4-Amino-6-alkyloxy-2-alkylthiopyrimidine Derivatives as Novel Non-nucleoside Agonists for the Adenosine A1 Receptor
Abstract Three 4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives (4-6) were investigated as potential non-nucleoside agonists at human adenosine receptors (ARs). When tested in competition binding experiments, these compounds exhibited low micromolar affinity (Ki values comprised between 1.2 and 1.9 μM) for the A1 AR and no appreciable affinity for the A2A and A3 ARs. Evaluation of their efficacy profiles by measurement of intracellular cAMP levels revealed that 4 and 5 behave as non-nucleoside agonists of the A 1 AR with EC50 values of 0.47 μM and 0.87 μM, respectively. No clear... περισσότερα »
Structure-Activity Relationship Studies of Benzyl, Phenethyl and Pyridyl Substituted Tetrahydroacridin-9-amines as Multi-targeting Agents to treat Alzheimer's Disease
Abstract A library of substituted tetrahydroacridin-9-amine derivatives were designed, synthesized and evaluated as dual cholinesterase and amyloid aggregation inhibitors. Compound 8e (*N-*(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine), was identified as a potent inhibitor of butyrylcholinesterase (BuChE IC50 = 20 nM; AChE IC50 = 2.2 μM) and was able to inhibit amyloid aggregation (40% inhibition at 25 μM). Compound 9e (6-chloro-*N-*(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine, AChE IC50 = 0.8 μM; BuChE IC50 = 1.4 μM; Aβ-aggregation inhibition = 75.7% inhibitio... περισσότερα »
Dietary flavonoid intake and the risk of stroke: a dose-response meta-analysis of prospective cohort studies
Objective To clarify and quantify the potential association between intake of flavonoids and risk of stroke. Design Meta-analysis of prospective cohort studies. Data source Studies published before January 2016 identified through electronic searches using PubMed, Embase and the Cochrane Library. Eligibility criteria for selecting studies Prospective cohort studies with relative risks and 95% CIs for stroke according to intake of flavonoids (assessed as dietary intake). Results The meta-analysis yielded 11 prospective cohort studies involving 356 627 participants and more tha... περισσότερα »
Trends of CT utilisation in an emergency department in Taiwan: a 5-year retrospective study
Objectives To investigate the association between the trends of CT utilisation in an emergency department (ED) and changes in clinical imaging practice and patients' disposition. Setting A hospital-based retrospective observational study of a public 1520-bed referral medical centre in Taiwan. Participants Adult ED visits (aged ≥18 years) during 2009–2013, with or without receiving CT, were enrolled as the study participants. Main outcome measures For all enrolled ED visits, we retrospectively analysed: (1) demographic characteristics, (2) triage categories, (3) whether CT was... περισσότερα »
Nerve-insulating cells more diverse than previously thought
Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study by researchers at Karolinska Institutet in Sweden. The findings, published in the journal Science, will help increase our understanding of diseases in which these cells are affected and possibly provide clues to future treatment strategies. In multiple sclerosis and similar neurological diseases, the electrical signals in the brain propagate more slowly. The reduced speed of information flow contribute... περισσότερα »
The essential function of the Trypanosoma brucei Trl1 homolog in procyclic cells is maturation of the intron-containing tRNATyr [ARTICLE]
*Trypanosoma brucei*, the etiologic agent of sleeping sickness, encodes a single intron-containing tRNA, tRNATyr, and splicing is essential for its viability. In Archaea and Eukarya, tRNA splicing requires a series of enzymatic steps that begin with intron cleavage by a tRNA-splicing endonuclease and culminates with joining the resulting tRNA exons by a splicing tRNA ligase. Here we explored the function of TbTrl1, the *T. brucei* homolog of the yeast Trl1 tRNA ligase. We used a combination of RNA interference and molecular biology approaches to show that down-regulation of TbTrl1... περισσότερα »
Nucleotide specificity of the human terminal nucleotidyltransferase Gld2 (TUT2) [ARTICLE]
The nontemplated addition of single or multiple nucleotides to RNA transcripts is an efficient means to control RNA stability and processing. Cytoplasmic RNA adenylation and the less well-known uridylation are post-transcriptional mechanisms regulating RNA maturation, activity, and degradation. Gld2 is a member of the noncanonical poly(A) polymerases, which include enzymes with varying nucleotide specificity, ranging from strictly ATP to ambiguous to exclusive UTP adding enzymes. Human Gld2 has been associated with transcript stabilizing miRNA monoadenylation and cytoplasmic mRNA ... περισσότερα »
Evaluation of microRNA alignment techniques [BIOINFORMATICS]
Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses considerable challenges due to their short length (~21 nucleotides [nt]) as well as the large size and complexity of plant and animal genomes. While several tools have been developed for high-throughput mapping of longer mRNA-seq reads (>30 nt), there are few that are specifically designed for mapping of smRNA reads including microRNAs. The accuracy of these mappers has not been systematically determined in the case of smRNA-seq. In addition, it is unknown whether these aligners accurately map smRNA reads con... περισσότερα »
Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway
Publication date: August 2016 *Source:*Free Radical Biology and Medicine, Volume 97 Author(s): Bowen Wu, Hao Yu, Yifan Wang, Zongfu Pan, Yihan Zhang, Tong Li, Lu Li, Weichen Zhang, Lijun Ge, Ying Chen, Choe Kyong Ho, Danyan Zhu, Xin Huang, Yijia Lou Protein nitrosylation is a ubiquitous post-translational modification in almost all biological systems. However, its function on stem cell biology is so far incompletely understood. Here, we demonstrated that peroxiredoxin 2 (Prdx-2) nitrosylation was involved in cardiomyocyte differentiation of mouse embryonic stem (ES) cells induced by... περισσότερα »
Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway
Publication date: August 2016 *Source:*Free Radical Biology and Medicine, Volume 97 Author(s): Mingtao Chang, Yang Li, Dong Liu, Lianyang Zhang, Hongguang Zhang, Hao Tang, Huayu Zhang Exogenous administration of melatonin has been demonstrated to down-regulate inflammatory responses and attenuate organ damage in various models. However, the salutary effect of melatonin against secondary intra-abdominal hypertension (IAH) remains unclear. This study sought to test the influence of melatonin on secondary IAH in a pathophysiological rat model and the underlying mechanisms involved. Bef... περισσότερα »
