Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges.
*Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges.* Cancer Treat Rev. 2016 Jun 7;48:20-24 Authors: Tartari F, Santoni M, Burattini L, Mazzanti P, Onofri A, Berardi R Abstract Anti-programmed death (PD)-1 agents pembrolizumab and nivolumab have recently obtained enthusiastic results in terms of progression-free survival (PFS), overall survival (OS) and tolerability in cancer patients. Despite these promising data, the high cost of these agents needs careful consideration. Indeed, the evaluation of cost... περισσότερα »
Pancreatic melanoma metastasis diagnosed by endoscopic ultrasound-guided SharkCore biopsy.
*Pancreatic melanoma metastasis diagnosed by endoscopic ultrasound-guided SharkCore biopsy.* Endoscopy. 2016 0;48(S 01):E208-E209 Authors: Nadal E, Burra P, Mescoli C, Albertoni L, Sperti C, Sturniolo GC, Fantin A PMID: 27310890 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/1YwUSC9
Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: about mutation-specific immunohistochemistry: reply from the authors.
*Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: about mutation-specific immunohistochemistry: reply from the authors.* Br J Dermatol. 2016 Jun 16; Authors: Shitara D, Tell-Martí G, Badenas C, Enokihara MM, Alós L, Larque AB, Michalany N, Puig-Butille JA, Carrera C, Malvehy J, Puig S, Bagatin E PMID: 27310877 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/23fQrwf
The chemokine (C-C motif) ligand protein synthesis inhibitor bindarit prevents cytoskeletal rearrangement and contraction of human mesangial cells.
*The chemokine (C-C motif) ligand protein synthesis inhibitor bindarit prevents cytoskeletal rearrangement and contraction of human mesangial cells.* Cytokine. 2016 Jun 13;85:92-100 Authors: Paccosi S, Giachi M, Di Gennaro P, Guglielmotti A, Parenti A Abstract Intraglomerular mesangial cells (MCs) maintain structural and functional integrity of renal glomerular microcirculation and homeostasis of mesangial matrix. Following different types of injury, MCs change their phenotype upregulating the expression of α-smooth muscle actin (α-SMA), changing contractile abilities and increas... περισσότερα »
Serum lactate dehydrogenase is a predictor of poor survival in malignant melanoma.
*Serum lactate dehydrogenase is a predictor of poor survival in malignant melanoma.* Panminerva Med. 2016 Jun 16; Authors: Gao D, Ma X Abstract BACKGROUND: Recently, different studies suggested that the elevated serum concentration of lactate dehydrogenase (LDH) was associated with poor prognosis of melanoma. However, the results were controversial. Thus, we decided to perform a meta-analysis to assess the association between serum concentration of LDH and the overall survival (OS) of melanoma. METHODS: Online electronic databases (PubMed, EMBASE, and Cochrane database) were sear... περισσότερα »
Immunostimulatory Monoclonal Antibodies and Immunomodulation: Harvesting the Crop.
*Immunostimulatory Monoclonal Antibodies and Immunomodulation: Harvesting the Crop.* Cancer Res. 2016 May 15;76(10):2863-2867 Authors: Berraondo P, Ochoa MC, Rodriguez-Ruiz ME, Minute L, Lasarte JJ, Melero I Abstract The recent approval by the FDA of the combination of anti-CTLA4 and anti-PD-1 mAbs for the treatment of BRAF-unmutated unresectable or metastatic melanoma is a landmark for the development of cancer immunotherapy. On October 18 to 22, 2015, a symposium was held in Pamplona (Spain) to present and discuss the basic and clinical discoveries that have brought us to this... περισσότερα »
Melanoma metastases caught in the AKT.
*Melanoma metastases caught in the AKT.* Mol Cell Oncol. 2016 Mar;3(2):e1128516 Authors: Kircher DA, Arave RA, Cho JH, Holmen SL Abstract Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context. PMID: 27308635 [PubMed] from Melanoma via xlomafota13 on Inoreader http://ift.tt/23fPYtY
Histone variant H2A.Z.2: A novel driver of melanoma progression.
*Histone variant H2A.Z.2: A novel driver of melanoma progression.* Mol Cell Oncol. 2016 Mar;3(2):e1073417 Authors: Vardabasso C, Hake SB, Bernstein E Abstract Histone variants are attracting attention in the field of cancer epigenetics. Our study has established a novel role for the uncharacterized histone variant H2A.Z.2 as a driver of malignant melanoma. H2A.Z.2 promotes cellular proliferation by recruiting BRD2 and E2F1 to E2F target genes and facilitating their transcription. High H2A.Z.2 expression correlates with poor survival in patients, and its depletion sensitizes cells ... περισσότερα »
Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature.
*Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature.* Mol Cell Oncol. 2016 Jan;3(1):e970097 Authors: Maes H, Kuchnio A, Carmeliet P, Agostinis P Abstract Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-ind... περισσότερα »
The double life of RIPK1.
*The double life of RIPK1.* Mol Cell Oncol. 2016 Jan;3(1):e1035690 Authors: Jin L, Chen J, Liu XY, Jiang CC, Zhang XD Abstract We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor. PMID: 27308554 [PubMed] from Melanoma via xlomafota13 on Inoreader http://ift.tt... περισσότερα »
Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimmers.
*Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimmers.* Mol Cell Oncol. 2016 Jan;3(1):e1033588 Authors: Premi S, Brash DE Abstract Ultraviolet radiation (UVR) instantaneously generates cyclobutane pyrimidine dimers (CPDs). Paradoxically, we recently observed that UV enables the protective pigment melanin to create CPDs in the dark long after the exposure ends. UV-induced reactive oxygen species (ROS) oxidize melanin to create melanin carbonyls in a high-energy quantum state. These energetic melanin carbonyls transfer their energy to DNA in the dark... περισσότερα »
The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors.
*The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors.* Mol Cell Oncol. 2016 Jan;3(1):e1021441 Authors: Lin L, Bivona TG Abstract RAF- and MEK-targeted therapies are approved for patients with BRAF(V600E) melanoma and under investigation in a several other tumor types, but resistance remains a major challenge. We uncovered yes-associated protein 1 (YAP1) as a mechanism of resistance to RAF-MEK inhibition in BRAF- and RAS-mutant cancers, providing a rationale for co-targeting YAP and RAF-MEK to enhance patient outcomes. PMID: 27308535 [PubMed] ... περισσότερα »
Inhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma.
*Inhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma.* Mol Cell Oncol. 2015 Oct-Dec;2(4):e1008291 Authors: Smalley KS, Fedorenko IV Abstract Recent analyses by our group and others showed that the majority of melanoma patients who fail BRAF inhibitor therapy do so at new disease sites. Using phosphoproteomics we showed that BRAF inhibition mediates a switch to an aggressive/metastatic melanoma phenotype that is driven by ligand-independent erythropoietin-producing hepatocellular receptor A2 (EphA2) signaling. PMID: 27308505 [PubMed] from Melanoma via xlomafot... περισσότερα »
Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma.
*Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma.* Mol Cell Oncol. 2015 Jul-Sep;2(3):e995016 Authors: Giglio P, Fimia GM, Lovat PE, Piacentini M, Corazzari M Abstract Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress r... περισσότερα »
Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition.
*Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition.* Mol Cell Oncol. 2015 Jul-Sep;2(3):e991610 Authors: McQuade JL, Vashisht Gopal Y Abstract Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings. PMID: 273084... περισσότερα »
Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe - a systematic review of the literature.
*Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe - a systematic review of the literature.* Clin Epidemiol. 2016;8:109-22 Authors: Svedman FC, Pillas D, Taylor A, Kaur M, Linder R, Hansson J Abstract BACKGROUND: Given the increasing incidence in cutaneous malignant melanoma (CMM) and the recent changes in the treatment landscape, it is important to understand stage-specific overall and recurrence-free survival patterns in Europe. Despite publications such as EUROCARE-5, there is limited information on stage-specific survival for CMM in... περισσότερα »
PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo.
*PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo.* Clin Cancer Res. 2016 Jun 15; Authors: Niessner H, Schmitz J, Tabatabai G, Schmid A, Calaminus C, Sinnberg T, Weide B, Eigentler TK, Garbe C, Schittek B, Quintanilla-Fend L, Bender B, Mai M, Praetorius C, Beissert S, Schackert G, Muders M, Meinhardt M, Baretton GB, Dummer R, Flaherty KT, Pichler BJ, Kulms D, Westphal D, Meier F Abstract PURPOSE: Great advances have recently been made in treating patients with metastatic melanoma. However, existing therapies are less eff... περισσότερα »
Risk of invasive melanoma in patients with rheumatoid arthritis treated with biologics: results from a collaborative project of 11 European biologic registers.
*Risk of invasive melanoma in patients with rheumatoid arthritis treated with biologics: results from a collaborative project of 11 European biologic registers.* Ann Rheum Dis. 2016 Jun 15; Authors: Mercer LK, Askling J, Raaschou P, Dixon WG, Dreyer L, Hetland ML, Strangfeld A, Zink A, Mariette X, Finckh A, Canhao H, Iannone F, Zavada J, Morel J, Gottenberg JE, Hyrich KL, Listing J Abstract OBJECTIVES: Some studies have reported a possible association between exposure to tumour necrosis factor (TNF) inhibitors and an increased risk of melanoma. The aim of this study was to invest... περισσότερα »
Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab.
*Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab.* Ann Rheum Dis. 2016 Jun 15; Authors: Cappelli LC, Gutierrez AK, Baer AN, Albayda J, Manno RL, Haque U, Lipson EJ, Bleich KB, Shah AA, Naidoo J, Brahmer JR, Le D, Bingham CO Abstract OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) pathways have demonstrated survival improvements in multiple advanced cancers, but also cause immune-related adverse events (IRAEs). IRAEs with clinical features sim... περισσότερα »
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis.
*The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis.* Cardiovasc Res. 2016 Jun 15; Authors: Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T Abstract AIMS: Controlling vascular integrity is expected to be a novel therapeutic target of cancers as well as cardiovascular diseases. Adrenomedullin (AM) and its receptor-modulating protein, RAMP2, have been identified as essential mediators of cardiovascular home... περισσότερα »
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma.
*Serum calcium, albumin and tumor stage in cutaneous malignant melanoma.* Future Oncol. 2016 Jun 16; Authors: Datta M, Savage P, Lovato J, Schwartz GG Abstract AIM: Assess the relationship of serum calcium and serum albumin to tumor stage and other clinical characteristics in patients with cutaneous malignant melanoma (MM). PATIENTS & METHODS: A cross-sectional study to evaluate serum calcium as a marker of disease progression (n = 644) in MM. RESULTS: Serum albumin was significantly lower among men (p < 0.01) and among patients with stage 4 disease (p < 0.05). In a multivariable ... περισσότερα »
Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events.
*Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events.* Oncologist. 2016 Jun 15; Authors: González-Rodríguez E, Rodríguez-Abreu D, Spanish Group for Cancer Immuno-Biotherapy (GETICA) Abstract : In recent years, immune checkpoint inhibitors have emerged as effective therapies for advanced neoplasias. As new checkpoint target blockers become available and additional tumor locations tested, their use is expected to increase within a short time. Immune-related adverse events (irAEs) affecting the endocrine system are among the most frequent and complex tox... περισσότερα »
Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges.
*Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges.* Cancer Treat Rev. 2016 Jun 7;48:20-24 Authors: Tartari F, Santoni M, Burattini L, Mazzanti P, Onofri A, Berardi R Abstract Anti-programmed death (PD)-1 agents pembrolizumab and nivolumab have recently obtained enthusiastic results in terms of progression-free survival (PFS), overall survival (OS) and tolerability in cancer patients. Despite these promising data, the high cost of these agents needs careful consideration. Indeed, the evaluation of cost... περισσότερα »
Registration Accuracy of CT/MRI Fusion for Localisation of Deep Brain Stimulation Electrode Position: An Imaging Study and Systematic Review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Background: Postoperative imaging is essential for verifying electrode location in patients undergoing deep brain stimulation (DBS). MRI offers better visualisation of brain targets, but concerns about adverse events have limited its use. Preoperative stereotactic MRI fused with a postoperative stereotactic CT, demonstrating the electrode position, is now widely used. Objectives: The aims of this study […]
I festivalmedisinens tjeneste
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Få tenker på legeyrket som sesongarbeid, men når andre tar ferie er det en gruppe leger som bare skifter beite. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UmV2Jm via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Behandling av gassembolier
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
– Helsedirektoratet har nylig utgitt et notat om gassembolier vi mener er mangelfullt, skriver kommentarforfattere. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Yx3WGX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Festa della Musica 2016, il 21 giugno Special Stage all’Istituto dei Tumori
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Special Stage all’INT in occasione della Festa della Musica 2016 Blocco «E» 7mo piano – Sala attesa Trapianto di Fegato Martedì 21 giugno 2016 – Ore 16:00 – 18:00 Fondazione IRCCS Istituto Nazionale dei Tumori Via G. Venezian, 1 – 20133 Milano from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UmUZNG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]
IJMS, Vol. 17, Pages 957: Aquaporins in Urinary Extracellular Vesicles (Exosomes)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs […]
IJMS, Vol. 17, Pages 960: Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, […]
IJMS, Vol. 17, Pages 938: Genome-Wide Discriminatory Information Patterns of Cytosine DNA Methylation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Cytosine DNA methylation (CDM) is a highly abundant, heritable but reversible chemical modification to the genome. Herein, a machine learning approach was applied to analyze the accumulation of epigenetic marks in methylomes of 152 ecotypes and 85 silencing mutants of Arabidopsis thaliana. In an information-thermodynamics framework, two measurements were used: (1) the amount of information […]
IJMS, Vol. 17, Pages 962: The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass. Microalgae are currently used as an important source of valuable natural biologically active molecules, such as carotenoids, chlorophyll, long-chain polyunsaturated fatty acids, phycobiliproteins, carotenoids and enzymes. Significant advances have been achieved in microalgae biotechnology over the last decade, and the use of microalgae as […]
Aspirin may increase survival after colon cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
It is well known that aspirin has analgesic and fever-reducing properties. However, this drug may also increase the likelihood of surviving colon cancer. Kjetil Taskén, professor at the Faculty of Medicine, is one of the authors of a study that has… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1XZ8TKv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
Innovative device allows 3-D imaging of the breast with less radiation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Preliminary tests have demonstrated that a new device may enable existing breast cancer imagers to provide up to six times better contrast of tumours in the breast, while maintaining the same or better image quality and halving the radiation dose to… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1USuobv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
Migration of a foreign object to the parapharyngeal space
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
: an unusual factitious disorder via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Case report Migration of a foreign object to the parapharyngeal space: an unusual factitious disorder ☆ Migração de objeto estranho para o espaço parafaríngeo: transtorno factício incomum ☆ Senol Comoglu, Necati Enver, Comert Sen, , Levent Aydemir Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology and […]
Diabetes mellitus als prognostischer Marker beim Oropharynx- und Larynxkarzinom
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Diabetes mellitus als prognostischer Marker beim Oropharynx- und Larynxkarzinom: Zusammenfassung Aktuelle experimentelle und klinische Studien weisen darauf hin, dass Diabetes mellitus (DM) einen bedeutenden Risikofaktor bei verschiedenen Krebserkrankungen darstellt und sowohl die Pathogenese und Prognose beeinflussen kann. Zusätzlich weisen Antidiabetika wie z. B. Metformin eine antitumorigene Wirkung auf. Bis heute ist allerdings über die Rolle des […]
Spironolactone-induced hypersensitivity in a patient with acne vulgaris
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Spironolactone-induced hypersensitivity in a patient with acne vulgaris: Bipin Mehta, Neha Iyer, CM Iyer Indian Journal of Drugs in Dermatology 2016 2(1):40-41 Sir,Spironolactone has been used for the treatment of acne vulgaris (AV) in women above 25 years with hormonal-pattern AV, defined clinically as primarily inflammatory papules, many deep-seated and tender that are located predominantly […]
Motivation in computer-assisted instruction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Motivation in computer-assisted instruction: Objectives/Hypothesis Computer-aided instruction (CAI) is defined as instruction in which computers play a central role as the means of information delivery and direct interaction with learners. Computer-aided instruction has become mainstream in medical school curricula. For example, a three-dimensional (3D) computer module of the larynx has been created to teach laryngeal […]
Laryngeal burn injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Development of an in vivo model of laryngeal burn injury: Objectives/Hypothesis Inhalation injury significantly increases morbidity and mortality in burn patients. Approximately one in five burn patients have acute injury to the larynx, trachea, and/or lungs—and as many as 70% have long-term laryngeal abnormalities. Although inhalation injury to the lung has been studied extensively, no […]
Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers: Conditions: Skull Base Chordoma; Vertebral Chordoma Interventions: Procedure: Surgery; Radiation: Protontherapy Sponsor: Institut Curie Improved local control of chordoma initially treated with surgery or not, thanks to adjuvant radiotherapy oriented by conventional […]
Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap: ABSTRACT Background The anterolateral thigh (ALT) free flap is one of the most commonly used donor sites in head and neck reconstruction, however, it is not typically considered when an osseous component is needed. Methods Soft […]
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor: Abstract Background Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in […]
Intraoperative Nerve Monitoring in Thyroid Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Intraoperative Nerve Monitoring in Thyroid Surgery: This cross-sectional analysis uses data from the State Inpatient Databases to examine the use of intraoperative nerve monitoring and its association with patient and surgeon characteristics among patients undergoing thyroidectomy in 3 different states. Importance Intraoperative nerve monitoring (IONM) is increasingly performed during thyroid surgery. Objective To examine the […]
Synovial Cell Sarcoma of the Head and Neck
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Synovial Cell Sarcoma of the Head and Neck: This analysis of SEER registry data examines factors associated with survival in patients with synovial cell sarcoma of the head and neck. Importance Synovial cell sarcoma of the head and neck (SCSHN) is a rare tumor associated with significant morbidity and mortality. The literature regarding these tumors […]
Higher Health Care Costs in Middle-aged Adults With Hearing Loss
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Higher Health Care Costs in Middle-aged US Adults With Hearing Loss: This study uses data from the Truven Health MarketScan database to compare the costs of health care for a matched cohort of privately insured, middle-aged individuals with and without a diagnosis of hearing loss. http://ift.tt/1Ou9fVV
Association Between Comorbidity and p16 in Oropharyngeal SCC
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Association Between Comorbidity and p16 in Oropharyngeal SCC: This cohort study examines comorbidity and survival among p16-positive and p16-negative patients with oropharyngeal squamous cell carcinoma. Importance Comorbidity affects the prognosis of patients with cancer through the direct effects of the comorbid illness and by influencing the patients’ ability to tolerate treatment and mount a host […]
Giant Cerebellar Lesion in a Patient With Purulent Ear Drainage
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Giant Cerebellar Lesion in a Patient With Purulent Ear Drainage: A woman who had undergone an emergency craniotomy for brain decompression had purulent discharge from her right ear; imaging detected middle ear, mastoid, and infralabyrinthine involvement and meningitis and a large cerebellar lesion. What is your diagnosis? http://ift.tt/1Ou8SL3
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma: This case series examines ERBB2 aberrations in tumor samples from patients with laryngeal and oral cavity squamous cell carcinoma. Importance ERBB2 (formerly HER2) is an important drug target in breast cancer, where anti-ERBB2 therapy has been shown to lead to improvements in disease recurrence and […]
Recurrent, Slow-Growing Retropharyngeal Lesion
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Recurrent, Slow-Growing Retropharyngeal Lesion: A woman with a history of a benign retropharyngeal mass reported return of her symptoms, including mouth breathing, snoring, nasal obstruction, Eustachian tube dysfunction, and transient upper extremity paraplegias; MRI revealed a complete recurrence and enlargement of the mass. What is your diagnosis? http://ift.tt/1Ou9GiX
Preventing Recreational Noise–Induced Hearing Loss
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Preventing Recreational Noise–Induced Hearing Loss: This randomized clinical trial assesses the effectiveness of earplugs in preventing temporary hearing loss immediately following loud music exposure. Importance The incidence of hearing loss has risen in past years. Attendance at music festivals and concerts may contribute to this increasing problem. Objective To assess the effectiveness of earplugs in […]
Patient-Reported Toxic Effects
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
—The Dawn of a New Era: The article by Falchook et al in this issue of JAMA Otolaryngology–Head & Neck Surgery demonstrates the importance of fully assessing the toxic effects experienced by patients during and after definitive chemoradiotherapy for locally advanced head and neck cancers. With a focus on patient outcomes, such as response and […]
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery: This study of patient records in the National Cancer Database examines the incidence of 30-day unplanned readmission for patients undergoing parotidectomy for treatment of parotid cancer. Importance Thirty-day unplanned readmissions are increasingly used as a measure of quality care. Objective To describe the incidence of and […]
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor: [image: cover.gif?v=1&s=bc422faf3e5e5686ac05f12f] Abstract Background Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl. Methods and Results A 16-year-old female patient presented with palatal swelling. Radiographic findings revealed a well-defined radioluc... περισσότερα »
Intraoperative Nerve Monitoring in Thyroid Surgery
Intraoperative Nerve Monitoring in Thyroid Surgery: This cross-sectional analysis uses data from the State Inpatient Databases to examine the use of intraoperative nerve monitoring and its association with patient and surgeon characteristics among patients undergoing thyroidectomy in 3 different states. Importance Intraoperative nerve monitoring (IONM) is increasingly performed during thyroid surgery. Objective To examine the use of IONM and its association with patient demographic characteristics and surgeon volume. Design, Setting, and Participants A cross-sectional a... περισσότερα »
Synovial Cell Sarcoma of the Head and Neck
Synovial Cell Sarcoma of the Head and Neck: This analysis of SEER registry data examines factors associated with survival in patients with synovial cell sarcoma of the head and neck. Importance Synovial cell sarcoma of the head and neck (SCSHN) is a rare tumor associated with significant morbidity and mortality. The literature regarding these tumors is limited to case series and case reports. We used data from the population-based US Surveillance, Epidemiology, and End Results (SEER) cancer registry to determine factors affecting both overall survival and disease-specific surv... περισσότερα »
Higher Health Care Costs in Middle-aged Adults With Hearing Loss
Higher Health Care Costs in Middle-aged US Adults With Hearing Loss: [image: old160002.pdf.gif] This study uses data from the Truven Health MarketScan database to compare the costs of health care for a matched cohort of privately insured, middle-aged individuals with and without a diagnosis of hearing loss.
Association Between Comorbidity and p16 in Oropharyngeal SCC
Association Between Comorbidity and p16 in Oropharyngeal SCC: This cohort study examines comorbidity and survival among p16-positive and p16-negative patients with oropharyngeal squamous cell carcinoma. Importance Comorbidity affects the prognosis of patients with cancer through the direct effects of the comorbid illness and by influencing the patients’ ability to tolerate treatment and mount a host response. However, the prognostic importance of comorbidity in oropharyngeal squamous cell carcinoma is not well characterized in the era of human papillomavirus infection. Obje... περισσότερα »
Giant Cerebellar Lesion in a Patient With Purulent Ear Drainage
Giant Cerebellar Lesion in a Patient With Purulent Ear Drainage: [image: s_ocg160002f1.png] A woman who had undergone an emergency craniotomy for brain decompression had purulent discharge from her right ear; imaging detected middle ear, mastoid, and infralabyrinthine involvement and meningitis and a large cerebellar lesion. What is your diagnosis? [image: First page PDF preview]
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma: This case series examines ERBB2 aberrations in tumor samples from patients with laryngeal and oral cavity squamous cell carcinoma. Importance ERBB2 (formerly HER2) is an important drug target in breast cancer, where anti-ERBB2 therapy has been shown to lead to improvements in disease recurrence and overall survival. ERBB2 status in head and neck squamous cell carcinoma (HNSCC) has not been well studied. Identification of ERBB2-positive tumors and characterization of response to ERBB2 therapy could lead to t... περισσότερα »
Recurrent, Slow-Growing Retropharyngeal Lesion
Recurrent, Slow-Growing Retropharyngeal Lesion: [image: s_ocg160010f1.png] A woman with a history of a benign retropharyngeal mass reported return of her symptoms, including mouth breathing, snoring, nasal obstruction, Eustachian tube dysfunction, and transient upper extremity paraplegias; MRI revealed a complete recurrence and enlargement of the mass. What is your diagnosis? [image: First page PDF preview]
Preventing Recreational Noise–Induced Hearing Loss
Preventing Recreational Noise–Induced Hearing Loss: This randomized clinical trial assesses the effectiveness of earplugs in preventing temporary hearing loss immediately following loud music exposure. Importance The incidence of hearing loss has risen in past years. Attendance at music festivals and concerts may contribute to this increasing problem. Objective To assess the effectiveness of earplugs in preventing temporary hearing loss immediately following music exposure. Design, Setting, and Participants A randomized, single-blind clinical trial was conducted on Sept... περισσότερα »
Patient-Reported Toxic Effects
—The Dawn of a New Era: [image: oic160004.pdf.gif] The article by Falchook et al in this issue of JAMA Otolaryngology–Head & Neck Surgery demonstrates the importance of fully assessing the toxic effects experienced by patients during and after definitive chemoradiotherapy for locally advanced head and neck cancers. With a focus on patient outcomes, such as response and survival, toxicity data may be underestimated in many clinical trials, which poses a concern for patients in the era of human papilloma virus (HPV)–related head and neck cancers. Because the long-term survival ra... περισσότερα »
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery: This study of patient records in the National Cancer Database examines the incidence of 30-day unplanned readmission for patients undergoing parotidectomy for treatment of parotid cancer. Importance Thirty-day unplanned readmissions are increasingly used as a measure of quality care. Objective To describe the incidence of and risk factors for 30-day unplanned readmissions for patients undergoing treatment for cancer of the parotid gland. Design, Setting, and Participants A retrospective cohort study was ... περισσότερα »
Parent Perception of Newborn Hearing Screening
Parent Perception of Newborn Hearing Screening: This cross-sectional study provides insight into parent recall of universal newborn hearing screening. Importance An unacceptably high number of children who do not pass universal newborn hearing screening (UNHS) are lost to follow-up. Objectives To provide insight into parent recall of UNHS. Design, Setting, and Participants In this nationally representative cross-sectional survey, 2144 US parent households were surveyed in May 2012 using the Knowledge Panel. Responses of parents whose children were born before vs after UN... περισσότερα »
Tracheoesophgeal Fistula Caused by a Button Battery Ingestion
[image: First page PDF preview]Tracheoesophgeal Fistula Caused by a Button Battery Ingestion: [image: s_olo160001f1.png] This report describes the case of an 18-month-old who ingested a button battery.
Academic Otolaryngology Practice
Documentation Improvement Program for Academic Otolaryngology Practice: This pre-post study identifies areas of deficiency in inpatient documentation and instructs health care professionals on how to improve the quality and accuracy of clinical records. Importance Physicians recognize the value of accurate documentation to facilitate patient care, communication, and the distribution of professional fees. However, the association between inpatient documentation, hospital billing, and quality metrics is less clear. Objectives To identify areas of deficiency in inpatient docum... περισσότερα »
Mass of the Anterior Nasal Septum
Mass of the Anterior Nasal Septum: [image: s_ocg150075f1.png] A man in 60s was seen for an incidental deep nasal septal mass that was discovered on a noncontrast head CT study; his only symptom was frontal and ethmoid sinus pressure, and imaging showed an expansile anterior nasal septum mass with internal matrix mineralization. What is your diagnosis? [image: First page PDF preview]
Methods of Recurrent Laryngeal Nerve Reconstruction
Methods of Recurrent Laryngeal Nerve Reconstruction: This canine model study compares conventional, revascularized, and bioengineered methods of recurrent laryngeal nerve reconstruction. Importance Damage to the recurrent laryngeal nerve (RLN) is highly detrimental to voice, swallow, and cough. The optimal method for reconstitution of a nerve gap after injury is unknown. Objective To evaluate multiple methods of RLN reconstruction. Design, Setting, and Participants This study used an established canine model of RLN injury to examine purpose-bred, conditioned, female, 20-... περισσότερα »
Toxic Effects of Chemoradiotherapy
Patient- vs Practitioner-Reported Toxic Effects of Chemoradiotherapy: This study examines the discrepancy between reports on toxic effects due to chemoradiotherapy for head and neck cancer by practitioners using the National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE) tool and by patients using the Patient-Reported Outcomes version of the CTCAE. *Importance* Agreement between patient- and practitioner-reported toxic effects during chemoradiotherapy for head and neck cancer is unknown. *Objective* To compare patient-reported symptom severity and p... περισσότερα »
An Expansile Petrous Apex Mass
An Expansile Petrous Apex Mass: [image: s_ocg160016f1.png] A girl had progressive, left-sided facial palsy with ipsilateral hearing loss and decreased facial sensation; CT showed a petrous apex expansile lesion involving the internal auditory canal, and MRI showed a well-circumscribed lesion extending into the fundus of the internal auditory canal. What is your diagnosis? [image: First page PDF preview]
Thyroid Cancer
Thyroid Cancer: [image: ovp160002.pdf.gif] This Viewpoint addresses the recommendations of the 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer with regard to the use of imaging modalities for the detection of thyroid cancer and known or suspected thyroid nodules.
Head and Neck Cancer
Scratching the Surface of Suicide in Head and Neck Cancer: [image: olr160002.pdf.gif] *In Reply* We would like to thank Drs Webb and Briscoe for their interest in our manuscript on the incidence of suicide in patients with head and neck cancer. The intent of the manuscript was not only to highlight the high rate of suicide in these patients, but to show that suicide rates were associated with the involved subsite in the head and neck. We postulated that the higher suicide rate among patients with laryngeal and hypopharyngeal malignant diseases, for example, may be related to the... περισσότερα »
Rapidly Enlarging Forehead Mass in a Young Retinoblastoma Survivor
Rapidly Enlarging Forehead Mass in a Young Retinoblastoma Survivor: [image: s_ocg150066f1.png] A young man with a lesion in the supraorbital region had been treated for bilateral retinoblastoma as an infant and had advanced malignant small blue cell tumor as a teenager; a surgical specimen showed multinucleated giant cells and bizarre stromal cells suggestive of treatment effect. What is your diagnosis? [image: First page PDF preview]
AR and NAR are diseases associated to anxiety and depression
Rhinitis as an associated factor for anxiety and depression amongst adults via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 16 June 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Martín Bedolla-Barajas, Jaime Morales-Romero, Norma Angélica Pulido-Guillén, Martín Robles-Figueroa, Brenda Renata Plascencia-Domínguez IntroductionAnxiety and depression are frequent disorders of chronic diseases, yet there is no conclusive information to their association with rhinitis.ObjectiveThe objective is to determine the frequ... περισσότερα »
Facial nerve paralysis as initial symptom of langerhans cell histiocytosis
*Case reportFacial nerve paralysis as initial symptom of langerhans cell histiocytosis Paralisia de nervo facial como sintoma inicial de histiocitose de célula de Langerhans ☆ ☆☆ - Onur Ismıa, , , - Rabia Bozdogan Arpacib, - Anıl Ozgurc, - Elvan Caglar Citakd, - Neslihan Etib, - Tugce Puturgelia, - Yusuf Vayisoglua* * - a Department of Otorhinolaryngology, Faculty of Medicine, University of Mersin, Turkey- b Department of Pathology, Faculty of Medicine, University of Mersin, Turkey- c Department of Radiology, Faculty of Medicine, University of Mersin, Turkey- d Department of ... περισσότερα »
Children with Down syndrome (DS) have a high incidence of middle ear disorders and congenital abnormalities of the external, middle and inner ear.
