Prevalence of bifid mandibular canals by cone beam computed tomography
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 17 δευτερόλεπτα
Abstract Purpose The aim of this study was to evaluate the prevalence of bifid mandibular canals (BMC) by cone beam computed tomography (CBCT). Materials and methods We examined CT scans from 300 patients both male and female, aged 25 to 87 years. The subjects were divided into groups according to gender, male group (MG) and female group (FG) as well as subgroups according to the side, right ® and left (L). Tomographic acquisitions were performed on the device I-Cat ® Classic. Image analysis was performed on the XoranCat ® software of the equipment itself, aided by image filters a... περισσότερα »
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 17 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste http://ift.tt/29Vrzcp
Prognostic significance of VEGF-C in predicting micrometastasis and isolated tumour cells in N0 oral squamous cell carcinoma
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 17 δευτερόλεπτα
[image: cover.gif?v=1&s=fa071a998e1fff64ddf228a0] Background Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a well-known independent prognostic factor. However, the identification of occult tumour cells within the lymph nodes has remained a challenge for the pathologist as well as the clinician. Objective The aim of this study was to determine the prevalence of micrometastasis and isolated tumour cells (ITCs) in pathologically staged N0 OSCC of the tongue and buccal mucosa and to assess its correlation with vascular endothelial growth factor C, (VEGF-C) expression... περισσότερα »
Differential Laser-induced Perturbation Spectroscopy for Analysis of Mixtures of the Fluorophores L-Phenylalanine, L-Tyrosine, and L-Tryptophan Using a Fluorescence Probe
Abstract Quantitative detection of common endogenous fluorophores is accomplished using differential laser-induced perturbation spectroscopy (DLIPS) with a 193-nm UV fluorescence probe and various UV perturbation wavelengths. In this study, DLIPS is explored as an alternative to traditional fluorescence spectroscopy alone, with a goal of exploring natural fluorophores pursuant to biological samples and tissue analysis. To this end, aromatic amino acids, namely, L-Phenylalanine, L-Tyrosine and L-Tryptophan are mixed with differing mass ratios and then classified with various DLIPS s... περισσότερα »
Photoprotective Potential of Baccharis antioquensis (Asteraceae) as Natural Sunscreen
Abstract In the quest for new natural agents of photoprotection, we evaluated the photoprotective and antioxidant activity of *B. antioquensis* leaf extracts as well as its phenolic composition. The methanolic extract treated with activated carbon showed the highest absorption coefficients for UVA-UVB radiation, as well as an antioxidant capacity comparable to BHT. Furthermore, the formulation containing this extract showed suitable sensorial and photostable characteristics for topical use, and significant values of UVAPF, critical wavelength (*λ*c), UVA/UVB ratio and SPF (5.3, 37... περισσότερα »
Further evidence for genotype-phenotype disparity in Griscelli syndrome
Abstract First described in 1978, Griscelli syndrome (GS) is a rare autosomal recessive disorder featuring pigmentary dilution of hair and skin.1 GS is caused by mutations in any of three genes encoding a tripartite protein complex essential for melanosome transport.2 GS1 (MIM214450) presents as hypomelanosis with primary neurological defects and is caused by mutations in *MYO5A*,3 and which also may be the same entity as Elejalde syndrome (MIM256710).4 This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://if... περισσότερα »
A prospective randomised controlled trial comparing infliximab and etanercept in patients with moderate to severe chronic plaque type psoriasis Psoriasis Infliximab versus Etanercept Comparison Evaluation, the PIECE study
Abstract Background There is currently no independent data available comparing infliximab and etanercept in psoriasis. Our objective was to compare these biologicals, without funding from pharmaceutical companies. Methods 50 Patients were randomised equally to etanercept (n=23) 50mg subcutaneous twice-weekly or infliximab (n=25) 5mg/kg at week 0, 2, 6, 14 and 22 intravenously. After 24 weeks, 19 patients stopped and 22 continued treatment and were followed up to week 48. Primary outcome was ≥75% improvement of psoriasis area and severity index (PASI75) at week 24. Secondary outc... περισσότερα »
A Systematic Review of Patient-Reported Outcomes (PROs) in Patients with Cutaneous Lupus Erythematosus (CLE)
Abstract Background Cutaneous lupus erythematosus (CLE) is a chronic, dermatologic autoimmune disease marked by photosensitive lesions that can lead to hyperpigmentation changes, scarring, and hair loss. Health-related quality of life (HRQoL) in CLE patients is severely impaired. Given the heterogeneous nature of CLE, the health perceptions of patients can differ significantly from the clinicians'. It is, therefore, important to use subjective measures, such as patient-reported outcomes (PROs) to be able to capture HRQoL in CLE patients. Objectives We sought to conduct a systema... περισσότερα »
Hydrocephalus in tuberculous meningitis – how late can it present?
10.1080/23744235.2016.1207250<br>Noella Maria Delia Pereira from Infection via ola Kala on Inoreader http://ift.tt/29HRmoQ via IFTTT
Low-dose growth hormone therapy reduces inflammation in HIV-infected patients: a randomized placebo-controlled study
10.1080/23744235.2016.1201722<br>Johanne Bjerre Lindboe from Infection via ola Kala on Inoreader http://ift.tt/29IctDo via IFTTT
International guidelines: the need to standardize the management of candidaemia
10.1080/23744235.2016.1207251<br>Laura Jack from Infection via ola Kala on Inoreader http://ift.tt/29HQRv7 via IFTTT
Aetiology and outcome of pneumoniae in HIV-positive patients in the antiretroviral era
10.1080/23744235.2016.1206669<br>Maria C Leoni from Infection via ola Kala on Inoreader http://ift.tt/29IcdUZ via IFTTT
The Role of NOD1 and NOD2 in Host Defense against Chlamydial Infection
Chlamydial species are common intracellular parasites that cause various diseases, mainly characterized by persistent infection, which lead to inflammatory responses modulated by pattern recognition receptors (PRRs). The best understood PRRs are the extracellular Toll-like receptors, but recent significant advances have focused on two important proteins, NOD1 and NOD2, which are members of the intracellular nucleotide-binding oligomerization domain receptor family and are capable of triggering the host innate immune signaling pathways. This results in the production of pro-inflamm... περισσότερα »
A conserved OmpA-like protein in Legionella pneumophila required for efficient intracellular replication
The OmpA-like protein domain has been associated with peptidoglycan binding proteins, and is often found in virulence factors of bacterial pathogens. The intracellular pathogen *Legionella pneumophila* encodes for six proteins that contain the OmpA-like domain, among them the highly conserved uncharacterized protein we named CmpA. Here we set out to characterize the CmpA protein and determine its contribution to intracellular survival of *L. pneumophila*. Secondary structure analysis suggests that CmpA is an inner membrane protein with a peptidoglycan binding domain at the C-teminu... περισσότερα »
The Role of NOD1 and NOD2 in Host Defense against Chlamydial Infection
Chlamydial species are common intracellular parasites that cause various diseases, mainly characterized by persistent infection, which lead to inflammatory responses modulated by pattern recognition receptors (PRRs). The best understood PRRs are the extracellular Toll-like receptors, but recent significant advances have focused on two important proteins, NOD1 and NOD2, which are members of the intracellular nucleotide-binding oligomerization domain receptor family and are capable of triggering the host innate immune signaling pathways. This results in the production of pro-inflamm... περισσότερα »
A conserved OmpA-like protein in Legionella pneumophila required for efficient intracellular replication
The OmpA-like protein domain has been associated with peptidoglycan binding proteins, and is often found in virulence factors of bacterial pathogens. The intracellular pathogen *Legionella pneumophila* encodes for six proteins that contain the OmpA-like domain, among them the highly conserved uncharacterized protein we named CmpA. Here we set out to characterize the CmpA protein and determine its contribution to intracellular survival of *L. pneumophila*. Secondary structure analysis suggests that CmpA is an inner membrane protein with a peptidoglycan binding domain at the C-teminu... περισσότερα »
Nystatin and miconazole: Pharmacological and clinical evidence regarding interactions with warfarin
Nystatin and miconazole: Pharmacological and clinical evidence regarding interactions with warfarin: Abstract Objective A retrospective case series published in 2012 concluded that miconazole and nystatin used as topical antifungal drugs appear to interact equally strongly with warfarin. If confirmed, this finding has significant implications for clinical practice. This study evaluates the evidence. Materials and methods Evidence from the pharmacology literature, the medical literature, and the ‘yellow card’ adverse drug reaction surveillance reports were analysed regarding possible... περισσότερα »
A Case of Scurvy--Uncommon Disease--Presenting as Panniculitis, Purpura, and Oligoarthritis
A Case of Scurvy--Uncommon Disease--Presenting as Panniculitis, Purpura, and Oligoarthritis: Importance: Scurvy remains prevalent in certain populations, including addicts, people of low socioeconomic status, and the severely malnourished. It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints. This case presentation and literature review highlights the common pathophysiological findings associated with scurvy and current methods of diagnosis and treatment. Observ... περισσότερα »
