OtoRhinoLaryngology & Medicine,New Articles,August 19th,2016

08:39

OtoRhinoLaryngology - Alexandros G. Sfakianakis

No preventive effect on the development of allergic disease of the supplementation of ω3 polyunsaturated fatty acids, vitamins or minerals has been demonstrated when administered to children and/or their mother during pregnancy or breastfeeding.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:38

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Essential fatty acids are precursors of LCP, the synthesis of which is achieved through sequential enzymatic reactions of chain elongation (elongase) and desaturation (desaturase). The enzymes involved in the reactions of elongation and desaturation of these fatty acids are common to the two biosynthetic pathways (ω-3 and ω-6 series) and display a “competing for substrate” mechanism (Fig. 1). Eicosapentaenoic acid (EPA, C20: 5 ω-3) and docosahexaenoic acid (DHA, C22: 6 ω-3) are derived from acid α-linolenic acid and arachidonic acid (AA, C20: 4 ω-6). is derived from linoleic acid. Eicosapentaenoic acid (ω-3), docosahexaenoic acid (ω-3) and arachidonic acid (ω-6) have particular biological significance as fundamental components of cell membranes (especially in the brain and retina). They are precursors of eicosanoids, compounds which consist of 20 carbon atoms (from the Greek éikosi), and are highly bioactive, acting as intercellular mediators and/or locally-acting and controlling hormones. Arachidonic acid it is the predominant precursor, present in high concentrations in all membrane phospholipids. Three different enzyme systems oxidize AA: cyclooxygenase (with training prostaglandins and thromboxanes), lipoxygenase (with the production of leukotrienes) and cytochrome P450 monooxygenase (forming 19- and 20-HETE). The biological activities of eicosanoids are varied: for example, prostaglandin E2 (PGE2) acts on blood vessels, airways, the stomach, the kidneys, neutrophil function, lymphocytes and pain receptors. Even ω-3 fatty acids can be used for the synthesis of eicosanoids, which, however, have opposed characteristics from AA-derived eicosanoids, determining smooth muscle relaxation and vasodilatation (prostacyclins). For this reason, the mechanism of competition for substrate has a very precise meaning: ω-6 fatty acids, in fact, are much more abundant in nature and in the “Western” diet, but enzymatic chain processing favours ω-3 fatty acids when present. Long-chain polyunsaturated fatty acids are best known for their possible effects on the central nervous system as a component of cell membranes, but they are also associated with the modulation of immune responses as precursors of eicosanoids [90]. The “anti-inflammatory” effect of EPA and DHA (found in fish and, in particular, their oils) is based on a competitive mechanism: at the membrane level, these LCPUFA of the ω-3 series replace AA (from which highly inflammatory eicosanoids are derived) and determines decidedly bland inflammatory eicosanoid activities. The intake of fish oil would, therefore, exert a potentially anti-inflammatory effect. In contrast, the increased consumption of vegetable oils rich in ω-6 polyunsaturated fatty acids is one of the main dietary factors in the allergic epidemic [93, 94, 95].

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:37

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The “classical” Th1/Th2 dichotomy and the Th17 line. The classic paradigm of the Th1/Th2 dichotomy has been made obsolete by the discovery of other cell lines. There are CD4 + T-helper cells expressing interleukin 17 (IL-17) and numerous categories of regulatory T cells (Treg) able to control effector T-cell responses have been described. While, strictly speaking, Tregs cells originate directly from thymic precursors, inducible Treg cells (iTreg) cells and Tr1 cells Th3 differ from precursors of peripheral T-helper cells through the action of several cytokines such as TG F-β, IL-2 and retinoic acid (Fig. 1). Th17 cells play a role in the immune response to self and, along the two “classic” Th1 and Th2 cell lines and Treg, represent not only a key component of the innate immune response to infection, but also exert a pro-inflammatory effect and promote tissue damage in various chronic inflammatory diseases such as asthma [98]. Recent studies have confirmed a role of this cell line in the pathogenesis of asthma in children of school age [98, 99]. Other evidence for the hygiene hypothesis consisted in the observation of a reduced rate of allergies among children living in countries with low sanitary conditions and lower health education (associated with an increased incidence among immigrants from these countries in the West) or amid children who have contracted tuberculosis or measles, of an inverse correlation between risk of developing allergy and family educational level, as well as vaccination for measles or conditions conducive to infections, such as a large number of siblings and early age at first exposure to community contacts [97].

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:37

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Definition of wheezing according to the definitions of the European Respiratory Society [107] Temporal pattern of wheezing Episodic (viral) Wheezing during discrete periods of time, often in association with clinical evidence of viral cold, in the absence of wheezing in the inter-critical periods Multiple-trigger Wheezing with exacerbations over time, but also symptoms during periods between one episode and the other Duration of wheezing Transitory Symptoms that begin before 3 years and disappeared (retrospectively) within 6 years; wheezing transition can be either episodic or multiple-triggered Persistent Symptoms that persisted (retrospectively) over 6 years; persistent wheezing can be either episodic or multiple-triggered Late-onset Symptoms begin after 3 years of age; either episodic or multiple-triggered

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:36

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Risk factors for the development of asthma (modified Asthma Predictive Index or API) for children with wheezing (modified from reference [110]). ≥4 episodes wheezing last year associated with: One major criterion: •One parent with asthma •Atopic dermatitis •Sensitisation to inhalant allergen or Two minor criteria: •Sensitisation to foods •Wheezing outside of infective episode •Eosinophilia (>4 %) A positive API index is associated with an increased probability of developing asthma between 6 and 13 years from 4- to 10-fold. More than 95 % of children with negative API score in the first 3 years of life do not develop asthma between 6 and 13 years.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:35

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Early entry into the community cannot be considered a risk factor for the development of allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:35

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Early community exposure is not recommended to prevent the development of allergy

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:34

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The existence of a relationship between latitude and its consequent degree of ultraviolet radiation exposure, vitamin D levels and the prevalence and severity of allergic diseases, the data of observational studies are encouraging, but controversial and the only available RCT fails to show an effect on allergic disease prevalence. The use of vitamin D supplementation for the primary prevention of allergic diseases remains an attractive topic of study, but current knowledge and available evidence does not warrant its recommendation [129]. Several randomised controlled trials are underway and they will certainly inform future recommendations on the basis of more solid evidence. Recommendation . On basis of the available evidence, the use of vitamin D supplementation is not recommended for the primary prevention of allergic disease.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:33

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Favourable effects of the administration of probiotics to breast- or formula-fed infants remain unclear when probiotics were not supplemented pre- or post-natally to their mothers. No administration modality exerts a preventive effect on asthma, rhinitis or prevents allergies. The safety profile is excellent, and significant adverse events in the treated groups were not found in any revised literature. Supplementation of probiotics to prevent allergic diseases cannot be recommended on the basis of the available evidence. Encouraging data on a possible reduction in the risk of atopic dermatitis should be interpreted with great caution as 25 infants have to be treated to prevent a single case of dermatitis and several studies suffer from a high percentage of patients lost to follow-up. Recommendation : supplementation with probiotics The administration of probiotics for the prevention of asthma, rhinitis and food allergy cannot be recommended as available studies demonstrated their ineffectiveness in the literature. The administration of probiotics to the mother during pregnancy and/or after delivery, and in together with their child during the first 6 months of life, can be considered as an intervention for the prevention of atopic dermatitis, even in the infrequent cases in which the prevailing trigger is food, among children at risk. The effect is moderate but constant across studies available in the literature. Recommendation supplementation with prebiotics At the state of knowledge no recommendations of the use of prebiotics can be issued.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:32

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Evidence of recommendation for anti-mite measures Action on Type of intervention Level recommendation Facilitating factors Hygrometer Strong Dehumidifier Strong Central air conditioner None Allergenic source Dry Strong Acaricides Not recommended Freezing None Reservoir HEPA vacuum cleaners Strong Pillowcases, mattress Strong Pillowcases, pillow Strong Kit for quantitative evaluation Poor Denaturing agents Not recommended

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:31

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Recommendations for action to reduce mite allergen exposure. - Reduce the level of relative humidity in the house, keeping it at around 50 %. Use hygrometers and, possibly, a dehumidifier; - Use pillow and mattress covers and cushion covers made of fabric labelled “antimite”; - Eliminate allergen sources/reservoirs such as carpets, rugs, curtains, stuffed animals; - Hoover periodically with a vacuum-cleaner that can retain allergen in a HEPA filter; - A multifaceted approach that includes all the previously described measures is likely to be more effective and is thus recommended; - Measures targeted at the physical elimination of mites (washing at high temperatures > 60 ° C, freezing, drying) are theoretically effective and can be recommended but clinical trials are lacking that show their effectiveness; - The use of acaricides is not recommended (limited effectiveness and possible toxicity)

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:31

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Limited exposure to mite allergen improves the clinical status of sensitised children with respiratory or skin disease (atopic dermatitis). Recommendation Primary prevention of mite sensitisation is possible only through a comprehensive environmental monitoring strategy that must be assessed on a case by case basis and discussed in detail with the family.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:30

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Recommendation : In Western countries, children and adolescents spend most of their time in indoors: all interventions designed to reduce exposure to risk factors as much as possible should include tobacco smoke and indoor allergens (house dust mites, moulds and dog and cat epithelia in particular) represent an important opportunity for prevention.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:29

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Cigarette smoking is the main source of indoor air pollution. The harmful effects of smoking are mediated by irritant, mutagenic and immunological mechanisms which promote the development of many diseases. It is essential to be aware of smoke-related diseases and to promote a smoke-free environment for children.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:29

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The association between exposure to smoking in childhood and risk of atopic sensitisation has been extensively studied, but the literature offers no consensus on this topic. However, the severity of smoke-related diseases suggest recommending absolute avoidance of exposure to second-hand smoke, regardless of the possibility that smoking may promote allergic sensitisation.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.

08:27

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Asthma and allergic rhinitis are strongly correlated with exposure to mould during the first year of life in children and adolescents. Prevention for exposure to mould has been demonstrated to be important in preventing allergic sensitisation. Avoidance of allergen exposure is crucial for children with documented mould allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatricsby Giuseppe di Mauro, Roberto Bernardini, Salvatore Barberi, Annalisa Capuano, Antonio Correra, Gian...

08:25

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Prevention of food and airway allergy

: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades.Giuseppe di Mauro†,Roberto Bernardini†,Salvatore Barberi,Annalisa Capuano,Antonio Correra,Gian Luigi de’...

08:23

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Mango leaf extract

 improves central pathology and cognitive impairment in a type 2 diabetes mouse model: AbstractEpidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes...

08:23

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects: This case series describes outcomes for patients with medial canthal defects managed with lateral rotational and glabellar surgical flaps and provides a surgical procedure video illustrating the technique.Surgical Pearls | August 18, 2016Combination...

08:22

OtoRhinoLaryngology - Alexandros G. Sfakianakis

OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortex invasion could be an independent prognostic factor for patients

Does medullary vs. cortical invasion of the mandible affect prognosis in patients with oral squamous cell carcinoma?via Oral and Maxillofacial SurgeryPublication date: Available online 18 August 2016Source:Journal of Oral and Maxillofacial SurgeryAuthor(s): Chunjie Li, Jie Lin, Yi Men, Wenbin Yang, Fanglin...

