Dynamic RSA: Examining parasympathetic regulatory dynamics via vector-autoregressive modeling of time-varying RSA and heart period
Abstract Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration rate via vector autoregression. Moreover, we modeled these relationships at lags of 1 s to 10 s, in order to evaluate the optimal latency for estimating dynamic RSA effe... περισσότερα »
Dynamic RSA: Examining parasympathetic regulatory dynamics via vector-autoregressive modeling of time-varying RSA and heart period
Abstract Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration rate via vector autoregression. Moreover, we modeled these relationships at lags of 1 s to 10 s, in order to evaluate the optimal latency for estimating dynamic RSA eff... περισσότερα »
Molecular mechanism of regulation of MTA1 by Granulocyte Colony Stimulating Factor Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Parkinson’s disease (PD) is a neurodegenerative disorder with loss of dopaminergic neurons of the brain, which results in insufficient synthesis and action of dopamine. Metastasis associated protein 1 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), rate limiting enzyme in dopamine (DA) synthesis and hence MTA1 plays a significant role in PD pathogenesis. To […]
Rab13 and the Regulation of Cancer Cell Behavior Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
The Rab family of GTPases are master regulators of cellular membrane trafficking. With approximately 70 members in humans, Rabs have been implicated in all steps of membrane trafficking ranging from vesicle formation and transport to vesicle docking/tethering and fusion. Vesicle trafficking controls the localization and levels of a myriad of proteins, thus regulating cellular functions […]
PLEKHA7 recruits PDZD11 to adherens junctions to stabilize nectins Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
PLEKHA7 is a junctional protein implicated in stabilization of the cadherin protein complex, hypertension, cardiac contractility, glaucoma, microRNA processing, and susceptibility to bacterial toxins. To gain insight into the molecular basis for the functions of PLEKHA7, we looked for new PLEKHA7 interactors. Here we report the identification of PDZ domain-containing protein 11 (PDZD11) as a […]
Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1 Molecular Biophysics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Glutamate transporters actively take up glutamate into the cell, driven by the co-transport of sodium ions down their transmembrane concentration gradient. It was proposed that glutamate binds to its binding site and is subsequently transported across the membrane in the negatively charged form. With the glutamate binding site being located partially within the membrane domain, […]
Phosphorylation of Yeast Pah1 Phosphatidate Phosphatase by Casein Kinase II Regulates Its Function in Lipid Metabolism Lipids
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Pah1 phosphatidate phosphatase in Saccharomyces cerevisiae catalyzes the penultimate step in the synthesis of triacylglycerol, i.e., the production of diacylglycerol by dephosphorylation of phosphatidate. The enzyme playing a major role in lipid metabolism is subject to phosphorylation (e.g., by Pho85-Pho80, Cdc28-cyclin B, protein kinases A and C) and dephosphorylation (e.g., by Nem1-Spo7) that regulate its […]
Smartphone Pain App for Assessing Oral Mucositis Pain in Patients Receiving Head and Neck Radiation Therapy
Smartphone Pain App for Assessing Oral Mucositis Pain in Patients Receiving Head and Neck Radiation Therapy: *Condition*: Oral Mucositis *Intervention*: Other: OM Pain App *Sponsor*: Stuart Wong ArmsAssigned Interventions Experimental: OM Pain Smartphone Application This study examines whether the smartphone OM Pain App is a feasible and valid tool to assess pain from radiation-induced oral mucositis. Other: OM Pain App Each study participant will be issued an Android smartphone, or he or she may use his/her own compatible device (whether or not it has an active data service)... περισσότερα »
Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma
Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma: Abstract Background Renal function influences decisions regarding treatment for patients with oropharyngeal squamous cell carcinoma (SCC). However, the importance of renal function in oropharyngeal SCC has not yet been reported. Methods Four hundred sixty patients with oropharyngeal SCC treated with curative intent between April 2005 and March 2007 in 12 institutions in Japan were analyzed retrospectively. Results Four hundred three patients (87.6%) showed a creatinine clearance (CrCl)...περισσότερα »
Prognostic value of midtreatment FDG-PET in oropharyngeal cancer
Prognostic value of midtreatment FDG-PET in oropharyngeal cancer: Abstract Background Prognostic metabolic imaging indices are needed for risk stratification for patients with locally advanced oropharyngeal cancer. Methods We retrospectively examined pretreatment and midtreatment fluorodeoxyglucose-positron emission tomography (FDG-PET) parameters in patients with locally advanced oropharyngeal cancer who were treated with definitive chemoradiation. Results A total of 74 patients were evaluated. Pretreatment metabolic tumor volume (MTV) using threshold of 50% standardized uptake valu... περισσότερα »
Cutaneous squamous cell carcinoma with perineural spread
Insight into the epidemiology of [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] ABSTRACT Background Perineural spread (PNS) of cutaneous squamous cell carcinoma of the head and neck (SCCHN) can be associated with poor outcomes. Disease understanding and awareness is limited leading to delayed diagnosis and treatment. The purpose of this study was to identify epidemiological features of patients with PNS of cutaneous SCCHN. Methods Tumor characteristics and demographics of patients with PNS of cutaneous SCCHN managed through a single institution were collected between 1998 and ... περισσότερα »
Recurrent or residual nasopharyngeal cancer after definitive treatment:
Relapse status as a prognostic factor in patients receiving salvage surgery for [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background The purpose of this study was to determine the prognostic value of relapse status (recurrent vs residual disease) in patients receiving surgical salvage for nasopharyngeal carcinoma (NPC). Methods Retrospective review was conducted on 52 patients who underwent salvage surgery for locoregional relapse of NPC. Univariate and multivariate analyses were used to investigate the prognostic value of relapse status. Results Median follow-up... περισσότερα »
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx
using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background The use of lymphatic vessel density as a predictor of occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported. Methods Staining of the specific lymphatic endothelial cells nuclear marker, PROX1, as an indicator of lymphatic vessel density was determined by counting the number of positive cells in squamous cell carcinomas (SCCs) of the oral cavity and the oropharynx with clinical... περισσότερα »
Surgical margins in head and neck squamous cell carcinoma
: Effect of heat artifact on immunohistochemistry as a future tool for assessment: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] ABSTRACT Background Margins in head and neck squamous cell carcinoma (HNSCC) are determined by morphological changes assessed via hematoxylin-eosin staining. Physiological changes may not be detected by this technique. The purpose of this study was to determine if a protein biomarker, laminin-332γ2, overexpressed in cancer cells at the invasive front in HNSCC, remains unaffected by heat produced during resection, supporting a role for immunohistoc... περισσότερα »
The therapeutic effects of total laryngectomy and a larynx-preservation approach in patients with T4a laryngeal cancer and thyroid cartilage invasion
: A multicenter retrospective review: ABSTRACT Background In T4a laryngeal cancer with thyroid cartilage invasion, no optimal frontline treatment has yet been defined in controlled trials. Methods We reviewed data from 89 patients with T4a laryngeal cancer featuring thyroid cartilage invasion who were treated initially with either total laryngectomy (*n* = 53) or a larynx-preservation strategy (*n* = 36). Results The median progression-free survival (PFS) of the total laryngectomy group had not been attained at the time of analysis and was thus significantly longer than that of the l... περισσότερα »