Wideband reflectance in Down syndrome via International Journal of Pediatric Otorhinolaryngology Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Jordana Costa Soares, Juliana Granja Urosas, Karenina Santos Calarga, Tathiany Silva Pichelli, Suelly Cecília Olivan Limongi, Navid Shahnaz, Renata Mota Mamede Carvallo ObjectiveChildren with Down syndrome (DS) have a high incidence of middle ear disorders and congenital abnormalities of the external, middle and inner ear. Energy reflectance (ER), a wideband acoustic immittanc... περισσότερα »
Concurrent chemoradiotherapy with cisplatin or cetuximab for locally advanced head and neck squamous cell carcinomas
Does human papilloma virus play a role?: [image: gr1.sml] The current standard of care for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) is concurrent chemoradiotherapy (CRT) [1]. The use of high-dose (100mg/m2 every 3weeks) cisplatin concurrent with radiotherapy (RT) is considered a standard CRT regimen [2]. However, CRT has been associated with frequent severe acute and late toxicities [3], and less toxic regimens have been investigated. Highlights - •Concurrent CRT was associated with better PFS over BRT independent of p16 status.... περισσότερα »
Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache
*Abstract* We appreciated the cost-effective analysis (CEA) by Malhotra et al of various diagnostic strategies for patients who present with thunderclap headache1. There is a variety of approaches that emergency assume in working up patients for potential aneurysmal subarachnoid hemorrhage (SAH), and a cost-effectiveness analysis (CEA) can encourage providers to pursue an efficient strategy. The authors analyze the effectiveness of three diagnostic approaches towards patients with thunderclap headache who have a negative head CT: observation, lumbar puncture (LP), or computed tomogr... περισσότερα »
Type I interferon promotes alveolar epithelial type II cell survival during pulmonary S. pneumoniae infection and sterile lung injury in mice
[image: cover.gif?v=1&s=7ed1ee29e575b52989bb5c85] Protecting the integrity of the lung epithelial barrier is essential to ensure respiration and proper oxygenation in patients suffering from various types of lung inflammation. Type I interferon (IFN-I) has been associated with pulmonary epithelial barrier function, however, the mechanisms and involved cell types remain unknown. We aimed to investigate the importance of IFN-I with respect to its epithelial barrier strengthening function to better understand immune-modulating effects in the lung with potential medical implications. ... περισσότερα »
Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.
*Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.* Int Forum Allergy Rhinol. 2016 Jun 16; Authors: Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA Abstract BACKGROUND: Sinonasal biofilms have been demonstrated in specimens collected from chronic rhinosinusitis (CRS) patients. Mounting evidence suggests that biofilms contribute to therapeutically recalcitrant CRS. Recently, the bitter taste receptor T2R38 has been implicated in the regulation of the sinona... περισσότερα »
Provocative testing of the esophagus and its future.
*Provocative testing of the esophagus and its future.* Ann N Y Acad Sci. 2016 Jun 16; Authors: Farmer AD, Franchina M, Gregersen H, Penagini R, Shaker A, Soffer E Abstract Standard tests in clinical practice commonly fail to demonstrate a clear esophageal etiology for symptoms such as heartburn, dysphagia, or chest pain. Over the years, various provocative measures have been developed to provide a better understanding of the origins of such symptoms. Some measures, such as esophageal acid infusion or changing bolus consistency, can be easily incorporated into clinical practice. Ot... περισσότερα »
Treatment of Malignant Esophageal Fistulas: Fluoroscopic Placement of Esophageal SEMS, Endoscopically-assisted through Surgical Gastrostomy. A Case Report.
*Treatment of Malignant Esophageal Fistulas: Fluoroscopic Placement of Esophageal SEMS, Endoscopically-assisted through Surgical Gastrostomy. A Case Report.* J Gastrointestin Liver Dis. 2016 Jun;25(2):249-52 Authors: Constantinescu G, Sandru V, Ilie M, Nedelcu C, Tincu R, Popa B Abstract Progressive esophageal carcinoma can infiltrate the surrounding tissues with subsequent development of a fistula, most commonly between the esophagus and the respiratory tract. The endoscopic placement of covered self-expanding metallic stents (SEMS) is the treatment of choice for malignant esoph... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.
*A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.* Dysphagia. 2016 Jun 15; Authors: Nimmons D, Michou E, Jones M, Pendleton N, Horan M, Hamdy S Abstract Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in... περισσότερα »
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
*Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.* Int J Clin Oncol. 2016 Jun 15; Authors: Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H Abstract BACKGROUND: Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcino... περισσότερα »
Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.* Am J Gastroenterol. 2016 Feb;111(2):295-6 Authors: Farré R PMID: 26882948 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1UD1KZ2
[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].* Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):260-4 Authors: Gao W, Hu F, Cheng H, Wang H, Yang Y, Liang H, Zhang S, Meng F, Cui M, Wei H, Sheng J, An HJ, Jiang B, Chen Y, Li Y, Zuo X, Gong J, Zhao P, Dong L, Wang B, Jiang K, Zhang G, Li J, Zhao Y, Gao H, Yang L Abstract OBJECTIVE: To observe the effects and safety of quadruple... περισσότερα »
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].
Related Articles *[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1406-8 Authors: Ren J, Zhao Y, Ren X Abstract Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In r... περισσότερα »
[Gastroesophageal reflux and otitis media with effusion].
Related Articles *[Gastroesophageal reflux and otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1315-8 Authors: Tian X, Liu Y, Liu H Abstract Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroes... περισσότερα »
[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].
Related Articles *[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1284-7 Authors: Li Z, Xu H, Hong Y, Shen W, Chen L Abstract OBJECTIVE: To explore the mechanism, clinical characterization, diagnosis and therapeutic approach of vocal process granuloma(VPG) induced by gastroesophageal reflux. METHOD: We performed a retrospective review of 4 cases. RESULT: In 4 male cases, 3 cases had no obvious symptoms of stomach and esophagus and 1 case had symptoms of bloat... περισσότερα »
[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].
Related Articles *[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1252-5 Authors: Luo H, Gao Y, Ma S, Yang Q, Shao N, Zhang A, Xu M Abstract OBJECTIVE: To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children. METHOD: Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which sho... περισσότερα »
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
Related Articles *[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001 Authors: Luo H, Ma S, Gao Y, Yan J, Hou J, Xu M Abstract OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to ... περισσότερα »
Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.
*Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.* Clin Neurol Neurosurg. 2016 May 31;147:71-77 Authors: Selikhova M, Tripoliti E, Fedoryshyn L, Matvienko Y, Stanetska H, Boychuk M, Komnatska I, Lees AJ, Sanotsky Y Abstract INTRODUCTION: In the last fifteen years a new cause of chronic manganese toxicity has been recognized. It follows recreational intravenous injections of Ephedrone, synthesized from a cold remedies contained pseudoephedrine. Potassium permanganate is used as an oxidant. It presents with severe parkinsonism-dys... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.
*A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.* Dysphagia. 2016 Jun 15; Authors: Nimmons D, Michou E, Jones M, Pendleton N, Horan M, Hamdy S Abstract Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in... περισσότερα »
Early diagnosis of oesophageal cancer improves outcomes.
Related Articles *Early diagnosis of oesophageal cancer improves outcomes.* Practitioner. 2016 Mar;260(1791):23-8, 3 Authors: Hopper AD, Campbell JA Abstract There are two main types of oesophageal cancer, oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC). They present in the same manner and both carry a five-year survival of only 16%. In the UK there is a 2:1 male to female ratio for oesophageal cancer. Peak incidence at presentation is in the 65-75 age group, with 95% of cases presenting in those over 50. Smoking is a major risk factor for both type... περισσότερα »
Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.* Am J Gastroenterol. 2016 Feb;111(2):295-6 Authors: Farré R PMID: 26882948 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1UD1KZ2
[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].* Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):260-4 Authors: Gao W, Hu F, Cheng H, Wang H, Yang Y, Liang H, Zhang S, Meng F, Cui M, Wei H, Sheng J, An HJ, Jiang B, Chen Y, Li Y, Zuo X, Gong J, Zhao P, Dong L, Wang B, Jiang K, Zhang G, Li J, Zhao Y, Gao H, Yang L Abstract OBJECTIVE: To observe the effects and safety of quadruple... περισσότερα »
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].
Related Articles *[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1406-8 Authors: Ren J, Zhao Y, Ren X Abstract Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In r... περισσότερα »
[Gastroesophageal reflux and otitis media with effusion].
Related Articles *[Gastroesophageal reflux and otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1315-8 Authors: Tian X, Liu Y, Liu H Abstract Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroes... περισσότερα »
[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].
Related Articles *[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1284-7 Authors: Li Z, Xu H, Hong Y, Shen W, Chen L Abstract OBJECTIVE: To explore the mechanism, clinical characterization, diagnosis and therapeutic approach of vocal process granuloma(VPG) induced by gastroesophageal reflux. METHOD: We performed a retrospective review of 4 cases. RESULT: In 4 male cases, 3 cases had no obvious symptoms of stomach and esophagus and 1 case had symptoms of bloat... περισσότερα »
[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].
Related Articles *[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1252-5 Authors: Luo H, Gao Y, Ma S, Yang Q, Shao N, Zhang A, Xu M Abstract OBJECTIVE: To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children. METHOD: Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which sho... περισσότερα »
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
Related Articles *[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001 Authors: Luo H, Ma S, Gao Y, Yan J, Hou J, Xu M Abstract OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to ... περισσότερα »
[Comparison between stapled and traditional suture closure total laryngectomy].
Related Articles *[Comparison between stapled and traditional suture closure total laryngectomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):963-6 Authors: Wang L, Wang W, Lou W Abstract OBJECTIVE: To compare the clinical results between stapled and traditional suture closure total laryngectomy. METHOD: Fifty-three cases of laryngeal cancer with total laryngectomy were divided into 2 groups: 32 cases with traditional suture closure total laryngectomy (group A) and 21 cases with stapled total laryngectomy group (group B). Compare two groups in pharyngeal fistu... περισσότερα »
Vestibular Paroxysmia, Superior Oblique Myokymia, and Ocular Neuromyotonia.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Therapy of Vestibular Paroxysmia, Superior Oblique Myokymia, and Ocular Neuromyotonia Curr Treat Options Neurol. 2016 Jul;18(7):34 Authors: Strupp M, Dieterich M, Brandt T, Feil K Abstract OPINION STATEMENT: Neurovascular compression syndromes are characterized by recurrent attacks of neurological symptoms and clinical signs depending on the cranial nerve affected. It is assumed that pulsatile compression of […]
Protective effect of peperphentonamine injection through the otocyst against gentamicin- induced cochlear damage
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
in guinea pigs].: Nan Fang Yi Ke Da Xue Xue Bao. 2016;36(4):557-61 Authors: Li BB, Wu J, Chen J, Chen H, Li YH Abstract OBJECTIVE: To explore the relationship of gentamicin-induced cochlear damage with autophagy-related protein LC3, beclin1, Na(+-)K(+-)2Cl(-) cotransporter (NKCC1) mRNA and endothelin-1 (ET-1), and investigate the protective mechanism of PPTA against gentamicin-induced cochlear […]
Nonsyndromic Sensorineural Hearing Loss.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Association of TMTC2 With JAMA Otolaryngol Head Neck Surg. 2016 Jun 16; Authors: Runge CL, Indap A, Zhou Y, Kent JW, King E, Erbe CB, Cole R, Littrell J, Merath K, James R, Rüschendorf F, Kerschner JE, Marth G, Hübner N, Göring HH, Friedland DR, Kwok WM, Olivier M Abstract Importance: Sensorineural hearing loss (SNHL) […]
A Pilot Randomized Controlled Trial of the Feasibility of a Multicomponent Delirium Prevention Intervention Versus Usual Care in Acute Stroke.
*A Pilot Randomized Controlled Trial of the Feasibility of a Multicomponent Delirium Prevention Intervention Versus Usual Care in Acute Stroke.* J Cardiovasc Nurs. 2016 Jun 15; Authors: Rice KL, Bennett MJ, Berger L, Jennings B, Eckhardt L, Fabré-LaCoste N, Houghton D, Vidal G, Gropen T, Diggs E, Barry E, St John J, Mathew S, Egger A, Ryan S, Egger R, Galarneau D, Gaines K, Ely EW Abstract BACKGROUND: Delirium after acute stroke is a serious complication. Numerous studies support a benefit of multicomponent interventions in minimizing delirium-related complications in at-risk pati... περισσότερα »
[The research of rehabilitation effect of cochlear implantation for deaf children with gene mutation].
Related Articles *[The research of rehabilitation effect of cochlear implantation for deaf children with gene mutation].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(13):1172-4 Authors: Kong Y, Liang S, Ren C, Liu X, Liu S Abstract OBJECTIVE: To assess the evaluation on auditory rehabilitation effect for 42 deaf children with GJB2 gene mutation after cochlear implantation to provide a reference for the cochlear implant effect evaluation of such patients. METHOD: To conduct the detection on common genetic deafness gene mutation hotspots of hearing impaired children ... περισσότερα »
Perception of Small Frequency Differences in Children with Auditory Processing Disorder or Specific Language Impairment.
*Perception of Small Frequency Differences in Children with Auditory Processing Disorder or Specific Language Impairment.* J Am Acad Audiol. 2016 Jun;27(6):489-497 Authors: Rota-Donahue C, Schwartz RG, Shafer V, Sussman ES Abstract BACKGROUND: Frequency discrimination is often impaired in children developing language atypically. However, findings in the detection of small frequency changes in these children are conflicting. Previous studies on children's auditory perceptual abilities usually involved establishing differential sensitivity thresholds in sample populations who were n... περισσότερα »
Rapid Serial Auditory Presentation: A New Measure of Statistical Learning in Speech Segmentation.
Related Articles *Rapid Serial Auditory Presentation: A New Measure of Statistical Learning in Speech Segmentation.* Exp Psychol. 2015;62(5):346-51 Authors: Franco A, Eberlen J, Destrebecqz A, Cleeremans A, Bertels J Abstract The Rapid Serial Visual Presentation procedure is a method widely used in visual perception research. In this paper we propose an adaptation of this method which can be used with auditory material and enables assessment of statistical learning in speech segmentation. Adult participants were exposed to an artificial speech stream composed of statistically defi... περισσότερα »
Factors Affecting Speech Discrimination in Children with Cochlear Implants: Evidence from Early-Implanted Infants.
*Factors Affecting Speech Discrimination in Children with Cochlear Implants: Evidence from Early-Implanted Infants.* J Am Acad Audiol. 2016 Jun;27(6):480-488 Authors: Phan J, Houston DM, Ruffin C, Ting J, Holt RF Abstract BACKGROUND: To learn words and acquire language, children must be able to discriminate and correctly perceive phonemes. Although there has been much research on the general language outcomes of children with cochlear implants (CIs), little is known about the development of speech perception with regard to specific speech processes, such as speech discrimination. ... περισσότερα »
The relationship between the Nasality Severity Index 2.0 and perceptual judgments of hypernasality.
*The relationship between the Nasality Severity Index 2.0 and perceptual judgments of hypernasality.* J Commun Disord. 2016 May 26;62:67-81 Authors: Bettens K, De Bodt M, Maryn Y, Luyten A, Wuyts FL, Van Lierde KM Abstract PURPOSE: The Nasality Severity Index 2.0 (NSI 2.0) forms a new, multiparametric approach in the identification of hypernasality. The present study aimed to investigate the correlation between the NSI 2.0 scores and the perceptual assessment of hypernasality. METHOD: Speech samples of 35 patients, representing a range of nasality from normal to severely hypernasa... περισσότερα »
Phonology in Swedish-speaking 3-year-olds born with unilateral cleft lip and palate treated with palatal closure in one or two stages.