08:21

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Anaphylaxis

Decreasing the under-notification of anaphylaxis deaths in brazil through the international classification of diseases (ICD)-11 revision: AbstractBackgroundIn 2012, an analysis of the Brazilian mortality database demonstrated under-notification of anaphylaxis deaths due, at least in part, to difficult...

08:20

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Maternal active smoking and its risk of oral clefts

: a Meta-analysisvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: Available online 18 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Zhang Xuan, Yang Zhongpeng, Guo Yanjun, Dai Jiaqi, Zhu Yuchi, Shi Bing, Li ChenghaoObjectiveTo...

08:19

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Trigeminal Neuralgia

: A Retrospective Multicentre Study of 320 Asian Patientsvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: Available online 17 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Hans Prakash Sathasivam, Sumairi Ismail, Abdul Rahim...

08:18

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis

: a systematic review and meta-analysisvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologySource:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Jun Ju, Yun Li, Juan Chai, Chao Ma, Qianwei Ni, Zhiyuan Shen, Jianhua Wei, Moyi SunObjectiveWe performed a systematic...

08:18

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Diagnosis of oral lichen planus

: a position paper of the American Academy of Oral and Maxillofacial Pathologyvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 3Author(s): Yi-Shing Lisa Cheng, Alan...

08:17

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Increasing zoledronic acid concentrations,Early changes of the mandible in bisphosphonate-treated patients

Computed tomographic assessment of early changes of the mandible in bisphosphonate-treated patientsvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 3Author(s): Tohru...

08:15

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Wideband acoustic immittance measurements in assessing crimping status following stapedotomy

A temporal bone study:AbstractObjective: To ascertain if wideband acoustic immitance (WAI) measurements are useful in assessing crimping status following stapedotomy. Design: WAI measurements were obtained using the Mimosa Acoustics HearID system. Wideband chirp sound stimuli and a set of tone stimuli...

08:14

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Skills in audiology

A tool for assessing case history and feedback skills in audiology students working with simulated patients:AbstractObjective: To develop a tool for assessing audiology students taking a case history and giving feedback with simulated patients (SP). Design: Single observation, single group design. Study...

08:14

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The Consumer Quality Index (CQI) ‘Audiology Care’

Clients’ perspective on quality of audiology care: Development of the Consumer Quality Index (CQI) ‘Audiology Care’ for measuring client experiences:AbstractObjective: Clients’ perspective on the quality of audiology care has not been investigated thoroughly. Research has focused primarily on satisfaction...

08:13

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Analysis of the characteristics of persistent postural-perceptual dizziness

A clinical-based study in ChinaAbstractObjective: Persistent postural-perceptual dizziness (PPPD) is a common cause of chronic dizziness, but only a few studies have reported its clinical characteristics, and no related research has been performed in China. Therefore, the purpose of this study was to...

08:12

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Anpassung von Cochleaimplantatsystemen

Anpassung von Cochleaimplantatsystemen: ZusammenfassungBei der Cochleaimplantat(CI)-Anpassung wird der elektrische Dynamikbereich festgelegt, der vom CI-Träger für die Wahrnehmung von Schallereignissen genutzt werden kann. Bei allen CI-Herstellern ist eine große Flexibilität der Einstellung möglich,...

08:11

OtoRhinoLaryngology - Alexandros G. Sfakianakis

The inferior colliculus (IC) represents a midbrain nexus involved in numerous aspects of auditory processing

Differences in synaptic and intrinsic properties result in topographic heterogeneity of temporal processing of neurons within the Inferior Colliculusvia Hearing ResearchPublication date: Available online 17 August 2016Source:Hearing ResearchAuthor(s): Lina Yassin, Michael Pecka, Jasmin Kajopoulos, Helge...

08:09

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Analysis of VEMP and ECoG in Noise Induced Hearing Loss,Autologous Bone Grafts on Demand during Surgery with 3D CAD/CAM,Bacteriologic Evaluation of Chronic Otitis Media in Older Patients,Bilateral IAC or CPA Lesions in Children without NF2,Carbamazepine Treatment of Vestibulocochlear Nerve Hyperactivity,Changes in Endolymphatic Hydrops in Patients with Ménière’s Disease,A Community-based Hearing Intervention for Older,Discrete Vestibular Phenotypes in DFNA9 Families with COCH,The Effect of Temperature on the Specific Gravity of the Avian Cupula,Endolymphatic Sac Shunting with Local Steroid,Endolymphatic Space in Meniere’s and Non-otological Diseases,Endoscopic Assisted Middle Fossa Resection of Vestibular Schwannoma,Epley, Semont, and Brandt Daroff Maneuvers in the Treatment of BPPV,Expression of ATP6V0A4 in the Developing Mouse Cochlea,French Validation of the Barcelona Music Reward Questionnaire,Generation of Light-Sensitive Stem Cells Using Non-viral Methods,Hemorrhagic Labyrinthitis: A Human Temporal Bone Study,Incus-Footplate Assembly: Indication and Surgical Outcome,Leukoaraiosis: Is It Important to Presbycusis Prognosis?,Localization and Hearing in Noise: Osseointegrated Device Outcomes,Measuring Hearing in Older Adults by Self-report versus Audiometry,Medical and Bioethical Considerations in Cochlear Implant Removal,A Novel Canalplasty Technique for External Auditory Canal Exostoses,Oxidative Stress and Apoptosis Post-Cochlear Implantation Trauma,Papercraft Temporal Bone in the First Step Education of the Anatomy,The Perception of Visual Vertical in Patients with Migraine,Peripheral Vestibular Otopathology from Vestibular Schwannomas,A Prospective Study of Fore-Aft Vection in Subjects with Migraine,The ROTATE Test: A Novel Method of Assessing Saccule Function,Sensitivity and Specificity of Self-reported Hearing Loss,The Significance of Blood Profiles in Vestibular Neuritis,Spiral Ganglion Neurite Guidance by Topographic and Photochemical Cues,Stability of Bone-Anchored Implants: Punch Method and Early Loading,Steroid Effect on Hearing in Animal Models with Cochlear Implant,Suppression of Otoacoustic Emissions and Tinnitus Annoyance Levels,Suppurative Labyrinthitis: Sites and Degrees of Cochlear Pathology,Use of a Novel Bioplastic in Myringoplasty: An Animal Model,Ventilation Tube as First Line Intervention in Ménière’s Disease,Vestibular Evoked Myogenic Potential in Vestibular Schwannoma Cases,

http://oto.sagepub.com/content/153/1_suppl/P178.fullhttp://oto.sagepub.com/content/153/1_suppl/P178.full.pdf+html Next SectionAnalysis of VEMP and ECoG in Noise Induced Hearing LossAbdullah Dalgic, MD (presenter); Oguz Yılmaz; Yusuf Hidir; Bülent Satar; Mustafa GerekObjectives: Our objective was to analyze...

07:59

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Papercraft temporal bone in the first step of anatomy education

Article in PressPapercraft temporal bone in the first step of anatomy educationHarukazu HiraumiPress enter key for correspondence informationPress enter key to Email the author, Hiroaki Sato, Juichi ItoDOI: http://dx.doi.org/10.1016/j.anl.2016.07.017Article InfoAbstractFull TextImagesReferencesAbstractObjective(1)...

07:57

OtoRhinoLaryngology - Alexandros G. Sfakianakis

De Quervain's thyroiditis

Article in Pressde Quervain's thyroiditis: A review of experience with surgeryRohit Ranganath, MDPress enter key to Email the author, Manish A. Shaha, MD1,Press enter key to Email the author, Bin Xu, MDCM, PhD, FRCP(C)2,Press enter key to Email the author, Jocelyn Migliacci, MA3,Press enter key to Email...

07:56

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Pulsed Dye Laser Treatment of Primary Cryptococcal Laryngitis

Article in PressPulsed Dye Laser Treatment of Primary Cryptococcal Laryngitis: A Novel Approach to an Uncommon Disease☆☆☆Ezinne J. Ihenachor, BA, Karuna Dewan, MDPress enter key for correspondence informationPress enter key to Email the author, Dinesh Chhetri, MDUCLA, Department of Head and Neck SurgeryDOI: http://dx.doi.org/10.1016/j.amjoto.2016.08.007Article...

07:55

OtoRhinoLaryngology - Alexandros G. Sfakianakis

GJB2 gene mutation in cochlear implant patients

Main ArticlePrevalence of GJB2 gene mutation in 330 cochlear implant patients in the Jiangsu provinceL Shia1, J Chena1, J Lia1, X Weia1 and X Gaoa1 c1a1 Department of Otorhinolaryngology, Head and Neck Surgery, Drum Tower Hospital of Nanjing University Medical School, ChinaAbstractObjective: GJB2 gene...

07:54

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

Main ArticleGenetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patientsA Akyigita1 c1, Ş Yalcina2, E Ö Etema3, İ Kaygusuza2, T Karlidaga2, E Kelesa2, Z B Celika3and A Tektemura3a1 ENT Clinic, Elazığ Education and Research Hospitala2 Department of ENT, Firat University...

07:53

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Reconstruction of facial soft tissue

: comparison between conventional procedures and the face-lift technique: We compared the result of replacement using a modified face-lift technique with those of other commonly used surgical techniques for the treatment of defects of the soft tissue of the infraorbital and cheek region. We made a retrospective...

07:53

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer

Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer: AbstractBackgroundThe purpose of this study was to analyze the prognostic value of pretreatment count of peripheral neutrophils, lymphocytes, monocytes, and...

07:52

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Midbrain raphe hypoechogenicity in migraineurs

An indicator for the use of analgesics but not triptans: IntroductionThe involvement of the serotonergic system of the brainstem raphe in the pathogenesis of migraine is discussed. Here we studied brainstem alterations in migraineurs using transcranial sonography and examined their relation to clinical...

07:51

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Chronic headaches and the rectus capitis posterior minor muscle

Correlation between chronic headaches and the rectus capitis posterior minor muscle: A comparative analysis of cross-sectional trail: ObjectiveWe aimed to investigate the morphological changes and potential correlation between chronic headaches and the rectus capitis posterior minor muscle (RCPmi).MethodsComparison...

07:50

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Flat-panel computed tomography during cochlear implant surgery : Intraoperative data acquisition by Dyna-CT represents a suitable option for online surgical navigation during cochlear implant surgery

First use of flat-panel computed tomography during cochlear implant surgery: AbstractBackgroundCochlear implantation in routine cases with normal anatomy is commonly performed without intraoperative image guidance. Revision cochlear implantation as well as surgery in malformations require not only a...

07:50

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Bildgebende Diagnostik des Vestibularisschwannoms

Bildgebende Diagnostik des Vestibularisschwannoms: ZusammenfassungDie Magnetresonanztomographie (MRT) ist die Methode der Wahl in der Bildgebung des Vestibularisschwannoms mit nahezu 100 % Sensitivität und Spezifität. Der Stellenwert der Computertomographie (CT) ist auf die Operationsplanung und postoperative...