Tobacco and alcohol consumption after total laryngectomy and survival
multicenter prospective cohort study: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background We examined the relation of tobacco and alcohol consumption after total laryngectomy with overall survival (OS). Methods Tobacco and alcohol consumption was assessed at 5 time points after total laryngectomy. Patients were followed up for survival until December 31, 2014. A multivariate Cox regression was fitted to test for differences in OS. Results Three hundred fifty-nine patients were included in this study. Compared to former smokers, never smokers had hazard ratios (...περισσότερα »
Localized sinonasal mucosal melanoma
: Outcomes and associations with stage, radiotherapy, and positron emission tomography response: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Sinonasal mucosal melanoma is a rare neoplasm with a poor prognosis. Methods Retrospective analysis was conducted on 78 patients with localized sinonasal mucosal melanoma treated at Memorial Sloan Kettering Cancer Center (MSKCC from 1998–2013). Demographic, tumor, imaging, and treatment factors were recorded and survival and disease-control outcomes were analyzed. Results Median overall survival (OS) and disease-spe...περισσότερα »
Head and neck chondrosarcomas
: Analysis of the Surveillance, Epidemiology, and End Results database: ABSTRACT Background Chondrosarcoma is a rare tumor of the head and neck. Because of the limited clinical data, no studies have conducted a thorough comparison between head and neck chondrosarcomas and those arising at other body sites. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared 682 patients with chondrosarcomas of the head and neck with 4757 patients with non–head and neck chondrosarcomas, evaluating disease-specific survival (DSS) and overall survival (OS) based on... περισσότερα »
Transoral laser microsurgery for oropharyngeal squamous cell carcinoma
: A paradigm shift in therapeutic approach: Abstract Background The contemporary treatment of oropharyngeal squamous cell carcinoma (SCC) is an area of debate. We report outcomes of a minimally invasive approach involving transoral laser microsurgery (TLM). Methods A consecutive series of patients (*n* = 153) undergoing primary TLM for oropharyngeal SCC from 2006 to 2013 was studied. Human papillomavirus (HPV) status was determined by p16 immunohistochemistry and high-risk HPV DNA in situ hybridization. Survival analyses were evaluated using Kaplan–Meier statistics. Results Tumor su... περισσότερα »
Magnetic resonance venogram (MRV).The underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation
Diplopia as a sequel of unilateral neck dissection: Abstract Background The purpose of this study was to discuss the underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation. In addition, the management protocol for such rare cases has been discussed along with literature review. Methods PubMed and Google were used to search the literature for cases of raised intracranial pressure with complications after unilateral internal jugular vein (IJV) ligation. Twelve case reports with 17 patients were identified. Results There were 1... περισσότερα »
Diplopia as a sequel of unilateral neck dissection
Diplopia as a sequel of unilateral neck dissection: Abstract Background The purpose of this study was to discuss the underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation. In addition, the management protocol for such rare cases has been discussed along with literature review. Methods PubMed and Google were used to search the literature for cases of raised intracranial pressure with complications after unilateral internal jugular vein (IJV) ligation. Twelve case reports with 17 patients were identified. Results There were 1... περισσότερα »
Clinical and morphological aspects of adenocarcinomas of the intestinal type in the inner nose
: a retrospective multicenter analysis: AbstractClinical and histological parameters from 117 patients with wood dust-related sinonasal adenocarcinomas of intestinal type (ITAC) were analyzed and correlated with a follow-up period of 5 years at least. The rate of survival for 5 years was 53.1 % and for 10 years 30.2 %. Only 33 patients were free of disease. 74.2 % of patients with recurrences died in relation to ITAC. As expected, tumors of T4-category had the worst prognosis. The mucus content of a tumor was the most important histological parameter. Endonasal methods of surgery h... περισσότερα »
Initial severity of motor and non-motor disabilities in patients with facial palsy
: an assessment using patient-reported outcome measures: AbstractPatients with facial palsy (FP) not only suffer from their facial movement disorder, but also from social and psychological disabilities. These can be assessed by patient-reported outcome measures (PROMs) like the quality-of-life Short-Form 36 Item Questionnaire (SF36) or FP-specific instruments like the Facial Clinimetric Evaluation Scale (FaCE) or the Facial Disability Index (FDI). Not much is known about factors influencing PROMs in patients with FP. We identified predictors for baseline SF36, FaCE, and FDI scoring... περισσότερα »
Treatment Strategies for Smell Loss
Treatment Strategies for Smell Loss: AbstractSmell loss is a widespread problem with approximated levels of about 5 % of the population exhibiting functional anosmia. Olfactory problems lead to a loss of quality of life. The objectives of this manuscript were to identify recent findings concerning the treatment of smell loss. We focused on the treatment of causes of smell loss, generally excluding sinonasal disease, as treatment of this form of smell loss has previously been frequently analysed. Treatment suggestions ranged from olfactory training to the administration of various d... περισσότερα »
Routine peri-operative pediatric tracheotomy care
: consensus recommendations via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 4 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Julie E. Strychowsky, David Albert, Kenny Chan, Alan Cheng, Sam Daniel, Alessandro De Alarcon, Noel Garabedian, Catherine Hart, Christopher Hartnick, Andy Inglis, Ian Jacobs, Monica Kleinman, Nilesh Mehta, Richard Nicollas, Roger Nuss, Seth Pransky, John Russell, Mike Rutter, Anne Schilder, Dana Thompson, Jean-Michel Triglia, Mark Volk, Bob Ward, Karen Watters, Michelle Wyatt, Ge...περισσότερα »
Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique
Radiologic Evidence of To compare the thicknesses of bone beneath the internal receiver stimulator (IRS) with the symmetric contralateral unimplanted side in postoperative temporal high-resolution computed tomography (CT) and/or cranial CT of the patients for whom cochlear implants were secured by the subperiosteal temporal pocket technique. Study Design Case series with chart review. Setting Tertiary care hospital, cochlear implant referral center. Subjects Cochlear-implanted pediatric patients with postoperative temporal high-resolution CT and/or cranial CT were reviewed. T...περισσότερα »
Occurrence of ochratoxin A in spices commercialized in Abidjan (Côte d’Ivoire)
Abstract Ochratoxin A (OTA) is a mycotoxin produced mostly by several species of *Aspergillus* and *Penicillium*. OTA is nephrotoxic in all animal species in which it has been tested and is cancerogenic in rodents. It is associated with Balkan endemic nephropathy. It is naturally present in many crop products such as cereals (barley, wheat, maize) and dried fruits, spices, coffee, wine, olives, and cocoa. The aim of this study was to assess the contamination of three Ivoirian spices with OTA (ginger, chili, and pepper) widely consumed by the population. A total of 90 spice samples ... περισσότερα »
An in vitro study of alkaline phosphatase sensitivity to mixture of aflatoxin B 1 and fumonisin B 1 in the hepatopancreas of coastal lagoon wild and farmed shrimp Litopenaeus vannamei
