Letter: histological assessment of disease activity in ulcerative colitis – the problem of score evaluation and validation
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Letter: smoking as a modifiable risk factor for a complicated course in Crohn's disease
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Letter: histological assessment of disease activity in ulcerative colitis – the problem of score evaluation and validation; authors' reply
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Review article: the practical management of acute severe ulcerative colitis
Summary Background Acute severe ulcerative colitis (ASUC) is a life-threatening condition for which optimal management strategies remain ill-defined. Aim To review the evidence regarding the natural history, diagnosis, monitoring and treatment of ASUC to inform an evidence-based approach to management. Methods Relevant articles addressing the management of ASUC were identified from a search of MEDLINE, the Cochrane Library and conference proceedings. Results Of ASUC, 31–35% is steroid-refractory. Infliximab and ciclosporin salvage therapies have improved patient outcomes in ran... περισσότερα »
Stereotactic radiofrequency thermocoagulation for giant hypothalamic hamartoma
Stereotactic radiofrequency thermocoagulation for giant hypothalamic hamartoma: Journal of Neurosurgery, Ahead of Print. OBJECTIVE The authors undertook this study to validate the feasibility and safety of stereotactic radiofrequency thermocoagulation (SRT) for the surgical treatment of giant hypothalamic hamartoma (HH). METHODS Of the 109 patients who underwent SRT for hypothalamic hamartoma (HH) at the authors' institution between 1997 and 2013, 16 patients (9 female, 7 male) had giant HHs (maximum diameter ≥ 30 mm). The clinical records of these 16 patients were retrospectively ... περισσότερα »
Preoperative external tissue expansion for complex cranial reconstructions
Preoperative external tissue expansion for complex cranial reconstructions: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Reconstruction of large solitary cranial defects after multiple craniotomies is challenging because scalp contraction generally requires more than simple subcutaneous undermining to ensure effective and cosmetically appealing closure. In plastic and reconstructive surgery, soft tissue expansion is considered the gold standard for reconstructing scalp defects; however, these techniques are not well known nor are they routinely practiced among neurosurgeons. ...περισσότερα »
Stenosis of the bilateral internal carotid arteries
Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Dysexecutive syndrome is common in patients with moyamoya disease (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the bilateral internal carotid arteries and progressive collateral revascularization, and MMD can be classified as ischemic or hemorrhagic according to the disease presentation and history. In this study, the authors aimed to determine which aspects of executive function are impaired in p...περισσότερα »
MR-guided laser-induced thermal therapy (MRgLITT) can be used to treat intracranial tumors, epilepsy, and chronic pain syndromes
Intracranial MR-guided laser-induced thermal therapy: single-center experience with the Visualase thermal therapy system: Journal of Neurosurgery, Ahead of Print. OBJECTIVE MR-guided laser-induced thermal therapy (MRgLITT) can be used to treat intracranial tumors, epilepsy, and chronic pain syndromes. Here, the authors report their single-center experience with 102 patients, the largest series to date in which the Visualase thermal therapy system was used. METHODS A retrospective analysis of all patients who underwent MRgLITT between 2010 and 2014 was performed. Pathologies include...περισσότερα »
Probabilistic machine learning for the evaluation of presurgical language dominance
Probabilistic machine learning for the evaluation of presurgical language dominance: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Providing a reliable assessment of language lateralization is an important task to be performed prior to neurosurgery in patients with epilepsy. Over the last decade, functional MRI (fMRI) has emerged as a useful noninvasive tool for language lateralization, supplementing or replacing traditional invasive methods. In standard practice, fMRI-based language lateralization is assessed qualitatively by visual inspection of fMRI maps at a specific chose... περισσότερα »
Temporal delays in trauma craniotomies
Temporal delays in trauma craniotomies: Journal of Neurosurgery, Ahead of Print. OBJECTIVE The Brain Trauma Foundation recommendation regarding the timing of surgical evacuation of epidural hematomas and subdural hematomas is to perform the procedure as soon as possible. Indeed, faster evacuation is associated with better outcome. However, to the authors' knowledge, no study has looked at where delays in intrahospital care occurred for patients suffering from traumatic intracranial mass lesions. The goals of this study were as follows: 1) to characterize the performance of a Level ...περισσότερα »
Binostril versus mononostril approaches in endoscopic transsphenoidal pituitary surgery: clinical evaluation and cadaver study
Binostril versus mononostril approaches in endoscopic transsphenoidal pituitary surgery: clinical evaluation and cadaver study: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Over the past 2 decades, endoscopy has become an integral part of the surgical repertoire for skull base procedures. The present clinical evaluation and cadaver study compare binostril and mononostril endoscopic transnasal approaches and the surgical techniques involved. METHODS Forty patients with pituitary adenomas were treated with either binostril or mononostril endoscopic surgery. Neurosurgical, endoc...περισσότερα »
The association of visceral adipose tissue and subcutaneous adipose tissue with metabolic risk factors in a large population of Chinese adults
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Abstract Objective Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults Methods This study was based on cross-sectional analysis of data from 1,449 adults […]
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
With great interest we have read the articles of Petersen et al. and Wiegell et al. concerning the development of erythema following daylight-activated photodynamic therapy (PDT). Recently, daylight-activated PDT (DL-PDT) has been introduced as an attractive alternative for conventional PDT (cPDT). This article is protected by copyright. All rights reserved. from #ORL-AlexandrosSfakianakis via simeraentaxei on […]
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver […]
Microcephaly
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Microcephaly: An abnormally small head due to failure of brain growth. Microcephaly is an ominous sign because it is almost always associated with developmental delay and mental retardation. Many factors can impair the growth of the brain, including intrauterine infections (such as rubella, cytomegalovirus, and toxoplasmosis), intrauterine chemical exposure (such as in fetal alcohol syndrome), […]
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
With great interest we have read the articles of Petersen et al. and Wiegell et al. concerning the development of erythema following daylight-activated photodynamic therapy (PDT). Recently, daylight-activated PDT (DL-PDT) has been introduced as an attractive alternative for conventional PDT (cPDT). This article is protected by copyright. All rights reserved. from #ORL-AlexandrosSfakianakis via ola Kala […]
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver […]
A profile of inactive information seekers on influenza prevention: a survey of health care workers in Central Kentucky
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Abstract Objective This study developed a profile of inactive information seekers by characterising how they are different from active seekers, identifying possible determinants of inactive seekers and understanding characteristics of frequently asked influenza-related questions. Methods A survey and follow-up interviews were conducted between December 2010 and January 2011. A total of 307 health care workers […]
Bernie Sanders supporters confident about primary – WMUR Manchester
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
WMUR Manchester Bernie Sanders supporters confident about primary WMUR Manchester «And what are you going to get when you’re 90 years old dealing with cancer or heart disease?» Sanders asked. «Not much! Needless to say that’s a pretty …. Unfortunately, Trump speaks with forked tongue. Lot’s of talk but extremely lacking in substance. Sent: Saturday, […]
Issue Cover (January 2016)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Cover image by Nico Angliker, Michael Burri, Mariana Zaichuk, Jean-Marc Fritschy and Markus A. Rüegg. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PFsLv0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the […]
In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging–based fiber tracking
In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging–based fiber tracking: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Preoperative determination of the facial nerve (FN) course is essential to preserving its function. Neither regular preoperative imaging examination nor intraoperative electrophysiological monitoring is able to determine the exact position of the FN. The diffusion tensor imaging–based fiber tracking (DTI-FT) technique has been widely used for the preoperative noninvasive visualization of the neural fascic... περισσότερα »
Malignant carotid body tumor presenting with myelopathy
Malignant carotid body tumor presenting with myelopathy: case report: Journal of Neurosurgery: Spine, Ahead of Print. Malignant carotid body tumors are rare, with spread of the tumor mostly noted in regional lymph nodes. Vertebral metastases are an exceedingly rare presentation, only reported in isolated case reports, and present a diagnostic and management challenge. A case of widespread vertebral metastasis, presenting with myelopathy, from a carotid body tumor is discussed in this paper, along with management strategies.