Design and characterization of novel all-solid-state potentiometric sensor array dedicated to physiological measurements
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Renata Toczyłowska-Mamińska, Monika Kloch, Anna Zawistowska-Deniziak, Agnieszka Bala A novel construction of all-solid-state potentiometric sensor array designed for physiological measurements has been presented. The planar construction and elimination of liquid phase creates broad opportunities for the modifications in the sensing part of the sensor. The designed construction is based on all-solid-state ion-selective electrodes integrated with the ionic-liquid based reference electrode. Work parameters of the... περισσότερα »
An improved matrix separation method for characterization of ultrapure germanium (8N)
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): M.A. Reddy, R. Shekhar, Sunil Jai Kumar An improved matrix separation method has been described to characterize ultrapure germanium of 8N (99.999999%) purity. In this method, temperature of the reaction vessel in which in-situ generated chlorine gas reacts with germanium solid material directly is optimized to quantitatively remove Ge matrix from all its impurities. Optimized reaction temperature has been found to be 230±5°C. Recovery studies on more than 60 elements have been carried out at the optimized tempe... περισσότερα »
Selective adsorption of hemoglobin with polyoxometalate-derived hybrid by solidification of super-lacunary phosphotungstate polyoxoanions
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Dan-Dan Zhang, Lin-Lin Hu, Qing Chen, Xu-Wei Chen, Jian-Hua Wang A novel polyoxometalate (POM)-based hybrid P8W48-APTS is prepared by the solidification of super-lacunary P8W48O18440- polyoxoanions with APTS in an acidic medium. The oxygen (O−) atoms in P8W48O18440- are bound to silicon atoms in APTS by the formation of Si-O linkage through dehydration condensation. The solidification is confirmed by characterizations with XRD, FT-IR, TGA, SEM and EDXS. Selective isolation of proteins of interest, hemoglobin (H... περισσότερα »
Understanding microwave vessel contamination by chloride species
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Sandro Recchia, Davide Spanu, Davide Bianchi, Carlo Dossi, Andrea Pozzi, Damiano Monticelli Microwaves are widely used to assist digestion, general sample treatment and synthesis. The use of aqua regia is extensively adopted for the closed vessel mineralization of samples prior to trace element detection, leading to the contamination of microwave vessels by chlorine containing species. The latter are entrapped in the polymeric matrix of the vessels, leading to memory effects that are difficult to remove, among ... περισσότερα »
The use of graphene nanoribbons as efficient electrochemical sensing material for nitrite determination
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Eda Mehmeti, Dalibor M. Stanković, Ahmet Hajrizi, Kurt Kalcher In this work new designed, highly sensitive electrochemical method is developed for the determination of nitrites in tap water using glassy carbon electrode modified with graphene nanoribbons (GNs/GCE). Graphene nanoribbons (GNs) have been newly synthetized and aligned to the surface of glassy carbon electrode (GCE) and exhibited excellent electrocatalytic activity for nitrite oxidation with a very high peak currents. Studies about electrochemical b... περισσότερα »
Anaplastic thyroid carcinoma presenting with gastric metastasis
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Hippokratia. Authors: Ayaz T, Sahin SB, Sahin OZ, Akdogan R, Gücer R Abstract INTRODUCTION: Anaplastic thyroid carcinoma (ATC) has the most aggressive progression among thyroid malignancies. Most of the patients have metastasis, especially to the lungs, liver and regional lymph nodes, at the time of diagnosis. Gastrointestinal tract metastasis of ATC has been rarely reported. We report a case who presented with gastrointestinal bleeding and was diagnosed with ATC accompanied with gastric, skin, lung and adrenal gland metastases.... περισσότερα »
Paraproteinemia and central retinal vein occlusion.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] EI Agorogiannis1 and V Kotamarthi2 1St Paul’s Eye Unit, Royal Liverpool Hospital, Liverpool 2Department of Ophthalmology, Leighton Hospital, Crewe United Kingdom Eleftherios I. Agorogiannis, St Paul’s Eye Unit, Royal Liverpool Hospital, Prescot Street, Liverpool, L7 8XP, United Kingdom ; Email: moc.liamg@sinnaigoroga.soirehtfele Author information ▼ Article notes ► Copyright and License information ► Go to: Dear Editor, A 70-year-old male presented two weeks following sudden painless loss of left eye vision. His medical history included... περισσότερα »
Post Kala Azar dermal leishmaniasis in a 15-month-old Greek boy.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] D Doganis,1 M Mavrikou,1 and M Tsolia2 1First Department of Pediatrics, School of Medicine, National and Kapodistrian University P. and A. Kyriakou Children's Hospital, Athens, Greece 2Second Department of Pediatrics School of Medicine, National and Kapodistrian University P. and A. Kyriakou Children's Hospital, Athens, Greece Doganis Dimitrios, Thivon & Levadias Str, 11527 Athens, Greece, tel: +302107452211, Fax: +302132009104, Email: moc.liamg@dsinagod Author information ▼ Article notes ► Copyright and License information ► Go to... περισσότερα »
Sevoflurane induction of anesthesia for a large epiglottic cyst removal when awake intubation is not an option.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] G Tsaousi, Ch Pourzitaki, and E Amaniti Department of Anesthesiology and Intensive Care, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece Pourzitaki Chryssa, Department of Anesthesiology and Intensive Care, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece ; Email: moc.liamg@ruophc Author information ▼ Article notes ► Copyright and License information ► Go to: Dear Editor, Epiglottic cysts, although rare, may hinder tracheal intubation while the anesthetist may encounter... περισσότερα »
Lleft inferior vena cava with azygous continuation and presence of the suprarenal segment of a right inferior vena cava.
A rare case of [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] D Papoutsis1 and E Tsatsali Foroglou2 1Department of Maternity, Royal Shrewsbury Hospital, Shrewsbury, United Kingdom 2Radiology Department, EUROMEDICA Radiology Center, Thessaloniki, Greece Papoutsis D, Royal Shrewsbury Hospital, Shrewsbury, United Kingdom, tel: +4401952641222 dimitrios.pa- Email: ten.shn@sistuop Author information ▼ Article notes ► Copyright and License information ► Go to: Dear Editor, The inferior vena cava (IVC) is a single vein located to the right of the abdominal aorta. When failure in the proce... περισσότερα »
Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma.
