Topography of the coracobrachialis muscle and the musculocutaneous nerve by muscular variation
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/29mBOlw via IFTTT
Preclinical study of CE7-CAR T cell therapy in neuroblastoma
Purpose: The identification and vetting of cell surface tumor restricted epitopes for chimeric antigen receptor (CAR) redirected T cell immunotherapy is the subject of intensive investigation. We have focused on CD171 (L1-CAM), an abundant cell surface molecule on neuroblastomas and, specifically, on the glycosylation dependent tumor-specific epitope recognized by the CE7 monoclonal antibody. Experimental Design: CD171 expression was assessed by IHC using CE7 mAb in tumor microarrays of primary, metastatic, and recurrent neuroblastoma, as well as human and rhesus macaque tissue ar... περισσότερα »
Oncolytic virus therapy in conjunction with bortezomib
Background: Both the proteasome inhibitor bortezomib and an oncolytic herpes simplex virus-1 (oHSV) expressing GMCSF are currently FDA-approved. While proteasome blockade can increase oHSV replication, immunological consequences and consequent immunotherapy potential are unknown. In this study, we investigated the impact of bortezomib combined with oHSV on tumor cell death and sensitivity to Natural Killier (NK) cell immunotherapy. Experimental Design: Western blot, flow cytometry, and caspase 3/7 activity assays were used to evaluate the induction of apoptosis/autophagy and/or ne... περισσότερα »
Mutational Landscape and Immunity in Cancer
Immunotherapy is currently transforming cancer treatment. Notably, immune checkpoint blockers (ICB) have shown unprecedented therapeutic successes in numerous tumor types, including cancers that were traditionally considered as non-immunogenic. However, a significant proportion of patients do not respond to these therapies. Thus, early selection of the most sensitive patients is key, and the development of predictive companion biomarkers constitutes one of the biggest challenges of ICB development. Recent publications have suggested that the tumor genomic landscape, mutational loa... περισσότερα »
Quadruple-negative GIST is a sentinel for NF1 syndrome
Purpose: The majority of Gastrointestinal Stromal Tumors (GISTs) are driven by KIT, PDGFRA or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited fraction of gastric lesions. However, about 10% of GISTs are devoid of any of such alterations and are poorly responsive to standard treatments. This study aims to shed light on the molecular drivers of quadruple-negative GISTs. Experimental Design: Twenty-two sporadic quadruple-negative GISTs with no prior association with Neurofibromatosis Type 1 syndrome were molecularly profiled for a panel of genes belo... περισσότερα »
Management of women with a hereditary predisposition for breast cancer
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/29uRRAe via IFTTT
Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study
*Purpose*. So-called spontaneous remissions in cancer often seem to occur after febrile events. Mistletoe preparations (MPs) are used off-label intravenously to induce fever within concepts of integrative oncology. We wanted to investigate the frequency of febrile reactions and safety related to intravenously applied MPs (IAMPs). *Methods*. This was a retrospective analysis of data from consecutive cancer patients who were treated in 2 anthroposophic hospitals with IAMPs. The main outcome parameter was the rate of core temperature increase to ≥38.5°C within 24 hours after IAMPs. S... περισσότερα »
Dopamine in plasma – a biomarker for myofascial TMD pain?
Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD a... from #Neuroscience via alexandrossfakianakis on Inoreader http://ift.tt/29CT2gd via IFTTT
What is the publication rate for presentations given at the British Academic Conference in Otolaryngology (BACO)?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
What is the publication rate for presentations given at the British Academic Conference in Otolaryngology (BACO)?: Abstract Introduction The publication rate of some large academic meetings such as the American Academy of Otolaryngology-Head and Neck Surgery has been reported as 32%. We aimed to compare the rate of publication at the British Academic Conference in […]
Adaptation of the MacArthur-Bates Communicative Development Inventories for Spanish Children With Down Syndrome: Validity and Reliability Data for Vocabulary
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Adaptation of the MacArthur-Bates Communicative Development Inventories for Spanish Children With Down Syndrome: Validity and Reliability Data for Vocabulary: Purpose The MacArthur-Bates Communicative Development Inventories are widely used to study early language and communicative development. We recently developed a Spanish version for children with Down syndrome (the CDI-Down) adapted to their particular profile of linguistic […]
Sentence Processing in Traumatic Brain Injury: Evidence From the P600
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Sentence Processing in Traumatic Brain Injury: Evidence From the P600: Purpose Sentence processing can be affected following a traumatic brain injury (TBI) due to linguistic or cognitive deficits. Language-related event-related potentials (ERPs), particularly the P600, have not been described in individuals with TBI history. Method Four young adults with a history of closed head injury […]
Pantomime Production by People With Aphasia: What Are Influencing Factors?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Pantomime Production by People With Aphasia: What Are Influencing Factors?: Purpose The present article aimed to inform clinical practice on whether people with aphasia (PWA) deploy pantomime techniques similarly to participants without brain damage (PWBD) and if not, what factors influence these differences. Method We compared 38 PWA to 20 PWBD in their use of […]
Mandarin Lexical Tone Acquisition in Cochlear Implant Users With Prelingual Deafness: A Review
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Mandarin Lexical Tone Acquisition in Cochlear Implant Users With Prelingual Deafness: A Review: Purpose The purpose of this review article is to synthesize evidence from the fields of developmental linguistics and cochlear implant technology relevant to the production and perception of Mandarin lexical tone in cochlear implant users with prelingual deafness. The aim of this […]
Acoustic–Phonetic Versus Lexical Processing in Nonnative Listeners Differing in Their Dominant Language
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Acoustic–Phonetic Versus Lexical Processing in Nonnative Listeners Differing in Their Dominant Language: Purpose Nonnative listeners have difficulty recognizing English words due to underdeveloped acoustic–phonetic and/or lexical skills. The present study used Boothroyd and Nittrouer’s (1988) j factor to tease apart these two components of word recognition. Method Participants included 15 native English and 29 native […]
No Association Was Found Between Maternal Exposures to Persistent Organic Pollutants, Infant Thyroid Function, and Birth Outcomes
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
No Association Was Found Between Maternal Exposures to Persistent Organic Pollutants, Infant Thyroid Function, and Birth Outcomes: Clinical Thyroidology Jul 2016, Vol. 28, No. 7: 211-213. http://ift.tt/29uTVbe
Patients with TSH-Receptor Blocking Antibodies Give a “Positive” Result for Stimulating Activity in Several Commercial Assays
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Patients with TSH-Receptor Blocking Antibodies Give a “Positive” Result for Stimulating Activity in Several Commercial Assays: Clinical Thyroidology Jul 2016, Vol. 28, No. 7: 206-207. Author information Stephen W. Spaulding Diana T, Wüster C, Kanitz M, Kahaly GJ. Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies. J Endocrinol Invest. May 19, […]