Models of thyroid cancer,Models of multiple endocrine neoplasia,Models of pituitary neoplasia
Mouse models of thyroid cancer: A 2015 update via http://rss.sciencedirect.com/publication/science/03037207 Publication date: 5 February 2016 *Source:*Molecular and Cellular Endocrinology, Volume 421 Author(s): Lawrence S. Kirschner, Zahida Qamri, Suresh Kari, Amruta Ashtekar Thyroid cancer is the most common endocrine neoplasm, and its rate is rising at an alarming pace. Thus, there is a compelling need to develop in vivo models which will not only enable the confirmation of the oncogenic potential of driver genes, but also point the way towards the development of new therapeutics. Ove...περισσότερα »
GATA factors in endocrine neoplasia
GATA factors in endocrine neoplasia via http://rss.sciencedirect.com/publication/science/03037207 Publication date: 5 February 2016 *Source:*Molecular and Cellular Endocrinology, Volume 421 Author(s): Marjut Pihlajoki, Anniina Färkkilä, Tea Soini, Markku Heikinheimo, David B. Wilson GATA transcription factors are structurally-related zinc finger proteins that recognize the consensus DNA sequence WGATAA (the GATA motif), an essential cis-acting element in the promoters and enhancers of many genes. These transcription factors regulate cell fate specification and differentiation in a wid...περισσότερα »
Hypothyroidism : Oral l -thyroxine liquid versus tablet
Oral l -thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study: AbstractNo consistent data are present in literature about the effectiveness of levothyroxine (l-T4) liquid formulation in patients without malabsorption. The aim of this study is to compare the effectiveness of l-T4 liquid formulation, with l-T4 tablets, in hypothyroid patients without malabsorption or drug interference. One hundred and fifty two patients were recruited. Patients were switched from the l-T4 therapy in tablets, to liquid l-T4 at the same dosage, 30 min... περισσότερα »
Optimal timing of neck dissection remains debated in the conservative management of patients with locoregionally advanced squamous cell carcinoma of the head and neck
Place du curage ganglionnaire avant radiothérapie exclusive dans la prise en charge des carcinomes épidermoïdes localement évolués des voies aérodigestives supérieures via Cancer/Radiothérapie Publication date: Available online 31 December 2015 *Source:*Cancer/Radiothérapie Author(s): A. Modesto, J. Sarini, A. Benlyazid, M. Ouali, A. Laprie, P. Graff, S. Vergez, E. Uro-Coste, I. Fauquet, J.-P. Delord, M. Rives IntroductionLa place du curage cervical dans la prise en charge conservatrice des carcinomes épidermoïdes localement évolués des voies aérodigestives supérieures demeure largemen...περισσότερα »
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma: Background: Aldehyde dehydrogenase-1 (ALDH1) has been shown to be a potential cancer stem cell marker in different types of cancer. However, the role of its expression in tumor cells and the microenvironment in different types of cancer is still controversial. Materials and… Continue reading Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma
Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer
Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer: Background: Relative survival (RS) for patients with laryngeal cancer in the US population has yet to be described. Additionally, survival of patients with laryngeal cancer has demonstrated socioeconomic and racial disparities which have not been previously examined through the lens of RS. Materials… Continue reading Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer
Metronomic Chemotherapy in Adults with Advanced Refractory Solid Tumors
METRO1: A Phase I Study of Metronomic Chemotherapy in Adults with Advanced Refractory Solid Tumors: Background: The present monocentric and prospective phase 1 study evaluated the safety of a metronomic chemotherapy in refractory tumors. Patients and Methods: Patients with advanced solid cancer refractory to standard therapy received a combination of low-dose vinorelbine, cyclophosphamide and interferon-alpha.… Continue reading Metronomic Chemotherapy in Adults with Advanced Refractory Solid Tumors
Ultraviolet Radiation Exposure and the Incidence of Oral, Pharyngeal and Cervical Cancer and Melanoma
Ultraviolet Radiation Exposure and the Incidence of Oral, Pharyngeal and Cervical Cancer and Melanoma: An Analysis of the SEER Data: Background: Based on the hypothesis that ultraviolet radiation (UVR) exposure can cause DNA damage that may activate dormant viruses such as human papilloma virus, a recent ecological study, which estimated state-level UVR exposure, reported positive… Continue reading Ultraviolet Radiation Exposure and the Incidence of Oral, Pharyngeal and Cervical Cancer and Melanoma
Using Epigenetic Therapy to Overcome Chemotherapy Resistance
Using Epigenetic Therapy to Overcome Chemotherapy Resistance: It has been known for decades that as cancer progresses, tumors develop genetic alterations, making them highly prone to developing resistance to therapies. Classically, it has been thought that these acquired genetic changes are fixed. This has led to the paradigm of moving from one cancer therapy to… Continue reading Using Epigenetic Therapy to Overcome Chemotherapy Resistance
Esophageal Cancer. Prevention, Diagnosis and Therapy
Esophageal Cancer. Prevention, Diagnosis and Therapy: Esophageal Cancer. Prevention, Diagnosis and Therapy. Edited by N.F. Saba, B. El-Rayes. 2015, pp 244, Eur 124.79, ISBN: 978-3-319-20067-5.Springer International Publishing, Cham, Switzerland. This book reviews the recent progress made in the prevention, diagnosis, and treatment of esophageal cancer. Epidemiology, molecular biology, pathology, staging, and prognosis are first discussed.… Continue reading Esophageal Cancer. Prevention, Diagnosis and Therapy
Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages
Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages: An increase in tumor-associated macrophages (TAMs) around the tumor microenvironment has been closely associated with a poor prognosis in patients with cancer, and M2 TAMs promote tumor growth and tumor metastasis by stimulating angiogenesis or lymphangiogenesis in… Continue reading Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Diffe...περισσότερα »
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma: A single intraperitoneal injection of 50 or 75 mg/kg N-methyl-N-nitrosourea in male Sprague-Dawley rats at 4 weeks of age, dose-dependently resulted in cutaneous epithelial cysts and tumors of pilosebaceous origin. Cysts were composed of epidermal cysts or mixed… Continue reading Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea
The association of visceral adipose tissue and subcutaneous adipose tissue with metabolic risk factors in a large population of Chinese adults
Abstract Objective Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults Methods This study was based on cross-sectional analysis of data from 1,449 adults… Continue reading The association of visceral adipose tissue and subcutaneous adipose tissue with metabolic risk factors in a large population of Chinese adults
Cardioprotective Drugs : Anticancer drug treatment, particularly with anthracyclines, is frequently associated with cardiotoxicity, an effect exacerbated by trastuzumab
Effects of Administered Cardioprotective Drugs on Treatment Response of Breast Cancer Cells: Background: Anticancer drug treatment, particularly with anthracyclines, is frequently associated with cardiotoxicity, an effect exacerbated by trastuzumab. Several compounds are in use clinically to attenuate the cardiac-damaging effects of chemotherapy drugs, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, the anti-diabetic drug metformin, and dexrazoxane.… Continue reading Cardioprotective Drugs : Anticancer drug treatment, particularly with anthracyclines, is fre... περισσότερα »
Selection of nodules for surgery diagnosed as Bethesda category III [atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category]
Risk factors associated with malignancy and with triage to surgery in thyroid nodules classified as Bethesda category III (AUS/FLUS) via European Journal of Surgical Oncology (EJSO) Publication date: January 2016 *Source:*European Journal of Surgical Oncology (EJSO), Volume 42, Issue 1 Author(s): B. Kuru, A. Atmaca, I.A. Tarim, M. Kefeli, K. Topgul, S. Yoruker, M. Elmali, M. Danaci BackgroundSelection of nodules for surgery diagnosed as Bethesda category III [atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category] is very important. We ai...περισσότερα »
