EGFR silencing of tumour-suppressing genes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
A Yale-led study describes how a known cancer gene, EGFR, silences genes that typically suppress tumours. The finding, published in Cell Reports, may lead to the development of more effective, individualised treatment for patients with lung cancer and… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyTQK via IFTTT
Potent anti-tumour antibiotic uncialamycin synthesis streamlined
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Scientists have improved the production of a potent anti-tumour antibiotic known as uncialamycin. The Rice lab of synthetic chemist K.C. Nicolaou announced this month it had streamlined the total synthesis of uncialamycin to make it simpler to create… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhqKp via IFTTT
Broccoli sprout extract may protect against oral cancer recurrence
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Potent doses of broccoli sprout extract activate a «detoxification» gene and may help prevent cancer recurrence in survivors of head and neck cancer, according to a trial by the University of Pittsburgh Cancer Institute, partner with UPMC Cancer Center,… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyVrt via IFTTT
Mycobacterium in olive oil for bladder cancer treatment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Researchers at the Universitat Autònoma de Barcelona (UAB) with the collaboration of the Institute for Bioengineering of Catalonia (IBEC), led by the professor of the UAB Department of Genetics and Microbiology Esther Julián, announced one year ago that… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhtWp via IFTTT
Mechanism of DNMT3A-driven leukaemia uncovered
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Scientists have previously identified a series of genetic errors that commonly occur inside cancerous blood cells, but it hasn’t been clear exactly how those genetic malfunctions create immature blood cells that overpopulate, crowd out healthy cells and… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyUE6 via IFTTT
New cancer immunotherapy drugs linked to arthritis in some patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Case reports on 13 cancer patients suggest that a small number of cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at some higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhzgB via IFTTT
Pharmacologic Neuroprotection for Functional Outcomes After Traumatic Brain Injury: A Systematic Review of the Clinical Literature
Abstract Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide. The deleterious effects of secondary brain injury may be attenuated by early pharmacological therapy in the emergency room and intensive care unit (ICU). Current medical management of acute TBI is primarily supportive, aimed at reducing intracranial pressure (ICP) and optimizing cerebral perfusion. There are no pharmacological therapies to date that have been unequivocally demonstrated to improve neurological outcomes after TBI. Objectives The purpose of this systematic review w... περισσότερα »
Understanding the pain of photodynamic therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Severe paleness and photosensitivity are two symptoms of a rare group of hereditary diseases that affect haem, a substance in the blood. While these metabolic disorders – known as the porphyrias – are extremely rare, a similar effect is often… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyT2P via IFTTT
Novel gene-hunting method implicates new culprit in pancreatic cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Using an innovative approach to identify a cancer’s genetic vulnerabilities by more swiftly analysing human tumours transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhucX via IFTTT
Health-care providers do not fully understand cancer risk from CT scans
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Computed tomography (CT) scans are an invaluable diagnostic tool in modern medicine, but they do come at a price: exposing patients to potentially dangerous ionising radiation. Doctors and other healthcare professionals may not be fully aware of a CT… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyQUX via IFTTT
Nanotechnology and math ‘deliver two-in-one punch’ for cancer therapy resistance
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Math, biology and nanotechnology are becoming strange, yet effective bed-fellows in the fight against cancer treatment resistance. Researchers at the University of Waterloo and Harvard Medical School have engineered a revolutionary new approach to cancer… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhklS via IFTTT
Discovery of an epigenetic regulator of tumourigenesis suggests new strategies against
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Scientists have identified a previously unknown mechanism by which a protein called CBX8 promotes tumour growth in the most lethal forms of breast cancer. The study, published today in the journal Cell Reports, underscores the need for cancer researchers… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RyUEj via IFTTT
Free-living ruddy ground dove ( Columbina talpacoti ): a report on leukocyte and weight values
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Abstract The Columbina talpacoti species, a common type of bird in Brazil, is often the target of illegal trade or used as pets, which can lead to the threat of extinction as the number of individuals of the species decreases. As this is a rare species with unknown hematological parameters, this study aimed to describe […]
Amylolytic glycoside hydrolases
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RmmBh via IFTTT
Prof Michael Seckl: Why attend Future Horizons in Lung Cancer?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Prof Michael Seckl (Imperial College London, London, UK) introduces the upcoming meeting ‘Future Horizons in Lung Cancer’ coming to the Royal Society of Medicine in London on 1-2 September 2016. But why should healthcare professionals be interested in… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28RySfx via IFTTT
Specific mutations in leukaemia patients’ blood predicts survival
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Dr Metzeler talks to ecancertv at EHA 2016 about the presence of specific mutations in blood and bone marrow cells in leukaemia patients which predict survival. He finds an increased risk of relapse among patients who harbour a persistent population… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XhqKh via IFTTT
Feedback: Noel Edmonds zapped over electropad cancer claims
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Plus aliens appear over tax office, the half-life of teaspoons, 131 flavours of frog, dining out of nappies, ancient bog butter, and more from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XdkBG via IFTTT
The Practicability of Transnasal Esophagoscopy and the Evaluation of Patient's Perception: A Prospective Study.
