Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population
[image: alertIcon.gif] Publication date: Available online 30 March 2016 *Source:*Hearing Research Author(s): Kathryn Fackrell, Deborah A. Hall, Johanna G. Barry, Derek J. Hoare from #ENT via xlomafota13 on Inoreader http://ift.tt/1ZMp3Es via IFTTT
Nasogastric tube check, easy or not?
Nasogastric tube check, easy or not?: Description Our patient required nasogastric tube (NGT) feeding for poor nutritional intake. He was alert when NGT insertion occurred. This required two attempts due to coughing. On the second attempt, coughing was present throughout but settled gradually. NGT insertion may be tricky in the awake patient, especially if neurological deficits are present. Optimisation of position by sitting the patient upright and inserting the NGT horizontally and posteriorly should be undertaken. A correct insertion attempt should feel smooth, with minimal or no... περισσότερα »
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome potentially induced by allopurinol and triggered by influenza vaccine
DRESS syndrome potentially induced by allopurinol and triggered by influenza vaccine: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome (DHIS), is an acute, potentially life-threatening disease that includes skin rash, fever, haematological abnormalities and multiorgan involvement. Although its aetiopathogenesis is not exactly known, it is thought that inefficient drug detoxification leading to the accumulation of drug reactive metabolites causes autoimmune responses in skin and some internal organs, alters ...περισσότερα »
West Nile virus-associated brachial plexopathy
West Nile virus-associated brachial plexopathy: West Nile virus (WNV) is the most frequent cause of arbovirus infection in the USA. Only 20% of infected individuals are symptomatic. Less than 1% of symptomatic individuals display West Nile neuroinvasive disease. We report a rare case of WNV-associated brachial plexopathy in a young immunocompetent individual, without cerebrospinal fluid pleocytosis or encephalitis. Additionally, there was subjective and objective improvement after high-dose corticosteroids. This case adds to the clinical spectrum of WNV neuroinvasive disease. The l...περισσότερα »
Uncharacteristic rapidly enlarging swelling of the anterior maxilla: extranodal diffuse large B cell lymphoma
Clinical diagnostic dilemma in an uncharacteristic rapidly enlarging swelling of the anterior maxilla: extranodal diffuse large B cell lymphoma: Extranodal non-Hodgkin lymphoma (NHL) is infrequent in the oral cavity and constitutes 3.5% of oral cancers, and less than 2.2% of maxillofacial lymphomas. Diffuse large B cell lymphoma (DLBCL) accounts for 40% of NHL and has a 5-year survival rate of less than 30%. Early detection of extranodal NHL by dental personnel is extremely important as a delay in diagnosis can result in the cancer being diagnosed at an advanced stage and a poor pr...περισσότερα »
Digital subtraction angiography (DSA) showed severe focal stenosis in the supraclinoid ICA with free-floating thrombus (FFT)
Free-floating thrombus in a stenotic supraclinoid left internal carotid artery: Description An elderly woman presented with transient ischaemic attack (TIA) followed by aphasia the next day. MRI with angiogram showed watershed infarcts in the left middle and posterior cerebral artery territory and severe focal stenosis of the left supraclinoid internal carotid artery (ICA). She was started on aspirin 150 mg, clopidogrel 75 mg and atorvastatin 40 mg once daily. She persistently had multiple episodes of recurrent TIA despite dual antiplatelet therapy. Hence we planned to carry out dig... περισσότερα »
Transient ischaemic attack (TIA) followed by aphasia
Free-floating thrombus in a stenotic supraclinoid left internal carotid artery: Description An elderly woman presented with transient ischaemic attack (TIA) followed by aphasia the next day. MRI with angiogram showed watershed infarcts in the left middle and posterior cerebral artery territory and severe focal stenosis of the left supraclinoid internal carotid artery (ICA). She was started on aspirin 150 mg, clopidogrel 75 mg and atorvastatin 40 mg once daily. She persistently had multiple episodes of recurrent TIA despite dual antiplatelet therapy. Hence we planned to carry out dig... περισσότερα »
Osteitis fibrosa cystica of primary hyperparathyroidism
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism: Description A 28-year-old woman presented with bone pains and progressive proximal muscle weakness of 2 years duration. Examination revealed significant bony tenderness over the spine and both hips and severe proximal muscle weakness in the lower limbs. The rest of the examination was normal. Biochemical evaluation showed parathyroid hormone (PTH)-dependent hypercalcaemia (serum calcium 12.4 mg/dL (normal 8.4–10.2); PTH >1900 pg/mL (normal 8–50)). Remaining blood bone bioche... περισσότερα »
Functions of the skin...UV Rays and Thymol/Thymus vulgaris L. Extract
Effects of UV Rays and Thymol/Thymus vulgaris L. Extract in an ex vivo Human Skin Model: Morphological and Genotoxicological Assessment: Ultraviolet (UV) radiation is the major environmental factor affecting functions of the skin. Compounds rich in polyphenols, such as *Thymus vulgaris* leaf extract and thymol, have been proposed for the prevention of UV-induced skin damage. We compared the acute effects induced by UVA and UVB rays on epidermal morphology and proliferation, cytotoxicity, and genotoxicity. Normal human skin explants were obtained from young healthy women (n = 7) afte... περισσότερα »
Iodine-125-labeled DNA-Triplex-forming oligonucleotides reveal increased cyto- and genotoxic effectiveness compared to Phosphorus-32
Iodine-125-labeled DNA-Triplex-forming oligonucleotides reveal increased cyto- and genotoxic effectiveness compared to Phosphorus-32: 10.3109/09553002.2016.1160157<br>Volker Dahmen Abstract *Purpose*: The efficacy of DNA-targeting radionuclide therapies might be strongly enhanced by employing short range particle-emitters. However, the gain of effectiveness is not yet well substantiated. We compared the Auger electron emitter I-125 to the ß−-emitter P-32 in terms of biological effectiveness per decay and radiation dose when located in the close proximity to DNA using DNA Triplex...περισσότερα »
Cytologic subclassification of atypia of undetermined significance may predict thyroid nodules more likely to be malignant at surgery
Cytologic subclassification of atypia of undetermined significance may predict thyroid nodules more likely to be malignant at surgery: Background The atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda System of reporting thyroid fine-needle aspiration (FNA) includes various cytological findings considered to have a low risk of malignancy. It is still unclear if any particular subset of the cytological findings within this category carries a higher risk for malignancy requiring a more aggressive treatment plan. M... περισσότερα »
Congenital Tremor.Porcine circovirus type 2 (PCV2) antigen in the brains
Porcine circovirus type 2 expression in the brain of neonatal piglets with congenital tremor: AbstractThe present study demonstrates the presence of porcine circovirus type 2 (PCV2) antigen in the brains of neonatal piglets with congenital tremor. Piglets with clinical signs of congenital tremor were collected from a commercial swine herd for post-mortem examination. Brain tissue was collected from the piglets and was fixed in 10 % neutral buffered formalin, embedded in paraffin, and 4-μm thick sections were obtained. The PCV2 antigens were identified in the paraffin-embedded brain...περισσότερα »
Mentha piperita and Stevia rebaudiana
Polyphenolic contents and antioxidant activities of two medicinal plant species, Mentha piperita and Stevia rebaudiana , cultivated in Iran: Abstract*Mentha piperita* (peppermint) and *Stevia rebaudiana* (stevia) are now widespread in cultivation worldwide. However, reports about the contents of these two plant species are scarce. To establish the polyphenolic contents and antioxidant activity of these plants by ferric ion-reducing activity (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods, local plants were harvested in flowering stage. Samples without any previous treatment... περισσότερα »
Response to Letter : Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population
