Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions
Abstract Hereditary lactate dehydrogenase (LDH) M-subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis-like lesions. We report a third case of pustular psoriasis-like eruptions associated with LDH M-subunit deficiency, which occurred 24 years after the diagnosis of LDH M-subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M-subunit deficiency have antecedent... περισσότερα »
Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] Abstract Adalimumab is a biologic that is very effective for treatment of psoriasis. However, recalcitrant or recurrent lesions sometimes occur during treatment. Maxacalcitol is an active vitamin D3 ointment that is effective in treatment of psoriasis. Topical therapy may be beneficial in treatment of recalcitrant or recurrent lesions during treatment with systemic therapy, but there is little evidence on this topic. We investigated the effect of maxacalcitol on skin lesions during treatment with adalimumab in patients with psoria... περισσότερα »
Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata
Abstract Severe alopecia areata (AA) can have an unpredictable clinical course and become refractory to contact immunotherapy. Novel treatment options include low-dose interleukin-2 and Janus kinase inhibitors; however, these treatments are still under investigation. Therefore, we evaluated the efficacy and safety of intramuscular (i.m.) triamcinolone acetonide (TAC) as a rescue therapy for refractory AA. We retrospectively analysed efficacy, adverse effects and relapse rate of i.m. TAC monthly in 27 patients with refractory AA. We defined AA as refractory if the patient showed an... περισσότερα »
Topical 5% imiquimod eliminated human papillomavirus 16-associated Bowen's disease
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Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata
Abstract Severe alopecia areata (AA) can have an unpredictable clinical course and become refractory to contact immunotherapy. Novel treatment options include low-dose interleukin-2 and Janus kinase inhibitors; however, these treatments are still under investigation. Therefore, we evaluated the efficacy and safety of intramuscular (i.m.) triamcinolone acetonide (TAC) as a rescue therapy for refractory AA. We… Continue reading Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata
New Directions in Gaucher Disease
ABSTRACT In Gaucher disease (GD) mutant lysosomal acid β-glucocerebrosidase fails to properly hydrolyze its substrate, glucosylceramide, which accumulates in the lysosomes. Due to its phenotypic heterogeneity, GD has been classified into type 1, non-neuronopathic, and types 2 and 3, the neuronopathic forms, based on the primary involvement of the central nervous system. Neuroinflammation and necroptotic… Continue reading New Directions in Gaucher Disease
Topical 5% imiquimod eliminated human papillomavirus 16-associated Bowen’s disease
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Decomposing mechanisms of abnormal saccade generation in schizophrenia patients: Contributions of volitional initiation, motor preparation, and fixation release
Abstract Clinical and theoretical models suggest deficient volitional initiation of action in schizophrenia patients. Recent research provided an experimental model of testing this assumption using saccade tasks. However, inconsistent findings necessitate a specification of conditions on which the deficit may occur. The present study sought to detect mechanisms that may contribute to poor performance. Sixteen… Continue reading Decomposing mechanisms of abnormal saccade generation in schizophrenia patients: Contributions of volitional initiation, motor preparation, and fixation release
Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions
Abstract Cutaneous mucinoses encompass a variety of cutaneous disorders. Cutaneous focal mucinosis (CFM) was originally described as an asymptomatic solitary lesion characterized by abundant focal cutaneous mucin deposits. However, multiple focal mucinous lesions associated with systemic diseases have also been designated as CFM. Our clinicopathological study of 11 cases of solitary lesions confirmed that CFM… Continue reading Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions
Successful treatment of Kyrle disease with narrowband ultraviolet B
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Cardiac cycle time effects on selection efficiency in vision
Abstract The effect of cardiac cycle time on attentional selection was investigated in an experiment in which participants classified target letters in a visual selection task. Stimulus onsets were aligned to the R wave of the electrocardiogram and stimuli presented either during the ventricular systole or diastole. Selection efficiency was operationalized as difference in target… Continue reading Cardiac cycle time effects on selection efficiency in vision
Symptom prevalence in patients with advanced skin cancer
Abstract Knowledge of the prevalence of symptoms in patients with incurable cancer in the terminal stage is important for clinicians. However, there has been no report on the prevalence of symptoms in patients with incurable skin cancer. We analyzed the prevalence of symptoms in 224 patients who died due to skin cancer in our center.… Continue reading Symptom prevalence in patients with advanced skin cancer
Impact of ENSO on variability of AIRS retrieved CO2 over India
Publication date: October 2016 Source:Atmospheric Environment, Volume 142 Author(s): K. Ravi Kumar, Yogesh K. Tiwari, J.V. Revadekar, Ramesh Vellore, Tania Guha This study investigates the impact of ENSO on the CO2 variability over the Indian subcontinent for the period 2003–2011 based on the relationships between NINO indices derived from the sea surface temperature (SST) and… Continue reading Impact of ENSO on variability of AIRS retrieved CO2 over India
Deriving aerosol hygroscopic mixing state from size-resolved CCN activity and HR-ToF-AMS measurements
Publication date: October 2016 Source:Atmospheric Environment, Volume 142 Author(s): Deepika Bhattu, S.N. Tripathi, Abhishek Chakraborty The ability of a particle to uptake water and form a cloud droplet depends on its hygroscopicity. To understand its impact on cloud properties and ultimately radiative forcing, knowledge of chemically-resolved mixing state information or the one based on hygroscopic… Continue reading Deriving aerosol hygroscopic mixing state from size-resolved CCN activity and HR-ToF-AMS measurements
Risk assessment in poisoning with special reference to odollam and organophosphorous compounds
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 19 δευτερόλεπτα
2016-07-23T02-33-29Z *Source:* International Journal of Research in Medical Sciences Meenu M. Tergestina, Sunitha Simon. Background: Poisoning with organophosphorous compounds, odollam and other substances are common. Affected persons present with a wide variety of clinical features. Prognostic indicators of high mortality are important for management and to decide on intensive care unit admission. Methods: Admissions due to poisonings from April 2015 to March 2016 were assessed. The clinical features, electrocardiographic changes and laboratory investigations of 915 patients were o... περισσότερα »
Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness
[image: S03785955.gif] Publication date: Available online 22 July 2016 *Source:*Hearing Research Author(s): Min-Hyun Park, Jeong Hun Jang, Jae-Jin Song, Ho Sun Lee, Seung Ha Oh Deafness induces many plastic changes in the auditory neural system. For instance, dendritic changes cause synaptic changes in neural cells. SMI-32, a monoclonal antibody reveals auditory areas and recognizes non-phosphorylated epitopes on medium- and high-molecular-weight subunits of neurofilament proteins in cortical pyramidal neuron dendrites. We investigated SMI-32-immunoreactive (-ir) protein levels in t... περισσότερα »
Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness
[image: S03785955.gif] Publication date: Available online 22 July 2016 *Source:*Hearing Research Author(s): Min-Hyun Park, Jeong Hun Jang, Jae-Jin Song, Ho Sun Lee, Seung Ha Oh Deafness induces many plastic changes in the auditory neural system. For instance, dendritic changes cause synaptic changes in neural cells. SMI-32, a monoclonal antibody reveals auditory areas and recognizes non-phosphorylated epitopes on medium- and high-molecular-weight subunits of neurofilament proteins in cortical pyramidal neuron dendrites. We investigated SMI-32-immunoreactive (-ir) protein levels in t... περισσότερα »
Ειδοποίηση Μελετητή - [ Nose's Diseases ]
*Ειδοποίηση Μελετητή:[ Nose's Diseases ]* [PDF] Nausea and vomiting masquerading heart cancer JS Shapiro, VC Vasile, KW Klarich, HV Schaff - Journal of Solid Tumors, 2016 *...* 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States 2Division of Cardiovascular *Diseases*, Mayo Clinic, Rochester, Minnesota, United States *...* 3:1 – and the right atrium (RA) is the most frequent location.[4] The differential diag- *noses* for a cardiac *...* Leech therapy in flap salvage: Systematic review and practical recommendations C Herlin, N Bertheuil, F Bekara, F Boi... περισσότερα »
Ειδοποίηση Μελετητή - [ Head and Neck's Diseases ]
*Ειδοποίηση Μελετητή:[ Head and Neck's Diseases ]* Oral Health Status of Patients Undergoing Treatment for *Head *and *Neck *Oncology in Northern Ireland. C Moore, S Killough, N Markey, L Winning, G McKenna - The European journal of …, 2016 *...* Data were collected on all patients referred to the Northern Ireland Multidisciplinary *Head* and *Neck* Oncology Team for discussion and treatment *...* During the course of the study 96 patients were assessed and the levels of dental *disease* observed in this cohort were high. *...* Stroke after Radiotherapy for *Head *and *Neck *Cancer... περισσότερα »
Ειδοποίηση Μελετητή - [ Cochlea's Diseases ]