Dissection of right paraesophageal lymph node metastasis in papillary thyroid carcinoma
Risk factors and indication for via European Journal of Surgical Oncology (EJSO) Publication date: January 2016 *Source:*European Journal of Surgical Oncology (EJSO), Volume 42, Issue 1 Author(s): Lei Zhang, Hongfeng Liu, Yong Xie, Yu Xia, Bo Zhang, Guangliang Shan, Xiaoyi Li BackgroundRight paraesophageal lymph nodes (RPELNs) are located behind right recurrent laryngeal nerve which often ignored in central compartment lymph nodes (LNs) dissection of papillary thyroid carcinoma (PTC) patients. The aim of this study was to identify the risk factors for RPELN metastasis and indications...περισσότερα »
Esophageal cancer
Esophageal cancer From Wikipedia, the free encyclopedia Esophageal cancer[image: Diagram showing oesophageal cancer that has spread (M staging) CRUK 175.svg] Diagram showing esophageal cancer in an advanced stage with spread to the liver Classification and external resourcesSpecialtyOncology, general surgeryICD- 10C15ICD-9-CM150OMIM133239DiseasesDB9150MedlinePlus000283eMedicine article/277930 article/368206MeSHD004938 *Esophageal cancer* (or *oesophageal cancer*) is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach.[1] *Symptoms often include ... περισσότερα »
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma: Background: Aldehyde dehydrogenase-1 (ALDH1) has been shown to be a potential cancer stem cell marker in different types of cancer. However, the role of its expression in tumor cells and the microenvironment in different types of cancer is still controversial. Materials and Methods: ALDH1 protein was immunohistochemically investigated and analyzed in 157 samples of surgically dissected esophageal squamous cell carcinoma (ESCC) tissues. Results: ALDH1 protein expres... περισσότερα »
Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer
Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer: Background: Relative survival (RS) for patients with laryngeal cancer in the US population has yet to be described. Additionally, survival of patients with laryngeal cancer has demonstrated socioeconomic and racial disparities which have not been previously examined through the lens of RS. Materials and Methods: Data on 58,814 patients with laryngeal cancer were obtained from the National Cancer Database. Patients were diagnosed between 1998 and 2006, and had at least 5 years of follow-up. Birth-, year-,... περισσότερα »
Metronomic Chemotherapy in Adults with Advanced Refractory Solid Tumors
METRO1: A Phase I Study of Metronomic Chemotherapy in Adults with Advanced Refractory Solid Tumors: Background: The present monocentric and prospective phase 1 study evaluated the safety of a metronomic chemotherapy in refractory tumors. Patients and Methods: Patients with advanced solid cancer refractory to standard therapy received a combination of low-dose vinorelbine, cyclophosphamide and interferon-alpha. A dose escalation model with 3 levels was planned. The primary end-point was safety and tolerability, secondary end-points were treatment continuation rate at 4 months, progr...περισσότερα »
Ultraviolet Radiation Exposure and the Incidence of Oral, Pharyngeal and Cervical Cancer and Melanoma
Ultraviolet Radiation Exposure and the Incidence of Oral, Pharyngeal and Cervical Cancer and Melanoma: An Analysis of the SEER Data: Background: Based on the hypothesis that ultraviolet radiation (UVR) exposure can cause DNA damage that may activate dormant viruses such as human papilloma virus, a recent ecological study, which estimated state-level UVR exposure, reported positive correlations between annual UVR exposure and the incidence of oral, pharyngeal, and cervical cancer in 16 U.S. states using the International Agency for Research on Cancer (IARC) data. The purpose of the ...περισσότερα »
Using Epigenetic Therapy to Overcome Chemotherapy Resistance
Using Epigenetic Therapy to Overcome Chemotherapy Resistance: It has been known for decades that as cancer progresses, tumors develop genetic alterations, making them highly prone to developing resistance to therapies. Classically, it has been thought that these acquired genetic changes are fixed. This has led to the paradigm of moving from one cancer therapy to the next while avoiding past therapies. However, emerging data on epigenetic changes during tumor progression and use of epigenetic therapies have shown that epigenetic modifications leading to chemotherapy resistance have ...περισσότερα »
Esophageal Cancer. Prevention, Diagnosis and Therapy
Esophageal Cancer. Prevention, Diagnosis and Therapy: Esophageal Cancer. Prevention, Diagnosis and Therapy. *Edited by* N.F. Saba , B. El-Rayes. 2015, pp 244, Eur 124.79, ISBN: 978-3-319-20067-5.Springer International Publishing, Cham, Switzerland. This book reviews the recent progress made in the prevention, diagnosis, and treatment of esophageal cancer. Epidemiology, molecular biology, pathology, staging, and prognosis are first discussed. The radiologic assessment of esophageal cancer and the role of endoscopy in diagnosis, staging, and management are then described. The princip...περισσότερα »
Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages
Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages: An increase in tumor-associated macrophages (TAMs) around the tumor microenvironment has been closely associated with a poor prognosis in patients with cancer, and M2 TAMs promote tumor growth and tumor metastasis by stimulating angiogenesis or lymphangiogenesis in tumors. We herein examined the effects of nine synthetic hydroxystilbenes on M2 macrophage activation and differentiation, and three selected dihyd... περισσότερα »
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma: A single intraperitoneal injection of 50 or 75 mg/kg N-methyl-N-nitrosourea in male Sprague-Dawley rats at 4 weeks of age, dose-dependently resulted in cutaneous epithelial cysts and tumors of pilosebaceous origin. Cysts were composed of epidermal cysts or mixed epidermal and inner root sheath hybrid cysts. The majority of induced tumors were keratoacanthomas. A few tumors were trichofolliculomas, trichoblastomas, pilomatricomas, or sebaceous...περισσότερα »
Cardioprotective Drugs : Anticancer drug treatment, particularly with anthracyclines, is frequently associated with cardiotoxicity, an effect exacerbated by trastuzumab
Effects of Administered Cardioprotective Drugs on Treatment Response of Breast Cancer Cells: Background: Anticancer drug treatment, particularly with anthracyclines, is frequently associated with cardiotoxicity, an effect exacerbated by trastuzumab. Several compounds are in use clinically to attenuate the cardiac-damaging effects of chemotherapy drugs, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, the anti-diabetic drug metformin, and dexrazoxane. However, there is concern that the cardiac-preserving mechanisms of these drugs may also limit the anticance...περισσότερα »
LPA Increases Tumor Growth and Bone Destruction Through Enhancement of Osteoclastogenic Cytokines
LPA Increases Tumor Growth and Bone Destruction Through Enhancement of Osteoclastogenic Cytokines: Background: Lysophosphatidic acid (LPA) production in osteoblasts has multiple effects on osteoclast formation and function and raises the possibility that LPA may serve as a signaling molecule for the reciprocal conversation of both osteoblasts and osteoclasts within the tumor–bone microenvironment for bone resorption. However, little is known on the effect of LPA in regulating the function of both cancer cells and osteoclasts in the bone microenvironment. Materials and Methods: PC-3...περισσότερα »
18F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes
Implication of 18F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases with Breast Cancer: In order to evaluate affected axillary lymph nodes in breast cancer by positron-emission tomography using 18F-fluorodeoxyglucose (FDG-PET), an understanding of FDG avidity is important. In the present study, we examined whether certain factors, including lymphatic spread and size of metastatic lymph nodes, were associated with FDG avidity in order to evaluate the benefits of a FDG-PET assessment of axillary node metastases. We retrospectively investigated the cases of 179 cons...περισσότερα »