Novel Thioester Prodrug of N-acetylcysteine for Odor Masking and Bioavailability Enhancement
Novel Thioester Prodrug of N-acetylcysteine for Odor Masking and Bioavailability Enhancement: Background: The mucolytic N-acetylcysteine (NAC) is used to control the excessive mucus secretion if mucus is the underlying cause of broncho-constriction. Its major drawbacks are poor bioavailability due to extensive first pass effect, poor lipophilicity, high protein binding and offensive odor. <p> Methods: For minimizing above shortcomings of NAC, in present study thioester (A1) prodrug of NAC was synthesized by conventional as well as microwave-assisted methods. Release studies of A...</p>
Evaluation of Low-Dose Ultraviolet Light C for Reduction of Select ESKAPE Pathogens in a Canine Skin and Muscle Model
Evaluation of Low-Dose Ultraviolet Light C for Reduction of Select ESKAPE Pathogens in a Canine Skin and Muscle Model: Photomedicine and Laser Surgery , Vol. 0, No. 0. Author information Mauricio Dujowich, DVM, DACVS, J. Brad Case, DVM, MS, DACVS, Gary Ellison, DVM, MS, DACVS, andJames F.X. Wellehan, DVM, MS, PhD, DACZM, DACVM Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida. Address correspondence to: *Mauricio Dujowich* *Department of Small Animal Clinical Sciences* *University of Florida College of Veterina... περισσότερα »
The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study
The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study: Photomedicine and Laser Surgery , Vol. 0, No. 0. Author information Diana Terlević Dabić, DMD,1 Sanja Jurišić, DMD,2 Vanja Vučićević Boras, DMD, PhD,3 Dragana Gabrić,DMD, PhD,4 Ivona Bago, DMD, PhD,5 and Danko Velimir Vrdoljak, DDS, PhD6 1Private Dental Practice, Ljubljana, Slovenia. 2Private Dental Practice, Mostar, Croatia. 3Department of Oral Medicine, School of Dental Medicine and Clinical Hospital Centre Zagreb, Zagreb, Croatia. 4Department of Oral Surgery, School of Den... περισσότερα »
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns: Single amino acid resolution mapping of linear peanut allergen epitopes using high density peptide arrays demonstrates patient specific and highly persistent antibody binding patterns. Abstract Here, high-density peptide arrays were applied to map linear IgE and IgG4 epitopes at the single amino acid level in patients. IgE and IgG4 binding patterns were heterogeneous between patients but very similar for each patient over time. A detailed inspection of the epitopes r... περισσότερα »
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin: IL-22 induction by mechanical injury limits cutaneous infection of Staphylococcus aureus. AbstractBackground *S. aureus* is an opportunistic pathogen that colonizes the skin of patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the cytokines IL-17A and IL-17F, which drive the expression of the neutrophil-attracting chemokines are important for the clearance of *S. aureus* infection. The cytokine IL-22 is often co-produced by IL-17 secreting cells... περισσότερα »
Humoral and cellular responses to casein in food protein-induced enterocolitis to cow’s milk
Humoral and cellular responses to casein in food protein-induced enterocolitis to cow’s milk: We confirm the paucity of humoral responses in cow milk FPIES. Our data indirectly suggest a major role of neutrophils and mast cells in FPIES. In addition, IL-10 may play a role in tolerance acquisition.
Treatment Effect of Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis: Pooled Analyses
Treatment Effect of Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis: Pooled Analyses: By indirect comparison, SLIT-tablet effects on nasal symptoms were nearly as large as an intranasal corticosteroid, and numerically greater than montelukast or an antihistamine for SAR. HDM SLIT-tablets were numerically greater versus all pharmacotherapies for PAR.
Food allergy is associated with high dietary advanced glycation end products and pro-glycating dietary sugars that mimic alarmins
“The False Alarm” hypothesis: The incidence of food allergy has risen dramatically in the last few decades in Westernized developed countries. We propose that the Western life style and diet promote innate danger signals and immune responses through the production of “alarmins”. Alarmins are endogenous molecules secreted from cells undergoing non-programmed cell death that signal tissue and cell damage. High Molecular Group Box 1 (HMGB1) is a major alarmin that binds to the Receptor for Advanced Glycation End products (RAGE).
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects: This article examines the mechanism of action underlying the allergy-protective effects of the cowshed bacterium, Lactococcus lactis G121. The mechanism involves bacterial uptake by DCs, followed by endosomal acidification and sensing of bacterial RNA by endosomal pattern recognition receptors.
Mutations in LAT lead to a novel form of severe combined immunodeficiency
Mutations in LAT lead to a novel form of severe combined immunodeficiency: Severe combined immunodeficiency can arise from a number of different genetic causes. Here, we show that mutations in LAT can lead to SCID and highlight the critical role of LAT in TCR signalling in T cell development.
IgE-reactivity profiles to non-specific Lipid Transfer Proteins (ns-LTP) in a north-western European country
IgE-reactivity profiles to non-specific Lipid Transfer Proteins (ns-LTP) in a north-western European country: Specific IgE reactivity to ns-LTPs is prevalent in patients with pollen and/or plant food allergic symptoms from a north-western European region, although in the majority of cases these sIgE antibodies appear not clinically relevant.
Diversity of T-helper cytokine-profiles in chronic rhinosinusitis: A multicenter study in Europe, Asia and Oceania
Diversity of T-helper cytokine-profiles in chronic rhinosinusitis: A multicenter study in Europe, Asia and Oceania: This study for the first time evaluates inflammatory patterns based on T-helper cell cytokines and granulocyte inflammation markers in patients with chronic rhinosinusitis from different continents, identifying various compositions of endotypes within the clinical phenotypes. AbstractBackground To date no study has evaluated the diversity of T-helper cell cytokine patterns of chronic rhinosinusitis (CRS) patients among centers in different continents employing ide... περισσότερα »
The American Sleep and Breathing Academy’s protocol
Doctors support ASBA for Leading with HST Procedures, Protocols and Practice Management: It is no secret that dental sleep medicine and sleep apnea awareness continues to grow, with a host of news media and major online websites granting sleep disorders a significant amount of media coverage. From editorials, ed-op’s, physician and dentist blogs to major celebrities such as Dr. Oz and Ariana Huffington discussing Sleep issues with their audiences. Even public awareness events have taken an enormous leap from 5-20 persons in a hotel meeting room to the largest sleep apnea awareness ... περισσότερα »
Tracheostomy decannulatio
n at the Royal Hospital for Sick Children in Glasgow: predictors of success and failure: Tracheostomy techniques, indications and care are extensively covered in the literature. However, little is written about the process of removing the tracheostomy tube. At the Royal Hospital for Sick Children in Glasgow we use a stepwise ward-based protocol for safe tracheostomy decannulation. Our aim therefore was to review all the paediatric tracheostomy decannulations that we attempted over the last 3 years to evaluate our protocol, to determine our success rate and to see whether any modific... περισσότερα »
Assessing the Reliability and Use of the Expository Scoring Scheme as a Measure of Developmental Change in Monolingual English and Bilingual French/English Children
Assessing the Reliability and Use of the Expository Scoring Scheme as a Measure of Developmental Change in Monolingual English and Bilingual French/English Children: Purpose The Expository Scoring Scheme (ESS) is designed to analyze the macrostructure of descriptions of a favorite game or sport. This pilot study examined inter- and intrarater reliability of the ESS and use of the scale to capture developmental change in elementary school children. Method Twenty-four children in 2 language groups (monolingual English and bilingual French/English) and 2 age groups (7–8 years, 11–12 ... περισσότερα »
Mandibular reconstruction with the vascularized fibula flap: comparison of virtual planning surgery and conventional surgery
Mandibular reconstruction with the vascularized fibula flap: comparison of virtual planning surgery and conventional surgery: This study evaluated the accuracy of mandibular reconstruction and assessed clinical outcomes in both virtual planning and conventional surgery patients. ProPlan CMF surgical planning software was used preoperatively in the virtual planning group. In the virtual planning group, fibula flaps were harvested and osteotomized, and the mandibles were resected and reconstructed assisted by the prefabricated cutting guides and templates. The main outcome measures in... περισσότερα »
p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma
p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma: Patients with HNSCC are at considerable risk of mortality, with more than 300,000 deaths worldwide attributable to the disease per year [1]. The major causes of HNSCC-related deaths are cervical node and distant metastasis [2]. Delineation of the mechanisms involved in the metastastic behavior of HNSCC is of the utmost importance for effective management of this disease.