Use of Genetic Markers May Prevent Antithyroid Drug–Induced Agranulocytosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
• Clinical Thyroidology July 2016, Vol. 28, No. 7, 203-205 Posted online on July 7, 2016. (doi:10.1089/ct.2016;28.203-205) View Table of Contents | TOC, Citation What is RSS? | Email Alert Author information Tim I. M. Korevaar Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, Carvajal A, Lucena MI, Ponce ES, Molokhia M, Martin J, Axelsson T, Yue Q, Magnusson PKE, […]
The Poor Health-Related Quality of Life Associated with Hypothyroidism
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
• Is Not Completely Reversed by 6 Months of Levothyroxine Treatment Clinical Thyroidology July 2016, Vol. 28, No. 7, 200-202 Posted online on July 7, 2016. (doi:10.1089/ct.2016;28.200-202) View Table of Contents | TOC, Citation What is RSS? | Email Alert Author information Elizabeth N. Pearce Winther KH, Cramon P, Watt T, Bjorner JB, Ekholm O, Feldt-Rasmussen U, Groenvold M, Rasmussen ÅK, Hegedüs […]
High potential for weathering and climate effects of non-vascular vegetation in the Late Ordovician
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Article Early non-vascular vegetation may have caused an interval of glaciations in the Late Ordovician by enhancing global chemical weathering. Here, by simulating the organisms with a spatially explicit, process-based model, the authors propose that Ordovician vegetation had a high potential for chemical weathering. Nature Communications doi: 10.1038/ncomms12113 Authors: P. Porada, T. M. Lenton, A. […]
Thermodynamics of quantum systems with multiple conserved quantities
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Article The second law of thermodynamics constrains how much of a conserved quantity, such as energy, can be extracted from a system in the form of work. Here, the authors generalize this law to quantum systems whose conserved quantities need not commute, showing that it is their combination to be constrained. Nature Communications doi: 10.1038/ncomms12049 […]
aMAP is a validated pipeline for registration and segmentation of high-resolution mouse brain data
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article Anatomical segmentation of high-resolution 3D microscopy datasets is necessary to map large samples at cellular resolution. Here the authors present a pipeline for automated mouse atlas propagation (aMAP) to segment fluorescence images of the adult mouse brain and validate it against human segmentations. Nature Communications doi: 10.1038/ncomms11879 Authors: Christian J. Niedworok, Alexander P. Y. […]
Microcanonical and resource-theoretic derivations of the thermal state of a quantum system with noncommuting charges
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article A central concept in thermodynamics is the thermal state, which is the one towards which the system relaxes. Here, the authors derive the same state, through three different approaches, in the case of a quantum system whose conserved quantities correspond to operators that do not commute with one another. Nature Communications doi: 10.1038/ncomms12051 Authors: […]
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41 in renal cells. Nature Communications doi: 10.1038/ncomms12098 Authors: Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. […]
Extra-coding RNAs regulate neuronal DNA methylation dynamics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to control gene expression in locus-specific manner in neurons. Nature Communications doi: 10.1038/ncomms12091 Authors: Katherine E. Savell, Nancy V. […]
Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article Chromosomal aberrations can be detected by global gene expression analysis. Here, the authors report eSNP-Karyotyping, a new method that can detect chromosomal aberrations by measuring the ratio of expression between the two alleles without comparison to a matched diploid sample. Nature Communications doi: 10.1038/ncomms12144 Authors: Uri Weissbein, Maya Schachter, Dieter Egli, Nissim Benvenisty from […]
The mechanical response of talin
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions. Nature Communications doi: 10.1038/ncomms11966 Authors: Mingxi Yao, Benjamin T. […]
Van der Waals pressure and its effect on trapped interlayer molecules
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Article Molecules trapped between the layers of two-dimensional materials are thought to experience high pressure. Here, the authors report measurements of this interfacial pressure by capturing pressure-sensitive molecules and studying their structural changes, and show that it can also induce chemical reaction. Nature Communications doi: 10.1038/ncomms12168 Authors: K. S. Vasu, E. Prestat, J. Abraham, J. […]
Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Objective The objective of this article is to analyze the features of headache attributed to hypothyroidism (HAH), evaluate the differences between groups with and without HAH, between «overt» and «subclinical» hypothyroidism groups, and evaluate outcomes after levothyroxine treatment. Methods Patients with hypothyroidism were selected in a cross-sectional study, followed prospectively for 12 months, and classified […]
Ειδοποίηση Μελετητή - [ Thyroid ]
*Ειδοποίηση Μελετητή:[ Thyroid ]* A cutaneous false positive in radioiodine scintigraphy for metastatic *thyroid *cancer EA McAninch, RM Calderon, A Kargi - US Endocrinology, 2016 Abstract Contamination of external sites with secretions or excretory products can mimic metastases and yield false positives in radioiodine whole-body scintigraphy for *thyroid * cancer. We present a case of a 26-year-old woman with differentiated papillary *thyroid ** ...* Preservation of renal function by *thyroid *hormone replacement in elderly persons with subclinical hypothyroidism Y Lu, H Guo, D Li... περισσότερα »
Ειδοποίηση Μελετητή - [ Head and Neck's Diseases ]
*Ειδοποίηση Μελετητή:[ Head and Neck's Diseases ]* Inherited Metabolic *Disease *in Adults: A Clinical Guide R Lachmann - 2016 *...* Syndromes of the *head* and *neck*, fourth edition MM Cohen, Jr., G. Neri, and R. Weksberg: Overgrowth syndromes RA King, JI Rotter, and AG Motulsky: & e genetic basis of common *diseases*, second edition GP Bates, PS Harper, and L. Jones: Huntington's *disease*, third edition *...* [HTML] Self-image of the patients with *head *and *neck *cancer: A mixed method research SG Nayak, MS Pai, LS George - Indian Journal of Palliative Care, 2016 *...* I feel ... περισσότερα »
Ειδοποίηση Μελετητή - [ NasoPharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ NasoPharynx's Diseases ]* Sub-section editor: Maurice Hawthorne M Hawthorne - Oxford Textbook of Fundamentals of Surgery, 2016 *...* Although smoking and alcohol are the main risk factors for OPSCC, this *disease* is appearing in younger non-smoking indi- viduals, related to HPV acquired through oral sex or perinatal *...* Occasionally, juvenile angiofribroma can present as a vascular mass in the *nasopharynx*. *...* Chronic plasma cell balanitis of Zoon VN SEHGAL, VL REGE, GB MALIK *...* Genital sores are common in venereal *disease* clinics and most of them ... περισσότερα »
Ειδοποίηση Μελετητή - [ Salivary Glands ]
*Ειδοποίηση Μελετητή:[ Salivary Glands ]* Muscarinic cholinergic receptors (MR3) in saliva of patients with oral lichen planus F Agha-Hosseini, I Mirzaii-Dizgah, N Mohammadpour - Archives of Dermatological …, 2016 *...* This theory has been confirmed by a study on the *parotid* gland of a rat model and also by functional studies on this gland. M3 muscarinic receptors are probably the main mediators of cholinergic response in the *salivary* *glands* [24]. *...* Identification of differentially expressed genes in *salivary *adenoid cystic carcinoma cells associated with metastasis W ... περισσότερα »
Ειδοποίηση Μελετητή - [ Hearing ]