*The Practicability of Transnasal Esophagoscopy and the Evaluation of Patient's Perception: A Prospective Study.* Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Polat B, Karahatay S, Birkent H, Gerek M Abstract Objectives: Transnasal esophagoscopy (TNE) is a relatively new diagnostic procedure in the evaluation of patients with globus sensation and dysphagia. Enabling doctors to examine all of the upper aerodigestive system without the need for sedation, this technique is becoming more popular among otolaryngology specialists. The aim of this study is to evaluate the practicabi... περισσότερα »
Does CPAP treatment lead to gastroesophageal reflux in patients with moderate and severe OSA?
*Does CPAP treatment lead to gastroesophageal reflux in patients with moderate and severe OSA?* Eur Arch Otorhinolaryngol. 2016 Jun 22; Authors: Ozcelik H, Kayar Y, Danalioglu A, Arabaci E, Uysal O, Yakar F, Kart L Abstract Obstructive sleep apnea (OSA) leads to upper respiratory tract obstruction, causing increased abdominal-gastric pressure and decreased lower esophageal sphincter (LES) pressure and thus gastroesophageal reflux (GER). Continuous positive airway pressure (CPAP) is known to be an effective method for OSA treatment, but its effect on GER is still controversial. Th... περισσότερα »
The development of a new questionnaire for cognitive complaints in vertigo: the Neuropsychological Vertigo Inventory (NVI).
*The development of a new questionnaire for cognitive complaints in vertigo: the Neuropsychological Vertigo Inventory (NVI).* Eur Arch Otorhinolaryngol. 2016 Jun 22; Authors: Lacroix E, Deggouj N, Salvaggio S, Wiener V, Debue M, Edwards MG Abstract Vertigo patients frequently complain of emotional and associated cognitive problems, yet currently, there is no satisfactory questionnaire to measure these associated problems. In the present paper, we propose a new internet-based Neuropsychological Vertigo Inventory (NVI; French) that evaluates attention, memory, emotion, space percept... περισσότερα »
Calculating annoyance: an option to proof efficacy in ENT treatment of snoring?
*Calculating annoyance: an option to proof efficacy in ENT treatment of snoring?* Eur Arch Otorhinolaryngol. 2016 Jun 22; Authors: Fischer R, Kuehnel TS, Merz AK, Ettl T, Herzog M, Rohrmeier C Abstract To develop and validate an objective method for calculating the annoyance caused by snoring sounds. 53 subjects assessed 50 different snoring and breath sounds on a visual analog scale for level of annoyance. A linear regression analysis was used to correlate these subjective assessments with objectively calculated psychoacoustic parameters (loudness, roughness, sharpness, and fluc... περισσότερα »
Acoustic and tongue kinematic vowel space in speakers with and without dysarthria
10.1080/17549507.2016.1193899<br>Jimin Lee from Speech via xlomafota13 on Inoreader http://ift.tt/28RtVpN
Improving selection of synsets from WordNet for domain-specific word sense disambiguation
[image: alertIcon.gif] Publication date: Available online 23 June 2016 *Source:*Computer Speech & Language Author(s): Ivan Lopez-Arevalo, Victor J. Sosa-Sosa, Franco Rojas-Lopez, Edgar Tello-Leal Word Sense Disambiguation (WSD) is a fundamental task useful for Information Retrieval, Information Extraction, web search, indexing, among others. In the literature there exist several works dedicated to generic WSD task, but in recent years domain-specific WSD has attracted the attention of several researchers. In this sense, this paper describes an approach for domain-specific WSD by sel... περισσότερα »
Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 26 δευτερόλεπτα
Abstract Purpose Monocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity e... περισσότερα »
Microsurgical management of primary jugular foramen meningiomas: a series of 22 cases and review of the literature.
