Anesthetic management of a patient with polycythemia vera for neurosurgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Anesthetic management of a patient with polycythemia vera for neurosurgery: Abstract Polycythemia vera (PV) is a myeloproliferative disorder characterized by excess red cell clonality. The increased number of red blood cells can lead to increased viscosity of the blood and ultimately compromise the blood supply to the end organs. Thromboembolic and hemorrhagic complications can also […]
Thirty-Day Hospital Revisit Rates in Patients Undergoing Septorhinoplasty
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Thirty-Day Hospital Revisit Rates in Patients Undergoing Septorhinoplasty: This cohort analysis uses data from the Healthcare Cost and Utilization Project databases to determine the rate of 30-day hospital revisits following septorhinoplasty and the risk factors associated with revisits. Importance Estimates of the 30-day hospital revisit rate following septorhinoplasty and the risk factors associated with revisits […]
Eyelid Position in Facial Nerve Palsy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Eyelid Position in Facial Nerve Palsy: This retrospective cohort study describes eyelid malposition in facial nerve palsy. Importance Understanding the prevalence and clinical features of eyelid malpositions in facial nerve palsy (FNP) may inform proper management of patients with FNP and supplement our knowledge of eyelid physiology. Objective To describe eyelid malposition in FNP. Design, […]
Filler Enhancement of the Superior Periocular Area
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Filler Enhancement of the Superior Periocular Area: This Surgery Pearl reports that detailed knowledge of anatomy and careful placement of hyaluronic acid filler can be used to restore volume to the eyebrow, forehead, and superior sulcus to improve appearance and patient satisfaction. This Surgery Pearl reports that detailed knowledge of anatomy and careful placement of […]
Transposition of the Intratemporal Facial to Hypoglossal Nerve : Reanimation of the Paralyzed Face
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Reanimation of the Paralyzed Face: This case series examines the outcomes of the transposition of the infratemeporal facial nerve for end-to-side coaptation to the hypoglossal nerve for facial reanimation and reinnervation. Importance The hypoglossal nerve has long been an axonal source for reinnervation of the paralyzed face. In this study, we report our experience with […]
Plastic reconstructive surgery techniques for defect coverage of extended skull base defects
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Plastic reconstructive surgery techniques for defect coverage of extended skull base defects: Large skull base defects are extremely difficult to treat and have a severe impact on patients’ physical appearance and functional aspects. These extensive defect zones are mainly caused by trauma, surgical interventions or wide tumor excision. High-level microsurgical techniques are necessary in order […]
A Smart-Home System to Unobtrusively and Continuously Assess Loneliness in Older Adults
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
A Smart-Home System to Unobtrusively and Continuously Assess Loneliness in Older Adults: Loneliness is a common condition in older adults and is associated with increased morbidity and mortality, decreased sleep quality, and increased risk of cognitive decline. Assessing loneliness in older adults is challenging due to the negative desirability biases associated with being lonely. Thus, […]
Sensitive detection of Porphyromonas gingivalis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Sensitive detection of Porphyromonas gingivalis based on magnetic capture and upconversion fluorescent identification with multifunctional nanospheres: A specific and sensitive detection system was designed to detect Porphyromonas gingivalis, a major periodontal pathogen, in mixed bacterial fluids. This new detection system was based on the use of fluorescent and magnetic encoding nanospheres that were conjugated with […]
Lipoma of the parotid gland after trauma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
: a case report and review via British Journal of Oral and Maxillofacial Surgery Source:British Journal of Oral and Maxillofacial SurgeryAuthor(s): Satnam Singh Rehal, Mustansir Alibhai, Esther Perera http://ift.tt/28WKa5V
Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells: Bisphosphonates are commonly used to treat malignant tumours that originate in bone. In recent years, with the widespread application of these drugs in chemotherapy, reports have raised concerns about the development of osteonecrosis. Though the mechanism of bisphosphonate-related osteonecrosis of the jaw […]
Relational Experiences in School-Based Mentoring: The Mediating Role of Rejection Sensitivity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
In this study, we examined associations between mentoring relationship quality, rejection sensitivity, and youth outcomes. Participants (N = 446) were part of a national, random assignment evaluation of Big Brothers Big Sisters of America school-based mentoring programs. Youth in more trusting mentoring relationships demonstrated reductions in teacher-reported behavioral evidence of rejection sensitivity. These reductions, in […]
TUG1: a pivotal oncogenic long non-coding RNA of human cancers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Abstract Long non-coding RNAs (lncRNAs) are a group greater than 200 nucleotides in length. An increasing number of studies has shown that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, invasion and chromatin remodelling. In this regard, deregulation of lncRNAs has been documented in human cancers. TUG1 is a recently identified […]
HIV
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the […]
The Journal of Law, Medicine & Ethics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
The Journal of Law, Medicine & Ethics, published by SAGE Publications, last updated on 2016-06-23, available at http://lme.sagepub.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://lme.sagepub.com/ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Patients experiences of deep brain stimulation for Parkinson’s disease: a qualitative systematic review and synthesis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objective To review and synthesise qualitative research studies that have explored patients’ experience of deep brain stimulation (DBS) in advanced Parkinson’s disease (PD). Design Systematic review and meta-synthesis of 7 original papers, using metaethnography. Setting Studies conducted in Denmark, France and Sweden. Participants 116 patients who had undergone DBS and 9 spouses of patients. Results […]
A survey of social support for exercise and its relationship to health behaviours and health status among endurance Nordic skiers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objectives Regular exercise is a key component of obesity prevention and 48% of Americans do not meet minimum guidelines for weekly exercise. Social support has been shown to help individuals start and maintain exercise programmes. We evaluated social support among endurance athletes and explored the relationship between social support for exercise, health behaviours and health […]