07:50

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Georg Schlöndorff – Vater der „computerassistierten Chirurgie“

Georg Schlöndorff – Vater der „computerassistierten Chirurgie“: ZusammenfassungGeorg Schlöndorff (1931–2011) entwickelte in seiner Zeit als Ordinarius für Hals-Nasen-Ohren-Heilkunde am Klinikum der RWTH Aachen 1985 die Idee der computerassistierten Chirurgie. Mithilfe von Ingenieuren und Physikern der...

07:49

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Tinnitus

Tinnitus Disappears Completely: Tinnitus is a ringing in the ears that sounds like a buzzing or humming noise even when there is no actual sound present. This ringing or humming noise may be present throughout the day or only occur when certain actions are taken like laying on your side while sleeping....

07:49

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Sports-related traumatic brain injury (TBI)

Neurosurgical Emergencies in Sports Neurology: AbstractPurpose of ReviewAthletic neurosurgical emergencies are injuries that can lead to mortality or significant morbidity and require immediate recognition and treatment. This review article discusses the epidemiology of sports-related traumatic brain...

07:49

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Upper Esophageal Sphincter (UES) Relaxation and Opening

Modulation of Upper Esophageal Sphincter (UES) Relaxation and Opening During Volume Swallowing: AbstractUES opening occurs following cricopharyngeus deactivation and submental muscle contraction causing hyolaryngeal elevation and UES distraction. During impedance manometry, the inverse of impedance (admittance)...

07:48

OtoRhinoLaryngology - Alexandros G. Sfakianakis

Foreign Body Aspiration : Times until treatment were not significantly associated with complications from foreign body aspiration

Do Times until Treatment for Foreign Body Aspiration Relate to Complications?: Introduction. Foreign body aspiration is an emergency condition and may be fatal. Delayed diagnosis and treatment may be associated with complications. This study evaluated the association between time until treatment and...

08:55

Cancer by Sfakianakis Alexandros

Medullary Thyroid Carcinoma: Recent Advances Including MicroRNA Expression

Abstract Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumor arising from the C cells in the thyroid and accounts for about 5 % of all thyroid cancers. MTC exhibits more aggressive behavior than follicular tumors, with the majority of cases presenting with lymph node metastasis. It...

08:35

Cancer by Sfakianakis Alexandros

Truth-Telling in Taiwanese Cancer Care: Patients’ and Families’ Preferences and their Experiences of Doctors’ Practices

Abstract Objective Despite the significant role played by cancer patients' families in medical decision-making in Asian countries, inconsistencies have hitherto not been evaluated between patients' and families' preferences and doctors' actual practices with regard to cancer truth telling. ...

08:35

Cancer by Sfakianakis Alexandros

The pivotal role of mammalian target of rapamycin inhibition in the treatment of patients with neuroendocrine tumors

Abstract Significant advances have been made toward understanding the biology of neuroendocrine tumors (NET) in terms of defining prognosis and improving clinical management; however, many unmet needs remain. The treatment landscape for NET has evolved, with the approval of the targeted agents everolimus...

08:35

Cancer by Sfakianakis Alexandros

The hedgehog pathway in triple-negative breast cancer

Abstract Treatment of triple-negative breast cancer (TNBC) remains challenging due to the underlying heterogeneity of this disease coupled with the lack of predictive biomarkers and effective targeted therapies. Intratumoral heterogeneity, particularly enrichment for breast cancer stem cell-like subpopulations,...

07:56

Cancer

Radiotherapy and Immunotherapy: Can this Combination Change the Prognosis of Patients with Melanoma Brain Metastases?

Publication date: Available online 18 August 2016Source:Cancer Treatment Reviews Author(s): D. Franceschini, C. Franzese, P. Navarria, A.M. Ascolese, F. De Rose, M. Del Vecchio, A. Santoro, M. Scorsetti Brain metastases are a common occurrence in patients with melanoma. Prognosis is poor. Radiotherapy...

05:51

Cancer

Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors

Background. A specific form of small-vessel vasculopathy—cerebral microbleeds (CMBs)—has been linked to various types of dementia in adults. We assessed the incidence of CMBs and their association with neurocognitive function in pediatric brain tumor survivors. Methods. In a multi-institutional...

05:51

Cancer

Adjuvant chemotherapy and overall survival in adult medulloblastoma

Background Although chemotherapy is used routinely in pediatric medulloblastoma (MB) patients, its benefit for adult MB is unclear. We evaluated the survival impact of adjuvant chemotherapy in adult MB. Methods Using the National Cancer Data Base, we identified patients aged 18 years and older who...

05:06

Cancer

An Observational Study to Evaluate Associations Between Low-Level Gestational Exposure to Organophosphate Pesticides and Cognition During Early Childhood

Prenatal exposure to organophosphate pesticides, which is ubiquitous, may be detrimental to neurological development. We examined 327 mother/infant pairs in Cincinnati, Ohio, between 2003 and 2006 to determine associations between prenatal exposure to organophosphate pesticides and neurodevelopment....

03:56

Cancer

Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location

Most studies of cutaneous head and neck melanomas (CHNM) have reported poorer survival in CHNM compared with other sites, especially on the scalp/neck. http://ift.tt/2b7Qy9s

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Cancer by Sfakianakis Alexandros

Impact of resection and systemic therapy on the survival of patients with brain metastasis of metastatic renal cell carcinoma

Abstract Patients with brain metastasis (BM) from renal cell carcinoma (RCC) are associated with poor prognosis. Between 1990 and 2015, data of consecutive RCC patients with BM were retrospectively analyzed from a urologic oncologic database. The treatment outcome was evaluated by overall survival (OS),...

03:56

Cancer by Sfakianakis Alexandros

BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia

Abstract Background Solid pseudopapillary neoplasms of the pancreas (SPN) are rare tumors affecting mainly women. They show an activating mutation in CTNNB1, the gene for β-catenin, and consequently an overactivation of the Wnt/β-catenin pathway. This signaling pathway is implied in the pathogenesis...

03:56

Cancer by Sfakianakis Alexandros

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma

Abstract Background Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive, fatal, childhood tumors that arise in the brainstem. DIPGs have no effective treatment, and their location and diffuse nature render them inoperable. Radiation therapy remains the only standard of care for this devastating...

03:56

Cancer by Sfakianakis Alexandros

p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading

Abstract Background Traditional prognostic indicators of breast cancer, i.e. lymph node diffusion, tumor size, grading and estrogen receptor expression, are inadequate predictors of metastatic relapse. Thus, additional prognostic parameters appear urgently needed. Individual oncogenic determinants...

03:56

Cancer by Sfakianakis Alexandros

Five-year disease-free survival among stage II-IV breast cancer patients receiving FAC and AC chemotherapy in phase II clinical trials of Panagen

Abstract Background We report on the results of a phase II clinical trial of Panagen (tablet form of fragmented human DNA preparation) in breast cancer patients (placebo group n = 23, Panagen n = 57). Panagen was administered as an adjuvant leukoprotective agent in FAC and AC chemotherapy regimens....

03:55

Cancer by Sfakianakis Alexandros

Original article: role of adjuvant chemotherapy in a perioperative chemotherapy regimen for gastric cancer

Abstract Background Multimodal treatment strategies – perioperative chemotherapy (CTx) and radical surgery – are currently accepted as treatment standard for locally advanced gastric cancer. However, the role of adjuvant postoperative CTx (postCTx) in addition to neoadjuvant preoperative CTx (preCTx)...

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Cancer

Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage

PURPOSE: We encountered a case where an infection with group A streptococcus (GAS; ie, Streptococcus pyogenes) initially caused primary peritonitis and then subsequently caused streptococcal toxic shock syndrome. The patient's life was likely saved by an emergency laparotomy followed by extensive peritoneal...

Thu Aug 18, 2016 20:15

Head and Neck Cancers by Alexandros G. Sfakianakis

Voice and aging: clinical, endoscopic and acoustic investigation

Abstract Vocal symptoms are frequent in the elderly and are consequences of structural changes in the larynx that occur with aging. Objective to identify the voice alterations in elderly patients attending a voice clinic. Methods elderly patients of both genders were divided...

Thu Aug 18, 2016 20:15

Head and Neck Cancers by Alexandros G. Sfakianakis

Quality indicators of integrated care for patients with head and neck cancer

Abstract Objectives Oncological care is very complex, and delivery of integrated care with optimal alignment and collaboration of several disciplines is crucial. To monitor and effectively improve high-quality integrated oncological care, a dashboard of valid and reliable quality indicators (QIs)...

Thu Aug 18, 2016 20:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma

Regenerating gene (REG) family is composed of antiapoptotic factors and growth factors that affect epithelial cells within the digestive system. Regenerating gene-I has been studied in different cancers. Howev... http://ift.tt/2bqqJ6Q

Thu Aug 18, 2016 20:00

Head and Neck Cancers by Alexandros G. Sfakianakis

“A principal component analysis (PCA) how pneumatization and edentulism contribute to maxillary atrophy”

Abstract Objective The aim of this retrospective cohort study was to investigate the role of sinus pneumatization and residual ridge resorption in maxillary bone loss in 400 computed tomography (CT) scans. Materials and Methods In 200 dentate and 200 edentulous patients both sinuses were...

Thu Aug 18, 2016 20:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Genetic variants of 20q12 contributed to non-syndromic orofacial clefts susceptibility

Abstract Objective Previous genome-wide association studies (GWAS) identified a region near MAFB at chr20q12 associated with non-syndromic orofacial clefts (NSOC) susceptibility. However, whether other SNPs in this area could independently contribute to non-syndromic orofacial clefts in Chinese...

Thu Aug 18, 2016 20:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Intra-arterial versus intravenous abciximab therapy for thromboembolic complications of neuroendovascular procedures: case review and meta-analysis

Background Abciximab is used to treat thromboembolic complications of neuroendovascular procedures, but outcomes of treatment are not well defined. Objective To examine the angiographic and clinical outcomes based on route of abciximab administration and degree of vessel recanalization. Materials...

Thu Aug 18, 2016 19:45

Head and Neck Cancers by Alexandros G. Sfakianakis

The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain

Abstract Parkinson's Disease (PD) is the second most common neurodegenerative disease worldwide, affecting 1 % of the population over 65 years of age. Dopaminergic cell death in the substantia nigra and accumulation of Lewy bodies are the defining neuropathological hallmarks of the disease. Neuronal...

Thu Aug 18, 2016 19:45

Head and Neck Cancers by Alexandros G. Sfakianakis

Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review

Publication date: Available online 18 August 2016Source:Journal of Cranio-Maxillofacial Surgery Author(s): Markus Troeltzsch, Matthias Troeltzsch, Philipp Kauffmann, Rudolph Gruber, Phillipp Brockmeyer, Norman Moser, Anna Rau, Henning Schliephake PurposeTo evaluate the efficacy of grafting materials...

Thu Aug 18, 2016 19:45

Head and Neck Cancers by Alexandros G. Sfakianakis

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics

Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades. http://ift.tt/2b25C6k

Thu Aug 18, 2016 19:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Functional assessment of tyrosinase variants identified in individuals with albinism is essential for unequivocal determination of genotype to phenotype correlation

Abstract Background Oculocutaneous albinism type 1 (OCA1), caused by pathogenic variations in the tyrosinase gene (TYR), is the most frequent and severe form of hypopigmentary disorders worldwide. While OCA1A manifests as a complete loss of melanin pigment, patients with OCA1B show residual pigmentation...

