Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 15 Νοεμβρίου 2021

Facile synthesis of novel Bi(0)-SBA-15 adsorbents by an improved impregnation reduction method for highly efficient capture of iodine gas

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J Hazard Mater. 2021 Nov 7;424(Pt C):127678. doi: 10.1016/j.jhazmat.2021.127678. Online ahead of print.

ABSTRACT

Development of high efficient adsorbents to capture iodine is of great significance for the active development of nuclear power. Herein, Bi0-SBA-15 was firstly synthesized and applied for capture of iodine gas. Bi0-SBA-15 materials were prepared by an improved impregnation reduction method. The benefit of this method was that the Bi0 nano particles with flocculent and spherical morphologies were loaded on the surface of SBA-15, which provide abundant active sites for iodine and improve the utilization rate of active sites, so as to attain a record high capture capacity (up to 925 mg/g within 60 min) and high stablitiy (91.2%) at 200 °C. The results demonstrated that the loading of Bi0 on the surface showed a significant impact on the structure of Bi0-SBA-15 and did greatly enhance the iodine capture. Furthermore, the high iodine capture capacity mainly derived from the chemical adsorption in the stable form of BiI3. The obtained Bi0-SBA-15 materials exhibited excellent aqueous and irradiation stability. Thus, the results indicated that the new and highly efficient Bi0-SBA-15 was a potential radioactive iodine gas capture material.

PMID:34775310 | DOI:10.1016/j.jhazmat.2021.127678

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Localization of the neuropeptide manserin in rat dorsal root ganglia: Involvement in nociceptive function

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Via histochem

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Acta Histochem. 2021 Nov 11;123(8):151812. doi: 10.1016/j.acthis.2021.151812. Online ahead of print.

ABSTRACT

Manserin, a neuropeptide discovered in the rat brain, is distributed in the spiral ganglion of the inner ear and carotid body, suggesting it is also localized in another neuron cluster. In this study, we examined manserin's localization in the dorsal root ganglion (DRG) and spinal cord of adult Wistar rats using immunohistochemical analyses. The DRG consists of neuro filament (NF) 200-positive large cells and two types of small cells (calcitonin gene-related peptide (CGRP)-positive peptidergic neurons and isolectin B4 (IB4)-positive non-peptidergic neurons). Manserin was localized in some of the small cells. Fluorescence double immunostaining showed that manserin-positive cells corresponded to some of the CGRP-positive cells. The DRG comprises pseudo-unipolar cells that receive sensory information from the skin and viscera and project to each layer of the dorsal horn of the spinal cord. Manserin was localized in the CGRP-positive layer I and II outer, but not in the IB4-positive layer II inner. These results suggest manserin is localized in CGRP-positive cells in the DRG, projects to the dorsal horn of the spinal cord, and is secreted with other neuropeptides, such as CGRP, to participate in nociceptive function.

PMID:34775224 | DOI:10.1016/j.acthis.2021.151812

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Moxetumomab pasudotox-Third line in Hairy cell leukemia

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Bull Cancer. 2021 Nov 11:S0007-4551(21)00378-7. doi: 10.1016/j.bulcan.2021.07.011. Online ahead of print.

NO ABSTRACT

PMID:34776118 | DOI:10.1016/j.bulcan.2021.07.011

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Medicinal plants used by patients to fight cancer

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Bull Cancer. 2021 Nov 11:S0007-4551(21)00441-0. doi: 10.1016/j.bulcan.2021.09.017. Online ahead of print.

