Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
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Δευτέρα 4 Ιουλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,July 5th,2016


Disparate radiocesium leaching from two woody species by acceleration of litter decomposition using microbial inoculation

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 4 δευτερόλεπτα
[image: S0265931X.gif] Publication date: October 2016 *Source:*Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Shin-nosuke Hashida, Toshihiro Yoshihara Studies focusing on the migration of radionuclides in the forest floor have demonstrated that the ecological half-life of radiocesium on organic layer containing the debris of plant litter with various fungi and microorganisms is shorter than that in the deeper soil zone, suggesting that the litter decomposition affects radiocesium mobilization. Here, we showed the involvement of lignin, one of the major cell wall c... περισσότερα »

Cosmic-muon intensity measurement and overburden estimation in a building at surface level and in an underground facility using two BC408 scintillation detectors coincidence counting system

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 4 δευτερόλεπτα
[image: S0265931X.gif] Publication date: October 2016 *Source:*Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Weihua Zhang, Kurt Ungar, Chuanlei Liu, Maverick Mailhot A series of measurements have been recently conducted to determine the cosmic-muon intensities and attenuation factors at various indoor and underground locations for a gamma spectrometer. For this purpose, a digital coincidence spectrometer was developed by using two BC408 plastic scintillation detectors and an XIA LLC Digital Gamma Finder (DGF)/Pixie-4 software and card package. The results indicat... περισσότερα »

Fundamental uncertainty equations for nuclear dating applied to the 140Ba-140La and 227Th-223Ra chronometers

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 4 δευτερόλεπτα
Publication date: October 2016 *Source:*Journal of Environmental Radioactivity, Volumes 162–163 Author(s): S. Pommé, S.M. Collins, A. Harms, S.M. Jerome Basic equations for age dating through activity ratio measurements are presented and applied to nuclear chronometers based on parent-daughter decay. Uncertainty propagation formulae are derived which relate the relative uncertainty on the half-lives and measured activity ratios with the relative uncertainty on the calculated time of a nuclear event. Particular attention is paid to the case of relatively short-lived radionuclides for... περισσότερα »

Measurements of cesium in Arctic beluga and caribou before and after the Fukushima accident of 2011

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 4 δευτερόλεπτα
[image: S0265931X.gif] Publication date: October 2016 *Source:*Journal of Environmental Radioactivity, Volumes 162–163 Author(s): T.J. Stocki, M. Gamberg, L. Loseto, E. Pellerin, L. Bergman, J.-F. Mercier, L. Genovesi, M. Cooke, B. Todd, D. Sandles, J. Whyte, X. Wang Concern from northern communities following the Fukushima Daiichi nuclear accident of March 2011 has prompted a reassessment of the safety of their traditional foods with respect to radioactivity levels. To this end, a study was conducted to measure the levels of radionuclides in Arctic caribou (Rangifer tarandus) and be... περισσότερα »

Longitudinal changes in cerebral blood flow velocities in different clinical courses of migraine

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 5 δευτερόλεπτα
Objective To assess longitudinal changes in cerebral blood flow velocities (CBFVs) according to the clinical course of migraine. Methods We retrospectively included migraine patients with two or more attacks per month at baseline who were followed up within 2 years with transcranial Doppler in a tertiary headache clinic. CBFVs were analyzed in relation to clinical courses, defined as remission (0–1 headache days/month), persistence (2–14/month), or progression (≥15/month) in episodic migraine (EM), and conversion to EM (<15/month) and persistence (≥15/month) in chronic migraine (CM... περισσότερα »

Attacking the Noise Problem: Current Approaches

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 5 δευτερόλεπτα
At Oticon, we believe that being able to understand speech in complex listening environments is critical for people with hearing loss. Despite recent advances in technology, understanding speech in environments where there are other people talking continues to be one of the most difficult challenges with hearing loss. http://ift.tt/29q1sIF

Therapeutic efficacy and safety of Botulinum Toxin A Therapy in Trigeminal Neuralgia: a systematic review and meta-analysis of randomized controlled trials

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 5 δευτερόλεπτα
Several different interventions have been examined to alleviate pain and reduce frequency of trigeminal neuralgia (TN) paroxysms. However, some patients continue to have persistent or recurrent painful attacks… http://ift.tt/29q1ccT

Rejuvenation Research

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 12 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Rejuvenation Research - Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer a... περισσότερα »

Journal of Plastic, Reconstructive & Aesthetic Surgery 162 CITATION

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 12 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Plastic, Reconstructive & Aesthetic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo... περισσότερα »

Lasers in Surgery and Medicine

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 12 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Intern... περισσότερα »