[image: http:--www.nature.com-images-lo_bjc.gif] Authors: Wang C, Guan S, Liu F, Chen X, Han L, Wang D, Nesa EU, Wang X, Bao C, Wang N, Cheng Y Abstract BACKGROUND: Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level and the potential for the diagnosis and prognosis in oesophageal squamous cell cancer (ESCC). METHODS: We examined miR-146a expression in 62 pairs of ESCC cancerous and matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tiss... περισσότερα »
Esophageal cancer is one of the rarer solid tumors that metastasize to the central nervous system
An Uncommon Complication of Esophageal Cancer.: Conn Med. 2016 ; Authors: Akbar SN, Hermel DJ, Alday G Abstract Esophageal cancer is one of the rarer solid tumors that metastasize to the central nervous system. We describe a case of a 57-year-old male, previously confirmed to have *obstructive esophageal adenocarcinoma with local mediastinal and esophagogastric lymph node involvement* undergoing chemotherapy, who presented with altered mental status, headache, nausea, 15-pound weight loss, and neck stiffness. Prior staging with an MRI of the brain and spine was unrevealing, but a lu... περισσότερα »
Surgical treatment of long bone metastases : Microwave ablation combined with curettage appears to be a safe and effective approach in the surgical treatment of long bone metastases, which can relieve local pain and control the local development of bone metastases.
[Clinical Analysis of Surgical treatment of long bone metastases].: Zhonghua Yi Xue Za Zhi. 2016;96(19):1500-1504 Authors: Li Y, Sun Y, Shan HC, Niu XH Abstract Objective: To evaluate the safety and efficacy of microwave ablation combined with curettage in the treatment of long bone metastases. Methods: From April 2010 to June 2015, 38 patients with long bone metastases were adopted, who all underwent microwave ablation combined with curettage with 40 lesions involved in Department of Orthopaedic Oncology, Beijing Jishuitan Hospital. There were 22 males and 16 females with an avera... περισσότερα »
The Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma.
Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma.: Clin Oncol (R Coll Radiol). 2016 Jun ; Authors: Ward G, Ramasamy S, Sykes JR, Prestwich R, Chowdhury F, Scarsbrook A, Murray P, Harris K, Crellin A, Hatfield P, Sebag-Montefiore D, Spezi E, Crosby T, Radhakrishna G Abstract AIMS: To investigate the use of image co-registration in incorporating diagnostic positron emission tomography-computed tomography (PET-CT) directly into the ... περισσότερα »
lncRNA UCA1 inhibits esophageal squamous-cell carcinoma growth by regulating the Wnt signaling pathway.
lncRNA UCA1 inhibits esophageal squamous-cell carcinoma growth by regulating the Wnt signaling pathway.: J Toxicol Environ Health A. 2016;79(9-10):407-418 Authors: Wang X, Gao Z, Liao J, Shang M, Li X, Yin L, Pu Y, Liu R Abstract Esophageal squamous-cell carcinoma (ESCC) is one of the most common tumors worldwide. Recent studies suggested that long noncoding RNAs (lncRNAs) might play a key role in regulating cellular processes and cancer progression. One of the lncRNAs, urothelial carcinoma associated 1 (UCA1), is known to be dysregulated in several cancers, including bladder carc... περισσότερα »
Endoscopic Ultrasound Staging of Upper Gastrointestinal Malignancies.
Endoscopic Ultrasound Staging of Upper Gastrointestinal Malignancies.: Asian Pac J Cancer Prev. 2016;17(5):2361-2367 Authors: Saadany SE, Mayah W, Kalla FE, Atta T Abstract Since 1980, endoscopic ultrasound (EUS) has been used as an important tool for the evaluation of malignant diseases in hollow viscus and bilio-pancreas, as well as sub-epithelial tumors. The high-resolution capacity and low penetration depth of EUS make it possible to obtain highly detailed images of the gastrointestinal wall and immediate surroundings to a depth of 4-5 cm. Thus, over the past 35 years, EUS succ... περισσότερα »
Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN)
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.: Asian Pac J Cancer Prev. 2016;17(5):2679-2681 Authors: Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J Abstract BACKGROUND: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) are relatively rare tumors, not equally distributed in the gastrointestinal system. In 2010, a revised version of the WHO classification of GEP-NENs was published. This study reports for the first time the distribution and characteristics of GEP-N... περισσότερα »
Three-Dimensional Thoracolaparoscopy in Esophageal Cancer Surgery.
First Experience with J Laparoendosc Adv Surg Tech A. 2016 Jun ; Authors: van der Kaaij RT, van Sandick JW, van der Peet DL, Buma SA, Hartemink KJ Abstract INTRODUCTION: Endoscopic techniques are rapidly gaining interest in esophageal cancer surgery due to lower pulmonary complication rates and faster postoperative recovery. Conventional two-dimensional endoscopic surgery has two main limitations: lack of depth perception and limited dexterity due to the use of rigid instruments. Theoretically, three-dimensional (3D) endoscopy can overcome these limitations, but to date, its use... περισσότερα »
Transcervical upper mediastinal dissection for esophageal malignancy by robot-assisted surgery.
Preclinical study of Int J Med Robot. 2016 Jun ; Authors: Mori K, Yoshimura S, Yamagata Y, Aikou S, Seto Y Abstract BACKGROUND: Robotic surgical systems are potentially applicable to transcervical mediastinal lymph dissection for esophageal malignancy. METHODS: Robot-assisted surgery was performed on a male fresh-frozen human cadaver. Devices for single-port laparoscopic surgery were deployed via one small incision in the left clavicular area. The task for the robot-assisted surgery was the upper mediastinal dissection to the level of the left main bronchus and en bloc harvest of ... περισσότερα »
The management of patients with esophageal cancer and coronary artery stenosis undergoing radiotherapy or concurrent chemoradiotherapy
a single-center experience.: J BUON. 2016 Authors: Luo H, Chen X, Zhang Q, Wang L, Qiao L, Liang N, Xie J, Yu X, Song M, Liu Z, Lv Y, Liu F, Tian Y, Cheng J, Deng G, Zhang J, Li XA, Zhang J Abstract PURPOSE: The incidence of esophageal cancer (EC) patients with coronary artery stenosis presents particular challenges. The aim of this retrospective study was to evaluate the efficiency of management on patients with both diseases treated by radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). METHODS: Fifty-three patients with both EC and coronary artery stenosis from June 200... περισσότερα »
Risk for Barrett's esophagus and esophageal adenocarcinoma.