ABSTRACT

Cancer is among the deadliest diseases in the world, especially in developed countries where modern treatments are not available to everyone. In North Africa, and especially in Algeria, few herbal treatments against cancer have been documented despite the richness of flora in these countries. This research aim to documents the medicinal plants used by patient to fight cancer in the northwest of Algeria. Data were collected through ethnobotanical surveys engaging 211 cancer patients in hospitals (departments of medical oncology) in two of the largest provinces in northwest Algeria (Tiaret and Tlemcen). The data were organized into usage reports (UR), while the Informant Consensus Factor (ICF) was calculated to evaluate agreement among informants. The patients investigated were mainly women, of middle age (41-50 years) and i lliterate. In total, 53 medicinal plants used against several types of cancer have been identified. These plants are dominated by Lamiaceae, Apiaceae and Rosaceae. The leaves and powder of plants are most often used in traditional preparations often mixed with honey. The plants most often cited in the survey were Aristolochia longa, Aquilaria malaccensis, Ephedra alata subsp. alenda, while the most often treated cancer were breast, cervical, colorectal and stomach. 23 plants are not known as a treatment against cancers in North Africa, while 25 plants already known as treatment for cancer were cited here to treat specific new types of this disease.

PMID:34776117 | DOI:10.1016/j.bulcan.2021.09.017

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A supportive donor nerve for long-term facial paralysis: Anatomical analysis of the posterior auricular nerve and micro-anatomical comparison with zygomatic nerve

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J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00490-3. doi: 10.1016/j.bjps.2021.09.049. Online ahead of print.

ABSTRACT

BACKGROUND: The posterior auricular nerve (PAN) is an inspiring candidate for the additional axonal source in long-term facial paralysis to improve the functional results of the cross-facial nerve (FN) graft technique. However, no studies have analyzed the PAN's axonal load and its microscopic anatomy to assess its utilization in facial reanimation. The present study aims to examine the anatomical and microscopic features of the PAN to analyze its feasibility as a donor nerve.

METHODS: The bilateral facial side of 14 fresh frozen adult human cadavers was examined for the study. The PAN's anatomical course was recorded, and nerve specimens from the PAN and zygomatic nerve (ZN) were obtained to compare their microscopic anatomy and axon counts using a light microscope and transmission electron microscop e.

RESULTS: The PAN's average branching distance and its course length were 5.8 ± 2.69 mm and 59.2 ± 5.85, respectively. The mean number of myelinated axons was 600.28 ± 69.97 in the PAN and 728.85 ± 166.31 in the ZN. This difference between the two nerves was statistically significant (p = 0.002). However, considering the gender variable, the mean axon counts of PAN and ZN were statistically similar for face sides and their average. Furthermore, the ultrastructural anatomy of both nerves was similar in electron microscopic evaluation.

CONCLUSIONS: The present study confirms that the PAN is a proper candidate to be a supportive donor nerve due to its isolated site, consistent anatomical course, convenient ultrastructural anatomy as well as axonal load.

PMID:34776387 | DOI:10.1016/j.bjps.2021.09.049

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Head and neck research in plastic surgery-Ahead of the rest? An analysis of abstracts presented at British association of plastic reconstructive and aesthetic surgeons meetings

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J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00492-7. doi: 10.1016/j.bjps.2021.09.047. Online ahead of print.

ABSTRACT

INTRODUCTION & AIMS: Historically, the head and neck (H&N) discipline has been integral to the service a plastic surgeon provides. Recently, it has been postulated that its popularity is declining. The output of scientific meetings may indicate the popularity of each sub-speciality interest, also allowing comparison with other H&N conferences.

AIM: To analyse the proportion of H&N themed, podium and poster presentations from British Association of Plastic Reconstructive and Aesthetic Surgeons' (BAPRAS) scientific meetings and the resulting contribution to published literature.

MATERIAL AND METHODS: H&N-themed abstracts were identified from finalised programmes of the biannual BAPRAS meetings between 2008 and 2015. PubMed and Google Scholar databases were searched using keywor ds and author names from each abstract to identify subsequent publication in a peer-reviewed journal.

