Cancer Experts Endorse CDC's HPV Vaccine Guidelines
[image: hd62010.jpg] TUESDAY, July 19, 2016 -- The American Cancer Society has endorsed the U.S. government's HPV vaccination recommendations, which include immunizing all preteens against the sexually transmitted human papilloma virus. In a new report, the cancer... from Uncategorized via xlomafota13 on Inoreader http://ift.tt/2aeHxhH via IFTTT
Teachers, communities stand up for kids' health
[image: Protest] Air blaster. Aerial spraying. Fumigation. Unless things change, another school year will go by with pesticides being applied by these methods right outside classroom windows. That's why we hand-delivered boxes carrying over 26,000 comments demanding protections for schoolkids last Tuesday, as a crowd gathered outside the California Environmental Protection Agency and its Department of Pesticide Regulation (DPR). With "back-to-school" just around the corner, frustrated teachers, parents, grandparents and students pressed state officials to limit the use of volatile... περισσότερα »
Synthesis of vibroarthrographic signals in knee osteoarthritis diagnosis training
Vibroarthrographic (VAG) signals are used as useful indicators of knee osteoarthritis (OA) status. The objective was to build a template database of knee crepitus sounds. Internships can practice in the templa... http://ift.tt/29Kjczt
RNA expression of TLR10 in normal equine tissues
Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. http://ift.tt/29LMFW9
Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia
Streptococcus agalactiae (group B Streptococcus, GBS) is the most frequent pathogen isolated from neonates with invasive bacterial disease and responsible for serious infections in new... http://ift.tt/29KjoP9
Examining uptake of online education on obstructive sleep apnoea in general practitioners: a randomised trial
Obstructive sleep apnoea (OSA) affects up to 28 % of the adult population in Western countries. The detection and management of OSA by general practitioners (GPs) can be poor. The study aimed to examine what i... http://ift.tt/29LNmyy
Fracking Linked to Asthma Flare-ups
Researchers found significant levels of asthma attacks over 8 years in Pennsylvania counties that had unconventional natural gas development. Those closest to the wells had up to 4 times the risk. *Medscape Medical News* from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29SNhZ4 via IFTTT
ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12
The American Cancer Society has endorsed CDC guidelines for HPV vaccinations that recommend girls and boys ages 11 to 12 should receive the vaccine. *Medscape Medical News* from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29YKocU via IFTTT
Synthesis of vibroarthrographic signals in knee osteoarthritis diagnosis training
Vibroarthrographic (VAG) signals are used as useful indicators of knee osteoarthritis (OA) status. The objective was to build a template database of knee crepitus sounds. Internships can practice in the templa... from Medicine via xlomafota13 on Inoreader http://ift.tt/29Kjczt via IFTTT
RNA expression of TLR10 in normal equine tissues
Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. from Medicine via xlomafota13 on Inoreader http://ift.tt/29LMFW9 via IFTTT
Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia
Streptococcus agalactiae (group B Streptococcus, GBS) is the most frequent pathogen isolated from neonates with invasive bacterial disease and responsible for serious infections in new... from Medicine via xlomafota13 on Inoreader http://ift.tt/29KjoP9 via IFTTT
Examining uptake of online education on obstructive sleep apnoea in general practitioners: a randomised trial
Obstructive sleep apnoea (OSA) affects up to 28 % of the adult population in Western countries. The detection and management of OSA by general practitioners (GPs) can be poor. The study aimed to examine what i... from Medicine via xlomafota13 on Inoreader http://ift.tt/29LNmyy via IFTTT
Many skin cancer patients still too likely to sunburn
A recent study concludes that a substantial number of people with a history of the most frequent kind of nonmelanoma skin cancers still get sunburned at the same rate as those without previous history, probably because they are not using sun-protective methods the right way or in the right amounts. http://ift.tt/29MCKie
Size matters: Advance could increase sensitivity of liquid biopsies
A new study reports an advance that could increase the accuracy of liquid biopsies. The blood test monitors cancer progression by detecting pieces of circulating tumor DNA, but results can be obscured by abundant DNA from healthy cells. The research shows that the two types of DNA fragments are typically differently sized in cancer patients, a property that can be exploited to enhance the test's sensitivity. http://ift.tt/29S0PpG
Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database
To study risk for cardiovascular disease (CVD) in Japanese patients with rheumatoid arthritis (RA). http://ift.tt/29TsbNi
Anaphylactoid purpura triggered by cellulitis as a favorable prognosis: case report and literature review
An anaphylactoid purpura affects small capillaries in the skin and other organs. Although two cases of anaphylactoid purpura exacerbated by cellulitis have been reported in Japanese literatures, its prognosis ... http://ift.tt/2arRAwl
Duplication of the right vertebral artery: MRA findings and review of the literature
Duplication of the vertebral artery (VA) is a rare vascular variant. To the best our knowledge, only fourteen cases have been reported with angiographic findings that they have dual origin of the VA from ipsil... http://ift.tt/29Tt0Wx
Cross-cultural adaptation and validation of the Chinese version of Toronto Extremity Salvage Score for patients with extremity sarcoma
As a widely used instrument for patients with extremity sarcoma, the Toronto Extremity Salvage Score (TESS) has never been cross-culturally adapted for Chinese population. The objective of our study was to inv... http://ift.tt/2arQYqi
Expression of a mitochondrial gene orfH79 from CMS-Honglian rice inhibits Escherichia coli growth via deficient oxygen consumption
Cytoplasmic male sterility (CMS) has often been associated with abnormal mitochondrial open frames (ORF), orfH79 is a mitochondrial chimeric gene responsible for the CMS trait in Honglian (HL) rice. In this study... http://ift.tt/29Tt0G1
Risk for cardiovascular disease in Japanese patients with rheumatoid arthritis: a large-scale epidemiological study using a healthcare database
To study risk for cardiovascular disease (CVD) in Japanese patients with rheumatoid arthritis (RA). from Medicine via xlomafota13 on Inoreader http://ift.tt/29TsbNi via IFTTT
Anaphylactoid purpura triggered by cellulitis as a favorable prognosis: case report and literature review
An anaphylactoid purpura affects small capillaries in the skin and other organs. Although two cases of anaphylactoid purpura exacerbated by cellulitis have been reported in Japanese literatures, its prognosis ... from Medicine via xlomafota13 on Inoreader http://ift.tt/2arRAwl via IFTTT
Duplication of the right vertebral artery: MRA findings and review of the literature
Duplication of the vertebral artery (VA) is a rare vascular variant. To the best our knowledge, only fourteen cases have been reported with angiographic findings that they have dual origin of the VA from ipsil... from Medicine via xlomafota13 on Inoreader http://ift.tt/29Tt0Wx via IFTTT
Cross-cultural adaptation and validation of the Chinese version of Toronto Extremity Salvage Score for patients with extremity sarcoma
As a widely used instrument for patients with extremity sarcoma, the Toronto Extremity Salvage Score (TESS) has never been cross-culturally adapted for Chinese population. The objective of our study was to inv... from Medicine via xlomafota13 on Inoreader http://ift.tt/2arQYqi via IFTTT
Expression of a mitochondrial gene orfH79 from CMS-Honglian rice inhibits Escherichia coli growth via deficient oxygen consumption
Cytoplasmic male sterility (CMS) has often been associated with abnormal mitochondrial open frames (ORF), orfH79 is a mitochondrial chimeric gene responsible for the CMS trait in Honglian (HL) rice. In this study... from Medicine via xlomafota13 on Inoreader http://ift.tt/29Tt0G1 via IFTTT
Erratum to: Morphometrical analysis of transbronchial cryobiopsies
from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29S5RGz via IFTTT
Medication Adherence in Patients with Bipolar Disorder: A Comprehensive Review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Abstract Poor medication adherence is a pervasive problem that causes disability and suffering as well as extensive financial costs among individuals with bipolar disorder (BD). Barriers to adherence are numerous and cross multiple levels, including factors related to bipolar pathology and those unique to an individual’s circumstances. External factors, including treatment setting, healthcare system, and […]
Dry eye