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells: Background: The survival rate of patients with head and neck squamous cell carcinoma (HNSCC) stands at approximately 50% and this has not improved in decades. This study developed a novel sirtuin-3 (SIRT3) inhibitor (LC-0296) and examined its role in altering HNSCC tumorigenesis. Materials and Methods: The effect of the SIRT3 inhibitor, LC-0296, on cell survival, proliferation, and apoptosis, and reactive oxygen species levels in HNSCC cells were stu... περισσότερα »
18F-FDG-PET/CT for Evaluating the Response to Neoadjuvant Chemotherapy in Advanced Esophageal Cancer
18F-Fluorodeoxyglucose Positron Emission Tomography for Evaluating the Response to Neoadjuvant Chemotherapy in Advanced Esophageal Cancer: Background/Aim: The purpose of the present study was to improve the diagnostic precision of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after neoadjuvant chemotherapy (NAC) in patients with advanced esophageal cancer. Patients and Methods: Thirty patients underwent FDG-PET/CT before and after NAC. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were measured. Patients were ... περισσότερα »
Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction
in Advanced NSCLC: A Meta-Analysis: Background/Aim: The addition of amifostine to chemoradiotherapy (CRT) or radiotherapy (RT) in advanced, inoperable NSCLC presents varying toxicity. The present study examined amifostine's effect on toxicity and efficacy of CRT or RT alone. Materials and Methods: Database searches yielded 16 eligible trials comprising of 1,057 patients. Results of randomised trials were pooled and used to estimate the overall effect. Results: Amifostine reduced the risk of >grade 2 acute oesophagitis by 26% [risk ratio (RR), 0.74; 95% confidence interval (CI)=0.6... περισσότερα »
CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer
CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer: AbstractCysteine-rich C-terminal 1 (CRCT1) is encoded by the epidermal differentiation complex (EDC), a gene cluster that was recently linked to esophageal cancer. However, the role of CRCT1 in esophageal squamous cell cancer (ESCC) and the underlying mechanism remain unclear. In the present study, we show that CRCT1 is downregulated in ESCC in association with TNM stage and lymph node metastasis. Restoring CRCT1 in ESCC cells by lentivirus-mediated gene transfer inhib...περισσότερα »
Primary cutaneous T-cell lymphomas (CTCLs), such as mycosis fungoides and Sézary syndrome
Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Cutaneous T-cell lymphomas via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 2 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Pier Luigi Zinzani, Vijayveer Bonthapally, Dirk Huebner, Richard Lutes, Andy Chi, Stefano Pileri Primary cutaneous T-cell lymphomas (CTCLs), such as mycosis fungoides and Sézary syndrome, are a rare group of non-Hodgkin lymphomas, usually treated using a multimodal approach. Unfortunately, many ... περισσότερα »
The association of visceral adipose tissue and subcutaneous adipose tissue with metabolic risk factors in a large population of Chinese adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Objective Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults Methods This study was based on cross-sectional analysis of data from 1,449 adults […]
CME: Therapieoptionen der Divertikelkrankheit
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
„Sackgassen“ im Dickdarm Kolondivertikel gehören zu den häufigsten Befunden im Gastrointestinaltrakt. Eine neue deutsche Leitlinie unterscheidet 4 Typen. Welche Therapieoptionen es gibt, wann die stationäre Einweisung angezeigt ist und welchen Stellenwert die Antibiose hat, lesen Sie hier. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ra8vW0 via IFTTT
CME: Therapieoptionen der Divertikelkrankheit
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
„Sackgassen“ im Dickdarm Kolondivertikel gehören zu den häufigsten Befunden im Gastrointestinaltrakt. Eine neue deutsche Leitlinie unterscheidet 4 Typen. Welche Therapieoptionen es gibt, wann die stationäre Einweisung angezeigt ist und welchen Stellenwert die Antibiose hat, lesen Sie hier. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ra8vW0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 […]
Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Brain from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTM7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Autophagy and neurodegeneration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
The Journal of Clinical Investigation from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTM0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Extensive introgression in a malaria vector species complex revealed by phylogenomics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Science (New York, N.Y.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTLW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cell competition: Winning out by losing notch
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Cell Cycle from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OEtqcZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Biochemical and biophysical research communications from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTvA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A secretagogin locus of the mammalian hypothalamus controls stress hormone release
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
The EMBO Journal from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTvu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Comparison of Echocardiographic and Pressure–volume Loop Indices of Systolic Function in Patients with Single Ventricle Physiology: A Preliminary Report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Congenital heart disease from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OEtoBJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Langerhans cell sarcoma of the head and neck
Langerhans cell sarcoma of the head and neck via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 2 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): James E.F. Howard, Liam Masterson, Raghav C. Dwivedi, Piyush Jani Head and neck Langerhans cell sarcoma (HNLCS) is a rare malignant tumor of Langerhans cells carrying a poor prognosis. The aim of this work was to perform a systematic review of HNLCS cases, examine outcomes, and develop an evidence-based management algorithm. We performed a systematic literature search yielding ... περισσότερα »
Atypical location of the hypoglossal nerve and its implications
Atypical location of the hypoglossal nerve and its implications: a case report: Abstract IntroductionSuccessful surgery in the neck is dependent on reliable anatomical relationships between nerves, vessels, and muscles. These landmarks and planes are also essential to avoiding undue morbidity and mortality. Anatomic variants of the hypoglossal nerve are rare, and their incidences are unknown. MethodsWe describe a case of a hypoglossal nerve found coursing superficial to the internal jugular vein in a 52-year-old woman treated with bilateral selective neck dissection for metast... περισσότερα »
Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp
Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review: Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the ... περισσότερα »
CT-scan guided fine needle aspiration (FNA)
Metastatic Chordoma: A Diagnostic Challenge on Fine Needle Aspiration: Chordomas are primary low grade malignant tumors of bone that usually arise within both ends of axial skeleton. The Notochord is a midline, ectoderm-derived structure that defines the phylum of chordates. Chordomas may pose difficult diagnostic challenges when encountered in secondary locations, such as lungs or other parenchymatous organs. We report the cytologic findings of a metastatic chordoma sampled through CT-scan guided fine needle aspiration (FNA) of lower lobe lung nodule in a 54-year-old man diagnosed ...περισσότερα »
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy
With great interest we have read the articles of Petersen et al. and Wiegell et al. concerning the development of erythema following daylight-activated photodynamic therapy (PDT). Recently, daylight-activated PDT (DL-PDT) has been introduced as an attractive alternative for conventional PDT (cPDT). This article is protected by copyright. All rights reserved. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1JSwnFv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Me...περισσότερα »