A comparative study of terrestrial gamma dose rate in air measured by thermoluminescent dosimeter, portable survey meter and HPGe gamma spectrometer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: November 2016 Source:Journal of Environmental Radioactivity, Volume 164 Author(s): Yan-Jun Huang, Gui-Yin Guo, Yi He, Li-Tao Yang, Zhen Shan, Chao-Feng Chen, Zhi-Hong Shang-Guan In this paper, three different widely-used measurement techniques for environmental gamma dose rate were studied and compared, i.e., the thermoluminescent dosimeter, the portable survey meter and the spectrometric analysis. Thirteen… Continue reading A comparative study of terrestrial gamma dose rate in air measured by thermoluminescent dosimeter, portable survey meter and HPGe gamma spectr... περισσότερα »

Development of a rapid on-site inspection radioxenon processing system and its applications during IFE14 and related activities

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Chongyang Zhou, Guoqing Zhou, Shujuan Feng, Dingwei Huang, Xinhua Zhao, Elisabeth Wieslander, Kirill Khrustalev, Xiaolong Yu, Ziwei Cheng, Rui Wu, Ronghu Zou To take part in the Integrated Field Exercise in 2014 (IFE14) in Jordan, a rapid on-site inspection radioxenon processing system (XESPM-III) has… Continue reading Development of a rapid on-site inspection radioxenon processing system and its applications during IFE14 and related activities

Ecological effects of exposure to enhanced levels of ionizing radiation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Stanislav A. Geras’kin Irradiation of plants and animals can result in disruption of ecological relationships between the components of ecosystems. Such effects may act as triggers of perturbation and lead to consequences that may differ essentially from expected ones based on effects observed at… Continue reading Ecological effects of exposure to enhanced levels of ionizing radiation

Inverse modeling of the 137Cs source term of the Fukushima Dai-ichi Nuclear Power Plant accident constrained by a deposition map monitored by aircraft

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: November 2016 Source:Journal of Environmental Radioactivity, Volume 164 Author(s): Keiya Yumimoto, Yu Morino, Toshimasa Ohara, Yasuji Oura, Mitsuru Ebihara, Haruo Tsuruta, Teruyuki Nakajima The amount of 137Cs released by the Fukushima Dai-ichi Nuclear Power Plant accident of 11 March 2011 was inversely estimated by integrating an atmospheric dispersion model, an a priori source… Continue reading Inverse modeling of the 137Cs source term of the Fukushima Dai-ichi Nuclear Power Plant accident constrained by a deposition map monitored by aircraft

Identifiability of sorption parameters in stirred flow-through reactor experiments and their identification with a Bayesian approach

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): V. Nicoulaud-Gouin, L. Garcia-Sanchez, M. Giacalone, J.C. Attard, A. Martin-Garin, F.Y. Bois This paper addresses the methodological conditions –particularly experimental design and statistical inference– ensuring the identifiability of sorption parameters from breakthrough curves measured during stirred flow-through reactor experiments also known as continuous flow… Continue reading Identifiability of sorption parameters in stirred flow-through reactor experiments and their iden... περισσότερα »

Long-term measurements of residential radon, thoron, and thoron progeny concentrations around the Chhatrapur placer deposit, a high background radiation area in Odisha, India

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Yasutaka Omori, Ganesh Prasad, Atsuyuki Sorimachi, Sarata Kumar Sahoo, Tetsuo Ishikawa, Devulapalli Vidya Sagar, Rakesh Chand Ramola, Shinji Tokonami The Chhatrapur placer deposit is found in a high background radiation area which has been recently identified on the southeastern coast of India. Previously, some… Continue reading Long-term measurements of residential radon, thoron, and thoron progeny concentrations around the Chhatrapur placer deposit, a high background radiation ... περισσότερα »

Disparate radiocesium leaching from two woody species by acceleration of litter decomposition using microbial inoculation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Shin-nosuke Hashida, Toshihiro Yoshihara Studies focusing on the migration of radionuclides in the forest floor have demonstrated that the ecological half-life of radiocesium on organic layer containing the debris of plant litter with various fungi and microorganisms is shorter than that in the deeper… Continue reading Disparate radiocesium leaching from two woody species by acceleration of litter decomposition using microbial inoculation

Cosmic-muon intensity measurement and overburden estimation in a building at surface level and in an underground facility using two BC408 scintillation detectors coincidence counting system

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Weihua Zhang, Kurt Ungar, Chuanlei Liu, Maverick Mailhot A series of measurements have been recently conducted to determine the cosmic-muon intensities and attenuation factors at various indoor and underground locations for a gamma spectrometer. For this purpose, a digital coincidence spectrometer was developed by… Continue reading Cosmic-muon intensity measurement and overburden estimation in a building at surface level and in an underground facility using two BC408 scintillatio... περισσότερα »

Single-molecule force-spectroscopy reveals the calcium dependency of the alternative conformations in the native state of a {beta}{gamma}-crystallin protein Molecular Biophysics

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 22 δευτερόλεπτα
Though multidomain proteins predominate the proteome of all organisms, and are expected to display complex folding behaviors and significantly greater structural dynamics as compared to single-domain proteins, their conformational heterogeneity and its impact on their interaction with ligands is poorly understood due to lack of experimental techniques. The multidomain calcium-binding β γ-crystallin proteins are particularly… Continue reading Single-molecule force-spectroscopy reveals the calcium dependency of the alternative conformations in the native state of a {beta}{gamma}-cryst... περισσότερα »