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Dry eye: A deficiency of tears. The main symptom is usually a scratchy or sandy feeling as if something is in the eye. Other symptoms may include stinging or burning of the eye; episodes of excess tearing that follow periods of very dry sensation; a stringy discharge from the eye; and pain and redness of […]
Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Summary This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core […]
Overestimating the role of environment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
In a recent article, Wu et al. (Nature 2016;529:43-47) review previous studies and present new estimates for the contribution of extrinsic factors to cancer development. The new estimates are generally close to 100%, even for bone and brain cancers that have no known associations with lifestyle and are typically not considered to be preventable. We […]
Simulation study to determine the impact of different design features on design efficiency in discrete choice experiments
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Objectives Discrete choice experiments (DCEs) are routinely used to elicit patient preferences to improve health outcomes and healthcare services. While many fractional factorial designs can be created, some are more statistically optimal than others. The objective of this simulation study was to investigate how varying the number of (1) attributes, (2) levels within attributes, (3) […]
Evaluation of a heat warning system in Adelaide, South Australia, using case-series analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Background Heatwave warning systems aim to assist in reducing health effects during extreme heat. Evaluations of such systems have been limited. This study explored the effect of a heatwave warning programme on morbidity and mortality in Adelaide, South Australia, by comparing extreme events in 2009 and 2014, the latter with exposure to the preventive programme. […]
Person-centred rehabilitation: what exactly does it mean? Protocol for a scoping review with thematic analysis towards framing the concept and practice of person-centred rehabilitation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Introduction Person-centredness is a philosophy for organising and delivering healthcare based on patients’ needs, preferences and experiences. Although widely endorsed, the concept suffers from a lack of detail and clarification, in turn accounting for ambiguous implementation and outcomes. While a conceptual framework based on a systematic review defines person/patient-centred care components (Scholl et al, 2014), […]
European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer’s disease–the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Introduction In conjunction with the NILVAD trial, a European Multicentre Double-Blind Placebo Controlled trial of Nilvadipine in Mild-to-Moderate Alzheimer’s disease (AD), there are four NILVAD substudies in which eligible NILVAD patients are also invited to participate. The main NILVAD protocol was previously published in BMJ Open (2014). The objectives of the NILVAD substudies are to […]
Sugar-sweetened beverages coverage in the British media: an analysis of public health advocacy versus pro-industry messaging
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Objectives To assess the extent of media-based public health advocacy versus pro-industry messaging regarding sugar-sweetened beverages (SSBs). Design We conducted a systematic analysis to identify and examine all articles regarding SSBs published in all mainstream British print newspapers and their online news websites from 1 January 2014 to 31 December 2014. We initially conducted a […]
Job satisfaction and associated factors among healthcare staff: a cross-sectional study in Guangdong Province, China
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Objectives This cross-sectional study aimed to explore job satisfaction among healthcare staff in Guangdong following the health system reforms in 2009, and to investigate the association between job satisfaction and work stress, work–family conflict and doctor–patient relationship. Design Cross-sectional survey. Setting The Fifth National Health Service Survey was carried out in Guangdong, China. Participants All […]
The Impact of Financial Conflicts of Interest in Plastic Surgery: Are They All Created Equal?
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Background: Recently, several studies have demonstrated that articles that disclose conflicts of interests (COI) are associated with publication of positive results. The purpose of this study was to learn more about the different types of COI as they relate to the general topic of COI in plastic surgery. Specifically, we aimed to examine whether different types of COI are more likely than others to be associated with the presentation of positive findings. Methods: We reviewed all original articles in Annals of Plastic Surgery, Journal of Plastic, Reconstructive, and Ae... περισσότερα »
Corrigendum to “Identifying predictive factors for long-term complications following button battery impactions: A case series and literature review” [Int. J. Pediatr. Otorhinolaryngol. (2016) 198–202]
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
The authors have made the following amendments to their manuscript. http://ift.tt/29N0m6D
Laryngeal Squamous Cell Carcinoma Quality Metrics
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
This cohort study examines whether compliance with proposed quality metrics is associated with improved survival in patients with laryngeal squamous cell carcinoma treated with surgery with or without adjuvant therapy. http://ift.tt/2a7iwT2
Apocrine Hidrocystoma: A Rare Case Report
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Abstract Hidrocystoma is a cystic tumor originating from a dilated sweat gland. The tumor is typically small and located predominantly on the face, particularly in the eyelid margins. They are two classical types of hidrocystomas i.e., Apocrine and Eccrine. Apocrine hidrocystomas are cystic lesions that arise from the apocrine secretory coil and Eccrine hidrocystomas represent retention cysts of the eccrine duct. Multiple apocrine hidrocystomas confined to the eyelids have been recognized as a feature of a new variant of ectodermal dysplasia. Here we present a rare case of Apocrin... περισσότερα »
Management of obstructive sleep apnea in children: A practical approach
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Kevin D. Pereira, MD; Cindy K. Jon, MD, MPH; Peter Szmuk, MD; Rande H. Lazar, MD; Ron B. Mitchell, MD Abstract The management of sleep disordered breathing (SDB) in children differs between institutions, and there is a need for an updated review of current practice. Literature was reviewed using the PubMed database from 1995 to 2015 by four tertiary care providers experienced in the management of children with SDB. Articles were selected for clinical applicability, strength of evidence, and practicality for practicing clinicians. Fifty-five articles were identified by tertiary car... περισσότερα »
Comparison of a microsliced modified chondroperichondrium shield graft and a temporalis fascia graft in primary type I tympanoplasty: A prospective randomized controlled trial
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Shambhu Nath Bhattacharya, MS; Sudipta Pal, MS; Somnath Saha, MS; Prasanta Kumar Gure, MS; Anupam Roy, MS Abstract We conducted a prospective, randomized, controlled trial to compare outcomes in type I tympanoplasty patients who received an autologous microsliced modified cartilage perichondrium shield graft (cartilage group) and those who received an autologous temporalis muscle fascia graft (fascia group). Our three outcomes measures were (1) anatomic success rates at 3 months, (2) hearing results at 6 months, and (3) rates of morphologic success (i.e., the absence of reperforat... περισσότερα »
Accessory parotid gland tumors: A series of 4 cases
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Takuya Kakuki, MD; Kenichi Takano, MD; Makoto Kurose, MD; Atsushi Kondo, MD; Tsuyoshi Okuni, MD; Noriko Ogasawara, MD; Tetsuo Himi, MD Abstract Accessory parotid gland tumors are clinically rare, and their management remains unclear. In this article, we describe our experience with 4 patients-2 males and 2 females, aged 13 to 66 years-who were diagnosed with an accessory parotid gland tumor. All patients presented with an asymptomatic midcheek swelling, and all underwent fine-needle aspiration biopsy, ultrasonography, computed tomography, and magnetic resonance imaging. A standard... περισσότερα »
Neuroendocrine tumors of the larynx
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Lester D. Thompson, MD *The most common laryngeal neuroendocrine tumor is the atypical carcinoid (moderately differentiated neuroendocrine carcinoma), which is a malignant epithelial tumor showing neuroendocrine histologic and immunohistochemical features.* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may also like to:* - Sign Up For The Free eNewsletter http://ift.tt/29TB0UN
Ketamine-snorting-induced nasal septum perforation