[image: alertIcon.gif] Publication date: Available online 30 March 2016 *Source:*Hearing Research Author(s): Kathryn Fackrell, Deborah A. Hall, Johanna G. Barry, Derek J. Hoare from #ENT via xlomafota13 on Inoreader http://ift.tt/1ZMp3Es via IFTTT
Scanning Electron Microscopic Examination of the Extracellular Matrix in the Decellularized Mouse and Human Cochlea
Abstract Decellularized tissues have been used to investigate the extracellular matrix (ECM) in a number of different tissues and species. Santi and Johnson JARO 14:3-15 (2013) first described the decellularized inner ear in the mouse, rat, and human using scanning thin-sheet laser imaging microscopy (sTSLIM). The purpose of the present investigation is to examine decellularized cochleas in the mouse and human at higher resolution using scanning electron microscopy (SEM). Fresh cochleas were harvested and decellularized using detergent extraction methods. Following decellularizati...περισσότερα »
Response to Letter : Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population
[image: alertIcon.gif] Publication date: Available online 30 March 2016 *Source:*Hearing Research Author(s): Kathryn Fackrell, Deborah A. Hall, Johanna G. Barry, Derek J. Hoare from #Audiology via ola Kala on Inoreader http://ift.tt/1ZMp3Es via IFTTT
A hidden second ophthalmic artery
Double ophthalmic arteries arising from the internal carotid artery: a case report of a hidden second ophthalmic artery: AbstractA case of double ophthalmic arteries arising from the internal carotid artery with unique features is reported. This case was discovered following in the course of time the progress of a thrombosis of the anterior cavernous sinus associated with a low-flow direct arteriovenous fistula of the superior ophthalmic vein. At different time points, the same patient underwent four angiographic studies and one computerized tomography with contrast medium. Angiogr... περισσότερα »
Thrombotic Microangiopathies
Management of Thrombotic Microangiopathic Hemolytic Anemias with Therapeutic Plasma Exchange: Thrombotic microangiopathies are a heterogeneous group of inherited and acquired disorders sharing a common clinical presentation of microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. These disorders have been treated with plasma exchange (TPE) based on randomized controlled trials, which found this therapy to be effective in thrombotic thrombocytopenic purpura (TTP). For the remaining disorders, low- to very low-quality evidence exists for the use of TPE. When TPE is ap... περισσότερα »
Transfusion Medicine
Transfusion Medicine: Transfusion is essential for the care of a great number of individuals with Hematologic and Oncologic disorders; pediatric and adult patients alike often require red blood cell (RBC), platelet, plasma, or other blood component transfusions during their treatment courses. Because of the close relationship between Transfusion Medicine/Apheresis and Hematology/Oncology, it is imperative that clinicians in these arenas understand the advancements and challenges in each of their respective fields. Over the course of the past few decades, the investigative and clinic... περισσότερα »
Reanimation – Die kardiopulmonale Reanimation von Kindern (Paediatric Life Support)
Reanimation – Die kardiopulmonale Reanimation von Kindern (Paediatric Life Support): Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 196-207 DOI: 10.1055/s-0041-103639 Schwerwiegende Kindernotfälle und insbesondere der kindliche Atem-Kreislauf-Stillstand sind relativ selten, doch besonders zeitkritisch. Im Vergleich zu Erwachsenen stehen bei Kindern hypoxisch bedingte Kreislaufstillstände aufgrund respiratorischer Störungen mit konsekutiver pulsloser elektrischer Aktivität oder Asystolie im Vordergrund. Die aktuellen Leitlinien 2015 des European Resuscitation Council (ERC)...περισσότερα »
Reanimation – Basismaßnahmen bei Erwachsenen und Anwendung automatischer externer Defibrillatoren
Reanimation – Basismaßnahmen bei Erwachsenen und Anwendung automatischer externer Defibrillatoren: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 178-186 DOI: 10.1055/s-0041-103637 Zeugen eines plötzlichen Herz-Kreislauf-Stillstands kommt eine Schlüsselrolle bei der Reanimation zu. Laien sollen dazu angeleitet werden, bei einem Kollabierten, der nicht reagiert und nicht bzw. nicht normal atmet, einen Herz-Kreislauf-Stillstand zu erkennen. Neben der schellen Aktivierung professioneller Hilfe sollen Laien jederzeit dazu in die Lage versetzt werden, im Bedarfsfall mit einer ...περισσότερα »
Tuberkulose in Anästhesie, Intensiv- und Notfallmedizin – Diagnostik und Umgang
Tuberkulose in Anästhesie, Intensiv- und Notfallmedizin – Diagnostik und Umgang: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 160-167 DOI: 10.1055/s-0042-101450 Tuberkulose ist in Deutschland eine seltene Erkrankung. Dies liegt an der konsequenten Behandlung und Umgebungsuntersuchung unter Aufsichtdes öffentlichen Gesundheitsdienstes, aber auch an der guten Ernährungs- und Immunitätslage der Allgemeinbevölkerung. Bedingt durch Migrationsbewegungen kann ein häufigeres Auftreten von bisher nicht diagnostizierten Tuberkulose-erkrankungen erwartet werden. Der Infektionsweg ... περισσότερα »
Scanning Electron Microscopic Examination of the Extracellular Matrix in the Decellularized Mouse and Human Cochlea
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract Decellularized tissues have been used to investigate the extracellular matrix (ECM) in a number of different tissues and species. Santi and Johnson JARO 14:3-15 (2013) first described the decellularized inner ear in the mouse, rat, and human using scanning thin-sheet laser imaging microscopy (sTSLIM). The purpose of the present investigation is to examine decellularized […]
Patienten mit angeborenem Herzfehler für nicht herzchirurgische Eingriffe – Anästhesiologisches Management
Patienten mit angeborenem Herzfehler für nicht herzchirurgische Eingriffe – Anästhesiologisches Management: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 152-158 DOI: 10.1055/s-0041-103909 In Deutschland werden jedes Jahr etwa 6000 Kinder mit angeborenen Herzfehlern (AHF) geboren. Diese Zahl ist unabhängig von der immer besser werdenden Pränataldiagnostik sehr konstant. Es besteht somit zunehmende Wahrscheinlichkeit, dass die bereits operativ versorgten Patienten mit AHF sich auch in nicht spezialisierten Krankenhäusern jederzeit vorstellen können, da viele der operativ ...περισσότερα »
Reanimation – Eine besondere Aufgabe für die Anästhesiologie
Reanimation – Eine besondere Aufgabe für die Anästhesiologie: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 176-177 DOI: 10.1055/s-0041-103651 Die kardiopulmonale Reanimation zählt ohne Frage zu den Kernkompetenzen des Anästhesisten und Intensivmediziners. In letzter Zeit ist es nicht zuletzt durch die Aktivitäten der DGAI gelungen, die entscheidende Rolle der Anästhesiologie beim Thema Wiederbelebung auch einer breiteren Öffentlichkeit zu vermitteln. Die Bad Boller Reanimationsgespräche mit der wegweisenden Initiative „10 Thesen für 10 000 Leben“ verdeutlichen die Rolle...περισσότερα »
Reanimation – Erweiterte Maßnahmen für Erwachsene (Adult Advanced Life Support)
Reanimation – Erweiterte Maßnahmen für Erwachsene (Adult Advanced Life Support): Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 188-195 DOI: 10.1055/s-0041-103638 Die erweiterten Maßnahmen zur Reanimation Erwachsener bauen auf den Basismaßnahmen der Wiederbelebung auf. Zentrales Element sind die hochwertige effektiven Thoraxkompressionen und die Vermeidung von Unterbrechungen, die bereits nach wenigen Sekunden mit einer schlechteren Patienten-Outcome verbunden sind. Der Universalalgorithmus unterscheidet die Therapie bei Kammerflimmern von der Therapie bei Asystolie bzw. ... περισσότερα »
The patient with anemia.
The patient with anemia.: Purpose of review: Anemia remains a global health issue. This review addresses the recent findings on anemia in surgical patients and its significance in perioperative setting. Recent findings: The prevalence of anemia in surgical populations is high, ranging from one-third of population to nearly 100%. Anemia is an independent, modifiable risk factor for a growing list of unfavorable events, complications and diminished functional outcomes (lasting for months following discharge), as well as a major predisposing factor for allogeneic blood transfusions. Th... περισσότερα »
Anesthesia for off-floor dental and oral surgery.