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver metabolic and signaling proteins were simultaneously evaluated with cIEF immunoassays, using nanograms of total cellular protein per assay. Changes to liver protein acetylation, pho... περισσότερα »
Microcephaly
[image: start-here.png] *Microcephaly:* An abnormally small head due to failure of brain growth. Microcephaly is an ominous sign because it is almost always associated with developmental delay and mental retardation. Many factors can impair the growth of the brain, including intrauterine infections (such as rubella, cytomegalovirus, and toxoplasmosis), intrauterine chemical exposure (such as in fetal alcohol syndrome), excessive radiation exposure (as in an atomic bomb explosion), chromosome abnormalities (such as trisomy 13 and trisomy 18), and genetic syndromes (such as Fanconi ... περισσότερα »
Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
Brain from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTM7 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5pa6R via IFTTT
Autophagy and neurodegeneration
The Journal of Clinical Investigation from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTM0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiKmB via IFTTT
A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining
Biochemical and biophysical research communications from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTvA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5pa6P via IFTTT
Extensive introgression in a malaria vector species complex revealed by phylogenomics
Science (New York, N.Y.) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTLW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5pa6L via IFTTT
Cell competition: Winning out by losing notch
Cell Cycle from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OEtqcZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiKmv via IFTTT
Cardiovascular complications in inflammatory bowel disease
Current drug targets from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OEtoBE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p7rM via IFTTT
Comparison of Echocardiographic and Pressure–volume Loop Indices of Systolic Function in Patients with Single Ventricle Physiology: A Preliminary Report
Congenital heart disease from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OEtoBJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p9Qv via IFTTT
A secretagogin locus of the mammalian hypothalamus controls stress hormone release
The EMBO Journal from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTvu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiK6f via IFTTT
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Human Molecular Genetics from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTf3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p7rH via IFTTT
Wilson’s disease and other neurological copper disorders.
The Lancet. Neurology from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoQQu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiK6b via IFTTT
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1
EMBO Reports from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OEtnOj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p7rF via IFTTT
Stem and progenitor cell dysfunction in human trisomies
EMBO Reports from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTeV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiLH4 via IFTTT
Latent Trajectory Classes for Alcohol-Related Blackouts from Age 15 to 19 in ALSPAC
Alcoholism, clinical and experimental research from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mZoTf1 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p9Qo via IFTTT
Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations observed with Ankylosing Spondylitis
Arthritis & rheumatology (Hoboken, N.J.) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1R6n4cV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiLH2 via IFTTT
Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing
Age and Ageing from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PFxlta via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p9Qj via IFTTT
Polymorphisms influencing prostate specific antigen concentration may bias genome-wide association studies on prostate cancer
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1R6n3Wd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O5p9Qh via IFTTT
Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov.
International Journal of Systematic and Evolutionary Microbiology from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PFxixs via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JoiK66 via IFTTT
Metastatic Chordoma on Fine Needle Aspiration
Metastatic Chordoma: A Diagnostic Challenge on Fine Needle Aspiration: Chordomas are primary low grade malignant tumors of bone that usually arise within both ends of axial skeleton. The Notochord is a midline, ectoderm-derived structure that defines the phylum of chordates. Chordomas may pose difficult diagnostic challenges when encountered in secondary locations, such as lungs or other parenchymatous organs. We report the cytologic findings of a metastatic chordoma sampled through CT-scan guided fine needle aspiration (FNA) of lower lobe lung nodule in a 54-year-old man diagnosed ...περισσότερα »
An alternative method to achieve one-lung ventilation by surgical pneumothorax in difficult lung isolation patient: a case report
An alternative method to achieve one-lung ventilation by surgical pneumothorax in difficult lung isolation patient: a case report: AbstractIt is challenging to establish one-lung ventilation in difficult airway patients. Surgical pneumothorax under spontaneous breathing to obtain well-collapsed lung is a feasible method for thoracic surgery. A 76-year-old man with right empyema was scheduled for decortication. The patient had limited mouth opening due to facial cellulitis extending from the left cheek to neck. Generally, lung isolation is achieved by double-lumen endotracheal tube ... περισσότερα »
Intraoperative Upper Extremity Position-Related Neurapraxia
The Use of Somatosensory Evoked Potentials to Determine the Relationship Between Intraoperative Arterial Blood Pressure and Intraoperative Upper Extremity Position-Related Neurapraxia in the Prone Surrender Position During Spine Surgery: A Retrospective Analysis.: BACKGROUND: Peripheral nerve injury is a significant perioperative problem. Intraoperative position-related neurapraxia may indicate impending peripheral nerve injury and can be detected by changes in somatosensory evoked potentials (SSEP). The purpose of this retrospective analysis of spine surgeries performed under gener... περισσότερα »
Infection ostéo-cutanée du coude à Mycobacterium marinum
et reconstruction par un lambeau en hélice basé sur une perforante de l’artère collatérale radiale postérieure via Plastique Esthétique *Source:*Annales de Chirurgie Plastique Esthétique Author(s): P.-E. Gabert, L. Lievain, A. Vallée, P. Joly, I. Auquit Auckbur Mycobacterium Marinum est une mycobactérie atypique, non tuberculeuse principalement responsable d’infections cutanées. Elles surviennent après exposition d’une plaie à un aquarium ou à un poisson infecté. Son évolution, en l’absence de traitement adapté, est marquée par une extension des lésions et une diffusion aux tissus pr... περισσότερα »
YouTube as a source of information on mouth (oral) cancer
YouTube as a source of information on mouth (oral) cancer: Abstract Objectives We examined the content of YouTube ™ videos on mouth (oral) cancer, and evaluated their usefulness in promoting early detection of oral cancer. Material and methods A systematic search of YouTube ™ for videos containing information on mouth cancer was conducted using the keywords ‘mouth cancer’ and ‘oral cancer’. Demographics of videos, including type, source, length, and viewers’ interaction, were evaluated, and three researchers independently assessed the videos for usefulness in promoting early detectio...περισσότερα »
Neoplasms medial to the condyle: a condylectomy with anterior displacement of the condyle
A novel approach to via Oral and Maxillofacial Surgery [image: alertIcon.gif] Publication date: Available online 31 December 2015 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): Z.-X. Ye, C. Yang, M.-J. Chen, A. Abdelrehem Resecting neoplasms involving the infratemporal space has a high risk of damaging critical nerves and vessels, in addition to joint form and function. The purpose of this study was to introduce a novel approach to lesions medial to the condyle, which comprises a condylectomy with anterior displacement of the condyle. The indications evalua... περισσότερα »