Thu Aug 18, 2016 19:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

Abstract Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. Due to the limited success of available treatments, AD patients are...

Thu Aug 18, 2016 19:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Low levels of plasma galanin in obese subjects with hypertension

Abstract Background Obesity is strongly linked to increased blood pressure, which increases the risk of cardiovascular diseases. To our knowledge, little literature reported the information about galanin levels in obese individuals with hypertension. Therefore, the aim of this study was to investigate...

Thu Aug 18, 2016 19:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects

This case series describes outcomes for patients with medial canthal defects managed with lateral rotational and glabellar surgical flaps and provides a surgical procedure video illustrating the technique. http://ift.tt/2bLAMVQ

Thu Aug 18, 2016 19:16

Cancer

Vedolizumab: a novel treatment for ipilimumab-induced colitis

Use of the immune checkpoint inhibitors, ipilimumab and nivolumab, has revolutionised treatment in patients with metastatic melanoma. However, these drugs can cause an autoimmune enterocolitis, with diarrhoea as the presenting symptom. This is conventionally managed by prompt institution of corticosteroid...

Thu Aug 18, 2016 19:16

Cancer

Melanoma and the Microenvironment — Age Matters

Advancing age is a risk factor for cancer, and there is no doubt that the accumulation of DNA damage over time contributes to the correlation of age with cancer risk: an increase in the number of oncogenic mutations in precancerous cells increases the odds of cellular transformation. In addition,… http://ift.tt/2bKOTdG

Thu Aug 18, 2016 19:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Multicatheter interstitial brachytherapy versus intensity modulated external beam therapy for accelerated partial breast irradiation: A comparative treatment planning study with respect to dosimetry of organs at risk

Publication date: Available online 17 August 2016Source:Radiotherapy and Oncology Author(s): Tibor Major, Gábor Stelczer, Csilla Pesznyák, Norbert Mészáros, Csaba Polgár ObjectiveTo dosimetrically compare multicatheter interstitial brachytherapy (MIBT) and intensity modulated radiotherapy (IMRT)...

Thu Aug 18, 2016 19:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours

Publication date: Available online 17 August 2016Source:Radiotherapy and Oncology Author(s): Christina Jentsch, Ralf Bergmann, Kerstin Brüchner, Birgit Mosch, Ala Yaromina, Mechthild Krause, Daniel Zips, Esther G.C. Troost, Steffen Löck, Jörg Kotzerke, Jörg Steinbach, Howard Thames, Michael Baumann,...

Thu Aug 18, 2016 19:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Decreasing the under-notification of anaphylaxis deaths in brazil through the international classification of diseases (ICD)-11 revision

Abstract Background In 2012, an analysis of the Brazilian mortality database demonstrated under-notification of anaphylaxis deaths due, at least in part, to difficult coding under the International Classification of Diseases (ICD)-10. This work triggered a cascade of strategic international actions...

Thu Aug 18, 2016 19:00

Head and Neck Cancers by Alexandros G. Sfakianakis

Professional dental prophylaxis increases salivary cortisol in children with dental behavioural management problems: a longitudinal study

Abstract Background Dental procedures may cause stress and increase the salivary cortisol levels. It is important to known if apparently simple procedures such as professional dental prophylaxis at low speed (DP) are stressful for children with dental behaviour management problems (DBMP) to help with...

Thu Aug 18, 2016 18:40

Head and Neck Cancers by Alexandros G. Sfakianakis

Prevalence of early childhood caries and enamel defects in four and five-year old Qatari preschool children

Abstract Background Dental caries is the most prevalent chronic disease in early childhood in most communities worldwide. Several studies conducted in the Gulf Cooperation Council countries have documented a high prevalence of early childhood caries (ECC). To date, no studies have been conducted in...

Thu Aug 18, 2016 18:40

Head and Neck Cancers by Alexandros G. Sfakianakis

Identifying the public's concerns and the Centers for Disease Control and Prevention's reactions during a health crisis: An analysis of a Zika live Twitter chat

Publication date: Available online 17 August 2016Source:American Journal of Infection Control Author(s): Elizabeth M. Glowacki, Allison J. Lazard, Gary B. Wilcox, Michael Mackert, Jay M. Bernhardt The arrival of the Zika virus in the United States caused much concern among the public because of its...

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Biological accidents at work among resident physicians in specialist training at Bari University Hospital, Italy

Publication date: Available online 17 August 2016Source:American Journal of Infection Control Author(s): Antonella Basso, Rosaria Serra, Ignazio Drago, Leonardo Soleo, Piero Lovreglio The phenomenon of accidents at work was investigated among the resident physicians of the School of Medicine, Bari...

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Making change easy: A peer-to-peer guide on transitioning to new hand hygiene products

Publication date: Available online 17 August 2016Source:American Journal of Infection Control Author(s): Chingiz M. Amirov, Heather L. Candon, Latha Jacob This report summarizes our experiences planning and implementing the transition to a new commercial line of hand hygiene products and their dispensing...

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Vertical scanning interferometry: A new method to quantify re-/de-mineralization dynamics of dental enamel

Publication date: Available online 9 August 2016Source:Dental Materials Author(s): Isabella Pignatelli, Aditya Kumar, Kumar Shah, Magdalena Balonis, Mathieu Bauchy, Benjamin Wu, Gaurav Sant ObjectiveRemineralization and demineralization are processes that compete in the oral environment. At this...

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Disseminated intracranial xanthoma disseminatum: a rare case report and review of literature

Xanthoma disseminatum (XD) is a rare benign histiocytic proliferating disease of non-Langerhans cell origin, which is clinically mainly characterized by cutaneous or mucous lesions. Although XD is acknowledged... http://ift.tt/2aZkbwd

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Redifferentiation of High-Throughput Generated Fibrochondrocyte Micro-Aggregates: Impact of Low Oxygen Tension

In meniscus tissue engineering strategies, enhancing the matrix quality of the neomeniscal tissue is important. When the differentiated phenotype of fibrochondrocytes is lost, the quality of the matrix becomes compromised. The objective of this study was to produce uniform fibrochondrocyte micro-aggregates...

Thu Aug 18, 2016 18:20

Head and Neck Cancers by Alexandros G. Sfakianakis

Evaluation of Dying Vocal Fold Epithelial Cells by Ultrastructural Features and TUNEL Method

Cell death is a regulated mechanism of eliminating cells to maintain tissue homeostasis. This study described 2 methodological procedures for evaluating cell death in the epithelium of immobilized, approximated and vibrated vocal folds from 12 New Zealand white breeder rabbits. The gold standard technique...

Thu Aug 18, 2016 18:16

Cancer

Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology

A 59-year-old woman with right breast mass was diagnosed with invasive ductal carcinoma (IDC). Workup consisted of bilateral diagnostic mammogram and ultrasound (US); both showed a right breast mass with normal left breast. Core biopsy showed IDC with estrogen receptor negative (ER–)/progesterone receptor...

Thu Aug 18, 2016 18:16

Cancer

Native bivalvular endocarditis by Gemella haemolysans requiring venovenous extracorporeal membrane oxygenation

A 24-year-old otherwise healthy man presented with a 3-week history of malaise, headache, fever and rigors after he was treated with oral clindamycin for left parotitis and Gemella haemolysans bacteraemia. He developed G. haemolysans infective endocarditis, septic emboli and heart failure due to progressive...

Thu Aug 18, 2016 18:16

Cancer

Acute hypertension during ramucirumab infusion in two patients with advanced oesophagogastric cancer

Ramucirumab, a monoclonal antibody targeting the vascular endothelial growth factor (VEGF) pathway, in combination with paclitaxel is becoming part of standard second-line systemic therapy for advanced oesophagogastric cancer, based on the results of the REGARD and RAINBOW trials. Common well-known side...

08:55

Head and Neck Diseases

Mango leaf extract

 improves central pathology and cognitive impairment in a type 2 diabetes mouse model: Abstract Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common...

08:55

Head and Neck Diseases

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects: This case series describes outcomes for patients with medial canthal defects managed with lateral rotational and glabellar surgical flaps and provides a surgical procedure video illustrating the technique. Surgical Pearls | August 18, 2016...

08:55

Head and Neck Diseases

OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortex invasion could be an independent prognostic factor for patients

Does medullary vs. cortical invasion of the mandible affect prognosis in patients with oral squamous cell carcinoma? via Oral and Maxillofacial Surgery Publication date: Available online 18 August 2016Source:Journal of Oral and Maxillofacial Surgery Author(s): Chunjie Li,...

08:55

Head and Neck Diseases

Trigeminal Neuralgia

: A Retrospective Multicentre Study of 320 Asian Patients via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 17 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Hans Prakash Sathasivam,...

08:55

Head and Neck Diseases

Anaphylaxis

Decreasing the under-notification of anaphylaxis deaths in brazil through the international classification of diseases (ICD)-11 revision: Abstract Background In 2012, an analysis of the Brazilian mortality database demonstrated under-notification of anaphylaxis deaths due, at least in part, to difficult...

08:55

Head and Neck Diseases

Maternal active smoking and its risk of oral clefts

: a Meta-analysis via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 18 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Zhang Xuan, Yang Zhongpeng, Guo Yanjun, Dai Jiaqi, Zhu Yuchi, Shi...

08:55

Head and Neck Diseases

Diagnosis of oral lichen planus

: a position paper of the American Academy of Oral and Maxillofacial Pathology via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 3 Author(s):...

08:55

Head and Neck Diseases

The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis

: a systematic review and meta-analysis via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Jun Ju, Yun Li, Juan Chai, Chao Ma, Qianwei Ni, Zhiyuan Shen, Jianhua Wei, Moyi Sun ObjectiveWe...

08:55

Head and Neck Diseases

Increasing zoledronic acid concentrations,Early changes of the mandible in bisphosphonate-treated patients

Computed tomographic assessment of early changes of the mandible in bisphosphonate-treated patients via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume...