Decreased Symptoms without Augmented Skin Blood Flow in Subjects with RLS/WED after Vibration Treatment
Decreased Symptoms without Augmented Skin Blood Flow in Subjects with RLS/WED after Vibration Treatment: Study Objectives:Vascular disturbances leading to tissue hypoxia have been named as a possible cause for RLS/WED. Vibration to the whole body (WBV) in subjects with RLS/WED results in increased skin blood flow (SBF). The aims of this investigation were to (1) determine if a two-week treatment with WBV will decrease symptoms associated with RLS/WED and, (2) if so, determine if the mechanism for improvement in symptoms is related to an increase in SBF, as measured in flux. Met... περισσότερα »
Efficiency calibration for in situ γ-ray measurements on the seabed using Monte Carlo simulations: Application in two different marine environments
[image: S0265931X.gif] Publication date: November 2016 *Source:*Journal of Environmental Radioactivity, Volume 164 Author(s): E.G. Androulakaki, C. Tsabaris, G. Eleftheriou, M. Kokkoris, D.L. Patiris, F.K. Pappa, R. Vlastou A new approach for calibrating an in situ detection system for measurements in marine sediments has been developed. The efficiency calibration was deduced on full spectral range by Monte Carlo simulations (MCNP5 code) considering a close detector-seabed geometry set-up. Moreover, the influence of the detection efficiency with respect to the variations of the sedi... περισσότερα »
Half-life of IgE in the serum and the skin: Consequences for anti-IgE therapy in allergic disease
Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Monica G. Lawrence, Judith A. Woodfolk, Alexander J. Schuyler, Leland C. Stillman, Martin D. Chapman, Thomas A.E. Platts-Mills We present results from clinical studies on plasma infusion done in the late 1970s in patients with hypogammaglobulinemia, in which we documented the short half-life of both total and allergen specific IgE in the serum. The development of specific allergic sensitization in the skin of those patients followed by the gradual decline in sensitization ov... περισσότερα »
Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: report of two siblings
Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Johannes Trück, Dominic F. Kelly, John M. Taylor, Anne Kathrin Kienzler, Tracy Lester, Anneke Seller, Andrew J. Pollard, Smita Y. Patel We describe the phenotype of 2 siblings with combined immunodeficiency due to CTPS1 deficiency and demonstrate the value of WES for rapid diagnosis of primary immunodeficiency even for conditions whose phenotype is not well recognized. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29HB27A
Vitamin D and antimicrobial peptide levels in patients with Atopic Dermatitis (AD) and Atopic Dermatitis complicated by Eczema Herpeticum (ADEH): A Pilot Study
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Lujain H. Albenali, Simon Danby, Manar Moustafa, Kirsty Brown, John Chittock, Fiona Shackley, Michael J. Cork Teaser In this study, Vitamin D supplementation results in improved clinical severity of atopic dermatitis and increased skin surface LL-37 levels, analyzed by a novel, non-invasive method. Vitamin D supplementation could be a therapeutic option in AD. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29HXV6L
Pre-existing Anti-PEG Antibodies Are Associated with Severe Immediate Allergic Reactions to Pegnivacogin, a PEGylated Aptamer
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Thomas J. Povsic, Monica G. Lawrence, A. Michael Lincoff, Roxana Mehran, Christopher P. Rusconi, Steven L. Zelenkofske, Zhen Huang, Jeff Sailstad, Paul W. Armstrong, P. Gabriel Steg, Christoph Bode, Richard C. Becker, John H. Alexander, N. Franklin Adkinson, Arnold I. Levinson Teaser First-dose severe allergic reactions to pegnivacogin, a PEGylated RNA aptamer, occured only in patients with pre-formed IgG anti-PEG antibodies. Biochemical studeis impli... περισσότερα »
Successful unrelated cord blood transplant for complete IFN-γR2 deficiency
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Camilia Kamoun, Megan Morsheimer, Kathleen E. Sullivan, Steven M. Holland, Charlotte Cunningham Rundles, Nancy Bunin, Jennifer R. Heimall Teaser We report a case of complete IFN-γR2 deficiency successfully treated with an unrelated cord blood transplant, which has yet to be described for any interferon γ receptor deficiency. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29HXZDJ
Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase δ syndrome–like immunodeficiency
Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Yuki Tsujita, Kanako Mitsui-Sekinaka, Kohsuke Imai, Tzu-Wen Yeh, Noriko Mitsuiki, Takaki Asano, Hidenori Ohnishi, Zenichiro Kato, Yujin Sekinaka, Kiyotaka Zaha, Tamaki Kato, Tsubasa Okano, Takehiro Takashima, Kaoru Kobayashi, Mitsuaki Kimura, Tomoaki Kunitsu, Yoshihiro Maruo, Hirokazu Kanegane, Masatoshi Takagi, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Osamu Ohara, Satoshi Oka... περισσότερα »
Clinical Trial Data Access – Opening Doors With TrialShare
[image: alertIcon.gif] Publication date: Available online 12 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Adam L. Asare, Vincent J. Carey, Daniel Rotrosen, Gerald T. Nepom from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29HBbb4
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via ola Kala on Inoreader http://ift.tt/29Vrzcp via IFTTT
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via xlomafota13 on Inoreader http://ift.tt/29Vrzcp via IFTTT
Effects of chronic exposure to acidic environment on the response of tumor cells to radiation
10.1080/09553002.2016.1206222<br>So-Ra Kim from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/2afcwGI via IFTTT
Prognostic significance of VEGF-C in predicting micrometastasis and isolated tumour cells in N0 oral squamous cell carcinoma
[image: cover.gif?v=1&s=fa071a998e1fff64ddf228a0] Background Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a well-known independent prognostic factor. However, the identification of occult tumour cells within the lymph nodes has remained a challenge for the pathologist as well as the clinician. Objective The aim of this study was to determine the prevalence of micrometastasis and isolated tumour cells (ITCs) in pathologically staged N0 OSCC of the tongue and buccal mucosa and to assess its correlation with vascular endothelial growth factor C, (VEGF-C) expressi... περισσότερα »
Range of pathologies diagnosed using a minimally invasive capsule sponge to evaluate patients with reflux symptoms
[image: cover.gif?v=1&s=7be473390ec332eac4bc1d6e] Abstract Aims Reflux symptoms are highly prevalent and non-specific hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non-endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms. Methods and Results Two complementary cohorts were recruited: 1) Patients with reflux symptoms and no prior endoscopy (n=409); 2) Patients with reflux symptoms referred for endoscopy (n=411). All pati... περισσότερα »
Reliability of histological grade in breast cancer core needle biopsies depends on biopsy size: a comparative study with subsequent surgical excisions
Abstract Background In breast cancer patients undergoing neoadjuvant chemotherapy, histologic grading needs to be done on core needle biopsies (CNB) that may not be representative of the whole tumour when they are small. Our aim was to study the influence of biopsy sizes on agreement rates of histological grade between CNB and subsequent surgical excision biopsies (SEB). Methods We calculated agreement and Cohen's κ between CNB and SEB of 300 early stage breast cancers. The number of cores, total core length, total tumour length and tumour: tissue ratio were assessed for each CNB... περισσότερα »
Efficiency calibration for in situ γ-ray measurements on the seabed using Monte Carlo simulations: Application in two different marine environments
[image: S0265931X.gif] Publication date: November 2016 *Source:*Journal of Environmental Radioactivity, Volume 164 Author(s): E.G. Androulakaki, C. Tsabaris, G. Eleftheriou, M. Kokkoris, D.L. Patiris, F.K. Pappa, R. Vlastou A new approach for calibrating an in situ detection system for measurements in marine sediments has been developed. The efficiency calibration was deduced on full spectral range by Monte Carlo simulations (MCNP5 code) considering a close detector-seabed geometry set-up. Moreover, the influence of the detection efficiency with respect to the variations of the sedi... περισσότερα »
Photoacoustic imaging for noninvasive monitoring of prostate cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
While active surveillance is often recommended for patients with nonaggressive prostate cancer to reduce unnecessary treatment, the challenge for clinicians is to monitor and distinguish early-stage tumours from advanced cancers. A team of scientists led… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29TEUQM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Researchers map molecular ‘social networks’ that drive breast cancer cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
A powerful new technology that maps the «social network» of proteins in breast cancer cells is providing detailed understanding of the disease at a molecular level and could eventually lead to new treatments, Australian scientists say. The technique -… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29CZ8dV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […]
Animal models of oncolytic virotherapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Cancer treatment in people could be transformed thanks to a study published in The Journal of Immunology on treating cancer in animals led by researchers from the Ontario Veterinary College (OVC) at the University of Guelph. Their findings in mice and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29TENVu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
Hormone signalling and inflammation of fat influnces breast cancer development
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
New research led by York University Professor Michael Connor highlights how fat cells could help determine the most effective way to fight breast cancer; including using exercise to combat the disease. The research published in the Journal of Applied… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29CYJIt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […]
Cancers, Vol. 8, Pages 67: Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the […]
The cost-effectiveness of #nivolumab improves by selecting non-squamous NSCLC PD-L1 patients: https://t.co/3yJKuTe4vf
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The cost-effectiveness of #nivolumab improves by selecting non-squamous NSCLC PD-L1 patients: https://t.co/3yJKuTe4vf from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753884354334584832 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