Vermilion symmetry to alveolar cleft defect in unilateral cleft lip repair
Correlation of vermilion symmetry to alveolar cleft defect in unilateral cleft lip repair Asymmetry is a major problem in repaired unilateral cleft lip (UCL). One of the important manifestations of this is the asymmetry of the vermilion. The aim of this study was to correlate the severity of the asymmetry in the vermilion to the size of the alveolar defect. Twenty patients aged between 6 and 18 months with complete unilateral cleft lip, alveolus, and palate were included. An impression of each patient's alveolus at the time of cheiloplasty was taken using silicon rubber base materia... περισσότερα »
Juvenile hyaline fibromatosis (JHF) is a rare progressive autosomal recessive disease that is characterised by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions
Unusual cause for gum hypertrophy and skin nodules in a child 1. Priyadharshini Rajendran1, 2. Balaganesh Karmegaraj2, 3. Mukul Vij3, 4. Julius Xavier Scott4 -Author Affiliations 1. 1Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India 2. 2Department of Pediatrics, Ganesh Hospital, Tuticorin, Tamil Nadu, India 3. 3Global Health City, Chennai, Tamil Nadu, India 4. 4Department of Paediatric Hemato-Oncology, Sri Ramachandra University , Chennai, Tamil Nadu, India 1. Correspondence toDr Balaganesh Karmegaraj, k... περισσότερα »
Cough, codeine and confusion
Cough, codeine and confusion: 1. David O Reilly1,2, 2. Mathew Thomas3, 3. Edina Moylett4 -Author Affiliations 1. 1School of Medicine, National University of Ireland, Galway, HSE West , Galway, Connacht, Ireland 2. 2Donegal Clinical Research Academy, Letterkenny General Hospital, HSE West, Letterkenny, Ulster, Ireland 3. 3Department of Paediatrics, Letterkenny General Hospital, HSE West, Letterkenny, Ulster, Ireland 4. 4Academic Department of Paediatrics, National University of Ireland, Galway, HSE West,Galway, Connacht, Ireland 1. Corresp... περισσότερα »
Improving influenza vaccination in chronically ill children
using a tertiary-care based vaccination clinic: Is there a role for the live-attenuated influenza vaccine (LAIV)? via ScienceDirect Publication: Vaccine [image: S0264410X.gif] Publication date: Available online 3 January 2016 *Source:*Vaccine Author(s): Joanna Merckx, Deirdre McCormack, Caroline Quach BackgroundChildren with underlying medical conditions should receive influenza vaccine (IV) yearly; yet this remains sub-optimal. We aimed to describe our experience with a tertiary-care hospital-based influenza vaccination clinic for this at-risk population.MethodsFrom October to Dece... περισσότερα »
Odontogenic myxoma with diffuse calcifications
: a case report and review of a rare histological feature via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 3 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Huda M. Hammad, Yousef M. Hasen, Abd-Albaset M. Odat, Abeer M. Mikdadi, Rima A. Safadi Calcifications have been rarely reported in odontogenic myxoma. We describe an additional case and review all reported cases.A 45-year-old female patient presented with a gingival swelling around a mobile mandibular left second molar. Radiographic ...περισσότερα »
Perygomaxillary disconnection during surgically assisted rapid palatal expansion
Three-dimensional effects of pterygomaxillary disconnection during surgically assisted rapid palatal expansion: a cadaveric study via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 3 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Stephan Christian Möhlhenrich, Ali Modabber, Mohammad Kamal, Ulrike Fritz, Andreas Prescher, Frank Hölzle ObjectiveThe aim of this study was to investigate the influence of pterygomaxillary disconnection on the transversal expansion of the maxilla.Study DesignFif...περισσότερα »
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy: With great interest we have read the articles of Petersen et al. and Wiegell et al. concerning the development of erythema following daylight-activated photodynamic therapy (PDT). Recently, daylight-activated PDT (DL-PDT) has been introduced as an attractive alternative for conventional PDT (cPDT). This article is protected by copyright. All rights reserved.
Latent Trajectory Classes for Alcohol-Related Blackouts from Age 15 to 19 in ALSPAC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Alcoholism, clinical and experimental research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTf1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
EMBO Reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OEtnOj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Stem and progenitor cell dysfunction in human trisomies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
EMBO Reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTeV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Age and Ageing from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxlta via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations observed with Ankylosing Spondylitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Arthritis & rheumatology (Hoboken, N.J.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R6n4cV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
International Journal of Systematic and Evolutionary Microbiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxixs via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Polymorphisms influencing prostate specific antigen concentration may bias genome-wide association studies on prostate cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R6n3Wd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Regional distribution of selective neuronal loss and microglial activation across the MCA territory after transient focal ischemia: quantitative versus semiquantitative systematic immunohistochemical assessment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Journal of Cerebral Blood Flow & Metabolism from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxigY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-13C2 glucose
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Journal of Cerebral Blood Flow & Metabolism from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxfBS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Brain from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTM7 via IFTTT
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver metabolic and signaling proteins were simultaneously evaluated with cIEF immunoassays, using nanograms of total cellular protein per assay. Changes to liver protein acetylation, ph... περισσότερα »
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Human Molecular Genetics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTf3 via IFTTT
Latent Trajectory Classes for Alcohol-Related Blackouts from Age 15 to 19 in ALSPAC
Alcoholism, clinical and experimental research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTf1 via IFTTT
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1
EMBO Reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OEtnOj via IFTTT
Stem and progenitor cell dysfunction in human trisomies
EMBO Reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mZoTeV via IFTTT
Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing
Age and Ageing from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxlta via IFTTT
Issue Cover (January 2016)
Cover image by Nico Angliker, Michael Burri, Mariana Zaichuk, Jean-Marc Fritschy and Markus A. Rüegg. from Neurology via xlomafota13 on Inoreader http://ift.tt/1PFsLv0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MOMLqv via IFTTT
Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations observed with Ankylosing Spondylitis
Arthritis & rheumatology (Hoboken, N.J.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R6n4cV via IFTTT
GSE74887 Transcriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation Microarray
Contributors : Ruben G de Bruin ; Lily Shiue ; Manuel Ares Jr ; Anton J van Zonneveld ; Eric P van der Veer Series Type : Expression profiling by array Organism : Homo sapiens Expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes of early, human atherosclerotic lesions, but abundant in… Continue reading GSE74887 Transcriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation Microarray
Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov.