Abstract This study aimed to establish the combined effect of aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on wild *Litopenaeus vannamei* hepatopancreas alkaline phosphatase (AP) activity compared with that of farmed shrimp. AP activity in hepatopancreas extract was confirmed by several specific inhibitor assays. AP activity of wild shrimp was higher than that of farmed shrimp (*p* < 0.05). However, AP activity from both wild and farmed shrimp was inhibited when incubated with AFB1 and FB1. The greatest inhibition occurred when AP was incubated with a mixture of AFB1 and FB1. The IC5... περισσότερα »
An in vitro study of alkaline phosphatase sensitivity to mixture of aflatoxin B 1 and fumonisin B 1 in the hepatopancreas of coastal lagoon wild and farmed shrimp Litopenaeus vannamei
Abstract This study aimed to establish the combined effect of aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on wild *Litopenaeus vannamei* hepatopancreas alkaline phosphatase (AP) activity compared with that of farmed shrimp. AP activity in hepatopancreas extract was confirmed by several specific inhibitor assays. AP activity of wild shrimp was higher than that of farmed shrimp (*p* < 0.05). However, AP activity from both wild and farmed shrimp was inhibited when incubated with AFB1 and FB1. The greatest inhibition occurred when AP was incubated with a mixture of AFB1 and FB1. The IC5... περισσότερα »
The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss
: Possible Prognostic Factors of Response to Corticosteroid Treatment: *Introduction:* Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune response in the inner ear resulting in ISSNHL. Proinflammatory cytokines play a central role in this cochlear immunological cascade. *Objective:* To examine the expression of proinflammatory cytokines in the serum of patients with ISSNHL in correlation with the... περισσότερα »
Tonsillectomy or Adenotonsillectomy versus Non-Surgical Management for Obstructive Sleep-Disordered Breathing in Children
Cochrane Corner: Extracts from The Cochrane Library: The "Cochrane Corner" is a section in the journal that highlights systematic reviews relevant to otolaryngology–head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review on tonsillectomy for obstructive sleep-disordered breathing (oSDB) in children, which finds moderate-quality evidence that surgery improves symptoms, behavior, and quality of life compared to nonsurgical management. The results apply to nonsyndromic children with SDB confirmed by polysomnography ...περισσότερα »
Cochlear Implantation in Children and Adults
Systematic Review on Surgical Outcomes and Hearing Preservation for The mastoidectomy with facial recess approach (MFRA) is considered the reference standard for cochlear implantation. The suprameatal approach (SMA) was developed more recently and does not require mastoidectomy, which could influence postoperative outcomes. We aim to identify the optimal operative approach for cochlear implantation based on postoperative complications and hearing preservation in children and adults. Data Sources PubMed, EMBASE, Scopus, and Google Scholar. Review Methods Studies comparing MFRA a... περισσότερα »
Biomaterials
in Rhinology: Introduction Many different kinds of rhinologic biomaterials, both nonabsorbable and absorbable, have been developed over the years to improve outcomes following endoscopic sinus surgery (ESS) for patients with chronic rhinosinusitis. In particular, these products have been designed to prevent postoperative bleeding, optimize the wound healing process, and reduce inflammation. This review evaluates the most recent evidence on biomaterials used in rhinology, focusing on these outcomes after ESS. Data Sources MEDLINE, Scopus, Google Scholar, and Clinicaltrials.gov. Re...περισσότερα »
Head and Neck Paragangliomas
: An Update on Evaluation and Management: Objective Head and neck paragangliomas are a group of slow-growing hypervascular tumors associated with the paraganglion system. The approach to evaluate and treat these lesions has evolved over the last 2 decades. While radical surgery had been the traditional approach, improvements in diagnostic imaging as well as radiation therapy techniques have led to an emphasis on observation and nonsurgical therapy in many patients. This article reviews the contemporary approach to the workup and management of head and neck paragangliomas. Data Sour... περισσότερα »
Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine
Variable Findings for : Objective To compare VOTE classification findings (velum, oropharyngeal-lateral walls, tongue base, and epiglottis) for drug-induced sleep endoscopy (DISE) among patients with obstructive sleep apnea (OSA) using 2 sedation protocols. Study Design Case series with chart review. Setting Single tertiary institution. Subjects Patients with OSA who underwent DISE. Methods A total of 216 patients underwent DISE between November 23, 2011, and May 1, 2015. DISE findings based on VOTE classification were compared between patients receiving the propofol- and de... περισσότερα »
Acute Invasive Fungal Rhinosinusitis
: A 15-Year Experience with 41 Patients: Objectives To describe a 15-year single-institution experience of 41 cases of acute invasive fungal sinusitis (AIFRS), identify clinical indicators predictive of AIFRS, and discuss our approach to these high-acuity patients. Study Design Case series with chart review. Setting Tertiary referral center; The Pennsylvania State University Hershey Medical Center. Subjects and Methods A retrospective review was performed for AIFRS consultations between September 1999 and March 2014. Variables reviewed included underlying condition, presenting s... περισσότερα »
Balloon Sinus Procedures
An Analysis of Adverse Event Reporting in Balloon Sinus Procedures: Objective (1) Become familiar with reported adverse events related to balloon dilation of the paranasal sinus ostia. (2) Understand the sequelae occurring with these events. Study Design Retrospective analysis of a prospective database. Setting OpenFDA database. Subjects and Methods The OpenFDA program website of the Food and Drug Administration was queried with the Application Program Interface query system for medical device adverse events involving balloon devices for the dilation of paranasal sinus ostia f... περισσότερα »
Effect of Radiofrequency Thermal Ablation Treatment on Nasal Ciliary Motility
: A Study with Phase-Contrast Microscopy: Objective To investigate the efficacy of nasal ciliary motility after radiofrequency ablation treatment in patients with isolated inferior turbinate hypertrophy and to clarify how long until normal ciliary function is restored. Study Design Prospective, single-group, pretest-posttest design. Setting Academic tertiary care medical center. Subjects and Methods This study involved 34 adult patients affected by nasal obstruction due to inferior turbinate hypertrophy who underwent radiofrequency ablation treatment between June and December 201... περισσότερα »
Usage of different types of pharyngeal packing did not affect incidence of PONV and throat pain, nor did usage of no packing
Does Type of Pharyngeal Packing during Sinonasal Surgery Have an Effect on PONV and Throat Pain?: Objective Postoperative nausea and vomiting (PONV) is a common problem that affects up to 30% of all surgical patients after general anaesthesia, which increases in sinonasal surgery due the very potent emetic effect of ingested blood that is swallowed during the procedures. Therefore, a hypo/oropharyngeal packing is commonly placed in an effort to prevent blood ingestion. The primary aim of this study was to compare the efficacy of 3 packing types in preventing PONV and to compare the ...περισσότερα »
Tracheostomy Complications
in Institutionalized Children with Long-term Tracheostomy and Ventilator Dependence: Objectives (1) To identify tracheostomy complications in institutionalized children with chronic tracheostomy. (2) To determine factors that predispose to development of tracheostomy complications in institutionalized children with chronic tracheostomy. Study Design Case series with chart review over 10 years. Setting Tertiary children’s hospital. Subjects and Methods Children were included if they underwent tracheostomy before 21 years of age and resided at a pediatric nursing facility. Most c... περισσότερα »
Application of Lean Sigma to the Audiology Clinic