*Phonology in Swedish-speaking 3-year-olds born with unilateral cleft lip and palate treated with palatal closure in one or two stages.* J Plast Surg Hand Surg. 2016 Jun 16;:1-6 Authors: Klintö K, Lohmander A Abstract BACKGROUND: Phonological disorders are common in 3-year-olds born with cleft palate compared to non-cleft peers. However, published results have been based on small samples. The purpose was to expand the knowledge on phonology of Swedish-speaking 3-year-olds with unilateral cleft lip and palate (UCLP), treated with primary palatal closure in one or two stages. METHOD... περισσότερα »
[The review of categorization features of tone perception].
Related Articles *[The review of categorization features of tone perception].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1396-400 Authors: Qi B, Liu B Abstract Categorical perception (CP) is the unique phenomenon that gradually morphed physical feature in a stimulus continuum tends to be perceived as discrete representations. CP has been evidenced in several modalities in the sensor perception. The first study of CP of phonetic perception was performed in 1957. However, the early CP studies focused on segmental features. The first study of CP of pitch contour... περισσότερα »
Speaker and Accent Variation Are Handled Differently: Evidence in Native and Non-Native Listeners.
*Speaker and Accent Variation Are Handled Differently: Evidence in Native and Non-Native Listeners.* PLoS One. 2016;11(6):e0156870 Authors: Kriengwatana B, Terry J, Chládková K, Escudero P Abstract Listeners are able to cope with between-speaker variability in speech that stems from anatomical sources (i.e. individual and sex differences in vocal tract size) and sociolinguistic sources (i.e. accents). We hypothesized that listeners adapt to these two types of variation differently because prior work indicates that adapting to speaker/sex variability may occur pre-lexically while ... περισσότερα »
Narrative Length and Speech Rate in Battered Women.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Narrative Length and Speech Rate in Battered Women.* PLoS One. 2015;10(11):e0142651 Authors: Fernández-Lansac V, Crespo M Abstract Narrative length and speech rate of traumatic recollections have been previously associated with different emotions and adjustment trajectories after trauma. However, the evidence is limited and the results are mixed. The present study aimed to evaluate length (i.e., word count) and speech rate (i.e., words per minute) in narratives of events with different v... περισσότερα »
Development of Auxiliaries in Young Children Learning African American English.
*Development of Auxiliaries in Young Children Learning African American English.* Lang Speech Hear Serv Sch. 2016 Jun 16;:1-16 Authors: Newkirk-Turner BL, Oetting JB, Stockman IJ Abstract Purpose: We examined language samples of young children learning African American English (AAE) to determine if and when their use of auxiliaries shows dialect-universal and dialect-specific effects. Method: The data were longitudinal language samples obtained from two children, ages 18 to 36 months, and three children, ages 33 to 51 months. Dialect-universal analyses examined age of first form a... περισσότερα »
[The effect of binaural bi-modal fitting on speech recognition of cochlear implant recipients with low frequency electrodes incompletely implanted].
Related Articles *[The effect of binaural bi-modal fitting on speech recognition of cochlear implant recipients with low frequency electrodes incompletely implanted].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):980-3 Authors: Xie Z, Wu P Abstract OBJECTIVE: To study the effect of binaural bi-modal fitting (one cochlear implant and a contralateral hearing aid) on speech recognition of cochlear implant recipients with low frequency electrodes incompletely implanted. METHOD: A total of 15 cochlear implant(CI) users who have low residual hearing (250 Hz 45-90 dBHL,... περισσότερα »
Deep Neural Networks with Multistate Activation Functions.
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Deep Neural Networks with Multistate Activation Functions.* Comput Intell Neurosci. 2015;2015:721367 Authors: Cai C, Xu Y, Ke D, Su K Abstract We propose multistate activation functions (MSAFs) for deep neural networks (DNNs). These MSAFs are new kinds of activation functions which are capable of representing more than two states, including the N-order MSAFs and the symmetrical MSAF. DNNs with these MSAFs can be trained via conventional Stochastic Gradient Descent (SGD) as wel... περισσότερα »
Predicting Achievable Fundamental Frequency Ranges in Vocalization Across Species.
*Predicting Achievable Fundamental Frequency Ranges in Vocalization Across Species.* PLoS Comput Biol. 2016 Jun;12(6):e1004907 Authors: Titze I, Riede T, Mau T Abstract Vocal folds are used as sound sources in various species, but it is unknown how vocal fold morphologies are optimized for different acoustic objectives. Here we identify two main variables affecting range of vocal fold vibration frequency, namely vocal fold elongation and tissue fiber stress. A simple vibrating string model is used to predict fundamental frequency ranges across species of different vocal fold size... περισσότερα »
Perceptions Toward Internet-Based Delivery of Hearing Aids among Older Hearing-Impaired Adults.
*Perceptions Toward Internet-Based Delivery of Hearing Aids among Older Hearing-Impaired Adults.* J Am Acad Audiol. 2016 Jun;27(6):441-457 Authors: Chandra N, Searchfield GD Abstract BACKGROUND: Despite evidence that hearing aids can improve the social and psychological functioning of older hearing-impaired adults, hearing aid uptake is low. High cost of hearing aids and poor access to audiology services in rural areas are potential barriers to hearing aid acquisition. Methods of hearing aid delivery deviating from the traditional clinician-based model have been available to cons... περισσότερα »
The relationship between the Nasality Severity Index 2.0 and perceptual judgments of hypernasality.
*The relationship between the Nasality Severity Index 2.0 and perceptual judgments of hypernasality.* J Commun Disord. 2016 May 26;62:67-81 Authors: Bettens K, De Bodt M, Maryn Y, Luyten A, Wuyts FL, Van Lierde KM Abstract PURPOSE: The Nasality Severity Index 2.0 (NSI 2.0) forms a new, multiparametric approach in the identification of hypernasality. The present study aimed to investigate the correlation between the NSI 2.0 scores and the perceptual assessment of hypernasality. METHOD: Speech samples of 35 patients, representing a range of nasality from normal to severely hypernasa... περισσότερα »
Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.
*Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.* Clin Neurol Neurosurg. 2016 May 31;147:71-77 Authors: Selikhova M, Tripoliti E, Fedoryshyn L, Matvienko Y, Stanetska H, Boychuk M, Komnatska I, Lees AJ, Sanotsky Y Abstract INTRODUCTION: In the last fifteen years a new cause of chronic manganese toxicity has been recognized. It follows recreational intravenous injections of Ephedrone, synthesized from a cold remedies contained pseudoephedrine. Potassium permanganate is used as an oxidant. It presents with severe parkinsonism-dys... περισσότερα »
Development of an in vivo model of laryngeal burn injury.
*Development of an in vivo model of laryngeal burn injury.* Laryngoscope. 2016 Jun 16; Authors: Dion GR, Teng S, Bing R, Hiwatashi N, Amin MR, Branski RC Abstract OBJECTIVES/HYPOTHESIS: Inhalation injury significantly increases morbidity and mortality in burn patients. Approximately one in five burn patients have acute injury to the larynx, trachea, and/or lungs-and as many as 70% have long-term laryngeal abnormalities. Although inhalation injury to the lung has been studied extensively, no models exist to study these insults to the larynx. As such, we developed an in vivo rabbit ... περισσότερα »
Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model
Epileptic seizures result from aberrant cellular and/or synaptic properties that can alter the capacity of neurons to integrate and relay information. During absence seizures, spike-and-wave discharges (SWDs) interfere with incoming sensory inputs and preclude conscious experience. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a well-established animal model of absence epilepsy, allows exploring the cellular basis of this impaired information processing. Here, by combining *in vivo* electrocorticographic and intracellular recordings from GAERS and control animals, we ... περισσότερα »
[Air-conducted ocular vestibular-evoked myogenic potential in patients with sudden sensorineural hearing loss].
Related Articles *[Air-conducted ocular vestibular-evoked myogenic potential in patients with sudden sensorineural hearing loss].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1243-7 Authors: Wang P, Luo W, Wu L, Chen Z, Lu X Abstract OBJECTIVE: To investigate the characteristics of air-conducted ocular vestibular-evoked myogenic potential(oVEMP) in patients with sudden sensorineural hearing loss (SSHL). So as to understanding the range and the degree of the vestibular system damage in patients with SSHL. METHOD: Thirty-five cases of unilateral SSHL were enrolled... περισσότερα »
Bovine Mammary Nutrigenomics and Changes in the Milk Composition due to Rapeseed or Sunflower Oil Supplementation of High-Forage or High-Concentrate Diets
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Background: Fatty acid (FA) composition plays a crucial role in milk nutritional quality. Despite the known nutritional regulation of ruminant milk composition, the overall mammary mechanisms underlying this regulation are far from being understood. The aim of our study was to determine nutritional regulation of mammary transcriptomes in relation to the cow milk composition. Methods: […]
Diagnostics, Vol. 6, Pages 24: Mobile Diagnostics Based on Motion? A Close Look at Motility Patterns in the Schistosome Life Cycle
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Imaging at high resolution and subsequent image analysis with modified mobile phones have the potential to solve problems related to microscopy-based diagnostics of parasitic infections in many endemic regions. Diagnostics using the computing power of “smartphones” is not restricted by limited expertise or limitations set by visual perception of a microscopist. Thus diagnostics currently almost […]
Diagnostics, Vol. 6, Pages 26: Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E(cRGDyK)2) in Induced Myocardial Infarction in Minipigs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Angiogenesis is part of the healing process following an ischemic injury and is vital for the post-ischemic repair of the myocardium. Therefore, it is of particular interest to be able to noninvasively monitor angiogenesis. This might, not only permit risk stratification of patients following myocardial infarction, but could also facilitate development and improvement of new […]
Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Abstract Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is an inhibitory receptor expressed on natural killer (NK) cells. In this study, we investigated the relationship between Siglec-7 expression and NK cell functions. Siglec-7 was highly expressed on NK cells and was preferentially expressed by mature NK cells from peripheral blood of healthy adults. Siglec-7+ NK cells […]
Association of low ficolin-lectin pathway parameters with Cardiac Syndrome X
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Summary In patients with typical angina pectoris, inducable myocardial ischaemia and macroscopically normal coronaries (Cardiac Syndrome X, CSX) significantly elevated plasma level of terminal complement complex (TCC), the common end-product of complement activation, has been observed without subsequent activation of the classical or the alternative pathways. Therefore, our aim was to clarify the role of […]
Hypothyroidism and pregnancy loss: Comparison with hyperthyroidism and diabetes in a Danish population-based study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Abstract Background Hypothyroidism is a common endocrine disease. The frequency of pregnancy loss in women with known hypothyroidism as opposed to women with a later diagnosis of hypothyroidism has not been evaluated and compared with other common endocrine diseases. Design Population-based cohort study using Danish nationwide registers. Participants All pregnancies in Denmark, 1997-2008, resulting in […]
Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache
*Abstract* We appreciated the cost-effective analysis (CEA) by Malhotra et al of various diagnostic strategies for patients who present with thunderclap headache1. There is a variety of approaches that emergency assume in working up patients for potential aneurysmal subarachnoid hemorrhage (SAH), and a cost-effectiveness analysis (CEA) can encourage providers to pursue an efficient strategy. The authors analyze the effectiveness of three diagnostic approaches towards patients with thunderclap headache who have a negative head CT: observation, lumbar puncture (LP), or computed tomogr... περισσότερα »
Response to “Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache”
Abstract We are grateful for the opportunity to expand the discussion and respond to the comments expressed. The purpose for the economic modelling in our study was not to calculate absolute costs and utilities, but to highlight the key factors involved in the decision-making process in managing patients with thunderclap headache, including the prevalence of SAH, sensitivity of noncontrast CT (which may vary depending on time of scan since onset) and the incidence of SAH caused by aneurysms. Management strategies may have to be tailored accordingly, and the knowledge of how these f... περισσότερα »
Potentially Missed Diagnosis of Ischemic Stroke in the Emergency Department in the Greater Cincinnati/Northern Kentucky Stroke Study
[image: cover.gif?v=1&s=28b3a020f5038a547166cee1] Abstract Objective Missed diagnoses of acute ischemic stroke (AIS) in the ED may result in lost opportunities to treat AIS. Our objectives were to describe the rate and clinical characteristics of missed AIS in the ED, to determine clinical predictors of missed AIS, and to report tissue plasminogen eligibility (tPA) among those with missed strokes. Methods Among a population of 1.3 million in a 5-county region of southwest Ohio and northern Kentucky, cases of AIS that presented to 16 EDs during 2010 were identified using ICD-9 code... περισσότερα »
Multicentre experience using daclatasvir and sofosbuvir to treat hepatitis C recurrence after liver transplantation - The CO23 ANRS CUPILT study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 45 δευτερόλεπτα
Journal of Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UCT98T via IFTTT
Factors influencing recurrence following initial hepatectomy for colorectal liver metastases
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 45 δευτερόλεπτα
British Journal of Surgery from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Yw27dS via IFTTT
Mortality trends in U.S. adults with septic shock, 2005-2011: A serial cross-sectional analysis of nationally-representative data
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 45 δευτερόλεπτα
BMC Infectious Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UCSEeT via IFTTT
The expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and its clinical indication.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Related Articles [The expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and its clinical indication]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(13):1152-5 Authors: Liu X, Shan C, Xu O, Wang J, Zhang H Abstract OBJECTIVE: The purpose of this study was to investigate the expression of […]
Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Related Articles Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma. Exp Mol Pathol. 2016 Feb;100(1):236-41 Authors: Zhu X, Luo Y, Bai Q, Lu Y, Lu Y, Wu L, Zhou X Abstract PURPOSE: To evaluate the clinical value of immunohistochemistry (IHC) using anti-BRAF V600E antibody (clone VE1) for specific […]
Severe and fatal pharmaceutical poisoning in young children in the UK
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective Accidental poisoning in young children is common, but severe or fatal events are rare. This study was performed to identify the number of such events occurring in the UK and the medications that were most commonly responsible. Design Analysis of national data sets containing information relating to severe and fatal poisoning in children in […]
The role of advocacy in promoting better child health
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Introduction Despite the many recent gains in child health, approximately six million children still die worldwide of mostly preventable causes. Mortality rates in the poorest countries are orders of magnitude higher than the richest and inequalities in health are also profound within the same country, as the richest groups across countries have similar health outcomes.1 […]
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor. Head Neck. 2016 Jun 16; Authors: Oh KY, Kang KR, Yoon HJ, Lee JI, Hong SP, Hong SD Abstract BACKGROUND: Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular […]
Rapid assessment of dietary calcium intake
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
A five-food item food frequency questionnaire (FFQ) and a 3-day food diary (3DFD) were used to estimate daily dietary calcium (Ca) intake in 32 patients aged 1–17 years. Median and IQR of Ca intake from 3DFD was 840 mg and 438 mg while from FFQ it was 700 mg and 987 mg, respectively. The non-parametrical […]
Progress and prospects in pharmacogenetics of antidepressant drugs.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Progress and prospects in pharmacogenetics of antidepressant drugs. Expert Opin Drug Metab Toxicol. 2016 Jun 16; Authors: Fabbri C, Crisafulli C, Calabrò M, Spina E, Serretti A Abstract INTRODUCTION: Depression is responsible for the most part of the personal and socio-economic burden due to psychiatric disorders. Since antidepressant response clusters in families, pharmacogenetics represents a […]
Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells. PLoS One. 2016;11(6):e0158022 Authors: Dotan I, Roche PJ, Tamilia M, Paliouras M, Mitmaker EJ, Trifiro MA Abstract [This corrects the article DOI: 10.1371/journal.pone.0149723.]. PMID: 27309538 [PubMed – as supplied by publisher] http://ift.tt/1Yw9XnL from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis […]
Outbreak of Zika virus disease in the Americas and the association with microcephaly, congenital malformations and Guillain-Barre syndrome
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Introduction Prior to 2007, Zika virus (ZIKV) was generally considered an arbovirus of limited importance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Now, a large, ongoing outbreak of ZIKV that started in Brazil in early 2015 is spreading rapidly across the Americas and has been potentially linked to congenital malformations […]
Diagnosis value of thyroid imaging reporting and data system in thyroid nodules.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Related Articles [Diagnosis value of thyroid imaging reporting and data system in thyroid nodules]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1264-7 Authors: Gao Q, Chen X, Hu X, Liu X, Zhao D Abstract OBJECTIVE: To explore the diagnostic value of the proposed thyroid imaging reporting and data system […]
Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap.
*Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap.* Head Neck. 2016 Jun 16; Authors: Brody RM, Pandey NC, Bur AM, O'Malley BW, Rassekh CH, Weinstein GS, Chalian AA, Newman JG, Cannady SB Abstract BACKGROUND: The anterolateral thigh (ALT) free flap is one of the most commonly used donor sites in head and neck reconstruction, however, it is not typically considered when an osseous component is needed. METHODS: Soft tissue harvests, cadaveric study, and retrospective analysis of a series ... περισσότερα »
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
*Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.* Head Neck. 2016 Jun 16; Authors: Oh KY, Kang KR, Yoon HJ, Lee JI, Hong SP, Hong SD Abstract BACKGROUND: Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl. METHODS AND RESULTS: A 16-year-old female patient presented with palatal swelling. Radiographic findi... περισσότερα »
Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells.
*Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells.* PLoS One. 2016;11(6):e0158022 Authors: Dotan I, Roche PJ, Tamilia M, Paliouras M, Mitmaker EJ, Trifiro MA Abstract [This corrects the article DOI: 10.1371/journal.pone.0149723.]. PMID: 27309538 [PubMed - as supplied by publisher] http://ift.tt/1Yw9XnL
Sorafenib and quinacrine target anti-apoptotic protein Mcl-1: a poor prognostic marker in anaplastic thyroid cancer (ATC).
*Sorafenib and quinacrine target anti-apoptotic protein Mcl-1: a poor prognostic marker in anaplastic thyroid cancer (ATC).* Clin Cancer Res. 2016 Jun 15; Authors: Abdulghani J, Gokare P, Gallant JN, Dicker DT, Whitcomb T, Cooper TK, Liao J, Derr J, Liu J, Goldenberg D, Finnberg NK, El-Deiry WS Abstract PURPOSE: Anaplastic thyroid cancer (ATC) comprises ~2% of all thyroid cancers and its median survival rate remains poor. It is responsible for more than one-third of thyroid cancer-related deaths. ATC is frequently resistant to conventional therapy and NFkappaB-signaling has been p... περισσότερα »
Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events.
*Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events.* Oncologist. 2016 Jun 15; Authors: González-Rodríguez E, Rodríguez-Abreu D, Spanish Group for Cancer Immuno-Biotherapy (GETICA) Abstract : In recent years, immune checkpoint inhibitors have emerged as effective therapies for advanced neoplasias. As new checkpoint target blockers become available and additional tumor locations tested, their use is expected to increase within a short time. Immune-related adverse events (irAEs) affecting the endocrine system are among the most frequent and complex tox... περισσότερα »
Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.
*Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.* Oncologist. 2016 Jun 15; Authors: Streff H, Profato J, Ye Y, Nebgen D, Peterson SK, Singletary C, Arun BK, Litton JK Abstract BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are associated with increased risk of breast, ovarian, and several other cancers. The purpose of the present study was to evaluate the incidence of cancer in first- and second-degree relatives of BRCA mutation carriers compared with the general population. MATERIALS AND METHODS: A total of 1,086 pedigrees of BRCA... περισσότερα »
Epigenetics in Medullary Thyroid Cancer: From Pathogenesis to Targeted Therapy.
*Epigenetics in Medullary Thyroid Cancer: From Pathogenesis to Targeted Therapy.* Recent Pat Anticancer Drug Discov. 2016 Jun 14; Authors: Vitale G, Dicitore A, Messina E, Sciammarella C, Faggiano A, Colao A Abstract BACKGROUND: Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyroid gland. Mutations of the RET proto-oncogene are implicated in the pathogenesis of MTC. Germline activating mutations of this gene have been reported in about 88-98 % of familial MTCs, while somatic mutations of RET gene have been detected in about 23-70 % of sporad... περισσότερα »
Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment - initial experience.
*Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment - initial experience.* Sci Rep. 2016;6:28081 Authors: Werner RA, Lückerath K, Schmid JS, Higuchi T, Kreissl MC, Grelle I, Reiners C, Buck AK, Lapa C Abstract Tyrosine kinase inhibitors (TKI) have shown clinical effectiveness in iodine-refractory differentiated thyroid cancer (DTC). The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet. 9 patients (3 female, 61 ± 8y) with progressive iodine-refractory DTC start... περισσότερα »
Effects and Role of Multikinase Inhibitors in Thyroid Cancer.
*Effects and Role of Multikinase Inhibitors in Thyroid Cancer.* Curr Pharm Des. 2016 Jun 13; Authors: Grimm D, Laursen R, Wehland M, Kopp S, Pietsch J, Infanger M, Grosse J Abstract BACKGROUND: Thyroid cancer is the most common type of endocrine neoplasia. Differentiated thyroid carcinoma (DTC) represents 94% of all thyroid cancer types. Approximately 20% experience local recurrence and 10% distant metastasis. The recurrent DTC often becomes less differentiated, loses the iodine uptake capability and consequently loses the radioactive iodine treatment option. Under these circumst... περισσότερα »
[The 3rd multidisciplinary meeting on thyroid cancer: April 29th 2015, Rambam Health Care Campus, Haifa, Israel].
*[The 3rd multidisciplinary meeting on thyroid cancer: April 29th 2015, Rambam Health Care Campus, Haifa, Israel].* Harefuah. 2016 Mar;155(3):191-3 Authors: Zolotov S, Joshua BZ, Mekel M, Hirsch Kolerman D, Yaish I, Ronen O, Robenshtok E, Fraenkel M, Weiler-Sagie M, Zidan J, Gil Z PMID: 27305758 [PubMed - in process] http://ift.tt/267bl2p
Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma.* Exp Mol Pathol. 2016 Feb;100(1):236-41 Authors: Zhu X, Luo Y, Bai Q, Lu Y, Lu Y, Wu L, Zhou X Abstract PURPOSE: To evaluate the clinical value of immunohistochemistry (IHC) using anti-BRAF V600E antibody (clone VE1) for specific detection of the BRAF V600E mutant protein in formalin-fixed paraffin-embedded papillary thyroid carcinoma (PTC) specimens. METHODS: A total of 118 PTC cases and 116 con... περισσότερα »
RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.* Exp Mol Pathol. 2016 Feb;100(1):151-9 Authors: Qiu J, Zhang W, Xia Q, Liu F, Li L, Zhao S, Gao X, Zang C, Ge R, Sun Y Abstract PURPOSE: The study aims to uncover molecular mechanisms of PTC (papillary thyroid carcinoma) progression and provide therapeutic biomarkers. METHODS: The paired tumor and control tissues were obtained from 5 PTC patients. RNA was extracted and cDNA libraries were constructed. RNA-sequencing (RNA-seq)... περισσότερα »
[Diagnosis value of thyroid imaging reporting and data system in thyroid nodules].
Related Articles *[Diagnosis value of thyroid imaging reporting and data system in thyroid nodules].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1264-7 Authors: Gao Q, Chen X, Hu X, Liu X, Zhao D Abstract OBJECTIVE: To explore the diagnostic value of the proposed thyroid imaging reporting and data system (TI-RADS) classification in thyroid nodules, and to investigate interobserver variability among different observers using TI-RADS classification for ultrasound. METHOD: We reviewed 667 thyroid nodules conventional ultrasound image data from 532 patients who we... περισσότερα »
[The effect of TFF3 on the proliferation and migration of papillary thyroid carcinoma K1 cell].
Related Articles *[The effect of TFF3 on the proliferation and migration of papillary thyroid carcinoma K1 cell].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(13):1194-8 Authors: Zheng X, Zhang T, Wu J, Zhang W, Zhang J, Wang B Abstract OBJECTIVE: To explore the effect on proliferation and invasion of human papillary thyroid carcinoma K1 cells by application of small hairpin RNA (shRNA) silencing TFF3 gene expression. METHOD: Using liposome transfection method, TFF3-shRNA targeting of TFF3 gene will be transient transfected to papillary thyroid carcinama K1 cells, ... περισσότερα »
[The expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and its clinical indication].
Related Articles *[The expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and its clinical indication].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(13):1152-5 Authors: Liu X, Shan C, Xu O, Wang J, Zhang H Abstract OBJECTIVE: The purpose of this study was to investigate the expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and to analyze their correlation in laryngeal squamous cell carcinoma. METHOD: Total 37 laryngeal carcinoma samples and para-carcinoma tissues were taken from the patients who accepted operation treatment in the Se... περισσότερα »
[The expression and clinical significance of EphA2 and E-cadherin in papillary thyroid carcinoma].
Related Articles *[The expression and clinical significance of EphA2 and E-cadherin in papillary thyroid carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):1020-3 Authors: Liu Y, Miao Y, Li X Abstract OBJECTIVE: To investigate the expression and clinical significance of EphA2 and E cadherin proteins in papillary thyroid carcinoma tissues, and to explore the relationship between them. METHOD: Using immunohistochemical SP/PV method, we detected the expression of EphA2 and E cadherin in tumors of 43 papillary thyroid carcinomas, 11 thyroid adenoma and 10 nor... περισσότερα »
Familial Central Hypothyroidism Caused by a Novel IGSF1 Gene Mutation.
*Familial Central Hypothyroidism Caused by a Novel IGSF1 Gene Mutation.* Thyroid. 2016 Jun 16; Authors: Rakover YT, Turgeon MO, London S, Hermanns P, Pohlenz J, Bernard DJ, Bercovich D Abstract BACKGROUND: Congenital hypothyroidism of central origin (CH-C) is a rare disease in which thyroid hormone deficiency is caused by insufficient thyrotropin stimulation of a normal thyroid gland. A recently described syndrome of isolated CH-C and macroorchidism was attributed to loss-of-function mutations of the immunoglobulin superfamily, member 1 gene (IGSF1). PATIENTS AND METHODS: CH-C wa... περισσότερα »
autophagy; +43 new citations
43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *autophagy* These pubmed results were generated on 2016/06/17 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. http://ift.tt/1YwefLU
Progress and prospects in pharmacogenetics of antidepressant drugs.
*Progress and prospects in pharmacogenetics of antidepressant drugs.* Expert Opin Drug Metab Toxicol. 2016 Jun 16; Authors: Fabbri C, Crisafulli C, Calabrò M, Spina E, Serretti A Abstract INTRODUCTION: Depression is responsible for the most part of the personal and socio-economic burden due to psychiatric disorders. Since antidepressant response clusters in families, pharmacogenetics represents a meaningful tool to provide tailored treatments and improve the prognosis of depression. AREAS COVERED: This review aims to summarize and discuss the pharmacogenetics of antidepressant dru... περισσότερα »
Opioids in the treatment of restless legs syndrome: pharmacological and clinical aspects.
*Opioids in the treatment of restless legs syndrome: pharmacological and clinical aspects.* Expert Opin Drug Metab Toxicol. 2016 Jun 16; Authors: de Biase S, Merlino G, Valente M, Gigli GL Abstract INTRODUCTION: Restless legs syndrome (RLS) is a common neurologic sensorimotor disorder that can have a negative impact on sleep, quality of life and health. In patients affected by severe RLS, pharmacological treatment is mandatory. AREAS COVERED: The present review is based on a search using PubMed from 1993 to 2016. It is focused on pharmacological and clinical aspects of opioids us... περισσότερα »
Comparison of cartilage graft and fascia in type 1 tympanoplasty: systematic review and meta-analysis.
*Comparison of cartilage graft and fascia in type 1 tympanoplasty: systematic review and meta-analysis.* Acta Otolaryngol. 2016 Jun 16;:1-6 Authors: Yang T, Wu X, Peng X, Zhang Y, Xie S, Sun H Abstract CONCLUSIONS: Tympanoplasty using cartilage grafts has a better graft take rate than that using temporalis fascia grafts. There are no significant differences between cartilage grafts and temporalis fascia grafts for hearing outcomes. Contrary to the sliced cartilage sub-group, full-thickness cartilage grafts generate better hearing outcomes than temporalis fascia grafts. OBJECTIVE:... περισσότερα »
Practice Patterns and Projections for the US Pediatric Otolaryngology Workforce.
*Practice Patterns and Projections for the US Pediatric Otolaryngology Workforce.* JAMA Otolaryngol Head Neck Surg. 2016 Jun 16; Authors: Bell JR, Ruch-Ross H, Hotaling AJ Abstract Importance: This study represents up-to-date information on the current status of and future projections for the pediatric otolaryngology workforce. Objective: To provide an update on the practice patterns of and projections for the US pediatric otolaryngology workforce. Design, Setting, and Participants: An online survey was sent to all 172 members of the American Academy of Pediatrics Section on Otola... περισσότερα »
Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
*Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.* Head Neck. 2016 Jun 16; Authors: Oh KY, Kang KR, Yoon HJ, Lee JI, Hong SP, Hong SD Abstract BACKGROUND: Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl. METHODS AND RESULTS: A 16-year-old female patient presented with palatal swelling. Radiographic findi... περισσότερα »
Shape from shading and optical flow used for 3-dimensional reconstruction of endoscope image.
*Shape from shading and optical flow used for 3-dimensional reconstruction of endoscope image.* Acta Otolaryngol. 2016 Jun 16;:1-3 Authors: Lei L, Li J, Liu M, Hu X, Zhou Y, Yang S Abstract CONCLUSION: The shape from shading and optical flow are implemented to three-dimensional (3D) reconstruction. OBJECTIVE: Solve the problem of 3D reconstruction in endoscope imaging. METHOD: One of the fundamental approaches in the domain of computer vision is shape from shading. This algorithm was proposed to obtain the shape of an object from a single intensity image. Because of the severe cond... περισσότερα »
A Nordic survey on the management of head and neck CUP.
*A Nordic survey on the management of head and neck CUP.* Acta Otolaryngol. 2016 Jun 16;:1-5 Authors: Farnebo L, Laurell G, Mäkitie A Abstract CONCLUSION: The management of Head and Neck Cancer of Unknown Primary (HNCUP) patients varies both between centres within and also between the Nordic countries. This study contributes to a continuing discussion of how to improve the accuracy of diagnosis and quality of treatment of HNCUP patients. OBJECTIVES: The initiative for this study was based on the lack of common guidelines for diagnostic procedures and for treatment of HNCUP patient... περισσότερα »
Factors Affecting Speech Discrimination in Children with Cochlear Implants: Evidence from Early-Implanted Infants.
*Factors Affecting Speech Discrimination in Children with Cochlear Implants: Evidence from Early-Implanted Infants.* J Am Acad Audiol. 2016 Jun;27(6):480-488 Authors: Phan J, Houston DM, Ruffin C, Ting J, Holt RF Abstract BACKGROUND: To learn words and acquire language, children must be able to discriminate and correctly perceive phonemes. Although there has been much research on the general language outcomes of children with cochlear implants (CIs), little is known about the development of speech perception with regard to specific speech processes, such as speech discrimination. ... περισσότερα »
Markers of Overall Nutritional Status and Incident Hearing Impairment in Community-Dwelling Older Japanese: The Kurabuchi Study.