*Microsurgical management of primary jugular foramen meningiomas: a series of 22 cases and review of the literature.* Neurosurg Rev. 2016 Jun 23; Authors: Tang J, Zhang L, Zhang J, Wu Z, Xiao X, Zhou D, Jia G, Jia W Abstract This study summarized clinical manifestations, surgical management, histological grading, and long-term outcome of jugular foramen meningiomas (JFMs). Retrospective study was performed in 22 consecutive patients with primary JFMs from January 2004 to October 2010, enrolling 10 men and 12 women with average age of 39.4 (14-57 years). The most common initial sy... περισσότερα »
SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
[image: cover.gif?v=1&s=7ed1ee29e575b52989bb5c85] Invariant Natural Killer T (iNKT) cells differentiate in the thymus into three distinct lineages defined by their cytokine and transcription factor expression. SLAM-associated protein (SAP) is essential for early stages of iNKT cell development, but its role during terminal differentiation of iNKT1, iNKT2 or iNKT17 cells remains unclear. Taking advantage of SAP-deficient mice expressing a Vα14-Jα18 TCRα transgene, we found that SAP is critical not only for IL-4 production but also for the terminal differentiation of IL-4-producing ... περισσότερα »
The Lingual Artery in Healthy Tongue
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Histopathologic Evaluations of the Lingual Artery in Healthy Tongue of Adult Cadaver.: Clin Exp Otorhinolaryngol. 2016 Jun ; Authors: Mun MJ, Lee CH, Lee BJ, Lee JC, Jang JY, Jung SH, Wang SG Abstract Objectives: To clarify the anatomical distribution of the lingual artery in normal adult subjects through histopathologic evaluations. Methods: Eighteen healthy cadaveric […]
Endoscopic Tympanoplasty to Microscopic Tympanoplasty.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Comparison of Clin Exp Otorhinolaryngol. 2016 Jun ; Authors: Choi N, Noh Y, Park W, Lee JJ, Yook S, Choi JE, Chung WH, Cho YS, Hong SH, Moon IJ Abstract Objectives: This study aimed to compare the outcome of endoscopic and microscopic tympanoplasty. Methods: This was a retrospective comparative study of 73 patients (35 males […]
Upper Airway Variation and Frequent Alcohol Consumption
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Can Affect Compliance With Continuous Positive Airway Pressure.: Clin Exp Otorhinolaryngol. 2016 Jun ; Authors: Jeong JI, Kim HY, Hong SD, Ryu G, Kim SJ, Lee KE, Dhong HJ, Chung SK Abstract Objectives: Compliance with continuous positive airway pressure (CPAP) treatment remains a primary concern for improving treatment outcomes of obstructive sleep apnea. There are […]
A New Surgical Approach for Direct Acoustic Cochlear Implant
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
A Temporal Bone Study.: Clin Exp Otorhinolaryngol. 2016 Jun ; Authors: Bruschini L, Forli F, Vito A, Berrettini S Abstract Objectives: The direct acoustic cochlear implant (DACI) is among the latest developments in the field of implantable acoustic prostheses. The surgical procedure requires a mastoidectomy and a posterior-inferior tympanotomy, with access to the facial recess […]
Adult Patients With Peritonsillar Abscess.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Initial Factors Influencing Duration of Hospital Stay in Clin Exp Otorhinolaryngol. 2016 Jun ; Authors: Liu YH, Su HH, Tsai YW, Hou YY, Chang KP, Chi CC, Lin MY, Wu PH Abstract Objectives: To review cases of peritonsillar abscess and investigate the initial clinical factors that may influence the duration of hospitalization. To determine the […]
Painful Temporomandibular Disorder
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Decade of Discovery from OPPERA Studies: In 2006, the OPPERA project (Orofacial Pain: Prospective Evaluation and Risk Assessment) set out to identify risk factors for development of painful temporomandibular disorder (TMD). A decade later, this review summarizes its key findings. At 4 US study sites, OPPERA recruited and examined 3,258 community-based TMD-free adults assessing genetic […]
Squamous cell carcinoma (SCC) – Cancer – Melanoma – Allergy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
now Allergy and Immunology by Alexandros G.Sfakianakis Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease Abstract Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive […]
OtoRhinoLaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
3h OtoRhinoLaryngology – Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Return to Work and Social Communication Ability Following Severe Traumatic Brain Injury Purpose Return to competitive employment presents a major challenge to adults who survive traumatic brain injury (TBI). This study was undertaken to better understand factors that shape employment outcome by comparing […]
Results with Expanded Endonasal Resection of Skull Base Meningiomas: Technical Nuances and Approach Selection Based on an Early Experience.
*Results with Expanded Endonasal Resection of Skull Base Meningiomas: Technical Nuances and Approach Selection Based on an Early Experience.* Turk Neurosurg. 2016 Jan 25; Authors: Sughrue M, Bonney P, Burks J, Hayhurst C, Gore P, Teo C Abstract AIM: Reconstruction technique advances have created renewed enthusiasm for the expanded endonasal approach (EEA). However, as with any new technique, early experiences inevitably lead to more selective use of these techniques. We review our experience of the expanded endonasal endoscopic approach for skull base meningiomas and place it in c... περισσότερα »
Management of Calvarial Tumors - a retrospective analysis and literature review.
*Management of Calvarial Tumors - a retrospective analysis and literature review.* Turk Neurosurg. 2015 Jul 6; Authors: Özgiray E, Perumal K, Çinar C, Emre Çaliskan K, Ertan Y, Yurtseven T, Oktar N, Övül I, Öner K Abstract AIM: Tumors of various organs which metastasize to bone do not neglect calvarium as a target. The aim of this study is to characterize the calvarial tumors. MATERIAL AND METHODS: We retrospectively reviewed 45 consecutive patients operated for calvarial masses from October 1996 till May 2012 at our hospital. Skull base tumors and patients ≤18 years were exclu... περισσότερα »
Does where you live influence how your vestibular schwannoma is managed? Examining geographical differences in vestibular schwannoma treatment across the United States.
*Does where you live influence how your vestibular schwannoma is managed? Examining geographical differences in vestibular schwannoma treatment across the United States.* J Neurooncol. 2016 Jun 22; Authors: Carlson ML, Glasgow AE, Grossardt BR, Habermann EB, Link MJ Abstract The management of small- to medium-sized vestibular schwannoma (VS) remains controversial. Despite a lack of compelling evidence supporting one treatment modality over others, many providers and institutions remain highly biased toward one particular therapy-microsurgery, radiation, or primary observation. Th... περισσότερα »
Temporal aneurysmal bone cyst: cost-effective method to achieve gross total resection.