Determination of risk for Curr Opin Gastroenterol. 2016 Jul;32(4):319-324 Authors: Thrift AP Abstract PURPOSE OF REVIEW: The incidence of esophageal adenocarcinoma and its precursor, Barrett's esophagus, have increased greatly over the past 40 years and continue to rise. This report summarizes the most recent data on the risk factors for Barrett's esophagus and esophageal adenocarcinoma. RECENT FINDINGS: Other factors, highly correlated with increasing trends for obesity, are the dominant driver of the increase in incidence of esophageal adenocarcinoma, interacting with gastroe... περισσότερα »
Does the Papilla Preservation Flap Technique Induce Soft Tissue Modifications over Time in Endodontic Surgery Procedures?
Does the Papilla Preservation Flap Technique Induce Soft Tissue Modifications over Time in Endodontic Surgery Procedures?: [image: gr1.sml] The aim of the present controlled clinical trial was to compare 2 incision techniques, papilla base incision (PBI) and sulcular incision (IS), evaluating changes in papilla and recession height over a 12-month period. AbstractIntroduction The aim of the present controlled clinical trial was to compare 2 incision techniques, papilla base incision (PBI) and sulcular incision (IS), evaluating changes in papilla and recession height over a ... περισσότερα »
Horizontal Ridge Augmentation using GBR with a Native Collagen Membrane and 1:1 Ratio of Particulated Xenograft and Autologous Bone
A 1-Year Prospective Clinical Study: Abstract Aim To clinically and radiographically evaluate bone regeneration of severe horizontal bone defects. Materials and Methods This study was designed as a single cohort, prospective clinical trial. Partially or fully edentulous patients, having less then 4 mm of residual horizontal bone width were selected and consecutively treated with resorbable collagen membranes and a 1:1 mixture of particulated anorganic bovine bone and autogenous bone, 7 months before implant placement. Tapered body implants were inserted and loaded 3 to 6 months lat... περισσότερα »
Th17-related cytokines in mucositis: is there any difference between peri-implantitis and periodontitis patients?
Th17-related cytokines in mucositis: is there any difference between peri-implantitis and periodontitis patients?: [image: cover.gif?v=1&s=9b22a7dfcee6ec9da8eaeda8] Abstract Objective This study aimed to compare Th17-related cytokines named IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in peri-implant fluid (PIF) from mucositis sites in patients having either peri-implantitis, periodontitis or without interproximal alveolar bone loss. Material and methods Thirty-three patients diagnosed with peri-implant mucositis were... περισσότερα »
Long-term evaluation of sinus floor elevation using a modified lateral approach in the posterior maxilla
Long-term evaluation of sinus floor elevation using a modified lateral approach in the posterior maxilla: [image: cover.gif?v=1&s=9b22a7dfcee6ec9da8eaeda8] Abstract Objectives The aim of this study was to evaluate the hybrid technique, which was modified from the lateral approach in sinus elevation by combining transalveolar access. Materials and methods Sixty patients (mean age of 53.3 ± 11.6 years) with 105 implants placed in the posterior maxilla with the average remaining bone height (RBH) of 4.3 ± 1.8 mm (range of 1.2–9.2 mm) were enrolled in the hybrid group and followed u... περισσότερα »
Potential reformatting errors in cone-beam computed tomography for dentoalveolar surgery
a cautionary tale: We describe the removal of a lower second molar tooth in which preoperative cone-beam computed tomography (CBCT) showed that the inferior alveolar nerve (IAN) was encased in the distal apex of the root of the tooth. During surgery the nerve was found to be entirely separate from the apex of the root and not involved. With the wider use of CBCT in the treatment planning of dentoalveolar surgery, this case represents a cautionary tale to the clinician on reliance on clinical imaging and software in guiding the decision making process.
Efficacy of petrosectomy in malignant invasion of the temporal bone
Efficacy of petrosectomy in malignant invasion of the temporal bone: We present the outcomes of lateral, subtotal, and total petrosectomies in patients with invasion of the temporal bone by specific primary cancers, with particular emphasis on survival in the advanced stages of disease. We made a retrospective study of 20 consecutive patients (squamous cell carcinoma of the temporal bone, n=11, and primary cancer of the parotid gland with infiltration of the lateral skull base, n=9) treated by total, subtotal, or lateral petrosectomy at the University Department of Otolaryngology, a... περισσότερα »
Head and neck cancer immunology and immunotherapeutics
Basic concepts to clinical translational approaches: In the following series of review articles, we present timely and in depth analyses on the current state of the art in immunology and immunotherapeutics of head and neck squamous cell carcinomas (HNSCC) from thought leaders in the field. This review series evolved in part out of two separate meetings focused on HNSCC immunotherapy. The first meeting was a National Cancer Institute sponsored Clinical Trials Planning Meeting (CTPM) on Immunotherapy in Head & amp; Neck Cancer (November 9–10, 2014), which focused on development of nationa... περισσότερα »
A predictor of osteoporosis using the Klemetti classification
Validation of cone-beam computed tomography as a predictor of osteoporosis using the Klemetti classification: Abstract This study aimed at evaluating the validity of cone-beam computed tomography (CBCT) for assessing mandibular bone quality using the Klemetti classification. The morphology of the endosteal mandibular cortex of 30 (60 hemi-mandibles) postmenopausal women between the ages of 45 and 80 years was evaluated based on the Klemetti classification in panoramic radiographs used as reference images. Afterwards, panoramic reconstruction and cross-sectional slices of CBCT examin... περισσότερα »
Experimental Face Transplantation Study in an Experimental Model.