*Markers of Overall Nutritional Status and Incident Hearing Impairment in Community-Dwelling Older Japanese: The Kurabuchi Study.* J Am Geriatr Soc. 2016 Jun 16; Authors: Michikawa T, Nakamura T, Imamura H, Mizutari K, Saito H, Takebayashi T, Nishiwaki Y Abstract OBJECTIVES: To examine the association between four markers of overall nutritional status (a serum biomarker (albumin) and three anthropometric indices (body mass index (BMI), midarm circumference (MAC), calf circumference (CC))) and incident hearing impairment in older Japanese adults. DESIGN: Community-based prospectiv... περισσότερα »
Health utility values for patients with recurrent acute rhinosinusitis undergoing endoscopic sinus surgery: a nested case control study.
*Health utility values for patients with recurrent acute rhinosinusitis undergoing endoscopic sinus surgery: a nested case control study.* Int Forum Allergy Rhinol. 2016 Jun 16; Authors: Steele TO, Mace JC, Dedhia R, Rudmik L, Smith TL, Alt JA Abstract BACKGROUND: Health utility scores quantify an individual's valuation of particular health states and are vital components of health economic studies and cost-effectiveness research. We sought to characterize health utility values for patients with recurrent acute rhinosinusitis (RARS) both before and after endoscopic sinus surgery (... περισσότερα »
Stapedotomy With Adipose Tissue Seal: Hearing Outcomes, Incidence of Sensorineural Hearing Loss, and Comparison to Alternative Techniques.
*Stapedotomy With Adipose Tissue Seal: Hearing Outcomes, Incidence of Sensorineural Hearing Loss, and Comparison to Alternative Techniques.* Otol Neurotol. 2016 Jun 16; Authors: Lin KF, Selesnick S Abstract OBJECTIVE: To evaluate hearing outcomes and incidence of sensorineural hearing loss (SNHL) after stapedotomy with adipose tissue seal, and to compare adipose tissue sealing with alternative techniques. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: Primary stapedotomy was performed in 179 patients using a KTP laser, microdrill, piston pros... περισσότερα »
Predicting Achievable Fundamental Frequency Ranges in Vocalization Across Species.
*Predicting Achievable Fundamental Frequency Ranges in Vocalization Across Species.* PLoS Comput Biol. 2016 Jun;12(6):e1004907 Authors: Titze I, Riede T, Mau T Abstract Vocal folds are used as sound sources in various species, but it is unknown how vocal fold morphologies are optimized for different acoustic objectives. Here we identify two main variables affecting range of vocal fold vibration frequency, namely vocal fold elongation and tissue fiber stress. A simple vibrating string model is used to predict fundamental frequency ranges across species of different vocal fold size... περισσότερα »
Perceptions of children and their parents about the pain experienced during their hospitalization and its impact on parents' quality of life.
*Perceptions of children and their parents about the pain experienced during their hospitalization and its impact on parents' quality of life.* Jpn J Clin Oncol. 2016 Jun 15; Authors: Matziou V, Vlachioti E, Megapanou E, Ntoumou A, Dionisakopoulou C, Dimitriou V, Tsoumakas K, Matziou T, Perdikaris P Abstract OBJECTIVE: The aim of the study was to assess pain levels and perceptions concerning pain by both children and their parents during hospitalization, as well as the impact of that pain upon parents' quality of life. METHODS: The sample of the study consisted of 92 pediatric canc... περισσότερα »
Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.
*Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.* Int Forum Allergy Rhinol. 2016 Jun 16; Authors: Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA Abstract BACKGROUND: Sinonasal biofilms have been demonstrated in specimens collected from chronic rhinosinusitis (CRS) patients. Mounting evidence suggests that biofilms contribute to therapeutically recalcitrant CRS. Recently, the bitter taste receptor T2R38 has been implicated in the regulation of the sinona... περισσότερα »
Suicide in patients with gastric cancer: a population-based study.
*Suicide in patients with gastric cancer: a population-based study.* Jpn J Clin Oncol. 2016 Jun 15; Authors: Sugawara A, Kunieda E Abstract OBJECTIVE: We conducted this study to examine the rate of suicide in patients with gastric cancer and to identify factors associated with increased risk of suicide using the Surveillance, Epidemiology, and End Results database. METHODS: The database was queried for patients who were diagnosed with gastric cancer from 1998 to 2011. The rate of suicide and standardized mortality ratio were calculated. Multivariable analyses were conducted to id... περισσότερα »
Small Cell Carcinoma of the Gall Bladder.
Related Articles *Small Cell Carcinoma of the Gall Bladder.* WMJ. 2016 Apr;115(2):96-9 Authors: Haid M, Gahju B, Schulz C, Sterner D, Falconer S Abstract Small cell carcinoma of the gall bladder (SCCGB) is a rare condition, with only 53 prior cases reported in the world literature when our case was first diagnosed. Our patient was found to have limited stage disease and was treated with sequential laparoscopic cholecystectomy, etoposide/carboplatin chemotherapy followed by consolidating loco-regional radiation therapy. She is alive and well without evidence of disease more than 1... περισσότερα »
Spinal tuberculosis with severe neurological symptoms as a complication of intravesical BCG therapy for carcinoma of the bladder.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Spinal tuberculosis with severe neurological symptoms as a complication of intravesical BCG therapy for carcinoma of the bladder.* Neurol Neurochir Pol. 2016;50(2):131-8 Authors: Białecki J, Nowak-Misiak M, Rąpała K, Marczyński W, Suchodolski G, Truszczyńska A Abstract INTRODUCTION: Non-invasive bladder cancer is effectively treated with intravesical BCG therapy. The administration of the BCG vaccine is to destroy the neoplastic lesion or prevent further recurrences. The activity of the vaccine involves boosting t... περισσότερα »
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.* Exp Mol Pathol. 2016 Feb;100(1):207-11 Authors: Peng Y, Cai J, Yue C, Qing X Abstract Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. Laboratory studies showed altered liver function and mild pancytopenia. Hepatitis a... περισσότερα »
Dynamic contrast-enhanced and diffusion-weighted MRI of estrogen receptor-positive invasive breast cancers: Associations between quantitative MR parameters and Ki-67 proliferation status
Purpose To explore the association between quantitative parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and Ki-67 proliferation status in patients with estrogen receptor (ER)-positive invasive breast cancer. Materials and Methods We retrospectively reviewed the records of 88 patients with ER-positive invasive breast cancer who underwent preoperative DCE-MRI and DWI on a 3T scanner. Perfusion parameters (Ktrans, Kep, and Ve) and apparent diffusion coefficients (ADCs) were recorded, and we correlated these dat... περισσότερα »
[Diagnosis and treatment of rare malignant tumors in external auditory canal].
Related Articles *[Diagnosis and treatment of rare malignant tumors in external auditory canal].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(16):1438-42 Authors: Wang F, Wu N, Hou Z, Liu J, Shen W, Han W, Yang S Abstract OBJECTIVE: To analyze the diagnosis, therapy and prognosis of the rare cases of malignant tumors in external auditory canal. METHOD: Eight cases of rare malignant tumors in external auditory canal were collected except squamous cell carcinoma and adenoid cystic carcinoma. The clinical manifestation, staging, surgical method, secondary treatment an... περισσότερα »
Decreasing expression of glucose-regulated protein GRP78/BiP as a significant prognostic predictor in patients with advanced laryngeal squamous cell carcinoma
[image: cover.gif?v=1&s=bc422faf3e5e5686ac05f12f] Abstract Background The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) is important in the endoplasmic reticulum stress, and is highly expressed in various human cancers. The clinical and pathological features of GRP78/BiP are unclear in patients with advanced laryngeal squamous cell carcinoma (SCC). The purpose of this study was to investigate the clinicopathological significance of GRP78/BiP as a prognostic marker for laryngeal SCC. Methods A total of 59 patients with advanced laryngeal SCC ... περισσότερα »
Plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions.* Exp Mol Pathol. 2016 Feb;100(1):79-81 Authors: Qing X, Enbom E, Qing A, French S, Cai J Abstract Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extra-oral sites, as well as in HIV-negative patients. Cardiac involvement by lymphoma is very rare. The most common primary cardiac lymphoma is diffuse larg... περισσότερα »
The use of fibrin and gelatin fixation to repair a kinked internal carotid artery in carotid endarterectomy.
*The use of fibrin and gelatin fixation to repair a kinked internal carotid artery in carotid endarterectomy.* Surg Neurol Int. 2016;7(Suppl 15):S434-6 Authors: Kubota H, Sanada Y, Tanikawa R, Kato A Abstract BACKGROUND: The kinking of the internal carotid artery (ICA) after final closure in carotid endarterectomy (CEA) is thought to be uncommon. When it occurs, it is mandatory to reconstruct ICA to preserve normal blood flow. We herein present a case in which a fixation technique was applied to repair an ICA that became kinked during CEA. CASE DESCRIPTION: A 68-year-old man prese... περισσότερα »
[Diagnosis and management of intraparotid facial nerve schwannoma].
Related Articles *[Diagnosis and management of intraparotid facial nerve schwannoma].* Hua Xi Kou Qiang Yi Xue Za Zhi. 2015 Aug;33(4):431-5 Authors: Liu Z, Zhang G Abstract Intraparotid facial nerve schwannoma (IFNS) is a rare benign tumor. The management of IFNS is very challenging because of the lack of appropriate methods for preoperative diagnosis, which is often conducted intraoperatively in most cases. This article reviewed the literature on IFNS recorded in PubMed from 1958 to 2014 and described in detail its clinical manifestations, diagnoses and differential diagnoses, an... περισσότερα »
[Rare parotid gland tumors: enhanced computed tomography and pathological correlation].
Related Articles *[Rare parotid gland tumors: enhanced computed tomography and pathological correlation].* Hua Xi Kou Qiang Yi Xue Za Zhi. 2015 Aug;33(4):414-8 Authors: Wen X, Shen J, Wu D, Shao H, Liu L, Xu C Abstract OBJECTIVE: To investigate the correlation between enhanced computed tomography (CT) findings and pathological results of rare parotid gland tumors, and improve diagnosis accuracy. METHODS: The enhanced CT manifestations of 22 cases with pathologically documented rare parotid gland tumors, which included 6 cases of basal cell tumor, 5 cases of myoepithelioma, 4 cases... περισσότερα »
A refractory arachnoid cyst presenting with tremor, expressive dysphasia, and cognitive decline.
*A refractory arachnoid cyst presenting with tremor, expressive dysphasia, and cognitive decline.* Surg Neurol Int. 2016;7(Suppl 15):S431-3 Authors: Zwagerman NT, Pardini J, Mousavi SH, Friedlander RM Abstract BACKGROUND: Arachnoid cysts are common incidental findings on intracranial imaging, although they are rarely symptomatic. CASE DESCRIPTION: We present a case of a 49 year-old woman with a recurrent left supraorbital arachnoid cyst who developed staring spells, expressive dysphasia, and tremor after cyst fenestration and cystoperitoneal shunting. Her symptoms resolved after r... περισσότερα »
Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer.* Exp Mol Pathol. 2016 Feb;100(1):39-44 Authors: May M, Mosto J, Vazquez PM, Gonzalez P, Rojas P, Gass H, Lanari C, Molinolo AA Abstract Mucinous carcinoma (MBC) is a rare subtype of breast cancer characterized by the production of variable amounts of mucin, with a prognosis better than that of non-mucinous carcinomas (NMBC). The aim of this project was to evaluate the expression of STAT-5, RUNX-2, and FGFR-2 in a cohort of MBC and compare it w... περισσότερα »
[Air-conducted ocular vestibular-evoked myogenic potential in patients with sudden sensorineural hearing loss].
Related Articles *[Air-conducted ocular vestibular-evoked myogenic potential in patients with sudden sensorineural hearing loss].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1243-7 Authors: Wang P, Luo W, Wu L, Chen Z, Lu X Abstract OBJECTIVE: To investigate the characteristics of air-conducted ocular vestibular-evoked myogenic potential(oVEMP) in patients with sudden sensorineural hearing loss (SSHL). So as to understanding the range and the degree of the vestibular system damage in patients with SSHL. METHOD: Thirty-five cases of unilateral SSHL were enrolled... περισσότερα »
Therapy of Vestibular Paroxysmia, Superior Oblique Myokymia, and Ocular Neuromyotonia.
*Therapy of Vestibular Paroxysmia, Superior Oblique Myokymia, and Ocular Neuromyotonia.* Curr Treat Options Neurol. 2016 Jul;18(7):34 Authors: Strupp M, Dieterich M, Brandt T, Feil K Abstract OPINION STATEMENT: Neurovascular compression syndromes are characterized by recurrent attacks of neurological symptoms and clinical signs depending on the cranial nerve affected. It is assumed that pulsatile compression of the nerve is caused mainly by an artery. The result is segmental demyelination of the transition zone or the central part of the cranial nerve, which is covered by oligode... περισσότερα »
Comprehensive handbook of pediatric audiology - second edition.
*Comprehensive handbook of pediatric audiology - second edition.* Int J Audiol. 2016 Jun 16;:1-2 Authors: Flynn T PMID: 27309404 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/23fMYhl
upper respiratory tract infection; +44 new citations
44 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/06/17 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1V0mJVI
Gene expression and antiviral activity of interleukin-35 in response to influenza A virus infection.
*Gene expression and antiviral activity of interleukin-35 in response to influenza A virus infection.* J Biol Chem. 2016 Jun 15; Authors: Wang L, Zhu S, Xu G, Feng J, Han T, Zhao F, She YL, Liu S, Ye L, Zhu Y Abstract Interleukin (IL)-35 is a newly described member of the IL-12 family. It has been reported to inhibit inflammation and autoimmune inflammatory disease, and can increase apoptotic sensitivity. Little is known about the role of IL-35 during viral infection. Herein, high levels of IL-35 were found in peripheral blood mononuclear cells and throat swabs from patients with... περισσότερα »
[An Elderly Patient with Metastatic Breast Cancer Who Developed Severe Adverse Events such as Stomatitis and Interstitial Pneumonia after Everolimus plus Exemestane Treatment].
*[An Elderly Patient with Metastatic Breast Cancer Who Developed Severe Adverse Events such as Stomatitis and Interstitial Pneumonia after Everolimus plus Exemestane Treatment].* Gan To Kagaku Ryoho. 2016 Jun;43(6):753-5 Authors: Sakiyama K, Yoshida T, Goto Y, Kimura M Abstract An 80-year-old woman was diagnosed with right breast cancer with clinical Stage IIIA 6 years previously. She underwent mastectomy and axillary lymph node dissection. The pathological diagnosis was invasive micropapillary carcinoma with lymph node involvement. Immunohistochemically, the tumor was positive f... περισσότερα »
Clinical Challenges Q&A. 18. Oral Ulceration. Diagnosis. Congenital agranulocytosis (Kostmann syndrome).
Related Articles *Clinical Challenges Q&A. 18. Oral Ulceration. Diagnosis. Congenital agranulocytosis (Kostmann syndrome).* Dent Update. 2016 Mar;43(2):194-5 Authors: Scully C, Malamos D PMID: 27188141 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1S8JMvD
Comparison of cartilage graft and fascia in type 1 tympanoplasty: systematic review and meta-analysis.
*Comparison of cartilage graft and fascia in type 1 tympanoplasty: systematic review and meta-analysis.* Acta Otolaryngol. 2016 Jun 16;:1-6 Authors: Yang T, Wu X, Peng X, Zhang Y, Xie S, Sun H Abstract CONCLUSIONS: Tympanoplasty using cartilage grafts has a better graft take rate than that using temporalis fascia grafts. There are no significant differences between cartilage grafts and temporalis fascia grafts for hearing outcomes. Contrary to the sliced cartilage sub-group, full-thickness cartilage grafts generate better hearing outcomes than temporalis fascia grafts. OBJECTIVE:... περισσότερα »
Shape from shading and optical flow used for 3-dimensional reconstruction of endoscope image.