Anesthesia for off-floor dental and oral surgery.: Purpose of review: Anesthesia for dentistry is commonly performed outside the operating room. The combination of a shared airway between surgeon and anesthetist, the variety of open airway techniques, and the out-of-operating room setting often results in anxiety and avoidance of dental cases among anesthesia personnel. This review attempts to demystify dental treatment and facilitate the anesthesia provider in providing effective sedation of dental procedures performed in the nonoperating room setting. Recent findings: Specific ind... περισσότερα »
Bacterial Contamination of the Anesthesia Workplace and Efficiency of Routine Cleaning Procedures
A Prospective Cohort Study.: Abstract In this prospective cohort study, 200 decontamination (cleaning and disinfection) procedures of the anesthesia workplace either by anesthesia nurses or by specially trained housekeeping staff were monitored. Time used by housekeeping staff was shorter (1.2 +/- 0.1 vs 2.6 +/- 0.2 minutes on average, data are mean +/- SEM; P < 0.0001) with less visible marker spots (14.4 +/- 0.68 [55%] vs 17.3 +/- 0.75 [66.7%] on average, data are mean +/- SEM; P = 0.0041), and the bacterial load showed a decrease ([approximately equal to]67%, P < 0.0001) comp...περισσότερα »
Mesenchymal Stem Cells Application on The Distracted Bone Microstructure
An Experimental Study via Oral and Maxillofacial Surgery Publication date: Available online 29 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Yasser N. El Hadidi, Marwa El Kassaby, Salah Abd El fatah Ahmed, Nahed Khamis PurposeDistraction osteogenesis (DO) is a surgical technique used to regenerate bone. The aim of this study was to improve the bone quality and quantity during DO by the addition of mesenchymal stem cells (MSCs).MethodologyThe study was conducted on 12 goats divided into study and control groups. In group A (the study group), DO was aided with ...περισσότερα »
Nasal forms following secondary correction of cleft lip nose deformities using extended spreader cartilage graft with a cross-lap joint technique
Clinical and three-dimensional analyses of via Oral and Maxillofacial Surgery Publication date: Available online 30 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Norifumi Nakamura, Takako Okawachi, Kouzou Matsumoto, Namiko Kimura, Toshiro Kibe, Takao Fuchigami PurposeA surgical strategy for definitive cleft lip nasal correction that stably provides symmetrical and natural nasal forms has not been established to date. The purpose of this study was to describe our surgical techniques and three-dimensional (3D) assessment results following the definitive correc... περισσότερα »
Risk factors for pedicle flap complications in elderly patients who underwent oral and maxillofacial reconstruction
Chinese via Oral and Maxillofacial Surgery Publication date: Available online 30 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Zao Fang, Zhuowei Tian, Chenping Zhang, Jian Sun, Jingzhou Hu, Yue He PurposeTo determine the risk factors for pedicle flap complications in elderly patients who underwent oral and maxillofacial reconstruction.MethodsThe investigators designed and implemented a retrospective cohort study and enrolled a sample of patients 75 years of age and older who underwent resection of oral and maxillofacial tumors and pedicle flap reconstruction... περισσότερα »
Early Postoperative Malignant Subcutaneous Emphysema
Report and Review: Abstract BackgroundSubcutaneous emphysema is defined as presence of air or gas in subcutaneous tissue layer. It may be localized or generalized due to various aetiological factors. Although SE and pneumomediastinum are self-limiting conditions, life-threatening complications may develop. Escape of air into both pleural cavity causing bilateral pneumothorax and tension pneumothorax can be termed as malignant emphysema. PurposeTo report a case of malignant generalized subcutaneous emphysema in early postoperative phase following palatoplasty. Case ReportA 2...περισσότερα »
Distraction Osteogenesis for Management of Severe OSA in Pierre Robin Sequence: An Approach to Elude Tracheostomy in Infants
Distraction Osteogenesis for Management of Severe OSA in Pierre Robin Sequence: An Approach to Elude Tracheostomy in Infants: Abstract BackgroundSevere obstructive sleep apnoea (OSA) is a life threatening condition associated with Pierre Robin sequence (PRS) due to mandibular micrognathia and glossoptosis. Often these patients require tracheostomy at an early age which has high morbidity. Distraction osteogenesis (DO) is an accepted method of treatment for patients with hypoplastic mandible to achieve mandibular lengthening without need for a bone graft. It has also been used in r...περισσότερα »
Scanning Electron Microscopic Examination of the Extracellular Matrix in the Decellularized Mouse and Human Cochlea
Abstract Decellularized tissues have been used to investigate the extracellular matrix (ECM) in a number of different tissues and species. Santi and Johnson JARO 14:3-15 (2013) first described the decellularized inner ear in the mouse, rat, and human using scanning thin-sheet laser imaging microscopy (sTSLIM). The purpose of the present investigation is to examine decellularized cochleas in the mouse and human at higher resolution using scanning electron microscopy (SEM). Fresh cochleas were harvested and decellularized using detergent extraction methods. Following decellularizati...περισσότερα »
Is there a need for non-drug treatments in headaches?
from #ENT via xlomafota13 on Inoreader http://ift.tt/1UE0Cd4 via IFTTT
Spontaneous rupture of an internal laryngocele after neck dissection
: a rare complication: We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications.
Possible mast cell activation syndrome in a patient undergoing long-term hemodialysis
Possible mast cell activation syndrome in a patient undergoing long-term hemodialysis: Mast cell activation syndrome (MCAS) is the clinical presentation of acute episodes of mast cell mediator–induced symptoms without an elevation in the number of mast cells in the tissues or elevations of tryptase greater than 20 ng/mL.1 Serum tryptase is a biomarker of mast cell activation and is seen in MCAS.2 Serum tryptase in patients undergoing hemodialysis is elevated to above the 95th percentile and correlated with the severity of pruritus.3 We present a case of possible MCAS due to long-ter... περισσότερα »
Patient knowledge and expectations in endoscopic sinus surgery
Patient knowledge and expectations in endoscopic sinus surgery: Background The potential for patient misconceptions about endoscopic sinus surgery (ESS) has implications for the informed consent process. An understanding of patients’ baseline knowledge and sources of information regarding ESS would improve surgeons’ ability to counsel patients preoperatively and provide effective educational materials. Methods A prospective patient survey was performed at 2 independent tertiary care medical centers. Patients who were offered ESS as part of routine rhinology care were queried about e... περισσότερα »
Agger-bullar classification (ABC) of the frontal sinus drainage pathway
: validation in a preclinical setting: Background The anatomy of structures surrounding the frontal sinus drainage pathway (FSDP) is extremely complex and challenging for endoscopic sinus surgeons. The anatomical nomenclature of this area reflects this complexity and lack of agreement regarding anatomical variants of this region is present in the literature. This work presents a new classification system of the air spaces surrounding the FSDP, called the agger-bullar classification (ABC), and compares it with the most widely used anatomical classification of the frontoethmoidal reg... περισσότερα »
Predictive factors in patients undergoing endoscopic sinus surgery for odontogenic sinusitis
Predictive factors in patients undergoing endoscopic sinus surgery for odontogenic sinusitis: Background Odontogenic sinusitis (OS) presents a therapeutic dilemma. Evidence is lacking whether dental treatment alone is sufficient or whether patients will eventually require endoscopic sinus surgery (ESS). Our aim was to identify predictors of OS patients undergoing ESS. Methods Retrospective review performed of OS patients (n = 43) analyzing multiple factors including age, sex, symptoms, prior dental procedures, treatment, diabetes, immunosuppression, smoking history, retained dental ...περισσότερα »
Differences in the paranasal sinuses between germ-free and pathogen-free mice
Differences in the paranasal sinuses between germ-free and pathogen-free mice: Background The role of bacteria in the etiology of chronic rhinosinusitis (CRS) is not fully understood. Commensal bacteria may have a significant impact on the development of normal paranasal sinus anatomy and mucosal immunity, as they do in the gut. Studying the paranasal sinuses of germ-free (GF) mice may provide some insight into the effect of commensal bacteria on sinus structure and mucosal function. Methods The paranasal sinuses of 5 GF mice were compared to 5 pathogen-free normal mice. Mice heads... περισσότερα »
Rosacea
Rosacea: A chronic skin disease that causes persistent redness over the areas of the face and nose that normally blush: mainly the forehead, the chin, and the lower half of the nose. The tiny blood vessels in these areas enlarge (dilate) and become more visible through the skin, appearing like tiny red lines (telangiectasias). Pimples… Continue reading Rosacea
Is there a need for non-drug treatments in headaches?
