1103-1105, June 2018.


https://ift.tt/2k3bUJV

Extracellular interleukin‐17F has a protective effect in oral tongue squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2rP74DI

Are European dermatology patients treated unequally?

British Journal of Dermatology, Volume 178, Issue 5, Page 991-991, May 2018.


https://ift.tt/2wJPiY2

Allocation of biologics: health economics and clinical decision making in plaque psoriasis

British Journal of Dermatology, Volume 178, Issue 5, Page 997-998, May 2018.


https://ift.tt/2IQp8rG

After the approval of dupilumab for moderate‐to‐severe atopic dermatitis: what is next on the research agenda?

British Journal of Dermatology, Volume 178, Issue 5, Page 992-993, May 2018.


https://ift.tt/2wOiVYg

Beyond skin deep: taking bedside dermatology to the next level with noninvasive technologies

British Journal of Dermatology, Volume 178, Issue 5, Page 994-996, May 2018.


https://ift.tt/2ImZjQd

News and Notices

British Journal of Dermatology, Volume 178, Issue 5, Page 1226-1227, May 2018.


https://ift.tt/2GnJxyV

U.K. Psychodermatology Society Annual Meeting, Royal College of Physicians, London, 26 January 2017

British Journal of Dermatology, Volume 178, Issue 5, Page e342-e346, May 2018.


https://ift.tt/2IQoTgg

U.K. Psychodermatology Society Annual Meeting, St Thomas’ Hospital, London, 25 January 2018

British Journal of Dermatology, Volume 178, Issue 5, Page e347-e353, May 2018.


https://ift.tt/2GpaXEp

Issue Information

British Journal of Dermatology, Volume 178, Issue 5, Page i-v, May 2018.


https://ift.tt/2IsnA7B

Analysis of anti‐tumour necrosis factor‐induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics

British Journal of Dermatology, Volume 178, Issue 5, Page e364-e364, May 2018.


https://ift.tt/2wNQaem

Changes in filaggrin degradation products and corneocyte surface texture by season

British Journal of Dermatology, Volume 178, Issue 5, Page e365-e365, May 2018.


https://ift.tt/2IoGnAV

Image Gallery: the new age of dermoscopy: optical super‐high magnification

British Journal of Dermatology, Volume 178, Issue 5, Page e330-e330, May 2018.


https://ift.tt/2wNPWnw

Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case–control study

British Journal of Dermatology, Volume 178, Issue 5, Page e372-e372, May 2018.


https://ift.tt/2IMM0Io

Cellulitis: what to measure, how to define? Systematic review of outcomes from cellulitis trials

British Journal of Dermatology, Volume 178, Issue 5, Page 1000-1001, May 2018.


https://ift.tt/2wNPC8i

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria

British Journal of Dermatology, Volume 178, Issue 5, Page e362-e362, May 2018.


https://ift.tt/2IST5ae

Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial

British Journal of Dermatology, Volume 178, Issue 5, Page e361-e361, May 2018.


https://ift.tt/2GoZrsQ

Inflammatory skin eruptions induced by anti‐tumour necrosis factor‐α therapy differ undeniably from psoriasis or eczema

British Journal of Dermatology, Volume 178, Issue 5, Page 1007-1008, May 2018.


https://ift.tt/2ImVASZ

Pembrolizumab treatment of a patient with xeroderma pigmentosum with disseminated melanoma and multiple nonmelanoma skin cancers

British Journal of Dermatology, Volume 178, Issue 5, Page 1009-1009, May 2018.


https://ift.tt/2GpQL5D

Adjunctive therapy for healing venous leg ulcers

British Journal of Dermatology, Volume 178, Issue 5, Page 1005-1006, May 2018.


https://ift.tt/2Iq9Fii

Image Gallery: Cutaneous findings in Hunter syndrome

British Journal of Dermatology, Volume 178, Issue 5, Page e329-e329, May 2018.


https://ift.tt/2GrhQ8q

Moving core outcome sets in dermatology forward

British Journal of Dermatology, Volume 178, Issue 5, Page 1010-1010, May 2018.