RT @Innovcancerinst : Dr. Amendola will be presenting at ecancer Colombia on Nov. 17 and 18! For more info visit https: //t.co/qomtYnca76 htt…
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
RT @Innovcancerinst : Dr. Amendola will be presenting at ecancer Colombia on Nov. 17 and 18! For more info visit https://t.co/qomtYnca76 htt… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753878642242031616 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Read our latest research paper to catch up on bladder preservation in non-metastatic muscle-invasive bladder cancer: https://t.co/LX1wkRWKzI
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Read our latest research paper to catch up on bladder preservation in non-metastatic muscle-invasive bladder cancer: https://t.co/LX1wkRWKzI from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753878216851456000 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
RT @EACRnews : Watch this video of EACR Secretary General Joan Seoane : https://t.co/y1sF4TKoCH
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
RT @EACRnews : Watch this video of EACR Secretary General Joan Seoane : https://t.co/y1sF4TKoCH from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753877976320712705 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Electrocardiography versus photoplethysmography in assessment of maternal heart rate variability during labor
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Evaluation of maternal heart rate (MHR) variability provides useful information on the maternal-fetal clinical state. Electrocardiography (ECG) is the most accurate method to monitor MHR but it may not always … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29BiOzE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Comparative study of case based learning with traditional teaching method in pharmacology for second year MBBS students
2016-07-15T02-37-37Z *Source:* International Journal of Basic & Clinical Pharmacology Srinivasa Kenchaiah, Purushotham Krishna. Background: Case based learning (CBL), a well known teaching- learning method, implemented by many especially in medical teaching is very useful. It helps learner to identify what they already know and to restructure, elaborate their knowledge and provide bridge between existing and new information. So this study was conducted to compare case based learning (CBL) over traditional teaching method (TTM) in pharmacology for second year MBBS students. Methods: CB... περισσότερα »
Proton pump inhibitors: are they safe on kidneys: a histopathological study
2016-07-15T02-37-37Z *Source:* International Journal of Basic & Clinical Pharmacology Ramachandra Prabhakar Limaye, Shabbir Rafik Pendhari, Kedar Shashikant Joshi. Background: In India the utilization of PPI varies to 45-85%. PPI were used in 82.96% patient with chronic kidney disease. But now a days several case reports are suggesting PPI induces AIN. The exact rate of this rare adverse event is difficult to estimate because many patients are taking multiple medications, which also make it difficult to establish a causal relation between AIN and PPI. Early detection of AIN and immedi... περισσότερα »
A drug utilization and pharmacoeconomic study of anti-diabetic drugs prescribed to type 2 diabetes mellitus patients visiting the medicine out-patient department of a tertiary care hospital of north India
2016-07-15T02-37-37Z *Source:* International Journal of Basic & Clinical Pharmacology Amandeep Singh, Shakti Bala Dutta, Amit Varma, Mirza Atif Beg, Hitender Kumar, Amanjot Kaur. Background: Type 2 diabetes mellitus (T2DM) patients require anti-diabetic drugs on chronic basis, frequent monitoring of blood glucose levels and a number of laboratory investigations, all of which result in significant economic burden on the diabetes patients and the world economies. The purpose of this study was to analyse the prescribing pattern to highlight the current approaches to the rational use of a... περισσότερα »
Cost-analysis study of second generation antihistamines used in the treatment of allergic rhinitis in India
2016-07-15T02-37-37Z *Source:* International Journal of Basic & Clinical Pharmacology Amandeep Singh, Hitender Kumar. Background: Second-generation antihistamines (SGAs) are the most commonly used drugs for AR nowadays. The cost of medicines is very important determinant in drug compliance; selection of low cost quality drugs would thus be helpful in improving compliance. Literature search revealed no such study done in India and the current study was thus planned to compare the variation in the cost of different SGAs used for the treatment of allergic rhinitis in India. The study res... περισσότερα »
Study of profile of poisoning cases reported to district hospital, Chamarajanagar, Karnataka, India
2016-07-15T02-37-37Z *Source:* International Journal of Basic & Clinical Pharmacology Srinivasa K., Yadukul S., Megha Madyastha. Background: Poisoning is a major public health problem worldwide, with thousands of deaths occurring every year, mainly in the developing countries. India, holding 70% of agricultural land, accounts for one third of pesticide poisoning cases in the third world, the farm workers being the worst affected. Most of the poisonings occur due to deliberate self-ingestion of the poison. Organo-phosphorus (OP) compounds occupy the greatest burden of poisoning related... περισσότερα »
Alcohol: is it detrimental to HIV infected individuals on antiretroviral therapy?
2016-07-15T01-08-21Z *Source:* International Journal of Research in Medical Sciences Kavita S. Joshi, Gajanan Chavan. Background: Chronic Alcohol consumption is immunosuppressant and HIV causes immunodeficiency. Both in same patient can have detrimental effect. HIV can progress rapidly in an alcoholic patient. This study is looking for adverse effects of alcoholism on CD4 response, adherence and adverse drug reactions on patients who are on highly active antiretroviral therapy. Methods: A prospective observational study done over period of one year after local institutional ethics com... περισσότερα »
A comparative study of ropivacaine 0.75% and bupivacaine 0.5% for segmental epidural anaesthesia in patients undergoing percutaneous nephrolithotomy
2016-07-15T01-08-21Z *Source:* International Journal of Research in Medical Sciences Mayur S. Ganvir, Geeta A. Patkar, Devangi A. Parikh, Bharati A. Tendolkar. Background: Percutaneous nephrolithotomy (PCNL) is used for fragmentation and removal of stones from pelvicalyceal system using a nephroscope passed into the kidneys through a track created in the patients back. PCNL is the treatment of choice for larger renal stones of size more than 20 to 30 mm, staghorn stones and stones that are multiple or resistant to extra corporeal shock. Methods: This prospective, randomized, open, cont... περισσότερα »
A study of comparing single dose granisetron with combination of granisetron with dexamethasone in preventing postoperative nausea vomiting in laparoscopic cholecystectomies
2016-07-15T01-08-21Z *Source:* International Journal of Research in Medical Sciences Dhawal R. Wadaskar, Jyoti S. Magar, Bharati A. Tendolkar. Background: Postoperative nausea and vomiting (PONV) remains a vexing problem despite of advances in anaesthesia care. PONV is distressing adverse effect after anaesthesia and surgery, resulting in significant morbidity due to acute discomfort associated with emetic symptoms and longer stays in the recovery room or unexpected hospital admission in ambulatory settings. Methods: A prospective, randomized, double blind comparative study was conduc... περισσότερα »
Excess deaths due to occupation
Harris *et al*1 provide useful new data for evaluating which occupational hazards are most deadly, and how this has changed over time. They have estimated excess deaths for different occupational groups, presumably exposed to specific hazards, via calculation of proportional mortality ratio (PMRs) (observed vs expected deaths) from death certificates, for causes of death strongly associated with occupations. Excess deaths (observed minus expected) over three study periods (1979–1990, 1991–2000 and 2001–2010) are presented (excess/observed deaths is the attributable fraction (AF) a... περισσότερα »
Simple benchmark for mesothelioma projection for Great Britain
Background It is of considerable interest to forecast the future burden of mesothelioma mortality. Data on deaths are available, whereas no measure of asbestos exposure is available. Methods We compare two Poisson models: a response-only model with an age-cohort specification and a multinomial model with epidemiologically motivated frequencies. Results The response-only model has 5% higher peak mortality than the dose–response model. The former performs slightly better in out-of-sample comparison. Conclusions Mortality is predicted to peak at about 2100 deaths around 2017 among... περισσότερα »
The global epidemic of chronic kidney disease: a call for action
While the Ebola and Zika viruses have made national and international headlines in recent months, another epidemic of larger magnitude is quietly devastating agricultural communities in developing countries worldwide. In Central America, the death toll from a mysterious type of chronic kidney disease (CKD) is estimated to be 20 000 in just 10 years.1 Unlike the CKD seen in developed countries, which is typically linked to hypertension and diabetes, this disease appears to be multifactorial and disproportionately afflicts young men of working age. In El Salvador, CKD is the second ... περισσότερα »
Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers
Objectives This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan. Methods We identified 95 workers of a printing company (78 men and 17 women) who had been exposed to 1,2-DCP between 1987 and 2006, and calculated the standardised incidence ratio (SIR) of cholangiocarcinoma from 1987 to 2012. We estimated cumulative exposure to 1,2-DCP and calculated SIRs in four exposure categories. We also cal... περισσότερα »
Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography
Objectives The aim of this study was to investigate whether shift work is related to elevated risk of coronary artery disease (CAD) by determining the coronary artery calcium (CAC) score and the presence of coronary artery stenosis by using coronary artery CT angiography (CCTA). Methods In this study, 110 male workers participated and underwent a CCTA examination for CAC scoring, which represents coronary artery plaque, and were evaluated for luminal stenosis. All of the participants were working in the same chemical plant, of whom 70 worked day shifts and 40 worked rotating shif... περισσότερα »
Shift work and coronary artery disease