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UE0Cd4 via IFTTT
Seizure outcome following medical treatment of mesial temporal lobe epilepsy: Clinical phenotypes and prognostic factors
Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Igor Kuzmanovski, Emilija Cvetkovska, Marija Babunovska, Gordana Kiteva Trencevska, Biljana Kuzmanovska, Bojan Boshkovski, Rozalinda Isjanovska ObjectiveSurveys on mesial temporal lobe epilepsy (MTLE) repeatedly demonstrate that seizures are commonly resistant to antiepileptic drugs (AED), but patients usually came from third-level epilepsy centers, making the medically… Continue reading Seizure outcome following medical treatment of mesial temporal lobe epilepsy: Clinical phenotypes and pro...περισσότερα »
Stent-assisted coiling versus coiling alone of ruptured anterior communicating artery aneurysms: A single-center experience
Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Lianghao Fan, Xianxi Tan, Ye Xiong, Kuang Zheng, Zequn Li, Dajun Liu, Ming Zhong, Bing Zhao ObjectiveEndovascular coiling of anterior communicating artery (ACoA) aneurysms has evolved; however, stent-assisted coiling of ruptured aneurysms remains controversial. We aimed to compare periprocedural complications, angiographic and clinical outcomes… Continue reading Stent-assisted coiling versus coiling alone of ruptured anterior communicating artery aneurysms: A single-center experience
Decreased CSF output as a clinical indicator of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Christine Hammer, Badih Daou, Nohra Chalouhi, Robert M. Starke, Lina Ya’qoub, Nikolaos Mouchtouris, Sravanthi Koduri, Stavropoula Tjoumakaris, Robert H. Rosenwasser, Pascal Jabbour ObjectiveVasospasm is a significant cause of morbidity and mortality among those with aneurysmal subarachnoid hemorrhage (aSAH). Treating increased intracranial pressure by drainage… Continue reading Decreased CSF output as a clinical indicator of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
Reappraisal of GIP Pharmacology for Metabolic Diseases
Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type 2 diabetes (T2D) and obesity due to their actions in lowering blood glucose and body weight. Despite similarities to GLP-1, glucose-dependent insulinotropic polypeptide (GIP) has not been extensively pursued as a medical treatment for T2D. This is largely based on observations of diminished… Continue reading Reappraisal of GIP Pharmacology for Metabolic Diseases
Insights into the C-terminal Peptide Binding Specificity of the PDZ domain of neuronal Nitric Oxide Synthase. Characterization of the Interaction with the tight-junction protein Claudin-3 Cell Biology
Neuronal Nitric Oxide synthase, unlike its endothelial and inducible counterparts, displays a PDZ (PSD-95/Dlg/ZO-1) domain located at its N-terminus involved in subcellular targeting. The C-termini of various cellular proteins insert within the binding groove of this PDZ domain and determine the subcellular distribution of nNOS. The molecular mechanisms underlying these interactions are poorly understood since… Continue reading Insights into the C-terminal Peptide Binding Specificity of the PDZ domain of neuronal Nitric Oxide Synthase. Characterization of the Interaction with the ti... περισσότερα »
Extracellular vesicles isolated from brains of rTg4510 mice seed tau aggregation in a threshold-dependent manner Molecular Bases of Disease
The microtubule-associated protein tau has a critical role in Alzheimer’s disease and related tauopathies. There is accumulating evidence that tau aggregates spread and replicate in a prion-like manner, with the uptake of pathological tau seeds causing misfolding and aggregation of monomeric tau in recipient cells. Here, we focused on small extracellular vesicles enriched for exosomes,… Continue reading Extracellular vesicles isolated from brains of rTg4510 mice seed tau aggregation in a threshold-dependent manner Molecular Bases of Disease
Protein Kinase D and G{beta}{gamma} Mediate Agonist-Evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane Cell Biology
Agonist-evoked endocytosis of G protein-coupled receptors (GPCRs) has been extensively studied. The mechanisms by which agonists stimulate mobilization and plasma membrane translocation of GPCRs from intracellular stores are unexplored. Protease-activated receptor-2 (PAR2) traffics to lysosomes, and sustained protease signaling requires mobilization and plasma membrane trafficking of PAR2 from Golgi stores. We evaluated the contribution of… Continue reading Protein Kinase D and G{beta}{gamma} Mediate Agonist-Evoked Translocation of Protease-activated Receptor-2 from the Golgi Appara... περισσότερα »
Functional and Structural Characterization of Bub3-BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells Cell Biology
The spindle assembly checkpoint (SAC) is an essential safeguarding mechanism devised to ensure equal chromosome distribution in daughter cells upon mitosis. The proteins Bub3 and BubR1 are key components of the mitotic checkpoint complex (MCC), an essential part of the molecular machinery on which the SAC relies. In the present work we have performed a… Continue reading Functional and Structural Characterization of Bub3-BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells Cell Biology
Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face
Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face: *Condition*: Lentigo Maligna *Intervention*: Drug: Picato gel *Sponsor*: Centre Hospitalier Universitaire de Nice Non-invasive lentigo maligna (LM) is characterized by an in situ proliferation of melanoma cells, limited to the epidermis. It is found most commonly on the head and neck of elderly persons, with a peak incidence in the seventh or eighth decade. If untreated, it may develop into invasive melanoma. The gold standard treatment for LM is surgery using a 5-10 mm margin. However, the... περισσότερα »
Low-Level Laser Therapy for Prevention of Oral Mucositis
Low-Level Laser Therapy for Prevention of Oral Mucositis: *Condition*: Mucositis *Intervention*: Device: Low Level Laser Therapy *Sponsors*: Barbara Ann Karmanos Cancer Institute; National Cancer Institute (NCI) ArmsAssigned Interventions Experimental: Experimental: Low Level Laser Therapy Patients meeting the eligibility criteria will be enrolled to receive prophylactic LLLT in addition to standard of care measures for oral mucositis or other toxicity of therapy. The radiation and chemotherapy dose, schedule, modality, technique, and any required adjustments will not be ... περισσότερα »
Head and neck cancer : Macroeconomic consequences and the role of the head and neck surgeon
in South Asia [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Head and neck cancer constitutes a substantial portion of the burden of disease in South Asia, and there is an undersupply of surgical capacity in this region. The purpose of this study was to estimate the economic welfare losses due to head and neck cancer in India, Pakistan, and Bangladesh in 2010. Methods We used publicly available estimates of head and neck cancer morbidity and mortality along with a concept termed the value of a statistical life to estimate economic welfare losses in the afo... περισσότερα »
Poor prognosis in human papillomavirus–positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α
Poor prognosis in human papillomavirus–positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Hypoxia induces stabilization of the transcription factor HIF-1alpha (HIF-1α), associated with (chemo-)radiotherapy resistance in oropharyngeal squamous cell carcinoma (SCC). We investigated the effect of HIF-1α expression on survival in relation to human papillomavirus (HPV) status in oropharyngeal SCC. Methods We conducted an immunohistochemical analysis of HIF-1α protein expres... περισσότερα »
Structural insight in the toppling mechanism of an energy-coupling factor transporter
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Article Prokaryotes use energy-coupling factor transporters to uptake required micronutrients and an unusual toppling mechanism has been proposed for their function. Here, the authors provide structural support for this mechanism, allowing direct visualization of the toppled state. Nature Communications doi: 10.1038/ncomms11072 Authors: Lotteke J. Y. M. Swier, Albert Guskov, Dirk J. Slotboom from #Medicine-SfakianakisAlexandros via […]
Rosacea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Rosacea: A chronic skin disease that causes persistent redness over the areas of the face and nose that normally blush: mainly the forehead, the chin, and the lower half of the nose. The tiny blood vessels in these areas enlarge (dilate) and become more visible through the skin, appearing like tiny red lines (telangiectasias). Pimples […]
Reappraisal of GIP Pharmacology for Metabolic Diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type 2 diabetes (T2D) and obesity due to their actions in lowering blood glucose and body weight. Despite similarities to GLP-1, glucose-dependent insulinotropic polypeptide (GIP) has not been extensively pursued as a medical treatment for T2D. This is largely based on observations of diminished […]
Time trends in statin utilisation and coronary mortality in Western European countries
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Objectives To determine whether there is a relation between statin utilisation and coronary heart disease (CHD) mortality in populations with different levels of coronary risk, and whether the relation changes over time. Design Ecological study using national databases of dispensed medicines and mortality rates. Setting Western European countries with similar public health systems. Main outcome […]
Effects of prehospital hypothermia on transfusion requirements and outcomes: a retrospective observatory trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Objectives Prehospital hypothermia is defined as a core temperature <36.0°C and has been shown to be an independent risk factor for early death in patients with trauma. In a retrospective study, a possible correlation between the body temperature at the time of admission to the emergency room and subsequent in-hospital transfusion requirements and the in-hospital […]
Association of socioeconomic status change between infancy and adolescence, and blood pressure, in South African young adults: Birth to Twenty Cohort
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Objective Social epidemiology models suggest that socioeconomic status (SES) mobility across the life course affects blood pressure. The aim of this study was to investigate the association between SES change between infancy and adolescence, and blood pressure, in young adults, and the impact of early growth on this relationship. Setting Data for this study were […]
Applying appropriate-use criteria to cardiac revascularisation in India
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Objectives The high prevalence of coronary heart disease and dramatic growth of cardiac interventions in India motivate an evaluation of the appropriateness of coronary revascularisation procedures in India. Although, appropriate-use criteria (AUC) have been used to analyse the appropriateness of cardiovascular care in the USA, they are yet to be applied to care in India. […]
Optimising text messaging to improve adherence to web-based smoking cessation treatment: a randomised control trial protocol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Introduction Millions of smokers use the Internet for smoking cessation assistance each year; however, most smokers engage minimally with even the best designed websites. The ubiquity of mobile devices and their effectiveness in promoting adherence in other areas of health behaviour change make them a promising tool to address adherence in Internet smoking cessation interventions. […]
Less is more: a project to reduce the number of PIMs (potentially inappropriate medications) on an elderly care ward
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Potentially inappropriate prescribing in healthcare of the elderly (HCE) is associated with avoidable adverse drug events (ADEs).1,2 A recent set of prescribing criteria has been designed and validated, called «Screening Tool of Older Persons’ Prescriptions» (STOPP), to rationalise prescribing in hospitalised patients on HCE wards.1,3 The aim of this quality improvement project was to identify […]
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SzE1ur via […]
Insights into the C-terminal Peptide Binding Specificity of the PDZ domain of neuronal Nitric Oxide Synthase. Characterization of the Interaction with the tight-junction protein Claudin-3 Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Neuronal Nitric Oxide synthase, unlike its endothelial and inducible counterparts, displays a PDZ (PSD-95/Dlg/ZO-1) domain located at its N-terminus involved in subcellular targeting. The C-termini of various cellular proteins insert within the binding groove of this PDZ domain and determine the subcellular distribution of nNOS. The molecular mechanisms underlying these interactions are poorly understood since […]
Extracellular vesicles isolated from brains of rTg4510 mice seed tau aggregation in a threshold-dependent manner Molecular Bases of Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
The microtubule-associated protein tau has a critical role in Alzheimer’s disease and related tauopathies. There is accumulating evidence that tau aggregates spread and replicate in a prion-like manner, with the uptake of pathological tau seeds causing misfolding and aggregation of monomeric tau in recipient cells. Here, we focused on small extracellular vesicles enriched for exosomes, […]
An alternative to the sternal notch placement of electrodes for acquiring a 12-lead ECG
http://brightcove.vo.llnwd.net/v1/uds/pd/963482465001/201503/86/963482465001_4122361604001_4122347009001.mp4?pubId=963482465001&videoId=4122347009001
A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60.