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Keng-Kuang Tsai, MD; Chih-Hung Wang, MD, PhD *Ketamine causes vasoconstriction, and long-term abuse leads to mucosal ischemia, atrophy and, ultimately, necrosis, followed by underlying cartilage or bone destruction.* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may also like to:* - Sign Up For The Free eNewsletter http://ift.tt/29WXlVg
Phonatory symptoms and impact on quality of life in female patients with goiter
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Abdul-latif Hamdan, MD, MPH, FACS; Alexander Dowli, MD; Jad Jabbour, BS; Alain Sabri, MD; Sami T. Azar, MD, FACP Abstract Our objective is to report on the prevalence of phonatory symptoms and impact on quality of life in a group of female patients with goiter who had not been selected for surgery or who had not presented to the emergency room with respiratory distress. A total of 40 patients with goiter and 14 controls were enrolled in this study. Demographic data included age, sex, laryngopharyngeal reflux disease, allergy, smoking, duration of disease, presence or absence of co... περισσότερα »
Lingual osseous choristoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Daniel T. Ginat, MD, MS; Louis Portugal, MD *When they occur, symptoms of lingual osseous choristomas may include globus sensation, dysphagia, gagging, nausea, and irritation.* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may also like to:* - Sign Up For The Free eNewsletter http://ift.tt/29WXqs6
Nonsurgical options to treat giant-cell tumors of the head and neck: A case report and brief review of the literature
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Allison N. Rasband-Lindquist, MD; Jonathan D. Lindquist, MD; Christopher G. Larsen, MD; Aaron Thiessen, MD; Douglas Girod, MD Abstract Central giant-cell granulomas (CGCGs) are relatively uncommon. When they do occur, they typically arise in the mandible and maxilla. Some lesions are more destructive than others, and the destructive subtype has a tendency to recur. Unfortunately, there is no reproducible way to differentiate aggressive from nonaggressive subtypes. Treatment of CGCG has historically been based on surgical curettage or wide local excision. However, surgery has been ... περισσότερα »
Laryngeal amyloidosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Karthik S. Shastri, MD; Amy L. Rutt, DO; Robert T. Sataloff, MD, DMA, FACS *The diagnosis of laryngeal amyloidosis should trigger evaluation for systemic amyloidosis.* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may also like to:* - Sign Up For The Free eNewsletter http://ift.tt/29WXGr9
Clinical characteristics and follow-up of patients with external ear canal cholesteatoma treated conservatively
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Erdal Sakalli, MD; Deniz Kaya, MD; Cengiz Celikyurt, MD; Selcuk Cem Erdurak, MD Abstract We conducted a retrospective study to evaluate the clinical properties and follow-up of patients with external ear canal cholesteatoma (EECC) who were treated conservatively. Our study group was made up of 15 patients-6 men and 9 women, aged 21 to 82 years (mean: 48). In addition to demographic data, we compiled information on presenting signs and symptoms, the location of the lesion, treatment, and follow-up. All EECCs occurred spontaneously, and all were limited to the temporal bone. Lesions... περισσότερα »
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI u... περισσότερα »
In Memoriam: John K. Niparko, MD, 1954 to 2016
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]No abstract available http://ift.tt/29JZDY5
Mary Gantz, 1949–2016, A Friend to So Many…
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]No abstract available http://ift.tt/29Ls7wY
An Unusual Complication of Stapes Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]No abstract available http://ift.tt/29JZZOj
Book Review
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
No abstract available http://ift.tt/29JZyDE
Cochlear Patency After Transmastoid Labyrinthectomy for Ménière's Syndrome
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Objective: Labyrinthectomy is considered the "gold standard" in the treatment of intractable vertigo attacks because of Ménière's Disease (MD) but sacrifices all residual hearing. Interest in auditory rehabilitation has lead to cochlear implantation in some patients. Concern remains that the cochlear lumen may fill with tissue or bone after surgery. This study sought to determine the incidence of obliteration of the cochlea after transmastoid labyrinthectomy. Study Design: Retrospective observational study. Setting: Tertiary referral center. Patients: Eighteen patients... περισσότερα »
Botulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus due to EPT by a systematic review of the literature. Methods: In accordance with PRISMA guideli... περισσότερα »
FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In Vitro But Does Not Alter Virulence in a Cholesteatomas Model
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Hypothesis: Bacterial biofilm formation within cholesteatomas is responsible for increased persistence and tissue destruction and Pseudomonas aeruginosa deficient in biofilm formation (PAO1 ΔfleQ) are less virulent than the parent bacteria. Background: Infected aural cholesteatomas have been demonstrated to be more destructive than uninfected cholesteatomas and infections are more persistent. The chronicity and persistence of infections within cholesteatomas may be because of the presence of biofilm formation. Methods: Twenty-seven mutant strains of PAO1 were screened ... περισσότερα »
A Systematic Review on Complications of Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Objective: To investigate skin-related postoperative complications from tissue preservation approaches in percutaneous bone conduction device (BCD) implantations. Data Sources: PubMed, Embase, and Cochrane Library. Study Selection: We identified studies on BCDs including the opted surgical technique and derived complications. Retrieved articles were screened using predefined inclusion criteria. Critical appraisal included directness of evidence and risk of bias. Studies that successfully passed critical appraisal were included. Data Extraction: Outcome measures include... περισσότερα »
Imaging Characteristics of Cerebellopontine Angle Chloroma
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]No abstract available http://ift.tt/29JZKmu
Type I Tympanoplasty Meta-Analysis: A Single Variable Analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: image]Objective: To determine which independent variables influence the efficacy of type I tympanoplasty in adult and pediatric populations. Data Sources: A search of the PubMed database and Cochrane Database of Systematic Reviews using the key words "tympanoplasty OR myringoplasty" from January 1966 to July 2014 was performed. Study Selection: Studies reporting outcomes of myringoplasty or Type I tympanoplasty in primary non-cholesteatomatous chronic tympanic membrane (TM) perforation were included. Data Extraction: Of 4,698 abstracts reviewed, 214 studies involving 26,097 ... περισσότερα »
Endobronchial Pagetoid Spread of a Breast Carcinoma Metastatic to the Lung: A Case Report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the time of diagnosis it was a T1N0, grade […]
Sternocleidomastoid innervation from an aberrant nerve arising from the hypoglossal nerve: a prospective study of 160 neck dissections
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Abstract Background Anatomical variants of the spinal root of the accessory nerve and cervical plexus are well known but other variants are exceptionally rare. Methods A prospective study of 160 selective neck dissections was undertaken following an index case, where a presumed C1 nerve (travelling with the hypoglossal nerve) was found to innervate sternocleidomastoid (SCM). […]
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/29TZsW9 via IFTTT
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/29TZsW9 via IFTTT
Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
The optimal timing and sequencing of thoracic radiotherapy and chemotherapy, which is the standard treatment of «limited-stage» small-cell lung cancer, has fuelled debate for many years. This individual patient data meta-analysis provides the best evidence of the beneficial effect of «earlier or shorter» radiotherapy when chemotherapy is administered with good compliance. from #ORL-AlexandrosSfakianakis via ola […]
Paclitaxel plus Bevacizumab or Paclitaxel as First-line Treatment for HER2-Negative Metastatic Breast Cancer in a Multicenter National Observational Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
In the large-scale, real-life multicenter Unicancer-ESME database, OS adjusted for major prognostic factors was longer in first line metastatic breast cancer patients receiving paclitaxel and bevacizumab as compared to those receiving paclitaxel alone (HR 0.672, 95%CI 0.601-0.752; median survival time 27.7 versus 19.8 months). Despite robust methodology, real-life data are exposed to important potential biases […]