What are the cost savings associated with providing access to specialist care through the Champlain BASE eConsult service? A costing evaluation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objective This study estimates the costs and potential savings associated with all eConsult cases completed between 1 April 2014 and 31 March 2015. Design Costing evaluation from the societal perspective estimating the costs and potential savings associated with all eConsults completed during the study period. Setting Champlain health region in Eastern Ontario, Canada. Population Primary […]
Measuring engagement in advance care planning: a cross-sectional multicentre feasibility study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objectives To assess the feasibility, acceptability and clinical sensibility of a novel survey, the advance care planning (ACP) Engagement Survey, in various healthcare settings. Setting A target sample of 50 patients from each of primary care, hospital, cancer care and dialysis care settings. Participants A convenience sample of patients without cognitive impairment who could speak […]
«You don’t immediately stick a label on them»: a qualitative study of influences on general practitioners’ recording of anxiety disorders
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objectives Anxiety is a common condition usually managed in general practice (GP) in the UK. GP patient records can be used for epidemiological studies of anxiety as well as clinical audit and service planning. However, it is not clear how general practitioners (GPs) conceptualise, diagnose and document anxiety in these records. We sought to understand […]
Fathers role in supporting breastfeeding of preterm infants in the neonatal intensive care unit: a qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Objective To analyse the social beliefs, representations and experiences of fathers of preterm newborns (NBs) regarding breastfeeding. Design A qualitative interview study with analysis of transcripts using the Alceste software. Setting A tertiary university hospital neonatal intensive care unit (NICU) in France. Participants 20 fathers of preterm NBs hospitalised in an NICU. Results The software […]
Anesthetic management of a patient with polycythemia vera for neurosurgery
Anesthetic management of a patient with polycythemia vera for neurosurgery: AbstractPolycythemia vera (PV) is a myeloproliferative disorder characterized by excess red cell clonality. The increased number of red blood cells can lead to increased viscosity of the blood and ultimately compromise the blood supply to the end organs. Thromboembolic and hemorrhagic complications can also develop. Patients with PV presenting with neurological diseases that require surgical intervention are at an increased risk due to various factors, such as immobility, prolonged surgical time, hypothermi... περισσότερα »
Thirty-Day Hospital Revisit Rates in Patients Undergoing Septorhinoplasty
Thirty-Day Hospital Revisit Rates in Patients Undergoing Septorhinoplasty: This cohort analysis uses data from the Healthcare Cost and Utilization Project databases to determine the rate of 30-day hospital revisits following septorhinoplasty and the risk factors associated with revisits. Importance Estimates of the 30-day hospital revisit rate following septorhinoplasty and the risk factors associated with revisits are unknown in the current literature. Surgical 30-day readmission rates are important to establish, as they are increasingly used as a quality care metric and can ... περισσότερα »
Eyelid Position in Facial Nerve Palsy
Eyelid Position in Facial Nerve Palsy: This retrospective cohort study describes eyelid malposition in facial nerve palsy. Importance Understanding the prevalence and clinical features of eyelid malpositions in facial nerve palsy (FNP) may inform proper management of patients with FNP and supplement our knowledge of eyelid physiology. Objective To describe eyelid malposition in FNP. Design, Setting, and Participants In this retrospective cohort study, patients with FNP seen at the Center for Advanced Facial Plastic Surgery and Jules Stein Eye Institute between January 1,... περισσότερα »
Filler Enhancement of the Superior Periocular Area
Filler Enhancement of the Superior Periocular Area: [image: s_qpe160004f1.png] This Surgery Pearl reports that detailed knowledge of anatomy and careful placement of hyaluronic acid filler can be used to restore volume to the eyebrow, forehead, and superior sulcus to improve appearance and patient satisfaction. This Surgery Pearl reports that detailed knowledge of anatomy and careful placement of hyaluronic acid filler can be used to restore volume to the eyebrow, forehead, and superior sulcus to improve appearance and patient satisfaction. Human appearance and nonverbal comm... περισσότερα »
Transposition of the Intratemporal Facial to Hypoglossal Nerve : Reanimation of the Paralyzed Face
Reanimation of the Paralyzed Face: This case series examines the outcomes of the transposition of the infratemeporal facial nerve for end-to-side coaptation to the hypoglossal nerve for facial reanimation and reinnervation. Importance The hypoglossal nerve has long been an axonal source for reinnervation of the paralyzed face. In this study, we report our experience with transposition of the intratemporal facial nerve to the hypoglossal nerve for facial reanimation. Objectives To determine the feasibility and outcomes of the transposition of the infratemeporal facial nerve... περισσότερα »
Plastic reconstructive surgery techniques for defect coverage of extended skull base defects
Plastic reconstructive surgery techniques for defect coverage of extended skull base defects: Large skull base defects are extremely difficult to treat and have a severe impact on patients’ physical appearance and functional aspects. These extensive defect zones are mainly caused by trauma, surgical interventions or wide tumor excision. High-level microsurgical techniques are necessary in order to provide sufficient treatment. The aim of this study is to describe successful reconstructive strategies for surgical treatment. AbstractBackground Large skull base defects are extreme... περισσότερα »
A Smart-Home System to Unobtrusively and Continuously Assess Loneliness in Older Adults
A Smart-Home System to Unobtrusively and Continuously Assess Loneliness in Older Adults: Loneliness is a common condition in older adults and is associated with increased morbidity and mortality, decreased sleep quality, and increased risk of cognitive decline. Assessing loneliness in older adults is challenging due to the negative desirability biases associated with being lonely. Thus, it is necessary to develop more objective techniques to assess loneliness in older adults. In this paper, we describe a system to measure loneliness by assessing in-home behavior using wireless motio... περισσότερα »
Sensitive detection of Porphyromonas gingivalis
Sensitive detection of Porphyromonas gingivalis based on magnetic capture and upconversion fluorescent identification with multifunctional nanospheres: A specific and sensitive detection system was designed to detect *Porphyromonas gingivalis*, a major periodontal pathogen, in mixed bacterial fluids. This new detection system was based on the use of fluorescent and magnetic encoding nanospheres that were conjugated with monoclonal antibodies specific to *P. gingivalis*, thus enabling rapid detection of the target bacterium. This strategy simplifies the detection process and improve... περισσότερα »
Lipoma of the parotid gland after trauma
: a case report and review via British Journal of Oral and Maxillofacial Surgery *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Satnam Singh Rehal, Mustansir Alibhai, Esther Perera [image: Coronal magnetic resonance image showing the extent of the lipoma and ...] [image: The resected parotid lipoma enclosed within a thin fibrous capsule.]
Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells
Influence of zoledronic acid on proliferation, migration, and apoptosis of vascular endothelial cells: Bisphosphonates are commonly used to treat malignant tumours that originate in bone. In recent years, with the widespread application of these drugs in chemotherapy, reports have raised concerns about the development of osteonecrosis. Though the mechanism of bisphosphonate-related osteonecrosis of the jaw is not clear, vascular injury resulting from their use has been suggested as a possible cause. This study was designed to explore the influence of zoledronic acid, one of the mos... περισσότερα »
Detailed anatomy of the retaining ligaments of the mandible for facial rejuvenation
Detailed anatomy of the retaining ligaments of the mandible for facial rejuvenation: To present anatomical characteristics of three true ligaments of the mandible and better understanding of jowl formation. SummaryPurpose To present anatomical characteristics of three true ligaments of the mandible and better understanding of jowl formation. Materials and methods Facial dissections were performed in 10 fresh cadavers (20 hemifaces) using 2.5 magnifying surgical loupes. Mental ligament, medial mandibular ligament, and mandibular osteocutaneous ligament were identified as thick fi... περισσότερα »
Bisphosphonate-related osteonecrosis of the jaws stage II/III patients
Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients: Bisphosphonates are used in the treatment of osteoporosis and bone metastases. They inhibit osteoclast function, thereby decreasing bone resorption. A side effect of these drugs is bisphosphonate-related osteonecrosis of the jaw (BRONJ), which can be difficult to treat. The purpose of this study was to evaluate the surgical treatment protocol used in our hospital for BRONJ patients. The patients were retrospectively analyzed and followed-up at the Leiden... περισσότερα »
Orbital Adherence Syndrome following the Use of Titanium Precontoured Orbital Mesh for the Reconstruction of Posttraumatic Orbital Floor Defects
Orbital Adherence Syndrome following the Use of Titanium Precontoured Orbital Mesh for the Reconstruction of Posttraumatic Orbital Floor Defects: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1584398 Orbital blowout fractures are a common occurrence following orbital trauma. Depending on the size of the defect and the contents that have herniated or incarcerated, possible sequelae include enophthalmos, diplopia, dystopia, and entrapment. Surgical intervention aims to prevent or alleviate this through the use of a bone graft or an alloplastic implant to reconstitute t... περισσότερα »
Allergy and Immunology
4h Current Opinion in Immunology - Just Published Epitope-focused vaccine design against influenza A and B viruses Huanhuan Ren | Paul Zhou 4h Current Opinion in Immunology - Just Published Antibody-guided vaccine design: identification of protective epitopes Antonio Lanzavecchia | Alexander Frühwirth | Laurent Perez | Davide Corti 6h Viral Immunology - Table of Contents Gene Polymorphisms and Serum Levels of Pro- and Anti-Inflammatory Markers in Dengue Viral Infections Viral Immunology , Vol. 0, No. 0. 7h Annals of Allergy, Asthma & Immunology Who to Vax We live in an exciting b... περισσότερα »
Chemical Senses
14h Chemical Senses Odor-Specific Loss of Smell Sensitivity with Age as Revealed by the Specific Sensitivity Test The perception of odor mixtures plays an important role in human food intake, behavior, and emotions. Decline of smell acuity with normal aging could impact food perception and preferences at various ages. However, since the landmark Smell Survey by National Geographic, little has been elucidated on... 14h Chemical Senses Sampling the Body Odor of Primates: Cotton Swabs Sample Semivolatiles Rather Than Volatiles We assessed the suitability of a frequently used sampli... περισσότερα »
Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies
Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies: *Conditions*: Malignant Neoplasms of Digestive Organs; Malignant Neoplasms of Female Genital Organs; Malignant Neoplasms of Lip Oral Cavity and Pharynx; Malignant Neoplasms of Male Genital Organs *Interventions*: Drug: Alisertib; Drug: TAK-228 *Sponsors*: M.D. Anderson Cancer Center; Millennium Pharmaceuticals, Inc. ArmsAssigned Interventions Experimental: Alisertib + TAK-228 Dose Escalation Phase: Starting dose of Alisertib: 30 mg by mouth 2 times a day on Days 1 - 7 ea... περισσότερα »
Perioperative Geriatrics Intervention for Older Cancer Patients Undergoing Surgical Resection
Perioperative Geriatrics Intervention for Older Cancer Patients Undergoing Surgical Resection: *Conditions*: Pancreatic Cancer; Esophageal Cancer; Gastric Cancer *Interventions*: Other: Usual Care; Other: Perioperative Geriatrics Intervention *Sponsors*: Massachusetts General Hospital; National Comprehensive Cancer Network ArmsAssigned Interventions Experimental: Perioperative Geriatrics Intervention Treatment Patients randomized to the perioperative geriatrics intervention will undergo evaluation with a board-certified Massachusetts General Hospital (MGH) geriatric... περισσότερα »
Pediatric Otolaryngologists’ Views About Practice Patterns and Workforce
Pediatric Otolaryngologists’ Views About Practice Patterns and Workforce: This survey study evaluates the views of pediatric otolaryngologists toward current practice patterns of and projections for the US pediatric otolaryngology workforce. Importance This study represents up-to-date information on the current status of and future projections for the pediatric otolaryngology workforce. Objective To provide an update on the practice patterns of and projections for the US pediatric otolaryngology workforce. Design, Setting, and Participants An online survey was sent to al... περισσότερα »
Association of TMTC2 and Sensorineural Hearing Loss
Association of TMTC2 and Sensorineural Hearing Loss: This prospective genotype and phenotype study identifies a candidate gene that causes bilateral, symmetric, progressive sensorineural hearing loss in a large multigeneration family of Northern European descent. Importance Sensorineural hearing loss (SNHL) is commonly caused by conditions that affect cochlear structures or the auditory nerve, and the genes identified as causing SNHL to date only explain a fraction of the overall genetic risk for this debilitating disorder. It is likely that other genes and mutations also caus... περισσότερα »
Nerve Monitoring and Postoperative Facial Paralysis in Parotidectomy
Nerve Monitoring and Postoperative Facial Paralysis in Parotidectomy: This review assesses the utility of intraoperative facial nerve monitoring in 2 groups of patients undergoing partial and total parotidectomies. Importance Electrophysiologic facial nerve monitoring is becoming an established intraoperative aid to assist the surgeon in facial nerve trunk or branch location and dissection. Limited studies have addressed the postoperative outcomes of parotid surgery with and without monitoring. Objective To examine the influence of intraoperative facial nerve monitoring on ... περισσότερα »