Fundamental uncertainty equations for nuclear dating applied to the 140Ba-140La and 227Th-223Ra chronometers

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 24 δευτερόλεπτα
Publication date: October 2016 Source:Journal of Environmental Radioactivity, Volumes 162–163 Author(s): S. Pommé, S.M. Collins, A. Harms, S.M. Jerome Basic equations for age dating through activity ratio measurements are presented and applied to nuclear chronometers based on parent-daughter decay. Uncertainty propagation formulae are derived which relate the relative uncertainty on the half-lives and measured activity… Continue reading Fundamental uncertainty equations for nuclear dating applied to the 140Ba-140La and 227Th-223Ra chronometers

Prevalence of ‘Candidatus Accumulibacter phosphatis’ type II under phosphate limiting conditions

P-limitation in enhanced biological phosphorus removal (EBPR) systems fed with acetate, has generally been considered as a condition leading to enrichment of organisms of the genotype’ Candidatus Competibacter ph… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29fvsnR via IFTTT

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from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29erISK via IFTTT

Intraoperative Magnetic Resonance Imaging Combined with Neurophysiologic Monitoring

Prevalence of Complications in via World Neurosurgery Publication date: September 2016Source:World Neurosurgery, Volume 93Author(s): Johannes Sarnthein, Roger Lüchinger, Marco Piccirelli, Luca Regli, Oliver BozinovBackground and ObjectiveHigh-field intraoperative magnetic resonance imaging (ioMRI) is becoming increasingly available in neurosurgery centers, where it has to be combined with intraoperative neurophysiologic monitoring (IONM). IONM needle electrodes remain on the patient […]

Septal Surgery: Flap Failure or Cerebrospinal Fluid Leakage

Nasoseptal Flap Elevation in Patients with History of Septal Surgery: Does It Increase Flap Failure or Cerebrospinal Fluid Leakage? via World Neurosurgery Publication date: September 2016Source:World Neurosurgery, Volume 93Author(s): Woori Park, Sang Duk Hong, Do-Hyun Nam, Doo-Sik Kong, Gwanghui Ryu, Hyo Yeol Kim, Seung-Kyu Chung, Hun-Jong DhongObjectiveThe nasoseptal flap (NSF) has been shown to be a […]

Cerebral blood flow velocities in different clinical courses of migraine

Longitudinal changes in cerebral blood flow velocities in different clinical courses of migraine: Objective To assess longitudinal changes in cerebral blood flow velocities (CBFVs) according to the clinical course of migraine. Methods We retrospectively included migraine patients with two or more attacks per month at baseline who were followed up within 2 years with transcranial […]

Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Abstract Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients. In some of these patients, residual urine volume and consequently, urinary tracer activity can be higher in the herniated bladder than the native bladder, in which case interpretation can be challenging on conventional planar imaging. We describe an interesting case of physiological activity in a herniated bladder simulating a "tear-drop". This case serves an important reminder that whilst F-18 NaF PET-CT has a similar spectrum of urinary activity to conventional... περισσότερα »

Extranodal diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/29swx07 via IFTTT

Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HC... περισσότερα »

Response

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/29JKqTR via IFTTT

RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/29i4X5R via IFTTT

Extranodal diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
from Cancer via ola Kala on Inoreader http://ift.tt/29swx07 via IFTTT

ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell c... from Cancer via ola Kala on Inoreader http://ift.tt/29krtan via IFTTT

ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Abstract Background Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell carcinoma (RCC) remains unclear. Methods ATF2 knockdown and overexpression studies were performed in RCC cells to evaluate changes in cell viability, cell cycle, apoptosis, migration and invasion. Xenograft models were used to examine the tumorigenic and metastatic capability of RCC cells upon ATF2 suppression. The expression of ATF2 in human RCC samples w... περισσότερα »

Leiodermatolide, a novel marine natural product, has potent cytotoxic and anti-mitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits anti-tumor activity

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
[image: cover.gif?v=1&s=52b7960573a6f44616d24fa7] Abstract Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis occurs before symptoms manifest. Leiodermatolide, a polyketide macrolide with antimitotic activity isolated from a deep water sponge of the genus *Leiodermatium*, exhibits potent and selective cytotoxicity towards the pancreatic cancer cell lines AsPC-1, PANC-1, BxPC-3, and MIA PaCa-2, and potent cytotoxicity against skin, breast and colon cancer cell lines. Induction of apoptosis by leiodermatolid... περισσότερα »

The many unanswered questions related to the German skin cancer screening programme