*Ειδοποίηση Μελετητή:[ Cochlea's Diseases ]* Apical hair cell degeneration causes the increase in the amplitude of summating potential D Wang, B Xiong, F Xiong, GD Chen, BH Hu, W Sun - Acta Oto-Laryngologica, 2016 *...* F-actin cleavage in apoptotic outer hair cells in chinchilla *cochleas* exposed to intense noise. *...* change of SP may be affected by the hair cell loss at different regions of the *cochlea*. *...* Lack of vestibular symptoms is not consistent with the clinical spectrum of Meniere's *diseases*. *...* [PDF] The prevalence of sensorineural hearing loss in patients w... περισσότερα »
Ειδοποίηση Μελετητή - [ Pharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ Pharynx's Diseases ]* [PDF] A Case Report of Multiple Aseptic Facial and Spinal Abscesses in a 45-Year-Old with Inflammatory Bowel *Disease* MD Zheng, MD Jackson, MD Francis, MD Niu - The Medicine Forum, 2016 *...* Cases involving the lung, brain, muscle, and *pharynx* have also been described in the *...* abscess syndrome is an under-recognized entity in auto-inflammatory *diseases*, as evidenced *...* Aseptic abscesses present a major, complication of inflammatory bowel *disease* that mimic the *...* [HTML] VIDEOFLUOROSCOPIC EVALUATION OF SWALLOWS IN ANOREXI... περισσότερα »
Ειδοποίηση Μελετητή - [ Melanoma ]
*Ειδοποίηση Μελετητή:[ Melanoma ]* *Melanoma *Exosome Induction of Endothelial Cell GM-CSF in Pre-metastatic Lymph Nodes may Result in Different M1 and M2 Macrophage Mediated Angiogenic … JL Hood - Medical Hypotheses, 2016 Summary Angiogenesis is a key process in the preparation of lymph nodes for *melanoma * metastasis. Granulocyte macrophage colony stimulating factor (GM-CSF) induces hypoxia inducible factor 1 alpha (HIF-1α) in M1 or HIF-2α in M2 polarized macrophages. HIF-1α * ...* *Melanoma *affects the composition of blood cell-derived extracellular vesicles N Koliha, U Heide... περισσότερα »
Ειδοποίηση Μελετητή - [ Thyroid ]
*Ειδοποίηση Μελετητή:[ Thyroid ]* Adeno associated virus 9-based gene therapy delivers a functional monocarboxylate transporter 8 (MCT8) which improves *thyroid *hormone availability to brain of … H Iwayama, XH Liao, L Braun, S Bárez-López… - *Thyroid*, 2016 Background: MCT8 gene mutations produce *thyroid *hormone (TH) deficiency in the brain, causing severe neuropsychomotor abnormalities not correctable by treatment with TH. In this proof of concept study, we examined whether transfer of human MCT8 (hMCT8) cDNA * ...* ß-catenin signaling is required for RAS-driven *thyroid *canc... περισσότερα »
Ειδοποίηση Μελετητή - [ HypoPharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ HypoPharynx's Diseases ]* Stroke after Radiotherapy for Head and Neck Cancer–What is the Risk? E Arthurs, TP Hanna, K Zaza, Y Peng, SF Hall - International Journal of Radiation …, 2016 *...* *hypopharynx* and nasopharynx between January 1st, 1990 and January 31st, 2010. *...* Chronic obstructive pulmonary *disease* and asthma were, however, used as proxies *...* accuracy of these *diseases* in predicting smoking behavior within our data sources is not known. *...* Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcino... περισσότερα »
Ειδοποίηση Μελετητή - [ Larynx's Diseases ]
*Ειδοποίηση Μελετητή:[ Larynx's Diseases ]* Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study Y Nakata, K Ijichi, N Hanai, D Nishikawa, H Suzuki… - Auris Nasus *Larynx*, 2016 *...* of *disease* and three died of primary *disease*. Three patients died of other *diseases*; one committed suicide, one developed pneumonia and one had stomach cancer. The estimated 5-year survival rate was 77.4% (95%CI, 56.3–89.2%) (Fig. 3b). *Larynx* preservation was *...* [PDF] Indoor Biomass Fuel Smoke Exposure a... περισσότερα »
Ειδοποίηση Μελετητή - [ Throat's Diseases ]
*Ειδοποίηση Μελετητή:[ Throat's Diseases ]* Letter to the Editor Recurrent Kawasaki *Disease* M Helmi, M Saleh, B Yacop, E Malik - HK J Paediatr (New Series), 2016 *...* Kawasaki *disease* (KD) is a *disease* of unknown etiology. It is a vasculitic *disease*, which affects coronary arteries especially small, and medium size ones. *...* ASO titer: 800 IU/ML. Blood culture, *Throat* Culture and virology study were negative. *...* Распространенность болезней уха, горла и носа у городского населения НЮ Сказатова, ГЗ Пискунов - Кремлевская медицина. Клинический вестник, 2016 *...* To prope... περισσότερα »
Ειδοποίηση Μελετητή - [ Hearing ]
*Ειδοποίηση Μελετητή:[ Hearing ]* A Case of *Hearing *Loss after Bilateral Putaminal Hemorrhage: A Diffusion-tensor Imaging Study T Koyama, K Domen - Progress in Rehabilitation Medicine, 2016 ABSTRACT Background: Magnetic resonance diffusion-tensor imaging (DTI) is a tool forthe assessment of neural fiber integrity. We applied DTI in a patient with *hearing *lossthat developed after bilateral putaminal hemorrhage. Case: A 59-year-oldwoman was referred * ...* Pedestrian evacuation in view and *hearing *limited condition: The impact of communication and memory S Xue, B Jia, R Jiang,... περισσότερα »
Ειδοποίηση Μελετητή - [ Ear's Diseases ]
*Ειδοποίηση Μελετητή:[ Ear's Diseases ]* Gustatory function in chronic otitis media (mucosal type) before and after tympanoplasty A Krishna, SV Babu, SMA Mohiyuddin, K Naseeruddin - European Archives of Oto- …, 2016 *...* 1. Landis BN, Beutner D, Frasnelli J, Huttenbrink KB, Hummel T (2005) Gustatory function in chronic inflammatory middle *ear* *diseases*. *...* Arnold publishers, Great Britain, pp 3105–3125 3. Arnold SM (1974) The vulnerability of the chorda tympani nerve to middle *ear* *disease*. *...* Triple semicircular canal plugging: a novel modality for the treatment of i... περισσότερα »
Ειδοποίηση Μελετητή - [ Salivary Glands ]
*Ειδοποίηση Μελετητή:[ Salivary Glands ]* [PDF] *Salivary *flow rate in adult Kenyans and its relationship with chronic periodontitis M Mbabali, TK Mulli, E Wagaiyu - Journal of Dentistry and Oral Hygiene, 2016 *...* Percival RS, Challacombe SJ, Marsh PD (1994). Flow rates of resting whole and stimulated *parotid* saliva in relation to age and gender. J. Dent Res. *...* Shern RJ, Fox PC, Li SH (1993). Influence of age on the secretory rates of the human minor *salivary* *glands* and whole saliva. *...* Intravoxel incoherent motion imaging measurement of perfusion changes in the *pa... περισσότερα »
Ειδοποίηση Μελετητή - [ Foreign Body Aspiration ]
*Ειδοποίηση Μελετητή:[ Foreign Body Aspiration ]* Development and characterization of a technique for percutaneous radiologic gastrojejunostomy tube placement in the dog RM Mack, B Staiger, DK Langlois, SJ Mehler, N Lam… - Journal of Veterinary …, 2016 *...* tract and uses a distal postpyloric feeding technique, which has been shown to reduce gastric volumes and minimize *aspiration*.[16]. *...* 1 dog did develop an obstruction on day 5. Radiographically and ultrasonographically, the obstruction was consistent with a linear *foreign* *body*. *...* [HTML] Practice Recommendation Pra... περισσότερα »
Ειδοποίηση Μελετητή - [ Vertigo ]
*Ειδοποίηση Μελετητή:[ Vertigo ]* Incidence and Localizing Value of *Vertigo *and Dizziness in Patients with Epilepsy: Video-EEG monitoring study DW Kim, JS Sunwoo, SK Lee - Epilepsy Research, 2016 Abstract *Vertigo *and dizziness are common neurological complaints that have long been associated with epilepsy. However, studies of patients with epileptic *vertigo *or dizziness with concurrent EEG monitoring are scarce. We performed the present study to investigate the * ...* Triple semicircular canal plugging: a novel modality for the treatment of intractable Meniere's disease D Zh... περισσότερα »
Ειδοποίηση Μελετητή - [ NasoPharynx's Diseases ]
*Ειδοποίηση Μελετητή:[ NasoPharynx's Diseases ]* [PDF] Indoor Biomass Fuel Smoke Exposure as a Risk Factor for Chronic Obstructive Pulmonary *Disease *(COPD) for Women of Rural Bangladesh RSR Biswas, S Paul, MR Rahaman, MA Sayeed… - Chattagram Maa-O-Shishu …, 2016 *...* including Acute Respiratory Infections (ARI) and Otitis media (Middle Ear Infection) Chronic Obstructive Pulmonary *Disease* (COPD) Lung cancer, Asthma, Cancer of the *nasopharynx* and larynx, Tuberculosis, Perinatal conditions and Low birth weight, and *diseases* of the eye *...* Stroke after Radiotherapy for Head a... περισσότερα »
Venous air embolus during prone cervical spine fusion: case report
Journal of Neurosurgery: Spine, Ahead of Print. Venous air embolism (VAE) is a known neurosurgical complication classically and most frequently occurring in patients undergoing posterior cranial fossa or cervical spine surgery in a sitting or semi-sitting position. The authors present a case of VAE that occurred during posterior cervical spine surgery in a patient in the prone position, a rare intraoperative complication. The patient was a 65-year-old man who was undergoing a C1–2 fusion for a nonunion of a Type II dens fracture and developed a VAE. While VAE in the prone position ... περισσότερα »
Spinal cord anomalies in patients with anorectal malformations without severe sacral abnormalities or meningomyelocele: outcomes after expectant, conservative management
Journal of Neurosurgery: Spine, Ahead of Print. OBJECTIVE The goal of this study was to determine the significance of spinal cord anomalies (SCAs) in patients with anorectal malformations (ARMs) by comparing the outcomes for bowel function, lower urinary tract symptoms (LUTS), and lower-limb neurological abnormalities to these outcomes in patients with similar ARMs and a normal spinal cord. METHODS The spinal cord MRI records of female patients treated for vestibular and perineal fistula (VF/PF) and male patients with rectourethral fistula (RUF) at a single center between 1983 and ... περισσότερα »
Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis
Journal of Neurosurgery, Ahead of Print. The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergo... περισσότερα »
Influenza A (H10N7) Virus Causes Respiratory Tract Disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
in Harbor Seals and Ferrets: by Judith M. A. van den Brand, Peter Wohlsein, Sander Herfst, Rogier Bodewes, Vanessa M. Pfankuche, Marco W. G. van de Bildt, Frauke Seehusen, Christina Puff, Mathilde Richard, Ursula Siebert, Kristina Lehnert, Theo Bestebroer, Pascal Lexmond, Ron A. M. Fouchier, Ellen Prenger-Berninghoff, Werner Herbst, Marion Koopmans, Albert D. M. E. […]