Experimental Face Transplantation Study in an Experimental Model.: Face allotransplantation represents a novel frontier in complex human facial defect reconstruction. To develop more refined surgical techniques and yield fine results, it is first imperative to make a suitable animal model. The development of a composite facial allograft model in swine is more appealing: the facial anatomy, including facial nerve and vascular anatomy, is similar to that of humans. Two operative teams performed simultaneously, one assigned to harvest the donor and the other to prepare the recipient in ... περισσότερα »
Feed-forward and Reciprocal Inhibition for Gain and Phase Timing Control in a Computational Model of Repetitive Cough
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 15 δευτερόλεπτα
We investigated the hypothesis, motivated in part by a coordinated computational cough network model, that second-order neurons in the nucleus tractus solitarius (NTS) act as a filter that shapes afferent input to the ventral respiratory network (VRC) during the production of cough. In vivo experiments were conducted on anesthetized spontaneously breathing cats. Cough was elicited by mechanical stimulation of the intrathoracic airways. Electromyograms of the parasternal (inspiratory) and rectus abdominis (expiratory) muscles and esophageal pressure were recorded. In vivo data reve... περισσότερα »
The action of the diaphragm on the rib cage
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 15 δευτερόλεπτα
When the diaphragm contracts, pleural pressure falls, exerting a caudal and inward force on the entire rib cage. However, the diaphragm also exerts forces in the cranial and outward direction on the lower ribs. One of these forces, the "insertional force", is applied by the muscle at its attachments to the lower ribs. The second, the "appositional force", is due to the transmission of abdominal pressure to the lower rib cage in the zone of apposition. In the control condition at FRC, the effects of these two forces on the lower ribs are nearly equal and outweigh the effect of pleu... περισσότερα »
The Correlation Between Brain Near-Infrared Spectroscopy and Cerebral Blood Flow in Piglets with Intracranial Hypertension
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 15 δευτερόλεπτα
Cerebral perfusion pressure (CPP) is used as a surrogate for measurement of cerebral blood flow (CBF) but its determination requires that intracranial pressure be directly measured. Near-infrared spectroscopy (NIRS) can non-invasively measure tissue oxygenation. We hypothesized that NIRS would correlate well with CBF, with cerebral metabolism of oxygen (CMRO2) and glucose and with lactate production as CPP was reduced. Seven anesthetized piglets were subjected to reductions in CPP to 60, 50, 40, 30 and 20 mmHg by infusing an artificial cerebral spinal fluid into the lateral ventric... περισσότερα »
The different effects of strength and endurance exercise training on COX-2 and mPGES-expression in mouse brain are independent of peripheral inflammation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 15 δευτερόλεπτα
Acute endurance exercise has been shown to modulate COX-2-expression, which is suggested to affect neuronal plasticity and learning. Here, we investigated the effect of regular strength and endurance training on cerebral COX-2-expression, inflammatory markers in the brain and circulating cytokines. Male C57BL/6N mice were assigned to either a sedentary control group (CG), an endurance training group (EG; treadmill running for 30 min/day, 5x/week, 10 weeks) or a strength training group (SG; strength training by isometric holding, same duration as EG). Four days after the last bout ... περισσότερα »
(Almost) Stationary Isotachophoretic Concentration Boundary in a Nanofluidic Channel Using Charge Inversion
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b01701 [image: ancham?d=yIl2AUoC8zA] [image: 22WYWfx] from #Medicine via ola Kala on Inoreader http://ift.tt/28oPo0W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rfJxJi via IFTTT
Trials Produce Practice-Changing Results for Brain Cancer
The standard treatment that some patients with brain cancer receive is likely to change, based on findings from two large clinical trials presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago this week. Both trials showed that administering the chemotherapy drug temozolomide (Temodar®) in addition to radiation therapy increased how long patients lived overall and without their disease progressing. The trial investigators and other leading brain cancer researchers agreed that the results of the two trials will change the standard of care. from Ca... περισσότερα »
Curcumin: A new candidate for melanoma therapy?
Curcumin: A new candidate for melanoma therapy?: Abstract Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions are rare. Plants and plant extracts have long been used to treat a variety of human conditions; however, in many cases, effective doses of herbal remedies are associated with serious adverse effects. Curcumin is a natural polyphenol that shows a variety of pharmacological activities including anti-cancer effects, and only minimal adv... περισσότερα »
How Stressful Is “Deep Bubbling”?
Publication date: Available online 9 June 2016 *Source:*Journal of Voice Author(s): Jaana Tyrmi, Anne-Maria Laukkanen ObjectivesWater resistance therapy by phonating through a tube into the water is used to treat dysphonia. Deep submersion (≥10 cm in water, "deep bubbling") is used for hypofunctional voice disorders. Using it with caution is recommended to avoid vocal overloading. This experimental study aimed to investigate how strenuous "deep bubbling" is.Study DesignFourteen subjects, half of them with voice training, repeated the syllable [pa:] in comfortable speaking pitch and ... περισσότερα »
Anesthesia and Long-term Major Adverse Cognitive Effects: P-Values and Confidence Intervals Based on Nonrandom Samples Cannot Justify Acceptance of Null Hypotheses
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1XJEQWU from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UjQLYz via IFTTT
Journal Club
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1U9I8OX from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1tfhB9G via IFTTT
Effects of Fluid Treatment With Hydroxyethyl Starch on Renal Function in Patients With Aneurysmal Subarachnoid Hemorrhage
[image: image]Background: Recent reports have doubted the efficacy and safety of hydroxyethyl starch (HES) for volume resuscitation. HES has been reported to promote renal insufficiency particularly in sepsis and trauma patients. This analysis investigated the effects of HES 6% 130/0.4 for fluid therapy in patients with intact renal function who suffered aneurysmal subarachnoid hemorrhage (SAH). Methods: This retrospective analysis included 107 patients and was conducted in the framework of a clinical trial assessing the efficacy of magnesium sulfate in SAH. Because magnesium is ren... περισσότερα »
Spinal and Epidural Anesthesia in Patients With Recent Stable Fractures of Vertebral Column