A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60.: Hum Genet. 2016 Mar 29; Authors: Ben Said M, Grati M, Ishimoto T, Zou B, Chakchouk I, Ma Q, Yao Q, Hammami B, Yan D, Mittal R, Nakamichi N, Ghorbel A, Neng L, Tekin M, Shi XR, Kato Y, Masmoudi S, Lu Z, Hmani M, Liu X Abstract The high prevalence/incidence of hearing loss (HL) in humans makes it the most common sensory defect. The majority of the cases are of genetic origin. Non-syndromic hereditary HL is extremely heter... περισσότερα »
Newborn Hearing Screening
Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU: by Pei-Chun Li, Wei-I Chen, Chih-Ming Huang, Ching-Ju Liu, Hsiu-wen Chang, Hung-Ching Lin Objectives To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevalence of hearing loss in neonatal population; and 4) try to...περισσότερα »
Production of Idiomatic Utterances Following Left- and Right-Hemisphere Damage: Acoustic Studies
Production of Korean Idiomatic Utterances Following Left- and Right-Hemisphere Damage: Acoustic Studies: Purpose This study investigates the effects of left- and right-hemisphere damage (LHD and RHD) on the production of idiomatic or literal expressions utilizing acoustic analyses. Method Twenty-one native speakers of Korean with LHD or RHD and in a healthy control (HC) group produced 6 ditropically ambiguous (idiomatic or literal) sentences in 2 different speech tasks: elicitation and repetition. Utterances were analyzed using durational and fundamental-frequency (F0) measures. ... περισσότερα »
Scanning Electron Microscopic Examination of the Extracellular Matrix in the Cochlea
Decellularized Mouse and Human Cochlea: AbstractDecellularized tissues have been used to investigate the extracellular matrix (ECM) in a number of different tissues and species. Santi and Johnson JARO 14:3-15 (2013) first described the decellularized inner ear in the mouse, rat, and human using scanning thin-sheet laser imaging microscopy (sTSLIM). The purpose of the present investigation is to examine decellularized cochleas in the mouse and human at higher resolution using scanning electron microscopy (SEM). Fresh cochleas were harvested and decellularized using detergent extract...περισσότερα »
Drug Delivery Tool in Anaplastic Thyroid Cancer
•Doxorubicin-Loaded Nanobubbles Combined with Extracorporeal Shock Waves: Basis for a New Drug Delivery Tool in Anaplastic Thyroid Cancer Thyroid (doi:10.1089/thy.2015.0342) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Francesca Marano,1* Monica Argenziano,2* Roberto Frairia,1 Aloe Adamini,1 Ornella Bosco,1 Letizia Rinella,1 Nicoletta Fortunati,3 Roberta Cavalli,2 and Maria Graziella Catalano1 1Department of Medical Sciences, University of Turin, Turin, Italy. 2Department of Drug Science and Technology, University of Turin, Turin... περισσότερα »
Quantitative Trait Locus Analysis of Mating Behavior and Male Sex Pheromones in Nasonia Wasps
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 42 δευτερόλεπτα
A major focus in speciation genetics is to identify the chromosomal regions and genes that reduce hybridization and gene flow. We investigated the genetic architecture of mating behavior in the parasitoid wasp species pair *Nasonia giraulti* and *Nasonia oneida* that exhibit strong prezygotic isolation. Behavioral analysis showed that *N. oneida* females had consistently higher latency times and broke off the mating sequence more often in the mounting stage when confronted with N. giraulti males compared with males of their own species. *N. oneida* males produce a lower quantity of... περισσότερα »
DREADD-induced Activation of Subfornical Organ Neurons Stimulates Thirst and Salt Appetite
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 42 δευτερόλεπτα
The subfornical organ (SFO) plays a pivotal role in body fluid homeostasis through its ability to integrate neurohumoral signals and subsequently alter behavior, neuroendocrine function and autonomic outflow. The purpose of the present study was to evaluate whether selective activation of SFO neurons using virally-mediated expression of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) stimulated thirst and salt appetite. Male C57Bl/6 mice (12-15 weeks) received an injection of rAAV2-CaMKII-HA-hM3D(Gq)-IRES-mCitrine targeted at the SFO. At 2 wks later, acute inj...περισσότερα »
Patterns of Genome-Wide Variation in Glossina fuscipes fuscipes Tsetse Flies from Uganda
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 42 δευτερόλεπτα
The tsetse fly *Glossina fuscipes fuscipes* (*Gff*) is the insect vector of the two forms of Human African Trypanosomiasis (HAT) that exist in Uganda. Understanding *Gff* population dynamics and the underlying genetics of epidemiologically relevant phenotypes is key to reducing disease transmission. Using ddRAD sequence technology, complemented with whole-genome sequencing, we developed a panel of ~73,000 single-nucleotide polymorphisms distributed across the *Gff* genome that can be used for population genomics and to perform Genome-Wide-Association studies. We used these markers... περισσότερα »
Receptive field size, chemical and thermal responses and fiber conduction velocity of rat chorda tympani geniculate ganglion neurons
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 42 δευτερόλεπτα
Afferent chorda tympani (CT) fibers innervating taste and somatosensory receptors in fungiform papillae have neuron cell bodies in the geniculate ganglion (GG). The GG/CT fibers branch in the tongue to innervate taste buds in several fungiform papillae. To investigate receptive field characteristics of GG/CT neurons we recorded extracellular responses from GG cells to application of chemical and thermal stimuli. Receptive field size was mapped by electrical stimulation of individual fungiform papillae. Response latency to electrical stimulation was used to determine fiber conducti... περισσότερα »
Network Feedback Regulates Motor Output across a Range of Modulatory Neuron Activity
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 42 δευτερόλεπτα
Modulatory projection neurons alter network neuron synaptic and intrinsic properties to elicit multiple different outputs. Sensory and other inputs elicit a range of modulatory neuron activity which is further shaped by network feedback. Yet little is known regarding how the impact of network feedback on modulatory neurons regulates network output across a physiological range of modulatory neuron activity. Identified network neurons, a fully described connectome, and a well-characterized, identified modulatory projection neuron enabled us to address this issue in the crab (Cancer ... περισσότερα »
Thyroid hormone (TH) plays a key role in the developing brain, including the cerebellum.
•Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors Thyroid Posted online on March 23, 2016. (doi:10.1089/thy.2015.0034) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Izuki Amano,1 Yusuke Takatsuru,1 Syutaro Toya,1 Asahi Haijima,1 Toshiharu Iwasaki,1 Helmut Grasberger,2,3 Samuel Refetoff,2,4,5 and Noriyuki Koibuchi1 1Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan. 2Department of Medicine, The University of Chicago, Chicago, Illinois. 3Division of Gast... περισσότερα »
Thyroid Incidentalomas
•Developing a Registry for Thyroid Incidentalomas: Lessons Learned and the Path Forward Thyroid Posted online on March 30, 2016. (doi:10.1089/thy.2015.0390) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Louise Davies,1,2,3 Erin Pichiotino,4 William C Black,3,5,6 and Anna N.A. Tosteson3,6,7 1VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, Vermont. 2Department of Surgery, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. 3Dartmouth Institute for Health Policy and Clinical Practic... περισσότερα »
Conventional Papillary Thyroid Carcinoma Carrying the BRAFV600E Mutation and BRAF Pseudogene
•Clinical Manifestations and Gene Expression in Patients with Conventional Papillary Thyroid Carcinoma Carrying the *BRAFV600E* Mutation and *BRAF Pseudogene* Thyroid Posted online on March 30, 2016. (doi:10.1089/thy.2015.0044) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Jiunn-Diann Lin,1,2,3 Shuai-Shuai Fu,4 Jui-Yu Chen,5 Chen-Hsen Lee,5 Wing-Keung Chau,6 Chao-Wen Cheng,1 Yuan-Hung Wang,1,7 Yuh-Feng Lin,1,8 Wen-Fang Fang,9 and Kam-Tsun Tang10 1Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical Univers... περισσότερα »
Rosacea
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Rosacea: A chronic skin disease that causes persistent redness over the areas of the face and nose that normally blush: mainly the forehead, the chin, and the lower half of the nose. The tiny blood vessels in these areas enlarge (dilate) and become more visible through the skin, appearing like tiny red lines (telangiectasias). Pimples […]
Is there a need for non-drug treatments in headaches?
from #ENT via xlomafota13 on Inoreader http://ift.tt/1UE0Cd4 via IFTTT
Is there a need for non-drug treatments in headaches?
from #ENT via xlomafota13 on Inoreader http://ift.tt/1UE0Cd4 via IFTTT
Is there a need for non-drug treatments in headaches?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UE0Cd4 via IFTTT
Influence of meteorological data on sun tolerance in patients with erythropoietic protoporphyria in France
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Background Erythropoietic protoporphyria (EPP) is a rare metabolic disorder, characterized by photosensitivity, caused by errors of the hæm biosynthetic pathway. Avoidance of sun exposure is recommended; however, some patients suggested a paradoxical improvement of symptoms when they move to sunny areas. Objectives In a national French study, we sought to investigate the influence of […]
Time trends in statin utilisation and coronary mortality in Western European countries
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To determine whether there is a relation between statin utilisation and coronary heart disease (CHD) mortality in populations with different levels of coronary risk, and whether the relation changes over time. Design Ecological study using national databases of dispensed medicines and mortality rates. Setting Western European countries with similar public health systems. Main outcome […]
Effects of prehospital hypothermia on transfusion requirements and outcomes: a retrospective observatory trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives Prehospital hypothermia is defined as a core temperature <36.0°C and has been shown to be an independent risk factor for early death in patients with trauma. In a retrospective study, a possible correlation between the body temperature at the time of admission to the emergency room and subsequent in-hospital transfusion requirements and the in-hospital […]
Association of socioeconomic status change between infancy and adolescence, and blood pressure, in South African young adults: Birth to Twenty Cohort
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Social epidemiology models suggest that socioeconomic status (SES) mobility across the life course affects blood pressure. The aim of this study was to investigate the association between SES change between infancy and adolescence, and blood pressure, in young adults, and the impact of early growth on this relationship. Setting Data for this study were […]
Applying appropriate-use criteria to cardiac revascularisation in India
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives The high prevalence of coronary heart disease and dramatic growth of cardiac interventions in India motivate an evaluation of the appropriateness of coronary revascularisation procedures in India. Although, appropriate-use criteria (AUC) have been used to analyse the appropriateness of cardiovascular care in the USA, they are yet to be applied to care in India. […]
Optimising text messaging to improve adherence to web-based smoking cessation treatment: a randomised control trial protocol
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction Millions of smokers use the Internet for smoking cessation assistance each year; however, most smokers engage minimally with even the best designed websites. The ubiquity of mobile devices and their effectiveness in promoting adherence in other areas of health behaviour change make them a promising tool to address adherence in Internet smoking cessation interventions. […]
Less is more: a project to reduce the number of PIMs (potentially inappropriate medications) on an elderly care ward
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Potentially inappropriate prescribing in healthcare of the elderly (HCE) is associated with avoidable adverse drug events (ADEs).1,2 A recent set of prescribing criteria has been designed and validated, called «Screening Tool of Older Persons’ Prescriptions» (STOPP), to rationalise prescribing in hospitalised patients on HCE wards.1,3 The aim of this quality improvement project was to identify […]
Seizure outcome following medical treatment of mesial temporal lobe epilepsy: Clinical phenotypes and prognostic factors
Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Igor Kuzmanovski, Emilija Cvetkovska, Marija Babunovska, Gordana Kiteva Trencevska, Biljana Kuzmanovska, Bojan Boshkovski, Rozalinda Isjanovska ObjectiveSurveys on mesial temporal lobe epilepsy (MTLE) repeatedly demonstrate that seizures are commonly resistant to antiepileptic drugs (AED), but patients usually came from third-level epilepsy centers, making the medically refractory population larger. The aim of our study is to evaluate patterns of seizure control and prognostic factors of g...περισσότερα »
Stent-assisted coiling versus coiling alone of ruptured anterior communicating artery aneurysms: A single-center experience
[image: alertIcon.gif] Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Lianghao Fan, Xianxi Tan, Ye Xiong, Kuang Zheng, Zequn Li, Dajun Liu, Ming Zhong, Bing Zhao ObjectiveEndovascular coiling of anterior communicating artery (ACoA) aneurysms has evolved; however, stent-assisted coiling of ruptured aneurysms remains controversial. We aimed to compare periprocedural complications, angiographic and clinical outcomes after stent-assisted coiling with coiling alone of ruptured ACoA aneurysms.MethodsWe performed a retrospective review of con... περισσότερα »
Decreased CSF output as a clinical indicator of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
[image: S03038467.gif] Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Christine Hammer, Badih Daou, Nohra Chalouhi, Robert M. Starke, Lina Ya'qoub, Nikolaos Mouchtouris, Sravanthi Koduri, Stavropoula Tjoumakaris, Robert H. Rosenwasser, Pascal Jabbour ObjectiveVasospasm is a significant cause of morbidity and mortality among those with aneurysmal subarachnoid hemorrhage (aSAH). Treating increased intracranial pressure by drainage of cerebral spinal fluid through an external ventriculostomy is routine practice. The objective of this study...περισσότερα »
Influence of meteorological data on sun tolerance in patients with erythropoietic protoporphyria in France
Summary Background Erythropoietic protoporphyria (EPP) is a rare metabolic disorder, characterized by photosensitivity, caused by errors of the hæm biosynthetic pathway. Avoidance of sun exposure is recommended; however, some patients suggested a paradoxical improvement of symptoms when they move to sunny areas. Objectives In a national French study, we sought to investigate the influence of… Continue reading Influence of meteorological data on sun tolerance in patients with erythropoietic protoporphyria in France
Time trends in statin utilisation and coronary mortality in Western European countries
Objectives To determine whether there is a relation between statin utilisation and coronary heart disease (CHD) mortality in populations with different levels of coronary risk, and whether the relation changes over time. Design Ecological study using national databases of dispensed medicines and mortality rates. Setting Western European countries with similar public health systems. Main outcome… Continue reading Time trends in statin utilisation and coronary mortality in Western European countries
Effects of prehospital hypothermia on transfusion requirements and outcomes: a retrospective observatory trial
Objectives Prehospital hypothermia is defined as a core temperature <36.0°C and has been shown to be an independent risk factor for early death in patients with trauma. In a retrospective study, a possible correlation between the body temperature at the time of admission to the emergency room and subsequent in-hospital transfusion requirements and the in-hospital… Continue reading Effects of prehospital hypothermia on transfusion requirements and outcomes: a retrospective observatory trial
Association of socioeconomic status change between infancy and adolescence, and blood pressure, in South African young adults: Birth to Twenty Cohort
Objective Social epidemiology models suggest that socioeconomic status (SES) mobility across the life course affects blood pressure. The aim of this study was to investigate the association between SES change between infancy and adolescence, and blood pressure, in young adults, and the impact of early growth on this relationship. Setting Data for this study were… Continue reading Association of socioeconomic status change between infancy and adolescence, and blood pressure, in South African young adults: Birth to Twenty Cohort
Applying appropriate-use criteria to cardiac revascularisation in India
Objectives The high prevalence of coronary heart disease and dramatic growth of cardiac interventions in India motivate an evaluation of the appropriateness of coronary revascularisation procedures in India. Although, appropriate-use criteria (AUC) have been used to analyse the appropriateness of cardiovascular care in the USA, they are yet to be applied to care in India.… Continue reading Applying appropriate-use criteria to cardiac revascularisation in India
Optimising text messaging to improve adherence to web-based smoking cessation treatment: a randomised control trial protocol