A Tracheal Mass
A Tracheal Mass: A woman had a cervical tracheal mass on magnetic resonance imaging for cervical spine pain; flexible fiber-optic nasolaryngoscopy demonstrated a smooth hypervascular mass arising from the posterior membranous trachea. What is your diagnosis? [image: First page PDF preview]
Round Window vs Cochleostomy and Cochlear Implant Electrode Position
Round Window vs Cochleostomy and Cochlear Implant Electrode Position: This study of 17 patients with cochlear implants uses flat-panel computed tomography to compare intracochlear electrode position in those who had undergone round window insertion vs the cochleostomy approach. Importance The round window insertion (RWI) and cochleostomy approaches are the 2 most common surgical techniques used in cochlear implantation (CI). However, there is no consensus on which approach is ideal for electrode array insertion, in part because visualization of intracochlear electrode position... περισσότερα »
Survival and Lower Gastrostomy Prevalence in Oropharyngeal Cancer
Survival and Lower Gastrostomy Prevalence in Oropharyngeal Cancer: This matched-cohort study compares survival and gastrostomy prevalence between patients with oropharyngeal squamous cell carcinoma treated with transoral robotic surgery–based therapy and those treated with nonsurgical therapy. Importance Treatment of oropharyngeal squamous cell carcinoma (OPSCC) presents unique challenges and can be associated with significant morbidity. Transoral robotic surgery (TORS) has emerged as a treatment modality for OPSCC, but data comparing outcomes between patients treated with TOR... περισσότερα »
The timing of videofluoroscopic swallow studies (VFSSs) in determining resolving aspiration after laryngeal cleft repair
Reducing Postoperative VFSSs in Type 1 Laryngeal Cleft Repair: The authors modify a previously published best-practice algorithm based on a literature review and clinical experience to maintain the quality of care provided after successful type 1 laryngeal cleft repair, while reducing the total number of postoperative videofluoroscopic swallow studies. Importance There is no consensus as to the timing of videofluoroscopic swallow studies (VFSSs) in determining resolving aspiration after laryngeal cleft repair. There is a growing literature on the effect of radiation exposure i... περισσότερα »
Evaluation of the benefit and use of multidisciplinary teams in the treatment of head and neck cancer
Evaluation of the benefit and use of multidisciplinary teams in the treatment of head and neck cancer: Given the complexities of multimodality treatment for patients with cancer, no one medical professional can possess the necessary background to make optimal treatment decisions independently or avoid inevitable unconscious bias toward their own area of expertise. In most major cancer types, multidisciplinary teams (MDTs) were implemented previously, and, in recent years, the MDT approach has been extended to head and neck cancer. Head and neck cancers involve several anatomically d... περισσότερα »
EVALUATION OF FEED RESOURCE AVAILABILITY FOR RUMINANT PRODUCTION IN NORTHERN GHANA
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
2016-06-23T22-50-33Z *Source:* International Journal of Livestock Research Solomon Pigangsoa Konlan, Augustine Abioye Ayantunde, Weseh Addah, Kwabla Herbert Dei. Abstract Livestock production system in northern Ghana is constrained by many factors of which feed shortage in quantity and quality constitute a major challenge. An evaluation of ruminant feed availability to identify critical seasonal shortages and other related constraints affecting ruminant production among smallholder farmers was done in northern Ghana (Northern, Upper East and Upper West Regions). The data was collect... περισσότερα »
The slow component of pulmonary O2 uptake accompanies peripheral muscle fatigue during high intensity exercise
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
During constant-power output (PO) exercise above lactate threshold (LT), pulmonary O2 uptake (VO2p) features a developing slow component (VO2pSC). This progressive increase in O2 cost of exercise is suggested to be related to the effects of muscle fatigue development. We hypothesized that peripheral muscle fatigue, as assessed by contractile impairment, would be associated with the VO2pSC. Eleven healthy men were recruited to perform four constant-PO tests at an intensity corresponding to ~60 (very heavy, VH) where is 60% of the difference between LT and peak VO2p. The VH exercise... περισσότερα »
RESISTANCE OR AEROBIC TRAINING DECREASES BLOOD PRESSURE AND IMPROVES CARDIOVASCULAR AUTONOMIC CONTROL AND OXIDATIVE STRESS IN HYPERTENSIVE MENOPAUSAL RATS
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
We investigated whether resistance training (RT) vs. aerobic training (AT) differentially impacts on arterial pressure and related mechanisms in ovariectomized spontaneously hypertensive rats (SHR). Female SHR were ovariectomized and assigned to one of the groups: sedentary, AT, or RT; sham sedentary SHR were used as control group. AT was performed on a treadmill, while RT was performed on a vertical ladder. Both exercise protocols were performed for 8 weeks, 5 days/week. Arterial pressure, baroreflex sensitivity, autonomic modulation, and cardiac oxidative stress parameters (lipi... περισσότερα »
New Opportunities for Authors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
N/A from Physiology via xlomafota13 on Inoreader http://ift.tt/2913FsQ via IFTTT
Embedded Instruction Improves Vocabulary Learning During Automated Storybook Reading Among High-Risk Preschoolers
Purpose We investigated a small-group intervention designed to teach vocabulary and comprehension skills to preschoolers who were at risk for language and reading disabilities. These language skills are important and reliable predictors of later academic achievement. Method Preschoolers heard prerecorded stories 3 times per week over the course of a school year. A cluster randomized design was used to evaluate the effects of hearing storybooks with and without embedded vocabulary and comprehension lessons. A total of 32 classrooms were randomly assigned to experimental and compariso... περισσότερα »
On Older Listeners' Ability to Perceive Dynamic Pitch
Purpose Natural speech comes with variation in pitch, which serves as an important cue for speech recognition. The present study investigated older listeners' dynamic pitch perception with a focus on interindividual variability. In particular, we asked whether some of the older listeners' inability to perceive dynamic pitch stems from the higher susceptibility to the interference from formant changes. Method A total of 22 older listeners and 21 younger controls with at least near-typical hearing were tested on dynamic pitch identification and discrimination tasks using synthetic mon... περισσότερα »