08:51

Head and Neck Diseases

No preventive effect on the development of allergic disease of the supplementation of ω3 polyunsaturated fatty acids, vitamins or minerals has been demonstrated when administered to children and/or their mother during pregnancy or breastfeeding.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:51

Head and Neck Diseases

Essential fatty acids are precursors of LCP, the synthesis of which is achieved through sequential enzymatic reactions of chain elongation (elongase) and desaturation (desaturase). The enzymes involved in the reactions of elongation and desaturation of these fatty acids are common to the two biosynthetic pathways (ω-3 and ω-6 series) and display a “competing for substrate” mechanism (Fig. 1). Eicosapentaenoic acid (EPA, C20: 5 ω-3) and docosahexaenoic acid (DHA, C22: 6 ω-3) are derived from acid

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:51

Head and Neck Diseases

The “classical” Th1/Th2 dichotomy and the Th17 line. The classic paradigm of the Th1/Th2 dichotomy has been made obsolete by the discovery of other cell lines. There are CD4 + T-helper cells expressing interleukin 17 (IL-17) and numerous categories of regulatory T cells (Treg) able to control effector T-cell responses have been described. While, strictly speaking, Tregs cells originate directly from thymic precursors, inducible Treg cells (iTreg) cells and Tr1 cells Th3 differ from precursors of

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:51

Head and Neck Diseases

Definition of wheezing according to the definitions of the European Respiratory Society [107] Temporal pattern of wheezing Episodic (viral) Wheezing during discrete periods of time, often in association with clinical evidence of viral cold, in the absence of wheezing in the inter-critical periods Multiple-trigger Wheezing with exacerbations over time, but also symptoms during periods between one episode and the other Duration of wheezing Transitory Symptoms that begin before 3 years and disappear

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Risk factors for the development of asthma (modified Asthma Predictive Index or API) for children with wheezing (modified from reference [110]). ≥4 episodes wheezing last year associated with: One major criterion: •One parent with asthma •Atopic dermatitis •Sensitisation to inhalant allergen or Two minor criteria: •Sensitisation to foods •Wheezing outside of infective episode •Eosinophilia (>4 %) A positive API index is associated with an increased probability of developing asthma between

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Early entry into the community cannot be considered a risk factor for the development of allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Early community exposure is not recommended to prevent the development of allergy

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

The existence of a relationship between latitude and its consequent degree of ultraviolet radiation exposure, vitamin D levels and the prevalence and severity of allergic diseases, the data of observational studies are encouraging, but controversial and the only available RCT fails to show an effect on allergic disease prevalence. The use of vitamin D supplementation for the primary prevention of allergic diseases remains an attractive topic of study, but current knowledge and available evidence

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Favourable effects of the administration of probiotics to breast- or formula-fed infants remain unclear when probiotics were not supplemented pre- or post-natally to their mothers. No administration modality exerts a preventive effect on asthma, rhinitis or prevents allergies. The safety profile is excellent, and significant adverse events in the treated groups were not found in any revised literature. Supplementation of probiotics to prevent allergic diseases cannot be recommended on the basis

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Evidence of recommendation for anti-mite measures Action on Type of intervention Level recommendation Facilitating factors Hygrometer Strong Dehumidifier Strong Central air conditioner None Allergenic source Dry Strong Acaricides Not recommended Freezing None Reservoir HEPA vacuum cleaners Strong Pillowcases, mattress Strong Pillowcases, pillow Strong Kit for quantitative evaluation Poor Denaturing agents Not recommended

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Recommendations for action to reduce mite allergen exposure. - Reduce the level of relative humidity in the house, keeping it at around 50 %. Use hygrometers and, possibly, a dehumidifier; - Use pillow and mattress covers and cushion covers made of fabric labelled “antimite”; - Eliminate allergen sources/reservoirs such as carpets, rugs, curtains, stuffed animals; - Hoover periodically with a vacuum-cleaner that can retain allergen in a HEPA filter; - A multifaceted approach that includes all

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Limited exposure to mite allergen improves the clinical status of sensitised children with respiratory or skin disease (atopic dermatitis). Recommendation Primary prevention of mite sensitisation is possible only through a comprehensive environmental monitoring strategy that must be assessed on a case by case basis and discussed in detail with the family.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Recommendation : In Western countries, children and adolescents spend most of their time in indoors: all interventions designed to reduce exposure to risk factors as much as possible should include tobacco smoke and indoor allergens (house dust mites, moulds and dog and cat epithelia in particular) represent an important opportunity for prevention.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Cigarette smoking is the main source of indoor air pollution. The harmful effects of smoking are mediated by irritant, mutagenic and immunological mechanisms which promote the development of many diseases. It is essential to be aware of smoke-related diseases and to promote a smoke-free environment for children.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

The association between exposure to smoking in childhood and risk of atopic sensitisation has been extensively studied, but the literature offers no consensus on this topic. However, the severity of smoke-related diseases suggest recommending absolute avoidance of exposure to second-hand smoke, regardless of the possibility that smoking may promote allergic sensitisation.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

08:50

Head and Neck Diseases

Prevention of food and airway allergy

: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades. Giuseppe di Mauro†, Roberto Bernardini†,...

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Head and Neck Diseases

Asthma and allergic rhinitis are strongly correlated with exposure to mould during the first year of life in children and adolescents. Prevention for exposure to mould has been demonstrated to be important in preventing allergic sensitisation. Avoidance of allergen exposure is crucial for children with documented mould allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics by Giuseppe di Mauro, Roberto Bernardini, Salvatore Barberi, Annalisa Capuano, Antonio Correra,...

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Head and Neck

Are TSH normal reference ranges adequate for pregnant women?

Are TSH normal reference ranges adequate for pregnant women? Arch Endocrinol Metab. 2016 Aug;60(4):303-306 Authors: Maciel LM PMID: 27533612 [PubMed - as supplied by publisher] } http://ift.tt/2bN5mhM http://ift.tt/2b37wUi http://ift.tt/2b397th http://ift.tt/2bFUQYk

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Head and Neck

Dealing with diabetes and pregnancy following bariatric surgery: a double-edged sword?

Dealing with diabetes and pregnancy following bariatric surgery: a double-edged sword? Arch Endocrinol Metab. 2016 Aug;60(4):299-302 Authors: Mancini MC PMID: 27533611 [PubMed - as supplied by publisher] } http://ift.tt/2bjM1Sm http://ift.tt/2b4Ov75 http://ift.tt/2b4QbO1 http://ift.tt/2bxmAuN

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Head and Neck

Erratum.

Erratum. Arch Endocrinol Metab. 2016 Aug;60(4):407 Authors: Abstract [This corrects the article doi: 10.1590/2359-3997000000144]. PMID: 27533618 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/2b35aox via IFTTT http://ift.tt/2bh7hsE...

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Head and Neck

Low carbohydrate high fat diets: when models do not match reality.

Low carbohydrate high fat diets: when models do not match reality. Arch Endocrinol Metab. 2016 Aug;60(4):405-406 Authors: Caminhotto RO, Lima FB PMID: 27533617 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/2b4M58t via IFTTT http://ift.tt/2b5qAl7...

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Head and Neck

Thyroid nodules with highly suspicious ultrasonographic features, but with benign cytology on two occasions: is malignancy still possible?

Thyroid nodules with highly suspicious ultrasonographic features, but with benign cytology on two occasions: is malignancy still possible? Arch Endocrinol Metab. 2016 Aug;60(4):402-404 Authors: Rosário PW, Calsolari MR Abstract Objective: There is no information about the frequency of malignancy...

04:14

Head and Neck

Genetics of osteoporosis: searching for candidate genes for bone fragility.

Genetics of osteoporosis: searching for candidate genes for bone fragility. Arch Endocrinol Metab. 2016 Aug;60(4):391-401 Authors: Rocha-Braz MG, Ferraz-de-Souza B Abstract The pathogenesis of osteoporosis, a common disease with great morbidity and mortality, comprises environmental and genetic...

04:14

Head and Neck

A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism.

A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism. Arch Endocrinol Metab. 2016 Aug;60(4):374-390 Authors: Vieira L, Boguszewski CL, Araújo LA, Bronstein...

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Head and Neck

Increasing diagnostic effectiveness of thyroid nodule evaluation by implementation of cell block preparation in routine US-FNA analysis.

Increasing diagnostic effectiveness of thyroid nodule evaluation by implementation of cell block preparation in routine US-FNA analysis. Arch Endocrinol Metab. 2016 Aug;60(4):367-373 Authors: Cristo AP, Goldstein HF, Faccin CS, Maia AL, Graudenz MS Abstract Objective: Ultrasound-guided fine-needle...

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Anatomy Pathology

Cutaneous Mantle Cell Lymphoma: A Clinicopathologic Review of 10 Cases

Abstract Cutaneous MCL is exceedingly rare, almost always occurring as a dissemination of systemic MCL. To date, only 32 cases have been described. We report a series of 10 cases of MCL in the skin, and provide a comprehensive clinico-pathologic review with clinical follow-up. Our cases occurred in...

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Thyroid Disorders by Alexandros G.Sfakianakis

Medullary Thyroid Carcinoma: Recent Advances Including MicroRNA Expression

Abstract Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumor arising from the C cells in the thyroid and accounts for about 5 % of all thyroid cancers. MTC exhibits more aggressive behavior than follicular tumors, with the majority of cases presenting with lymph node metastasis. It...

08:54

Ενδοκρινολογία

Germline mutations and genotype-phenotype correlation in Asian Indian patients with pheochromocytoma and paraganglioma

Background Genetic aetiology of pheochromocytoma (PCC) and paraganglioma (PGL) is increasingly being studied; however, Asian Indian data on this aspect are scarce. Objective To study the prevalence of germline mutations and genotype–phenotype correlation in Asian Indian PCC/PGL patients. Design...

08:54

Ενδοκρινολογία

The cardiovascular system in familial hypocalciuric hypercalcemia: a cross-sectional study on physiological effects of inactivating variants in the calcium-sensing receptor gene

Objective Loss-of-function variants in the gene encoding the calcium-sensing receptor (CASR) result in familial hypocalciuric hypercalcemia (FHH), causing hypercalcemia with high normal or elevated parathyroid hormone levels. The CASR may also influence electrolyte and water homeostasis. It is unknown...

08:54

Ενδοκρινολογία

MANAGEMENT OF ENDOCRINE DISEASE: Pituitary 'incidentaloma: neuroradiological assessment and differential diagnosis

Pituitary incidentalomas are a by-product of modern imaging technology. The term 'incidentaloma' is neither a distinct diagnosis nor a pathological entity. Rather, it is a collective designation for different entities that are discovered fortuitously, requiring a working diagnosis based on the input...

08:49

Υπνική Άπνοια και Διαταραχές Ύπνου

Don’t Forget About The ASBA Study Club And Diplomate Exam/Review Coming In One Month!

The American Sleep and Breathing Academy is an organization dedicated to enriching our members' knowledge and skill in the treatment of sleep disordered breathing. Our goal is to provide current evidence based information to our members and enable them to provide optimal treatment for their patients....

08:49

Υπνική Άπνοια και Διαταραχές Ύπνου

Join Us In Dallas For The Most Turn-key Intro. To Sleep 101 Course In The Country Through The American Sleep And Breathing Academy

Many dentists start out on an arduous road with road blocks everywhere in dental sleep medicine. It doesn't have to be like that. When you sign up for vendor sponsored courses they try to sell you products which are often old, obsolete and not beneficial at all to the success of the practice. How many...

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Medicine by Sfakianakis G. Alexandros

Careers advice: do we leave it too late?

Linked Article: Heede et al. Br J Dermatol 2016; 175:287–295. http://ift.tt/2bf7MU5

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Medicine by Sfakianakis G. Alexandros

Phalangeal bone anomalies in the European common toad Bufo bufo from polluted environments

Abstract Every spring, many of amphibians are killed by motor vehicles on roads. These road-killed animals can be used as valuable material for non-invasive studies showing the effect of environmental pollution on amphibian populations. The aims of our research were to check whether the phalanges of...

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Medicine by Sfakianakis G. Alexandros

Pressure-regulated volume control vs. volume control ventilation in healthy and injured rabbit lung: An experimental study.

BACKGROUND: It is not well understood how different ventilation modes affect the regional distribution of ventilation, particularly within the injured lung. OBJECTIVES: We compared respiratory mechanics, lung aeration and regional specific ventilation (sV) distributions in healthy and surfactant-depleted...