RESULTS: Overall, 19.3% (350/1815) of BAPRAS abstracts were H&N themed. The publication rate of H&N abstracts was 40.3% (141/350), comprising 43.0% (114/265) of podium and 31.8% (27/85) of poster presentations. H&N reconstruction and cleft and craniofacial were the most frequent topics, with facial palsy having the lowest conversion rate at 15.4%. The mean time to publication was 17.8 months. Research was published in 39 journals, with a mean impact factor of 2.151 (range = 0.772-11.541). The most popular journal was Journal of Plastic, Reconstructive & Aesthetic Surgery (JPRAS; 31.7%; 45/141). Published abstracts originated from 17 different countries. The senior author was a plastic surgeon in 77.3% of abstracts.

CONCLUSIONS: From the multiple potential sub-specialties, H&N-themed abstracts consistently contributed 20% of all research presented at B APRAS. The 40.3% publication rate exceeds the international average of scientific meetings. H&N remains a prominent field in the armamentarium of a plastic surgeon.

PMID:34776391 | DOI:10.1016/j.bjps.2021.09.047

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Orbito-Cranial Gunshot Injuries with Retained Sinonasal Bullets

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J Maxillofac Oral Surg. 2021 Dec;20(4):551-557. doi: 10.1007/s12663-020-01365-4. Epub 2020 Apr 17.

ABSTRACT

INTRODUCTION: Gunshot injuries to the sino-orbital region are rare. In South Africa, where gunshot injuries are common, sino-orbital gunshot injuries are encountered. Sino-orbital gunshot injuries are associated with trauma to surrounding facial and intracranial structures. Therefore, the management of these injuries may be complex and often requires an interdisciplinary approach.

AIMS: To review the management of orbito-cranial gunshot injuries with retained sinonasal bullets.

PATIENTS AND METHODS: Three cases of orbito-cranial gunshot injuries with retained sinonasal bullets were reviewed. Two cases were complicated by cerebrospinal fluid leaks with ensuing meningitis. The retained bullets in all three cases were successfully removed via a transnasal endoscopic approach.

CONCLUSION: Sino-orbital gunshot injuries are rare, but may be encountered in areas with high frequencies of gun violence. An associated anterior skull base fracture with CSF rhinorrhoea poses a risk for meningitis and a low threshold for diagnosis and treatment of meningitis should be maintained. Retained bullets in the paranasal sinuses do not pose an immediate risk and may be removed on an elective basis.

PMID:34776683 | PMC:PMC8555000 | DOI:10.1007/s12663-020-01365-4

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Ewing Sarcoma of the Ethmoid Sinus in an Adult

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Ear Nose Throat J. 2021 Nov 14:1455613211053426. doi: 10.1177/01455613211053426. Online ahead of print.

ABSTRACT

Extraskeletal Ewing sarcoma (EES) is a relatively rare primary tumor of the soft tissues predominantly affecting men in the second and third decades of life. They are a less common form of the cancerous growth known as an Ewing sarcoma, which occurs in bones or soft tissue such as cartilage. Head and neck ESS can require intervention including endoscopic sinus sur gery, septoplasty, inferior turbinectomy, and left internal nasal valve repairs with septal cartilage This is a case report on an unusual presentation of ESS in the sinonasal region.

PMID:34779260 | DOI:10.1177/01455613211053426

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Granulomatose mit Polyangiitis – Manifestationen im Kopf-Hals-Bereich

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Laryngorhinootologie
DOI: 10.1055/a-1580-7037

Die Granulomatose mit Polyangiitis ist eine seltene chronische rheumatologische Systemerkrankung, die mit einer Vaskulitis der kleinen und mittleren Gefäße einhergeht. Am häufigsten betrifft sie die oberen Atemwege, die Lunge und die Nieren. Die Beschwerden sind unspezifisch, häufig beklagen die Patienten anfangs eine Nasenatmungsbehinderung, Borkenbildung in der Nase, Ulzera der Mundschleimhäute oder Epistaxis. Nicht selten wird deshalb der Hals-Nasen-Ohren-Arzt zu Beginn der Krankheit hinzugezogen. Langfristig können schwerwiegende kardiale, renale oder pulmonale Komplikationen auftreten. Die Ätiologie ist bis heute nicht komplett geklärt. Als Therapie wird eine Immunsuppres sion eingeleitet. Klinische und laborchemische Kontrollen sind lebenslang obligat.
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Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Phoniatricians and otorhinolaryngologists approaching oropharyngeal dysphagia: an update on FEES

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Eur Arch Otorhinolaryngol. 2021 Nov 15. doi: 10.1007/s00405-021-07161-1. Online ahead of print.