TUG1: a pivotal oncogenic long non-coding RNA of human cancers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Abstract Long non-coding RNAs (lncRNAs) are a group greater than 200 nucleotides in length. An increasing number of studies has shown that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, invasion and chromatin remodelling. In this regard, deregulation of lncRNAs has been documented in human cancers. TUG1 is a recently identified […]
HIV
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the […]
The Journal of Law, Medicine & Ethics
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
The Journal of Law, Medicine & Ethics, published by SAGE Publications, last updated on 2016-06-23, available at http://lme.sagepub.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://lme.sagepub.com/ via IFTTT
Patients experiences of deep brain stimulation for Parkinson’s disease: a qualitative systematic review and synthesis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objective To review and synthesise qualitative research studies that have explored patients’ experience of deep brain stimulation (DBS) in advanced Parkinson’s disease (PD). Design Systematic review and meta-synthesis of 7 original papers, using metaethnography. Setting Studies conducted in Denmark, France and Sweden. Participants 116 patients who had undergone DBS and 9 spouses of patients. Results […]
A survey of social support for exercise and its relationship to health behaviours and health status among endurance Nordic skiers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objectives Regular exercise is a key component of obesity prevention and 48% of Americans do not meet minimum guidelines for weekly exercise. Social support has been shown to help individuals start and maintain exercise programmes. We evaluated social support among endurance athletes and explored the relationship between social support for exercise, health behaviours and health […]
What are the cost savings associated with providing access to specialist care through the Champlain BASE eConsult service? A costing evaluation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objective This study estimates the costs and potential savings associated with all eConsult cases completed between 1 April 2014 and 31 March 2015. Design Costing evaluation from the societal perspective estimating the costs and potential savings associated with all eConsults completed during the study period. Setting Champlain health region in Eastern Ontario, Canada. Population Primary […]
Measuring engagement in advance care planning: a cross-sectional multicentre feasibility study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objectives To assess the feasibility, acceptability and clinical sensibility of a novel survey, the advance care planning (ACP) Engagement Survey, in various healthcare settings. Setting A target sample of 50 patients from each of primary care, hospital, cancer care and dialysis care settings. Participants A convenience sample of patients without cognitive impairment who could speak […]
«You don’t immediately stick a label on them»: a qualitative study of influences on general practitioners’ recording of anxiety disorders
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objectives Anxiety is a common condition usually managed in general practice (GP) in the UK. GP patient records can be used for epidemiological studies of anxiety as well as clinical audit and service planning. However, it is not clear how general practitioners (GPs) conceptualise, diagnose and document anxiety in these records. We sought to understand […]
Fathers role in supporting breastfeeding of preterm infants in the neonatal intensive care unit: a qualitative study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objective To analyse the social beliefs, representations and experiences of fathers of preterm newborns (NBs) regarding breastfeeding. Design A qualitative interview study with analysis of transcripts using the Alceste software. Setting A tertiary university hospital neonatal intensive care unit (NICU) in France. Participants 20 fathers of preterm NBs hospitalised in an NICU. Results The software […]
Smoking and serum vitamin D in older Chinese people: cross-sectional analysis based on the Guangzhou Biobank Cohort Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Objective Studies on serum vitamin D in smokers showed conflicting results. We examined the association of smoking status with serum vitamin D in older Chinese men, taking advantage of a community-based sample with natural exposure to vitamin D. Design Cross-sectional study based on the Guangzhou Biobank Cohort Study (GBCS). Setting Community-based sample from the Guangzhou […]
The Effect of Auditory Information on Patterns of Intrusions and Reductions
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
The Effect of Auditory Information on Patterns of Intrusions and Reductions: Purpose The study investigates whether auditory information affects the nature of intrusion and reduction errors in reiterated speech. These errors are hypothesized to arise as a consequence of autonomous mechanisms to stabilize movement coordination. The specific question addressed is whether this process is affected […]
Story Goodness in Adolescents With Autism Spectrum Disorder (ASD) and in Optimal Outcomes From ASD
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Story Goodness in Adolescents With Autism Spectrum Disorder (ASD) and in Optimal Outcomes From ASD: Purpose This study examined narrative quality of adolescents with autism spectrum disorder (ASD) using a well-studied “story goodness” coding system. Method Narrative samples were analyzed for distinct aspects of story goodness and rated by naïve readers on dimensions of story […]
Prevalence and Nature of Hearing Loss in 22q11.2 Deletion Syndrome
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Prevalence and Nature of Hearing Loss in 22q11.2 Deletion Syndrome: Purpose The purpose of this study was to clarify the prevalence, type, severity, and age-dependency of hearing loss in 22q11.2 deletion syndrome. Method Extensive audiological measurements were conducted in 40 persons with proven 22q11.2 deletion (aged 6–36 years). Besides air and bone conduction thresholds in […]
Simultaneous determination of environmental estrogens: Diethylstilbestrol and estradiol using Cu-BTC frameworks-sensitized electrode
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Liudi Ji, Yanying Wang, Kangbing Wu, Weikang Zhang It is quite important to monitor environmental estrogens in a rapid, sensitive, simple and cost-effective manner due to their wide existence and high toxicity. Using 1,3,5-Benzenetricarboxylic acid (H3BTC) as the ligand and copper ions as the center, Cu-BTC frameworks with surface area of 654.6m 2/g were prepared, and then used to construct a novel electrochemical sensing platform for diethylstilbestrol (DES) and estradiol (E2). On the surface of Cu-BTC framewor... περισσότερα »