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Medicine by Sfakianakis G. Alexandros

A Complication Analysis of 2 Acellular Dermal Matrices in Prosthetic-based Breast Reconstruction

Background: Acellular dermal matrices (ADM) are now routine in postmastectomy prosthetic-based breast reconstruction. The goal of the current study was to compare the complications of 2 ADM products—AlloDerm and Cortiva. Methods: A retrospective analysis of prosthetic-based breast reconstruction in Atlanta,...

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Medicine by Sfakianakis G. Alexandros

Psychological sequelae of toxic epidermal necrolysis: further insights

http://ift.tt/2boLZLi

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Medicine by Sfakianakis G. Alexandros

In ovo toxico-teratological effects of aluminum on embryonic chick heart and vascularization

Abstract In spite of extensive research and persistent arguments, the mechanism of aluminum (Al) toxicity is still obscure. It is firmly established that aluminum is a potent neurotoxicant. So, the aim based on is aluminum damage chicken heart, as well as the vitelline circulation. In the first 3 days...

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Medicine by Sfakianakis G. Alexandros

Adsorption of arsenic from water and its recovery as a highly active photocatalyst

Abstract The contamination of water with arsenic has aroused concern around the world due to its toxic effects. Thus, the development of low-cost technologies for treating water contaminated with toxic metals is highly advisable. Adsorption is an attractive technology for purification of contaminated...

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Medicine by Sfakianakis G. Alexandros

Impact of an outright ban on the availability of commercial tanning services in Victoria, Australia

Summary Australian states have introduced an outright ban on commercial artificial tanning sunbeds. This was based on evidence from systematic reviews affirming a strong association between tanning bed use and increased risk of melanoma. The implementation of the ban provides an opportunity to assess...

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Medicine by Sfakianakis G. Alexandros

Predictors of drug survival for tumour necrosis factor-α and interleukin 12/23 antagonists in psoriasis

Linked Article: Zweegers et al. Br J Dermatol 2016; 175:340–347. http://ift.tt/2b3pcj9

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Medicine by Sfakianakis G. Alexandros

Occurrence of illicit drugs and selected pharmaceuticals in Slovak municipal wastewater

Abstract We analyzed illicit drugs and their metabolites and pharmaceuticals in wastewater from 15 selected wastewater treatment plants (WWTPs) in Slovakia. Our results indicate that methamphetamine is one of the most commonly used illegal drugs in all the regions of Slovakia monitored in this study....

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Medicine by Sfakianakis G. Alexandros

TOX – what role does it play in cutaneous lymphomas?

Linked Article: Schrader et al. Br J Dermatol 2016; 175:382–386. http://ift.tt/2boM5Tc

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Medicine by Sfakianakis G. Alexandros

Hidradenitis suppurativa: development of outcome measure instruments

Linked Article: Ingram et al. Br J Dermatol 2016; 175: 263–272. http://ift.tt/2boNuZI

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Medicine by Sfakianakis G. Alexandros

Brodalumab established as an effective interleukin-17 receptor antagonist in psoriasis

Linked Article: Papp et al. Br J Dermatol 2016; 175:273–286. http://ift.tt/2boMm8I

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Medicine by Sfakianakis G. Alexandros

Homogeneous photocatalytic oxidation of UV filter para -aminobenzoic acid in aqueous solutions

Abstract The presence of personal care product (PCP) residues in the aquatic environment is an emerging issue due to their uncontrolled release through graywater; for this reason, efforts are being made to develop methods to inactivate or eliminate this class of substances in the environment. In this...

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Medicine by Sfakianakis G. Alexandros

C-MAC videolaryngoscope compared with direct laryngoscopy for rapid sequence intubation in an emergency department: A randomised clinical trial.

BACKGROUND: Airway management in the emergency room can be challenging when patients suffer from life-threatening conditions. Mental stress, ignorance of the patient's medical history, potential cervical injury or immobilisation and the presence of vomit and/or blood may also contribute to a difficult...

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Medicine by Sfakianakis G. Alexandros

Targeting KIR3DL2 in primary cutaneous anaplastic large cell lymphomas

Linked Article: Battistella et al. Br J Dermatol 2016; 175:325–333. http://ift.tt/2bAidQk

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Medicine by Sfakianakis G. Alexandros

Plain language summaries in Simplified Chinese

Linked Article: Heede et al. Br J Dermatol 2016; 175:287–295. Linked Article: Papp et al. Br J Dermatol 2016; 175:273–286. Linked Article: Solé et al. Br J Dermatol 2016; 175:302–313. Linked Article: Inoue et al. Br J Dermatol 2016; 175:334–339. Linked Article: Zweegers et al. Br...

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Medicine by Sfakianakis G. Alexandros

Reflectance confocal microscopy: new micromorphological insights into inflammatory skin diseases

http://ift.tt/2boMaWU

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Medicine by Sfakianakis G. Alexandros

Biota monitoring and the Water Framework Directive—can normalization overcome shortcomings in sampling strategies?

Abstract We compare the results of different monitoring programs regarding spatial and temporal trends of priority hazardous substances of the European Water Framework Directive (WFD). Fish monitoring data for hexachlorobenzene (HCB), mercury (Hg), and perfluorooctane sulfonic acid (PFOS) sampled in...

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Medicine by Sfakianakis G. Alexandros

Editor's Choice

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Medicine by Sfakianakis G. Alexandros

Plain language summaries

Linked Article: Heede et al. Br J Dermatol 2016; 175:287–295. Linked Article: Papp et al. Br J Dermatol 2016; 175:273–286. Linked Article: Solé et al. Br J Dermatol 2016; 175:302–313. Linked Article: Inoue et al. Br J Dermatol 2016; 175:334–339. Linked Article: Zweegers et al. Br...

08:45

Medicine by Sfakianakis G. Alexandros

The evolving regulatory role of ubiquitin-editing enzyme A20 in psoriasis during calcipotriol treatment

Linked Article: Liu et al. Br J Dermatol 2016; 175:314–324. http://ift.tt/2boM9T5

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Medicine by Sfakianakis G. Alexandros

Differential effects on adiposity and serum marker of bone formation by post-weaning exposure to methylparaben and butylparaben

Abstract Paraben esters and their salts are widely used as preservatives in cosmetics, personal care products, pharmaceuticals, and foods. We and others have reported that parabens promote adipogenesis in vitro. Here, we investigated the effects of post-weaning exposure to parabens (methylparaben and...

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Medicine by Sfakianakis G. Alexandros

Substrate- and plant-mediated removal of citrate-coated silver nanoparticles in constructed wetlands

Abstract The growing production and commercial application of engineered nanoparticles (ENPs), such as Ag, CeO2, and TiO2 nanoparticles, induce a risk to the environment as ENPs are released during their use. The comprehensive assessment of the environmental risk that the ENPs pose involves understanding...

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Medicine by Sfakianakis G. Alexandros

News and Notices

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Medicine by Sfakianakis G. Alexandros

Evaluation of Dyspnea Outcomes After Endoscopic Airway Surgery for Laryngotracheal Stenosis.

Evaluation of Dyspnea Outcomes After Endoscopic Airway Surgery for Laryngotracheal Stenosis. JAMA Otolaryngol Head Neck Surg. 2016 Aug 11; Authors: Samad I, Akst L, Karatayli-Özgürsoy S, Teets K, Simpson M, Sharma A, Best SR, Hillel AT Abstract Importance: Endoscopic airway surgery is a frequently...

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Medicine by Sfakianakis G. Alexandros

Treatment of Benign Tracheal Stenosis Using Endoluminal Spray Cryotherapy.

Treatment of Benign Tracheal Stenosis Using Endoluminal Spray Cryotherapy. JAMA Otolaryngol Head Neck Surg. 2016 Aug 11; Authors: Bhora FY, Ayub A, Forleiter CM, Huang CY, Alshehri K, Rehmani S, Al-Ayoubi AM, Raad W, Lebovics RS Abstract Importance: Tracheal stenosis is a debilitating disorder...

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Medicine by Sfakianakis G. Alexandros

Association Between Computed Tomographic Scan and Timing and Treatment of Peritonsillar Abscess in Children.

Association Between Computed Tomographic Scan and Timing and Treatment of Peritonsillar Abscess in Children. JAMA Otolaryngol Head Neck Surg. 2016 Aug 11; Authors: Grant MC, Guarisco JL Abstract Importance: There is not a consensus on the best diagnostic algorithm for children with a potential...

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Medicine by Sfakianakis G. Alexandros

Baha implant as a hearing solution for single-sided deafness after retrosigmoid approach for the vestibular schwannoma: audiological results.

Baha implant as a hearing solution for single-sided deafness after retrosigmoid approach for the vestibular schwannoma: audiological results. Eur Arch Otorhinolaryngol. 2016 Aug 16; Authors: Bouček J, Vokřál J, Černý L, Chovanec M, Zábrodský M, Zvěřina E, Betka J, Skřivan J Abstract Skull base...

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Medicine by Sfakianakis G. Alexandros

Vocal Fatigue Symptoms and Laryngeal Status in Relation to Vocal Activity Limitation and Participation Restriction

The study aims to investigate the vocal fatigue symptoms and laryngeal status in relation to vocal activity limitations and vocal participation restrictions. http://ift.tt/2bf6IzC

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Medicine by Sfakianakis G. Alexandros

Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review

To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations. http://ift.tt/2b1iXf5

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Medicine by Sfakianakis G. Alexandros

Influence of Self-generated Anchors on the Voice Handicap Index-10 (VHI-10)

The aim of this research is to study whether the presentation of the Voice Handicap Index-10 questionnaire administered at the beginning of the treatment impinged on the results of the responses from the end of the treatment. http://ift.tt/2b3n62J

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Medicine by Sfakianakis G. Alexandros

Adenoid cystic carcinoma: emerging role of translocations and gene fusions.

Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016 Aug 14; Authors: Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M Abstract Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis,...

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Medicine by Sfakianakis G. Alexandros

MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma.

MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma. Oncotarget. 2016 Aug 13; Authors: Li JZ, Gao W, Lei WB, Zhao J, Chan JY, Wei WI, Ho WK, Wong TS Abstract MicroRNA controls cancer invasion by governing the expression...

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Medicine by Sfakianakis G. Alexandros

Association of nonsteroidal anti-inflammatory drugs and aspirin use and the risk of head and neck cancers: a meta-analysis of observational studies.

Association of nonsteroidal anti-inflammatory drugs and aspirin use and the risk of head and neck cancers: a meta-analysis of observational studies. Oncotarget. 2016 Aug 12; Authors: Tang L, Hu H, Liu H, Jian C, Wang H, Huang J Abstract PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs), including...

08:44

Medicine by Sfakianakis G. Alexandros

Regenerative Medicine in Facial Plastic and Reconstructive Surgery: A Review.

Regenerative Medicine in Facial Plastic and Reconstructive Surgery: A Review. JAMA Facial Plast Surg. 2016 Aug 11; Authors: Miller MQ, Dighe A, Cui Q, Park SS, Christophel JJ Abstract The field of regenerative medicine aims at enhancing tissue healing and regeneration through the exogenous addition...

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Medicine by Sfakianakis G. Alexandros

Rare Infratentorial and Supratentorial Localization of Juvenile Angiofibroma: A Case Report.