Hydrocephalus and Chiari I malformation in sagittal craniosynostosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Contemporary occurrence of hydrocephalus and Chiari I malformation in sagittal craniosynostosis. Case report and review of the literature: Abstract Chiari malformation type I (CM-I) and hydrocephalus are often associated with complex craniosynostosis. On the contrary, their simultaneous occurrence in monosutural synostosis is extremely rare. The pathophysiological hypothesis is that they may alter posterior fossa growth […]
Leveraging Epstein–Barr virus in research and therapy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
The other side of the coin: via Salivary Glands Publication date: September 2016Source:Oral Oncology, Volume 60Author(s): Fenggang Yu, Wei Jian Tan, Yanan Lu, Paul A. MacAry, Kwok Seng LohEpstein-Barr virus is (EBV) a ubiquitous virus prevalent in 90% of the human population. Transmitted through infected saliva, EBV is the causative agent of infectious mononucleosis (IM) and […]
Recurrent High-Grade Invasive Mucoepidermoid Carcinoma of Larynx
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
: A Case Report and Review of the Literature.: Rare Tumors. 2016;8(2):6204 Authors: King W, Ko S, Miller D Abstract Recurrent invasive high-grade mucoepidermoid carcinoma of the larynx and hypopharynx is a rare occurrence. These tumors have been commonly associated with salivary gland tumors, most commonly the parotid gland. The patient usually presents with the […]
Clinicopathological characteristics of head and neck Merkel cell carcinomas
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Clinicopathological characteristics of head and neck Merkel cell carcinomas: Abstract Background There are still controversies about the therapeutic strategies and subsequent outcome in head and neck Merkel cell carcinoma. Methods Clinicopathological data of 23 Merkel cell carcinomas, 93 cutaneous head and neck squamous cell carcinomas (HNSCCs), 126 malignant melanomas, and 91 primary parotid gland carcinomas […]
Tonal noise of a controlled-diffusion airfoil at low angle of attack and Reynolds number
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Tonal noise of a controlled-diffusion airfoil at low angle of attack and Reynolds number: The acoustic signature of a controlled-diffusion airfoil immersed in a flow is experimentally characterized. Acoustic measurements have been carried out in an anechoic open-jet-wind-tunnel for low Reynolds numbers (from 5 × 104 to 4.3 × 105) and several angles of attack. As with the NACA0012, […]
Treatment of large persistent tracheoesophageal peristomal fistulas
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
using silicon rings via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Author(s): Ibrahim Erdim, Ali Ahmet Sirin, Bahadir Baykal, Fatih Oghan, Ali Guvey, Fatma Tulin KayhanIntroductionTracheoesophageal peristomal fistulae can often be solved by reducing the size of the fistula or replacing the prosthesis; however, even with conservative techniques, leakage around the fistula may continue in total laryngectomy […]
Recognition and importance in patient safety
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Situational awareness – what it means for clinicians, its recognition and importance in patient safety: Abstract A thorough understanding of the role of human factors in error in health care for improving patient safely is paramount. One area particularly crucial for optimising clinical performance is the recognising the importance of situational awareness. Loss of situation […]
Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
[image: S03785955.gif] Publication date: Available online 22 July 2016 *Source:*Hearing Research Author(s): Min-Hyun Park, Jeong Hun Jang, Jae-Jin Song, Ho Sun Lee, Seung Ha Oh Deafness induces many plastic changes in the auditory neural system. For instance, dendritic changes cause synaptic changes in neural cells. SMI-32, a monoclonal antibody reveals auditory areas and recognizes non-phosphorylated epitopes on medium- and high-molecular-weight subunits of neurofilament proteins in cortical pyramidal neuron dendrites. We investigated SMI-32-immunoreactive (-ir) protein levels in t... περισσότερα »
Clinical Pathway Implementation Improves Efficiency of Care in a Maxillofacial Head and Neck Surgery Unit
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Jacob G. Yetzer, Phillip Pirgousis, Zhuo Li, Rui Fernandes PurposeClinical pathways have become an important and simple method of improving patient outcomes while reducing healthcare resource utilization. The purpose of this study was to evaluate the early outcomes associated with the implementation of a clinical pathway within a Maxillofacial Head and Neck Surgery unit.Materials and MethodsThis investigation is a retrospective cohort study of patients who underwent microvasc... περισσότερα »
Simultaneous Bilateral Hypertrophies of The Parotid Gland and Masseter Muscle: Case Report
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Rohan Prabhu, Louis Mandel Increased salivary demand can lead to enlarged parotid salivary glands, while increased activity of the masseter muscles will cause masseter hypertrophy. The authors report a most unusual case of simultaneous bilateral hypertrophies of the parotid gland and masseter muscle originating from the very extensive use of chewing gum.Our extensive literature review uncovered many cases of the independent existence of either masseteric or parotid hypertrop... περισσότερα »
Advanced practice providers improve efficiency and decrease costs in outpatient oral-maxillofacial surgery
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Kimberly M. Daniels, Susan J. Flath-Sporn, Michael Doyle, Ronald Heald, Bonnie L. Padwa PurposeTo determine the effects on time, cost and complication rates of integrating advanced practice providers (APP) into the procedural components of an outpatient oral-maxillofacial surgery practice.MethodsThis is a prospective cohort study of patients from the Department of Plastic and Oral Surgery at Boston Children’s Hospital who underwent removal of 4 impacted thir... περισσότερα »
Maximum Quantity of Bone Available for Harvest from Anterior Iliac Crest, Posterior Iliac Crest and Proximal Tibia Using a Standardized Surgical Approach: A Cadaveric Study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Thomas Burk, Jorge Del Valle, Richard A. Finn, Ceib Phillips PurposeThe three most common sites for obtaining autogenous bone grafts are the anterior iliac crest (AIC), posterior iliac crest (PIC) and proximal tibia (PT). The purpose of this study was to determine the maximum amount of corticocancellous bone that can be harvested from the AIC, PIC and PT when using a standardized surgical approach.Materials and MethodsThe maximum volume of cortical and cancellous bone from th... περισσότερα »
Extraction of Maxillary Teeth Using Articaine without a Palatal Injection: A Comparison Between the Anterior and Posterior Regions of the Maxilla
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Anwar B. Bataineh, Ghamdan A. Al-Sabri IntroductionThe injection of a local anesthesia prior to tooth extraction is always associated with pain, and palatal anesthesia is the most painful injection for the patient.ObjectivesThe specific aims of the study were to evaluate “pain control” using 4% articaine without palatal injection, and to compare adequate anesthesia and pain control in the anterior and posterior regions of the maxilla.MethodsThis prospective controlled study ... περισσότερα »
Clinical management of impacted and transmigrated lower canines
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 40 δευτερόλεπτα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Klaus Sinko, Stefan Nemec, Rudolf Seemann, Christina Eder-Czembirek ObjectivesImpacted, in particular transmigrated lower canines are rare. If they transmigrate, the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, the management and decision making is complex. We developed a decision making flowchart (DMFC) with surgical strategies for the management of impacted lower canines.Materials and MethodsWe investigated 56 patients wit... περισσότερα »
Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
[image: S03785955.gif] Publication date: Available online 22 July 2016 *Source:*Hearing Research Author(s): Min-Hyun Park, Jeong Hun Jang, Jae-Jin Song, Ho Sun Lee, Seung Ha Oh Deafness induces many plastic changes in the auditory neural system. For instance, dendritic changes cause synaptic changes in neural cells. SMI-32, a monoclonal antibody reveals auditory areas and recognizes non-phosphorylated epitopes on medium- and high-molecular-weight subunits of neurofilament proteins in cortical pyramidal neuron dendrites. We investigated SMI-32-immunoreactive (-ir) protein levels in t... περισσότερα »
Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Abstract Hereditary lactate dehydrogenase (LDH) M-subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis-like lesions. We report a third case of pustular psoriasis-like eruptions associated with LDH M-subunit deficiency, which occurred 24 years after the diagnosis of LDH M-subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M-subunit deficiency have antecedent... περισσότερα »
Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] Abstract Adalimumab is a biologic that is very effective for treatment of psoriasis. However, recalcitrant or recurrent lesions sometimes occur during treatment. Maxacalcitol is an active vitamin D3 ointment that is effective in treatment of psoriasis. Topical therapy may be beneficial in treatment of recalcitrant or recurrent lesions during treatment with systemic therapy, but there is little evidence on this topic. We investigated the effect of maxacalcitol on skin lesions during treatment with adalimumab in patients with psoria... περισσότερα »
Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Abstract Severe alopecia areata (AA) can have an unpredictable clinical course and become refractory to contact immunotherapy. Novel treatment options include low-dose interleukin-2 and Janus kinase inhibitors; however, these treatments are still under investigation. Therefore, we evaluated the efficacy and safety of intramuscular (i.m.) triamcinolone acetonide (TAC) as a rescue therapy for refractory AA. We retrospectively analysed efficacy, adverse effects and relapse rate of i.m. TAC monthly in 27 patients with refractory AA. We defined AA as refractory if the patient showed an... περισσότερα »