Application of dried blood spot cards to determine olive oil phenols (hydroxytyrosol metabolites) in human blood
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): María Carmen López de las Hazas, Maria José Motilva, Carme Piñol, Alba Macià In this study, a fast and simple blood sampling and sample pre-treatment method based on the use of the dried blood spot (DBS) cards and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) for the quantification of olive oil phenolic metabolites in human blood was developed and validated. After validation, the method was applied to determine hydroxytyrosol metabolites in human blood samples after t... περισσότερα »
Copolymeric hexyl acrylate-methacrylic acid microspheres – surface vs. bulk reactive carboxyl groups. Coulometric and colorimetric determination and analytical applications for heterogeneous microtitration
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Emilia Stelmach, Krzysztof Maksymiuk, Agata Michalska Copolymeric acrylate microspheres were prepared from hexyl acrylate using different amounts of methacrylic acid, resulting in a series of microspheres of gradually changing properties. The distribution of carboxyl groups – between surface and bulk of microspheres was evaluated. Bulk reactive carboxyl groups were determined using reverse coulometric titration with H+ ions, following hydroxide ions have been generated and allowed to react with microspheres in ... περισσότερα »
Nuclear forensic analysis of a non-traditional actinide sample
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Jamie L. Doyle, Kevin Kuhn, Benjamin Byerly, Lisa Colletti, James Fulwyler, Katherine Garduno, Russel Keller, Elmer Lujan, Alexander Martinez, Steve Myers, Donivan Porterfield, Khalil Spencer, Floyd Stanley, Lisa Townsend, Mariam Thomas, Laurie Walker, Ning Xu, Lav Tandon Nuclear forensic publications, performance tests, and research and development efforts typically target the bulk global inventory of intentionally safeguarded materials, such as plutonium (Pu) and uranium (U). Other materials, such as neptuniu... περισσότερα »
Synthesis of single-crystal α-MnO2 nanotubes-loaded Ag@C core–shell matrix and their application for electrochemical sensing of nonenzymatic hydrogen peroxide
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Sai Zhang, Jianbin Zheng A nonenzymatic hydrogen peroxide sensor was fabricated by combing the crystal α-MnO2 nanotubes and Ag@C core–shell matrix with their own superior characteristics. The morphology, size and electrochemical of the sensing interface materials and the relationship between the electrical catalytic properties and sensor response performance were also studied, established a new method for the detection of hydrogen peroxide (H2O2). The structure and morphology of hollow tubular-like MnO2 and MnO... περισσότερα »
Inside front cover
Publication date: 1 September 2016 *Source:*Talanta, Volume 158 from #Medicine via ola Kala on Inoreader http://ift.tt/28SR9ig via IFTTT
Development and validation of a RP-UHPLC-ESI-MS/MS method for the chiral separation and determination of flavanone, naringenin and hesperetin enantiomers
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Irena Baranowska, Judyta Hejniak, Sylwia Magiera A quick and sensitive RP-UHPLC-ESI-MS/MS method for the separation of flavanone, naringenin and hesperetin enantiomers was developed. The separation of analytes was performed using a Chiralpak AD-3R column, and methanol was used as the mobile phase. Detection was carried out using a triple quadrupole tandem mass spectrometer with an electrospray ionisation source. Positive ionisation and multiple reaction monitoring (MRM) were used. The developed method showed sa... περισσότερα »
Highly sensitive nonenzymatic glucose sensor based on nickel nanoparticle–attapulgite-reduced graphene oxide-modified glassy carbon electrode
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Zongxu Shen, Wenyu Gao, Pei Li, Xiaofang Wang, Qing Zheng, Hao Wu, Yuehui Ma, Weijun Guan, Songmei Wu, Yu Yu, Kejian Ding In this article, a fast and sensitive nonenzymatic glucose sensor is reported utilizing a glassy carbon electrode modified by synthesizing nanocomposites of nickel nanoparticle–attapulgite-reduced graphene oxide (Ni NPs/ATP/RGO). A facile one-step electrochemical co-deposition approach is adopted to synthesize Ni NPs-ATP-RGO nanocomposites via electrochemical reduction of mixed precursor sol... περισσότερα »
A rapid and ultrasensitive SERRS assay for histidine and tyrosine based on azo coupling
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Huimin Sui, Yue Wang, Zhi Yu, Qian Cong, Xiao Xia Han, Bing Zhao A simple and highly sensitive surface-enhanced resonance Raman scattering (SERRS)-based approach coupled with azo coupling reaction has been put forward for quantitative analysis of histidine and tyrosine. The SERRS-based assay is simple and rapid by mixing the azo reaction products with silver nanoparticles (AgNPs) for measurements within 2min. The limits of detection (LODs) of the method are as low as 4.33×10−11 and 8.80×10−11M for histidine and... περισσότερα »
Ionic liquid coated carbon nanospheres as a new adsorbent for fast solid phase extraction of trace copper and lead from sea water, wastewater, street dust and spice samples
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Şerife Tokalıoğlu, Emre Yavuz, Halil Şahan, Süleyman Gökhan Çolak, Kasım Ocakoğlu, Mehmet Kaçer, Şaban Patat In this study a new adsorbent, ionic liquid (1,8-naphthalene monoimide bearing imidazolium salt) coated carbon nanospheres, was synthesized for the first time and it was used for the solid phase extraction of copper and lead from various samples prior to determination by flame atomic absorption spectrometry. The ionic liquid, carbon nanospheres and ionic liquid coated carbon nanospheres were characterize... περισσότερα »
Pre-analytical and analytical validations and clinical applications of a miniaturized, simple and cost-effective solid phase extraction combined with LC-MS/MS for the simultaneous determination of catecholamines and metanephrines in spot urine samples
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Xiaoguang (Sunny) Li, Shu Li, Gottfried Kellermann It remains a challenge to simultaneously quantify catecholamines and metanephrines in a simple, sensitive and cost-effective manner due to pre-analytical and analytical constraints. Herein, we describe such a method consisting of a miniaturized sample preparation and selective LC-MS/MS detection by the use of second morning spot urine samples. Ten microliters of second morning urine sample were subjected to solid phase extraction on an Oasis HLB microplate upon... περισσότερα »
Bright and photostable fluorescent probe with aggregation-induced emission characteristics for specific lysosome imaging and tracking