Introduction Millions of smokers use the Internet for smoking cessation assistance each year; however, most smokers engage minimally with even the best designed websites. The ubiquity of mobile devices and their effectiveness in promoting adherence in other areas of health behaviour change make them a promising tool to address adherence in Internet smoking cessation interventions.… Continue reading Optimising text messaging to improve adherence to web-based smoking cessation treatment: a randomised control trial protocol
Less is more: a project to reduce the number of PIMs (potentially inappropriate medications) on an elderly care ward
Potentially inappropriate prescribing in healthcare of the elderly (HCE) is associated with avoidable adverse drug events (ADEs).1,2 A recent set of prescribing criteria has been designed and validated, called «Screening Tool of Older Persons’ Prescriptions» (STOPP), to rationalise prescribing in hospitalised patients on HCE wards.1,3 The aim of this quality improvement project was to identify… Continue reading Less is more: a project to reduce the number of PIMs (potentially inappropriate medications) on an elderly care ward
Greater body mass independently predicts less radiographic progression on X-ray and MRI over 1–2 years
Annals of the rheumatic diseases from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1q461NU via IFTTT
Neuropsychiatry and white matter microstructure in Huntington’s disease
Journal of Huntington’s disease from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1SzzEzv via IFTTT
Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments
Proceedings of the National Academy of Sciences of the United States of America from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1q45Z8w via IFTTT
Protein Kinase D and G{beta}{gamma} Mediate Agonist-Evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Agonist-evoked endocytosis of G protein-coupled receptors (GPCRs) has been extensively studied. The mechanisms by which agonists stimulate mobilization and plasma membrane translocation of GPCRs from intracellular stores are unexplored. Protease-activated receptor-2 (PAR2) traffics to lysosomes, and sustained protease signaling requires mobilization and plasma membrane trafficking of PAR2 from Golgi stores. We evaluated the contribution of […]
Functional and Structural Characterization of Bub3-BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The spindle assembly checkpoint (SAC) is an essential safeguarding mechanism devised to ensure equal chromosome distribution in daughter cells upon mitosis. The proteins Bub3 and BubR1 are key components of the mitotic checkpoint complex (MCC), an essential part of the molecular machinery on which the SAC relies. In the present work we have performed a […]
LOX and SNAI2 in cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Epithelial-to-mesenchymal transition (EMT) is important in cancer progression and metastasis. We and others have previously reported that lysyl oxidase (LOX) is overexpressed in aggressive cancers, is associated with increased mortality, and regulates EMT. However, the mechanism by which LOX mediates EMT is unknown. In this study, we investigated the effect of LOX on mediators […]
GIV as a recurrence marker in stage II colon cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Prognostic markers that identify patients with stage II colon cancers (CC) who are at risk of recurrence are essential to personalize therapy. We evaluated the potential of GIV/Girdin as a predictor of recurrence risk in such patients. Experimental Design: Expression of full-length GIV was evaluated by immunohistochemistry (IHC) using a newly developed monoclonal antibody […]
Targeting GRP78 in drug resistant myeloma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Glucose-regulated protein (GRP) 78 is overexpressed in multiple myeloma (MM) and both, its surface expression as well as its biological significance as key sensor of the unfolded protein response make GRP78 an ideal candidate for immunotherapeutic intervention. The monoclonal antibody PAT-SM6 targets surface (s) GRP78 and leads to disease stabilization when used as single-agent […]
Outcomes of patients with type I endoleak at completion of endovascular abdominal aneurysm repair
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Type I endoleak (TIE) during endovascular aneurysm repair (EVAR) is usually identified and treated intraoperatively. We evaluated the outcomes of patients who, despite possible treatment, had TIE at completion of EVAR. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RKUwnc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Comparison of supramesenteric aortic cross-clamping with supraceliac aortic cross-clamping for aortic reconstruction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Supraceliac aortic cross-clamping (SCXC) is routinely used during open aortic reconstruction (OAR) of pararenal aortic disease when suprarenal control is not feasible. On occasion, however, aortic control may be obtained at the supramesenteric level by supramesenteric cross-clamping (SMXC) between the superior mesenteric artery and the celiac axis. The purpose of this study was to compare […]
Comparison of a collagen plug arterial closure device with manual compression after endovascular interventions for peripheral artery disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Arterial closure devices (ACDs) seem to be safe and effective to obtain hemostasis for cardiac interventions and diagnostic vascular procedures. However, only limited evidence is presented on therapeutic interventions in patients with peripheral atherosclerotic disease. We compared ischemic and hemorrhagic complications of an ACD vs manual compression (MC) after puncture of the femoral artery for […]
Drivers of readmissions in vascular surgery patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Postoperative readmissions are frequent in vascular surgery patients, but it is not clear which factors are the main drivers of readmissions. Specifically, the relative contributions of patient comorbidities vs those of operative factors and postoperative complications are unknown. We sought to study the multiple potential drivers of readmission and to create a model for predicting […]
Temporary inferior vena cava filter indications, retrieval rates, and follow-up management at a multicenter tertiary care institution
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of this study was to investigate the practice pattern of inferior vena cava (IVC) filters and to determine factors predictive of filter retrievals at a multicenter, tertiary care institution. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RKUuvN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1SzE1ur via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ENT via xlomafota13 on Inoreader http://ift.tt/1SzE1ur via IFTTT
Developing a Registry for Thyroid Incidentalomas: Lessons Learned and the Path Forward
Thyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1onpJ5t via IFTTT
Effects of mild hypohydration on cooling during cold-water immersion following exertional hyperthermia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Purpose We investigated the effects of mild hypohydration compared to euhydration on the cooling efficacy of cold-water immersion (CWI). Methods Fourteen participants (eight male, six female; age 26 ± 5 years; ht 1.77 ± 0.08 m; wt 72.2 ± 8.8 kg; 20.6 ± 7.4 % body fat) completed one euhydrated (EU) trial followed by one hypohydrated trial (HY; via 24 h fluid restriction) in an environmental chamber (33.6 ± 0.9 °C, 55.8 ± 1.7 % RH). Volitional exercise was performed in a manner that matched end-exercise rectal temperature (*T* re) through repeating exercise mode and intens... περισσότερα »
The mind–muscle connection in resistance training: friend or foe?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract The results of Calatayud et al. (Eur J Appl Physiol, 2015. doi: 10.1007/s00421-015-3305-7) indicate that focusing on the pectoralis major and triceps brachii muscles during bench press exercise selectively enhanced their activation, and thus suggest a training strategy. However, the authors did not discuss the well-established negative effects that focusing on specific muscle groups has on exercise performance. For proper perspective of the results and their practical utility, it is helpful to note the interplay between negative and positive effects of different focus cond... περισσότερα »
Submaximal exercise intensity modulates acute post-exercise heart rate variability
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Purpose This study investigated whether short-term heart rate variability (HRV) can be used to differentiate between the immediate recovery periods following three different intensities of preceding exercise. Methods 12 males cycled for 8 min at three intensities: LOW (40–45 %), MOD (75–80 %) and HIGH (90–95 %) of heart rate (HR) reserve. HRV was assessed during exercise and throughout 10-min seated recovery. Results 1-min HR recovery was reduced following greater exercise intensities when expressed as R–R interval (RRI, ms) (*p* < 0.001), but not b min−1 (*p* = 0.217). ... περισσότερα »
Muscle focal vibration in healthy subjects: evaluation of the effects on upper limb motor performance measured using a robotic device
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Purpose Muscle vibration is a technique that applies a low-amplitude/high-frequency vibratory stimulus to a specific muscle using a mechanical device. The aim of this study was to evaluate, using robot-based outcomes, the effects of focal muscle vibration, at different frequencies, on the motor performance of the upper limb in healthy subjects. Methods Forty-eight volunteer healthy subjects (age: 31 ± 8 years) were enrolled. Subjects were assigned to three different groups: the first group, in which subjects underwent muscle vibration treatment with a frequency of 100 Hz;... περισσότερα »
Adipocytokine and ghrelin levels in relation to bone mineral density in prepubertal rhythmic gymnasts entering puberty: a 3-year follow-up study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Purpose To investigate changes in bone mineral density (BMD) in rhythmic gymnasts (RG) entering puberty and their age-matched untrained controls (UC) over the 36-month period, and associations with leptin, adiponectin and ghrelin over this period. Methods Whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD, WB bone mineral content (BMC), and leptin, adiponectin and ghrelin were measured in 35 RG and 33 UC girls at baseline and at 12-month intervals over the next 3 years. The change over the 36 months was calculated (∆ score). Results The pubertal development ov...περισσότερα »
Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Purpose While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling. Methods The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP...περισσότερα »
Mind–muscle connection revisited: do 100 studies about beanbag tossing, stick balancing, and dart throwing have any relevance for strength training?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
from Physiology via xlomafota13 on Inoreader http://ift.tt/1VUnCDT via IFTTT
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from squamous cell carcinoma via ok on Inoreader http://ift.tt/1SzE1ur via IFTTT
GSE71342 RNA binding protein TIA1 cytoplasmic expression as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (ESCC).