https://ift.tt/2ImVyKR

Toll‐like receptor signalling induces the expression of serum amyloid A in epidermal keratinocytes and dermal fibroblasts

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Gs1MDg

Yellowish papules on the glans

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rOQNiN

Paraneoplastic pemphigus foliaceus related to underlying breast cancer

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2GrHyJT

Improvement in facial discoid dermatosis with calcipotriol/betamethasone ointment and low‐dose acitretin

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IoLv8b

Persistent unilateral ulcer of the ear as the first manifestation of relapsing polychondritis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rQqUOG

Presence of human papillomavirus 16 in acral Bowen disease as a predictor of a less efficacious response to photodynamic therapy: a retrospective case series of nine patients

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rLnFJq

Dermatology on‐call should be commissioned and funded to support acute hospital services

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Gujmqs

Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1–2 and ARVCF, causing renal damage

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rTFkyH

Lichenoid paraneoplastic pemphigus associated with follicular lymphoma without detectable autoantibodies

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2GrJ0Mm

An enlarging pedunculated nodule on the shoulder of a 21‐year‐old man

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IoKgG0

Dermatological aspects of tularaemia: a study of 168 cases

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rP08pX

Erythema nodosum arising during everolimus therapy for tuberous sclerosis complex

Pediatric Dermatology, EarlyView.


https://ift.tt/2KxCcPw

Dermal non‐neural granular cell tumor in a 3‐year‐old child

Pediatric Dermatology, EarlyView.


https://ift.tt/2k6Yb4S

Hand, foot, and mouth disease photolocalized to sunburn

Pediatric Dermatology, EarlyView.


https://ift.tt/2KsTwFx

Therapeutic interventions to lessen the psychosocial effect of vitiligo in children: A review

Pediatric Dermatology, EarlyView.


https://ift.tt/2k27XoW

Multiple superficial oral mucoceles after Mycoplasma‐induced mucositis

Pediatric Dermatology, EarlyView.


https://ift.tt/2Kz3jKr

Lower lip capillary malformation associated with lymphatic malformation without overgrowth: Part of the spectrum of CLAPO syndrome

Pediatric Dermatology, EarlyView.


https://ift.tt/2k319Hy

Cutaneous fibrolipomatous hamartoma: Report of 2 cases with retrocalcaneal location

Pediatric Dermatology, EarlyView.


https://ift.tt/2KxD9aQ

Hand‐foot‐skin reaction related to use of the multikinase inhibitor sorafenib and hard orthotics

Pediatric Dermatology, EarlyView.


https://ift.tt/2InyPhy

Risk factors for ocular complications in periocular infantile hemangiomas

Pediatric Dermatology, EarlyView.


https://ift.tt/2rPkDml

Erythema multiforme after orf virus infection

Pediatric Dermatology, EarlyView.


https://ift.tt/2rNHyPQ

Surgical treatment strategy in Warthin tumor of the parotid gland

Publication date: Available online 16 May 2018
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul Lim
IntroductionWarthin tumors are the second most common benign tumors of the parotid gland. We examined the clinical features of Warthin tumors in our hospital, and analyzed the consistency within the literatures.ObjectiveThe aim of this study is to analyze the clinical features of Warthin tumors in our 10-year experience of 118 Warthin tumors undergoing surgery at a single institute.MethodsFrom December 2006 to December 2016, 110 patients who underwent surgical treatment for Warthin tumors were identified based on their medical records.ResultsA total of 118 parotid gland operations were performed in 110 patients. Almost 90% of Warthin tumors were found in males, and average patient age was 66.1±6.1 years. The prevalence of smoking history was 89.1% (98/110). Eight patients (7.3%) had bilateral Warthin tumors. Seventy-seven lesions (65.3%) were located in the parotid tail portion, followed by 34 lesions in the superficial lobe (28.8%) and 7 lesions in the deep lobe (5.9%).ConclusionWe determined the appropriate extent of surgery depending on the fine needle aspiration cytology and tumor location by computed tomography scans. Partial facial dysfunction after the operation was detected in 12 cases, and facial nerve function recovered within 3 months. Only one patient experienced a recurrence, and was disease free after the re-operation. We suggest that our treatment algorithm, depending on the location of tumors and the result of fine needle aspiration cytology, can be useful to determine the appropriate extent of surgery for Warthin tumors.