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Publication date: September 2016 *Source:*European Journal of Cancer, Volume 64 Author(s): Andreas Stang, Claus Garbe, Philippe Autier, Karl-Heinz Jöckel In 2008, the first nationwide skin cancer screening (SCS) programme in the world was established in Germany. The main reason to implement the SCS programme in Germany was the expected reduction of costs of care due to earlier detection of skin cancer. The aim of this commentary is to raise and discuss several unanswered questions related to the German SCS programme. The evidence of a temporary mortality decline of skin melanoma aft... περισσότερα »

Vorinostat in refractory soft tissue sarcomas – Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO)

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 30 δευτερόλεπτα
Publication date: September 2016 *Source:*European Journal of Cancer, Volume 64 Author(s): Thomas Schmitt, Regine Mayer-Steinacker, Frank Mayer, Viktor Grünwald, Jochen Schütte, Jörg T. Hartmann, Bernd Kasper, Johannes Hüsing, Jacek Hajda, Gregor Ottawa, Gunhild Mechtersheimer, Gerd Mikus, Jürgen Burhenne, Lorenz Lehmann, Christoph E. Heilig, Anthony D. Ho, Gerlinde Egerer IntroductionNew treatment options for patients with metastatic Soft Tissue Sarcoma are urgently needed. Preclinical studies suggested activity of vorinostat, a histone deacetylase inhibitor.MethodsA multi-centre, ... περισσότερα »

Therapeutic efficacy and safety of Botulinum Toxin A Therapy in Trigeminal Neuralgia: a systematic review and meta-analysis of randomized controlled trials

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 31 δευτερόλεπτα
Several different interventions have been examined to alleviate pain and reduce frequency of trigeminal neuralgia (TN) paroxysms. However, some patients continue to have persistent or recurrent painful attacks... from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29q1ccT via IFTTT

Rehabilitation 20 citation

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Rehabilitation via xlomafota13 on Inoreader ‎Today, ‎5 ‎Ιουλίου ‎2016, ‏‎8:06:42 πμ Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke ‎Today, ‎5 ‎Ιουλίου ‎2016, ‏‎2 hours ago | Mattlage, A. E., Rippee, M. A., Abraham,... περισσότερα »

Physiology 43 citation

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 36 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Physiology via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and... περισσότερα »

A possible pathogenetic role of IL-23/IL-17 axis in rheumatoid nodules in patients with rheumatoid arthritis

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 36 δευτερόλεπτα
Publication date: Available online 4 July 2016 *Source:*Clinical Immunology Author(s): Natsuko Saito-Sasaki, Yu Sawada, Daisuke Omoto, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29sy8Tu

Asphyxia

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Asphyxia: Impaired breathing that results in severely decreased delivery of oxygen to body tissues. Asphyxia can be fatal. Choking is an example of asphyxia. Traumatic asphyxia is an uncommon cause that results from an intense compression of the chest area. Asphyxia is also known as asphyxiation. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We… Continue reading Asphyxia

Therapeutic efficacy and safety of Botulinum Toxin A Therapy in Trigeminal Neuralgia: a systematic review and meta-analysis of randomized controlled trials

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Several different interventions have been examined to alleviate pain and reduce frequency of trigeminal neuralgia (TN) paroxysms. However, some patients continue to have persistent or recurrent painful attacks… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29q1ccT via IFTTT

Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Abstract Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients. In some of these patients, residual urine volume and consequently, urinary tracer activity can be higher in the herniated bladder than the native bladder, in which case interpretation can be challenging on conventional planar imaging. We describe an interesting… Continue reading Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

Geochemical disturbance of soil cover in the nonferrous mining centers of the Selenga River basin

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Abstract The anthropogenic geochemical transformation of soil cover in large nonferrous mining centers of the Selenga River basin was assessed. The results of the geochemical survey of 2010–2012 revealed the spatial distribution patterns and abundances of 18 hazardous heavy metals and metalloids in the soils of Erdenet (Mongolia) and Zakamensk (Buryat republic, Russian Federation). In… Continue reading Geochemical disturbance of soil cover in the nonferrous mining centers of the Selenga River basin

Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Abstract Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients. In some of these patients, residual urine volume and consequently, urinary tracer activity can be higher in the herniated bladder than the native bladder, in which case interpretation can be challenging on conventional planar imaging. We describe an interesting… Continue reading Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

A possible pathogenetic role of IL-23/IL-17 axis in rheumatoid nodules in patients with rheumatoid arthritis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 38 δευτερόλεπτα
Publication date: Available online 4 July 2016 Source:Clinical Immunology Author(s): Natsuko Saito-Sasaki, Yu Sawada, Daisuke Omoto, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sy8Tu via IFTTT

Attacking the Noise Problem: Current Approaches

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
At Oticon, we believe that being able to understand speech in complex listening environments is critical for people with hearing loss. Despite recent advances in technology, understanding speech in environments where there are other people talking continues to be one of the most difficult challenges with hearing loss. http://ift.tt/29q1sIF

ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 43 δευτερόλεπτα
Abstract Sphingosine-1-phosphate (S1P), which has emerged as a pivotal signaling mediator that participates in the regulation of multiple cellular processes, is derived from various cells, including vascular endothelial cells. S1P accumulates in lipoproteins, especially HDL, and the majority of free plasma S1P is bound to HDL. We hypothesized that HDL-associated S1P is released through mechanisms associated with the HDL maturation process. ApoA-I, a major HDL apolipoprotein, is a critical factor for nascent HDL formation and lipid trafficking via ABCA1. Moreover, apoA-I is capable ... περισσότερα »

Increased risk of hospital admission for dehydration or heat-related illness after initiation of medicines: a sequence symmetry analysis

Alexandros G. SfakianakisστοΘεραπείαΠριν από 44 δευτερόλεπτα
Summary What is known and objective Although several studies have identified factors which increase the risk of heat-related illness, few have assessed the contribution of medicines. To address this knowledge gap, our study aimed to assess the risk of hospital admission for dehydration or other heat-related illness following initiation of medicines. Methods We conducted a retrospective analysis using prescription event symmetry analysis (PESA) of 6700 veterans with incident hospital admission for dehydration or heat-related illness (ICD-10-AM codes E86, X30, T67), between 1 Janu... περισσότερα »

Attacking the Noise Problem: Current Approaches

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 45 δευτερόλεπτα
At Oticon, we believe that being able to understand speech in complex listening environments is critical for people with hearing loss. Despite recent advances in technology, understanding speech in environments where there are other people talking continues to be one of the most difficult challenges with hearing loss. from #Audiology via ola Kala on Inoreader http://ift.tt/29q1sIF via IFTTT

Geochemical disturbance of soil cover in the nonferrous mining centers of the Selenga River basin

Abstract The anthropogenic geochemical transformation of soil cover in large nonferrous mining centers of the Selenga River basin was assessed. The results of the geochemical survey of 2010–2012 revealed the spatial distribution patterns and abundances of 18 hazardous heavy metals and metalloids in the soils of Erdenet (Mongolia) and Zakamensk (Buryat republic, Russian Federation). In […]

Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT

Abstract Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients. In some of these patients, residual urine volume and consequently, urinary tracer activity can be higher in the herniated bladder than the native bladder, in which case interpretation can be challenging on conventional planar imaging. We describe an interesting […]

A possible pathogenetic role of IL-23/IL-17 axis in rheumatoid nodules in patients with rheumatoid arthritis

Publication date: Available online 4 July 2016 Source:Clinical Immunology Author(s): Natsuko Saito-Sasaki, Yu Sawada, Daisuke Omoto, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sy8Tu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Enhanced neuroprotective effect of DHA and EPA-enriched phospholipids against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced oxidative stress in mice brain

Publication date: August 2016 Source:Journal of Functional Foods, Volume 25 Author(s): Dan Wang, Lingyu Zhang, Min Wen, Lei Du, Xiang Gao, Changhu Xue, Jie Xu, Yuming Wang The n-3 polyunsaturated fatty acids (PUFAs) are essential for brain and nervous system growth. The phospholipid forms of docosahexaenoic acid and eicosapentaenoic acid (DHA/EPA-PL) produce remarkable benefits regarding […]

Doctors’ experiences and their perception of the most stressful aspects of complaints processes in the UK: an analysis of qualitative survey data

Objectives To examine doctors’ experiences of complaints, including which aspects are most stressful. We also investigated how doctors felt complaints processes could be improved. Design and methods A qualitative study based on a cross-sectional survey of members of the British Medical Association (BMA). We asked the following: (1) Try to summarise as best as you […]

Diagnosis and mortality in prehospital emergency patients transported to hospital: a population-based and registry-based cohort study

Objective Knowledge about patients after calling for an ambulance is limited to subgroups, such as patients with cardiac arrest, myocardial infarction, trauma and stroke, while population-based studies including all diagnoses are few. We examined the diagnostic pattern and mortality among all patients brought to hospital by ambulance after emergency calls. Design Registry-based cohort study. Setting […]

Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

Introduction Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection […]

Enhanced neuroprotective effect of DHA and EPA-enriched phospholipids against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced oxidative stress in mice brain

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: August 2016 Source:Journal of Functional Foods, Volume 25 Author(s): Dan Wang, Lingyu Zhang, Min Wen, Lei Du, Xiang Gao, Changhu Xue, Jie Xu, Yuming Wang The n-3 polyunsaturated fatty acids (PUFAs) are essential for brain and nervous system growth. The phospholipid forms of docosahexaenoic acid and eicosapentaenoic acid (DHA/EPA-PL) produce remarkable benefits regarding… Continue reading Enhanced neuroprotective effect of DHA and EPA-enriched phospholipids against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced oxidative stress in mice brain

A Comparison of Accuracy of Image- versus Hardware-based Tracking Technologies in 3D Fusion in Aortic Endografting