*Ειδοποίηση Μελετητή:[ Hearing ]* The Transition From Early Intervention to School for Deaf and Hard-of-*Hearing *Children BT Poon, JR Jamieson, A Zaidman-Zait, D Curle… - Diversity in Deaf Education, 2016 The transition to school is, arguably, the first major transition in the lives of children. Most children first enter school at kindergarten, which is a markedly different environment from home or early-childhood settings such as preschool or daycare. In addition to the move to * ...* Critical Factors Toward the Inclusion of Deaf and Hard-of-*Hearing *Students in Higher Educati... περισσότερα »
Ειδοποίηση Μελετητή - [ Pharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ Pharynx's Diseases ]* Clinical update: Common cardiovascular conditions in children SP Paul, PR Paul, TC Mcallister - Community Practitioner, 2016 *...* Penicillin is commenced to eradicate group A streptococcus from the *pharynx* after obtaining a throat swab. *...* See: http://www.chop.edu/conditions-*diseases* /symptoms-might-indicate-heart- problem#.VzuQxED2bIU [Accessed 01/06 *...* Archives of *Disease* in Childhood, 98(9): 714-7. *...* Ear pain and hearing loss M Hawthorne - Oxford Textbook of Fundamentals of Surgery, 2016 *...* Common 'inno- cent'causes i... περισσότερα »
Ειδοποίηση Μελετητή - [ Melanoma ]
*Ειδοποίηση Μελετητή:[ Melanoma ]* Sickle Cells Abolish *Melanoma *Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus in Vivo CW Sun, C Willmon, LC Wu, P Knopick, J Thoerner… - Frontiers in Oncology, 2016 Insights from the study of cancer resistance in animals have led to the discovery of novel anti- cancer pathways and opened new venues for cancer prevention and treatment. Sickle cells (SSRBCs) from subjects with homozygous sickle cell anemia (SCA) have been shown to * ...* [HTML] Systematic review of the use of granulocyte–macrophage... περισσότερα »
Ειδοποίηση Μελετητή - [ Foreign Body Aspiration ]
*Ειδοποίηση Μελετητή:[ Foreign Body Aspiration ]* [HTML] Role of virtual and flexible bronchoscopy in the management of a case of unnoticed *foreign body aspiration *presented as nonresolving pneumonia in an adult female RM Kshatriya, NV Khara, RP Paliwal, SN Patel - Lung India, 2016 Abstract It is not so common to aspirate *foreign body *in normal adults without any predisposing factors as compared to children and those with the altered neurological state. Endobronchial *foreign *bodies are one of the causes of obstructive pneumonia and difficult * ...* [HTML] Incidental intraope... περισσότερα »
Ειδοποίηση Μελετητή - [ Larynx's Diseases ]
*Ειδοποίηση Μελετητή:[ Larynx's Diseases ]* [HTML] Effect of gastroesophageal reflux *disease *on spirometry, lung diffusion, and impulse oscillometry ER Ali, HM Abdelhamid, H Shalaby - Egyptian Journal of Bronchology, 2016 *...* Nonetheless, the airways and alveoli would seem to be poorly designed to resist the noxious refluxate once it has traversed past the *larynx*. *...* Patients who smoked and those with known respiratory *diseases*, ischemic heart *disease*, heart failure, liver disorders, or *...* Sub-section editor: Maurice Hawthorne M Hawthorne - Oxford Textbook of Fundame... περισσότερα »
Ειδοποίηση Μελετητή - [ Ear's Diseases ]
*Ειδοποίηση Μελετητή:[ Ear's Diseases ]* *Ear *pain and hearing loss M Hawthorne - Oxford Textbook of Fundamentals of Surgery, 2016 *...* Common 'inno- cent'causes include post-tonsillectomy pain, dental extraction or dental *disease* origin, arthritis in the upper cervical spine, temporo- mandibular joint syndrome, and benign ulcers of the *...* As humans have two *ears* it is possible for the non-test *ear* to be the *...* [PDF] Transcutaneous Vagus Nerve Stimulation for the Treatment of Insomnia Disorder: A Study Protocol for a Double Blinded Randomized Clinical Trial L Shao-Yuan... περισσότερα »
Ειδοποίηση Μελετητή - [ Cochlea's Diseases ]
*Ειδοποίηση Μελετητή:[ Cochlea's Diseases ]* Ear pain and hearing loss M Hawthorne - Oxford Textbook of Fundamentals of Surgery, 2016 *...* Common 'inno- cent'causes include post-tonsillectomy pain, dental extraction or dental *disease* origin, arthritis in the upper cervical spine, temporo- mandibular joint *...* It is progressive, usually affecting both ears, and eventually will affect the *cochlea* causing a sensory deafness. *...* Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells RI ReitaroTokumasuͷ, A Matsubara, N Mori, ... περισσότερα »
Ειδοποίηση Μελετητή - [ HypoPharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ HypoPharynx's Diseases ]* Ear pain and hearing loss M Hawthorne - Oxford Textbook of Fundamentals of Surgery, 2016 *...* Common 'inno- cent'causes include post-tonsillectomy pain, dental extraction or dental *disease* origin, arthritis in the upper cervical spine, temporo- mandibular joint *...* Common examples include carcinoma of the tongue, tonsil, oropharynx, *hypopharynx*, larynx, and floor of mouth *...* [PDF] Simulation Research on a New Spot-First-Aid of Foreign Body Asphyxia in the *Hypopharynx* L Chen - 2016 *...* The author's research group proposed... περισσότερα »
Ειδοποίηση Μελετητή - [ Vertigo ]
*Ειδοποίηση Μελετητή:[ Vertigo ]* 7 Overlooking affect? G Hoskins - Heritage, Affect and Emotion: Politics, practices and …, 2016 [PDF] Laboratorijas metožu aprobācija lauka pupu izturības pret lapu patogēniem Botrytis fabae, Ascochyta fabae un Stemphylium sarcinaeforme paātrinātai noteikšanai EA Brauna - 2016 *...* S. sarcinaeforme B. fabae A.fabae Izturīgas Stipri līdz vidēji izturīgas Boba, Reda Olga, Izabella, Boba, Boxer, *Vertigo* Vidēji izturīgas Granit, Izabella, Olga Julia, Alba *Vertigo*, Boba, Olga, Reda, Laura Vidēji līdz vāji izturīgas Ada, Alexia, *Vertigo* Ada, Alexia ... περισσότερα »
Ειδοποίηση Μελετητή - [ Throat's Diseases ]
*Ειδοποίηση Μελετητή:[ Throat's Diseases ]* Hand, foot, and mouth *disease*: A case series from rural set up of Gujarat R Singh, N Diwan, P Nair - 2016 *...* Hand foot and mouth *disease* (HFMD) is common viral illness among children characterized by prodromal fever followed by sore *throat*, rash over hands and feet, and ulcers in mouth. Though rare, patients can develop complications. *...* Tick-Borne Illnesses FH Kohanna - Professional Safety, 2016 *...* Ticks & Infectious *Disease*. *...* *Diseases* can ticks can transmit to humans include: *...* The most common symptoms are head... περισσότερα »
Ειδοποίηση Μελετητή - [ Nose's Diseases ]
*Ειδοποίηση Μελετητή:[ Nose's Diseases ]* Sociocultural Contexts and Stressors WS Williams, A Ginsberg, B Mandryk - The Oxford Handbook of Treatment Processes …, 2016 *...* binge eating (Mwendwa et al., 2011), and use of drugs (Stevens-Watkins, Perry, Harp, & Oser, 2012) and alcohol are maladaptive stress coping strategies directly linked to exposure to racism and are also associated with heightened instances of preventable *diseases*, such as *...* The Pew Commission Report BE Rollin - The Routledge Handbook of Food Ethics, 2016 [PDF] Behavioral Finance. S Page, J Gordon - 2016 *.... περισσότερα »
Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination
Publication date: Available online 6 July 2016 *Source:*Clinical Immunology Author(s): Kaushiki Biswas, Dhriti Chatterjee, Sankar Addya, Reas S. Khan, Lawrence C. Kenyon, Alexander Choe, Randall J. Cohrs, Kenneth S. Shindler, Jayasri Das Sarmaa The presence of immunoglobulin oligoclonal bands in the cerebrospinal fluid of Multiple Sclerosis (MS) patients supports the hypothesis of an infectious etiology, although the antigenic targets remain elusive. Neurotropic mouse hepatitis virus (MHV) infection in mice provides a useful tool for studying mechanisms of demyelination in a virus-i... περισσότερα »
Frequent detection of human polyomavirus 6 in keratoacanthomas