*Temporal aneurysmal bone cyst: cost-effective method to achieve gross total resection.* Acta Neurochir (Wien). 2016 Jun 22; Authors: Sodhi HB, Salunke P, Agrawal P, Gupta K Abstract Aneurysmal bone cyst (ABC) is a vascular benign bony expansile lesion. The treatment is gross total resection. Surgery for a skull base aneurysmal bone cyst poses a significant challenge because of its vascularity and the adjacent neurovascular structures. We present the case of a young male with a temporal aneurysmal bone cyst who underwent gross total resection of the lesion. The external carotid a... περισσότερα »
Acoustic and tongue kinematic vowel space in speakers with and without dysarthria.
*Acoustic and tongue kinematic vowel space in speakers with and without dysarthria.* Int J Speech Lang Pathol. 2016 Jun 23;:1-10 Authors: Lee J, Littlejohn MA, Simmons Z Abstract PURPOSE: The purpose is to investigate acoustic and tongue body kinematic vowel dispersion patterns and vowel space in speakers with and without dysarthria secondary to amyotrophic lateral sclerosis (ALS). METHOD: Acoustic and tongue kinematic vowel spaces were examined at the same time sampling point using electromagnetic articulography in 11 speakers with dysarthria secondary to ALS and 11 speakers with... περισσότερα »
The role of transient receptor potential channels in hypertension and metabolic vascular damage
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 47 δευτερόλεπτα
Intracellular Ca2+ homeostasis is critical for vascular function and metabolism regulation. Metabolic disorders are major risk factors for hypertension. A family of transient receptor potential (TRP) channels plays an important role in the regulation of cellular calcium signaling and cardiometabolic function. Emerging evidence indicates that TRP channels are highly implicated in the pathogenesis of hypertension and metabolic disorders. Dysfunction of TRP channels leads to hypertension and metabolic dysfunction. Activation of certain subtypes of TRP channels could attenuate metabo... περισσότερα »
Intrapulmonary arteriovenous anastomoses in humans with chronic obstructive pulmonary disease: implications for cryptogenic stroke?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 47 δευτερόλεπτα
*INTRODUCTION*: The pulmonary capillaries prevent stroke by filtering venous emboli from the circulation. Intrapulmonary arteriovenous anastomoses are large diameter (≥ 50μm) vascular connections in the lung that may compromise the integrity of the pulmonary capillary filter and have been recently linked to cryptogenic stroke and transient ischemic attack. Prothrombotic populations, such as individuals with chronic obstructive pulmonary disease (COPD) may be at increased risk of stroke and transient ischemic attack facilitated by intrapulmonary arteriovenous anastomoses, but the ... περισσότερα »
A novel mutant Na+/HCO3− cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 47 δευτερόλεπτα
Abstract Proximal Renal Tubular Acidosis (pRTA) is a rare, recessively-inherited disease characterized by abnormally acidic blood, blindness, and below average height and weight. pRTA is typically associated with homozygous mutation of *SLC4A4*. *SLC4A4* encodes the electrogenic sodium bicarbonate cotransport protein NBCe1, a membrane protein that acts to maintain intracellular and plasma pH. We present the first description of a case of compound-heterozygous inheritance of pRTA. The individual has inherited two mutations in NBCe1: p. Arg510His (R510H) and p.Gln913Arg (Q913R), one ... περισσότερα »
Age-Related Changes in Antioxidative Enzyme Capacity in Tongue of Fischer 344 Rats.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Age-Related Changes in Antioxidative Enzyme Capacity in Tongue of Fischer 344 Rats. Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Baek MK, Kim KO, Kwon HJ, Kim YW, Woo JH, Kim DY Abstract Objectives: Antioxidative enzyme efficiency changes in some organs with age. However, no study has been conducted on age-related antioxidant enzyme changes in tongue. […]
Initial Factors Influencing Duration of Hospital Stay in Adult Patients With Peritonsillar Abscess.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Initial Factors Influencing Duration of Hospital Stay in Adult Patients With Peritonsillar Abscess. Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Liu YH, Su HH, Tsai YW, Hou YY, Chang KP, Chi CC, Lin MY, Wu PH Abstract Objectives: To review cases of peritonsillar abscess and investigate the initial clinical factors that may influence the duration […]
Upper Airway Variation and Frequent Alcohol Consumption Can Affect Compliance With Continuous Positive Airway Pressure.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Upper Airway Variation and Frequent Alcohol Consumption Can Affect Compliance With Continuous Positive Airway Pressure. Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Jeong JI, Kim HY, Hong SD, Ryu G, Kim SJ, Lee KE, Dhong HJ, Chung SK Abstract Objectives: Compliance with continuous positive airway pressure (CPAP) treatment remains a primary concern for improving treatment […]
Comparison of Endoscopic Tympanoplasty to Microscopic Tympanoplasty.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Comparison of Endoscopic Tympanoplasty to Microscopic Tympanoplasty. Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Choi N, Noh Y, Park W, Lee JJ, Yook S, Choi JE, Chung WH, Cho YS, Hong SH, Moon IJ Abstract Objectives: This study aimed to compare the outcome of endoscopic and microscopic tympanoplasty. Methods: This was a retrospective comparative study […]