at a Large Academic Center: Objective To apply Lean Sigma—a quality improvement strategy to eliminate waste and reduce variation and defects—to improve audiology scheduling and utilization in a large tertiary care referral center. The project goals included an increase in utilization rates of audiology block time and a reduction in appointment lead time. Study Design Prospective quality improvement study. Setting Academic tertiary care center. Subjects All patients scheduling audiology clinic visits July 2013 to July 2014. Methods Value stream mapping was performed for the aud... περισσότερα »
A Pediatric Decannulation Protocol
: Outcomes of a 10-Year Experience: Objectives (1) Describe an institutional protocol that focuses on the essential steps for decannulation of pediatric patients with long-term tracheostomies. (2) Discuss the preliminary observations of the safety of this protocol in regard to decannulation failures and successes in a selected patient population. Study Design Case series with chart review. Setting A tertiary pediatric hospital. Subjects Subjects were pediatric patients with chronic tracheostomies undergoing decannulation. Ages ranged from 1 to 17 years old. Indications for initi... περισσότερα »
Implementation of a Pediatric Posttonsillectomy Pain Protocol
in a Large Group Practice: Objective In response to the increased risk of respiratory failure and death after tonsillectomy related to codeine use, Kaiser Permanente Northwest restricted use of opioids in patients <7 years old via electronic health record (EHR). However, opioids could be prescribed at physician discretion by overriding the EHR. This study aims to examine protocol compliance in a large group practice using EHR order sets and complication rates as compared with historical data. Study Design Case series with chart review. Setting Ambulatory care within a health mai... περισσότερα »
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique: Objective To compare the thicknesses of bone beneath the internal receiver stimulator (IRS) with the symmetric contralateral unimplanted side in postoperative temporal high-resolution computed tomography (CT) and/or cranial CT of the patients for whom cochlear implants were secured by the subperiosteal […]
Lärmschwerhörigkeit
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
(BK-Nr. 2301) – Eine retrospektive Analyse von 100 konsekutiven Fällen: Laryngo-Rhino-Otol DOI: 10.1055/s-0042-102456 Einleitung: Bei der Begutachtung einer Lärmschwerhörigkeit als Berufskrankheit nach Nr. 2301 muss überprüft werden, ob die berufliche Lärmexposition die wesentliche Ursache für die Schwerhörigkeit darstellt. Mit dieser Arbeit sollte die Gruppe der zu Begutachtenden, bei der die Voraussetzungen für eine BK-Nr. 2301 […]
Element-wise uniqueness, prior knowledge, and data-dependent resolution
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Techniques for finding regularized solutions to underdetermined linear systems can be viewed as imposing prior knowledge on the unknown vector. The success of modern techniques, which can impose priors such as sparsity and non-negativity, is the result of advances in optimization algorithms to solve problems which lack closed-form solutions. Techniques for characterization and analysis […]
Multiple access interference in MIMO-CDMA systems under Rayleigh fading: statistical characterization and applications
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
A major limiting factor in the performance of multiple-input-multiple-output (MIMO) code division multiple access (CDMA) systems is multiple access interference (MAI) which can reduce the system’s capacity and… from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1qqJBGm via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RVoJQw via IFTTT
Focusing on the delayed complications of fusing occipital squama to cervical spine for stabilization of congenital atlantoaxial dislocation and basilar invagination
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 4 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): Pravin Salunke, Sushant, Sood Sudhir, Kanchan K Mukherjee, Sunil K Gupta ObjectivesOccipito-cervical(OC) fusion is often practiced for congenital atlanto-axial dislocation (CAAD) and basilar invagination (BI) with claims of good long term outcome. Little has been discussed about the delayed complications following fusing occipital […]
Does cervical disc arthroplasty have lower incidence of dysphagia than anterior cervical discectomy and fusion? A meta-analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 4 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): Zhao-Ming Zhong, Mo Li, Zhi-Min Han, Ji-Huan Zeng, Shi-Yuan Zhu, Qian Wu, Jian-Ting Chen ObjectiveDysphagia is a common occurrence after anterior cervical spine surgery. The aim of this meta-analysis was to evaluate the incidence of dysphagia after ervical disc arthroplasty (CDA) compared with […]
Motion compensated controller for a tendon-sheath-driven flexible endoscopic robot
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Background A tendon-sheath system (TSS) has the advantages of being relatively compact in size, flexible and low cost, and therefore is favoured in building flexible endoscopic robots to pass through long and tortuous human lumen. TSS, however, is prone to nonlinear behaviors such as backlash, hysteresis and direction dependent properties. A compensation technique is […]
Intradural anterior transpetrosal approach
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract The standard anterior transpetrosal approach (ATPA) for petroclival lesions is fundamentally an epidural approach and has been practiced for many decades quite successfully. However, this approach has some disadvantages, such as epidural venous bleeding around foramen ovale. We describe here our experience with a modified technique for anterior petrosectomy via an intradural approach that […]
Reconstruction of the Base of Skull Defect—Lessons Learned over 25 Combined Years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
J Neurol Surg B DOI: 10.1055/s-0036-1579779 With an increased understanding of the pathological processes involved in perinerual spread, surgery has come to play a greater role in its management. As skull base techniques have been refined, the reconstructive surgeon has been presented with increasingly complex and voluminous defects requiring repair. To enable such surgery to […]
Safety of Laparoscopic Pelvic Exenteration with Urinary Diversion for Colorectal Malignancies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1UEEzTi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TycKem via IFTTT
Frontal Sinus Malignancies
: A Population-Based Analysis of Incidence and Survival: Objective Primary neoplasms originating in the frontal sinus are rare. As such, existing literature describing frontal sinus malignancies (a subset of frontal sinus neoplasms) is limited. Prognostic implications of these malignancies are difficult to determine. This study seeks to analyze trends in epidemiology, clinicopathology, incidence, and survival for these rare malignancies. Study Design Retrospective database analysis. Methods The SEER 18 database (Surveillance, Epidemiology, and End Results; 1973-2012) was searched... περισσότερα »
Anatomic Derkay Score Is Associated with Voice Handicap in Laryngeal Papillomatosis in Adults
Anatomic Derkay Score Is Associated with Voice Handicap in Laryngeal Papillomatosis in Adults: Objective The Derkay staging system quantifies recurrent respiratory papillomatosis (RRP) severity based on involvement of laryngeal structures. Despite its broad use in the laryngology literature, the association between Derkay score and voice-related quality of life has not previously been studied. It is hypothesized that Derkay score positively correlates with the Voice Handicap Index–10 (VHI-10). Study Design Case series with chart review. Setting Tertiary medical center. Subjects ... περισσότερα »
Wire-Bristle Grill Brush Injury
Epidemiology in the United States, 2002-2014: Objectives The purpose of this study was to investigate the epidemiology of wire-bristle grill brush injury. Study Design and Setting Cross-sectional analysis of national databases; literature review. Subjects and Methods The Consumer Product Safety Commission’s National Electronic Injury Surveillance System (NEISS) was used to derive a national weighted estimate of emergency department visits for wire bristle injury from 2002 to 2014. Date, location of injury, demographics, and outcomes were analyzed. A literature search and a consume... περισσότερα »