[image: image]Background: The use of central neuraxial block (CNB) in patients with spinal injuries with or without spinal cord injury continues to be a contentious issue due to paucity of evidence supporting or refuting its use. There are only a few case reports reporting the use of the technique in these patients. We performed a retrospective record review of patients who underwent neuraxial blockade for lower limb orthopedic surgery in the presence of coexisting recent spine injury (defined as spine injury within 1 month) to assess the occurrence of postoperative deterioration of ... περισσότερα »
Morphine Preconditioning Downregulates MicroRNA-134 Expression Against Oxygen-Glucose Deprivation Injuries in Cultured Neurons of Mice
[image: image]Background: Brain protection by narcotics such as morphine is clinically relevant due to the extensive use of narcotics in the perioperative period. Morphine preconditioning induces neuroprotection in neurons, but it remains uncertain whether microRNA-134 (miR-134) is involved in morphine preconditioning against oxygen-glucose deprivation-induced injuries in primary cortical neurons of mice. The present study examined this issue. Materials and Methods: After cortical neurons of mice were cultured in vitro for 6 days, the neurons were transfected by respective virus vec... περισσότερα »
Αυτόματο προσχέδιο
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Recurrence of Oral Giant Pyogenic Granuloma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Correlation of Age, Sex, and Location With Recurrence of Oral Giant Pyogenic Granuloma After Surgical Excision.: Objectives: This study was carried out to correlate age and sex of the patient as well as location of the oral giant pyogenic granuloma (PG) with the recurrence rate after surgical excision. Methods: Seventy-two patients having oral giant PGs […]
Massive Subgaleal Haematoma Following Sudden Hair Pulling
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Hair Today; Scalped Tomorrow: Massive Subgaleal Haematoma Following Sudden Hair Pulling in an Adolescent in the Absence of Haematological Abnormality or Skull Fracture.: Subgaleal haematoma (SH) is a rare condition, most frequently observed in neonates as a complication of Ventouse-assisted delivery. There have been few patients reported beyond this period. Those that are present within […]
Use of Adipose-Derived Mesenchymal Stem Cells to Increase Viability of Composite Grafts.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Use of Adipose-Derived Mesenchymal Stem Cells to Increase Viability of Composite Grafts.: Objective: Chondrocutaneous composite grafts figure among the reconstruction alternatives for alar rim defects resulting from tumor resection and trauma. The major problem with composite grafts is the limited graft survival area. In the present study, the authors aimed to increase the survival area […]
Caudal Septal Support Versus Strut Graft in Achieving the Desired Lateral Profile in Rhinoplasty.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Caudal Septal Support Versus Strut Graft in Achieving the Desired Lateral Profile in Rhinoplasty.: Nasal tip support is critical to achieve a lasting result in rhinoplasty. In this article, the authors compared the effects of strut grafts (SG) and caudal septum-based nasal tip supporting techniques (CSB-T) in terms of reaching the desired tip projection. Included […]
Subjective tinnitus appears to be characterized by autoimmune and inflammatory events. Considering the decreasing MPV levels, MPV may be used to evaluate subjective tinnitus as an helper indicator.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Can Platelet Indices Be New Biomarkers for Subjective Tinnitus?.: Abstract Objectives: Mean platelet volume (MPV) is one of the platelet function indices that reflect the platelet production rate and functions. The MPV levels are increased by vascular occlusion, acute or chronic syndromes, and vasculitis, whereas infections, autoimmune diseases, and inflammatory situations reduce these levels. In […]
Gunshot-Inflicted Lower Face Defects
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Outcomes of Anatomic Reconstruction of Gunshot-Inflicted Lower Face Defects by Free Osteoseptocutaneous Fibula Flap and Expanded or Nonexpanded Temporal Scalp Flap Combination in Males.: Reconstruction of gunshot-inflicted composite lower face defects is a challenge for plastic surgeons. Functional and aesthetic repair of such defects mostly requires free or pedicled flap applications or combinations of both. […]
Deep Superior Sulcus Augmentation Using Acellular Human Dermal Matrix in Anophthalmic or Phthisis Socket.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Surgical Outcomes of Patients with anophthalmic or phthisis socket suffer from cosmetic problems. To resolve those problems, the authors present the surgical outcomes of deep superior sulcus (DSS) augmentation using acellular dermal matrix in patients with anophthalmic or phthisis socket. The authors retrospectively reviewed anophthalmic or phthisis patients who underwent surgery for DSS augmentation using […]
Intraoperative Pulsed Expansion of the Skin Using Silicone Urinary Catheter for the Placement of Osmotic Expander.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Intraoperative Pulsed Expansion of the Skin Using Silicone Urinary Catheter for the Placement of Osmotic Expander.: http://ift.tt/1XK2Uc7
Analysis of Surgical Outcome After Levator Advancement by Assessing Changes in Eyelid Contour.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Analysis of Surgical Outcome After Levator Advancement by Assessing Changes in Eyelid Contour.: Purpose: The authors analyzed changes in eyelid contour after levator advancement by measuring multiple radial midpupil lid distance (MPLD). Methods: The study enrolled 61 eyes of 61 patients with involutional ptosis who underwent levator advancement from 2 oculoplastic surgeons from September 2008 […]
Issue Information
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/1PNMnkx
New evidences on efficacy of boronic acid-based derivatization method to identify sugars in plant material by gas chromatography–mass spectrometry
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Marianna Faraco, Daniela Fico, Antonio Pennetta, Giuseppe E. De Benedetto This work presents an analytical procedure based on gas chromatography–mass spectrometry which allows the determination of aldoses (glucose, mannose, galactose, arabinose, xylose, fucose, rhamnose) and chetoses (fructose) in plant material.One peak for each target carbohydrate was obtained by using an efficient derivatization employing methylboronic acid and acetic anhydride sequentially, whereas the baseline separation of the analytes wa... περισσότερα »
Aptamer and PNIPAAm co-conjugated nanoparticles regulate activity of enzyme with different temperature
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Jiemiao Yu, Liangrong Yang, Xiangfeng Liang, Tingting Dong, Hongnan Qu, Meng Rong, Huizhou Liu In this paper, we described a temperature responsive nano-system that can regulate activity of enzyme with different temperature. Temperature responsive polymer poly(N-isopropylacrylamide) (PNIPAAm), with low critical solution temperature of 32°C, was synthesized with thiol modification. PNIPAAm and thrombin aptamer were co-functionalized on the surface of gold nanoparticles for effective regulation of thrombin activi... περισσότερα »