AbstractBackground The recent discovery of the Merkel cell polyomavirus and its consistent association with Merkel cell carcinoma has drawn attention to the numerous recently discovered polyomaviruses and their possible involvement in the etiopathogenesis of non-melanoma skin cancer (NMSC). Data on the recently discovered human polyomavirus 6 (HPyV6) and its role in NMSC are sparse and in part controversial. Methods In the present study we tested a large number (*n* = 299) of NMSC specimens for the presence of human polyomavirus 6 (HPyV6) by DNA PCR and HPyV6 fluorescence in situ h... περισσότερα »
Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma: The estimated body mass index (BMI) in the United States has increased drastically over the past several decades with estimates from 2008 suggesting that >60% of adult females and 70% of adult males are overweight (BMI>25kg/m2) [1]. In the […]
Human Speech: A Restricted Use of the Mammalian Larynx
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Human Speech: A Restricted Use of the Mammalian Larynx: Speech has been hailed as unique to human evolution. Although the inventory of distinct sounds producible with vocal tract articulators is a great advantage in human oral communication, it is argued here that the larynx as a sound source in speech is limited in its range […]
The Psychometric Properties of the Voice Handicap Index in People With Parkinson’s Disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
The Psychometric Properties of the Voice Handicap Index in People With Parkinson’s Disease: Psychosocial impact of dysphonia in people with Parkinson disease (PD) has been described with the Voice Handicap Index (VHI); however, its psychometric properties when applied in this population are not described. Summary Background Psychosocial impact of dysphonia in people with Parkinson disease […]
Fundamental Frequency Variation in Crying of Mandarin and German Neonates
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Fundamental Frequency Variation in Crying of Mandarin and German Neonates: This study examined whether prenatal exposure to either a tonal or a nontonal maternal language affects fundamental frequency (fo) properties in neonatal crying. Summary Objectives This study examined whether prenatal exposure to either a tonal or a nontonal maternal language affects fundamental frequency (fo) properties […]
Antibacterial and antifouling activities of chitosan/TiO 2 /Ag NPs nanocomposite films against packaged drinking water bacterial isolates
Abstract TiO2 and Ag NPs are widely used as antibacterial agents against many bacterial pathogens. Chitosan (polymer) itself acts as a strong antibacterial agent. Hence, chitosan/TiO2/Ag NPs incorporated nanocomposite film was prepared against packed drinking water bacterial strains. A concentration-dependent increase in the reduction of cell viability was observed in all the isolates under UV-C and dark exposure conditions. The bacteria consortium showed greater resistance against antibacterial effects of chitosan/TiO2/Ag nanocomposite as compared to single isolates. Glycocalyx t... περισσότερα »
Treatment of a simulated textile wastewater containing the Reactive Orange 16 azo dye by a combination of ozonation and moving-bed biofilm reactor: evaluating the performance, toxicity, and oxidation by-products
Abstract In this study, an aqueous solution containing the azo dye Reactive Orange 16 (RO16) was subjected to two sequential treatment processes, namely: ozonation and biological treatment in a moving-bed biofilm reactor (MBBR). The most appropriate ozonation pretreatment conditions for the biological process and the toxicity of the by-products resulting from RO16 ozone oxidation were evaluated. The results showed that more than 97 % of color removal from the dye solutions with RO16 concentrations ranging from 25 to 100 mg/L was observed in 5 min of ozone exposure. However, the max... περισσότερα »
Dopamine in plasma – a biomarker for myofascial TMD pain?
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD a... http://ift.tt/29CT2gd
Dopamine in plasma – a biomarker for myofascial TMD pain?
Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD a… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29CT2gd via IFTTT
Topography of the coracobrachialis muscle and the musculocutaneous nerve by muscular variation
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29mBOlw via IFTTT
Topography of the coracobrachialis muscle and the musculocutaneous nerve by muscular variation
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29mBOlw via IFTTT
High potential for weathering and climate effects of non-vascular vegetation in the Late Ordovician
Article Early non-vascular vegetation may have caused an interval of glaciations in the Late Ordovician by enhancing global chemical weathering. Here, by simulating the organisms with a spatially explicit, process-based model, the authors propose that Ordovician vegetation had a high potential for chemical weathering. Nature Communications doi: 10.1038/ncomms12113 Authors: P. Porada, T. M. Lenton, A.… Continue reading High potential for weathering and climate effects of non-vascular vegetation in the Late Ordovician
Thermodynamics of quantum systems with multiple conserved quantities
Article The second law of thermodynamics constrains how much of a conserved quantity, such as energy, can be extracted from a system in the form of work. Here, the authors generalize this law to quantum systems whose conserved quantities need not commute, showing that it is their combination to be constrained. Nature Communications doi: 10.1038/ncomms12049… Continue reading Thermodynamics of quantum systems with multiple conserved quantities
aMAP is a validated pipeline for registration and segmentation of high-resolution mouse brain data
Article Anatomical segmentation of high-resolution 3D microscopy datasets is necessary to map large samples at cellular resolution. Here the authors present a pipeline for automated mouse atlas propagation (aMAP) to segment fluorescence images of the adult mouse brain and validate it against human segmentations. Nature Communications doi: 10.1038/ncomms11879 Authors: Christian J. Niedworok, Alexander P. Y.… Continue reading aMAP is a validated pipeline for registration and segmentation of high-resolution mouse brain data
Microcanonical and resource-theoretic derivations of the thermal state of a quantum system with noncommuting charges
Article A central concept in thermodynamics is the thermal state, which is the one towards which the system relaxes. Here, the authors derive the same state, through three different approaches, in the case of a quantum system whose conserved quantities correspond to operators that do not commute with one another. Nature Communications doi: 10.1038/ncomms12051 Authors:… Continue reading Microcanonical and resource-theoretic derivations of the thermal state of a quantum system with noncommuting charges
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
Article A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41 in renal cells. Nature Communications doi: 10.1038/ncomms12098 Authors: Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A.… Continue reading Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
Extra-coding RNAs regulate neuronal DNA methylation dynamics
Article DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to control gene expression in locus-specific manner in neurons. Nature Communications doi: 10.1038/ncomms12091 Authors: Katherine E. Savell, Nancy V.… Continue reading Extra-coding RNAs regulate neuronal DNA methylation dynamics
Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq
Article Chromosomal aberrations can be detected by global gene expression analysis. Here, the authors report eSNP-Karyotyping, a new method that can detect chromosomal aberrations by measuring the ratio of expression between the two alleles without comparison to a matched diploid sample. Nature Communications doi: 10.1038/ncomms12144 Authors: Uri Weissbein, Maya Schachter, Dieter Egli, Nissim Benvenisty from… Continue reading Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq
Dopamine in plasma – a biomarker for myofascial TMD pain?