*Shape from shading and optical flow used for 3-dimensional reconstruction of endoscope image.* Acta Otolaryngol. 2016 Jun 16;:1-3 Authors: Lei L, Li J, Liu M, Hu X, Zhou Y, Yang S Abstract CONCLUSION: The shape from shading and optical flow are implemented to three-dimensional (3D) reconstruction. OBJECTIVE: Solve the problem of 3D reconstruction in endoscope imaging. METHOD: One of the fundamental approaches in the domain of computer vision is shape from shading. This algorithm was proposed to obtain the shape of an object from a single intensity image. Because of the severe cond... περισσότερα »
A Nordic survey on the management of head and neck CUP.
*A Nordic survey on the management of head and neck CUP.* Acta Otolaryngol. 2016 Jun 16;:1-5 Authors: Farnebo L, Laurell G, Mäkitie A Abstract CONCLUSION: The management of Head and Neck Cancer of Unknown Primary (HNCUP) patients varies both between centres within and also between the Nordic countries. This study contributes to a continuing discussion of how to improve the accuracy of diagnosis and quality of treatment of HNCUP patients. OBJECTIVES: The initiative for this study was based on the lack of common guidelines for diagnostic procedures and for treatment of HNCUP patient... περισσότερα »
A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse.
*A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse.* Acta Otolaryngol. 2016 Jun 16;:1-10 Authors: Tsuda J, Sugahara K, Hori T, Kanagawa E, Takaki E, Fujimoto M, Nakai A, Yamashita H Abstract OBJECTIVES: This study used Tsumura Suzuki Obese Diabetes (TSOD) mice as a spontaneous type 2 diabetes model and Tsumura Suzuki Non-obesity (TSNO) mice as controls to investigate factors involved in the onset of hearing impairment. METHOD: Body weight, blood glucose levels, and auditory brainstem responses (... περισσότερα »
Older Adults' Engagement During an Intervention Involving Off-the-Shelf Videogame.
*Older Adults' Engagement During an Intervention Involving Off-the-Shelf Videogame.* Games Health J. 2016 Jun;5(3):151-156 Authors: Belchior P, Marsiske M, Leite WL, Yam A, Thomas K, Mann W Abstract OBJECTIVE: The overall goal of our current study was to examine older adults' experience of Flow (i.e., subjective engagement) during the course of a home-based cognitive training program. MATERIALS AND METHODS: In this study, participants took part in a home-based training program. They were randomized to one of the two training groups. One group played an off-the-shelf videogame (i.e... περισσότερα »
Decreasing insulin sensitivity in women induces alterations in LH pulsatility.
*Decreasing insulin sensitivity in women induces alterations in LH pulsatility.* J Clin Endocrinol Metab. 2016 Jun 16;:jc20161727 Authors: van Leckwyck M, Kong W, Burton KJ, Amati F, Vionnet N, Pralong FP Abstract CONTEXT: Obesity is associated with neuroendocrine reproductive alterations and decreased fertility. OBJECTIVE: To gain insight into the neuroendocrine mechanisms implicated in these alterations. DESIGN: The effects on pulsatile LH secretion of 28 days of hyper-caloric diet were studied in lean and regularly cycling female volunteers. ∽50% extra calories (3 g sucrose/kg ... περισσότερα »
Effects of titanium dioxide nanoparticles on human keratinocytes.
*Effects of titanium dioxide nanoparticles on human keratinocytes.* Drug Chem Toxicol. 2016 Jun 16;:1-11 Authors: Wright C, Iyer AK, Wang L, Wu N, Yakisich JS, Rojanasakul Y, Azad N Abstract Titanium dioxide (TiO2) is a ubiquitous whitening compound widely used in topical products such as sunscreens, lotions and facial creams. The damaging health effects of TiO2 inhalation has been widely studied in rats, mice and humans showing oxidative stress increase, DNA damage, cell death and inflammatory gene upregulation in lung and throat cells; however, the effects on skin cells from lon... περισσότερα »
Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic and cinnamic acid.
*Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic and cinnamic acid.* Drug Chem Toxicol. 2016 Jun 16;:1-8 Authors: Taner G, Özkan Vardar D, Aydin S, Aytaç Z, Başaran A, Başaran N Abstract Vanillic acid (VA) found in vanilla and cinnamic acid (CA) the precursor of flavonoids and found in cinnamon oil, are natural plant phenolic acids which are secondary aromatic plant products suggested to possess many physiological and pharmacological functions. In vitro and in vivo experiments have shown that phenolic acids exhibit powerful... περισσότερα »
In vitro DNA damage by Casiopeina II-gly in human blood cells.
*In vitro DNA damage by Casiopeina II-gly in human blood cells.* Drug Chem Toxicol. 2016 Jun 16;:1-7 Authors: Rodríguez-Mercado JJ, Florín-Ramírez D, Álvarez-Barrera L, Altamirano-Lozano MA Abstract A variety of metal ions have biological functions, and many researchers have not actively investigated copper compounds, based on the assumption that endogenous metals might be less toxic. In the present study, we used a dual fluorochrome method and a single cell gel electrophoresis (SCGE) assay at pH > 13 to evaluate the cell viability and DNA damage induced by a copper-based antineo... περισσότερα »
Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse.
*Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse.* Drug Chem Toxicol. 2016 Jun 16;:1-12 Authors: Roy S, Chaudhuri TK Abstract CONTEXT: Diplazium esculentum, a commonly consumed seasonal vegetable, has been reported to have some pathological effects in some animals. But, its effect on the male reproductive function has not yet been studied. OBJECTIVE: To investigate the effects of boiled D. esculentum (BDE), the form which human consumes, on male reproductive functions of Swiss albino mice. MATERIALS AND METHODS: Male (120 i... περισσότερα »
Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicity in vivo.
*Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicity in vivo.* Drug Chem Toxicol. 2016 Jun 16;:1-9 Authors: Ogundele OM, Wasiu Gbolahan B, Emmanuel Cobham A, Azeez Olakunle I, Abdulbasit A Abstract BACKGROUND: A major effect of cyanide toxicity (CN) and vascular occlusion (VO) is the production of reactive oxygen species (ROS) linked with a defective energy coupling process in the mitochondria. In CN, oxygen is present but its conversion is blocked in the mitochondria (Complex V). By contrast, in VO, oxidative stress is... περισσότερα »
Long-term results of ablation with low radioiodine activity in patients with papillary thyroid carcinoma and predictive value of postoperative nonstimulated thyroglobulin.
*Long-term results of ablation with low radioiodine activity in patients with papillary thyroid carcinoma and predictive value of postoperative nonstimulated thyroglobulin.* Nucl Med Commun. 2016 Jun 14; Authors: Rosario PW, Mourão GF, Calsolari MR Abstract AIM: This study evaluated the long-term results of ablation with low iodine-131 (131I) activity in patients with papillary thyroid carcinoma (PTC) with a lower risk of recurrence and who remained with nonstimulated thyroglobulin (Tg) of at least 0.3 ng/ml after total thyroidectomy. METHODS: This was a prospective study includin... περισσότερα »
[The research status of probiotic treatment of allergic rhinitis].
Related Articles *[The research status of probiotic treatment of allergic rhinitis].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1140-2 Authors: Qiao W, Feng K, Luo Q Abstract Allergic rhinitis is nasal mucosa of immediate hypersensitivity, and the current treatment is not satisfied. With the increasing incidence in recent years, we pay more attention on the effective treatments. There are some published studies indicate the benefit of probiotic for allergic rhinitis. Refer to the related literature in recent years, the paper will discuss probiotic species, sa... περισσότερα »
Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjögren's Syndrome.
Related Articles *Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjögren's Syndrome.* Isr Med Assoc J. 2016 Mar-Apr;18(3-4):150-3 Authors: Colafrancesco S, Perricone C, Shoenfeld Y Abstract Sjögren's syndrome (SS), a chronic systemic autoimmune inflammatory condition involving the exocrine glands, has been suggested to be part of the spectrum of the Autoimmune/ inflammatory Syndrome Induced by Adjuvants (ASIA). ASIA incorporates an umbrella of clinical conditions including siliconosis, macrophage myofasciitis syndrome, and post-vaccination phenomena that occur after th... περισσότερα »
Practice Patterns and Projections for the US Pediatric Otolaryngology Workforce.
*Practice Patterns and Projections for the US Pediatric Otolaryngology Workforce.* JAMA Otolaryngol Head Neck Surg. 2016 Jun 16; Authors: Bell JR, Ruch-Ross H, Hotaling AJ Abstract Importance: This study represents up-to-date information on the current status of and future projections for the pediatric otolaryngology workforce. Objective: To provide an update on the practice patterns of and projections for the US pediatric otolaryngology workforce. Design, Setting, and Participants: An online survey was sent to all 172 members of the American Academy of Pediatrics Section on Otola... περισσότερα »
JAMA Otolaryngology-Head & Neck Surgery.
*JAMA Otolaryngology-Head & Neck Surgery.* JAMA Otolaryngol Head Neck Surg. 2016 Jun 1;142(6):513 Authors: PMID: 27310423 [PubMed - as supplied by publisher] from #ENT via xlomafota13 on Inoreader http://ift.tt/21qc2R8 via IFTTT
Highlights.
*Highlights.* JAMA Otolaryngol Head Neck Surg. 2016 Jun 1;142(6):511 Authors: PMID: 27310422 [PubMed - as supplied by publisher] from #ENT via xlomafota13 on Inoreader http://ift.tt/1Qb2zfT via IFTTT
Recognition and Documentation of Strangulation Crimes: A Review.
*Recognition and Documentation of Strangulation Crimes: A Review.* JAMA Otolaryngol Head Neck Surg. 2016 Jun 16; Authors: Armstrong M, Strack GB Abstract Importance: Strangulation accounts for 10% of violent deaths in the United States and 15% to 20% of deaths associated with domestic violence. However, strangulation deaths represent only a small fraction of nonfatal strangulation assaults, which occur with daily frequency in medium to large US cities. Careful evaluation and documentation of strangulation injuries may identify life-threatening medical conditions, and may facilitat... περισσότερα »
Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals
from Glioma via xlomafota13 on Inoreader http://ift.tt/1UmFl53 http://ift.tt/1UmFl53 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Yw7ny5 via IFTTT
Multicentre experience using daclatasvir and sofosbuvir to treat hepatitis C recurrence after liver transplantation - The CO23 ANRS CUPILT study
Journal of Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UCT98T via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rt6DMF via IFTTT
Factors influencing recurrence following initial hepatectomy for colorectal liver metastases
British Journal of Surgery from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Yw27dS via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Yw4sW6 via IFTTT
Mortality trends in U.S. adults with septic shock, 2005-2011: A serial cross-sectional analysis of nationally-representative data
BMC Infectious Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UCSEeT via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rt7xIY via IFTTT
Long-term effects of a randomized, controlled, tailor-made weight-loss intervention in primary care on the health and lifestyle of overweight and obese women
American Journal of Clinical Nutrition from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Yw1uB0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Yw4du6 via IFTTT
Comparing characteristics of sporadic and outbreak-associated foodborne illnesses, united states, 2004-2011
Emerging Infectious Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UCSioK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rt6XLz via IFTTT
Statins associated with decreased risk of new onset inflammatory bowel disease
The American Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1V0aUyM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Yw40r1 via IFTTT
Antibiotics use pattern and appropriateness among children in the treatment of cough/cold and diarrhea
Value in Health from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/28JJVlm via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rt6Z65 via IFTTT
The autophagosomal snare protein syntaxin 17 is an essential factor for the hepatitis c virus life cycle
Journal of Virology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1V07JqP via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Yw4XiX via IFTTT
IJERPH, Vol. 13, Pages 602: Activated Persulfate Oxidation of Perfluorooctanoic Acid (PFOA) in Groundwater under Acidic Conditions
Perfluorooctanoic acid (PFOA) is an emerging contaminant of concern due to its toxicity for human health and ecosystems. However, successful degradation of PFOA in aqueous solutions with a cost-effective method remains a challenge, especially for groundwater. In this study, the degradation of PFOA using activated persulfate under mild conditions was investigated. The impact of different factors on persulfate activity, including pH, temperature (25 °C–50 °C), persulfate dosage and reaction time, was evaluated under different experimental conditions. Contrary to the traditional alkali... περισσότερα »
Genetics: Evading antitumour immunity
Nature Reviews Cancer. doi:10.1038/nrc.2016.65 Author: Bryony Jones from Cancer via xlomafota13 on Inoreader http://ift.tt/1QaIOoD via IFTTT http://ift.tt/1UCRFeK from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21q6TIG via IFTTT
Metastasis: Brain metastasis bridges the gap
Nature Reviews Cancer. doi:10.1038/nrc.2016.64 Author: Anna Dart from Cancer via xlomafota13 on Inoreader http://ift.tt/24Vl7Cb via IFTTT http://ift.tt/1UzI38P from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WQqV0y via IFTTT
Resistance to BRAF combination therapies in colon cancer
Although recent clinical trials of BRAF inhibitor combinations have demonstrated improved efficacy in BRAF mutant colorectal cancer, emergence of acquired resistance limits clinical benefit. Here, we undertook a comprehensive effort to define mechanisms underlying drug resistance with the goal of guiding development of therapeutic strategies to overcome this limitation. We generated a broad panel of BRAF mutant resistant cell line models across seven different clinically-relevant drug combinations. Combinatorial drug treatments were able to abrogate ERK1/2 phosphorylation in paren... περισσότερα »
GON4L is a new driver of cancer growth
In principle, the inhibition of candidate gain-of-function genes defined through genomic analyses of large patient cohorts offers an attractive therapeutic strategy. In this study, we focused on changes in expression of CD24, a well validated clinical biomarker of poor prognosis and a driver of tumor growth and metastasis, as a benchmark to assess functional relevance. Through this approach, we identified GON4L as a regulator of CD24 from screening a pooled shRNA library of 176 candidate gain-of-function genes. GON4L depletion reduced CD24 expression in human bladder cancer cells, ... περισσότερα »
FAT10 stabilizes eEF1A1 in a complex manner
FAT10 is the only ubiquitin-like protein that can directly target substrates for degradation by proteasomes, but it can also stabilize the expression of certain substrates by antagonizing ubiquitination, through mechanisms as yet uncharacterized. In this study, we show how FAT10 stabilizes the translation elongation factor eEF1A1 which contributes to cancer cell proliferation. FAT10 overexpression increased expression of eEF1A1 which was sufficient to promote proliferation of cancer cells. Mechanistic investigations revealed that FAT10 competed with ubiquitin (Ub) for binding to t... περισσότερα »
An oncogenic role for EZH2 in lung cancer [Research Articles]
As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly observed in human epithelial cancers, such as non-small cell lung carcinoma (NSCLC), yet definitive demonstration of malignant transformation by deregulated EZH2 remains elusive. Here, we demonstrate the causal role of EZH2 overexpression in NSCLC with new genetically-engineered mouse models of lung adenocarcinoma. Deregulated EZH2 silences normal developmental pathways leading to epigenetic transfo... περισσότερα »
Numb Gene Enhances Radiation Sensitivity of Nonsmall Cell Lung Cancer Stem Cells
Cancer Biotherapy & Radiopharmaceuticals Jun 2016, Vol. 31, No. 5: 180-188. from Cancer via xlomafota13 on Inoreader http://ift.tt/1W2DIvK via IFTTT http://ift.tt/1Pxu9y9 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21q60Qw via IFTTT
Radiolabeling of Extracellular Vesicles with 99mTc for Quantitative In Vivo Imaging Studies
Cancer Biotherapy & Radiopharmaceuticals Jun 2016, Vol. 31, No. 5: 168-173. from Cancer via xlomafota13 on Inoreader http://ift.tt/1US3nVz via IFTTT http://ift.tt/1Pxu7q1 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WQqZxa via IFTTT
Decreased Expression of miR-548c-3p in Osteosarcoma Contributes to Cell Proliferation Via Targeting ITGAV
Cancer Biotherapy & Radiopharmaceuticals Jun 2016, Vol. 31, No. 5: 153-158. from Cancer via xlomafota13 on Inoreader http://ift.tt/1W2EhWi via IFTTT http://ift.tt/1W2Rizm from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21q5kdL via IFTTT
Estimation of Recurrence Risk After Normal 18F-FDG PET/CT in Nonsmall-Cell Lung Cancer
Cancer Biotherapy & Radiopharmaceuticals Jun 2016, Vol. 31, No. 5: 174-179. from Cancer via xlomafota13 on Inoreader http://ift.tt/1US2Se4 via IFTTT http://ift.tt/1PxuuB9 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WQrabZ via IFTTT
Gene expression and antiviral activity of interleukin-35 in response to influenza A virus infection.