https://ift.tt/2GqzicY

Gender differences in binaural speech-evoked auditory brainstem response: are they clinically significant?

grey_pxl.gif

Publication date: Available online 17 May 2018
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Bahram Jalaei, Mohd Hafiz Afifi Mohd Azmi, Mohd Normani Zakaria
IntroductionBinaurally evoked auditory evoked potentials have good diagnostic values when testing subjects with central auditory deficits. The literature on speech-evoked auditory brainstem response evoked by binaural stimulation is in fact limited. Gender disparities in speech-evoked auditory brainstem response results have been consistently noted but the magnitude of gender difference has not been reported.ObjectiveThe present study aimed to compare the magnitude of gender difference in speech-evoked auditory brainstem response results between monaural and binaural stimulations.MethodsA total of 34 healthy Asian adults aged 19–30 years participated in this comparative study. Eighteen of them were females (mean age=23.6±2.3 years) and the remaining sixteen were males (mean age=22.0±2.3 years). For each subject, speech-evoked auditory brainstem response was recorded with the synthesized syllable /da/ presented monaurally and binaurally.ResultsWhile latencies were not affected (p>0.05), the binaural stimulation produced statistically higher speech-evoked auditory brainstem response amplitudes than the monaural stimulation (p<0.05). As revealed by large effect sizes (d>0.80), substantive gender differences were noted in most of speech-evoked auditory brainstem response peaks for both stimulation modes.ConclusionThe magnitude of gender difference between the two stimulation modes revealed some distinct patterns. Based on these clinically significant results, gender-specific normative data are highly recommended when using speech-evoked auditory brainstem response for clinical and future applications. The preliminary normative data provided in the present study can serve as the reference for future studies on this exam among Asian adults.



https://ift.tt/2INprmY

The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases

Publication date: Available online 16 May 2018
Source:Allergology International
Author(s): Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need.The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies. It is a once-daily tablet treatment to be self-administered after the first dose has been provided under the supervision of a physician with experience in the diagnosis and treatment of allergic diseases. Once the first dose is adequately tolerated, subsequent doses may be self-administered. SLIT-tablets have proven efficacy for allergic rhinitis (AR) with and without conjunctivitis (C) and allergic asthma (AA) in adults, children, and poly-sensitized allergic patients. Meta-analyses indicate that SLIT-tablets have superior or similar efficacy compared with anti-allergic pharmacotherapies for seasonal AR and superior efficacy for perennial AR. SLIT-tablets have also demonstrated clinically relevant improvements of asthma, with significant reductions in the following: daily inhaled corticosteroid use, risk of asthma exacerbations, and asthma symptoms. SLIT-tablets are generally well tolerated, with a low risk of systemic allergic reactions. The most common treatment-related adverse events are mild-moderate oral reactions. Current evidence supports SLIT-tablets to be considered as an alternative or add-on treatment to pharmacotherapy for AR/C and asthma. Future SLIT developments may include early intervention to prevent the development or progression of allergic disease in children.



https://ift.tt/2wKFu08

Case 15-2018: An 83-Year-Old Woman with Nausea, Vomiting, and Confusion

Presentation of Case. Dr. Andrew S. Hoekzema (Medicine): An 83-year-old woman was admitted to this hospital in the winter because of nausea, vomiting, diarrhea, and confusion. One week before admission, rhinorrhea, sore throat, and nonproductive cough developed. The patient felt feverish but did…

https://ift.tt/2Ky3lCf

Malignes Melanom − Früherkennung, Diagnostik und Nachsorge

Zusammenfassung

Hintergrund

Das maligne Melanom ist eine häufige Hautkrebsart mit einer sehr hohen Mortalität. In Europa versterben jährlich etwa 22.000 Menschen daran, davon etwa 2700 Patienten alleine in Deutschland. Die Inzidenz zeigt seit Jahren eine steigende Tendenz. Bedeutende Risikofaktoren für die Entstehung eines malignen Melanoms sind die Anzahl der melanozytären Nävi am Körper, eine positive Familienanamnese für Melanom und genetische Prädisposition.