The effect of shift work on the risk of coronary artery disease is uncertain. In their interesting study, Kang *et al*1 found an association between shift work and coronary artery atherosclerosis. The authors well assessed the outcome of the study. The study sample was, however, a small selected population. This study, in line with previous reports,23 found higher prevalence of cardiovascular risk factors in shift workers than in day workers. The unadjusted ORs, however, increased by 90% after controlling for eight confounding factors. OR increased from 1.77 (CI 0.73 to 4.23) to 3... περισσότερα »
Natural resource-based industries and prostate cancer risk in Northeastern Ontario: a case-control study
Objective Prostate cancer continues to be the most commonly diagnosed cancer in men, and there is limited knowledge on its preventable risk factors. A number of occupational exposures in natural resource-based industries are suspected to be related to prostate cancer risk. This study investigates associations between employment in these industries and prostate cancer. Methods Data were from a population-based, case–control study previously conducted in Northeastern Ontario. Incident cases (N=760) aged 45–85 years and diagnosed with prostate cancer between 1995 and 1998 were identi... περισσότερα »
Oxidative DNA damage during sleep periods among nightshift workers
Objectives Oxidative DNA damage may be increased among nightshift workers because of suppression of melatonin, a cellular antioxidant, and/or inflammation related to sleep disruption. However, oxidative DNA damage has received limited attention in previous studies of nightshift work. Methods From two previous cross-sectional studies, urine samples collected during a night sleep period for 217 dayshift workers and during day and night sleep (on their first day off) periods for 223 nightshift workers were assayed for 8-hydroxydeoxyguanosine (8-OH-dG), a marker of oxidative DNA damag... περισσότερα »
Job dissatisfaction and the older worker: baseline findings from the Health and Employment After Fifty study
Objectives Demographic changes are requiring people to work longer. Labour force participation might be promoted by tackling sources of job dissatisfaction. We aimed to describe the epidemiology of job dissatisfaction in older British workers, to explore which perceptions of work contribute most importantly, and to assess possible impacts on health. Methods Participants aged 50–64 years were recruited from 24 English general practices. At baseline, those currently in work (N=5437) reported on their demographic and employment circumstances, overall job satisfaction, perceptions of... περισσότερα »
Upper arm elevation and repetitive shoulder movements: a general population job exposure matrix based on expert ratings and technical measurements
[image: inline-graphic-1.gif] Objectives We recently constructed a general population job exposure matrix (JEM), The Shoulder JEM, based on expert ratings. The overall aim of this study was to convert expert-rated job exposures for upper arm elevation and repetitive shoulder movements to measurement scales. Methods The Shoulder JEM covers all Danish occupational titles, divided into 172 job groups. For 36 of these job groups, we obtained technical measurements (inclinometry) of upper arm elevation and repetitive shoulder movements. To validate the expert-rated job exposures agai... περισσότερα »
Night shift work and stomach cancer risk in the MCC-Spain study
Objectives Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case–control study. Methods A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain study. Detailed data on lifetime night shift work were collected including permanent and ro... περισσότερα »
Breast cancer among women in Michigan following exposure to brominated flame retardants
In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30 years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case–control study that included 51 women diagnosed with breast cancer during 1974–2004 and 20... περισσότερα »
Cancer mortality in a population exposed to nephrite processing
Objectives Although asbestos has been recognised as a strong carcinogen, many asbestos minerals exist in concrete masses, and the health risks of these materials remain inconclusive. Nephrite jade is a concrete mass of amphibole that consists of asbestiform and non-asbestiform particles. The objective of the study was to explore the carcinogenetic effect of nephrite. Methods We examined cancer mortality between 1979 and 2011 in Fengtian, where nephrite was mass produced from 1970 to 1980, and calculated standardised mortality ratios (SMRs). Results We observed significantly elev... περισσότερα »
Author response: Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography
We deeply appreciate the comments and suggestions from Rahman Shiri, MD, PhD. In South Korea, general health check-ups are performed by companies according to their labour management agreement. In this study, coronary artery CT angiography (CCTA) was the investigation specified by the labour management agreement. Prior to the test, the participants in this study were interviewed by a clinician. If the participants had any cardiovascular symptoms or a history of cardiovascular disease, they were transferred to specialist cardiology care and excluded from CCTA. Furthermore, the gene... περισσότερα »
Auditory Hallucination in Post Lingual Deaf Person: a Case Report
2016-07-15T00-52-32Z *Source:* Journal of Behavioral Health S.M. Yasir Arafat, Srijony Ahmed, MA Hamid. Evaluation of auditory hallucination in deaf person is a challenging task and there is paucity of standard procedure to evaluate. It was aimed at reporting a post lingual deaf patient with unique experience of auditory hallucination after a long period of not hearing any sound which made us difficult to evaluate. A 42 year old profoundly deaf male presented with hearing voices and persistent communication with that voices; sudden unprovoked aggression; undue suspiciousness; sleep di... περισσότερα »
The Association Between Demographic and Lifestyle Characteristics on Patient Cholesterol Profile
2016-07-15T00-52-32Z *Source:* Journal of Behavioral Health Elizabeth Crush, Paul D. Loprinzi. Purpose: Examine the association between demographic parameters, weight status and physical activity on patient cholesterol levels. Methods: Data from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) were used. Blood samples were used to evaluate LDL-cholesterol, HDL-cholesterol and triglycerides (TG). Body mass index was evaluated from measured height and weight, with physical activity evaluated via accelerometry. Multivariable logistic regression analysis was used to... περισσότερα »
Cross Cultural Adaptation and Psychometric Validation of Research Instruments: a Methodological Review
2016-07-15T00-52-32Z *Source:* Journal of Behavioral Health S.M. Yasir Arafat, Hafizur Rahman Chowdhury, MMA Salahuddin Qusar, M.A. Hafez. Background: Psychometrics has a very important role and with the increase in the number of cross cultural research projects, there is need to adapt the scales to measure the health status. Objective: It was aimed to describe the validation process comprehensively based on recent practices and to overview a practical guideline of validation study. Method: Search was done in PubMed, PubMed Central & Google Scholar with searching key words ranging da... περισσότερα »
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste http://ift.tt/29Vrzcp http://ift.tt/29H6fS1
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via xlomafota13 on Inoreader http://ift.tt/29Vrzcp via IFTTT http://ift.tt/29BjGnX
Prognostic significance of VEGF-C in predicting micrometastasis and isolated tumour cells in N0 oral squamous cell carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a well-known independent prognostic factor. However, the identification of occult tumour cells within the lymph nodes has remained a challenge for the pathologist as well as the clinician. Objective The aim of this study was to determine the prevalence of micrometastasis and isolated tumour […]
Half-life of IgE in the serum and the skin: Consequences for anti-IgE therapy in allergic disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Monica G. Lawrence, Judith A. Woodfolk, Alexander J. Schuyler, Leland C. Stillman, Martin D. Chapman, Thomas A.E. Platts-MillsWe present results from clinical studies on plasma infusion done in the late 1970s in patients with hypogammaglobulinemia, in which we documented the short half-life […]
Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: report of two siblings
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Johannes Trück, Dominic F. Kelly, John M. Taylor, Anne Kathrin Kienzler, Tracy Lester, Anneke Seller, Andrew J. Pollard, Smita Y. PatelWe describe the phenotype of 2 siblings with combined immunodeficiency due to CTPS1 deficiency and demonstrate the value of WES for rapid […]
Successful unrelated cord blood transplant for complete IFN-γR2 deficiency
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Camilia Kamoun, Megan Morsheimer, Kathleen E. Sullivan, Steven M. Holland, Charlotte Cunningham Rundles, Nancy Bunin, Jennifer R. Heimall Teaser We report a case of complete IFN-γR2 deficiency successfully treated with an unrelated cord blood transplant, which has yet to be described for […]
Pre-existing Anti-PEG Antibodies Are Associated with Severe Immediate Allergic Reactions to Pegnivacogin, a PEGylated Aptamer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Thomas J. Povsic, Monica G. Lawrence, A. Michael Lincoff, Roxana Mehran, Christopher P. Rusconi, Steven L. Zelenkofske, Zhen Huang, Jeff Sailstad, Paul W. Armstrong, P. Gabriel Steg, Christoph Bode, Richard C. Becker, John H. Alexander, N. Franklin Adkinson, Arnold I. Levinson Teaser […]
Vitamin D and antimicrobial peptide levels in patients with Atopic Dermatitis (AD) and Atopic Dermatitis complicated by Eczema Herpeticum (ADEH): A Pilot Study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Lujain H. Albenali, Simon Danby, Manar Moustafa, Kirsty Brown, John Chittock, Fiona Shackley, Michael J. Cork Teaser In this study, Vitamin D supplementation results in improved clinical severity of atopic dermatitis and increased skin surface LL-37 levels, analyzed by a novel, non-invasive […]
Clinical Trial Data Access – Opening Doors With TrialShare
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Adam L. Asare, Vincent J. Carey, Daniel Rotrosen, Gerald T. Nepom http://ift.tt/29HBbb4 http://ift.tt/29HZQbq
Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase δ syndrome–like immunodeficiency