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Jiang Ouyang, Qiguang Zang, Wansong Chen, Liqiang Wang, Shuo Li, Ren-Yu Liu, Yuanyuan Deng, Zhao-Qian Liu, Juan Li, Liu Deng, You-Nian Liu We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton. Due to both the AIE and antenna effects, TPE-MPL possesses superior photostability, appreciable tolerance to microenvironment change and high lysosome targeting ability. ... περισσότερα »
Editorial Board
Publication date: 1 September 2016 *Source:*Talanta, Volume 158 from #Medicine via ola Kala on Inoreader http://ift.tt/2912rO2 via IFTTT
Determination of oleuropein using multiwalled carbon nanotube modified glassy carbon electrode by adsorptive stripping square wave voltammetry
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Mustafa Cittan, Süleyman Koçak, Ali Çelik, Kenan Dost A multi-walled carbon nanotube modified glassy carbon electrode was used to prepare an electrochemical sensing platform for the determination of oleuropein. Results showed that, the accumulation of oleuropein on the prepared electrode takes place with the adsorption process. Electrochemical behavior of oleuropein was studied by using cyclic voltammetry. Compared to the bare GCE, the oxidation peak current of oleuropein increased about 340 times at MWCNT/GCE.... περισσότερα »
Microwave-assisted enzymatic hydrolysis followed by extraction with restricted access nanocomposites for rapid analysis of glucocorticoids residues in liver tissue
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Jianan Feng, Xiaodan Liu, Yan Li, Gengli Duan We developed a novel, simple and fast method for the determination of glucocorticoids residues in liver tissue by combining microwave-assisted enzymatic hydrolysis and restricted access matrix dispersive solid phase extraction (RAM-dSPE) followed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Firstly, microwave-assisted enzymatic hydrolysis was introduced in order to obtain a maximum amount of unconjugated parent drug in a short time (8s), ... περισσότερα »
Simultaneous analysis of multiple classes of antimicrobials in environmental water samples using SPE coupled with UHPLC-ESI-MS/MS and isotope dilution
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Ngoc Han Tran, Hongjie Chen, Thanh Van Do, Martin Reinhard, Huu Hao Ngo, Yiliang He, Karina Yew-Hoong Gin A robust and sensitive analytical method was developed for the simultaneous analysis of 21 target antimicrobials in different environmental water samples. Both single SPE and tandem SPE cartridge systems were investigated to simultaneously extract multiple classes of antimicrobials. Experimental results showed that good extraction efficiencies (84.5–105.6%) were observed for the vast majority of the target ... περισσότερα »
Speciation of inorganic selenium in environmental samples after suspended dispersive solid phase microextraction combined with inductively coupled plasma spectrometric determination
Publication date: 1 October 2016 *Source:*Talanta, Volume 159 Author(s): Luthando Nyaba, Joseph M. Matong, K. Mogolodi Dimpe, Philiswa N. Nomngongo A rapid and effective suspended dispersive solid phase microextraction (SDSPME) was developed for the speciation of inorganic selenium using alumina nanoparticles functionalized with Aliquat-336. The target analytes were preconcentrated and determined by inductively coupled plasma optical emission spectrometry. Alumina nanoparticles were characterized using XRD, BET, SEM and EDX while the functionalized nano-Al2O3 was characterized by F... περισσότερα »
Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The development of novel cancer treatments is a challenging task, partly because results from model systems often fail to predict drug efficacy in humans, and also tumors are often inaccessible for biochemical analysis, preventing effective monitoring of drug activity in vivo. Utilizing a model system, we evaluated the use of drug-induced DNA damage in […]
NEDD4L Catalyzes Ubiquitination of PIK3CA and Regulates PI3K-AKT Signaling Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Oncogenic PIK3CA (p110α), the catalytic subunit of class IA PI3K, plays a major role in PI3K related cancer progression. The mechanisms underlying the dynamic regulation of PIK3CA protein levels remain unknown. Here we demonstrated that PIK3CA is regulated by polyubiquitination. We identified NEDD4L as the E3 ligase that catalyzes PIK3CA polyubiquitination, leading to its proteasome-dependent […]
Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway Protein Synthesis and Degradation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. N-terminal sequences of AANAT enzymes vary among vertebrates. Mechanisms that regulate the levels of AANAT are incompletely understood. Previous findings were consistent with the possibility that AANAT may […]
The slow component of pulmonary O2 uptake accompanies peripheral muscle fatigue during high intensity exercise
During constant-power output (PO) exercise above lactate threshold (LT), pulmonary O2 uptake (VO2p) features a developing slow component (VO2pSC). This progressive increase in O2 cost of exercise is suggested to be related to the effects of muscle fatigue development. We hypothesized that peripheral muscle fatigue, as assessed by contractile impairment, would be associated with the VO2pSC. Eleven healthy men were recruited to perform four constant-PO tests at an intensity corresponding to ~60 (very heavy, VH) where is 60% of the difference between LT and peak VO2p. The VH exercise... περισσότερα »
RESISTANCE OR AEROBIC TRAINING DECREASES BLOOD PRESSURE AND IMPROVES CARDIOVASCULAR AUTONOMIC CONTROL AND OXIDATIVE STRESS IN HYPERTENSIVE MENOPAUSAL RATS
We investigated whether resistance training (RT) vs. aerobic training (AT) differentially impacts on arterial pressure and related mechanisms in ovariectomized spontaneously hypertensive rats (SHR). Female SHR were ovariectomized and assigned to one of the groups: sedentary, AT, or RT; sham sedentary SHR were used as control group. AT was performed on a treadmill, while RT was performed on a vertical ladder. Both exercise protocols were performed for 8 weeks, 5 days/week. Arterial pressure, baroreflex sensitivity, autonomic modulation, and cardiac oxidative stress parameters (lipi... περισσότερα »
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N/A from Physiology via xlomafota13 on Inoreader http://ift.tt/2913FsQ
Anti-apoptotic Effect of Exercise Training on Ovariectomized Rat Hearts
Background. The purpose of this study was to evaluate the effects of exercise training on cardiac Fas receptor-dependent and mitochondria-dependent apoptotic pathways in ovariectomized rats. Methods. Histopathological analysis, TUNEL assay, and Western blotting were performed on the excised hearts from three groups of Sprague-Dawley rats, which were divided into a sham-operated group (Sham), a bilaterally ovariectomized group (OVX), and a bilaterally ovariectomized rats underwent treadmill running exercise for 60 min / day, 5 sessions / week, for 10 weeks (OVX-EX). Results. The ab... περισσότερα »