Novel Anatomic Characteristics of the Laryngeal Framework
: A Computed Tomography Evaluation: Objective The thyroid cartilage (TC) in men has a more prominent thyroid notch and a narrower interlaminae angle (ILA) as compared with women. Anatomy textbooks classically stipulate that the ILA is 90° in men and 120° in women. Our observation, based on thyroid chondroplasty operations, of a much narrower angle led to the current investigation. Study Design Cohort imaging study. Setting Tertiary academic referral center. Subjects and Methods Computed tomography angiography neck images of adult patients were studied. The ILA was measured on 2 ...περισσότερα »
Educational Value of a Medical Student-Led Head and Neck Cancer Screening Event
Educational Value of a Medical Student-Led Head and Neck Cancer Screening Event: Objective To evaluate improvement of medical student knowledge of head and neck cancer (HNC) through participation in HNC screening fairs run by medical students. Study Design Prospective cohort study of surveys assessing medical students’ knowledge of HNC before and after volunteering at screening fairs. Setting Four screening fairs held at the University of Miami Miller School of Medicine during Oral, Head and Neck Cancer Awareness Week. Subjects Medical student screening fair volunteers. Methods...περισσότερα »
Definitive Surgical Therapy after Open Neck Biopsy for HPV-Related Oropharyngeal Cancer
Definitive Surgical Therapy after Open Neck Biopsy for HPV-Related Oropharyngeal Cancer: Objective To determine the impact of prior open neck biopsy on the prognosis of patients with human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) who are subsequently treated with a definitive surgical paradigm, including adjuvant therapy when indicated. Study Design Retrospective cohort. Setting Tertiary care university hospital. Subjects and Methods Patients with open neck biopsies who were treated with definitive surgery, with or without adjuvant therapy, for ...περισσότερα »
Novel High-Fidelity Peritonsillar Abscess Simulator
Novel High-Fidelity Peritonsillar Abscess Simulator: Objective To create and assess a novel high-fidelity peritonsillar abscess simulation task trainer with junior otolaryngology–head and neck surgery residents. Study Design Prospective cohort study. Setting Third annual Emergencies in Otolaryngology Head & Neck Surgery Bootcamp course at the Canadian Surgical Technologies & Advanced Robotics in London, Canada. Subjects and Methods Fresh cadaveric material was obtained consisting of a head and neck. Abscess pockets were simulated with a finger of a latex glove containing vanilla... περισσότερα »
Organized Hematoma
: An Analysis of 84 Cases with Emphasis on Difficult Prediction and Favorable Management: Objective To characterize features of organized hematoma (OH) that may cause considerable diagnostic difficulties. Study Design Case series with chart review. Setting Tertiary medical center. Subjects and Methods Eighty-four patients with pathologically confirmed OH over a 10-year period were retrospectively reviewed for clinical features, imaging findings, pathologic characteristics, and treatment modalities. Results This study included 39 males and 45 females who presented with frequent ... περισσότερα »
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival
: A Population-Based Analysis: Objective To describe the incidence and determinants of survival of patients with sinonasal undifferentiated carcinoma (SNUC) from 1973 to 2011 using the SEER database (Surveillance, Epidemiology, and End Results), with consideration of tumor stage based on the Kadish system. Study Design Retrospective database analysis. Setting Academic medical center. Subjects and Methods The SEER registry was utilized to calculate survival trends for 328 patients with SNUC between 1973 and 2011. Patient data were then analyzed with respect to histopathology, age...περισσότερα »
Metastasis to the Thyroid Gland: Core-Needle Biopsy and Fine-Needle Aspiration
Diagnosis of : Objectives Early detection and diagnosis of metastasis to the thyroid gland is important. This study aims to evaluate the clinical value of core-needle biopsy (CNB) by comparing the results of CNB and fine-needle aspiration (FNA) in patients with clinically suspected metastasis to the thyroid gland. Study Design Case series with chart review. Setting Tertiary referral practice. Subjects Fifty-two thyroid nodules from 52 patients with clinically suspected metastasis to the thyroid gland (mean age, 62.8 years). Methods Of these 52 patients, FNA was initially used... περισσότερα »
Tissue-Engineered Vocal Fold Mucosa Implantation
in Rabbits: Objective To assess phonatory function and wound healing of a tissue-engineered vocal fold mucosa (TE-VFM) in rabbits. An "artificial" vocal fold would be valuable for reconstructing refractory scars and resection defects, particularly one that uses readily available autologous cells and scaffold. This work implants a candidate TE-VFM after resecting native epithelium and lamina propria in rabbits. Study Design Prospective animal study. Setting Research laboratory. Subjects and Methods Rabbit adipose-derived stem cells were isolated and cultured in three-dimensiona... περισσότερα »
Neck Incision Planning for Total Laryngectomy with Pharyngectomy
Neck Incision Planning for Total Laryngectomy with Pharyngectomy: Objectives To investigate the effect of skin incision location for total laryngectomy with pharyngectomy (TLP) on postoperative outcomes including wound dehiscence and infection rate. Study Design Case series with chart review. Setting Academic tertiary care center. Methods A retrospective analysis was conducted of all patients undergoing TLP with flap closure at Johns Hopkins Medical Institutes between August 2005 and February 2013. The effects of patient characteristics and skin incision technique on postoperati...περισσότερα »
Residual Dizziness after Canalith Repositioning Procedures for Benign Paroxysmal Positional Vertigo
Features of : Objectives To assess factors related to residual dizziness (RD) in patients who underwent successful canalith repositioning procedures (CRPs) for benign paroxysmal positional vertigo (BPPV). Study Design Prospective cohort study. Setting Academic center. Subjects and Methods Ninety-seven consecutive patients with BPPV of the posterior semicircular canal were initially enrolled. Diagnosis was assessed according to clinical history and bedside evaluation. All patients were treated with CRPs until nystagmus disappeared. Three days after the successful treatment, pre... περισσότερα »
Association between Lateral Skull Base Thickness and Surgical Outcomes in Spontaneous CSF Otorrhea
Association between Lateral Skull Base Thickness and Surgical Outcomes in Spontaneous CSF Otorrhea: Objectives (1) Correlate skull base thickness with perioperative outcomes for spontaneous cerebrospinal fluid (CSF) otorrhea. (2) Augment perioperative counseling of patients with abnormally thin skull bases. Study Design Case series with chart review. Setting Tertiary center. Patients with spontaneous CSF otorrhea have thin skull bases. This is associated with obesity and/or idiopathic intracranial hypertension. The influence of skull base thinning on perioperative outcomes is unk... περισσότερα »
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique: Objective To compare the thicknesses of bone beneath the internal receiver stimulator (IRS) with the symmetric contralateral unimplanted side in postoperative temporal high-resolution computed tomography (CT) and/or cranial CT of the patients for whom cochlear implants were secured by the subperiosteal temporal pocket technique. Study Design Case series with chart review. Setting Tertiary care hospital, cochlear implant referral center. Subjects Cochlear-implanted pe... περισσότερα »
Lärmschwerhörigkeit