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 31 δευτερόλεπτα
Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD a… http://ift.tt/29CT2gd
Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 31 δευτερόλεπτα
Objective The objective of this article is to analyze the features of headache attributed to hypothyroidism (HAH), evaluate the differences between groups with and without HAH, between “overt” and “subclinical” hypothyroidism groups, and evaluate outcomes after levothyroxine treatment. Methods Patients with hypothyroidism were selected in a cross-sectional study, followed prospectively for 12 months, and classified as subclinical or overt hypothyroidism. The patients were divided into two groups: with and without HAH. Results HAH was reported by 73/213 (34%) patients, involving the... περισσότερα »
Medical dispatchers recognise substantial amount of acute stroke during emergency calls
Immediate recognition of stroke symptoms is crucial to ensure timely access to revascularisation therapy. Medical dispatchers ensure fast admission to stroke facilities by prioritising the appropriate medical ... from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29r7zfi
Topography of the coracobrachialis muscle and the musculocutaneous nerve by muscular variation
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/29mBOlw via IFTTT
Extramammary paget's disease mimicking localized malignancy on cervical cytology
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
A case of Extramammary Paget's Disease (EMPD) involving the cervix mimicking cervical carcinoma on routine cervical cytology in a 66-year-old woman with a history of recurrent multifocal EMPD involving the vulva, perineum, perianal area, and rectum is reported. The patient had undergone multiple excisions and reconstructions of EMPD, however, had a benign cervical smear history and reported no vaginal bleeding. The conventional papanicolaou smear was reported as concerning for carcinoma with abundant, well preserved material illustrating highly atypical cells with anisonucleosis ... περισσότερα »
Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Hypocalcemia is a metabolic disorder that affects dairy cows during the transition from pregnancy to lactation. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 days prepartum with either saline or 1.0mg/kg bodyweight of the immediate precursor to serotonin synthesis, 5hydroxy-l-tryptophan (5-HTP). On infusion days, blood was collected […]
Obesity, hypertension and aldosterone: is leptin the link?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Obesity is a serious health hazard with rapidly increasing prevalence in the United States. In 2014, the World Health Organization estimated that nearly 2 billion people worldwide were overweight with an estimated 600 million of these obese. Obesity is associated with many chronic diseases, including cardiovascular disease and hypertension. Data from the Framingham Heart study […]
Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
The glucocorticoids bind and activate both the glucocorticoid receptor (GR) as well as the mineralocorticoid receptor in adipocytes. Despite several studies to determine the function of these two receptors in mediating glucocorticoids effects, their relative contribution in adipose tissue expansion and obesity is unclear. To investigate the effect of GR in adipose tissue function, we […]
Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific deletion of Mrap2 in mice results in severe obesity. Loss-of-function MRAP2 mutations have also been associated with obesity in humans. Although MRAP2 has been shown to interact with MC4R, a G protein-coupled receptor with an […]
Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine
Objective The objective of this article is to analyze the features of headache attributed to hypothyroidism (HAH), evaluate the differences between groups with and without HAH, between «overt» and «subclinical» hypothyroidism groups, and evaluate outcomes after levothyroxine treatment. Methods Patients with hypothyroidism were selected in a cross-sectional study, followed prospectively for 12 months, and classified… Continue reading Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine
Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study
Purpose. So-called spontaneous remissions in cancer often seem to occur after febrile events. Mistletoe preparations (MPs) are used off-label intravenously to induce fever within concepts of integrative oncology. We wanted to investigate the frequency of febrile reactions and safety related to intravenously applied MPs (IAMPs). Methods. This was a retrospective analysis of data from consecutive… Continue reading Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study
Progestin increases the expression of gonadotropins in pituitaries of male zebrafish
Our previous study showed that the in vivo positive effects of 17α,20β-dihydroxy-4-pregnen-3-one (DHP), the major progestin in zebrafish, on early spermatogenesis was much stronger than the ex vivo ones, which may suggest an effect of DHP on the expression of gonadotropins. In our present study, we first observed that fshb and lhb mRNA levels in… Continue reading Progestin increases the expression of gonadotropins in pituitaries of male zebrafish
Precise expression of Fis1 is important for glucose responsiveness of beta cells
Mitochondrial network functionality is vital for glucose-stimulated insulin secretion in pancreatic beta cells. Altered mitochondrial dynamics in pancreatic beta cells are thought to trigger the development of type 2 diabetes mellitus. Fission protein 1 (Fis1) might be a key player in this process. Thus, the aim of this study was to investigate mitochondrial morphology in… Continue reading Precise expression of Fis1 is important for glucose responsiveness of beta cells
Improvements in IVF in women of advanced age
Women above age 40 years in the US now represent the most rapidly growing age group having children. Patients undergoing in vitro fertilization (IVF) are rapidly aging in parallel. Especially where egg donations are legal, donation cycles, therefore, multiply more rapidly than autologous IVF cycles. The donor oocytes, however, are hardly ever a preferred patient… Continue reading Improvements in IVF in women of advanced age
The role of GPR1 signaling in mice corpus luteum
Chemerin, a chemokine, plays important roles in immune responses, inflammation, adipogenesis, and carbohydrate metabolism. Our recent research has shown that chemerin has an inhibitory effect on hormone secretion from the testis and ovary. However, whether G protein-coupled receptor 1 (GPR1), the active receptor for chemerin, regulates steroidogenesis and luteolysis in the corpus luteum is still… Continue reading The role of GPR1 signaling in mice corpus luteum
Endocrine regulation of circadian physiology
Endogenous circadian clocks regulate 24-h rhythms of behavior and physiology to align with external time. The endocrine system serves as a major clock output to regulate various biological processes. Recent findings suggest that some of the rhythmic hormones can also provide feedback to the circadian system at various levels, thus contributing to maintaining the robustness… Continue reading Endocrine regulation of circadian physiology
Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow
Hypocalcemia is a metabolic disorder that affects dairy cows during the transition from pregnancy to lactation. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 days prepartum with either saline or 1.0mg/kg bodyweight of the immediate precursor to serotonin synthesis, 5hydroxy-l-tryptophan (5-HTP). On infusion days, blood was collected… Continue reading Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow
Obesity, hypertension and aldosterone: is leptin the link?
Obesity is a serious health hazard with rapidly increasing prevalence in the United States. In 2014, the World Health Organization estimated that nearly 2 billion people worldwide were overweight with an estimated 600 million of these obese. Obesity is associated with many chronic diseases, including cardiovascular disease and hypertension. Data from the Framingham Heart study… Continue reading Obesity, hypertension and aldosterone: is leptin the link?
Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth
The glucocorticoids bind and activate both the glucocorticoid receptor (GR) as well as the mineralocorticoid receptor in adipocytes. Despite several studies to determine the function of these two receptors in mediating glucocorticoids effects, their relative contribution in adipose tissue expansion and obesity is unclear. To investigate the effect of GR in adipose tissue function, we… Continue reading Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth
In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
In situ estrogen biosynthesis is considered to play pivotal roles in the development and progression of human endometrial carcinoma. However, the biological roles of androgen have remained virtually unknown. Various epidemiological studies have revealed that elevated serum androgen levels are generally associated with an increased risk of developing endometrial carcinoma; however, studies directly examining androgens […]