Topical 5% imiquimod eliminated human papillomavirus 16-associated Bowen's disease
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
http://ift.tt/2a0ebAh
Successful treatment of Kyrle disease with narrowband ultraviolet B
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] http://ift.tt/2anuwT7
Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Abstract Cutaneous mucinoses encompass a variety of cutaneous disorders. Cutaneous focal mucinosis (CFM) was originally described as an asymptomatic solitary lesion characterized by abundant focal cutaneous mucin deposits. However, multiple focal mucinous lesions associated with systemic diseases have also been designated as CFM. Our clinicopathological study of 11 cases of solitary lesions confirmed that CFM is a unique primary cutaneous mucinosis unrelated to mucinosis-associated systemic diseases. We suggest calling this group of CFM lesions "solitary CFM" to distinguish them fr... περισσότερα »
Symptom prevalence in patients with advanced skin cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] Abstract Knowledge of the prevalence of symptoms in patients with incurable cancer in the terminal stage is important for clinicians. However, there has been no report on the prevalence of symptoms in patients with incurable skin cancer. We analyzed the prevalence of symptoms in 224 patients who died due to skin cancer in our center. These data were obtained from medical records compiled by a miscellaneous population of medical staff retrospectively. We evaluated the symptoms at 3 months, 1 month, 2 weeks, 1 week and 3 days before... περισσότερα »
Venous air embolus during prone cervical spine fusion: case report
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Journal of Neurosurgery: Spine, Ahead of Print. Venous air embolism (VAE) is a known neurosurgical complication classically and most frequently occurring in patients undergoing posterior cranial fossa or cervical spine surgery in a sitting or semi-sitting position. The authors present a case of VAE that occurred during posterior cervical spine surgery in a patient in the prone position, a rare intraoperative complication. The patient was a 65-year-old man who was undergoing a C1–2 fusion for a nonunion of a Type II dens fracture and developed a VAE. While VAE in the prone position ... περισσότερα »
Spinal cord anomalies in patients with anorectal malformations without severe sacral abnormalities or meningomyelocele: outcomes after expectant, conservative management
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Journal of Neurosurgery: Spine, Ahead of Print. OBJECTIVE The goal of this study was to determine the significance of spinal cord anomalies (SCAs) in patients with anorectal malformations (ARMs) by comparing the outcomes for bowel function, lower urinary tract symptoms (LUTS), and lower-limb neurological abnormalities to these outcomes in patients with similar ARMs and a normal spinal cord. METHODS The spinal cord MRI records of female patients treated for vestibular and perineal fistula (VF/PF) and male patients with rectourethral fistula (RUF) at a single center between 1983 and ... περισσότερα »
Angiotensin II type 1 receptor dependent GLP-1 and PYY secretion in mice and humans
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/2ahpSVi via IFTTT
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Corrigendum The Journal of Cl... περισσότερα »
Successful treatment of Kyrle disease with narrowband ultraviolet B
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/2anuwT7 via IFTTT
Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions
Abstract Cutaneous mucinoses encompass a variety of cutaneous disorders. Cutaneous focal mucinosis (CFM) was originally described as an asymptomatic solitary lesion characterized by abundant focal cutaneous mucin deposits. However, multiple focal mucinous lesions associated with systemic diseases have also been designated as CFM. Our clinicopathological study of 11 cases of solitary lesions confirmed that CFM is a unique primary cutaneous mucinosis unrelated to mucinosis-associated systemic diseases. We suggest calling this group of CFM lesions "solitary CFM" to distinguish them fr... περισσότερα »
Symptom prevalence in patients with advanced skin cancer
[image: cover.gif?v=1&s=f51958433f8c881f439a7dbf] Abstract Knowledge of the prevalence of symptoms in patients with incurable cancer in the terminal stage is important for clinicians. However, there has been no report on the prevalence of symptoms in patients with incurable skin cancer. We analyzed the prevalence of symptoms in 224 patients who died due to skin cancer in our center. These data were obtained from medical records compiled by a miscellaneous population of medical staff retrospectively. We evaluated the symptoms at 3 months, 1 month, 2 weeks, 1 week and 3 days before... περισσότερα »
Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations
Abstract Autosomal recessive congenital ichthyosis (ARCI) caused by mutations in *CYP4F22* is very rare. CyP4F22, a protein of the cytochrome-P450 family 4, encodes an epidermal ω-hydroxylase decisive for the formation of acylceramides, which is hypothesised to be crucial for skin barrier function. We report a girl with consanguineous parents presenting as collodion baby with contractures of the great joints and palmoplantar hyperlinearity. In the course of the disease she developed fine scaling of the skin with erythroderma, the latter disappearing until the age of six months. He... περισσότερα »
Re-Detection versus New Acquisition of High-Risk Human Papillomavirus in Mid-Adult Women
ABSTRACT To understand high-risk (hr) human papillomavirus (HPV) epidemiology in mid-adulthood, we assessed whether associations between incident detection of hrHPV DNA and recent sexual behavior differed according to whether or not there was serologic evidence of prior infection. From 2011-2012, we enrolled 409 women aged 30-50 years into a 6-month longitudinal study. We collected health and sexual behavior histories, enrollment sera for HPV antibody testing, and monthly self-collected vaginal swabs for HPV DNA genotyping. Generalized estimating equations logistic regression ident... περισσότερα »
Postmenopausal breast cancer risk and interactions between body mass index, menopausal hormone therapy use, and vitamin D supplementation: Evidence from the E3N cohort
Abstract Experimental studies suggest protective effects of vitamin D on breast carcinogenesis, but epidemiological evidence is not conclusive. Body mass index (BMI) has been shown to modulate the effect of supplementation on the vitamin D status, but its potential influence on the relationship with breast cancer risk has been little studied. We investigated a potential interaction between BMI and vitamin D supplementation on breast cancer risk while considering an already reported interaction between vitamin D supplementation and menopausal hormone therapy (MHT) use. Vitamin D su... περισσότερα »
Systematic review and meta-analysis of the risk of severe and life-threatening thromboembolism in cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab)
Abstract Cancer-associated thromboembolism is a substantial problem in clinical practice. An increase in the level of fibrinopeptide A (a substance associated with hypercoagulable states) has been observed in humans exposed to fluorouracil. Anti-EGFR monoclonal antibodies cetuximab and panitumumab, which are now widely used in patients with metastatic colorectal cancer, could prolong the uncovering of endothelial structures resulting from flouorouracil or other co-administered agents, thus favouring several factors leading to thromboembolism. We performed a systematic review and ... περισσότερα »
Simultaneous Bilateral Hypertrophies of The Parotid Gland and Masseter Muscle: Case Report
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Rohan Prabhu, Louis Mandel Increased salivary demand can lead to enlarged parotid salivary glands, while increased activity of the masseter muscles will cause masseter hypertrophy. The authors report a most unusual case of simultaneous bilateral hypertrophies of the parotid gland and masseter muscle originating from the very extensive use of chewing gum.Our extensive literature review uncovered many cases of the independent existence of either masseteric or parotid hypertrop... περισσότερα »
Clinical Pathway Implementation Improves Efficiency of Care in a Maxillofacial Head and Neck Surgery Unit
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Jacob G. Yetzer, Phillip Pirgousis, Zhuo Li, Rui Fernandes PurposeClinical pathways have become an important and simple method of improving patient outcomes while reducing healthcare resource utilization. The purpose of this study was to evaluate the early outcomes associated with the implementation of a clinical pathway within a Maxillofacial Head and Neck Surgery unit.Materials and MethodsThis investigation is a retrospective cohort study of patients who underwent microvasc... περισσότερα »
Extraction of Maxillary Teeth Using Articaine without a Palatal Injection: A Comparison Between the Anterior and Posterior Regions of the Maxilla
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Anwar B. Bataineh, Ghamdan A. Al-Sabri IntroductionThe injection of a local anesthesia prior to tooth extraction is always associated with pain, and palatal anesthesia is the most painful injection for the patient.ObjectivesThe specific aims of the study were to evaluate "pain control" using 4% articaine without palatal injection, and to compare adequate anesthesia and pain control in the anterior and posterior regions of the maxilla.MethodsThis prospective controlled study ... περισσότερα »
Maximum Quantity of Bone Available for Harvest from Anterior Iliac Crest, Posterior Iliac Crest and Proximal Tibia Using a Standardized Surgical Approach: A Cadaveric Study