International Journal of Systematic and Evolutionary Microbiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFxixs via IFTTT
GSE69743 Global transcriptome response of Staphylococcus xylosus in meat model
Contributors : Aurore Vermassen ; Anne de La Foye ; Régine Talon ; Sabine Leroy Series Type : Expression profiling by array Organism : Staphylococcus xylosus Staphylococcus xylosus is used as starter culture for sausage fermentation for a long time but the molecular mechanisms for its adaptation in meat remained unknown. A global transcriptomic approach… Continue reading GSE69743 Global transcriptome response of Staphylococcus xylosus in meat model
GSE66859 MAGE-A1 Promotes Proliferation, Migration and Invasion of Human Melanoma Cells through RNA-SEQ Analysis via Affecting C-JUN-IL8-ARHGAP29 Network
Contributor : Xiangdong Fang Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens To define the role of MAGE-A1 in melanoma growth and metastasis, we performed RNA-seq analysis on MAGE-A1 overexpression (OE) and knockdown (KD) models in A375 human melanoma cell line. Our results revealed that overexpression of MAGE-A1 dramatically promoted… Continue reading GSE66859 MAGE-A1 Promotes Proliferation, Migration and Invasion of Human Melanoma Cells through RNA-SEQ Analysis via Affecting C-JUN-IL8-ARHGAP29 Network
GSE74887 Transcriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation Microarray
Contributors : Ruben G de Bruin ; Lily Shiue ; Manuel Ares Jr ; Anton J van Zonneveld ; Eric P van der Veer Series Type : Expression profiling by array Organism : Homo sapiens Expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes of early, human atherosclerotic lesions, but abundant in… Continue reading GSE74887 Transcriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation Microarray
GSE39318 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: TP53inp2 (DOR) RNAi knock-downs
Contributors : Josep M Mercader ; Montserrat Puiggros ; Ayellet V Segrè ; Evarist Planet ; Eleonora Sorianello ; David Sebastian ; Sergio Rodriguez-Cuenca ; Vicent Ribas ; Sílvia Bonàs-Guarch ; Sorin Draghici ; Chenjing Yang ; Sílvia Mora ; Antoni Vidal-Puig ; Josée Dupuis ; Jose C Florez ; Antonio Zorzano ; David Torrents… Continue reading GSE39318 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: TP53inp2 (DOR) RNAi knock-downs
GSE39319 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: Pgc1b knock-out hearts
Contributors : Josep M Mercader ; Montserrat Puiggros ; Ayellet V Segrè ; Evarist Planet ; Eleonora Sorianello ; David Sebastian ; Sergio Rodriguez-Cuenca ; Vicent Ribas ; Sílvia Bonàs-Guarch ; Sorin Draghici ; Chenjing Yang ; Sílvia Mora ; Antoni Vidal-Puig ; Josée Dupuis ; Jose C Florez ; Antonio Zorzano ; David Torrents… Continue reading GSE39319 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: Pgc1b knock-out hearts
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver… Continue reading Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
GSE64642 SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
Contributors : Huize Pan ; Dee Guan ; Jingyi Li ; Xiaomeng Liu ; Guanhui Liu ; Fuchou Tang Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human… Continue reading GSE64642 SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
Microcephaly
Microcephaly: An abnormally small head due to failure of brain growth. Microcephaly is an ominous sign because it is almost always associated with developmental delay and mental retardation. Many factors can impair the growth of the brain, including intrauterine infections (such as rubella, cytomegalovirus, and toxoplasmosis), intrauterine chemical exposure (such as in fetal alcohol syndrome),… Continue reading Microcephaly
GSE73745 Whole-genome saliva and blood DNA methylation patterns in individuals with a respiratory allergy
Contributors : Sabine S Langie ; Katarzyna Szarc vel Szic ; Sophie Traen ; Ken Declerck ; Gudrun Koppen ; Guy Van Camp ; Greet Schoeters ; Wim Vanden Berghe ; Patrick De Boever Series Type : Methylation profiling by array Organism : Homo sapiens It has been suggested that the etiology of respiratory allergies… Continue reading GSE73745 Whole-genome saliva and blood DNA methylation patterns in individuals with a respiratory allergy
Microcephaly
Microcephaly: An abnormally small head due to failure of brain growth. Microcephaly is an ominous sign because it is almost always associated with developmental delay and mental retardation. Many factors can impair the growth of the brain, including intrauterine infections (such as rubella, cytomegalovirus, and toxoplasmosis), intrauterine chemical exposure (such as in fetal alcohol syndrome),… Continue reading Microcephaly
Issue Cover (January 2016)
[image: Thumbnail image of graphical abstract] Cover image by Nico Angliker, Michael Burri, Mariana Zaichuk, Jean-Marc Fritschy and Markus A. Rüegg. from Neurology via xlomafota13 on Inoreader http://ift.tt/1PFsLv0 via IFTTT
Molecular Classification of Fatty Liver by High-Throughput Profiling of Protein Post-translational Modifications
Abstract We describe an alternative approach to classifying fatty liver by profiling protein post-translational modifications (PTM) with high-throughput capillary isoelectric focusing (cIEF) immunoassays. Four strains of mice were studied, with fatty livers induced by different causes, such as aging, genetic mutation, acute drug usage, and high-fat diet. Nutrient-sensitive PTM of a panel of twelve liver metabolic and signaling proteins were simultaneously evaluated with cIEF immunoassays, using nanograms of total cellular protein per assay. Changes to liver protein acetylation, ph... περισσότερα »
Microcephaly
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Microcephaly: An abnormally small head due to failure of brain growth. Microcephaly is an ominous sign because it is almost always associated with developmental delay and mental retardation. Many factors can impair the growth of the brain, including intrauterine infections (such as rubella, cytomegalovirus, and toxoplasmosis), intrauterine chemical exposure (such as in fetal alcohol syndrome), […]
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the […]
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The […]
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and […]
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR […]
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted […]
Novel stent in the palliation of malignant esophageal strictures: a retrospective study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary The placement of metal stents is often used as a palliative treatment for malignant esophageal stenosis. We designed a novel stent that has been used clinically since 2011, and we therefore performed a retrospective study to compare the therapeutic effects of this novel metal stent to a conventional partially covered metal stent in patients […]
Improving influenza vaccination in chronically ill children using a tertiary-care based vaccination clinic: Is there a role for the live-attenuated influenza vaccine (LAIV)?