Simultaneous determination of radiocesium (135Cs, 137Cs) and plutonium (239Pu, 240Pu) isotopes in river suspended particles by ICP-MS/MS and SF-ICP-MS
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Liguo Cao, Jian Zheng, Hirofumi Tsukada, Shaoming Pan, Zhongtang Wang, Keiko Tagami, Shigeo Uchida Due to radioisotope releases in the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident, long-term monitoring of radiocesium (135Cs and 137Cs) and Pu isotopes (239Pu and 240Pu) in river suspended particles is necessary to study the transport and fate of these long-lived radioisotopes in the land-ocean system. However, it is expensive and technically difficult to collect samples of suspended particles from rive... περισσότερα »
Purification of quantum dot-based bioprobes via high-performance size exclusion chromatography
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Jia-Kai Wu, Zhi-Quan Tian, Zhi-Ling Zhang, An-An Liu, Bo Tang, Li-Juan Zhang, Zhi-Liang Chen, Dai-Wen Pang Due to excellent optical properties, quantum dots (QDs) have been widely applied to sensing, labeling, and imaging. For the fabrication of QD-based bioprobes, purification is usually the crucial step. Hydrophilic octylamine grafted polyacrylic acid modified QDs (OPA-QDs) were prepared, and purified by high-performance size exclusion chromatography (HPSEC) to remove excess OPA and aggregated QDs. The percen... περισσότερα »
Scaling of GFR and SUV for body size: the curious conflict of whole body metric preferences
from #Medicine via ola Kala on Inoreader http://ift.tt/1UqcvOj via IFTTT
Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development
Tissue Engineering Part A Jun 2016, Vol. 22, No. 11-12: 885-898. from #Medicine via ola Kala on Inoreader http://ift.tt/1rfJOMy via IFTTT
Purinergic Signaling Regulates the Transforming Growth Factor-β3-Induced Chondrogenic Response of Mesenchymal Stem Cells to Hydrostatic Pressure
Tissue Engineering Part A Jun 2016, Vol. 22, No. 11-12: 831-839. from #Medicine via ola Kala on Inoreader http://ift.tt/1XJQT6D via IFTTT
Expandable Scaffold Improves Integration of Tissue-Engineered Cartilage: An In Vivo Study in a Rabbit Model
Tissue Engineering Part A Jun 2016, Vol. 22, No. 11-12: 873-884. from #Medicine via ola Kala on Inoreader http://ift.tt/1rfKilO via IFTTT
Effects of Composition and Mechanical Property of Injectable Collagen I/II Composite Hydrogels on Chondrocyte Behaviors
Tissue Engineering Part A Jun 2016, Vol. 22, No. 11-12: 899-906. from #Medicine via ola Kala on Inoreader http://ift.tt/1OfER1r via IFTTT
Cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
8h Idelalisib for relapsed/refractory indolent B-cell non-Hodgkin’s lymphoma: an overview of pharmacokinetics and clinical trial outcomes. Related ArticlesIdelalisib for relapsed/refractory indolent B-cell non-Hodgkin’s lymphoma: an overview of pharmacokinetics and clinical trial outcomes. Expert Rev Hematol. 2015 Oct;8(5):581-93 Authors: Davies A Abstract Indolent non-Hodgkin’s lymphoma… 8h Technique for CT Fluoroscopy-Guided Lumbar Medial Branch Blocks and […]
Melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
21m Does PET SUV harmonization impact PERCIST response classification? Does PET SUV harmonization impact PERCIST response classification?: Pre- and post-treatment positron emission tomography (PET) comparative scans should ideally be performed with identical acquisition and processing but this is often impractical. The degree to which differing protocols impact PET Evaluation… 2h Curcumin: A new candidate […]
Allergy and Immunology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
3h Viral vectors as vaccine platforms: from immunogenicity to impact Katie J Ewer | Teresa Lambe | Christine S Rollier | Alexandra J Spencer | Adrian VS Hill | Lucy Dorrell from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1Ydjpfp via IFTTT 7h Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract Publication […]
Squamous cell carcinomas
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
44m The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT 1h The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current […]
OtoRhinoLaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
9h OtoRhinoLaryngology – Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader A rare cause of odynophagia: infected tracheal diverticulum. Related Articles A rare cause of odynophagia: infected tracheal diverticulum. Kulak Burun Bogaz Ihtis Derg. 2015;25(2):126-30 Authors: Şahin N, Solak A, Genç B Abstract Tracheal diverticulum is a relatively rare lesion. Tracheal diverticula are divided […]
Postexposure management of occupational injuries amongst health care workers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Divya Deodhar, Jency Maria Koshy, Mary John CHRISMED Journal of Health and Research 2016 3(3):151-154 Occupational exposure comprises of needle stick injury (NSI) and mucosal splashes. A health care worker (HCW) is at a greater risk of developing blood borne virus infection while at work. Due to high prevalence of human immunodeficiency virus, hepatitis B […]
Client’s satisfaction with the health services under Janani Suraksha Yojana in rural area of Himachal Pradesh
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Prem Lal Chauhan, DS Dhadwal, Anjali Mahajan CHRISMED Journal of Health and Research 2016 3(3):187-190 Background: Satisfaction can be defined as the extent of an individual’s experience compared with his or her expectations. Client satisfaction is one of the commonly used outcome measures of patient care and is an important indicator of quality of primary […]
Mysterious inguinal swellings disguised as hernia: Series of four cases
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
DS Nirhale, VS Athavale, Mohit Bhatia, Vishal Tomar CHRISMED Journal of Health and Research 2016 3(3):218-222 A hernia surgeon may encounter unexpected intraoperative findings. It is important to be prepared to detect them and apply the appropriate treatment. We retrospectively studied twenty patients with inguinal swellings who were admitted to our surgical department over a […]
A study of prescribing pattern, comorbidities, and cost analysis in elderly hospitalized patients in Pune
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Asawari Raut, Faizal Vohra, Rahul Surve, Atmaram Pawar CHRISMED Journal of Health and Research 2016 3(3):191-196 Aim: To study prescribing pattern, comorbidities, and cost analysis in elderly hospitalized patients. Materials and Methods: A prospective, observational study was conducted to assess the prescribing pattern, drug utilization, and cost analysis in elderly patients at a tertiary care […]
A rare case of branch retinal vein occlusion following Sirsasana
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Anugraha Balamurugan, Krishnagopal Srikanth International Journal of Yoga 2016 9(2):173-175 Sirsasana is a type of headstand postural yoga in which the body is completely inverted. It is performed with or without wall support. In this position, the body is held upright supported by the forearms, while the crown of the head rests lightly on the […]
Yoga protocol for treatment of breast cancer-related lymphedema
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