Histopathologic Evaluations of the Lingual Artery in Healthy Tongue of Adult Cadaver.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Histopathologic Evaluations of the Lingual Artery in Healthy Tongue of Adult Cadaver. Clin Exp Otorhinolaryngol. 2016 Jun 18; Authors: Mun MJ, Lee CH, Lee BJ, Lee JC, Jang JY, Jung SH, Wang SG Abstract Objectives: To clarify the anatomical distribution of the lingual artery in normal adult subjects through histopathologic evaluations. Methods: Eighteen healthy cadaveric […]
Dermatology Handbook Reviews
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XahcJ via IFTTT
Your breath and what it tells about your body – Times of India
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Your breath and what it tells about your body Times of India Cancer thrives in bodies that are acidic in nature. Moreover, as … Brush teeth twice a day – Flush and rinse teeth after every meal – Clean tongue regularly with a neat tongue cleaner – Use anti bacterial mouth wash either half an […]
Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Guillem Pascual-Pasto, Nagore G. Olaciregui, Monica Vila-Ubach, Sonia Paco, Carles Monterrubio, Eva Rodriguez, Ursula Winter, Mireia Batalla-Vilacis, Jaume Catala, Hector Salvador, Andreu Parareda, Paula Schaiquevich, Mariona Suñol, Jaume Mora, Cinzia Lavarino, Carmen de Torres, Guillermo L. Chantada, Angel M. Carcaboso Translational research in […]
The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Qiwei Wang, Xiaotian Zhang, Enyun Shen, Jing Gao, Fengqi Cao, Xiaojuan Wang, Yilin Li, Tiantian Tian, Jingyuan Wang, Zuhua Chen, Jiayuan Wang, Lin Shen The anti-HER2 monoclonal antibody trastuzumab is central to the treatment of HER2-positive gastric cancer (GC); however, its responses are […]
F25P preproinsulin abrogates the secretion of pro-growth factors from EGFRvIII cells and suppresses tumor growth in an EGFRvIII/wt heterogenic model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Jian-wei Wei, Jing-qiu Cui, Xuan Zhou, Chuan Fang, Yan-li Tan, Lu-yue Chen, Chao Yang, Ming Liu, Chun-sheng Kang Extensive heterogeneity is a defining hallmark of glioblastoma multiforme (GBM) at the cellular and molecular levels. EGFRvIII, the most common EGFR mutant, is expressed in […]
Feasibility and Utility of Chest-X ray on Portable Normothermic Perfusion System.
No abstract available from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28ULJlX
Safeguarding Fertility With Whole Ovary Cryopreservation and Microvascular Transplantation: Higher Follicular Survival With Vitrification Than With Slow Freezing in a Ewe Model.
Background: In young women, ovarian cortex cryopreservation before gonadotoxic chemotherapy and its avascular grafting after cancer healing permitted fertility restoration. However, ischemia reduced the grafts' lifespan. Microvascular transplantation of cryopreserved whole ovary may allow immediate revascularization, ensuring better fertility preservation, but the best cryopreservation method is unknown. We aimed to compare slow freezing and vitrification of whole ovary for fertility preservation purposes, in an ewe model. Methods: Twelve ewes were allocated at random to slow freezi... περισσότερα »
Association of Pretransplant Skin Cancer With Posttransplant Malignancy, Graft Failure and Death in Kidney Transplant Recipients.
Background: Posttransplant malignancy (PTM) is one of the leading causes of late death in kidney recipients. Those with a cancer history may be more prone to develop a recurrent or a new cancer. We studied the association between pretransplant skin cancer, PTM, death, and graft failure. Methods: Primary adult kidney recipients transplanted between 2005 and 2013 were included. Malignancy information was obtained from Organ Procurement Kidney Transplant Network/United Network for Organ Sharing registration and follow-up forms. Posttransplant malignancy was classified into skin cancer, ... περισσότερα »
Long-Term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
Background: Limited data are available regarding the long-term metabolic outcomes of functioning pancreas transplants in patients with type 2 diabetes mellitus (T2DM). Methods: To compare the long-term effects of pancreas transplantation in terms of insulin resistance and [beta] cell function, comparison of metabolic variables was performed between type 1 diabetes mellitus (T1DM) and T2DM patients from 1-month posttransplant to 5 years using generalized, linear-mixed models for repeated measures. Results: Among 217 consecutive patients who underwent pancreas transplantation at our c... περισσότερα »
Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.
Background: In virtual crossmatch (XM) strategies, a correct anticipation of XM results is required for appropriately allocating organs. We reassessed the ability to predict T lymphocyte flow cytometry and complement dependent cytotoxicity XM results with the mean fluorescence intensity (MFI) in Luminex class I single antigen flow beads (SAFB) assay, after correction of complement interference and exclusion of antidenatured HLA antibodies. Methods: Among 432 XM with T lymphocytes (T-XM), 407 were analyzed after exclusion of antidenatured HLA antibodies. Only ethylenediaminetetraacet... περισσότερα »
Changing Indications in Penetrating Keratoplasty: A Systematic Review of 34 Years of Global Reporting.