Prognostic role of tumor PIK3CAmutation in colorectal cancer: a systematic review and meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
This study has the largest sample size of over 12000, and is also the most comprehensive assessment of the literature to date regarding prognostic role of tumour PIK3CA mutation in colorectal cancer (CRC). We find that in patients with CRC, PIK3CA mutation may not add prognostic information regarding overall survival (OS) or progression-free survival (PFS). […]
PD-L1 expression in penile cancer: A new frontier for immune checkpoint inhibitors?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/29TiKdy via IFTTT
The Efficacy of CIK-Based Immunotherapies for Advanced Solid Tumors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Objective: To investigate the efficacy of cytokine-induced killer cell-based immunotherapies in patients with advanced malignant solid tumors and the difference in clinical efficiency among 3 kinds of cytokine-induced killer cell-based immunotherapies. Methods: One hundred forty-six cases with advanced solid tumor, 230 cycles of cytokine-induced killer cell-based immunotherapies, were involved in this study. T-lymphocyte subsets, carcinoembryonic […]
Application of Quantitative Autofluorescence Bronchoscopy Image Analysis Method in Identifying Bronchopulmonary Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Autofluorescence bronchoscopy shows good sensitivity and poor specificity in detecting dysplasia and cancer of the bronchus. Through quantitative analysis on the target area of autofluorescence bronchoscopy image, determine the optimal identification index and reference value for identifying different types of diseases and explore the value of autofluorescence bronchoscopy in diagnosis of lung cancer. Patients with […]
Pathogenesis of Rhinitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Pathogenesis of Rhinitis: Summary Rhinitis is a heterogeneous condition that has been associated with inflammatory responses as in allergic rhinitis but can also occur in the absence of inflammation such as in so-called ‘idiopathic’ (previously ‘vasomotor’) rhinitis. Allergic rhinitis affects approximately 1 in 4 of the population of westernised countries and is characterized by typical […]
Laryngological presentations of Ehlers-Danlos syndrome
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
: case series of nine patients from two London tertiary referral centers: 1.This is a first-in-literature case series of 9 patients with Ehlers-Danlos syndrome (EDS) presenting with laryngological manifestations of their condition. 2.Laryngological and upper digestive tract complaints are relatively common and very varied in EDS, and in this series included dysphagia, dysphonia, laryngospasm, chronic […]
Smell preservation following endoscopic unilateral resection of esthesioneuroblastoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
: a multi-institutional experience: Background The gold standard of treatment for esthesioneuroblastoma consists of en bloc craniofacial resection with postoperative therapy dictated by histology and tumor extent. Numerous studies have shown fully endoscopic approaches to provide comparable survival and recurrence rates with decreased patient morbidity. Here we report the first multi-institutional series assessing smell outcomes […]
Anesthesia-airway management in a newborn with syngnathia
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
We presented anesthesia and airway management in a newborn with syngnathia. Surgical correction of the syngnathia was planned by the department of plastic surgery in a newborn weighing 3400 g. Preoperatively, the patient was in good status, was active, and had pinkish skin color. In addition to mucosal adhesions in the upper and lower gingivae on the right side, a full-layer adhesion was present on the left side in both upper and lower gingivae that also involved the bony structures (Fig. 1). Other physical examination and laboratory results were within the reference range for age.... περισσότερα »
Difficult mask ventilation: simple step to make the impossible, possible!
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Mask ventilation is one of the most important skills in airway management. Difficulty in mask ventilation can become life threatening if it is associated with difficulty in intubation during general anesthesia. We report a potential impossible ventilation condition which was safely and easily overcome with appropriate innovative modification of an Opsite adhesive film. http://ift.tt/29TrsIy
Spinal Cord Ischaemia after Complex Aortic Procedures
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Publication date: Available online 18 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): M.J.H.M. Jacobs, G.W.H. Schurink, B.M.E. Mees http://ift.tt/2a7PGlw
Rapid Time to Positivity of Cerebrospinal Fluid Culture with Coagulase-Negative Staphylococcus Is More Likely to Reflect a True Infection Than Contamination
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Rong Da, Youwei Wu, Wanjing Liu, Hong Shi, Wei Wang ObjectiveCerebrospinal fluid (CSF) culture is the gold standard for diagnosing postoperative central nervous system infection. The time to positivity (TTP) of an automated continuous blood culture system may indicate the original concentration of the organism. Coagulase-negative Staphylococcus (CoNS), the common organism recovered in CSF, poses difficulty in differentiating infection from contamination. This study investigated ... περισσότερα »
Movement preparation and execution: differential functional activation patterns after traumatic brain injury
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Years following the insult, patients with traumatic brain injury often experience persistent motor control problems, including bimanual coordination deficits. Previous studies revealed that such deficits are related to brain structural white and grey matter abnormalities. Here, we assessed, for the first time, cerebral functional activation patterns during bimanual movement preparation and performance in patients with traumatic brain injury, using functional magnetic resonance imaging. Eighteen patients with moderate-to-severe traumatic brain injury (10 females; aged 26.3 years, s... περισσότερα »
Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Multiple sclerosis is among the most common causes of neurological disability in young adults. Here we provide the preclinical proof of concept of the benefit of a novel strategy of treatment for multiple sclerosis targeting neuroendothelial *N*-methyl-D-aspartate glutamate receptors. We designed a monoclonal antibody against *N*-methyl-D-aspartate receptors, which targets a regulatory site of the GluN1 subunit of *N*-methyl-D-aspartate receptor sensitive to the protease tissue plasminogen activator. This antibody reverted the effect of tissue plasminogen activator on *N*-methyl-D-... περισσότερα »
Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
*SYNJ1* encodes a polyphosphoinositide phosphatase, synaptojanin 1, which contains two consecutive phosphatase domains and plays a prominent role in synaptic vesicle dynamics. Autosomal recessive inherited variants in *SYNJ1* have previously been associated with two different neurological diseases: a recurrent homozygous missense variant (p.Arg258Gln) that abolishes Sac1 phosphatase activity was identified in three independent families with early onset parkinsonism, whereas a homozygous nonsense variant (p.Arg136*) causing a severe decrease of mRNA transcript was found in a single ... περισσότερα »
Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Summary This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated *a priori* to ensure repre... περισσότερα »
Response by Kim and Ha to Letter Regarding Article, "Clinical Significance of Fluid-Attenuated Inversion Recovery Vascular Hyperintensities in Borderzone Infarcts" [Letter to the Editor]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: crossmark_button.png] http://ift.tt/29SJQrh
Letter by Tian and Lou Regarding Article, "Clinical Significance of Fluid-Attenuated Inversion Recovery Vascular Hyperintensities in Borderzone Infarcts" [Letter to the Editor]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: crossmark_button.png] http://ift.tt/29SJLUH
Anesthesia-airway management in a newborn with syngnathia
We presented anesthesia and airway management in a newborn with syngnathia. Surgical correction of the syngnathia was planned by the department of plastic surgery in a newborn weighing 3400 g. Preoperatively, the patient was in good status, was active, and had pinkish skin color. In addition to mucosal adhesions in the upper and lower gingivae on the right side, a full-layer adhesion was present on the left side in both upper and lower gingivae that also involved the bony structures (Fig. 1). Other physical examination and laboratory results were within the reference range for age.... περισσότερα »
Difficult mask ventilation: simple step to make the impossible, possible!