A randomized controlled study comparing a vessel sealing system with the conventional technique in axillary lymph node dissection for primary breast cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
This study aimed to compare the efficacy and safety of the newest bipolar vessel sealing system (BVSS; LigaSure™ Small Jaw) to that of conventional technique in axillary dissection. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29sDP2M via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells enhances the recruitment of CD11b+ myeloid cells to the lungs and facilitates B16-F10 melanoma colonization
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 15 July 2016 Source:Experimental Cell Research, Volume 345, Issue 2 Author(s): Lucas E.B. Souza, Danilo C. Almeida, Juliana N.U. Yaochite, Dimas T. Covas, Aparecida M. Fontes The discovery that the regenerative properties of bone marrow multipotent mesenchymal stromal cells (BM-MSCs) could collaterally favor neoplastic progression has led to a great interest in the […]
SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 15 July 2016 Source:Experimental Cell Research, Volume 345, Issue 2 Author(s): Yu-Tzu Chang, Chung-Li Shu, Jing-Yang Lai, Ching-Yu Lin, Chih-Pin Chuu, Kazuhiro Morishita, Tomonaga Ichikawa, Rolf Jessberger, Yasuhisa Fukui Mouse embryo fibroblasts (MEFs) grow slowly after cultivation from animals, however, after an extended period of cultivation, their growth accelerates. We found that SWAP-70 […]
IFC/ Editorial Board
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 15 July 2016 Source:Experimental Cell Research, Volume 345, Issue 2 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29CMe1R via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine
Objective The objective of this article is to analyze the features of headache attributed to hypothyroidism (HAH), evaluate the differences between groups with and without HAH, between "overt" and "subclinical" hypothyroidism groups, and evaluate outcomes after levothyroxine treatment. Methods Patients with hypothyroidism were selected in a cross-sectional study, followed prospectively for 12 months, and classified as subclinical or overt hypothyroidism. The patients were divided into two groups: with and without HAH. Results HAH was reported by 73/213 (34%) patients, involvin... περισσότερα »
Bone regenerative effect of recombinant human bone morphogenetic protein-2 after cyst enucleation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background The aim of this study is to quantitatively evaluate the effect of rhBMP-2 for repair of bone defects after cyst enucleation using the osteogenesis index (OI). Methods Under general anesthesia, 10 patients (12 lesions) underwent oral or maxillofacial surgery for cyst enucleation. Postoperatively, 12 lesions were divided into two groups: group A (six […]
Complete Tissue Submission to Increase Lymph Node Detection in Pelvic Lymph Node Packets Submitted for Patients Undergoing Radical Prostatectomy and Radical Cystectomy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background. Pelvic lymphadenectomy has prognostic and therapeutic implications in both bladder and prostate cancer. Pelvic lymphadenectomy specimens are fatty and identification of lymph nodes (LNs) can be difficult during the grossing process. We investigated the benefit of a new grossing method requiring entire LN packet submission. Materials/Methods. We introduced a new grossing protocol requiring total […]
Intraosseous Hibernoma in the Sacrum of an Adult
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological […]
Autoantibodies in Autoimmune Liver Diseases–Methods of Detection and Interpretation: An Update for the Reporting Pathologist
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic. […]
Spatial and temporal patterns in the Pelagibacteraceae across an estuarine gradient
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Marine bacterial communities show strong spatial and seasonal patterns, often characterized by changes at high taxonomic levels. The Pelagibacteraceae are common members of bacterial communities, with well documented biogeography at the subclade level. To identify patterns within the subclades, the abundance and diversity of Pelagibacteraceae was analyzed over a two-year period at four stations across […]
Bacterial and fungal symbionts of parasitic Dendroctonus bark beetles
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Bark beetles (Curculionidae: Scolytinae) are one of the most species-rich herbivorous insect groups with many shifts in ecology and host-plant use, which may be mediated by their bacterial and fungal symbionts. While symbionts are well studied in economically important, tree-killing species, little is known about parasitic species whose broods develop in living trees. Here, using […]
The role of plant-microbiome interactions in weed establishment and control
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The soil microbiome plays an important role for the establishment of weeds and invasive plants. They associate with microorganisms supporting their growth and health. Weed management strategies, like tillage and herbicide treatments, to control weeds generally alter soil structure going alongside with changes also the microbial community. Once a weed population establishes in the field, […]
Active microorganisms in forest soils differ from the total community yet are shaped by the same environmental factors: the influence of pH and soil moisture
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Predicting the impact of environmental change on soil microbial functions requires an understanding of how environmental factors shape microbial composition. Here, we investigated the influence of environmental factors on bacterial and fungal communities across an expanse of northern hardwood forest in Michigan, USA, which spans a 500-km regional climate gradient. We quantified soil microbial community […]
Hydrocarbon biodegradation by Arctic sea-ice and sub-ice microbial communities during microcosm experiments, Northwest Passage (Nunavut, Canada)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The increasing accessibility to navigation and offshore oil exploration brings risks of hydrocarbon releases in Arctic waters. Bioremediation of hydrocarbons is a promising mitigation strategy but challenges remain, particularly due to low microbial metabolic rates in cold, ice-covered seas. Hydrocarbon degradation potential of ice-associated microbes collected from the Northwest Passage was investigated. Microcosm incubations were […]
Capsule of Streptococcus equi subsp. zooepidemicus hampers the adherence and invasion of epithelial and endothelial cells and is attenuated during internalization
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Direct interaction between pathogens and host cells often is a prerequisite for colonization, infection and dissemination. Regulated production of capsular polysaccharide (CPS), which is made of hyaluronic acid, is essential for the pathogenicity of Streptococcus equi subsp. zooepidemicus. Here, we constructed a CPS-deleted mutant and analyzed it along with the parental wild-type strain in attachment […]
Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy , Vol. 0, No. 0. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29uOVmP
Evaluation of rhamnolipid addition on the natural attenuation of estuarine sediments contaminated with diesel oil
Abstract The aim of the present study was to assess the bioremediation of estuarine sediments contaminated with diesel oil. The following two experiments were performed: natural attenuation (NA) and stimulated natural attenuation (SNA), using rhamnolipid as biosurfactant. Sediment samples were accommodated into glass columns and then contaminated with diesel oil on the top. The column profiles were separated into surface, middle, and bottom for the analyses. The 16 polycyclic aromatic hydrocarbons (PAHs) prioritized by US Environmental Protection Agency (EPA) were monitored for 34... περισσότερα »
Photochemical behavior of carbon nanotubes in natural waters: reactive oxygen species production and effects on •OH generation by Suwannee River fulvic acid, nitrate, and Fe (III)
Abstract The photochemical activities of three kinds of carbon nanotubes (CNTs) were investigated in the present study. Efficient procedures of dispersing the three kinds of carbon nanotubes in water were established, and the quantitative analysis methods were also developed by TOC-absorbance method. High pH value or low ionic strength of the colloidal solutions facilitated the dispersion of CNTs. The suspensions of three kinds of CNTs could generate singlet oxygen (1O2) and hydroxyl radical (•OH) under irradiation of simulated sunlight, while superoxide radical (O2•−) was not dete... περισσότερα »
Complete Tissue Submission to Increase Lymph Node Detection in Pelvic Lymph Node Packets Submitted for Patients Undergoing Radical Prostatectomy and Radical Cystectomy