Background: Penetrating keratoplasty (PK) ranks among the oldest and most common kinds of human tissue transplantation. Based on the hypothesis that reported indications for PK significantly vary between global regions and over time, the present systematic review aimed to provide a thorough overview of global PK indications as reported in peer-reviewed manuscripts. Methods: A literature search of PubMed and MEDLINE was conducted to retrieve articles published from January 1980 to May 2014. Indications for PK within 7 global regions were compared using a modified classification syste... περισσότερα »
Handlungsempfehlung zur Behandlung thermisch verletzter Kinder
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Po1m7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Guillem Pascual-Pasto, Nagore G. Olaciregui, Monica Vila-Ubach, Sonia Paco, Carles Monterrubio, Eva Rodriguez, Ursula Winter, Mireia Batalla-Vilacis, Jaume Catala, Hector Salvador, Andreu Parareda, Paula Schaiquevich, Mariona Suñol, Jaume Mora, Cinzia Lavarino, Carmen de Torres, Guillermo L. Chantada, Angel M. Carcaboso Translational research in […]
The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Qiwei Wang, Xiaotian Zhang, Enyun Shen, Jing Gao, Fengqi Cao, Xiaojuan Wang, Yilin Li, Tiantian Tian, Jingyuan Wang, Zuhua Chen, Jiayuan Wang, Lin Shen The anti-HER2 monoclonal antibody trastuzumab is central to the treatment of HER2-positive gastric cancer (GC); however, its responses are […]
F25P preproinsulin abrogates the secretion of pro-growth factors from EGFRvIII cells and suppresses tumor growth in an EGFRvIII/wt heterogenic model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 September 2016 Source:Cancer Letters, Volume 380, Issue 1 Author(s): Jian-wei Wei, Jing-qiu Cui, Xuan Zhou, Chuan Fang, Yan-li Tan, Lu-yue Chen, Chao Yang, Ming Liu, Chun-sheng Kang Extensive heterogeneity is a defining hallmark of glioblastoma multiforme (GBM) at the cellular and molecular levels. EGFRvIII, the most common EGFR mutant, is expressed in […]
Power Comparisons of Methods for Joint Association Analysis of Multiple Phenotypes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background/Aims: Genome-wide association studies (GWAS) have identified many variants that each affect multiple phenotypes, which suggests that pleiotropic effects on human complex phenotypes may be widespread. Therefore, statistical methods that can jointly analyze multiple phenotypes in GWAS may have advantages over analyzing each phenotype individually. Several statistical methods have been developed to utilize such multivariate […]
The roles and implications of exosomes in sarcoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Better diagnostic biomarkers and therapeutic options are still necessary for patients with sarcomas due to the current limitations of diagnosis and treatment. Exosomes are small extracellular membrane vesicles that are released by various cells and are found in most body fluids. Tumor-derived exosomes have been proven to mediate tumorigenesis, intercellular communication, microenvironment modulation, and […]
Antibiotics, Vol. 5, Pages 22: Techniques for Screening Translation Inhibitors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The machinery of translation is one of the most common targets of antibiotics. The development and screening of new antibiotics usually proceeds by testing antimicrobial activity followed by laborious studies of the mechanism of action. High-throughput methods for new antibiotic screening based on antimicrobial activity have become routine; however, identification of molecular targets is usually […]
ISSN Society News
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
J Nutrigenet Nutrigenomics 2016;9:62 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Stafx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
ISSN Membership Application Form
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
J Nutrigenet Nutrigenomics 2016;9:63 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28UWqVM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly in comparison to that of HNSCC, which is associated with the use of tobacco or alcohol or both. This increase has resulted mainly from the global rise in the number […]
Concentration Response Modeling of ECG Data from Early Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT risk - Experience from the Development Program of Lemborexant
[image: cover.gif?v=1&s=cf04ac26a9387c4e45e51322] Abstract Lemborexant is a novel dual orexin receptor antagonist being developed to treat insomnia. Its potential to cause QT prolongation was evaluated using plasma concentration response (CR) modeling applied to data from two multiple ascending dose (MAD) studies. In the primary MAD study, placebo or lemborexant (2.5 to 75 mg) was administered for 14 consecutive nights. In another MAD study designed to "bridge" pharmacokinetic and safety data between Japanese and non-Japanese subjects (J-MAD), placebo or lemborexant (2.5, 10, or ... περισσότερα »
Role of FoxQ1 in bCSC Inhibition by DATS Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Diallyl trisulfide (DATS), a metabolic byproduct of garlic, is known to inhibit the growth of breast cancer cells in vitro and in vivo. This study demonstrates that DATS targets breast cancer stem cells (bCSC). Exposure of MCF-7 and SUM159 human breast cancer cells to pharmacological concentrations of DATS (2.5 and 5 μm) resulted in dose-dependent […]
Structural Organization of Mec1{middle dot}Ddc2 and Tel1 DNA and Chromosomes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural insight for dimers of Mec1·Ddc2 and Tel1 using single-particle electron microscopy. Both […]
Substrate Specificity of PRDM7 Enzymology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
PR domain-containing protein 7 (PRDM7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. The two proteins are highly homologous, especially in the catalytic PR/SET domain, where they differ by only three amino acid residues. Here we report that PRDM7 is an efficient methyltransferase that selectively catalyzes the […]
Thiopurine-mediated Immunosuppression of T Lymphocytes Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