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 14 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Yuki Tsujita, Kanako Mitsui-Sekinaka, Kohsuke Imai, Tzu-Wen Yeh, Noriko Mitsuiki, Takaki Asano, Hidenori Ohnishi, Zenichiro Kato, Yujin Sekinaka, Kiyotaka Zaha, Tamaki Kato, Tsubasa Okano, Takehiro Takashima, Kaoru Kobayashi, Mitsuaki Kimura, Tomoaki Kunitsu, Yoshihiro Maruo, Hirokazu Kanegane, Masatoshi Takagi, Kenichi Yoshida, Yusuke Okuno, […]
Three-dimensional assessment of crestal bone levels at titanium implants with different abutment microstructures and insertion depths using micro-computed tomography
Abstract Objectives To (i) assess the impact of insertion depth and abutment microstructure on the three-dimensional crestal bone-level changes at endosseous titanium implant using μCT and computerized image processing and (ii) to correlate the findings with previously reported histology. Material & Methods Titanium implants (conical abutment connection) were inserted in each hemimandible of *n* = 6 foxhounds with the implant shoulder (IS) located either in epicrestal (0 mm), supracrestal (+1 mm) or subcrestal (−1 mm) positions and randomly (split-mouth design) connected with mac... περισσότερα »
Three-dimensional assessment of crestal bone levels at titanium implants with different abutment microstructures and insertion depths using micro-computed tomography
Abstract Objectives To (i) assess the impact of insertion depth and abutment microstructure on the three-dimensional crestal bone-level changes at endosseous titanium implant using μCT and computerized image processing and (ii) to correlate the findings with previously reported histology. Material & Methods Titanium implants (conical abutment connection) were inserted in each hemimandible of *n* = 6 foxhounds with the implant shoulder (IS) located either in epicrestal (0 mm), supracrestal (+1 mm) or subcrestal (−1 mm) positions and randomly (split-mouth design) connected with machin... περισσότερα »
Prognostic significance of VEGF-C in predicting micrometastasis and isolated tumour cells in N0 oral squamous cell carcinoma
[image: cover.gif?v=1&s=fa071a998e1fff64ddf228a0] Background Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a well-known independent prognostic factor. However, the identification of occult tumour cells within the lymph nodes has remained a challenge for the pathologist as well as the clinician. Objective The aim of this study was to determine the prevalence of micrometastasis and isolated tumour cells (ITCs) in pathologically staged N0 OSCC of the tongue and buccal mucosa and to assess its correlation with vascular endothelial growth factor C, (VEGF-C) expression... περισσότερα »
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via xlomafota13 on Inoreader http://ift.tt/29Vrzcp via IFTTT
Spontaneous, synchronized, and corrective timing behavior in cerebellar lesion patients
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Michael Schwartze, Peter E. Keller, Sonja A. Kotz To successfully navigate through and interact with a dynamic environment it is necessary to acquire and use adequate temporal information to guide behavior. Apart from several areas in the cerebral cortex and cortico-striatal networks, the cerebellum has been proposed to engage in the processing of temporal information. Damage to the cerebellum can impair precise event-based temporal processing in motor and non-motor beha... περισσότερα »
Parameters for abolishing conditioned place preference for cocaine from running and environmental enrichment in male C57BL/6J mice
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): M.L. Mustroph, H. Pinardo, J.R. Merritt, J.S. Rhodes RationaleEvidence suggests that 4 weeks of voluntary wheel running abolishes conditioned place preference (CPP) for cocaine in male C57BL/6J mice.ObjectivesTo determine the duration and timing of exposure to running wheels necessary to reduce CPP, and the extent to which the running per se influences CPP as compared to environmental enrichment without running.MethodsA total of 239 males were conditioned for 4days twice... περισσότερα »
Effect of heading perception on microsaccade dynamics
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Alessandro Piras, Milena Raffi, Michela Persiani, Monica Perazzolo, Salvatore Squatrito The present study shows the relationship between microsaccades and heading perception. Recent research demonstrates that microsaccades during fixation are necessary to overcome loss of vision due to continuous stimulation of the retinal receptors, even at the potential cost of a decrease in visual acuity. The goal of oculomotor fixational mechanisms might be not retinal stabilization... περισσότερα »
Neuroinflammatory response to experimental stroke is inhibited by eriodictyol
Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Emerson de Oliveira Ferreira, Mara Yone Soares Dias Fernandes, Neila Maria Rocha de Lima, Kelly Rose Tavares Neves, Marta Regina Santos do Carmo, Francisco Arnaldo Viana Lima, Analu Aragão Fonteles, Ana Paula Fontenele Menezes, Geanne Matos de Andrade BackgroundCerebral ischemia is a common disease and one of the most common causes of death and disability worldwide. The lack of glucose and oxygen in neuronal tissue leads to a series of inflammatory events, culminating in neuronal death. Eriod... περισσότερα »
Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Laura C. Fox, Daniel R. Davies, Jamie L. Scholl, Michael J. Watt, Gina L. Forster Mild traumatic brain injuries (TBIs) comprise three-quarters of all TBIs occurring in the United States annually, and psychological symptoms arising from them can last years after injury. One commonly observed symptom following mild TBI is generalized anxiety. Most mild TBIs happen in stressful situations (sports, war, domestic violence, etc.) when glucocorticoids are elevated in the brain... περισσότερα »
Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Shih-hsin Kan, Steven Q. Le, Quang D. Bui, Braeden Benedict, Jesse Cushman, Mark S. Sands, Patricia I. Dickson Sanfilippo B syndrome is a progressive neurological disorder caused by inability to catabolize heparan sulfate glycosaminoglycans. We studied neurobehavior in male Sanfilippo B mice and heterozygous littermate controls from 16 to 20 weeks of age. Affected mice showed reduced anxiety, with a decrease in the number of stretch-attend postures during the elevated p... περισσότερα »
Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Connor Thelen, Jonathon Sens, Joseph Mauch, Radhika Pandit, Pothitos M. Pitychoutis One of the most striking discoveries in the treatment of major depression was the finding that infusion of a single sub-anesthetic dose of ketamine induces rapid and sustained antidepressant effects in treatment-resistant depressed patients. However, ketamine's antidepressant-like actions are transient and can only be sustained by repeated drug treatment. Despite the fact that women expe... περισσότερα »
Significance of sniffing pattern during the acquisition of an olfactory discrimination task
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Laura Lefèvre, Emmanuelle Courtiol, Samuel Garcia, Marc Thévenet, Belkacem Messaoudi, Nathalie Buonviso Active sampling of olfactory environment consists of sniffing in rodents. The importance of sniffing dynamics is well established at the neuronal and behavioral levels. Patterns of sniffing have been shown to be modulated by the physicochemical properties of odorants, particularly concentration and sorption. Sniffing is also heavily impacted by higher processing relate... περισσότερα »
Sexual dimorphisms in swimming behavior, cerebral metabolic activity and adrenoceptors in adult zebrafish (Danio rerio)
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Konstantinos Ampatzis, Catherine R. Dermon Sexually dimorphic behaviors and brain sex differences, not only restricted to reproduction, are considered to be evolutionary preserved. Specifically, anxiety related behavioral repertoire is suggested to exhibit sex-specific characteristics in rodents and primates. The present study investigated whether behavioral responses to novelty, have sex-specific characteristics in the neurogenetic model organism zebrafish (Danio rerio)... περισσότερα »
Posture-related changes in brain functional connectivity as assessed by wavelet phase coherence of NIRS signals in elderly subjects
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Bitan Wang, Ming Zhang, Lingguo Bu, Liwei Xu, Wei Wang, Zengyong Li Postural instability and falls are commonly seen because of aging and motor disabilities. This study aims to assess the posture-related changes in brain functional connectivity by wavelet phase coherence (WPCO) of oxyhemoglobin concentration change (Δ[HbO2]) signals measured through near-infrared spectroscopy (NIRS) in elderly subjects. The NIRS signals were continuously recorded from the prefrontal cor... περισσότερα »
Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Laura Feldcamp, Jean-Sebastien Doucet, Judy Pawling, Marc P. Fadel, Paul J. Fletcher, Robert Maunder, James W. Dennis, Albert H.C. Wong Psychosocial adversity in early life increases the likelihood of mental and physical illness, but the underlying mechanisms are poorly understood. Mgat5 is an N-acetylglucosaminyltransferase in the Golgi pathway that remodels the N-glycans of glycoproteins at the cell surface. Mice lacking Mgat5 display conditional phenotypes in behaviou... περισσότερα »
Prior alcohol consumption does not impair go/no-go discrimination learning, but causes over-responding on go trials, in rats
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Charles L. Pickens, Hayley Fisher, Nicholas Bright, Mark Gallo, Madelyn H. Ray, Antje Anji, Meena Kumari Prior alcohol use is associated with impaired response inhibition in humans, including in laboratory go/no-go discrimination tasks. In two experiments, we determined whether chronic intermittent access to alcohol would alter go/no-go discrimination learning. Rats received 4–6 weeks of chronic intermittent access to 20% alcohol (alone or accompanied by saline or 1.5g/... περισσότερα »
Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R. Freeman High fat diets have detrimental effects on cognitive performance, and can increase oxidative stress and inflammation in the brain. The aging brain provides a vulnerable environment to which a high fat diet could cause more damage. We investigated the effects of a high fat/high cholesterol (HFHC) diet on cognitive performance, neuroinflammation markers, and phosphorylated Tau (p... περισσότερα »
Involvement of glutamatergic N-methyl-d-aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Noritaka Hirose, Akiyoshi Saitoh, Junzo Kamei Olfactory bulbectomized (OB) mice produce agitated anxiety-like behaviors in the hole-board test, which was expressed by an increase in head-dipping counts and a decrease in head-dipping latencies. However, the associated mechanisms remain unclear. In the present study, MK-801 (10, 100μg/kg), a selective N-methyl-d-aspartate (NMDA) receptor antagonist, significantly and dose-dependently suppressed the increased head-dipping b... περισσότερα »
Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD)
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Elizabeth Watterson, Alexander Spitzer, Lucas R. Watterson, Ryan J. Brackney, Arturo R. Zavala, M. Foster Olive, Federico Sanabria Attention deficit hyperactivity disorder (ADHD) is associated with increased risk of tobacco dependence. Nicotine, the main psychoactive component of tobacco, appears to be implicated in ADHD-related tobacco dependence. However, the behavioral responsiveness to nicotine of the prevalent animal model of ADHD, the spontaneously hypertensive rat... περισσότερα »
The brain structure and spontaneous activity baseline of the behavioral bias in trait anxiety
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Ping Yin, Meng Zhang, Xin Hou, Yafei Tan, Yixiao Fu, Jiang Qiu Individuals with trait anxiety are often considered to be predisposed to psychiatric disorders. However, there is great heterogeneity in the development of psychiatric disorders in this group of people and the nature of the trait anxiety is still unclear. So, we decided to explore the correlations of brain structure and brain activity with trait anxiety in normal individuals. Specifically, we investigated the... περισσότερα »
Mouse model of intracerebellar haemorrhage
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Abubakar Tijjani Salihu, Sangu Muthuraju, Abdul Aziz Mohamed Yusoff, Farizan Ahmad, Mohd Zulkifli Mustafa, Hasnan Jaafar, Zamzuri Idris, Abdul Rahman Izaini Ghani, Jafri Malin Abdullah The present study aimed to investigate the behavior and neuronal morphological changes in the perihaemorrhagic tissue of the mouse intracerebellar haemorrhage experimental model. Adult male Swiss albino mice were stereotactically infused with collagenase type VII (0.4U/μl of saline) unila... περισσότερα »
Theta-band oscillatory activity differs between gamblers and nongamblers comorbid with attention-deficit hyperactivity disorder in a probabilistic reward-learning task
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Mehdi Abouzari, Scott Oberg, Matthew Tata Problemgambling is thought to be comorbid with attention-deficit hyperactivity disorder (ADHD). We tested whether gamblers and ADHD patients exhibit similar reward-related brain activity in response to feedback in a gambling task. A series of brain electrical responses can be observed in the electroencephalogram (EEG) and the stimulus-locked event-related potentials (ERP), when participants in a gambling task are given feedback ... περισσότερα »
Associative learning in the multichamber tank: A new learning paradigm for zebrafish
[image: alertIcon.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Yohaan M. Fernandes, Mindy Rampersad, Ana C. Luchiari, Robert Gerlai The zebrafish has been gaining prominence in the field of behavioural brain research as this species offers a good balance between system complexity and practical simplicity. While the number of studies examining the behaviour of zebrafish has exponentially increased over the past decade, the need is still substantial for paradigms capable of assessing cognitive and mnemonic characteristics of this spe... περισσότερα »
Motor planning in different grasping tasks by capuchin monkeys (Sapajus spp.)
[image: S01664328.gif] Publication date: 1 October 2016 *Source:*Behavioural Brain Research, Volume 312 Author(s): Gloria Sabbatini, Giusy Meglio, Valentina Truppa Studies on motor planning and action selection in object use reveal that what we choose to do in the present moment depends on our next planned action. In particular, many studies have shown that adult humans initially adopt uncomfortable hand postures to accommodate later task demands (i.e., the end-state comfort effect). Recent studies on action planning in different non-human primates species have provided contrasting r... περισσότερα »
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via xlomafota13 on Inoreader http://ift.tt/29Vrzcp via IFTTT
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via ola Kala on Inoreader http://ift.tt/29Vrzcp via IFTTT
Letter to the editor: Whole scalp EEG power change is not a prerequisite for further EEG processing
[image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Hearing Research Author(s): Dirk De Ridder, Marco Congedo, Jae-Jin Song, Sven Vanneste from #Audiology via ola Kala on Inoreader http://ift.tt/29Vrzcp via IFTTT
Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases
Summary Background Personalised medicine, including biomarkers for treatment selection, may provide new algorithms for more effective treatment of patients. Genetic variation may impact drug response and genetic markers could help selecting the best treatment strategy for the individual patient. Aim To identify polymorphisms and candidate genes from the literature that are associated with anti-tumour necrosis factor (TNF) treatment response in patients with inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis. Methods We performed a PubMed literature s... περισσότερα »
HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients
Summary Background Eradication of hepatitis C virus (HCV) is increasing but its residual impact on the pro-inflammatory milieu in cirrhosis, which is associated with gut dysbiosis, is unclear. Aim To define the impact of sustained virological response (SVR) on gut dysbiosis and systemic inflammation in HCV cirrhosis patients. Methods Cirrhotic out-patients with HCV with/without SVR (achieved >1 year prior) and age-matched healthy controls underwent serum and stool collection. Serum was analysed for IL-6, TNF-α and endotoxin while stool microbiota analysis was performed using mu... περισσότερα »
Excess deaths due to occupation
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Harris *et al*1 provide useful new data for evaluating which occupational hazards are most deadly, and how this has changed over time. They have estimated excess deaths for different occupational groups, presumably exposed to specific hazards, via calculation of proportional mortality ratio (PMRs) (observed vs expected deaths) from death certificates, for causes of death strongly associated with occupations. Excess deaths (observed minus expected) over three study periods (1979–1990, 1991–2000 and 2001–2010) are presented (excess/observed deaths is the attributable fraction (AF) a... περισσότερα »
Simple benchmark for mesothelioma projection for Great Britain
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Background It is of considerable interest to forecast the future burden of mesothelioma mortality. Data on deaths are available, whereas no measure of asbestos exposure is available. Methods We compare two Poisson models: a response-only model with an age-cohort specification and a multinomial model with epidemiologically motivated frequencies. Results The response-only model has 5% higher peak mortality than the dose–response model. The former performs slightly better in out-of-sample comparison. Conclusions Mortality is predicted to peak at about 2100 deaths around 2017 among... περισσότερα »
The global epidemic of chronic kidney disease: a call for action
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
While the Ebola and Zika viruses have made national and international headlines in recent months, another epidemic of larger magnitude is quietly devastating agricultural communities in developing countries worldwide. In Central America, the death toll from a mysterious type of chronic kidney disease (CKD) is estimated to be 20 000 in just 10 years.1 Unlike the CKD seen in developed countries, which is typically linked to hypertension and diabetes, this disease appears to be multifactorial and disproportionately afflicts young men of working age. In El Salvador, CKD is the second ... περισσότερα »
Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan. Methods We identified 95 workers of a printing company (78 men and 17 women) who had been exposed to 1,2-DCP between 1987 and 2006, and calculated the standardised incidence ratio (SIR) of cholangiocarcinoma from 1987 to 2012. We estimated cumulative exposure to 1,2-DCP and calculated SIRs in four exposure categories. We also cal... περισσότερα »
Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives The aim of this study was to investigate whether shift work is related to elevated risk of coronary artery disease (CAD) by determining the coronary artery calcium (CAC) score and the presence of coronary artery stenosis by using coronary artery CT angiography (CCTA). Methods In this study, 110 male workers participated and underwent a CCTA examination for CAC scoring, which represents coronary artery plaque, and were evaluated for luminal stenosis. All of the participants were working in the same chemical plant, of whom 70 worked day shifts and 40 worked rotating shif... περισσότερα »
Shift work and coronary artery disease
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
The effect of shift work on the risk of coronary artery disease is uncertain. In their interesting study, Kang *et al*1 found an association between shift work and coronary artery atherosclerosis. The authors well assessed the outcome of the study. The study sample was, however, a small selected population. This study, in line with previous reports,23 found higher prevalence of cardiovascular risk factors in shift workers than in day workers. The unadjusted ORs, however, increased by 90% after controlling for eight confounding factors. OR increased from 1.77 (CI 0.73 to 4.23) to 3... περισσότερα »
Natural resource-based industries and prostate cancer risk in Northeastern Ontario: a case-control study
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objective Prostate cancer continues to be the most commonly diagnosed cancer in men, and there is limited knowledge on its preventable risk factors. A number of occupational exposures in natural resource-based industries are suspected to be related to prostate cancer risk. This study investigates associations between employment in these industries and prostate cancer. Methods Data were from a population-based, case–control study previously conducted in Northeastern Ontario. Incident cases (N=760) aged 45–85 years and diagnosed with prostate cancer between 1995 and 1998 were identi... περισσότερα »
Oxidative DNA damage during sleep periods among nightshift workers