Rare Infratentorial and Supratentorial Localization of Juvenile Angiofibroma: A Case Report. Pediatr Neurosurg. 2016 Aug 18; Authors: Pašalić I, Trninić I, Nemir J, Jednačak H, Žarković K, Mrak G Abstract Angiofibromas are rare tumors of the head and neck that mostly occur in the sphenopalatine...

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Medicine by Sfakianakis G. Alexandros

Case study: Head orientation and neck electromyography for cursor control in persons with high cervical tetraplegia.

Case study: Head orientation and neck electromyography for cursor control in persons with high cervical tetraplegia. J Rehabil Res Dev. 2016;53(4):519-530 Authors: Williams MR, Kirsch RF Abstract We evaluated the ability of an individual with a high cervical spinal cord injury (SCI) to control...

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Medicine by Sfakianakis G. Alexandros

Extracranial head and neck neurogenic tumors: report of 47 cases.

Extracranial head and neck neurogenic tumors: report of 47 cases. Tunis Med. 2016 Feb;94(2):135-139 Authors: Ben Gamra O, Romdhane N, Khamassi K, Nacef I, Abid W, Chammakhi C, Hariga I, Mbarek C Abstract Extracranial head and neck neurogenic tumors are rare and usually revealed by histological...

09:08

OtoRhinoLaryngology

No preventive effect on the development of allergic disease of the supplementation of ω3 polyunsaturated fatty acids, vitamins or minerals has been demonstrated when administered to children and/or their mother during pregnancy or breastfeeding.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Essential fatty acids are precursors of LCP, the synthesis of which is achieved through sequential enzymatic reactions of chain elongation (elongase) and desaturation (desaturase). The enzymes involved in the reactions of elongation and desaturation of these fatty acids are common to the two biosynthetic pathways (ω-3 and ω-6 series) and display a “competing for substrate” mechanism (Fig. 1). Eicosapentaenoic acid (EPA, C20: 5 ω-3) and docosahexaenoic acid (DHA, C22: 6 ω-3) are derived from acid α-linolenic acid and arachidonic acid (AA, C20: 4 ω-6). is derived from linoleic acid. Eicosapentaenoic acid (ω-3), docosahexaenoic acid (ω-3) and arachidonic acid (ω-6) have particular biological significance as fundamental components of cell membranes (especially in the brain and retina). They are precursors of eicosanoids, compounds which consist of 20 carbon atoms (from the Greek éikosi), and are highly bioactive, acting as intercellular mediators and/or locally-acting and controlling hormones. Arachidonic acid it is the predominant precursor, present in high concentrations in all membrane phospholipids. Three different enzyme systems oxidize AA: cyclooxygenase (with training prostaglandins and thromboxanes), lipoxygenase (with the production of leukotrienes) and cytochrome P450 monooxygenase (forming 19- and 20-HETE). The biological activities of eicosanoids are varied: for example, prostaglandin E2 (PGE2) acts on blood vessels, airways, the stomach, the kidneys, neutrophil function, lymphocytes and pain receptors. Even ω-3 fatty acids can be used for the synthesis of eicosanoids, which, however, have opposed characteristics from AA-derived eicosanoids, determining smooth muscle relaxation and vasodilatation (prostacyclins). For this reason, the mechanism of competition for substrate has a very precise meaning: ω-6 fatty acids, in fact, are much more abundant in nature and in the “Western” diet, but enzymatic chain processing favours ω-3 fatty acids when present. Long-chain polyunsaturated fatty acids are best known for their possible effects on the central nervous system as a component of cell membranes, but they are also associated with the modulation of immune responses as precursors of eicosanoids [90]. The “anti-inflammatory” effect of EPA and DHA (found in fish and, in particular, their oils) is based on a competitive mechanism: at the membrane level, these LCPUFA of the ω-3 series replace AA (from which highly inflammatory eicosanoids are derived) and determines decidedly bland inflammatory eicosanoid activities. The intake of fish oil would, therefore, exert a potentially anti-inflammatory effect. In contrast, the increased consumption of vegetable oils rich in ω-6 polyunsaturated fatty acids is one of the main dietary factors in the allergic epidemic [93, 94, 95].

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Definition of wheezing according to the definitions of the European Respiratory Society [107] Temporal pattern of wheezing Episodic (viral) Wheezing during discrete periods of time, often in association with clinical evidence of viral cold, in the absence of wheezing in the inter-critical periods Multiple-trigger Wheezing with exacerbations over time, but also symptoms during periods between one episode and the other Duration of wheezing Transitory Symptoms that begin before 3 years and disappeared (retrospectively) within 6 years; wheezing transition can be either episodic or multiple-triggered Persistent Symptoms that persisted (retrospectively) over 6 years; persistent wheezing can be either episodic or multiple-triggered Late-onset Symptoms begin after 3 years of age; either episodic or multiple-triggered

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Risk factors for the development of asthma (modified Asthma Predictive Index or API) for children with wheezing (modified from reference [110]). ≥4 episodes wheezing last year associated with: One major criterion: •One parent with asthma •Atopic dermatitis •Sensitisation to inhalant allergen or Two minor criteria: •Sensitisation to foods •Wheezing outside of infective episode •Eosinophilia (>4 %) A positive API index is associated with an increased probability of developing asthma between 6 and 13 years from 4- to 10-fold. More than 95 % of children with negative API score in the first 3 years of life do not develop asthma between 6 and 13 years.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

The “classical” Th1/Th2 dichotomy and the Th17 line. The classic paradigm of the Th1/Th2 dichotomy has been made obsolete by the discovery of other cell lines. There are CD4 + T-helper cells expressing interleukin 17 (IL-17) and numerous categories of regulatory T cells (Treg) able to control effector T-cell responses have been described. While, strictly speaking, Tregs cells originate directly from thymic precursors, inducible Treg cells (iTreg) cells and Tr1 cells Th3 differ from precursors of peripheral T-helper cells through the action of several cytokines such as TG F-β, IL-2 and retinoic acid (Fig. 1). Th17 cells play a role in the immune response to self and, along the two “classic” Th1 and Th2 cell lines and Treg, represent not only a key component of the innate immune response to infection, but also exert a pro-inflammatory effect and promote tissue damage in various chronic inflammatory diseases such as asthma [98]. Recent studies have confirmed a role of this cell line in the pathogenesis of asthma in children of school age [98, 99]. Other evidence for the hygiene hypothesis consisted in the observation of a reduced rate of allergies among children living in countries with low sanitary conditions and lower health education (associated with an increased incidence among immigrants from these countries in the West) or amid children who have contracted tuberculosis or measles, of an inverse correlation between risk of developing allergy and family educational level, as well as vaccination for measles or conditions conducive to infections, such as a large number of siblings and early age at first exposure to community contacts [97].

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Early entry into the community cannot be considered a risk factor for the development of allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Early community exposure is not recommended to prevent the development of allergy

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

The existence of a relationship between latitude and its consequent degree of ultraviolet radiation exposure, vitamin D levels and the prevalence and severity of allergic diseases, the data of observational studies are encouraging, but controversial and the only available RCT fails to show an effect on allergic disease prevalence. The use of vitamin D supplementation for the primary prevention of allergic diseases remains an attractive topic of study, but current knowledge and available evidence does not warrant its recommendation [129]. Several randomised controlled trials are underway and they will certainly inform future recommendations on the basis of more solid evidence. Recommendation . On basis of the available evidence, the use of vitamin D supplementation is not recommended for the primary prevention of allergic disease.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Limited exposure to mite allergen improves the clinical status of sensitised children with respiratory or skin disease (atopic dermatitis). Recommendation Primary prevention of mite sensitisation is possible only through a comprehensive environmental monitoring strategy that must be assessed on a case by case basis and discussed in detail with the family.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Favourable effects of the administration of probiotics to breast- or formula-fed infants remain unclear when probiotics were not supplemented pre- or post-natally to their mothers. No administration modality exerts a preventive effect on asthma, rhinitis or prevents allergies. The safety profile is excellent, and significant adverse events in the treated groups were not found in any revised literature. Supplementation of probiotics to prevent allergic diseases cannot be recommended on the basis of the available evidence. Encouraging data on a possible reduction in the risk of atopic dermatitis should be interpreted with great caution as 25 infants have to be treated to prevent a single case of dermatitis and several studies suffer from a high percentage of patients lost to follow-up. Recommendation : supplementation with probiotics The administration of probiotics for the prevention of asthma, rhinitis and food allergy cannot be recommended as available studies demonstrated their ineffectiveness in the literature. The administration of probiotics to the mother during pregnancy and/or after delivery, and in together with their child during the first 6 months of life, can be considered as an intervention for the prevention of atopic dermatitis, even in the infrequent cases in which the prevailing trigger is food, among children at risk. The effect is moderate but constant across studies available in the literature. Recommendation supplementation with prebiotics At the state of knowledge no recommendations of the use of prebiotics can be issued.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Evidence of recommendation for anti-mite measures Action on Type of intervention Level recommendation Facilitating factors Hygrometer Strong Dehumidifier Strong Central air conditioner None Allergenic source Dry Strong Acaricides Not recommended Freezing None Reservoir HEPA vacuum cleaners Strong Pillowcases, mattress Strong Pillowcases, pillow Strong Kit for quantitative evaluation Poor Denaturing agents Not recommended

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Recommendations for action to reduce mite allergen exposure. - Reduce the level of relative humidity in the house, keeping it at around 50 %. Use hygrometers and, possibly, a dehumidifier; - Use pillow and mattress covers and cushion covers made of fabric labelled “antimite”; - Eliminate allergen sources/reservoirs such as carpets, rugs, curtains, stuffed animals; - Hoover periodically with a vacuum-cleaner that can retain allergen in a HEPA filter; - A multifaceted approach that includes all the previously described measures is likely to be more effective and is thus recommended; - Measures targeted at the physical elimination of mites (washing at high temperatures > 60 ° C, freezing, drying) are theoretically effective and can be recommended but clinical trials are lacking that show their effectiveness; - The use of acaricides is not recommended (limited effectiveness and possible toxicity)

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

The association between exposure to smoking in childhood and risk of atopic sensitisation has been extensively studied, but the literature offers no consensus on this topic. However, the severity of smoke-related diseases suggest recommending absolute avoidance of exposure to second-hand smoke, regardless of the possibility that smoking may promote allergic sensitisation.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Recommendation : In Western countries, children and adolescents spend most of their time in indoors: all interventions designed to reduce exposure to risk factors as much as possible should include tobacco smoke and indoor allergens (house dust mites, moulds and dog and cat epithelia in particular) represent an important opportunity for prevention.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Cigarette smoking is the main source of indoor air pollution. The harmful effects of smoking are mediated by irritant, mutagenic and immunological mechanisms which promote the development of many diseases. It is essential to be aware of smoke-related diseases and to promote a smoke-free environment for children.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics: Allergic sensitization in children and allergic diseases arising therefrom are increasing for decades....

09:08

OtoRhinoLaryngology

Asthma and allergic rhinitis are strongly correlated with exposure to mould during the first year of life in children and adolescents. Prevention for exposure to mould has been demonstrated to be important in preventing allergic sensitisation. Avoidance of allergen exposure is crucial for children with documented mould allergy.

Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatricsby Giuseppe di Mauro, Roberto Bernardini, Salvatore Barberi, Annalisa Capuano, Antonio Correra, Gian...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Risk Factors and Cognitive Relevance of Cortical Cerebral Microinfarcts in Patients With Ischemic Stroke or Transient Ischemic Attack [Original Contribution]

Background and Purpose—It was recently demonstrated that cerebral microinfarcts (CMIs) can be detected in vivo using 3.0 tesla (T) magnetic resonance imaging. We investigated the prevalence, risk factors, and the longitudinal cognitive consequence of cortical CMIs on 3.0T magnetic resonance imaging,...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment [Brief Report]

Background and Purpose—Mild cognitive impairment (MCI) is common after stroke and associated with poor outcome. However, the mechanisms underlying poststroke MCI (PS-MCI) are insufficiently understood. We performed amyloid-β positron emission tomography (PET) in a prospective cohort of stroke survivors...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Medullary Thyroid Carcinoma: Recent Advances Including MicroRNA Expression

Abstract Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumor arising from the C cells in the thyroid and accounts for about 5 % of all thyroid cancers. MTC exhibits more aggressive behavior than follicular tumors, with the majority of cases presenting with lymph...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Safety and efficacy of fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia

Summary IntroductionLow-dose isotretinoin is used to reduce side effects albeit higher relapse. This study aimed to determine the efficacy and safety of fixed-dose 10 mg daily isotretinoin for the treatment of acne. MethodsThis prospective study was performed between 2011 and 2015. All 150 patients...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

The pivotal role of mammalian target of rapamycin inhibition in the treatment of patients with neuroendocrine tumors

Abstract Significant advances have been made toward understanding the biology of neuroendocrine tumors (NET) in terms of defining prognosis and improving clinical management; however, many unmet needs remain. The treatment landscape for NET has evolved, with the approval of the targeted agents everolimus...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Truth-Telling in Taiwanese Cancer Care: Patients’ and Families’ Preferences and their Experiences of Doctors’ Practices

Abstract ObjectiveDespite the significant role played by cancer patients’ families in medical decision-making in Asian countries, inconsistencies have hitherto not been evaluated between patients’ and families’ preferences and doctors’ actual practices with regard to cancer truth telling. MethodsFor...

08:58

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

The hedgehog pathway in triple-negative breast cancer

Abstract Treatment of triple-negative breast cancer (TNBC) remains challenging due to the underlying heterogeneity of this disease coupled with the lack of predictive biomarkers and effective targeted therapies. Intratumoral heterogeneity, particularly enrichment for breast cancer stem cell-like subpopulations,...

08:47

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao

In Vivo Generation of Neural Stem Cells Through Teratoma Formation

Stem Cells and Development , Vol. 0, No. 0. from #Stem Cell via xlomafota13 on Inoreader...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): Ashwini Kumar Giddam, Jennifer M Reiman, Mehfuz Zaman, Mariusz Skwarczynski, Istvan Toth, Michael F GoodAlthough attenuated malaria parasitized red blood cells (pRBCs) are promising vaccine candidates,...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Electric field-assisted formation of organically modified hydroxyapatite (ormoHAP) spheres in carboxymethylated gelatin gels

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): C. Heinemann, S. Heinemann, B. Kruppke, H. Worch, J. Thomas, H.P. Wiesmann, T. HankeA biomimetic strategy was developed in order to prepare organically modified hydroxyapatite (ormoHAP) with spherical...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Azo polymeric micelles designed for colon-targeted dimethyl fumarate delivery for colon cancer therapy

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): Zhen-Gang Ma, Rui Ma, Xiao-Lin Xiao, Yong-Hui Zhang, Xin-Zi Zhang, Nan Hu, Jin-Lai Gao, Yu-Feng Zheng, De-Li Dong, Zhi-Jie SunColon-targeted drug delivery and circumventing drug resistance are...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Natural myocardial ECM Patch Drives Cardiac Progenitor Based Restoration Even After Scarring

Publication date: Available online 18 August 2016Source:Acta Biomaterialia Author(s): Udi Sarig, Hadar Sarig, Elio de-Berardinis, Su-Yin Chaw, Evelyne B.V. Nguyen, Vaibavi S. Ramanujam, Vu D. Thang, Muthafar Al-Haddawi, Susan Liao, Dror Seliktar, Theodoros Kofidis, Freddy Y.C....

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Micropore-induced Capillarity Enhances Bone Distribution in vivo in Biphasic Calcium Phosphate Scaffolds

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): Laurence E. Rustom, Thomas Boudou, Siyu Lou, Isabelle Pignot-Paintrand, Brett W. Nemke, Yan Lu, Mark D. Markel, Catherine Picart, Amy J. Wagoner JohnsonThe increasing demand for bone repair solutions...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 – a possible regulatory role on extracellular matrix homeostasis

Publication date: Available online 18 August 2016Source:Acta Biomaterialia Author(s): Sandra Rother, Sergey A. Samsonov, Tommy Hofmann, Joanna Blaszkiewicz, Sebastian Köhling, Stephanie Moeller, Matthias Schnabelrauch, Jörg Rademann, Stefan Kalkhof, Martin von Bergen, M. Teresa...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Electrostatic flocking of chitosan fibres leads to highly porous, elastic and fully biodegradable anisotropic scaffolds

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): Elke Gossla, Robert Tonndorf, Anne Bernhardt, Martin Kirsten, Rolf-Dieter Hund, Dilibar Aibibu, Chokri Cherif, Michael GelinskyElectrostatic flocking – a common textile technology applied in industry...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Neural Tissue Engineering: Bioresponsive Nanoscaffolds using Engineered Self-Assembling Peptides

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): K.M. Koss, L.D. UnsworthRescuing or repairing neural tissues is of utmost importance to the patient’s quality of life after an injury. To remedy this, many novel biomaterials are being developed that are, ideally,...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Horn and horn core trabecular bone of bighorn sheep rams absorbs impact energy and reduces brain cavity accelerations during high impact ramming of the skull

Publication date: Available online 17 August 2016Source:Acta Biomaterialia Author(s): Aaron Drake, Tammy L. Haut Donahue, Mitchel Stansloski, Karen Fox, Benjamin B. Wheatley, Seth W. DonahueBighorn sheep (Ovis canadensis) routinely experience violent impacts to the head as part of intraspecific...

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation for Treating Low-Risk Papillary Thyroid Microcarcinoma: A Prospective Study

Thyroid , Vol. 0, No. 0. from Endocrinology via xlomafota13 on Inoreader http://ift.tt/2b89RiW

08:42

OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE

Unemployment Risk and Decreased Income Two and Four Years After Thyroid Cancer Diagnosis: A Population-Based Study

Thyroid , Vol. 0, No. 0. from Endocrinology via xlomafota13 on Inoreader http://ift.tt/2bNC6r0

08:37

OtoRhinoLaryngology

Mango leaf extract

 improves central pathology and cognitive impairment in a type 2 diabetes mouse model: AbstractEpidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer’s disease (AD) and vascular dementia (VaD), the most common causes...

08:37

OtoRhinoLaryngology

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects

Lateral Rotational–Glabellar Flaps for Medial Canthal Defects: This case series describes outcomes for patients with medial canthal defects managed with lateral rotational and glabellar surgical flaps and provides a surgical procedure video illustrating the technique.Surgical Pearls | August 18, 2016Combination...

08:37

OtoRhinoLaryngology

OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortex invasion could be an independent prognostic factor for patients

Does medullary vs. cortical invasion of the mandible affect prognosis in patients with oral squamous cell carcinoma?via Oral and Maxillofacial SurgeryPublication date: Available online 18 August 2016Source:Journal of Oral and Maxillofacial SurgeryAuthor(s): Chunjie Li, Jie Lin, Yi Men, Wenbin Yang, Fanglin...

08:37

OtoRhinoLaryngology

Trigeminal Neuralgia

: A Retrospective Multicentre Study of 320 Asian Patientsvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: Available online 17 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Hans Prakash Sathasivam, Sumairi Ismail, Abdul Rahim...

08:37

OtoRhinoLaryngology

Anaphylaxis

Decreasing the under-notification of anaphylaxis deaths in brazil through the international classification of diseases (ICD)-11 revision: AbstractBackgroundIn 2012, an analysis of the Brazilian mortality database demonstrated under-notification of anaphylaxis deaths due, at least in part, to difficult...

08:37

OtoRhinoLaryngology

Maternal active smoking and its risk of oral clefts

: a Meta-analysisvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: Available online 18 August 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Zhang Xuan, Yang Zhongpeng, Guo Yanjun, Dai Jiaqi, Zhu Yuchi, Shi Bing, Li ChenghaoObjectiveTo...

08:37

OtoRhinoLaryngology

Diagnosis of oral lichen planus

: a position paper of the American Academy of Oral and Maxillofacial Pathologyvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 3Author(s): Yi-Shing Lisa Cheng, Alan...

08:37

OtoRhinoLaryngology

The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis

: a systematic review and meta-analysisvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologySource:Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Jun Ju, Yun Li, Juan Chai, Chao Ma, Qianwei Ni, Zhiyuan Shen, Jianhua Wei, Moyi SunObjectiveWe performed a systematic...

08:37

OtoRhinoLaryngology

Increasing zoledronic acid concentrations,Early changes of the mandible in bisphosphonate-treated patients

Computed tomographic assessment of early changes of the mandible in bisphosphonate-treated patientsvia Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPublication date: September 2016Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 3Author(s): Tohru...

08:37

OtoRhinoLaryngology

Wideband acoustic immittance measurements in assessing crimping status following stapedotomy

A temporal bone study:AbstractObjective: To ascertain if wideband acoustic immitance (WAI) measurements are useful in assessing crimping status following stapedotomy. Design: WAI measurements were obtained using the Mimosa Acoustics HearID system. Wideband chirp sound stimuli and a set of tone stimuli...

08:37

OtoRhinoLaryngology

Skills in audiology

A tool for assessing case history and feedback skills in audiology students working with simulated patients:AbstractObjective: To develop a tool for assessing audiology students taking a case history and giving feedback with simulated patients (SP). Design: Single observation, single group design. Study...

08:37

OtoRhinoLaryngology

The Consumer Quality Index (CQI) ‘Audiology Care’

Clients’ perspective on quality of audiology care: Development of the Consumer Quality Index (CQI) ‘Audiology Care’ for measuring client experiences:AbstractObjective: Clients’ perspective on the quality of audiology care has not been investigated thoroughly. Research has focused primarily on satisfaction...

08:37

OtoRhinoLaryngology

Analysis of the characteristics of persistent postural-perceptual dizziness

A clinical-based study in ChinaAbstractObjective: Persistent postural-perceptual dizziness (PPPD) is a common cause of chronic dizziness, but only a few studies have reported its clinical characteristics, and no related research has been performed in China. Therefore, the purpose of this study was to...

08:37

OtoRhinoLaryngology

Anpassung von Cochleaimplantatsystemen

Anpassung von Cochleaimplantatsystemen: ZusammenfassungBei der Cochleaimplantat(CI)-Anpassung wird der elektrische Dynamikbereich festgelegt, der vom CI-Träger für die Wahrnehmung von Schallereignissen genutzt werden kann. Bei allen CI-Herstellern ist eine große Flexibilität der Einstellung möglich,...