*Gene expression and antiviral activity of interleukin-35 in response to influenza A virus infection.* J Biol Chem. 2016 Jun 15; Authors: Wang L, Zhu S, Xu G, Feng J, Han T, Zhao F, She YL, Liu S, Ye L, Zhu Y Abstract Interleukin (IL)-35 is a newly described member of the IL-12 family. It has been reported to inhibit inflammation and autoimmune inflammatory disease, and can increase apoptotic sensitivity. Little is known about the role of IL-35 during viral infection. Herein, high levels of IL-35 were found in peripheral blood mononuclear cells and throat swabs from patients with... περισσότερα »
[An Elderly Patient with Metastatic Breast Cancer Who Developed Severe Adverse Events such as Stomatitis and Interstitial Pneumonia after Everolimus plus Exemestane Treatment].
*[An Elderly Patient with Metastatic Breast Cancer Who Developed Severe Adverse Events such as Stomatitis and Interstitial Pneumonia after Everolimus plus Exemestane Treatment].* Gan To Kagaku Ryoho. 2016 Jun;43(6):753-5 Authors: Sakiyama K, Yoshida T, Goto Y, Kimura M Abstract An 80-year-old woman was diagnosed with right breast cancer with clinical Stage IIIA 6 years previously. She underwent mastectomy and axillary lymph node dissection. The pathological diagnosis was invasive micropapillary carcinoma with lymph node involvement. Immunohistochemically, the tumor was positive f... περισσότερα »
Clinical Challenges Q&A. 18. Oral Ulceration. Diagnosis. Congenital agranulocytosis (Kostmann syndrome).
Related Articles *Clinical Challenges Q&A. 18. Oral Ulceration. Diagnosis. Congenital agranulocytosis (Kostmann syndrome).* Dent Update. 2016 Mar;43(2):194-5 Authors: Scully C, Malamos D PMID: 27188141 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1S8JMvD via IFTTT
Provocative testing of the esophagus and its future.
*Provocative testing of the esophagus and its future.* Ann N Y Acad Sci. 2016 Jun 16; Authors: Farmer AD, Franchina M, Gregersen H, Penagini R, Shaker A, Soffer E Abstract Standard tests in clinical practice commonly fail to demonstrate a clear esophageal etiology for symptoms such as heartburn, dysphagia, or chest pain. Over the years, various provocative measures have been developed to provide a better understanding of the origins of such symptoms. Some measures, such as esophageal acid infusion or changing bolus consistency, can be easily incorporated into clinical practice. Ot... περισσότερα »
Treatment of Malignant Esophageal Fistulas: Fluoroscopic Placement of Esophageal SEMS, Endoscopically-assisted through Surgical Gastrostomy. A Case Report.
*Treatment of Malignant Esophageal Fistulas: Fluoroscopic Placement of Esophageal SEMS, Endoscopically-assisted through Surgical Gastrostomy. A Case Report.* J Gastrointestin Liver Dis. 2016 Jun;25(2):249-52 Authors: Constantinescu G, Sandru V, Ilie M, Nedelcu C, Tincu R, Popa B Abstract Progressive esophageal carcinoma can infiltrate the surrounding tissues with subsequent development of a fistula, most commonly between the esophagus and the respiratory tract. The endoscopic placement of covered self-expanding metallic stents (SEMS) is the treatment of choice for malignant esoph... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.
*A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.* Dysphagia. 2016 Jun 15; Authors: Nimmons D, Michou E, Jones M, Pendleton N, Horan M, Hamdy S Abstract Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in... περισσότερα »
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
*Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.* Int J Clin Oncol. 2016 Jun 15; Authors: Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H Abstract BACKGROUND: Phase I study of weekly administration of low-dose docetaxel/cisplatin concurrent with conventionally fractionated radiotherapy for locally advanced head and neck squamous cell carcino... περισσότερα »
Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.* Am J Gastroenterol. 2016 Feb;111(2):295-6 Authors: Farré R PMID: 26882948 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1UD1KZ2 via IFTTT
[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].* Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):260-4 Authors: Gao W, Hu F, Cheng H, Wang H, Yang Y, Liang H, Zhang S, Meng F, Cui M, Wei H, Sheng J, An HJ, Jiang B, Chen Y, Li Y, Zuo X, Gong J, Zhao P, Dong L, Wang B, Jiang K, Zhang G, Li J, Zhao Y, Gao H, Yang L Abstract OBJECTIVE: To observe the effects and safety of quadrupl... περισσότερα »
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].
Related Articles *[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1406-8 Authors: Ren J, Zhao Y, Ren X Abstract Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In ... περισσότερα »
[Gastroesophageal reflux and otitis media with effusion].
Related Articles *[Gastroesophageal reflux and otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1315-8 Authors: Tian X, Liu Y, Liu H Abstract Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroe... περισσότερα »
[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].
Related Articles *[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1284-7 Authors: Li Z, Xu H, Hong Y, Shen W, Chen L Abstract OBJECTIVE: To explore the mechanism, clinical characterization, diagnosis and therapeutic approach of vocal process granuloma(VPG) induced by gastroesophageal reflux. METHOD: We performed a retrospective review of 4 cases. RESULT: In 4 male cases, 3 cases had no obvious symptoms of stomach and esophagus and 1 case had symptoms of bloa... περισσότερα »
[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].
Related Articles *[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1252-5 Authors: Luo H, Gao Y, Ma S, Yang Q, Shao N, Zhang A, Xu M Abstract OBJECTIVE: To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children. METHOD: Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which sh... περισσότερα »
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
Related Articles *[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001 Authors: Luo H, Ma S, Gao Y, Yan J, Hou J, Xu M Abstract OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to... περισσότερα »
Comprehensive handbook of pediatric audiology - second edition
10.1080/14992027.2016.1195020<br>Traci Flynn from #ENT via xlomafota13 on Inoreader http://ift.tt/1UD1sBH via IFTTT
Comprehensive handbook of pediatric audiology - second edition
10.1080/14992027.2016.1195020<br>Traci Flynn from #ENT via xlomafota13 on Inoreader http://ift.tt/1UD1sBH via IFTTT
Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.
*Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.* Clin Neurol Neurosurg. 2016 May 31;147:71-77 Authors: Selikhova M, Tripoliti E, Fedoryshyn L, Matvienko Y, Stanetska H, Boychuk M, Komnatska I, Lees AJ, Sanotsky Y Abstract INTRODUCTION: In the last fifteen years a new cause of chronic manganese toxicity has been recognized. It follows recreational intravenous injections of Ephedrone, synthesized from a cold remedies contained pseudoephedrine. Potassium permanganate is used as an oxidant. It presents with severe parkinsonism-dys... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.
*A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.* Dysphagia. 2016 Jun 15; Authors: Nimmons D, Michou E, Jones M, Pendleton N, Horan M, Hamdy S Abstract Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in... περισσότερα »
Early diagnosis of oesophageal cancer improves outcomes.
Related Articles *Early diagnosis of oesophageal cancer improves outcomes.* Practitioner. 2016 Mar;260(1791):23-8, 3 Authors: Hopper AD, Campbell JA Abstract There are two main types of oesophageal cancer, oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC). They present in the same manner and both carry a five-year survival of only 16%. In the UK there is a 2:1 male to female ratio for oesophageal cancer. Peak incidence at presentation is in the 65-75 age group, with 95% of cases presenting in those over 50. Smoking is a major risk factor for both typ... περισσότερα »
Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.* Am J Gastroenterol. 2016 Feb;111(2):295-6 Authors: Farré R PMID: 26882948 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1UD1KZ2 via IFTTT
[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].* Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):260-4 Authors: Gao W, Hu F, Cheng H, Wang H, Yang Y, Liang H, Zhang S, Meng F, Cui M, Wei H, Sheng J, An HJ, Jiang B, Chen Y, Li Y, Zuo X, Gong J, Zhao P, Dong L, Wang B, Jiang K, Zhang G, Li J, Zhao Y, Gao H, Yang L Abstract OBJECTIVE: To observe the effects and safety of quadrupl... περισσότερα »
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].
Related Articles *[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1406-8 Authors: Ren J, Zhao Y, Ren X Abstract Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In ... περισσότερα »
[Gastroesophageal reflux and otitis media with effusion].
Related Articles *[Gastroesophageal reflux and otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1315-8 Authors: Tian X, Liu Y, Liu H Abstract Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroe... περισσότερα »
[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].
Related Articles *[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1284-7 Authors: Li Z, Xu H, Hong Y, Shen W, Chen L Abstract OBJECTIVE: To explore the mechanism, clinical characterization, diagnosis and therapeutic approach of vocal process granuloma(VPG) induced by gastroesophageal reflux. METHOD: We performed a retrospective review of 4 cases. RESULT: In 4 male cases, 3 cases had no obvious symptoms of stomach and esophagus and 1 case had symptoms of bloa... περισσότερα »
[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].
Related Articles *[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1252-5 Authors: Luo H, Gao Y, Ma S, Yang Q, Shao N, Zhang A, Xu M Abstract OBJECTIVE: To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children. METHOD: Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which sh... περισσότερα »
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
Related Articles *[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001 Authors: Luo H, Ma S, Gao Y, Yan J, Hou J, Xu M Abstract OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to... περισσότερα »
[Comparison between stapled and traditional suture closure total laryngectomy].
Related Articles *[Comparison between stapled and traditional suture closure total laryngectomy].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):963-6 Authors: Wang L, Wang W, Lou W Abstract OBJECTIVE: To compare the clinical results between stapled and traditional suture closure total laryngectomy. METHOD: Fifty-three cases of laryngeal cancer with total laryngectomy were divided into 2 groups: 32 cases with traditional suture closure total laryngectomy (group A) and 21 cases with stapled total laryngectomy group (group B). Compare two groups in pharyngeal fist... περισσότερα »
Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.
*Analysis of a distinct speech disorder seen in chronic manganese toxicity following Ephedrone abuse.* Clin Neurol Neurosurg. 2016 May 31;147:71-77 Authors: Selikhova M, Tripoliti E, Fedoryshyn L, Matvienko Y, Stanetska H, Boychuk M, Komnatska I, Lees AJ, Sanotsky Y Abstract INTRODUCTION: In the last fifteen years a new cause of chronic manganese toxicity has been recognized. It follows recreational intravenous injections of Ephedrone, synthesized from a cold remedies contained pseudoephedrine. Potassium permanganate is used as an oxidant. It presents with severe parkinsonism-dys... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.
*A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population.* Dysphagia. 2016 Jun 15; Authors: Nimmons D, Michou E, Jones M, Pendleton N, Horan M, Hamdy S Abstract Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in... περισσότερα »
Early diagnosis of oesophageal cancer improves outcomes.
Related Articles *Early diagnosis of oesophageal cancer improves outcomes.* Practitioner. 2016 Mar;260(1791):23-8, 3 Authors: Hopper AD, Campbell JA Abstract There are two main types of oesophageal cancer, oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC). They present in the same manner and both carry a five-year survival of only 16%. In the UK there is a 2:1 male to female ratio for oesophageal cancer. Peak incidence at presentation is in the 65-75 age group, with 95% of cases presenting in those over 50. Smoking is a major risk factor for both typ... περισσότερα »
Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Evaluating the Esophageal Epithelial Integrity: More Complex than it Seems.* Am J Gastroenterol. 2016 Feb;111(2):295-6 Authors: Farré R PMID: 26882948 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1UD1KZ2 via IFTTT
[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Quadruple regimens using domestically manufactured drugs in gastritis and duodenal ulcer patients for Helicobacter pylori eradication: a perspective, multicenter, randomized controlled trial].* Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):260-4 Authors: Gao W, Hu F, Cheng H, Wang H, Yang Y, Liang H, Zhang S, Meng F, Cui M, Wei H, Sheng J, An HJ, Jiang B, Chen Y, Li Y, Zuo X, Gong J, Zhao P, Dong L, Wang B, Jiang K, Zhang G, Li J, Zhao Y, Gao H, Yang L Abstract OBJECTIVE: To observe the effects and safety of quadrupl... περισσότερα »
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].
Related Articles *[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1406-8 Authors: Ren J, Zhao Y, Ren X Abstract Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In ... περισσότερα »
[Gastroesophageal reflux and otitis media with effusion].
Related Articles *[Gastroesophageal reflux and otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1315-8 Authors: Tian X, Liu Y, Liu H Abstract Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroe... περισσότερα »
Leitlinienarbeit im Bereich Naturheilkunde und Komplementärmedizin – das Potenzial ist noch lange nicht erschöpft
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Forsch Komplementmed from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/2678wOW via IFTTT
Atmosphere, Vol. 7, Pages 84: Characterization of the Interannual Variability of Precipitation and Streamflow in Tensift and Ksob Basins (Morocco) and Links with the NAO
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of this study is to understand the inter-annual hydrological variability (precipitation and streamflow) in the basins of the High Atlas in Morocco and to determine how climate fluctuations (represented by the North Atlantic Oscillation (NAO) climate index) are expressed in the hydrological system. To reach this objective, time series of precipitation and streamflow […]
‘Ransomware’ cyberattack highlights vulnerability of universities
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Staff at Canadian university given little guidance on how to mitigate future problems. Nature News doi: 10.1038/nature.2016.20111 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21q8Wwv via IFTTT
Cancers, Vol. 8, Pages 57: Wnt Signaling in Renal Cell Carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers. Due to poor diagnosis, high resistance to the systemic therapies and the fact that most RCC cases occur sporadically, current research switched its focus on studying the molecular mechanisms underlying RCC. The aim is the discovery of new effective and less toxic anti-cancer drugs […]
Schizophrenia and the Other: A Phenomenological Approach to ‘Positive Withdrawal’
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Schizophrenia, in phenomenological psychopathology, is often described as a self disturbance and sometimes as a disturbance of the self-world relation. This study seeks to elaborate on these concepts by examining the significance of the Other in relation to these disturbances. Method: Levinas’ account of the ‘home’ will be employed to interpret the phenomenon of […]
The historical origins of the safe haven status of the Swiss franc
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OtXvCM via IFTTT
Impact of Advance Notice Periods on the Performance Persistence of Hedge Funds
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This paper examines the impact of the advance notice period on hedge fund performance persistence in investors’ portfolios. As investors in hedge funds face several trading restrictions related to the funds’ common investment terms and conditions, it is hypothesized that the advance notice period generates illiquidity for investors and impairs their ability to benefit from […]
[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].
Related Articles *[Diagnosis and treatment of vocal process granuloma induced by gastroesophageal reflux: four cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1284-7 Authors: Li Z, Xu H, Hong Y, Shen W, Chen L Abstract OBJECTIVE: To explore the mechanism, clinical characterization, diagnosis and therapeutic approach of vocal process granuloma(VPG) induced by gastroesophageal reflux. METHOD: We performed a retrospective review of 4 cases. RESULT: In 4 male cases, 3 cases had no obvious symptoms of stomach and esophagus and 1 case had symptoms of bloa... περισσότερα »
[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].
Related Articles *[The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jul;29(14):1252-5 Authors: Luo H, Gao Y, Ma S, Yang Q, Shao N, Zhang A, Xu M Abstract OBJECTIVE: To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children. METHOD: Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which sh... περισσότερα »
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
Related Articles *[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001 Authors: Luo H, Ma S, Gao Y, Yan J, Hou J, Xu M Abstract OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to... περισσότερα »