(BK-Nr. 2301) – Eine retrospektive Analyse von 100 konsekutiven Fällen: Laryngo-Rhino-Otol DOI: 10.1055/s-0042-102456 Einleitung: Bei der Begutachtung einer Lärmschwerhörigkeit als Berufskrankheit nach Nr. 2301 muss überprüft werden, ob die berufliche Lärmexposition die wesentliche Ursache für die Schwerhörigkeit darstellt. Mit dieser Arbeit sollte die Gruppe der zu Begutachtenden, bei der die Voraussetzungen für eine BK-Nr. 2301 vorlagen (BKE), mit denjenigen, die diese nicht erfüllten (BKNE) hinsichtlich des Vorliegens von Charakteristika einer Lärmschwerhörigkeit verglichen we... περισσότερα »
Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain
Publication date: Available online 4 April 2016 Source:Neurochemistry International Author(s): Faiz Ul Amin, Shahid Ali Shah, Myeong Ok Kim Here we investigated for the first time the inhibitory potential of Glycine (Gly) against ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in human neuroblastoma SH-SY5Y cells and in the developing rat brain. The Gly co-treatment significantly… Continue reading Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain
Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress
Publication date: Available online 4 April 2016 Source:Neurochemistry International Author(s): Changfeng Zhang, David W. Thomas In this study we sought to investigate the hypothesis that expression of the Stromal Interaction Molecule 1 (STIM1) could provide protection against cell death induced by ER and oxidative stress. STIM1 performs an essential role in regulating store operated calcium… Continue reading Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative... περισσότερα »
Focusing on the delayed complications of fusing occipital squama to cervical spine for stabilization of congenital atlantoaxial dislocation and basilar invagination
Publication date: Available online 4 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): Pravin Salunke, Sushant, Sood Sudhir, Kanchan K Mukherjee, Sunil K Gupta ObjectivesOccipito-cervical(OC) fusion is often practiced for congenital atlanto-axial dislocation (CAAD) and basilar invagination (BI) with claims of good long term outcome. Little has been discussed about the delayed complications following fusing occipital… Continue reading Focusing on the delayed complications of fusing occipital squama to cervical spine for stabilization of congenital atlantoaxial dislocati... περισσότερα »
Does cervical disc arthroplasty have lower incidence of dysphagia than anterior cervical discectomy and fusion? A meta-analysis
Publication date: Available online 4 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): Zhao-Ming Zhong, Mo Li, Zhi-Min Han, Ji-Huan Zeng, Shi-Yuan Zhu, Qian Wu, Jian-Ting Chen ObjectiveDysphagia is a common occurrence after anterior cervical spine surgery. The aim of this meta-analysis was to evaluate the incidence of dysphagia after ervical disc arthroplasty (CDA) compared with… Continue reading Does cervical disc arthroplasty have lower incidence of dysphagia than anterior cervical discectomy and fusion? A meta-analysis
Complementary and alternative medicine use by patients receiving curative-intent chemotherapy
Abstract Aim To determine which types of complementary and alternative medicine (CAM) are being used by cancer patients commencing curative-intent chemotherapy, whether the CAM taken has the potential to affect treatment efficacy, the reasons for patients’ decisions to use CAM and whether these patients would like information on CAM safety with chemotherapy. Methods Seventy-five solid… Continue reading Complementary and alternative medicine use by patients receiving curative-intent chemotherapy
Element-wise uniqueness, prior knowledge, and data-dependent resolution
Abstract Techniques for finding regularized solutions to underdetermined linear systems can be viewed as imposing prior knowledge on the unknown vector. The success of modern techniques, which can impose priors such as sparsity and non-negativity, is the result of advances in optimization algorithms to solve problems which lack closed-form solutions. Techniques for characterization and analysis of the system to determine when information is recoverable, however, still typically rely on closed-form solution techniques such as singular value decomposition or a filter cutoff estimate...περισσότερα »
Multiple access interference in MIMO-CDMA systems under Rayleigh fading: statistical characterization and applications
A major limiting factor in the performance of multiple-input-multiple-output (MIMO) code division multiple access (CDMA) systems is multiple access interference (MAI) which can reduce the system's capacity and... from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1qqJBGm via IFTTT
Ecological population genomics in the marine environment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Marine species live in a wide diversity of environments and yet, because of their pelagic life stages, are thought to be well-connected: they have high migration rates that inhibit significant population structure. Recent innovations in sequencing technologies now provide information on nucleotide polymorphisms at thousands to tens of thousands of loci based on whole genomes, […]
DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase DNA and Chromosomes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
TThe archaeal MCM helicase from Sulfolobus solfataricus (Sso) is a model for understanding structural and mechanistic aspects of DNA unwinding. Although interactions of the encircled DNA strand within the central channel provide an accepted mode for translocation, interactions with the excluded strand on the exterior surface have mostly been ignored with regard to DNA unwinding. […]
Inhibition of MMP-9-Dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4 Glycobiology and Extracellular Matrices
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Degradation and remodeling of the extracellular matrix by matrix metalloproteinases (MMPs) plays important roles in normal development, inflammation and cancer. MMP-9 efficiently degrades the extracellular matrix component gelatin and the hemopexin domain of MMP-9 (PEX9) inhibits this degradation. To study the molecular basis of this inhibition, we generated GST-fusion proteins containing PEX9 or truncated forms […]
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors Developmental Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Hematopoietic and leukemic stem cells (HSCs and LSCs) have self-renewal ability to maintain normal hematopoiesis and leukemia propagation, respectively. Tcf1 and Lef1 transcription factors are expressed in HSCs, and targeting both factors modestly expanded the size of the HSC pool due to diminished HSC quiescence. Functional defects of Tcf1/Lef1-deficient HSCs in multi-lineage blood reconstitution was […]
Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Molecular oxygen and carbon dioxide are the primary substrate and product of oxidative metabolism, respectively. Hypoxia (low oxygen) and hypercapnia (high carbon dioxide) are co-incidental features of the tissue microenvironment in a range of pathophysiologic states including acute and chronic respiratory diseases. The hypoxia inducible factor (HIF) is the master regulator of the transcriptional response […]
Ubiquitin D regulates IRE1{alpha}/JNK-dependent apoptosis in pancreatic beta cells Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes (T1D) at least in part by inducing endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). It remains to be determined what causes the transition from ″physiological″ to ″apoptotic″ UPR, but accumulating evidence indicates that signaling by the ER transmembrane protein […]
The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells including neutrophils, monocytes and endothelial cells. It has been shown to mediate anti-inflammatory and protective effects when administered in disease models, in part, by reducing neutrophil infiltration. Human TSG-6 inhibits neutrophil migration by binding CXCL8 through […]
Inorganic phosphate limitation modulates capsular polysaccharide composition in mycobacteria Microbiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Mycobacterium tuberculosis is protected by an unusual and highly impermeable cell-envelope that is critically important for the successful colonisation of the host. The outermost surface of this cell envelope is formed by capsular polysaccharides that play an important role in modulating the initial interactions once the bacillus enters the body. Although the bio-enzymatic steps involved […]
Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR {alpha}2 subunit knock-in mouse Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
The accumulation of γ-aminobutyric acid receptors (GABAARs) at the appropriate postsynaptic sites is critical in determining the efficacy of fast inhibitory neurotransmission. While we know that the majority of synaptic GABAAR subtypes are assembled from α1-3, β and γ2 subunits, our understanding of how neurons facilitate their targeting to, and stabilization at inhibitory synapses is […]
Molecular mechanism of regulation of MTA1 by Granulocyte Colony Stimulating Factor Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Parkinson’s disease (PD) is a neurodegenerative disorder with loss of dopaminergic neurons of the brain, which results in insufficient synthesis and action of dopamine. Metastasis associated protein 1 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), rate limiting enzyme in dopamine (DA) synthesis and hence MTA1 plays a significant role in PD pathogenesis. To […]
Significance of R1 Resection for Advanced Colorectal Liver Metastases in the Era of Modern Effective Chemotherapy
Abstract Background The prognosis impact of positive margins after resection of colorectal liver metastases (CLM) in patients treated with modern effective chemotherapy has not been elucidated. The objective was to compare oncologic outcomes after R0 and R1 resections in the era of modern effective chemotherapy. Methods Between 1999 and 2010, all consecutive patients undergoing liver resection for CLM were analyzed retrospectively. Patients with extrahepatic metastases, macroscopic residual tumor, treated with combined radiofrequency, or not treated with chemotherapy were exclude... περισσότερα »
Surgical Apgar Score Predicted Postoperative Morbidity After Esophagectomy for Esophageal Cancer
Abstract Background Recently, a simple and easy complication prediction system, the Surgical Apgar Sore (SAS) calculated by three intraoperative parameters (estimated blood loss, lowest mean arterial pressure, and lowest heart rate), has been proposed for general surgery. This study aimed to determine if the SAS could accurately predict perioperative morbidity in patients undergoing esophagectomy for esophageal cancer. Methods We investigated 399 patients who underwent esophagectomy at the Kumamoto University Hospital between April 2007 and March 2015. Clinical data, including in... περισσότερα »
Post-Hospital Discharge Venous Thromboembolism in Colorectal Surgery
Abstract Background There are limited data regarding the criteria for prophylactic treatment of venous thromboembolism (VTE) after hospital discharge. We sought to identify risk factors of post-hospital discharge VTE events following colorectal surgery. Methods The NSQIP database was utilized to examine patients developed VTE after hospital discharge following colorectal surgery during 2005–2013. Multivariate analysis using logistic regression was performed to quantify risk factors of VTE after discharge. Results We evaluated a total of 219,477 patients underwent colorectal rese... περισσότερα »
Observation Versus Embolization in Patients with Blunt Splenic Injury After Trauma: A Propensity Score Analysis
Abstract Background Non-operative management (NOM) is the standard of care in hemodynamically stable patients with blunt splenic injury after trauma. Splenic artery embolization (SAE) is reported to increase observation success rate. Studies demonstrating improved splenic salvage rates with SAE primarily compared SAE with historical controls. The aim of this study was to investigate whether SAE improves success rate compared to observation alone in contemporaneous patients with blunt splenic injury. Methods We included adult patients with blunt splenic injury admitted to five Leve...περισσότερα »
Important Mutations Contributing to High-Level Penicillin Resistance in Taiwan19F-14, Taiwan23F-15, and Spain23F-1 of Streptococcus pneumoniae Isolated from Taiwan
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/1N5IXTo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RKyuio via IFTTT
Dynamic RSA: Examining parasympathetic regulatory dynamics via vector-autoregressive modeling of time-varying RSA and heart period
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration […]
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
from #Dental via xlomafota13 on Inoreader http://ift.tt/1TxZPsM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RYQj2J via IFTTT
Dynamic RSA: Examining parasympathetic regulatory dynamics via vector-autoregressive modeling of time-varying RSA and heart period
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Expanding on recently published methods, the current study presents an approach to estimating the dynamic, regulatory effect of the parasympathetic nervous system on heart period on a moment-to-moment basis. We estimated second-to-second variation in respiratory sinus arrhythmia (RSA) in order to estimate the contemporaneous and time-lagged relationships among RSA, interbeat interval (IBI), and respiration […]
Effects of body mass index, tobacco smoking, alcohol drinking and solid fuel use on the risk of asthma: Individual Participant Data (IPD) meta-analysis of 175 000 individuals from 51 nationally representative surveys
Background We assessed the relationship of body mass index (BMI), smoking, drinking and solid fuel use (r; SFU), and the individual and combined effects of these factors on wheezing symptoms (WS) and on diagnosed asthma (DA). Methods We analysed 175 000 individuals from 51 nationally representative surveys, using self-reports of WS and DA as the… Continue reading Effects of body mass index, tobacco smoking, alcohol drinking and solid fuel use on the risk of asthma: Individual Participant Data (IPD) meta-analysis of 175 000 individuals from 51 nationally representative surveys
DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase DNA and Chromosomes
TThe archaeal MCM helicase from Sulfolobus solfataricus (Sso) is a model for understanding structural and mechanistic aspects of DNA unwinding. Although interactions of the encircled DNA strand within the central channel provide an accepted mode for translocation, interactions with the excluded strand on the exterior surface have mostly been ignored with regard to DNA unwinding.… Continue reading DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase DNA and Chromosomes
Inhibition of MMP-9-Dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4 Glycobiology and Extracellular Matrices
Degradation and remodeling of the extracellular matrix by matrix metalloproteinases (MMPs) plays important roles in normal development, inflammation and cancer. MMP-9 efficiently degrades the extracellular matrix component gelatin and the hemopexin domain of MMP-9 (PEX9) inhibits this degradation. To study the molecular basis of this inhibition, we generated GST-fusion proteins containing PEX9 or truncated forms… Continue reading Inhibition of MMP-9-Dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4 Glycobiology and Extrace... περισσότερα »
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors Developmental Biology
Hematopoietic and leukemic stem cells (HSCs and LSCs) have self-renewal ability to maintain normal hematopoiesis and leukemia propagation, respectively. Tcf1 and Lef1 transcription factors are expressed in HSCs, and targeting both factors modestly expanded the size of the HSC pool due to diminished HSC quiescence. Functional defects of Tcf1/Lef1-deficient HSCs in multi-lineage blood reconstitution was… Continue reading Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors Developmental Biology
Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia Molecular Bases of Disease
Molecular oxygen and carbon dioxide are the primary substrate and product of oxidative metabolism, respectively. Hypoxia (low oxygen) and hypercapnia (high carbon dioxide) are co-incidental features of the tissue microenvironment in a range of pathophysiologic states including acute and chronic respiratory diseases. The hypoxia inducible factor (HIF) is the master regulator of the transcriptional response… Continue reading Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia Molecular Bases of Disease
Ubiquitin D regulates IRE1{alpha}/JNK-dependent apoptosis in pancreatic beta cells Cell Biology
Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes (T1D) at least in part by inducing endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). It remains to be determined what causes the transition from ″physiological″ to ″apoptotic″ UPR, but accumulating evidence indicates that signaling by the ER transmembrane protein… Continue reading Ubiquitin D regulates IRE1{alpha}/JNK-dependent apoptosis in pancreatic beta cells Cell Biology
The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions Protein Structure and Folding
TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells including neutrophils, monocytes and endothelial cells. It has been shown to mediate anti-inflammatory and protective effects when administered in disease models, in part, by reducing neutrophil infiltration. Human TSG-6 inhibits neutrophil migration by binding CXCL8 through… Continue reading The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions Protein Structure and Folding
Inorganic phosphate limitation modulates capsular polysaccharide composition in mycobacteria Microbiology
Mycobacterium tuberculosis is protected by an unusual and highly impermeable cell-envelope that is critically important for the successful colonisation of the host. The outermost surface of this cell envelope is formed by capsular polysaccharides that play an important role in modulating the initial interactions once the bacillus enters the body. Although the bio-enzymatic steps involved… Continue reading Inorganic phosphate limitation modulates capsular polysaccharide composition in mycobacteria Microbiology
Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR {alpha}2 subunit knock-in mouse Cell Biology
The accumulation of γ-aminobutyric acid receptors (GABAARs) at the appropriate postsynaptic sites is critical in determining the efficacy of fast inhibitory neurotransmission. While we know that the majority of synaptic GABAAR subtypes are assembled from α1-3, β and γ2 subunits, our understanding of how neurons facilitate their targeting to, and stabilization at inhibitory synapses is… Continue reading Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR {alpha}2 subunit knock-in mouse Cell Biology
Molecular mechanism of regulation of MTA1 by Granulocyte Colony Stimulating Factor Cell Biology
Parkinson’s disease (PD) is a neurodegenerative disorder with loss of dopaminergic neurons of the brain, which results in insufficient synthesis and action of dopamine. Metastasis associated protein 1 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), rate limiting enzyme in dopamine (DA) synthesis and hence MTA1 plays a significant role in PD pathogenesis. To… Continue reading Molecular mechanism of regulation of MTA1 by Granulocyte Colony Stimulating Factor Cell Biology
Coping Strategies and Posttraumatic Stress Symptoms in Post-ICU Family Decision Makers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Critical care medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1URTQRh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Methods in molecular biology (Clifton, N.J.) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1N5Gh8t via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Masthead
from #Dental via xlomafota13 on Inoreader http://ift.tt/1YcwSSt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Issue Information
from #Dental via xlomafota13 on Inoreader http://ift.tt/1TxZPsM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Congenital Epulis
What do we currently know about congenital epulis? What are the management options for this condition? *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1RYNU82 via IFTTT
Congenital Epulis
What do we currently know about congenital epulis? What are the management options for this condition? *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1RYNU82 via IFTTT
How do women with chronic fatigue syndrome/myalgic encephalomyelitis rate quality and coordination of healthcare services? A cross-sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To test the association between self-rated health and self-rated degree of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), and CFS/ME patients’ assessment of quality of primary care, specialist care and coordination of care. Design Cross-sectional study. Setting Self-reported questionnaire data from women members of The Norwegian ME Association obtained in 2013. Participants 431 women with CFS/ME […]
Dead space closure with quilting suture versus conventional closure with drainage for the prevention of seroma after mastectomy for breast cancer (QUISERMAS): protocol for a multicentre randomised controlled trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction Postoperative wound seroma is common after mastectomy. This complication is associated with significant impact on patient outcomes and healthcare costs. The optimal closure approach for seroma prevention remains unknown but some evidence suggests that quilting suture of the dead space could lower the incidence of seroma. The aim of this trial is to compare […]
Counterfeit medicines in Peru: a retrospective review (1997-2014)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To consolidate and assess information on counterfeit medicines subject to pharmaceutical alerts issued by the Peruvian Medicines Regulatory Authority over 18 years (1997–2014) of health monitoring and enforcement. Design A retrospective review of drug alerts. Setting A search of the website of the General Directorate of Medicines, Supplies and Drugs (DIGEMID) of the Ministry […]
Disability pension due to common mental disorders and subsequent suicidal behaviour: a population-based prospective cohort study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Adverse health outcomes, including suicide, in individuals on disability pension (DP) due to mental diagnoses have been reported. However, scientific knowledge on possible risk factors for suicidal behaviour (suicide attempt and suicide) in this group, such as age, gender, underlying DP diagnoses, comorbidity and DP duration and grade, is surprisingly sparse. This study aimed […]
Factors associated with polypharmacy and excessive polypharmacy in older people with intellectual disability differ from the general population: a cross-sectional observational nationwide study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives (1) To evaluate the prevalence of polypharmacy (5–9 medicines) and excessive polypharmacy (10+ medicines) and (2) to determine associated demographic and clinical characteristics in an ageing population with intellectual disabilities (IDs). Design Observational cross-sectional study. Setting Wave One (2009/2010) of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). Participants A […]
Age at Primary Malignancy Determines Survival in Adolescent and Young Adults That Develop a Secondary Thyroid Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Journal of Adolescent and Young Adult Oncology , Vol. 0, No. 0. from Cancer via ola Kala on Inoreader http://ift.tt/202ir4U via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PR0nmA via IFTTT
Psychometric Analysis of the Three-Factor Eating Questionnaire-R18V2 in Adolescent and Young Adult-Aged Central Nervous System Tumor Survivors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Journal of Adolescent and Young Adult Oncology , Vol. 0, No. 0. from Cancer via ola Kala on Inoreader http://ift.tt/1V5R5LA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1V5R3TK via IFTTT
Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis – a short report
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose CYLD is a tumor suppressor that has been linked to the development of various human malignancies, including colon cancer. The tumor-suppressing function of CYLD is associated with its deubiquitinating activity, which maps to the carboxyl-terminal region of the protein. In the present study we evaluated the role of intestinal epithelial CYLD in colitis-associated […]
TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose Tumor progression is associated with cell migration, invasion and metastasis. These processes are accompanied by the activation of specific proteases that are either linked to cellular membranes or are secreted into extracellular spaces. TNF-α is known to play an important role in various aspects of tumor progression. The aim of this work was […]