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Thomas Burk, Jorge Del Valle, Richard A. Finn, Ceib Phillips PurposeThe three most common sites for obtaining autogenous bone grafts are the anterior iliac crest (AIC), posterior iliac crest (PIC) and proximal tibia (PT). The purpose of this study was to determine the maximum amount of corticocancellous bone that can be harvested from the AIC, PIC and PT when using a standardized surgical approach.Materials and MethodsThe maximum volume of cortical and cancellous bone from th... περισσότερα »
Clinical management of impacted and transmigrated lower canines
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Klaus Sinko, Stefan Nemec, Rudolf Seemann, Christina Eder-Czembirek ObjectivesImpacted, in particular transmigrated lower canines are rare. If they transmigrate, the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, the management and decision making is complex. We developed a decision making flowchart (DMFC) with surgical strategies for the management of impacted lower canines.Materials and MethodsWe investigated 56 patients wit... περισσότερα »
Advanced practice providers improve efficiency and decrease costs in outpatient oral-maxillofacial surgery
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Kimberly M. Daniels, Susan J. Flath-Sporn, Michael Doyle, Ronald Heald, Bonnie L. Padwa PurposeTo determine the effects on time, cost and complication rates of integrating advanced practice providers (APP) into the procedural components of an outpatient oral-maxillofacial surgery practice.MethodsThis is a prospective cohort study of patients from the Department of Plastic and Oral Surgery at Boston Children’s Hospital who underwent removal of 4 impacted third ... περισσότερα »
Simultaneous Bilateral Hypertrophies of The Parotid Gland and Masseter Muscle: Case Report
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Rohan Prabhu, Louis Mandel Increased salivary demand can lead to enlarged parotid salivary glands, while increased activity of the masseter muscles will cause masseter hypertrophy. The authors report a most unusual case of simultaneous bilateral hypertrophies of the parotid gland and masseter muscle originating from the very extensive use of chewing gum.Our extensive literature review uncovered many cases of the independent existence of either masseteric or parotid hypertrophy... περισσότερα »
Clinical Pathway Implementation Improves Efficiency of Care in a Maxillofacial Head and Neck Surgery Unit
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Jacob G. Yetzer, Phillip Pirgousis, Zhuo Li, Rui Fernandes PurposeClinical pathways have become an important and simple method of improving patient outcomes while reducing healthcare resource utilization. The purpose of this study was to evaluate the early outcomes associated with the implementation of a clinical pathway within a Maxillofacial Head and Neck Surgery unit.Materials and MethodsThis investigation is a retrospective cohort study of patients who underwent microvascul... περισσότερα »
Extraction of Maxillary Teeth Using Articaine without a Palatal Injection: A Comparison Between the Anterior and Posterior Regions of the Maxilla
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Anwar B. Bataineh, Ghamdan A. Al-Sabri IntroductionThe injection of a local anesthesia prior to tooth extraction is always associated with pain, and palatal anesthesia is the most painful injection for the patient.ObjectivesThe specific aims of the study were to evaluate "pain control" using 4% articaine without palatal injection, and to compare adequate anesthesia and pain control in the anterior and posterior regions of the maxilla.MethodsThis prospective controlled study fo... περισσότερα »
Maximum Quantity of Bone Available for Harvest from Anterior Iliac Crest, Posterior Iliac Crest and Proximal Tibia Using a Standardized Surgical Approach: A Cadaveric Study
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Thomas Burk, Jorge Del Valle, Richard A. Finn, Ceib Phillips PurposeThe three most common sites for obtaining autogenous bone grafts are the anterior iliac crest (AIC), posterior iliac crest (PIC) and proximal tibia (PT). The purpose of this study was to determine the maximum amount of corticocancellous bone that can be harvested from the AIC, PIC and PT when using a standardized surgical approach.Materials and MethodsThe maximum volume of cortical and cancellous bone from the ... περισσότερα »
Clinical management of impacted and transmigrated lower canines
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Klaus Sinko, Stefan Nemec, Rudolf Seemann, Christina Eder-Czembirek ObjectivesImpacted, in particular transmigrated lower canines are rare. If they transmigrate, the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, the management and decision making is complex. We developed a decision making flowchart (DMFC) with surgical strategies for the management of impacted lower canines.Materials and MethodsWe investigated 56 patients with ... περισσότερα »
Vascularized lymph node transfer from thoracodorsal axis for congenital and post filarial lymphedema of the lower limb
Vascularized lymph node transfer is becoming a popular method to treat lymphedema. We have performed vascularized lymph node transfer for two patients, one with congenital and the other with post filarial lymphedema of the lower limb. Lymph node transfer was performed from the thoracodorsal axis. Both cases exhibited improved results in both limb circumference and quality of life measurements. *J. Surg. Oncol*. © 2016 Wiley Periodicals, Inc. from Cancer via ola Kala on Inoreader http://ift.tt/2a0A4n6 via IFTTT
Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer
Background and Objectives Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). Methods Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). Results Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the... περισσότερα »
The use of supraclavicular free flap with vascularized lymph node transfer for treatment of lymphedema: A prospective study of 100 consecutive cases
Background and Objectives Vascularized lymph node transfer (VLNT) is gaining popularity for treatment of lymphedema. The purpose of this study was to evaluate the flap and the donor site morbidity of the supraclavicular (SC) VLNT. Methods A review of a prospective database was performed for patients who had undergone SC VLNT to treat upper or lower extremity lymphedema. Flap and donor site complications were registered for each patient. A detailed technical surgical approach is explained. Results One hundred consecutive patients with lower or upper extremity lymphedema underwen... περισσότερα »
lncRNA-GCASPC suppresses GBC progression
Long non-coding RNAs (lncRNAs) are being implicated in the development of many cancers. Here we report the discovery of a critical role for the lncRNA GCASPC in determining the progression of gallbladder cancer (GBC). Differentially expressed lncRNAs and mRNAs between GBC specimens and paired adjacent non-tumor tissues from 5 patients were identified by and validated by an expression microarray analysis. qRT-PCR was used to measure GCASPC levels in tissues from 42 GBC patients, and levels of GCASPC were confirmed further in a separate cohort of 89 GBC patients. GCASPC was overexpre... περισσότερα »
JNK modulates EGFR/HER2 targeted therapy acquired resistance
Resistance limits the effectiveness of receptor tyrosine kinase (RTK)-targeted therapies. Combination therapies targeting resistance mechanisms can considerably improve response, but will require an improved understanding of when particular combinations will be effective. One common form of resistance is bypass signaling, wherein RTKs not targeted by an inhibitor can direct reactivation of pathways essential for survival. While this mechanism of resistance is well appreciated, it is unclear which downstream signaling events are responsible. Here, we apply a combined experimental- ... περισσότερα »
{alpha}v{beta}6 integrin activates androgen receptor
Androgen receptor signaling fuels prostate cancer and is a major therapeutic target. However, mechanisms of resistance to therapeutic androgen ablation are not well understood. Here, using a prostate cancer mouse model, Ptenpc-/-, carrying a prostate epithelial-specific Pten deletion, we show that the αvβ6 integrin is required for tumor growth in vivo of castrated as well as of non-castrated mice. We describe a novel signaling pathway that couples the αvβ6 integrin cell surface receptor to androgen receptor via activation of JNK1 and causes increased nuclear localization and activ... περισσότερα »
Re-Detection versus New Acquisition of High-Risk Human Papillomavirus in Mid-Adult Women
ABSTRACT To understand high-risk (hr) human papillomavirus (HPV) epidemiology in mid-adulthood, we assessed whether associations between incident detection of hrHPV DNA and recent sexual behavior differed according to whether or not there was serologic evidence of prior infection. From 2011-2012, we enrolled 409 women aged 30-50 years into a 6-month longitudinal study. We collected health and sexual behavior histories, enrollment sera for HPV antibody testing, and monthly self-collected vaginal swabs for HPV DNA genotyping. Generalized estimating equations logistic regression ident... περισσότερα »
Postmenopausal breast cancer risk and interactions between body mass index, menopausal hormone therapy use, and vitamin D supplementation: Evidence from the E3N cohort
Abstract Experimental studies suggest protective effects of vitamin D on breast carcinogenesis, but epidemiological evidence is not conclusive. Body mass index (BMI) has been shown to modulate the effect of supplementation on the vitamin D status, but its potential influence on the relationship with breast cancer risk has been little studied. We investigated a potential interaction between BMI and vitamin D supplementation on breast cancer risk while considering an already reported interaction between vitamin D supplementation and menopausal hormone therapy (MHT) use. Vitamin D su... περισσότερα »
Systematic review and meta-analysis of the risk of severe and life-threatening thromboembolism in cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab)