Ziel

In dieser Arbeit soll auch dem Nichtdermatoonkologen eine Übersicht über die Diagnostik, Behandlung, Stadieneinteilung und Nachsorge des malignen Melanoms vermittelt werden.

Material und Methoden

Es wurde eine selektive Literaturrecherche in Medline über Pubmed erstellt und mit eigenen Erfahrungen der Autoren ergänzt.

Ergebnisse

Es werden 4 klinische Formen des Melanoms unterschieden: superfiziell spreitende Melanome (SSM), Lentigo-maligna-Melanome (LMM), akral-lentiginöse Melanome (ALM) und noduläre Melanome (NM). Diese unterscheiden sich sowohl in ihrem klinischen Erscheinungsbild, ihrer Lokalisation und Entwicklung und letztlich auch ihrer Prognose, die für das ALM und NM am ungünstigsten ist. Zur Diagnosesicherung und zur klinischen und pathologischen Stadieneinteilung ist eine operative Erstversorgung von kutanen Melanomen unerlässlich. Ab einer Tumordicke nach Breslow über 1 mm wird die diagnostische Exzision des Wächterlymphknotens (WLK) empfohlen. Bei Befall des WLK sollte zunächst eine Ausbreitungsdiagnostik mittels Schnittbildgebung erfolgen. Ist eine Exzision und Nachexzision und ggf. die WLK-Biopsie erfolgt, wird eine stadiengerechte Ausbreitungsdiagnostik empfohlen. Die empfohlene Nachsorge des malignen Melanoms gestaltet sich stadienadaptiert und entsprechend der aktuellen Leitlinie.



https://ift.tt/2wMvxiu

Comparative Post-operative Pain Analysis Between Coblator Assisted and Bipolar Diathermy Tonsillectomy in Paediatric Patients

Abstract

Tonsillectomy is one of the commonly performed otolaryngological operations. Despite a range of different techniques post-operative pain remains a major side-effect of this operation. Coblation assisted tonsillectomy is a latest technique of tonsillectomy. This technique is said to be associated with less intra-operative bleeding and less postoperative morbidity. We conducted a study in 100 patients to compare the pain scores between coblation assisted and bipolar diathermy tonsillectomy by FLACC score and Wong Baker scale score. The data so collected was statistically analysed using a t test and p values were calculated. The p value was highly significant (p < 0.001) for both scores in coblation assisted tonsillectomy 6 h postoperatively and on 1st postoperative day (p < 0.05). On 7th post-operative day however there was no significant difference in post-operative pain score using FLACC score in both groups but Wong baker scale scores were still significant. We concluded that post-operative pain was less with coblator assisted tonsillectomy as compared to bipolar diathermy tonsillectomy at least in early post-operative period.



https://ift.tt/2IvP9cp

Comparative Post-operative Pain Analysis Between Coblator Assisted and Bipolar Diathermy Tonsillectomy in Paediatric Patients

Abstract

Tonsillectomy is one of the commonly performed otolaryngological operations. Despite a range of different techniques post-operative pain remains a major side-effect of this operation. Coblation assisted tonsillectomy is a latest technique of tonsillectomy. This technique is said to be associated with less intra-operative bleeding and less postoperative morbidity. We conducted a study in 100 patients to compare the pain scores between coblation assisted and bipolar diathermy tonsillectomy by FLACC score and Wong Baker scale score. The data so collected was statistically analysed using a t test and p values were calculated. The p value was highly significant (p < 0.001) for both scores in coblation assisted tonsillectomy 6 h postoperatively and on 1st postoperative day (p < 0.05). On 7th post-operative day however there was no significant difference in post-operative pain score using FLACC score in both groups but Wong baker scale scores were still significant. We concluded that post-operative pain was less with coblator assisted tonsillectomy as compared to bipolar diathermy tonsillectomy at least in early post-operative period.



https://ift.tt/2IvP9cp