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 1 ώρα
Publication date: Available online 4 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): A.E. Rolls, B. Maurel, M. Davis, J. Constantinou, G. Hamilton, T.M. Mastracci ObjectivesFusion of three-dimensional (3D) computed tomography and intraoperative two-dimensional imaging in endovascular surgery relies on manual rigid co-registration of bony landmarks and tracking of hardware to provide a 3D overlay (hardware-based tracking, HWT). An alternative technique (image-based tracking, IMT) uses image recognition to register and place the fusion mask. We pres... περισσότερα »

Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 1 ώρα
Publication date: Available online 4 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): J.D. Kakisis, C.N. Antonopoulos, K.G. Moulakakis, F. Schneider, G. Geroulakos, J.B. Ricco ObjectivesThe aim was to evaluate the safety and efficacy of heparin reversal with protamine after completion of carotid endarterectomy (CEA), summarising the available data from both randomised and non-randomised studies.MethodsThe study was a meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated for the outcomes of stroke and wound ... περισσότερα »

Doctors’ experiences and their perception of the most stressful aspects of complaints processes in the UK: an analysis of qualitative survey data

Objectives To examine doctors’ experiences of complaints, including which aspects are most stressful. We also investigated how doctors felt complaints processes could be improved. Design and methods A qualitative study based on a cross-sectional survey of members of the British Medical Association (BMA). We asked the following: (1) Try to summarise as best as you […]

Diagnosis and mortality in prehospital emergency patients transported to hospital: a population-based and registry-based cohort study

Objective Knowledge about patients after calling for an ambulance is limited to subgroups, such as patients with cardiac arrest, myocardial infarction, trauma and stroke, while population-based studies including all diagnoses are few. We examined the diagnostic pattern and mortality among all patients brought to hospital by ambulance after emergency calls. Design Registry-based cohort study. Setting […]

Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

Introduction Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection […]

Correction: Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study

Bhatia A, Bril V, Brull RT, et al. Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study. BMJ Open 2016;6:e012293. The first name of the sixth author was misspelled; the correct spelling is Sabeeh. In […]

Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol

Introduction Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery […]

Research funding for addressing tobacco-related disease: an analysis of UK investment between 2008 and 2012

Introduction Tobacco use is the leading cause of preventable death in the UK. However, research spending on tobacco-related disease, and particularly smoking prevention, is thought to be low. We therefore aimed to assess the relation between tobacco-related research investment and disease burden from 2008 to 2012. Methods We used the Health Research Classification System to […]

Sleeve gastrectomy versus Roux-en-Y gastric bypass for type 2 diabetes and morbid obesity: double-blind randomised clinical trial protocol

Introduction Type 2 diabetes (T2D) in association with obesity is an increasing disease burden. Bariatric surgery is the only effective therapy for achieving remission of T2D among those with morbid obesity. It is unclear which of the two most commonly performed types of bariatric surgery, laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB), […]

Epidemiology of major depressive disorder in South Africa (1997-2015): a systematic review protocol

Introduction Major depressive disorder (MDD) is a leading cause of disease and disability globally and in South Africa. Epidemiological data for MDD are essential to estimate the overall disease burden in a country. The objective of the systematic review is to examine the evidence base for prevalence, incidence, remission, duration, severity, case fatality and excess […]

Prevalence of ‘Candidatus Accumulibacter phosphatis’ type II under phosphate limiting conditions

P-limitation in enhanced biological phosphorus removal (EBPR) systems fed with acetate, has generally been considered as a condition leading to enrichment of organisms of the genotype’ Candidatus Competibacter ph… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29fvsnR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

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from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29erISK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Invertebrate animal species that can withstand temperatures as high as 37°C, the human body temperature, are limited. In the present study, we utilized the two-spotted cricket, *Gryllus bimaculatus*, which lives in tropical and subtropical regions, as an animal model of human pathogenic bacterial infection. Injection of *Pseudomonas aeruginosa* or *Staphylococcus aureus* into the hemolymph killed crickets. Injected *P. aeruginosa* or *S. aureus* proliferated in the hemolymph until the cricket died. The ability of these pathogenic bacteria to kill the crickets was blocked by the ad... περισσότερα »

Combined Infection Training - a pioneering collaborative approach to educating infection specialists

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
This commentary discusses the recent, pioneering, overhaul of training for U.K. doctors wishing to pursue a career in the infection specialities. Changes include the introduction of new curricula that embrace increased collaboration between the laboratory-based and clinical specialties and a broad-based infection training period, named 'Combined Infection Training', which has never been seen before. Here, we discuss the benefits and challenges associated with the collaborative approach to training with particular reference to points that educators responsible for training programm... περισσότερα »

First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males

Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Aims To investigate the safety and tolerability, dose proportionality and relative bioavailability of tablet and oral solution of BI 409306 in healthy male subjects, and to compare the safety and pharmacokinetics in subjects who were extensive metabolisers (EMs) or poor metabolisers (PMs) of cytochrome P450 (CYP)-2C19. Methods This randomised, double-blind, placebo-controlled, single-centre study evaluated single rising doses of BI 409306 (0.5–500 mg) administered as tablet or oral solution to EMs or PMs. Results Of 80 enrolled subjects (mean age, 36.7 years), 79 (CYP2C19 EMs, ... περισσότερα »