Mask ventilation is one of the most important skills in airway management. Difficulty in mask ventilation can become life threatening if it is associated with difficulty in intubation during general anesthesia. We report a potential impossible ventilation condition which was safely and easily overcome with appropriate innovative modification of an Opsite adhesive film. from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/29TrsIy
Serpentine adaptation with gene flow in A. arenosa Plant Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary genomic approach coupled with elemental profiling to assess… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis […]
Easily recognizable sonographic patterns of ductal carcinoma in situ of the breast
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Ductal carcinoma in situ (DCIS) is a malignant proliferation of ductal epithelium confined by the basement membrane of the involved breast ducts. The aim of this study was to categorize positive findings of DCIS of the breast on sonography. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29XojfB via IFTTT
Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Chemoradiotherapy (CRT) has become the mainstay of treatment for tonsillar squamous cell carcinoma (SCC). Pre-CRT tonsillectomy is frequently performed, mostly for small primary tumors (T1-T2). However, the benefits of pre-CRT tonsillectomy remain unclear. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29SF5y6 via IFTTT
Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract Bacterial infections are still one of the main causes of patient morbidity and mortality worldwide. Nowadays, many imaging techniques, like computed tomography or magnetic resonance imaging, are used to identify inflammatory processes, but, although they recognize anatomical modifications, they cannot easily distinguish bacterial infective foci from non bacterial infections. In nuclear medicine, many efforts […]
Different segments of the cerebral vasculature reveal specific endothelial specifications, while tight junction proteins appear equally distributed
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract The identification of the “paucity of transportation vesicles” and “belt-like” tight junctions (TJs) of endothelial cells as the “morphological correlate of a blood–brain barrier” (BBB) by Reese and Karnovsky (J Cell Biol 34:207–217, 1967) has become textbook knowledge, and countless studies have helped to further define the elements, functions, and dynamics of the BBB. […]
gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
• Met amplification and protein hyperactivation is a resistance mechanism to both 1st and 3rd generation EGFR inhibitors• Met inhibition effectively overcomes the resistance to 3rd generation EGFR inhibitors both in vitro and in vivo, including enhancement of apoptosis or G1 cell cycle arrest.• Enhanced Bim stabilization is a critical mechanism that mediates augmented induction […]
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
• ASCT2 is physically associated with EGFR in a molecular complex• Cetuximab downregulates ASCT2 via cetuximab-mediated EGFR endocytosis• Co-targeting ASCT2 by cetuximab sensitizes HNSCC cells to ROS-induced apoptosis• Cetuximab sensitizes ROS-induced apoptosis independently of EGFR kinase inhibition from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29Xo7g3 via IFTTT
Determinants of resistance to chemotherapy and radiation in breast cancer stem cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
• Determinants of anti-oncogenic treatment resistance in breast cancer stem cells• Mechanisms underlying stemness, chemo/radioresistance in breast cancer stem cells• Gene/gene products implicated in chemo/radioresistance in breast cancer stem cells• Potential functional associations among genes/gene products from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29U1UvM via IFTTT
Fewer allergies: A possible upside of thumb sucking and nail biting
Follow me on Twitter @drClaire As a pediatrician, I get a lot of questions about thumb sucking and nail biting. Both worry parents a lot: they worry about damage to teeth, about infections, and about teasing from other children. Now a study published in the journal Pediatrics, the official journal of the American Academy of… Continue reading Fewer allergies: A possible upside of thumb sucking and nail biting
Steroid-responsive headache in scleroderma en coup de sabre
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29KQeQ2 via IFTTT
Neti Pot Beats Steam for Sinus Congestion Relief
Rinsing nasal passages with saline solution may improve symptoms, study saysSource: HealthDay Related MedlinePlus Pages: Allergy, Common Cold, Sinusitis (Source: MedlinePlus Health News) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2asLD1T via IFTTT
Prospecting TCRs for immunotherapy
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3529 Author: Zoltan Fehervari (Source: Nature Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29MktCE via IFTTT
Self-Expansion is Associated with Better Adherence and Obesity Treatment Outcomes in Adults
Abstract Background Previous studies have shown that self-expansion (e.g., increasing positive self-content via engaging in novel, rewarding activities) is associated with smoking cessation and attenuated cigarette-cue reactivity. Purpose This study examined whether self-expansion is associated with better adherence, weight loss, and physical activity (PA) outcomes within a weight loss intervention. Methods Participants from Shape Up… Continue reading Self-Expansion is Associated with Better Adherence and Obesity Treatment Outcomes in Adults
Interleukin 1α and the inflammatory process
Nature Immunology 17, 906 (2016). doi:10.1038/ni.3503 Authors: Nelson C Di Paolo & Dmitry M Shayakhmetov (Source: Nature Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29KPQ4b via IFTTT
Fracking Linked to Asthma Flare-upsFracking Linked to Asthma Flare-ups
Researchers found significant levels of asthma attacks over 8 years in Pennsylvania counties that had unconventional natural gas development. Those closest to the wells had up to 4 times the risk. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29UfDFp via IFTTT
Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
Nature Immunology 17, 1005 (2016). doi:10.1038/ni0816-1005c Author: Jonathan S Silver, Jennifer Kearley, Alan M Copenhaver, Caroline Sanden, Michiko Mori, Li Yu, Gretchen Harms Pritchard, Aaron A Berlin, Christopher A Hunter, Russell Bowler, Jonas S Erjefalt, Roland Kolbeck & Alison A Humbles (Source: Nature Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29MkhDo via IFTTT
ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12ACS Recommends HPV Vaccine for Girls and Boys Ages 11-12
The American Cancer Society has endorsed CDC guidelines for HPV vaccinations that recommend girls and boys ages 11 to 12 should receive the vaccine. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2asM0ts via IFTTT
Dengue suppresses MAVS
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3527 Author: Laurie A Dempsey (Source: Nature Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29KQ6jr via IFTTT
Presentation to Emergency Departments for Acute Rhinosinusitis: Disparities in Symptoms by Race and Insurance Status
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Objective Medicaid and self-pay insurance statuses and race are associated with emergency department (ED) presentation for uncomplicated acute rhinosinusitis (ARS). We investigated whether ARS symptomatology could explain this disproportionate ED use. Study Design 2006-2010 National Hospital Ambulatory Medical Care Surveys. Setting EDs in the United States. Subjects and Methods The data comprise 1,632,826 adult visits for uncomplicated ARS at hospital EDs. Patient-reported reasons for presentation included constitutional symptoms, facial pain or headache, sinonasal symptoms, head c... περισσότερα »
Pretreatment Neutrophil-Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Objective To assess pretreatment levels in the counts and percentages of leukocytes and the neutrophil-lymphocyte ratio (NLR) in benign and malignant salivary gland tumors (SGTs) while investigating whether NLR is an inflammatory marker for distinguishing low- from high-grade parotid gland tumors. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods This study was performed on 182 patients with SGTs (age range: 16-87 years; 93 male and 89 female) who were treated between January 2010 and May 2015. Pretreatment counts and percentages of ... περισσότερα »
Current concepts in salvage procedures for failing microvascular flaps: is there a superior technique? Insights from a systematic review of the literature
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Microvascular free tissue transfer is a routine procedure with high predictability and a low complication rate. However, compromised flap perfusion remains a challenge and there is no consensus regarding the appropriate flap salvage protocol. The purpose of this study was to identify techniques with implications for flap salvage procedures and to assess their efficacy. A systematic review of studies published in the literature between 1990 and 2015, with predefined inclusion and exclusion criteria, was performed. http://ift.tt/29Nf25w
Sleep architecture in Pierre-Robin sequence: The effect of mandibular distraction osteogenesis
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Pierre-Robin Sequence (PRS), a triad of micro/retrognathia, glossoptosis, and upper airway obstruction, usually in conjunction with a cleft palate is frequently associated with significant morbidity. Mandibular distraction osteogenesis (MDO) is an effective treatment modality to address retroglossal upper airway obstruction by increasing the anterior-posterior diameter of the infant airway. Although MDO has been shown to improve the apnea-hypopnea index (AHI) in children with PRS, the consequences of MDO on other aspects of infant sleep, including hypercapnea, hypoxia, the REM to ... περισσότερα »
Tonsillectomies and Respiratory Complications in Children: A Look at Pre-op Polysomnography Risk Factors and Post-op Admissions
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
To identify predictors of post-operative respiratory complications in children undergoing tonsillectomy. http://ift.tt/29KDjxH
The Association of Residential Mold Exposure and Adenotonsillar Hypertrophy in Children Living in Damp Environments
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
There are many consequences of mold exposure related to respiratory system health of children This retrospective cohort study aims to find the association between adenoid hypertrophy and mold exposure in children living in damp environments. http://ift.tt/29KD1Xj
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
Related Articles *Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.* F1000Res. 2016;5:1005 Authors: Watson AJ, Hopkins GV, Hitchin S, Begum H, Jones S, Jordan A, Holt S, March HN, Newton R, Small H, Stowell A, Waddell ID, Waszkowycz B, Ogilvie DJ Abstract RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of o... περισσότερα »
Evaluation and Management of Chemotherapy-Induced Epiphora, Punctal and Canalicular Stenosis, and Nasolacrimal Duct Obstruction.