6-Thiopurine (6-TP) prodrugs include 6-thioguanine and azathioprine. Both are widely used to treat autoimmune disorders and certain cancers. This study showed that a 6-thioguanosine triphosphate (6-TGTP), converted in T-cells from 6-TP, targets Rac1 to form a disulfide adduct between 6-TGTP and the redox-sensitive GXXXXGK(S/T)C motif of Rac1. This study also showed that, despite the conservation […]
Folded State of Tat-dependently Translocated CueO Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In Escherichia coli, cytoplasmic copper ions are toxic to cells even at the lowest concentrations. As a defense strategy, the cuprous oxidase CueO is secreted into the periplasm to oxidize the more membrane-permeable and toxic Cu(I) before it can enter the cytoplasm. CueO itself is a multicopper oxidase that requires copper for activity. Because it […]
miR-214 Regulates Dendrite Development by Targeting Qki Cell Biology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Proper dendritic elaboration of neurons is critical for the formation of functional circuits during brain development. Defects in dendrite morphogenesis are associated with neuropsychiatric disorders, and microRNAs are emerging as regulators of aspects of neuronal maturation such as axonal and dendritic growth, spine formation, and synaptogenesis. Here, we show that miR-214 plays a pivotal role […]
Investigation of the TOCA1-Cdc42 Interaction Protein Structure and Folding
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Transducer of Cdc42-dependent actin assembly protein 1 (TOCA1) is an effector of the Rho family small G protein Cdc42. It contains a membrane-deforming F-BAR domain as well as a Src homology 3 (SH3) domain and a G protein-binding homology region 1 (HR1) domain. TOCA1 binding to Cdc42 leads to actin rearrangements, which are thought to […]
Interaction between Amphiphilic Neamine Derivatives and Lipids Membrane Biology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct protein and lipid assemblies. Evidence suggests that cardiolipin molecules segregate into such microdomains, probably conferring a negative curvature to the inner plasma membrane during membrane fission upon cell division. 3′,6-Dinonyl neamine is an amphiphilic aminoglycoside derivative active against Pseudomonas aeruginosa, including strains resistant to […]
rTRPV1 Tyr511 Entraps Exo- and Endovanilloids in the VBS Neurobiology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Vanilloids are pain evoking molecules that serve as ligands of the “heat and capsaicin receptor” TRPV1. Binding of either endogenous or exogenous vanilloids evokes channel and subsequent neuronal activation, leading to pain sensation. Despite its pivotal physiological role, the molecular basis of TRPV1 activation and deactivation is not fully understood. The highly conserved tyrosine in […]
Regulation of PKC{zeta} by Scaffolding Interactions Enzymology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Atypical protein kinase C (aPKC) isozymes modulate insulin signaling and cell polarity, but how their activity is controlled in cells is not well understood. These enzymes are constitutively phosphorylated, insensitive to second messengers, and have relatively low activity. Here we show that protein scaffolds not only localize but also differentially control the catalytic activity of […]
A New Bioactive Eicosanoid Generated by Human Platelets Enzymology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to formylmethionylleucylphenylalanine. Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic […]
sFRP2 Modulates Non-canonical Wnt Signaling Signal Transduction
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Convergent extension movements during vertebrate gastrulation require a balanced activity of non-canonical Wnt signaling pathways, but the factors regulating this interplay on the molecular level are poorly characterized. Here we show that sFRP2, a member of the secreted frizzled-related protein (sFRP) family, is required for morphogenesis and papc expression during Xenopus gastrulation. We further provide […]
EHD3 Stabilizes Tubular Recycling Endosomes Membrane Biology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
An elaborate network of dynamic lipid membranes, termed tubular recycling endosomes (TRE), coordinates the process of endocytic recycling in mammalian cells. The C-terminal Eps15 homology domain (EHD)-containing proteins have been implicated in the bending and fission of TRE, thus regulating endocytic recycling. EHD proteins have an EH domain that interacts with proteins containing an NPF […]
ZNF618 Is a Unique Functional Partner of UHRF2 Cell Biology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
5-Hydroxymethylcytosine (5hmC) is an epigenetic modification that is generated by ten-eleven translocation (TET) protein-mediated oxidation of 5-methylcytosine (5mC). 5hmC is associated with transcription regulation and is decreased in many cancers including melanoma. Accumulating evidence has suggested that 5hmC is functionally distinct from 5mC. Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) is the first […]
Accelerated Degradation of HMG-CoA Reductase in the Liver Protein Synthesis and Degradation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Accumulation of sterols in endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which catalyzes a rate-limiting step in synthesis of cholesterol. This ubiquitination marks HMGCR for proteasome-mediated degradation and constitutes one of several mechanisms for feedback control of cholesterol synthesis. Mechanisms for sterol-accelerated ubiquitination and degradation of HMGCR have been elucidated […]
Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer
Summary What is known and Objective Research has indicated that some Chinese herb injections (CHIs) might be beneficial in combination with chemotherapy, including remedies that might be used as effective chemosensitizers and radiosensitizers, or as palliative therapy. Here, we carried out a network meta-analysis to assess the clinical efficacy and safety of CHIs combined with oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) for advanced colorectal cancer (CRC). Methods PubMed, EMBASE.com, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literat... περισσότερα »
Utilization of antithrombotic therapy for stroke prevention in atrial fibrillation: a cross-sectional baseline analysis in general practice