ABSTRACT

PURPOSE: Oropharyngeal dysphagia (OD) is a common phenomenon in otorhinolaryngology and phoniatrics. As both sub-disciplines have a strong tradition and clinical experience in endoscopic assessment of the upper aerodigestive tract, the implementation of fiberoptic endoscopic evaluation of swallowing (FEES) was an almost self-evident evolution. This review aims to provide an update on FEES and the role of phoniatricians and otorhinolaryngologists using FEES in Europe.

METHODS: A narrative review of the literature was performed by experts in the field of FEES both in the clinical context and in the field of scientific research.

RESULTS: FEES is the first-choice OD assessment technique for both phoniatricians and otorhinolaryngologists. FEES is becoming increasingly popular because of its usefulness, safety, low costs, wide applicability, and feasibility in different clinical settings. FEES can be performed by health professionals of varying disciplines, once adequate knowledge and skills are acquired. FEES aims to determine OD nature and severity and can provide diagnostic information regarding the underlying etiology. The direct effect of therapeutic interventions can be evaluated using FEES, contributing to design the OD management plan. Standardization of FEES protocols and metrics is still lacking. Technological innovation regarding image resolution, frame rate frequency, endoscopic light source specifications, and endoscopic rotation range has contributed to an increased diagnostic accuracy.

CONCLUSION: The rising number of phoniatricians and otorhinolaryngologists performing FEES contributes to the early detection and treatment of OD in an aging European population. Nevertheless, a multidisciplinary approach together with other disciplines is crucial for the success of OD management.

< p>PMID:34779927 | DOI:10.1007/s00405-021-07161-1

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SUVmax for predicting regional control in oropharyngeal cancer

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Eur Arch Otorhinolaryngol. 2021 Nov 15. doi: 10.1007/s00405-021-07169-7. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the predictive value of pretherapeutic metabolic tumor imaging using 18-fluorodeoxyglucose positron emission tomography (FDG-PET) for regional response in oropharyngeal cancer patients undergoing primary (chemo)radiation.

METHODS: Retrospective analysis of oropharyngeal cancer patients treated with primary (chemo)radiation at the University Hospital Zurich from 2010 to 2019 with available FDG-PET. The SUVmax of the largest lymph node metastases was recorded. Regional response was assessed using posttherapeutic FDG-PET at 12 weeks and regional recurrence-free survival.

RESULTS: 95 patients with a mean age of 68.5 years (SD 10.3) were included. The median pretherapeutic nodal SUVmax was 8.3 (interquartile range 4.4-13.3). A pretherapeutic nodal SUVmax above 6 signifi cantly predicted poorer regional recurrence-free survival (log-rank test, P = 0.009) in univariate analysis. However, in multivariate analysis SUVmax above 6 was not significant in predicting regional recurrence-free survival (Cox regression P = 0.189). Clinical N category showed a trend in which a more severe stage had a poorer regional survival (Cox regression P = 0.073).

CONCLUSION: The SUVmax of the largest lymph node metastasis seems to play a role in predicting regional response in oropharyngeal cancer patients, after stratifying for N category. More research is needed to investigate whether highly metabolically active disease is less likely to respond to chemoradiation.

PMID:34779928 | DOI:< a href="https://doi.org/10.1007/s00405-021-07169-7" target="_blank" rel="noopener" class="underlink bluelink">10.1007/s00405-021-07169-7

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