Related Articles *Evaluation and Management of Chemotherapy-Induced Epiphora, Punctal and Canalicular Stenosis, and Nasolacrimal Duct Obstruction.* Ophthal Plast Reconstr Surg. 2016 Jul 13; Authors: Mansur C, Pfeiffer ML, Esmaeli B Abstract PURPOSE: To describe the frequency, mechanisms, and treatment of epiphora caused by chemotherapeutic agents. METHODS: Review of relevant articles published in PubMed. RESULTS: The chemotherapeutic drugs best documented to cause epiphora are 5-fluorouracil and docetaxel; with both of these drugs, the main mechanism underlying epiphora is canalic... περισσότερα »
Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.
Related Articles *Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.* JAMA Neurol. 2016 Jul 18; Authors: Joubert B, Saint-Martin M, Noraz N, Picard G, Rogemond V, Ducray F, Desestret V, Psimaras D, Delattre JY, Antoine JC, Honnorat J Abstract Importance: Autoantibodies against contactin-associated protein-like 2 (CASPR2) are observed in several neurological syndromes, including neuromyotonia (NMT), Morvan syndrome (MoS), and limbic encephalitis. Obje... περισσότερα »
Shared antigens in cancer immunotherapy [Immunology and Inflammation]
Blockade of inhibitory immune checkpoints (ICPs) has led to impressive clinical regressions in some patients with tumors like lung cancer or melanoma, which often carry a high mutational load (1). Somatic mutations expressed by tumor cells can provide a rich source of neoantigens, and it has been suggested that T... from Melanoma via xlomafota13 on Inoreader http://ift.tt/2a9G6RM
Cerebral Venous Thrombosis: Epidemiology in Change [Editorial]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
http://ift.tt/29SBRGy
Cerebral Venous Sinus Thrombosis Incidence Is Higher Than Previously Thought: A Retrospective Population-Based Study [Original Contribution]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background and Purpose— The incidence of cerebral venous thrombosis (CVT) varies between studies, but it is estimated to be between 2 and 5 per million per year. A recent study in the Netherlands with comprehensive ascertainment suggested a much higher incidence. It is uncertain whether these differing estimates reflect the quality of ascertainment or true variation. The purpose of this study was to determine the incidence of CVT in Adelaide, using a novel clinical and radiological methodology. Methods— We retrospectively identified CVT *International Classification of Diseases... περισσότερα »
Prior Antithrombotic Use Is Associated With Favorable Mortality and Functional Outcomes in Acute Ischemic Stroke [Original Contribution]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background and Purpose— Antithrombotics are the mainstay of treatment in primary and secondary prevention of stroke, and their use before an acute event may be associated with better outcomes. Methods— Using data from Get With The Guidelines-Stroke with over half a million acute ischemic strokes recorded between October 2011 and March 2014 (n=540 993) from 1661 hospitals across the United States, we examined the unadjusted and adjusted associations between previous antithrombotic use and clinical outcomes. Results— There were 250 104 (46%) stroke patients not receiving any ant... περισσότερα »
Endobronchial Pagetoid Spread of a Breast Carcinoma Metastatic to the Lung: A Case Report
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the time of diagnosis it was a T1N0, grade 3 invasive ductal carcinoma, with HER-2 amplification. The lung metastasis measured 1,9 cm and showed the same histology and biological profile of the primary tumor. In addition, numerous neoplastic cells, with large cytoplasm and at... περισσότερα »
Aberrant self-grooming as early marker of motor dysfunction in a rat model of Huntington's disease
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Anna Maria Tartaglione, Monica Armida, Rosa Luisa Potenza, Antonella Pezzola, Patrizia Popoli, Gemma Calamandrei In the study of neurodegenerative diseases, rodent models provide experimentally accessible systems to study multiple pathogenetic aspects. The identification of early and robust behavioural changes is crucial to monitoring disease progression and testing potential therapeutic strategies in animals. Consistent experimental data support the translational value... περισσότερα »
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Neurotrauma , Vol. 0, No. 0. http://ift.tt/29TZsW9
Inflexible ethanol intake: A putative link with the Lrrk2 pathway
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Daniel Almeida da Silva e Silva, Andrea Frozino Ribeiro, Samara Damasceno, Cristiane S. Rocha, Alexandre H. Berenguer de Matos, Roseli Boerngen-Lacerda, Diego Correia, Ana Lúcia Brunialti Godard Alcoholism is a complex multifactorial disorder with a strong genetic influence. Although several studies have shown the impact of high ethanol intake on the striatal gene expression, few have addressed the relationship between the patterns of gene expression underlying the comp... περισσότερα »
Central histaminergic transmission modulates the ethanol induced anxiolysis in mice
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Lokesh Verma, Nishant S. Jain Intrigued by the report demonstrating an increase in brain histamine levels by ethanol administration and central histamine transmission to affect the anxiety related behaviors, the present study examined the permissive role of central histaminergic transmission in the acute anxiolytic-like effect of the ethanol on elevated plus maze (EPM) in mice. Results demonstrated that prior administration of the agents that are known to enhance the br... περισσότερα »
Function of opioidergic and dopaminergic antagonists on both spatial and object novelty detection deficits induced in rodent model of hepatic encephalopathy
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Mohammad Nasehi, Fatemeh Mafi, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast Liver disease has been known for a long time to affect brain function. We now report the function of opioidergic and dopaminergic antagonists on both spatial and object novelty detection deficits induced by hepatic encephalopathy (HE) following bile duct ligation (BDL), a model of chronic liver disease. Assessment of spatial and object novelty detection memories was carried out in the no... περισσότερα »
Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: Implications for object recognition
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Charlotte Bonardi, Marie-Christine Pardon, Paul Armstrong Performance was examined on three variants of the spontaneous object recognition (SOR) task, in 5-month old APPswe/PS1dE9 mice and wild-type littermate controls. A deficit was observed in an object-in-place (OIP) task, in which mice are preexposed to four different objects in specific locations, and then at test two of the objects swap locations (Experiment 2). Typically more exploration is seen of the objects wh... περισσότερα »
Facilitating effects of deep brain stimulation on feedback learning in Parkinson’s disease
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Sarah Nadine Meissner, Martin Südmeyer, Ariane Keitel, Bettina Pollok, Christian Bellebaum Deep brain stimulation (DBS) of the subthalamic nucleus (STN) provides an effective treatment for Parkinson's disease (PD) motor symptoms. However, findings of effects on cognitive function such as feedback learning remain controversial and rare. The aim of the present study was to gain a better understanding of cognitive alterations associated with STN-DBS. Therefore, we investi... περισσότερα »
A novel role for the immunophilin FKBP52 in motor coordination
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Matthew J. Young, Philippine C. Geiszler, Marie-Christine Pardon FKBP52 is a ubiquitously distributed immunophilin that has been associated with wide-ranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and has consequently been associated with stress- and age- related neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Reduced levels of ... περισσότερα »
Inflexible ethanol intake: A putative link with the Lrrk2 pathway