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Contributors* : Junichi Hamada ; Katsutoshi Shoda ; Kiyoshi Masuda ; Takuya Naruto ; Yuji Fujita ; Tomohiro Komoto ; Yuko Miyagami ; Yasusei Kudoh ; Daisuke Ichikawa ; Eigo Otsuji ; Issei Imoto *Series Type* : Other *Organism* : Homo sapiens T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein modulating many regulatory aspects of target mRNA metabolism. Despite several reports referring to the role of TIA1 in carcinogenesis, little is known about the significance of its expression and function in human cancers including esophageal squamous cell carcinoma (ESCC). In the ...περισσότερα »
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ENT via xlomafota13 on Inoreader http://ift.tt/1SzE1ur via IFTTT
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ENT via xlomafota13 on Inoreader http://ift.tt/1SzE1ur via IFTTT
Insights into the C-terminal Peptide Binding Specificity of the PDZ domain of neuronal Nitric Oxide Synthase. Characterization of the Interaction with the tight-junction protein Claudin-3 Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Neuronal Nitric Oxide synthase, unlike its endothelial and inducible counterparts, displays a PDZ (PSD-95/Dlg/ZO-1) domain located at its N-terminus involved in subcellular targeting. The C-termini of various cellular proteins insert within the binding groove of this PDZ domain and determine the subcellular distribution of nNOS. The molecular mechanisms underlying these interactions are poorly understood since […]
Extracellular vesicles isolated from brains of rTg4510 mice seed tau aggregation in a threshold-dependent manner Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The microtubule-associated protein tau has a critical role in Alzheimer’s disease and related tauopathies. There is accumulating evidence that tau aggregates spread and replicate in a prion-like manner, with the uptake of pathological tau seeds causing misfolding and aggregation of monomeric tau in recipient cells. Here, we focused on small extracellular vesicles enriched for exosomes, […]
Protein Kinase D and G{beta}{gamma} Mediate Agonist-Evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Agonist-evoked endocytosis of G protein-coupled receptors (GPCRs) has been extensively studied. The mechanisms by which agonists stimulate mobilization and plasma membrane translocation of GPCRs from intracellular stores are unexplored. Protease-activated receptor-2 (PAR2) traffics to lysosomes, and sustained protease signaling requires mobilization and plasma membrane trafficking of PAR2 from Golgi stores. We evaluated the contribution of […]
Functional and Structural Characterization of Bub3-BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The spindle assembly checkpoint (SAC) is an essential safeguarding mechanism devised to ensure equal chromosome distribution in daughter cells upon mitosis. The proteins Bub3 and BubR1 are key components of the mitotic checkpoint complex (MCC), an essential part of the molecular machinery on which the SAC relies. In the present work we have performed a […]
Developing a Registry for Thyroid Incidentalomas: Lessons Learned and the Path Forward
Thyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1onpJ5t via IFTTT
Developing a Registry for Thyroid Incidentalomas: Lessons Learned and the Path Forward
Thyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1onpJ5t via IFTTT
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
Publication date: Available online 30 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Eirini Zagkou, Thomas Aldridge, Peyman Alam, Peter A. Brennan We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ENT via xlomafota13 on Inoreader http://ift.tt/1RKUFXR via IFTTT
Endoskopische Revisionschirurgie des Nasenrückens
from #ENT via xlomafota13 on Inoreader http://ift.tt/1ZM6LDh via IFTTT
The Inflammatory Response in Psoriasis: a Comprehensive Review
Abstract Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. However, psoriasis is thought to result from a combination of genetic, epigenetic, and environmental influences. Recent studies have identified that epigenetic factors including dysregulated DNA methylation levels, abnormal histone modification and microRNAs expressions are involved in the development of psoriasis. The interplay of immune cells and cytokines is ...περισσότερα »
Spontaneous rupture of an internal laryngocele after neck dissection: a rare complication
Publication date: Available online 30 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Eirini Zagkou, Thomas Aldridge, Peyman Alam, Peter A. Brennan We present a rare, and to the best of our knowledge, previously unreported complication of the spontaneous rupture of an internal laryngocele after a routine neck dissection for metastatic squamous cell carcinoma. While this caused some diagnostic confusion, the patient was managed conservatively with no further complications. from #ENT via xlomafota13 on Inoreader http://ift.tt/1RKUFXR via IFTTT
LOX and SNAI2 in cancer
Purpose: Epithelial-to-mesenchymal transition (EMT) is important in cancer progression and metastasis. We and others have previously reported that lysyl oxidase (LOX) is overexpressed in aggressive cancers, is associated with increased mortality, and regulates EMT. However, the mechanism by which LOX mediates EMT is unknown. In this study, we investigated the effect of LOX on mediators of EMT. Experimental Design: We used chromatin immunoprecipitation and promoter-luciferase assays to determine the target gene of LOX. To determine the effects of SNAI2 in vivo, we used our metastat... περισσότερα »
Developing a Registry for Thyroid Incidentalomas: Lessons Learned and the Path Forward
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/1onpJ5t via IFTTT
Transfusion Medicine
Transfusion is essential for the care of a great number of individuals with Hematologic and Oncologic disorders; pediatric and adult patients alike often require red blood cell (RBC), platelet, plasma, or other blood component transfusions during their treatment courses. Because of the close relationship between Transfusion Medicine/Apheresis and Hematology/Oncology, it is imperative that clinicians in these arenas understand the advancements and challenges in each of their respective fields. Over the course of the past few decades, the investigative and clinical foci of Transfusi... περισσότερα »
Management of Thrombotic Microangiopathic Hemolytic Anemias with Therapeutic Plasma Exchange
Thrombotic microangiopathies are a heterogeneous group of inherited and acquired disorders sharing a common clinical presentation of microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. These disorders have been treated with plasma exchange (TPE) based on randomized controlled trials, which found this therapy to be effective in thrombotic thrombocytopenic purpura (TTP). For the remaining disorders, low- to very low-quality evidence exists for the use of TPE. When TPE is applied, the treatment regimen used for TTP is usually applied. There is a need for further ev...περισσότερα »
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Asthma and allergic rhinitis (AR) are common allergic comorbidities with a strong genetic component in which epigenetic mechanisms might be involved. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MCOIgC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Do Not Share Uncredited Artwork. Ever.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
If you contribute to a culture that keeps sharing stolen works, someday there isn’t going to be enough art to go around.
18 F-FDG PET/CT in the early prediction of pathological response in aggressive subtypes of breast cancer: review of the literature and recommendations for use in clinical trials
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Early assessment of response to neoadjuvant chemotherapy (NAC) might be helpful in avoiding the toxicity of ineffective chemotherapy and allowing refinement of treatment. We conducted a review of the literature regarding the applicability of 18F-FDG PET/CT to the prediction of an early pathological response in different subgroups of breast cancer. Clinical research in this […]
Richard P. Baum (ed): Therapeutic Nuclear Medicine. Springer Verlag Berlin Heidelberg, 2014, ISBN: 978-3-540-36719-2
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SnTFGA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Li-Jen Wang (ed): Key Diagnostic Features in Uroradiology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UDD48k via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Metabolic-structural concordance in paraneoplastic limbic encephalitis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SnTDi3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
FDG uptake at the bronchial stump after curative lobectomy for non-small cell lung cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Purpose Focal areas of FDG uptake may occur at the bronchial stump following curative lobectomy for non-small-cell lung carcinoma (NSCLC), even in the absence of suspicious CT changes. The purpose of our study was to investigate the significance of such PET/CT findings. Methods FDG-PET/CT scans performed in 54 patients after lobectomy for NSCLC were […]
Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SnTD1t via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
L. Mansi, E. Lopci, V. Cuccurullo and A. Chiti (eds): Clinical Nuclear Medicine in Pediatrics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UDD3kO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cancer theranostics with 64 Cu/ 177 Lu-loaded liposomes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SnTCdT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis
Asthma and allergic rhinitis (AR) are common allergic comorbidities with a strong genetic component in which epigenetic mechanisms might be involved. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MCOIgC via IFTTT
Müller glia provide essential tensile strength to the developing retina
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The Journal of Cell Biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1q460t6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
VP-shunt dysfunction caused by malaria CNS infection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Introduction Malaria is a widespread mosquito-borne infectious disease with over 300 million cases and roughly 900 thousand deaths in 2013. Cerebral involvement of malaria causes 50 % of all infection-associated deaths, especially in children below the age of 5 years. Hydrocephalus is a medical condition with abnormal accumulation of cerebrospinal fluid in physiological cavities […]