Abstract Cancer-associated thromboembolism is a substantial problem in clinical practice. An increase in the level of fibrinopeptide A (a substance associated with hypercoagulable states) has been observed in humans exposed to fluorouracil. Anti-EGFR monoclonal antibodies cetuximab and panitumumab, which are now widely used in patients with metastatic colorectal cancer, could prolong the uncovering of endothelial structures resulting from flouorouracil or other co-administered agents, thus favouring several factors leading to thromboembolism. We performed a systematic review and ... περισσότερα »
Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Neurosurgery, Ahead of Print. The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergo... περισσότερα »
Letter to the Editor: Should osseointegration be a target to achieve during cranioplasty?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Neurosurgery, Ahead of Print. http://ift.tt/2ahsrGJ
Microelectrode recording findings within the tractography-defined ventral intermediate nucleus
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Neurosurgery, Ahead of Print. OBJECTIVE The ventral intermediate nucleus (VIM) of the thalamus is not visible on structural MRI. Therefore, direct VIM targeting methods for stereotactic tremor surgery are desirable. The authors previously described a direct targeting method for visualizing the VIM and its structural connectivity using deterministic tractography. In this combined electrophysiology and imaging study, the authors investigated the electrophysiology within this tractography-defined VIM (T-VIM). METHODS Thalamic neurons were classified based on their relative ... περισσότερα »
Interhospital transfer of pediatric neurosurgical patients
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The purpose of this study was to describe patterns of transfer, resource utilization, and clinical outcomes associated with the interhospital transfer of pediatric neurosurgical patients. METHODS All consecutive, prospectively collected requests for interhospital patient transfer to the pediatric neurosurgical service at Texas Children's Hospital were retrospectively analyzed from October 2013 to September 2014. Demographic patient information, resource utilization, and outcomes were recorded and compared across predefi... περισσότερα »
Posters Presented at the 19th Joint Meeting of the International Society of Dermatopathology, March 2–3, 2016, Hilton Crystal City at Washington Reagan National Airport, Arlington, Virginia, USA
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a4NAAE via IFTTT
Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis
Abstract: Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review… Continue reading Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis
A Progressive Blistering Eruption in a 5-Month-Old Male Infant
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a3lIPR via IFTTT
Polarized Microscopy in Lesions With Altered Dermal Collagen
Abstract: Alterations in dermal collagen are noted in dermatofibroma, dermatofibrosarcoma protuberans, morphea, lichen sclerosus et atrophicus, hypertrophic scars, and keloids. The authors sought to determine whether variations in birefringence of collagen by polarized microscopy could be of help in diagnosing such conditions. Representative hematoxylin and eosin sections of 400 cases, including dermatofibroma, dermatofibrosarcoma protuberans, hypertrophic… Continue reading Polarized Microscopy in Lesions With Altered Dermal Collagen
NRAS Status in Giant Melanocytic Nevus With Metastatic Melanoma
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2aiMQwZ via IFTTT
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations
Abstract: Hidradenoma papilliferum (HP), also known as papillary hidradenoma, is the most common benign lesion of the female anogenital area derived from anogenital mammary-like glands (AGMLG). HP can be viewed conceptually as the cutaneous counterpart of mammary intraductal papilloma. The authors have studied 264 cases of HP, detailing various changes in the tumor and adjacent… Continue reading Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations
Decomposing mechanisms of abnormal saccade generation in schizophrenia patients: Contributions of volitional initiation, motor preparation, and fixation release
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Clinical and theoretical models suggest deficient volitional initiation of action in schizophrenia patients. Recent research provided an experimental model of testing this assumption using saccade tasks. However, inconsistent findings necessitate a specification of conditions on which the deficit may occur. The present study sought to detect mechanisms that may contribute to poor performance. Sixteen schizophrenia patients and 16 healthy control participants performed visually guided and two types of volitional saccade tasks. All tasks varied as to whether the initial fixa... περισσότερα »
Cardiac cycle time effects on selection efficiency in vision
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract The effect of cardiac cycle time on attentional selection was investigated in an experiment in which participants classified target letters in a visual selection task. Stimulus onsets were aligned to the R wave of the electrocardiogram and stimuli presented either during the ventricular systole or diastole. Selection efficiency was operationalized as difference in target selection performance under conditions of homogeneous and heterogeneous distractors. Differences in performance (i.e., the impact selection difficulty had on the ability to select the target) were attenua... περισσότερα »
Sleep and sleepiness in environmental intolerances: a population- based study
[image: S13899457.gif] Publication date: Available online 21 July 2016 *Source:*Sleep Medicine Author(s): Maria Nordin, Steven Nordin BackgroundAbout one fourth of the general population report environmental intolerance (EI) to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMFs) and/or sounds. EI sufferers show various clinical features, of which sleep disturbance is one. Sleep disturbance is common also in the general population, but it is not known whether the disturbance is more prominent in EI sufferers than in individuals who do not experience EI . There... περισσότερα »
Advanced practice providers improve efficiency and decrease costs in outpatient oral-maxillofacial surgery
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Kimberly M. Daniels, Susan J. Flath-Sporn, Michael Doyle, Ronald Heald, Bonnie L. Padwa PurposeTo determine the effects on time, cost and complication rates of integrating advanced practice providers (APP) into the procedural components of an outpatient oral-maxillofacial surgery practice.MethodsThis is a prospective cohort study of patients from the Department of Plastic and Oral Surgery at Boston Children's Hospital who underwent removal of 4 impacted thir... περισσότερα »
Simultaneous Bilateral Hypertrophies of The Parotid Gland and Masseter Muscle: Case Report
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Rohan Prabhu, Louis Mandel Increased salivary demand can lead to enlarged parotid salivary glands, while increased activity of the masseter muscles will cause masseter hypertrophy. The authors report a most unusual case of simultaneous bilateral hypertrophies of the parotid gland and masseter muscle originating from the very extensive use of chewing gum.Our extensive literature review uncovered many cases of the independent existence of either masseteric or parotid hypertrop... περισσότερα »
Clinical Pathway Implementation Improves Efficiency of Care in a Maxillofacial Head and Neck Surgery Unit
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Jacob G. Yetzer, Phillip Pirgousis, Zhuo Li, Rui Fernandes PurposeClinical pathways have become an important and simple method of improving patient outcomes while reducing healthcare resource utilization. The purpose of this study was to evaluate the early outcomes associated with the implementation of a clinical pathway within a Maxillofacial Head and Neck Surgery unit.Materials and MethodsThis investigation is a retrospective cohort study of patients who underwent microvasc... περισσότερα »
Extraction of Maxillary Teeth Using Articaine without a Palatal Injection: A Comparison Between the Anterior and Posterior Regions of the Maxilla
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Anwar B. Bataineh, Ghamdan A. Al-Sabri IntroductionThe injection of a local anesthesia prior to tooth extraction is always associated with pain, and palatal anesthesia is the most painful injection for the patient.ObjectivesThe specific aims of the study were to evaluate "pain control" using 4% articaine without palatal injection, and to compare adequate anesthesia and pain control in the anterior and posterior regions of the maxilla.MethodsThis prospective controlled study ... περισσότερα »
Maximum Quantity of Bone Available for Harvest from Anterior Iliac Crest, Posterior Iliac Crest and Proximal Tibia Using a Standardized Surgical Approach: A Cadaveric Study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 21 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Thomas Burk, Jorge Del Valle, Richard A. Finn, Ceib Phillips PurposeThe three most common sites for obtaining autogenous bone grafts are the anterior iliac crest (AIC), posterior iliac crest (PIC) and proximal tibia (PT). The purpose of this study was to determine the maximum amount of corticocancellous bone that can be harvested from the AIC, PIC and PT when using a standardized surgical approach.Materials and MethodsThe maximum volume of cortical and cancellous bone from th... περισσότερα »
Clinical management of impacted and transmigrated lower canines
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 22 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Klaus Sinko, Stefan Nemec, Rudolf Seemann, Christina Eder-Czembirek ObjectivesImpacted, in particular transmigrated lower canines are rare. If they transmigrate, the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, the management and decision making is complex. We developed a decision making flowchart (DMFC) with surgical strategies for the management of impacted lower canines.Materials and MethodsWe investigated 56 patients wit... περισσότερα »
Letter to the Editor: Should osseointegration be a target to achieve during cranioplasty?