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Daniel Almeida da Silva e Silva, Andrea Frozino Ribeiro, Samara Damasceno, Cristiane S. Rocha, Alexandre H. Berenguer de Matos, Roseli Boerngen-Lacerda, Diego Correia, Ana Lúcia Brunialti Godard Alcoholism is a complex multifactorial disorder with a strong genetic influence. Although several studies have shown the impact of high ethanol intake on the striatal gene expression, few have addressed the relationship between the patterns of gene expression underlying the comp... περισσότερα »
Central histaminergic transmission modulates the ethanol induced anxiolysis in mice
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Lokesh Verma, Nishant S. Jain Intrigued by the report demonstrating an increase in brain histamine levels by ethanol administration and central histamine transmission to affect the anxiety related behaviors, the present study examined the permissive role of central histaminergic transmission in the acute anxiolytic-like effect of the ethanol on elevated plus maze (EPM) in mice. Results demonstrated that prior administration of the agents that are known to enhance the br... περισσότερα »
Function of opioidergic and dopaminergic antagonists on both spatial and object novelty detection deficits induced in rodent model of hepatic encephalopathy
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Mohammad Nasehi, Fatemeh Mafi, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast Liver disease has been known for a long time to affect brain function. We now report the function of opioidergic and dopaminergic antagonists on both spatial and object novelty detection deficits induced by hepatic encephalopathy (HE) following bile duct ligation (BDL), a model of chronic liver disease. Assessment of spatial and object novelty detection memories was carried out in the no... περισσότερα »
Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: Implications for object recognition
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Charlotte Bonardi, Marie-Christine Pardon, Paul Armstrong Performance was examined on three variants of the spontaneous object recognition (SOR) task, in 5-month old APPswe/PS1dE9 mice and wild-type littermate controls. A deficit was observed in an object-in-place (OIP) task, in which mice are preexposed to four different objects in specific locations, and then at test two of the objects swap locations (Experiment 2). Typically more exploration is seen of the objects wh... περισσότερα »
Validation of the Attention-Related Driving Errors Scale (ARDES) in an English-Speaking Sample
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objective: The goal for this study was to develop an English translation of the Attention-Related Driving Errors Scale (ARDES-US) and to determine its potential relationship with driver history and other demographic variables. Background: Individual differences in performance on vigilance and cognitive tasks are well documented, but less is known about susceptibility to attention-related errors while driving. The ARDES has been developed and administered in both Spanish and Chinese but to our knowledge has never been administered or examined in an English-speaking population. Meth... περισσότερα »
Prospecting TCRs for immunotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3529 Author: Zoltan Fehervari (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29MktCE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Interleukin 1α and the inflammatory process
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 906 (2016). doi:10.1038/ni.3503 Authors: Nelson C Di Paolo & Dmitry M Shayakhmetov (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29KPQ4b via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 1005 (2016). doi:10.1038/ni0816-1005c Author: Jonathan S Silver, Jennifer Kearley, Alan M Copenhaver, Caroline Sanden, Michiko Mori, Li Yu, Gretchen Harms Pritchard, Aaron A Berlin, Christopher A Hunter, Russell Bowler, Jonas S Erjefalt, Roland Kolbeck & Alison A Humbles (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29MkhDo via IFTTT Medicine by […]
Dengue suppresses MAVS
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3527 Author: Laurie A Dempsey (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29KQ6jr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 1005 (2016). doi:10.1038/ni0816-1005b Author: Christophe Pedros, Yaoyang Zhang, Joyce K Hu, Youn Soo Choi, Ann J Canonigo-Balancio, John R Yates, Amnon Altman, Shane Crotty & Kok-Fai Kong (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29Mk7fn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A Nod to type 1 diabetes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3530 Author: Zoltan Fehervari (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29KQf6J via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Erratum: IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 1005 (2016). doi:10.1038/ni0816-1005a Author: Yoichiro Ohne, Jonathan S Silver, LuAnn Thompson-Snipes, Magalie A Collet, Jean Philippe Blanck, Brandi L Cantarel, Alan M Copenhaver, Alison A Humbles & Yong-Jun Liu (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29MkIO0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mind over tumor
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3528 Author: Laurie A Dempsey (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29KQ1MR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The protective crypt
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 905 (2016). doi:10.1038/ni.3526 Author: Ioana Visan (Source: Nature Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29MkaYq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A dRAStic RHOAdblock of Pyrin inflammasome activation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature Immunology 17, 900 (2016). doi:10.1038/ni.3511 Authors: Andrea Dorfleutner & Christian Stehlik The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised in response to defects in the mevalonate pathway and is disabled directly by mutations in the gene encoding Pyrin, which results in the interleukin 1β (IL-1β)-driven autoinflammatory diseases […]
Current concepts in salvage procedures for failing microvascular flaps: is there a superior technique? Insights from a systematic review of the literature
Microvascular free tissue transfer is a routine procedure with high predictability and a low complication rate. However, compromised flap perfusion remains a challenge and there is no consensus regarding the appropriate flap salvage protocol. The purpose of this study was to identify techniques with implications for flap salvage procedures and to assess their efficacy. A systematic review of studies published in the literature between 1990 and 2015, with predefined inclusion and exclusion criteria, was performed. http://ift.tt/29Nf25w
Xenogeneic Cardiac Extracellular Matrix Scaffolds With or Without Seeded Mesenchymal Stem Cells Exhibit Distinct In Vivo Immunosuppressive and Regenerative Properties
Publication date: Available online 18 July 2016 *Source:*Acta Biomaterialia Author(s): Angela Papalamprou, Chia Wei Chang, Natalia Vapniarsky, Alycia Clark, Naomi Walker, Leigh G. Griffiths Cardiac extracellular matrix (cECM) scaffolds are promising biomaterials for reconstructive surgery applications since they possess the structure/function properties of native tissue. Production of cECM scaffolds has been achieved using decellularization approaches, which commonly employ denaturing detergents, such as sodium dodecyl sulfate (SDS). Our antigen removal (AR) method has been shown to r... περισσότερα »
EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla
This study aimed to investigate the roles of ephrinB2 in stabilizing vascularlike structures generated by stem cells from apical papilla (SCAPs) and human umbilical vein endothelial cells (HUVECs). http://ift.tt/29Z8sfy
Fractures of the Facial Skeleton, 2nd Edition
Michael Perry Fractures of the Facial Skeleton, Second Edition gives a clear, concise and practical overview of the management of maxillofacial injuries. This new edition has been fully updated to... Read more » http://ift.tt/2af8bXy
Buttress guide: direct positioning splint to align a complex fracture of the zygoma