[image: S0264410X.gif] Publication date: Available online 3 January 2016 *Source:*Vaccine Author(s): Joanna Merckx, Deirdre McCormack, Caroline Quach BackgroundChildren with underlying medical conditions should receive influenza vaccine (IV) yearly; yet this remains sub-optimal. We aimed to describe our experience with a tertiary-care hospital-based influenza vaccination clinic for this at-risk population.MethodsFrom October to December 2012, 2013, and 2014, we ran an influenza vaccination clinic at the Montreal Children's Hospital, where children with high-risk conditions come for ...περισσότερα »
Burden of four vaccine preventable diseases in older adults
[image: S0264410X.gif] Publication date: Available online 3 January 2016 *Source:*Vaccine Author(s): Maartje Kristensen, Alies van Lier, Renske Eilers, Scott A. McDonald, Wim Opstelten, Nicoline van der Maas, Wim van der Hoek, Mirjam E. Kretzschmar, Mark M. Nielen, Hester E. de Melker BackgroundImplementation of additional targeted vaccinations to prevent infectious diseases in the elderly is under discussion in different countries. When considering the added value of such preventive measures, insight in the current disease burden will assist in prioritization. The aim of this study... περισσότερα »
Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
[image: 53338eq1.jpg] Saturable and reverse saturable scattering were discovered in isolated plasmonic particles and adopted as a novel non-bleaching contrast method in super-resolution microscopy. Here the experimental procedures of detecting and extracting nonlinear scattering are explained in detail, as well as how to enhance resolution with the aid of saturated excitation microscopy. from #Medicine via ola Kala on Inoreader http://ift.tt/1TylAWF Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the […]
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The […]
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and […]
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR […]
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted […]
Novel stent in the palliation of malignant esophageal strictures: a retrospective study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary The placement of metal stents is often used as a palliative treatment for malignant esophageal stenosis. We designed a novel stent that has been used clinically since 2011, and we therefore performed a retrospective study to compare the therapeutic effects of this novel metal stent to a conventional partially covered metal stent in patients […]
GSE39318 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: TP53inp2 (DOR) RNAi knock-downs
Contributors : Josep M Mercader ; Montserrat Puiggros ; Ayellet V Segrè ; Evarist Planet ; Eleonora Sorianello ; David Sebastian ; Sergio Rodriguez-Cuenca ; Vicent Ribas ; Sílvia Bonàs-Guarch ; Sorin Draghici ; Chenjing Yang ; Sílvia Mora ; Antoni Vidal-Puig ; Josée Dupuis ; Jose C Florez ; Antonio Zorzano ; David Torrents… Continue reading GSE39318 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: TP53inp2 (DOR) RNAi knock-downs
GSE74222 Transcriptomic study (RNAseq) of Brachypodium distachyon ecotypes Bd21 and Bd2-3 under submergence stress
Contributors : Julián M Peña-Castro ; Piyada Juntawong Series Type : Expression profiling by high throughput sequencing Organism : Brachypodium distachyon Purpose: The goal of this study is to compare the transcriptomes expressed during submergence stress of two Brachypodium distachyon ecotypes with contrasting survival under this stress. Bd21 is a submergence sensitive ecotype with EC50… Continue reading GSE74222 Transcriptomic study (RNAseq) of Brachypodium distachyon ecotypes Bd21 and Bd2-3 under submergence stress
GSE69743 Global transcriptome response of Staphylococcus xylosus in meat model
Contributors : Aurore Vermassen ; Anne de La Foye ; Régine Talon ; Sabine Leroy Series Type : Expression profiling by array Organism : Staphylococcus xylosus Staphylococcus xylosus is used as starter culture for sausage fermentation for a long time but the molecular mechanisms for its adaptation in meat remained unknown. A global transcriptomic approach… Continue reading GSE69743 Global transcriptome response of Staphylococcus xylosus in meat model
GSE73745 Whole-genome saliva and blood DNA methylation patterns in individuals with a respiratory allergy
Contributors : Sabine S Langie ; Katarzyna Szarc vel Szic ; Sophie Traen ; Ken Declerck ; Gudrun Koppen ; Guy Van Camp ; Greet Schoeters ; Wim Vanden Berghe ; Patrick De Boever Series Type : Methylation profiling by array Organism : Homo sapiens It has been suggested that the etiology of respiratory allergies… Continue reading GSE73745 Whole-genome saliva and blood DNA methylation patterns in individuals with a respiratory allergy
GSE64642 SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
Contributors : Huize Pan ; Dee Guan ; Jingyi Li ; Xiaomeng Liu ; Guanhui Liu ; Fuchou Tang Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human… Continue reading GSE64642 SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
GSE39319 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: Pgc1b knock-out hearts
Contributors : Josep M Mercader ; Montserrat Puiggros ; Ayellet V Segrè ; Evarist Planet ; Eleonora Sorianello ; David Sebastian ; Sergio Rodriguez-Cuenca ; Vicent Ribas ; Sílvia Bonàs-Guarch ; Sorin Draghici ; Chenjing Yang ; Sílvia Mora ; Antoni Vidal-Puig ; Josée Dupuis ; Jose C Florez ; Antonio Zorzano ; David Torrents… Continue reading GSE39319 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: Pgc1b knock-out hearts
GSE70530 Hypoxia-induced alterations of G2 checkpoint regulators
Contributors : Grete Hasvold ; Christin Lund-Andersen ; Malin Lando ; Sebastian Patzke ; Sissel Hauge ; ZhenHe Suo ; Heidi Lyng ; Randi Syljuåsen Series Type : Expression profiling by array Organism : Homo sapiens Hypoxia promotes an aggressive tumor phenotype with increased genomic instability, partially due to downregulation of DNA repair pathways. However,… Continue reading GSE70530 Hypoxia-induced alterations of G2 checkpoint regulators
GSE39317 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: chronic insulin treatment
Contributors : Josep M Mercader ; Montserrat Puiggros ; Ayellet V Segrè ; Evarist Planet ; Eleonora Sorianello ; David Sebastian ; Sergio Rodriguez-Cuenca ; Vicent Ribas ; Sílvia Bonàs-Guarch ; Sorin Draghici ; Chenjing Yang ; Sílvia Mora ; Antoni Vidal-Puig ; Josée Dupuis ; Jose C Florez ; Antonio Zorzano ; David Torrents… Continue reading GSE39317 Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: chronic insulin treatment
Bernie Sanders supporters confident about primary – WMUR Manchester
WMUR Manchester Bernie Sanders supporters confident about primary WMUR Manchester “And what are you going to get when you’re 90 years old dealing with cancer or heart disease?” Sanders asked. “Not much! Needless to say that’s a pretty …. Unfortunately, Trump speaks with forked tongue. Lot’s of talk but extremely lacking in substance. Sent: Saturday,… Continue reading Bernie Sanders supporters confident about primary – WMUR Manchester
Your New Springer Books in January
New Book Alert 04.01.2016 Dear SpringerAlerts Subscriber, Please find below all print books and eBooks in your fields of interest published in the last month. With best regards, Your SpringerAlerts Team P.S.: Click here to find out more about Springer eBooks for Institutions. Important News Papers, the reference manager, for iPhone and iPad now totally… Continue reading Your New Springer Books in January
Novel stent in the palliation of malignant esophageal strictures: a retrospective study
Summary The placement of metal stents is often used as a palliative treatment for malignant esophageal stenosis. We designed a novel stent that has been used clinically since 2011, and we therefore performed a retrospective study to compare the therapeutic effects of this novel metal stent to a conventional partially covered metal stent in patients… Continue reading Novel stent in the palliation of malignant esophageal strictures: a retrospective study
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The… Continue reading Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the… Continue reading Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The… Continue reading Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR… Continue reading Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and… Continue reading Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and… Continue reading Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR… Continue reading Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted… Continue reading External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted… Continue reading External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the […]
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The […]
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and […]
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR […]
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted […]
Novel stent in the palliation of malignant esophageal strictures: a retrospective study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary The placement of metal stents is often used as a palliative treatment for malignant esophageal stenosis. We designed a novel stent that has been used clinically since 2011, and we therefore performed a retrospective study to compare the therapeutic effects of this novel metal stent to a conventional partially covered metal stent in patients […]
Your New Springer Books in January
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: Springer Alert] New Book Alert 04.01.2016 Dear SpringerAlerts Subscriber, Please find below all print books and eBooks in your fields of interest published in the last month. With best regards, Your SpringerAlerts Team P.S.: Click here to find out more about Springer eBooks for Institutions. Important News Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://papersapp.com/ios. » More...... περισσότερα »
Cough, codeine and confusion
David O Reilly, Mathew Thomas, Edina Moylett<br>Dec 23, 2015; 2015:201521272-201521272<br>case-report from Cases via ola Kala on Inoreader http://ift.tt/1mYVPEz via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R9Ogrq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R6cT86 via IFTTT
Unexpected cause of respiratory distress
Joana Sotto Mayor, Ana Lages, Sofia Esperanca, Antonio Oliveira e Silva<br>Dec 23, 2015; 2015:201521340-201521340<br>case-report from Cases via ola Kala on Inoreader http://ift.tt/1UpbCHa via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NZrzCc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VAminE via IFTTT