Journal of Neurosurgery, Ahead of Print. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2ahsrGJ via IFTTT
Microelectrode recording findings within the tractography-defined ventral intermediate nucleus
Journal of Neurosurgery, Ahead of Print. OBJECTIVE The ventral intermediate nucleus (VIM) of the thalamus is not visible on structural MRI. Therefore, direct VIM targeting methods for stereotactic tremor surgery are desirable. The authors previously described a direct targeting method for visualizing the VIM and its structural connectivity using deterministic tractography. In this combined electrophysiology and imaging study, the authors investigated the electrophysiology within this tractography-defined VIM (T-VIM). METHODS Thalamic neurons were classified based on their relative ... περισσότερα »
Interhospital transfer of pediatric neurosurgical patients
Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The purpose of this study was to describe patterns of transfer, resource utilization, and clinical outcomes associated with the interhospital transfer of pediatric neurosurgical patients. METHODS All consecutive, prospectively collected requests for interhospital patient transfer to the pediatric neurosurgical service at Texas Children's Hospital were retrospectively analyzed from October 2013 to September 2014. Demographic patient information, resource utilization, and outcomes were recorded and compared across predefi... περισσότερα »
Decomposing mechanisms of abnormal saccade generation in schizophrenia patients: Contributions of volitional initiation, motor preparation, and fixation release
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Clinical and theoretical models suggest deficient volitional initiation of action in schizophrenia patients. Recent research provided an experimental model of testing this assumption using saccade tasks. However, inconsistent findings necessitate a specification of conditions on which the deficit may occur. The present study sought to detect mechanisms that may contribute to poor performance. Sixteen […]
Cardiac cycle time effects on selection efficiency in vision
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The effect of cardiac cycle time on attentional selection was investigated in an experiment in which participants classified target letters in a visual selection task. Stimulus onsets were aligned to the R wave of the electrocardiogram and stimuli presented either during the ventricular systole or diastole. Selection efficiency was operationalized as difference in target […]
Re-Detection versus New Acquisition of High-Risk Human Papillomavirus in Mid-Adult Women
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT To understand high-risk (hr) human papillomavirus (HPV) epidemiology in mid-adulthood, we assessed whether associations between incident detection of hrHPV DNA and recent sexual behavior differed according to whether or not there was serologic evidence of prior infection. From 2011-2012, we enrolled 409 women aged 30-50 years into a 6-month longitudinal study. We collected health […]
Postmenopausal breast cancer risk and interactions between body mass index, menopausal hormone therapy use, and vitamin D supplementation: Evidence from the E3N cohort
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Experimental studies suggest protective effects of vitamin D on breast carcinogenesis, but epidemiological evidence is not conclusive. Body mass index (BMI) has been shown to modulate the effect of supplementation on the vitamin D status, but its potential influence on the relationship with breast cancer risk has been little studied. We investigated a potential […]
Systematic review and meta-analysis of the risk of severe and life-threatening thromboembolism in cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Cancer-associated thromboembolism is a substantial problem in clinical practice. An increase in the level of fibrinopeptide A (a substance associated with hypercoagulable states) has been observed in humans exposed to fluorouracil. Anti-EGFR monoclonal antibodies cetuximab and panitumumab, which are now widely used in patients with metastatic colorectal cancer, could prolong the uncovering of endothelial […]
Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Autosomal recessive congenital ichthyosis (ARCI) caused by mutations in CYP4F22 is very rare. CyP4F22, a protein of the cytochrome-P450 family 4, encodes an epidermal ω-hydroxylase decisive for the formation of acylceramides, which is hypothesised to be crucial for skin barrier function. We report a girl with consanguineous parents presenting as collodion baby with contractures […]
Close encounter! Zika virus found alive in sperm after record 93 days – Economic Times
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Close encounter! Zika virus found alive in sperm after record 93 days Economic Times Alcohol causes seven types of cancer. IANS|. Jul 23, 2016, 10.15 AM IST. Evidence can support the judgement that alcohol causes cancer of the oropharynx, larynx, oesophagus, liver, colon, rectum & breast. WELLINGTON: Excessive consumption of alcohol … and more » […]
Protective effects of physical exercise on MDMA-induced cognitive and mithochondrial impairment
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 21 July 2016 Source:Free Radical Biology and Medicine Author(s): Ghorban Taghizadeh, Jalal Pourahmad, Hajar Mehdizadeh, Alireza Foroumadi, Anahita Torkaman-Boutorabi, Shokoufeh Hassani, Parvaneh Naserzadeh, Reyhaneh Shariatmadari, Mahdi Gholami, Mohammad Reza Rouini, Mohammad Sharifzadeh Debate continues about the effect of 3, 4-methylenedioxymethamphetamine (MDMA) on cognitive and mitochondrial function through the CNS. It has […]
Cornoid Lamellation Associated With Lichen Sclerosus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a7y5L6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Histological Features, p53, c-Kit, and Poliomavirus Status and Impact on Survival in Merkel Cell Carcinoma Patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Merkel cell carcinoma (MCC) is a rare and aggressive malignancy from neuroendocrine cells in the skin. Despite being one of the most life-threatening of skin cancers, little is known about the potential signaling mechanism that drives carcinogenesis in MCC. The purpose of this study is to assess the impact of Merkel cell polyomavirus (MCPyV), […]
Quantifying PM2.5-meteorology sensitivities in a global climate model
[image: S13522310.gif] Publication date: October 2016 *Source:*Atmospheric Environment, Volume 142 Author(s): D.M. Westervelt, L.W. Horowitz, V. Naik, A.P.K. Tai, A.M. Fiore, D.L. Mauzerall Climate change can influence fine particulate matter concentrations (PM2.5) through changes in air pollution meteorology. Knowledge of the extent to which climate change can exacerbate or alleviate air pollution in the future is needed for robust climate and air pollution policy decision-making. To examine the influence of climate on PM2.5, we use the Geophysical Fluid Dynamics Laboratory Coupled... περισσότερα »
Deriving aerosol hygroscopic mixing state from size-resolved CCN activity and HR-ToF-AMS measurements
[image: S13522310.gif] Publication date: October 2016 *Source:*Atmospheric Environment, Volume 142 Author(s): Deepika Bhattu, S.N. Tripathi, Abhishek Chakraborty The ability of a particle to uptake water and form a cloud droplet depends on its hygroscopicity. To understand its impact on cloud properties and ultimately radiative forcing, knowledge of chemically-resolved mixing state information or the one based on hygroscopic growth is crucial. Typically, global models assume either pure internal or external mixing state which might not be true for all conditions and sampling location... περισσότερα »
Application of mobile sampling to investigate spatial variation in fine particle composition
[image: alertIcon.gif] Publication date: October 2016 *Source:*Atmospheric Environment, Volume 142 Author(s): Hugh Z. Li, Timothy R. Dallmann, Peishi Gu, Albert A. Presto Long-term exposure to particulate matter (PM) is a major contributor to air pollution related deaths. Evidence indicates that metals play an important role in harming human health due to their redox potential. We conducted a mobile sampling campaign in 2013 summer and winter in Pittsburgh, PA to characterize spatial variation in PM2.5 mass and composition. Thirty-six sites were chosen based on three stratification v... περισσότερα »
Impact of ENSO on variability of AIRS retrieved CO2 over India