Anterolateral projection of the middle third of the face is controlled by the position of the zygoma. Traumatic displacement of the zygomatic complex can cause restricted mouth opening, orbital symptoms, and invariably, facial asymmetry, so primary reduction is necessary to re-establish symmetry. http://ift.tt/29SvAPj
Marsupialisation of kerastocystic odontogenic tumours in a patient with Simpson-Golabi-Behmel syndrome
Simpson-Golabi-Behmel syndrome is a rare multiple, X-linked, congenital disorder, with a wide phenotypic spectrum that includes congenital malformations, macrocephaly, macrostomy, hypoplastic nails, polydactyly, syndactyly, and mild to moderate developmental delay.1 http://ift.tt/29Sol5S
Ramipril + amlodipine and ramipril + hydrochlorothiazide fixed-dose combinations in relation to patient adherence
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To compare 1-year treatment adherence of ramipril + amlodipine and ramipril +hydroclorothiazide fixed-dose combination therapies in patients with hypertension. Methods Data were extracted from the database of the National Health Insurance Fund of Hungary. Treatment adherence was modelled using survival analysis. Results At 2 months after initiation of treatment, 42% of patients using ramipril […]
Presentation to Emergency Departments for Acute Rhinosinusitis: Disparities in Symptoms by Race and Insurance Status
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Medicaid and self-pay insurance statuses and race are associated with emergency department (ED) presentation for uncomplicated acute rhinosinusitis (ARS). We investigated whether ARS symptomatology could explain this disproportionate ED use. Study Design 2006-2010 National Hospital Ambulatory Medical Care Surveys. Setting EDs in the United States. Subjects and Methods The data comprise 1,632,826 adult visits […]
A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity
The mammalian superior colliculus (SC) is a midbrain structure that integrates multimodal sensory inputs and computes commands to initiate rapid eye movements. SC neurons burst with the sudden onset of a visual stimulus, followed by persistent activity that may underlie shifts of attention and decision making. Experiments in vitro suggest that circuit reverberations play a role in the burst activity in the SC, but the origin of persistent activity is unclear. In the present study we characterized an afterdepolarization (ADP) that follows action potentials in slices of rat SC. Popu... περισσότερα »
Regionally distinct cutaneous afferent populations contribute to reflex modulation evoked by stimulation of the tibial nerve during walking
During walking, cutaneous reflexes in ankle flexor muscle [tibialis anterior (TA)] evoked by tibial nerve (TIB) stimulation are predominantly facilitatory at early swing phase but reverse to suppression at late swing phase. Although the TIB innervates a large portion of the skin of the foot sole, the extent to which specific foot-sole regions contribute to the reflex reversals during walking remains unclear. Therefore, we investigated regional cutaneous contributions from discrete portions of the foot sole on reflex reversal in TA following TIB stimulation during walking. Summation... περισσότερα »
Facilitating effects of deep brain stimulation on feedback learning in Parkinson’s disease
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Sarah Nadine Meissner, Martin Südmeyer, Ariane Keitel, Bettina Pollok, Christian Bellebaum Deep brain stimulation (DBS) of the subthalamic nucleus (STN) provides an effective treatment for Parkinson's disease (PD) motor symptoms. However, findings of effects on cognitive function such as feedback learning remain controversial and rare. The aim of the present study was to gain a better understanding of cognitive alterations associated with STN-DBS. Therefore, we investi... περισσότερα »
A novel role for the immunophilin FKBP52 in motor coordination
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Matthew J. Young, Philippine C. Geiszler, Marie-Christine Pardon FKBP52 is a ubiquitously distributed immunophilin that has been associated with wide-ranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and has consequently been associated with stress- and age- related neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Reduced levels of ... περισσότερα »
Aberrant self-grooming as early marker of motor dysfunction in a rat model of Huntington's disease
[image: alertIcon.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Anna Maria Tartaglione, Monica Armida, Rosa Luisa Potenza, Antonella Pezzola, Patrizia Popoli, Gemma Calamandrei In the study of neurodegenerative diseases, rodent models provide experimentally accessible systems to study multiple pathogenetic aspects. The identification of early and robust behavioural changes is crucial to monitoring disease progression and testing potential therapeutic strategies in animals. Consistent experimental data support the translational value... περισσότερα »
M100907 attenuates elevated grooming behavior in the BTBR mouse
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Dionisio A. Amodeo, Elaine Rivera, Jeffrey T. Dunn, Michael E. Ragozzino Individuals with autism spectrum disorder (ASD) exhibit social-communication deficits along with restricted interests and repetitive behaviors (RRBs). To date, there is a lack of effective treatments to alleviate RRBs. A recent study found that treatment with the 5HT2A receptor antagonist M100907 attenuates a reversal learning deficit in the BTBR mouse model of autism. The BTBR mouse also exhibits... περισσότερα »
Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats
[image: S01664328.gif] Publication date: 15 October 2016 *Source:*Behavioural Brain Research, Volume 313 Author(s): Laura Reck Cechinel, Carla Giovana Basso, Karine Bertoldi, Bruna Schallenberger, Louisiana Carolina Ferreira de Meireles, Ionara Rodrigues Siqueira Some studies have linked age-related beneficial effects of exercise and epigenetic mechanisms. Although, the impact of treadmill exercise on histone acetylation, histone and DNA methylation marks in aged cortices yet remains poorly understood. Considering the role of frontal cortex on brain functions, we investigated the po... περισσότερα »
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/29TZsW9 via IFTTT
Clinical Spectrum of HLA-B27-associated Ocular Inflammation.
Authors: Pathanapitoon K, Dodds EM, Cunningham ET, Rothova A Abstract Human leukocyte antigen (HLA)-B27-associated anterior uveitis (AU) is the most commonly diagnosed form of AU and represents the largest entity of non-infectious uveitis around the world. The most typical ocular manifestation associated with HLA-B27 consists of unilateral AU of acute onset. The HLA-B27-associated acute AU… Continue reading Clinical Spectrum of HLA-B27-associated Ocular Inflammation.
Public health and chronic low chlordecone exposures in Guadeloupe; Part 2: Health impacts, and benefits of prevention
Abstract Background Inhabitants of Guadeloupe are chronically exposed to low doses of chlordecone via local food due to its past use in banana plantations. The corresponding health impacts have not been quantified. We develop a quantitative method and present the results in two articles: 1. Hazard identification, exposure-response functions, and exposure, 2. Health impacts, and… Continue reading Public health and chronic low chlordecone exposures in Guadeloupe; Part 2: Health impacts, and benefits of prevention
Ankylosing Spondylitis Patients with HLA-B*2704 have More Uveitis than Patients with HLA-B*2705 in a North Chinese Population.
CONCLUSIONS: AS patients with B*2704 have a higher risk of uveitis than AS with B*2705 in a north Chinese people. PMID: 27428175 [PubMed – as supplied by publisher] (Source: Ocular Immunology and Inflammation) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29MheuV via IFTTT
Low positive rate of serum autoantibodies in colorectal cancer patients without systemic rheumatic diseases.
CONCLUSIONS: The CTD assay shows a low false positive rate for detecting autoantibodies in a clinical context of CRC. PMID: 27424781 [PubMed – as supplied by publisher] (Source: Autoimmunity) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29KN52O via IFTTT