Doctors’ experiences and their perception of the most stressful aspects of complaints processes in the UK: an analysis of qualitative survey data

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objectives To examine doctors’ experiences of complaints, including which aspects are most stressful. We also investigated how doctors felt complaints processes could be improved. Design and methods A qualitative study based on a cross-sectional survey of members of the British Medical Association (BMA). We asked the following: (1) Try to summarise as best as you… Continue reading Doctors’ experiences and their perception of the most stressful aspects of complaints processes in the UK: an analysis of qualitative survey data

Diagnosis and mortality in prehospital emergency patients transported to hospital: a population-based and registry-based cohort study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective Knowledge about patients after calling for an ambulance is limited to subgroups, such as patients with cardiac arrest, myocardial infarction, trauma and stroke, while population-based studies including all diagnoses are few. We examined the diagnostic pattern and mortality among all patients brought to hospital by ambulance after emergency calls. Design Registry-based cohort study. Setting… Continue reading Diagnosis and mortality in prehospital emergency patients transported to hospital: a population-based and registry-based cohort study

Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection… Continue reading Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

Correction: Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Bhatia A, Bril V, Brull RT, et al. Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study. BMJ Open 2016;6:e012293. The first name of the sixth author was misspelled; the correct spelling is Sabeeh. In… Continue reading Correction: Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PRE... περισσότερα »

Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery… Continue reading Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol

Research funding for addressing tobacco-related disease: an analysis of UK investment between 2008 and 2012

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Tobacco use is the leading cause of preventable death in the UK. However, research spending on tobacco-related disease, and particularly smoking prevention, is thought to be low. We therefore aimed to assess the relation between tobacco-related research investment and disease burden from 2008 to 2012. Methods We used the Health Research Classification System to… Continue reading Research funding for addressing tobacco-related disease: an analysis of UK investment between 2008 and 2012

Sleeve gastrectomy versus Roux-en-Y gastric bypass for type 2 diabetes and morbid obesity: double-blind randomised clinical trial protocol

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Type 2 diabetes (T2D) in association with obesity is an increasing disease burden. Bariatric surgery is the only effective therapy for achieving remission of T2D among those with morbid obesity. It is unclear which of the two most commonly performed types of bariatric surgery, laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB),… Continue reading Sleeve gastrectomy versus Roux-en-Y gastric bypass for type 2 diabetes and morbid obesity: double-blind randomised clinical trial protocol

Epidemiology of major depressive disorder in South Africa (1997-2015): a systematic review protocol

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Major depressive disorder (MDD) is a leading cause of disease and disability globally and in South Africa. Epidemiological data for MDD are essential to estimate the overall disease burden in a country. The objective of the systematic review is to examine the evidence base for prevalence, incidence, remission, duration, severity, case fatality and excess… Continue reading Epidemiology of major depressive disorder in South Africa (1997-2015): a systematic review protocol

Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate… Continue reading Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models

Correction: Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study

Bhatia A, Bril V, Brull RT, et al. Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study. BMJ Open 2016;6:e012293. The first name of the sixth author was misspelled; the correct spelling is Sabeeh. In […]

Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol

Introduction Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery […]

Research funding for addressing tobacco-related disease: an analysis of UK investment between 2008 and 2012

Introduction Tobacco use is the leading cause of preventable death in the UK. However, research spending on tobacco-related disease, and particularly smoking prevention, is thought to be low. We therefore aimed to assess the relation between tobacco-related research investment and disease burden from 2008 to 2012. Methods We used the Health Research Classification System to […]

Sleeve gastrectomy versus Roux-en-Y gastric bypass for type 2 diabetes and morbid obesity: double-blind randomised clinical trial protocol

Introduction Type 2 diabetes (T2D) in association with obesity is an increasing disease burden. Bariatric surgery is the only effective therapy for achieving remission of T2D among those with morbid obesity. It is unclear which of the two most commonly performed types of bariatric surgery, laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB), […]

Epidemiology of major depressive disorder in South Africa (1997-2015): a systematic review protocol

Introduction Major depressive disorder (MDD) is a leading cause of disease and disability globally and in South Africa. Epidemiological data for MDD are essential to estimate the overall disease burden in a country. The objective of the systematic review is to examine the evidence base for prevalence, incidence, remission, duration, severity, case fatality and excess […]

Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models

Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate […]

Adenocarcinoma risk in patients registered with polish barrett’s oesophagus registry

Summary Barrett’s Oesophagus (BO) is a complication of chronic gastro-oesophageal reflux disease (GORD) and is a major risk factor for oesophageal adenocarcinoma. Current guidelines are based on data showing a 0.5% annual malignancy progression rate. The Polish Barrett’s Oesophagus Registry (POBOR) was established to characterize Polish patients with BO and estimate the risk of malignant […]

Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: cohort study using electronic health records

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29ehSjA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma

Abstract Background Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell carcinoma (RCC) remains unclear. Methods ATF2 knockdown and overexpression studies were performed in RCC cells to evaluate changes in cell viability, cell […]

New low-cost automated system of closed chambers to measure greenhouse gas emissions from the tundra

Publication date: 15 November 2016 Source:Agricultural and Forest Meteorology, Volumes 228–229 Author(s): Samuel Gagnon, Emmanuel L’Hérault, Mickaël Lemay, Michel Allard The northern high latitudes represent the world’s largest soil carbon reservoir. Due to the rapid warming in the Arctic, permafrost thawing is expected to lead to increased emissions of greenhouse gases (GHG). Therefore, quantifying these […]

Adenocarcinoma risk in patients registered with polish barrett’s oesophagus registry

Summary Barrett’s Oesophagus (BO) is a complication of chronic gastro-oesophageal reflux disease (GORD) and is a major risk factor for oesophageal adenocarcinoma. Current guidelines are based on data showing a 0.5% annual malignancy progression rate. The Polish Barrett’s Oesophagus Registry (POBOR) was established to characterize Polish patients with BO and estimate the risk of malignant […]

Adenocarcinoma risk in patients registered with polish barrett's oesophagus registry

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Summary Barrett's Oesophagus (BO) is a complication of chronic gastro-oesophageal reflux disease (GORD) and is a major risk factor for oesophageal adenocarcinoma. Current guidelines are based on data showing a 0.5% annual malignancy progression rate. The Polish Barrett's Oesophagus Registry (POBOR) was established to characterize Polish patients with BO and estimate the risk of malignant progression. POBOR was established in 1999 after a dedicated training of endoscopists and histopathologists. Physicians registered patients using a dedicated registry form. After excluding patient... περισσότερα »

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. Post-exposure TTS was […]

Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event

Cetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but se… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29hOU88 via IFTTT

Use and misuse of common terminology criteria for adverse events in cancer clinical trials

Common Terminology Criteria for Adverse Events, Version 3.0 (CTCAE v3.0) were released in 2003 and have been used widely to report toxicity in publications or presentations describing cancer clinical trials. H… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29kkRsD via IFTTT

Lifestyle in Multiple Myeloma – a longitudinal cohort study protocol

Deterioration in bone health is one of the presenting symptoms of Multiple Myeloma (MM), a cancer of plasma cells. As a consequence of this condition, patients suffer bone pain and bone damage and report cance… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29kkDBx via IFTTT

The use of a multiple imputation method to investigate the trends in Histologic types of lung cancer in Songkhla provin ce, Thailand, 1989–2013

The incidence of lung cancer in many parts of the country as shown in cancer registry statistics is not decreasing. The incidence of adenocarcinoma (ADCA) in Songkhla is now higher than that of squamous cell c… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29hPfYx via IFTTT

Leiodermatolide, a novel marine natural product, has potent cytotoxic and anti-mitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits anti-tumor activity

Abstract Pancreatic cancer, the fourth leading cause of cancer death in the United States, has a negative prognosis because metastasis occurs before symptoms manifest. Leiodermatolide, a polyketide macrolide with antimitotic activity isolated from a deep water sponge of the genus Leiodermatium, exhibits potent and selective cytotoxicity towards the pancreatic cancer cell lines AsPC-1, PANC-1, BxPC-3, […]

Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke

*Background*. Insulin-like growth factor-1 (IGF-1) is neuroprotective after stroke and is regulated by insulin-like binding protein-3 (IGFBP-3). In healthy individuals, exercise and improved aerobic fitness (peak oxygen uptake; peak VO2) increases IGF-1 in circulation. Understanding the relationship between estimated prestroke aerobic fitness and IGF-1 and IGFBP-3 after stroke may provide insight into the benefits of exercise and aerobic fitness on stroke recovery. *Objective*. The purpose of this study was to determine the relationship of IGF-1 and IGFBP-3 to estimated prestroke ... περισσότερα »

Neurofeedback ineffective in paediatric brain tumour survivors: Results of a double-blind randomised placebo-controlled trial

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Publication date: September 2016 *Source:*European Journal of Cancer, Volume 64 Author(s): Marieke Anna de Ruiter, Jaap Oosterlaan, Antoinette Yvonne Narda Schouten-van Meeteren, Heleen Maurice-Stam, Dannis Gilbert van Vuurden, Corrie Gidding, Laura Rachel Beek, Bernd Granzen, Huib N. Caron, Martha Alexandra Grootenhuis BackgroundMany paediatric brain tumour survivors (PBTS) suffer from neurocognitive impairments. Promising effects of neurofeedback (NF) on neurocognitive functioning have been reported, however research into NF for PBTS has not been conducted. We investigated the eff... περισσότερα »

British Cosmetic Dermatology Group

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29erP0E via IFTTT