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives Oxidative DNA damage may be increased among nightshift workers because of suppression of melatonin, a cellular antioxidant, and/or inflammation related to sleep disruption. However, oxidative DNA damage has received limited attention in previous studies of nightshift work. Methods From two previous cross-sectional studies, urine samples collected during a night sleep period for 217 dayshift workers and during day and night sleep (on their first day off) periods for 223 nightshift workers were assayed for 8-hydroxydeoxyguanosine (8-OH-dG), a marker of oxidative DNA damag... περισσότερα »
Job dissatisfaction and the older worker: baseline findings from the Health and Employment After Fifty study
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives Demographic changes are requiring people to work longer. Labour force participation might be promoted by tackling sources of job dissatisfaction. We aimed to describe the epidemiology of job dissatisfaction in older British workers, to explore which perceptions of work contribute most importantly, and to assess possible impacts on health. Methods Participants aged 50–64 years were recruited from 24 English general practices. At baseline, those currently in work (N=5437) reported on their demographic and employment circumstances, overall job satisfaction, perceptions of... περισσότερα »
Upper arm elevation and repetitive shoulder movements: a general population job exposure matrix based on expert ratings and technical measurements
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: inline-graphic-1.gif] Objectives We recently constructed a general population job exposure matrix (JEM), The Shoulder JEM, based on expert ratings. The overall aim of this study was to convert expert-rated job exposures for upper arm elevation and repetitive shoulder movements to measurement scales. Methods The Shoulder JEM covers all Danish occupational titles, divided into 172 job groups. For 36 of these job groups, we obtained technical measurements (inclinometry) of upper arm elevation and repetitive shoulder movements. To validate the expert-rated job exposures agai... περισσότερα »
Night shift work and stomach cancer risk in the MCC-Spain study
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case–control study. Methods A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain study. Detailed data on lifetime night shift work were collected including permanent and ro... περισσότερα »
Breast cancer among women in Michigan following exposure to brominated flame retardants
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30 years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case–control study that included 51 women diagnosed with breast cancer during 1974–2004 and 20... περισσότερα »
Cancer mortality in a population exposed to nephrite processing
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives Although asbestos has been recognised as a strong carcinogen, many asbestos minerals exist in concrete masses, and the health risks of these materials remain inconclusive. Nephrite jade is a concrete mass of amphibole that consists of asbestiform and non-asbestiform particles. The objective of the study was to explore the carcinogenetic effect of nephrite. Methods We examined cancer mortality between 1979 and 2011 in Fengtian, where nephrite was mass produced from 1970 to 1980, and calculated standardised mortality ratios (SMRs). Results We observed significantly elev... περισσότερα »
Author response: Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
We deeply appreciate the comments and suggestions from Rahman Shiri, MD, PhD. In South Korea, general health check-ups are performed by companies according to their labour management agreement. In this study, coronary artery CT angiography (CCTA) was the investigation specified by the labour management agreement. Prior to the test, the participants in this study were interviewed by a clinician. If the participants had any cardiovascular symptoms or a history of cardiovascular disease, they were transferred to specialist cardiology care and excluded from CCTA. Furthermore, the gene... περισσότερα »
Linear transformation of the encoding mechanism for light-intensity underlies the paradoxical enhancement of cortical visual responses by sevoflurane
Abstract General anaesthetics, which are expected to silence brain activity, often spare sensory responses. To evaluate differential effects of anaesthetics on spontaneous and sensory-evoked cortical activity, we characterized their modulation by sevoflurane and propofol. Power spectra and bust-suppression ratio from EEG data were used to evaluate anaesthesia depth. ON and OFF cortical responses were elicited by light-pulses of variable intensity, duration and frequency, during light and deep states of anaesthesia. Both anaesthetics reduced spontaneous cortical activity but sevoflur... περισσότερα »
Potential mediators linking gut bacteria to metabolic health: a critical view
Abstract Growing evidence suggests that the bacteria present in our gut may play a role in mediating the effect of genetics and lifestyle on obesity and metabolic diseases. Most of the current literature on gut bacteria consists of cross-sectional and correlative studies, rendering it difficult to make any causal inferences as to the influence of gut bacteria on obesity and related metabolic disorders. Interventions with germ-free animals, treatment with antibiotic agents, and microbial transfer experiments have provided some evidence that disturbances in gut bacteria may causally ... περισσότερα »
Somatosensory temporal discrimination threshold in Parkinson’s disease parallels disease severity and duration
[image: S13882457.gif] Publication date: Available online 5 July 2016 *Source:*Clinical Neurophysiology Author(s): Antonella Conte, Giorgio Leodori, Gina Ferrazzano, Maria I. De Bartolo, Nicoletta Manzo, Giovanni Fabbrini, Alfredo Berardelli ObjectiveTo investigate whether the somatosensory temporal discrimination threshold (STDT) is already altered at the clinical onset of Parkinson’s disease (PD) and whether STDT abnormalities correlate with disease progression we tested STDT values in patients with different severity of disease.Methodswe prospectively and consecutively enrolled 63... περισσότερα »
In memoriam: Professor Irena Hausmanowa-Petrusewicz (1917–2015)
[image: alertIcon.gif] Publication date: Available online 9 July 2016 *Source:*Clinical Neurophysiology Author(s): Ewa Zalewska from Physiology via xlomafota13 on Inoreader http://ift.tt/29Iz9lQ
Predictive role of brain connectivity for resective surgery in Lennox–Gastaut syndrome
[image: S13882457.gif] Publication date: August 2016 *Source:*Clinical Neurophysiology, Volume 127, Issue 8 Author(s): Yun Jung Hur, Heung Dong Kim ObjectiveCallosotomy can reveal hidden primary epileptogenic areas in Lennox–Gastaut syndrome (LGS). We studied the significance of causal connectivity for identifying hidden epileptogenic areas in preoperative electroencephalography (EEG) and for making a decision regarding resective surgery.MethodsWe enrolled 18 LGS patients who underwent corpus callosotomy. Eight patients with unilateral epileptogenicity on post-callosotomy EEG underw... περισσότερα »
Single and paired pulse transcranial magnetic stimulation in drug naïve epilepsy
[image: S13882457.gif] Publication date: Available online 5 July 2016 *Source:*Clinical Neurophysiology Author(s): Annika A. de Goede, Esther M. ter Braack, Michel J.A.M. van Putten Transcranial magnetic stimulation (TMS) measures cortical excitability, and is therefore potentially suitable as an additional tool for epilepsy diagnostics and therapy evaluation. In this review we discuss the application of TMS in epilepsy research and systematically analyze single and paired pulse TMS outcomes from 31 drug naïve patient studies.Despite a large variety in used TMS protocols, there was ... περισσότερα »
Electrophysiological correlates of word recognition memory process in patients with ischemic left ventricular dysfunction
[image: S13882457.gif] Publication date: Available online 11 July 2016 *Source:*Clinical Neurophysiology Author(s): Fabio Giovannelli, David Simoni, Gioele Gavazzi, Fiorenza Giganti, Iacopo Olivotto, Massimo Cincotta, Alessandra Pratesi, Samuele Baldasseroni, Maria Pia Viggiano ObjectiveThe relationship between left ventricular ejection fraction (LVEF) and cognitive performance in patients with coronary artery disease without overt heart failure is still under debate. In this study we combine behavioural measures and event-related potentials (ERPs) to verify whether electrophysiolog... περισσότερα »
Late and progressive alterations of sleep dynamics following central thalamic deep brain stimulation (CT-DBS) in chronic minimally conscious state
[image: alertIcon.gif] Publication date: Available online 9 July 2016 *Source:*Clinical Neurophysiology Author(s): Zoe M. Adams, Peter B. Forgacs, Mary M. Conte, Tanya J. Nauvel, Jonathan D. Drover, Nicholas D. Schiff from Physiology via xlomafota13 on Inoreader http://ift.tt/29IyNM1
Abnormal resting-state brain activity in headache-free migraine patients: A magnetoencephalography study
[image: S13882457.gif] Publication date: August 2016 *Source:*Clinical Neurophysiology, Volume 127, Issue 8 Author(s): Feng Li, Jing Xiang, Ting Wu, Donglin Zhu, Jingping Shi ObjectiveThe aim of this study is to quantitatively assess the resting-state brain activity in migraine patients during the headache-free phase with magnetoencephalography (MEG).MethodsA total of 25 migraine patients during the headache-free phase and 25 gender- and age-matched control patients were studied with a whole-head MEG system at eyes-closed resting-state. MEG data were analyzed in multifrequency range ... περισσότερα »
A unified statistical model for the human electrocorticogram
[image: S13882457.gif] Publication date: Available online 5 July 2016 *Source:*Clinical Neurophysiology Author(s): Giridhar P. Kalamangalam, Mircea I. Chelaru, Jeremy D. Slater ObjectiveExtracellular field potentials (ECFs) generated in the cerebral cortex span a vast range of spatiotemporal scales. The process(es) leading to this large dynamic range remain debatable. Here we propose a novel statistical description of the amplitude spectrum of the human electrocorticogram (ECoG).MethodsSpectral analysis was performed on long-term recordings from epilepsy patients undergoing pre-surgi... περισσότερα »
Graph Analysis of EEG Resting State Functional Networks in Dyslexic Readers
Publication date: Available online 4 July 2016 *Source:*Clinical Neurophysiology Author(s): G. Fraga González, M.J.W. Van der Molen, G. Žarić, M. Bonte, J. Tijms, L. Blomert, C.J. Stam, M.W. Van der Molen ObjectiveNeuroimaging research suggested a mixed pattern of functional connectivity abnormalities in developmental dyslexia. We examined differences in the topological properties of functional networks between 29 dyslexics and 15 typically reading controls in 3rd grade using graph analysis. Graph metrics characterize brain networks in terms of integration and segregation.MethodWe use... περισσότερα »