Publication date: October 2016 *Source:*Atmospheric Environment, Volume 142 Author(s): K. Ravi Kumar, Yogesh K. Tiwari, J.V. Revadekar, Ramesh Vellore, Tania Guha This study investigates the impact of ENSO on the CO2 variability over the Indian subcontinent for the period 2003–2011 based on the relationships between NINO indices derived from the sea surface temperature (SST) and AIRS-retrieved mid-tropospheric CO2 concentrations. The NINO4 region exhibits positive influence on the variability of CO2 almost during the entire year except for the post-monsoon/winter months (October throu... περισσότερα »
Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Autosomal recessive congenital ichthyosis (ARCI) caused by mutations in *CYP4F22* is very rare. CyP4F22, a protein of the cytochrome-P450 family 4, encodes an epidermal ω-hydroxylase decisive for the formation of acylceramides, which is hypothesised to be crucial for skin barrier function. We report a girl with consanguineous parents presenting as collodion baby with contractures of the great joints and palmoplantar hyperlinearity. In the course of the disease she developed fine scaling of the skin with erythroderma, the latter disappearing until the age of six months. He... περισσότερα »
Angiotensin II type 1 receptor dependent GLP-1 and PYY secretion in mice and humans
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Endocrinology, Early Release. http://ift.tt/2ahpSVi
Calcium-sensing receptor and breast cancer
Parathyroid hormone-related protein (PTHrP) contributes to the development and metastatic progression of breast cancer by promoting hypercalcemia, but it is not known how PTHrP is upregulated during breast tumorigenesis. Here we report a central role in this process for CaSR, a calcium-sensing receptor which enables cellular responses to changes in extracellular calcium, through studies of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in human breast cancer cells. CaSR activation stimulated PTHrP production by breast cancer cells in vitro and... περισσότερα »
Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation
Publication date: September 2016 *Source:*European Journal of Cancer, Volume 65 Author(s): Guoqing Qian, Dongsheng Wang, Kelly R. Magliocca, Zhongliang Hu, Sreenivas Nannapaneni, Sungjin Kim, Zhengjia Chen, Shi-Yong Sun, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen PurposeHuman papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) carries a distinct clinical behaviour. c-Met oncogene is an important driver for tumour progression and its relationship with HPV in OPSCC was explored in the present study.Experimental designKnockdown of HPV oncogene E6 or p53 alone a... περισσότερα »
Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy
Publication date: September 2016 *Source:*European Journal of Cancer, Volume 65 Author(s): Laurent Dercle, Samy Ammari, Stéphane Champiat, Christophe Massard, Charles Ferté, Lokmane Taihi, Romain-David Seban, Sandrine Aspeslagh, Linda Mahjoubi, Nyam Kamsu-Kom, Caroline Robert, Aurélien Marabelle, Martin Schlumberger, Jean-Charles Soria, Sophie Postel-Vinay BackgroundDrugs targeting programmed death receptor-1 (PD-1) and its ligand PD-L1 have shown activity in multiple malignancies. Considering their novel mechanism of action, whether traditional prognostic scores also apply to patie... περισσότερα »
Abstracts Presented at the 19th Joint Meeting of the International Society of Dermatopathology, March 2–3, 2016, Hilton Crystal City at Washington Reagan National Airport, Arlington, Virginia, USA
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2akqk3w via IFTTT
Sleep and sleepiness in environmental intolerances: a population- based study
Publication date: Available online 21 July 2016 Source:Sleep Medicine Author(s): Maria Nordin, Steven Nordin BackgroundAbout one fourth of the general population report environmental intolerance (EI) to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMFs) and/or sounds. EI sufferers show various clinical features, of which sleep disturbance is one. Sleep disturbance is common also in the general… Continue reading Sleep and sleepiness in environmental intolerances: a population- based study
Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid: A “Binocle” Presentation of the “Monocle Tumor”
Abstract: Primary cutaneous signet-ring cell carcinoma is a rare and aggressive neoplasm which diffusely involves dermis and subcutis of the eyelid or axillae. Neoplastic cells show a signet-ring cell or histiocytoid morphology in variable number, and can be found intermingled among collagen bundles, sparing the epidermis. This neoplasm typically appears in the eyelids of elderly… Continue reading Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid: A “Binocle” Presentation of the “Monocle Tumor”
Sleep and sleepiness in environmental intolerances: a population- based study
Publication date: Available online 21 July 2016 Source:Sleep Medicine Author(s): Maria Nordin, Steven Nordin BackgroundAbout one fourth of the general population report environmental intolerance (EI) to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMFs) and/or sounds. EI sufferers show various clinical features, of which sleep disturbance is one. Sleep disturbance is common also in the general… Continue reading Sleep and sleepiness in environmental intolerances: a population- based study
Rosacea-Like Leukemia Cutis: A Case Report
Abstract: Leukemia cutis describes the infiltration and dissemination of neoplastic leukemic cells into the epidermis, dermis, or subcutis, resulting in clinically identifiable cutaneous lesions. Depending on the type of leukemia, a wide range of clinical and histopathological findings may be encountered. This report describes a patient with a rosacea-like eruption as a unique clinical presentation… Continue reading Rosacea-Like Leukemia Cutis: A Case Report
JNK modulates EGFR/HER2 targeted therapy acquired resistance
Resistance limits the effectiveness of receptor tyrosine kinase (RTK)-targeted therapies. Combination therapies targeting resistance mechanisms can considerably improve response, but will require an improved understanding of when particular combinations will be effective. One common form of resistance is bypass signaling, wherein RTKs not targeted by an inhibitor can direct reactivation of pathways essential for survival.… Continue reading JNK modulates EGFR/HER2 targeted therapy acquired resistance
{alpha}v{beta}6 integrin activates androgen receptor
Androgen receptor signaling fuels prostate cancer and is a major therapeutic target. However, mechanisms of resistance to therapeutic androgen ablation are not well understood. Here, using a prostate cancer mouse model, Ptenpc-/-, carrying a prostate epithelial-specific Pten deletion, we show that the αvβ6 integrin is required for tumor growth in vivo of castrated as well… Continue reading {alpha}v{beta}6 integrin activates androgen receptor
Calcium-sensing receptor and breast cancer
Parathyroid hormone-related protein (PTHrP) contributes to the development and metastatic progression of breast cancer by promoting hypercalcemia, but it is not known how PTHrP is upregulated during breast tumorigenesis. Here we report a central role in this process for CaSR, a calcium-sensing receptor which enables cellular responses to changes in extracellular calcium, through studies of… Continue reading Calcium-sensing receptor and breast cancer
Computed Tomography Findings Associated with Clinical Outcome After Dynamic Posterior Stabilization of the Lumbar Spine
Publication date: September 2016 Source:World Neurosurgery, Volume 93 Author(s): Benedikt J. Schwaiger, Michael Behr, Alexandra S. Gersing, Bernhard Meyer, Claus Zimmer, Jan S. Kirschke, Yu-Mi Ryang, Florian Ringel ObjectiveTo evaluate whether preoperative multirow detector computed tomography (MDCT) findings were associated with clinical outcome 24 months after dynamic stabilization for painful degenerative lumbar spine disease.MethodsPreoperative MDCT… Continue reading Computed Tomography Findings Associated with Clinical Outcome After Dynamic Posterior Stabilization of the Lumbar... περισσότερα »
Sleep and sleepiness in environmental intolerances: a population- based study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Publication date: Available online 21 July 2016Source:Sleep Medicine Author(s): Maria Nordin, Steven Nordin BackgroundAbout one fourth of the general population report environmental intolerance (EI) to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMFs) and/or sounds. EI sufferers show various clinical features, of which sleep disturbance is one. Sleep disturbance is common also in the general population, […]