*Background.* Pelvic lymphadenectomy has prognostic and therapeutic implications in both bladder and prostate cancer. Pelvic lymphadenectomy specimens are fatty and identification of lymph nodes (LNs) can be difficult during the grossing process. We investigated the benefit of a new grossing method requiring entire LN packet submission. *Materials/Methods.* We introduced a new grossing protocol requiring total submission of LN packets for patients undergoing radical prostatectomy (RP) or radical cystectomy (RC). A retrospective review was performed to evaluate clinical and patholo... περισσότερα »
Intraosseous Hibernoma in the Sacrum of an Adult
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological and immunohistochemical profile consistent with brown fat cells. The lesion was diagnosed as an intraosseous hibernoma. This is the 16th report in the English literature of a hibernoma occurring outside of a soft ti... περισσότερα »
Autoantibodies in Autoimmune Liver Diseases--Methods of Detection and Interpretation: An Update for the Reporting Pathologist
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic. Moreover, these autoantibodies are detected in many other pathological and nonpathological conditions. So the significance of seropositivity for these autoantibodies should be known by both the pathologists as well as the clinicians. I... περισσότερα »
Combined infection training--a pioneering collaborative approach to educating infection specialists
This commentary discusses the recent pioneering overhaul of training for UK doctors wishing to pursue a career in the infection specialities. Changes include the introduction of new curricula that embrace increased collaboration between the laboratory-based and clinical specialties and a broad-based infection training period, named 'Combined Infection Training', which has never been seen before. Here, we discuss the benefits and challenges associated with the collaborative approach to training with particular reference to points that educators responsible for training programme de... περισσότερα »
Burkholderia pseudomallei rpoS mediates iNOS suppression in human hepatocyte (HC04) cells
*Burkholderia pseudomallei* is an intracellular Gram-negative bacterial pathogen and the causative agent of melioidosis, a widespread disease in Southeast Asia. Reactive nitrogen, in an intermediate form of nitric oxide (NO), is one of the first lines of defense used by host cells to eliminate intracellular pathogens, through the stimulation of inducible nitric oxide synthase (iNOS). Studies in phagocytotic cells have shown that the iNOS response is muted in *B. pseudomallei* infection, and implicated the *rpoS* sigma factor as a key regulatory factor mediating suppression. The liv... περισσότερα »
Capsule of Streptococcus equi subsp. zooepidemicus hampers the adherence and invasion of epithelial and endothelial cells and is attenuated during internalization
Direct interaction between pathogens and host cells often is a prerequisite for colonization, infection and dissemination. Regulated production of capsular polysaccharide (CPS), which is made of hyaluronic acid, is essential for the pathogenicity of *Streptococcus equi* subsp. *zooepidemicus*. Here, we constructed a CPS-deleted mutant and analyzed it along with the parental wild-type strain in attachment and invasion of mammalian epithelial and endothelial cell lines. The CPS-deleted mutant exhibited significant increase in adherence and invasion by several orders of magnitude com... περισσότερα »
Screening of KHP30-like prophages among Japanese Helicobacter pylori strains, and genetic analysis of a defective KHP30-like prophage sequence integrated in the genome of the H. pylori strain NY40
We have recently reported the active *Helicobacter pylori* bacteriophages (phages) KHP30 and KHP40, the genomic DNAs of which exist as episomes in host bacterial strains isolated in Japan (*i.e.*, pseudolysogeny). In this study, we examined the possibility of the lysogeny of active KHP30-like phages in Japanese *H. pylori* strains, because their genomes contain a putative integrase gene. Only the NY40 strain yielded partial detection of a KHP30-like prophage sequence in PCR among 174 Japanese *H. pylori* isolates, except for strains producing the above active phages. Next, accordi... περισσότερα »
Reply to Bernard et al
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29mpYX2 via IFTTT
Θεσπίστηκε ημέρα κακώσεων νωτιαίου μυελού η 5η Σεπτέμβρη
http://ift.tt/29AIq43 from Neurology via xlomafota13 on Inoreader http://ift.tt/29CPWbN via IFTTT
24ου Πανελληνίου Συνεδρίου της Ελληνικής Εταιρείας Μελέτης Μεταβολισμού των Οστών, 4 έως 6 Νοεμβρίου 2016
Αγαπητοί κύριοι Αγαπητές κυρίες Με την επιστολή μας αυτή θα θέλαμε να σας γνωστοποιήσουμε τη διοργάνωση του *24ου Πανελληνίου Συνεδρίου της Ελληνικής Εταιρείας Μελέτης Μεταβολισμού των Οστών, *που θα πραγματοποιηθεί από *4 έως 6 Νοεμβρίου 2016*, στο ξενοδοχείο Grand Serai, στα Ιωάννινα. Το συνέδριο αποβλέπει στην υψηλού επιπέδου επιστημονική ενημέρωση και ανταλλαγή απόψεων μεταξύ ιατρών διαφόρων ειδικοτήτων που ασχολούνται με τα μεταβολικά νοσήματα των οστών. Φέτος το συνέδριο φιλοξενεί διακεκριμένους επιστήμονες, μέλη δύο συγγενών επιστημονικών εταιρειών, του Ελληνικού Ιδρύματος... περισσότερα »
Αποκατάσταση μυών, τενόντων, συνδέσμων
Δημοσίευση από το περιοδικό Σκελετική Υγεία DIONYSSIOTIS_COVER from Neurology via xlomafota13 on Inoreader http://ift.tt/29AI6SN via IFTTT
Ινομυαλγία. Ο συνδυασμός φαρμάκων ίσως φέρει καλύτερο θεραπευτικό αποτέλεσμα. Δρ Αχιλ. Ε. Γεωργιάδης, Ρευματολόγος (myoskeletiko@gmail.com).
ΑΝΑΔΗΜΟΣΙΕΥΣΗ ΑΠΟ ΤΟ myoskeletiko.com *Ινομυαλγία. Ο συνδυασμός φαρμάκων ίσως φέρει καλύτερο θεραπευτικό αποτέλεσμα.* *Δρ Αχιλ. Ε. Γεωργιάδης, Ρευματολόγος (myoskeletiko@gmail.com).* O συνδυασμός Πρεγκαμπαλίνης και Ντουλοξετίνης, έχει χρησιμοποιηθεί αρκετές φορές από ιατρούς που ασχολούνται με το πρόβλημα της θεραπείας της Ινομυαλγίας, παρόλα αυτά, σύμφωνα με τους ερευνητές, είναι πρώτη φορά που δημοσιεύεται τυχαιοποιημένη διπλή τυφλή ελεγχόμενη και διασταυρούμενου σχεδιασμού μελέτη η οποία συγκρίνει το θεραπευτικό αποτέλεσμα του προαναφερόμενου συνδυασμού, αφενός με κάθε ένα από ... περισσότερα »
Σημαντική επιστολή του Διοικητικού Συμβουλίου της ΕΛΙΕΑΚΑΠ
Αθήνα, 5 Ιουλίου 2016 *ΣΥΜΜΕΤΟΧΗ ΙΑΤΡΩΝ ΠΕΔΥ ΣΤΙΣ ΕΠΙΤΡΟΠΕΣ ΚΕ.Π.Α.* Με αφορμή την εγκύκλιο του Υπ. Υγείας με αρ. πρωτ: 49056/30-6-2016, η οποία επέφερε μεγάλη αναστάτωση στους ιατρούς του Ειδικού Σώματος – μέλη της Εταιρείας μας, πραγματοποιήθηκε τη Δευτέρα 4-7-2016 συνάντηση των προέδρων της ΕΛΙΕΑΚΑΠ, Ι. Γκιουζέλη και του προέδρου της ΠΟΣΕΥΠ-ΠΕΔΥ, Π. Ψυχάρη με τον Αναπληρωτή Γενικό Γραμματέα του Υπουργείου Υγείας κ. Σταμάτη Βαρδαρό. Μελετήθηκε το θέμα της συμμετοχής στις υγειονομικές επιτροπές ΚΕ.Π.Α. των συναδέλφων μας που υπηρετούν σε μονάδες ΠΕΔΥ με τρόπο εύρυθμο για τη... περισσότερα »
Complete Tissue Submission to Increase Lymph Node Detection in Pelvic Lymph Node Packets Submitted for Patients Undergoing Radical Prostatectomy and Radical Cystectomy
Background. Pelvic lymphadenectomy has prognostic and therapeutic implications in both bladder and prostate cancer. Pelvic lymphadenectomy specimens are fatty and identification of lymph nodes (LNs) can be difficult during the grossing process. We investigated the benefit of a new grossing method requiring entire LN packet submission. Materials/Methods. We introduced a new grossing protocol requiring total… Continue reading Complete Tissue Submission to Increase Lymph Node Detection in Pelvic Lymph Node Packets Submitted for Patients Undergoing Radical Prostatectomy and Radical Cyst... περισσότερα »
Intraosseous Hibernoma in the Sacrum of an Adult
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological… Continue reading Intraosseous Hibernoma in the Sacrum of an Adult
Autoantibodies in Autoimmune Liver Diseases–Methods of Detection and Interpretation: An Update for the Reporting Pathologist
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic.… Continue reading Autoantibodies in Autoimmune Liver Diseases–Methods of Detection and Interpretation: An Update for the Reporting Pathologist
In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production
In situ estrogen biosynthesis is considered to play pivotal roles in the development and progression of human endometrial carcinoma. However, the biological roles of androgen have remained virtually unknown. Various epidemiological studies have revealed that elevated serum androgen levels are generally associated with an increased risk of developing endometrial carcinoma; however, studies directly examining androgens… Continue reading In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production
A randomized controlled study comparing a vessel sealing system with the conventional technique in axillary lymph node dissection for primary breast cancer
This study aimed to compare the efficacy and safety of the newest bipolar vessel sealing system (BVSS; LigaSure™ Small Jaw) to that of conventional technique in axillary dissection. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sDP2M via IFTTT
Editorial Harnessing primary care to reduce avoidable mortality
In 2014, almost a quarter of the 500 000 deaths among people aged less than 74 years in England and Wales could have been avoided, according to figures released by the Office for National Statistics on June 29. The report used a new definition of avoidable mortality that combined preventable deaths (mainly neoplasms) and deaths from… Continue reading Editorial Harnessing primary care to reduce avoidable mortality