SR Narahari, Madhur Guruprasad Aggithaya, Liselotte Thernoe, Kuthaje S Bose, Terence J Ryan International Journal of Yoga 2016 9(2):145-155 Introduction: Vaqas and Ryan (2003) advocated yoga and breathing exercises for lymphedema. Narahari et al. (2007) developed an integrative medicine protocol for lower-limb lymphedema using yoga. Studies have hypothesized that yoga plays a similar role as […]
Living your yoga
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Karuna Nagarajan International Journal of Yoga 2016 9(2):178-179 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PNmFfZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Ag/Ag 2 SO 3 plasmonic catalysts with high activity and stability for CO 2 reduction with water vapor under visible light
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The conversion of CO2 into useful raw materials for fuels and chemicals by solar energy is described using a plasmonic photocatalyst comprised of Ag supported on Ag2SO3 (Ag/Ag2SO3) fabricated by a facile solid-state ion-exchange method and subsequent reduction with hydrazine hydrate. The optimum molar ratio of Ag0/Ag+ was 5 %. Visible light irradiation (>400 […]
E ffects of γ-Fe 2 O 3 nanoparticles on the survival and reproduction of Biomphalaria glabrata (Say, 1818) and their elimination from this benthic aquatic snail
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract This study aims to evaluate the effects of maghemite nanoparticles (γ-Fe2O3) coated with meso-2, 3-dimercaptosuccinic acid (DMSA) stabilizer on the survival and reproduction of the aquatic snail Biomphalaria glabrata. The cumulative means of egg masses and eggs per individual in the control group at the end of 4 weeks were 18.8 and 326.7, respectively. […]
Response of leaf and fine roots proteomes of Salix viminalis L. to growth on Cr-rich tannery waste
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The tannery industry is a major source of anthropogenic chromium (Cr) contamination due to the large amounts of solid waste produced and its problematic management. The unique composition of tannery waste, usually high concentrations of Cr and other metals as well as organic matter and nutrients, makes it a great risk for soil and […]
Anesthesia and Long-term Major Adverse Cognitive Effects: P-Values and Confidence Intervals Based on Nonrandom Samples Cannot Justify Acceptance of Null Hypotheses
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1XJEQWU
Journal Club
No abstract available from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1U9I8OX
High-resolution colonic motility recordings in vivo compared with ex vivo recordings after colectomy, in patients with slow transit constipation
Abstract Background The pathogenesis of slow transit constipation (STC) remains poorly understood, with intrinsic and extrinsic abnormalities implicated. Here, we present high-resolution colonic manometry recordings from four STC patients recorded before total colectomy, and subsequently, *ex vivo*, after excision. Methods In four female, treatment-resistant STC patients (median age 35.5 years), a fiber-optic manometry catheter (72 sensors spaced at 1 cm intervals) was placed with the aid of a colonoscope, to the mid-transverse colon. Colonic manometry was recorded 2 h before and a... περισσότερα »
Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis
Abstract Background Therapeutic options for management of diabetic gastroparesis are limited. Failure to maintain upregulation of heme oxygenase (HO1) leads to loss of interstitial cells of Cajal and delayed gastric emptying (GE) in non-obese diabetic mice. Our hypothesis was that hemin upregulation of HO1 would restore normal GE in humans with gastroparesis. Aims To compare effects of hemin and placebo infusions on HO1 activity and protein, GE, autonomic function, and gastrointestinal symptoms in diabetic gastroparesis. Methods In a single-center, double-blind, placebo-controlled,... περισσότερα »
Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers
Abstract Background Synthetic human ghrelin accelerates gastric emptying, reduces gastric accommodation, and results in numerical increases in postprandial symptom scores. The ghrelin receptor agonist, relamorelin, accelerates gastric emptying in patients with diabetic gastroparesis. Aim To measure pharmacological effects of relamorelin on gastric accommodation, distal antral motility, and satiation in healthy volunteers. Methods In a placebo-controlled, double-blind, randomized study of 16 healthy volunteers, we compared effects of 30 *μ*g subcutaneous (s.c.) relamorelin to placeb... περισσότερα »
How Stressful Is “Deep Bubbling”?
Publication date: Available online 9 June 2016 *Source:*Journal of Voice Author(s): Jaana Tyrmi, Anne-Maria Laukkanen ObjectivesWater resistance therapy by phonating through a tube into the water is used to treat dysphonia. Deep submersion (≥10 cm in water, “deep bubbling”) is used for hypofunctional voice disorders. Using it with caution is recommended to avoid vocal overloading. This experimental study aimed to investigate how strenuous “deep bubbling” is.Study DesignFourteen subjects, half of them with voice training, repeated the syllable [pa:] in comfortable speaking pitch and lo... περισσότερα »
Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation
AbstractObjective Intestinal intraepithelial lymphocytes (IELs) play critical roles in disrupting epithelial homeostasis after Toll-like receptor (TLR)-3 activation with genomic rotavirus dsRNA or the synthetic dsRNA analog poly(I:C). The capacity of immunobiotic *Lactobacillus rhamnosus* CRL1505 (Lr1505) or *Lactobacillus plantarum* CRL1506 (Lp1506) to beneficially modulate IELs response after TLR3 activation was investigated in vivo using a mice model. Results Intraperitoneal administration of poly(I:C) induced inflammatory-mediated intestinal tissue damage through the increase o... περισσότερα »
How Stressful Is “Deep Bubbling”?
Publication date: Available online 9 June 2016 *Source:*Journal of Voice Author(s): Jaana Tyrmi, Anne-Maria Laukkanen ObjectivesWater resistance therapy by phonating through a tube into the water is used to treat dysphonia. Deep submersion (≥10 cm in water, “deep bubbling”) is used for hypofunctional voice disorders. Using it with caution is recommended to avoid vocal overloading. This experimental study aimed to investigate how strenuous “deep bubbling” is.Study DesignFourteen subjects, half of them with voice training, repeated the syllable [pa:] in comfortable speaking pitch and lo... περισσότερα »
Increased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 93-100. from #Medicine via ola Kala on Inoreader http://ift.tt/1XdhrMy via IFTTT
Fatigue and Exhaustion in Hypoxia: The Role of Cerebral Oxygenation
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 72-84. from #Medicine via ola Kala on Inoreader http://ift.tt/1tfsybw via IFTTT
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 57-60.
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 57-60. from #Medicine via ola Kala on Inoreader http://ift.tt/1XdhvvZ via IFTTT
Muscarinic Receptor Activation Affects Pulmonary Artery Contractility in Sheep: The Impact of Maturation and Chronic Hypoxia on Endothelium-Dependent and Endothelium-Independent Function
High Altitude Medicine & Biology Jun 2016, Vol. 17, No. 2: 122-132. from #Medicine via ola Kala on Inoreader http://ift.tt/1tfsBnC via IFTTT