Summary What is known and objective: Antithrombotics for stroke prevention in atrial fibrillation (AF) are reportedly underutilised. Since the burden of care lies within general practice, attention must be paid to identifying and addressing practice gaps in this setting. The objective of this study was to determine the contemporary utilisation of antithrombotic therapy for stroke prevention in AF within Australian general practice (GP). Methods: Data pertaining to AF patients' (aged ≥65 years) were collected from GP surgeries in New South Wales, Australia, using purpose-designed da... περισσότερα »
Clinico-genetics in Korean Charcot-Marie-Tooth disease type 2Z with MORC2 mutations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28UQQmG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30–60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins […]
Editorial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28PH8OA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimers disease model mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Identifying preventive targets for Alzheimer’s disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer’s disease in normal ageing populations. This preventive effect coincides with an extended preclinical phase that spans years to decades before onset of cognitive decline. In […]
Your nose knows how to target brain inflammation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28UQKv4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Temporal plus epilepsy is a major determinant of temporal lobe surgery failures
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28URnoo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A vulnerability to chronic pain and its interrelationship with resistance to analgesia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28PH6WV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Corticolimbic anatomical characteristics predetermine risk for chronic pain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
See Tracey (doi:10.1093/brain/aww147) for a scientific commentary on this article. Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic […]
Influence of countermeasures on the validity of the Concealed Information Test
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract The Concealed Information Test (CIT) is a psychophysiological technique that allows for detecting crime-related knowledge. Usually, autonomic response measures are used for this purpose, but ocular measures have also been proposed recently. Prior studies reported heterogeneous results for the usage of countermeasures (CM) to corrupt the CIT's validity, depending on the CM technique and the dependent measure. The current study systematically compared the application of physical and mental CM on autonomic and ocular measures during the CIT. Sixty participants committed a mo... περισσότερα »
A functional classification of medial frontal negativity ERPs: Theta oscillations and single subject effects
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Theta oscillations in the EEG have been linked to several ERPs that are elicited during performance-monitoring tasks, including the error-related negativity (ERN), no-go N2, and the feedback-related negativity (FRN). We used a novel paradigm to isolate independent components (ICs) in single subjects' (*n* = 27) EEG accounting for a medial frontal negativity (MFN) to response cue stimuli that signal a potential change in future response demands. Medial frontal projecting ICs that were sensitive to these response cues also described the ERNs, no-go N2s, and, to a lesser exte... περισσότερα »
Critical role of regulator of calcineurin 1 in spinal cord injury
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Spinal cord injury (SCI) is a severe clinical problem worldwide. The pathogenesis of SCI is complicated and much is unknown. The current study was designed to investigate the possible role of regulator of calcineurin 1 (RCAN1) in SCI and to explore the possible molecular mechanisms. Rats were injected with LVshRNAi-RCAN1 and then contusion-induced SCI was established. We found that RCAN1 was significantly increased in spinal cord of rats with SCI. Knockdown of RCAN1 markedly facilitated the structural and functional recovery in the spinal cord, as illustrated by decrease o... περισσότερα »
Attending Physician Adherence to a 29-Component Central Venous Catheter Bundle Checklist During Simulated Procedures.
[image: wk-health-logo.gif] Objectives: Central venous catheter insertions may lead to preventable adverse events. Attending physicians' central venous catheter insertion skills are not assessed routinely. We aimed to compare attending physicians' simulated central venous catheterinsertion performance to published competency standards. Design: Prospective cohort study of attending physicians' simulated internal jugular and subclavian central venous catheter insertion skills versus a historical comparison group of residents who participated in simulation training. Setting: Fifty-eig... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,June 24th,2016
Anesthetic management of a patient with polycythemia vera for neurosurgery otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα Anesthetic management of a patient with polycythemia vera for neurosurgery: Abstract Polycythemia vera (PV) is a myeloproliferative disorder characterized by excess red cell clonality. The increased number of red blood cells can lead to increased viscosity of the blood and ultimately compromise the blood supply to the end organ... περισσότερα »
Attending Physician Adherence to a 29-Component Central Venous Catheter Bundle Checklist During Simulated Procedures.
[image: wk-health-logo.gif] Objectives: Central venous catheter insertions may lead to preventable adverse events. Attending physicians' central venous catheter insertion skills are not assessed routinely. We aimed to compare attending physicians' simulated central venous catheterinsertion performance to published competency standards. Design: Prospective cohort study of attending physicians' simulated internal jugular and subclavian central venous catheter insertion skills versus a historical comparison group of residents who participated in simulation training. Setting: Fifty-eig... περισσότερα »