Editorial Indigenous health: a worldwide focus
If you are a member of the Baka, an Indigenous tribe in Cameroon, you can expect to live until you are aged about 35 years, which is about 12 years less than for the non-Indigenous people there. In Greenland you would be better off, at 73 years, but nonetheless this figure is 9 years less… Continue reading Editorial Indigenous health: a worldwide focus
Correspondence Blood pressure lowering for cardiovascular disease
Ettehad and colleagues’ meta-analysis1 on blood pressure lowering concludes that risk reduction is proportional to the magnitude of blood pressure reduction. Thorough inspection of the data shows that none of the included trials was associated with more than 20 mm Hg difference in blood pressure reduction between treatment groups. In fact, separate inspection of the… Continue reading Correspondence Blood pressure lowering for cardiovascular disease
Correspondence Blood pressure lowering for cardiovascular disease
Dena Ettehad and colleagues1 show that the lowering of blood pressure significantly reduces vascular risk across various baseline blood pressures and comorbidities. However, this result will only be applicable to populations in whom the trials were done because the mechanisms of hypertension—and hence the responses—could be dissimilar in different cardiovascular diseases in diverse populations. from… Continue reading Correspondence Blood pressure lowering for cardiovascular disease
Correspondence Blood pressure lowering for cardiovascular disease – Authors’ reply
We agree with Collins and colleagues that the benefits of blood pressure reduction must be balanced against potential adverse events, and we encourage more consistent and comprehensive reporting of adverse outcomes. However, randomised trials of currently used regimens have not shown an increase in fatal or life-threatening side-effects from blood pressure lowering, whereas they have… Continue reading Correspondence Blood pressure lowering for cardiovascular disease – Authors’ reply
Intraosseous Hibernoma in the Sacrum of an Adult
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological […]
Autoantibodies in Autoimmune Liver Diseases–Methods of Detection and Interpretation: An Update for the Reporting Pathologist
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic. […]
In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In situ estrogen biosynthesis is considered to play pivotal roles in the development and progression of human endometrial carcinoma. However, the biological roles of androgen have remained virtually unknown. Various epidemiological studies have revealed that elevated serum androgen levels are generally associated with an increased risk of developing endometrial carcinoma; however, studies directly examining androgens […]
A randomized controlled study comparing a vessel sealing system with the conventional technique in axillary lymph node dissection for primary breast cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study aimed to compare the efficacy and safety of the newest bipolar vessel sealing system (BVSS; LigaSure™ Small Jaw) to that of conventional technique in axillary dissection. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sDP2M via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Editorial Harnessing primary care to reduce avoidable mortality
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In 2014, almost a quarter of the 500 000 deaths among people aged less than 74 years in England and Wales could have been avoided, according to figures released by the Office for National Statistics on June 29. The report used a new definition of avoidable mortality that combined preventable deaths (mainly neoplasms) and deaths from […]
Editorial Indigenous health: a worldwide focus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
If you are a member of the Baka, an Indigenous tribe in Cameroon, you can expect to live until you are aged about 35 years, which is about 12 years less than for the non-Indigenous people there. In Greenland you would be better off, at 73 years, but nonetheless this figure is 9 years less […]
Correspondence Blood pressure lowering for cardiovascular disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ettehad and colleagues’ meta-analysis1 on blood pressure lowering concludes that risk reduction is proportional to the magnitude of blood pressure reduction. Thorough inspection of the data shows that none of the included trials was associated with more than 20 mm Hg difference in blood pressure reduction between treatment groups. In fact, separate inspection of the […]
Correspondence Blood pressure lowering for cardiovascular disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dena Ettehad and colleagues1 show that the lowering of blood pressure significantly reduces vascular risk across various baseline blood pressures and comorbidities. However, this result will only be applicable to populations in whom the trials were done because the mechanisms of hypertension—and hence the responses—could be dissimilar in different cardiovascular diseases in diverse populations. from […]
Correspondence Blood pressure lowering for cardiovascular disease – Authors’ reply
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We agree with Collins and colleagues that the benefits of blood pressure reduction must be balanced against potential adverse events, and we encourage more consistent and comprehensive reporting of adverse outcomes. However, randomised trials of currently used regimens have not shown an increase in fatal or life-threatening side-effects from blood pressure lowering, whereas they have […]
Review The global response to HIV in men who have sex with men
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Gay, bisexual, and other men who have sex with men (MSM) continue to have disproportionately high burdens of HIV infection in countries of low, middle, and high income in 2016. 4 years after publication of a Lancet Series on MSM and HIV, progress on reducing HIV incidence, expanding sustained access to treatment, and realising human […]
Complete Tissue Submission to Increase Lymph Node Detection in Pelvic Lymph Node Packets Submitted for Patients Undergoing Radical Prostatectomy and Radical Cystectomy
*Background.* Pelvic lymphadenectomy has prognostic and therapeutic implications in both bladder and prostate cancer. Pelvic lymphadenectomy specimens are fatty and identification of lymph nodes (LNs) can be difficult during the grossing process. We investigated the benefit of a new grossing method requiring entire LN packet submission. *Materials/Methods.* We introduced a new grossing protocol requiring total submission of LN packets for patients undergoing radical prostatectomy (RP) or radical cystectomy (RC). A retrospective review was performed to evaluate clinical and patholo... περισσότερα »
Intraosseous Hibernoma in the Sacrum of an Adult
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological and immunohistochemical profile consistent with brown fat cells. The lesion was diagnosed as an intraosseous hibernoma. This is the 16th report in the English literature of a hibernoma occurring outside of a soft ti... περισσότερα »
Autoantibodies in Autoimmune Liver Diseases--Methods of Detection and Interpretation: An Update for the Reporting Pathologist
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic. Moreover, these autoantibodies are detected in many other pathological and nonpathological conditions. So the significance of seropositivity for these autoantibodies should be known by both the pathologists as well as the clinicians. I... περισσότερα »
TRAINING COURSE - MICROSURGERY IN THYROID SURGERY.
*TRAINING COURSE - MICROSURGERY IN THYROID SURGERY.* G Chir. 2016 Mar-Apr;37(2):96 Authors: Di Matteo G PMID: 27381699 [PubMed - as supplied by publisher] from thyroid via a.lsfakia on Inoreader http://ift.tt/29r4GLr via IFTTT
World Report Tackling rheumatic heart disease in Indigenous Australians
Rheumatic heart disease causes a large burden of ill health among Indigenous Australians. More investment is needed to prevent and manage the disease, say experts. Sophie Cousins reports. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29yI6Bs via IFTTT
Correspondence Blood pressure lowering for cardiovascular disease
In their Article (March 5, p 957),1 Dena Ettehad and colleagues conclude that there is “strong support for lowering blood pressure to systolic blood pressures less than 130 mm Hg”. While this Article could guide blood pressure-lowering treatment, we believe two issues limit its clinical use. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29yIL5y via IFTTT
Perspectives Pharmacy jar
Tastes in food change. We like our lettuce crunchy nowadays. Emma Darwin (1808–96) cooked hers for 2 hours to make a lettuce and pea soup for Charles’s delicate stomach. Such caution has long antecedents. In fact, lettuce was probably originally cultivated for its medicinal properties, although culinary use followed. It featured in the kitchens of… Continue reading Perspectives Pharmacy jar