Lifelong strength training mitigates the age-related decline in efferent drive
Recently we documented age-related attenuation of efferent drive to contracting skeletal muscle. It remains elusive if this indication of reduced muscle strength is present with lifelong strength training. For this purpose, we examined evoked potentials in the calf muscles of 11 (71±4years) strength trained master athletes (MA) contrasted to 10 (71±4years) sedentary (SO) and 11 (73±6years) recreationally active (AO) old subjects, as well as 9 (22±2years) young controls. As expected, MA had higher leg press maximal strength (MA: 185±32kg; AO: 128±15kg; SO: 106±11kg; young: 147±22kg... περισσότερα »
Neural signature of reward-modulated unconscious inhibitory control
[image: alertIcon.gif] Publication date: Available online 23 June 2016 *Source:*International Journal of Psychophysiology Author(s): Liuting Diao, Senqing Qi, Mengsi Xu, Zhiai Li, Cody Ding, Antao Chen, Yan Zheng, Dong Yang Consciously initiated cognitive control is generally determined by motivational incentives (e.g., monetary reward). Recent studies have revealed that human cognitive control processes can nevertheless operate without awareness. However, whether monetary reward can impinge on unconscious cognitive control remains unclear. To clarify this issue, a task consisting o... περισσότερα »
Anti-apoptotic Effect of Exercise Training on Ovariectomized Rat Hearts
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Background. The purpose of this study was to evaluate the effects of exercise training on cardiac Fas receptor-dependent and mitochondria-dependent apoptotic pathways in ovariectomized rats. Methods. Histopathological analysis, TUNEL assay, and Western blotting were performed on the excised hearts from three groups of Sprague-Dawley rats, which were divided into a sham-operated group (Sham), a bilaterally ovariectomized group (OVX), and a bilaterally ovariectomized rats underwent treadmill running exercise for 60 min / day, 5 sessions / week, for 10 weeks (OVX-EX). Results. The ab... περισσότερα »
Lifelong strength training mitigates the age-related decline in efferent drive
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Recently we documented age-related attenuation of efferent drive to contracting skeletal muscle. It remains elusive if this indication of reduced muscle strength is present with lifelong strength training. For this purpose, we examined evoked potentials in the calf muscles of 11 (71±4years) strength trained master athletes (MA) contrasted to 10 (71±4years) sedentary (SO) and 11 (73±6years) recreationally active (AO) old subjects, as well as 9 (22±2years) young controls. As expected, MA had higher leg press maximal strength (MA: 185±32kg; AO: 128±15kg; SO: 106±11kg; young: 147±22kg... περισσότερα »
Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bisphosphonates are used in the treatment of osteoporosis and bone metastases. They inhibit osteoclast function, thereby decreasing bone resorption. A side effect of these drugs is bisphosphonate-related osteonecrosis of the jaw (BRONJ), which can be difficult to treat. The purpose of this study was to evaluate the surgical treatment protocol used in our hospital for […]
Detailed anatomy of the retaining ligaments of the mandible for facial rejuvenation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
To present anatomical characteristics of three true ligaments of the mandible and better understanding of jowl formation. (Source: Journal of Cranio-Maxillofacial Surgery) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28S2ISX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Primary stability and osseointegration of dental implants in polylactide modified bone – A pilot study in Goetti ngen minipigs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(l-lactide-co-d, l-lactide); (PLDLA)] modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split-mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into […]
The other side of progestins: effects in the brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Progestins are a broad class of progestational agents widely differing in their chemical structures and pharmacological properties. Despite emerging data suggest that progestins, besides their action as endometrial protection, can also have multiple non-reproductive functions, much remains to be discovered regarding the actions exerted by these molecules in the nervous system. Here, we report the […]
Factors associated with undiagnosed and overdiagnosed COPD
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Worldwide, studies have shown that about 60–86% of people with chronic obstructive pulmonary disease (COPD) have not been diagnosed, which represents a missed opportunity to decrease disease burden through optimal management, including smoking cessation support and prescription medications [1–3]. Overdiagnosed COPD is also common, with prevalence estimates ranging from 4% to 64% in the general […]
A 1-day visit in a severe asthma centre: effect on asthma control, quality of life and healthcare use
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Patients with uncontrolled asthma report ongoing symptoms, poor quality-of-life and extensive healthcare use (HCU) and might benefit from management by a specialised severe asthma team. It is unknown whether a one-time evaluation by asthma experts, without long-term supervision by a specialised team, provides favourable outcomes. We evaluated asthma control (Asthma Control Questionnaire; ACQ), quality-of-life (Asthma-related […]
Health-related quality of life in elderly patients with advanced non-small cell lung cancer comparing carboplatin and weekly paclitaxel doublet chemotherapy with monotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In the Intergroupe Francophone de Cancérologie Thoracique 0501 trial the carboplatin-paclitaxel chemotherapy increased toxicity (most frequent, decreased neutrophil count, asthenia). We longitudinally compared health-related quality of life (HRQoL) of the two treatment arms. In total, 451 patients aged 70–89 years with advanced non-small cell lung cancer (NSCLC) were randomly assigned to receive carboplatin plus paclitaxel […]
Compassionate use of new drugs in children and adolescents with multidrug-resistant and extensively drug-resistant tuberculosis: early experiences and challenges
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The World Health Organization (WHO) estimated that 480 000 new multidrug-resistant (MDR) tuberculosis (TB) cases occurred globally in 2014, with 190 000 deaths. Limited data are available on the burden of MDR-TB in children. A recent systematic review estimated that 32 000 children acquire MDR-TB annually; of these, very few are correctly diagnosed and provided […]
Is bedaquiline as effective as fluoroquinolones in the treatment of multidrug-resistant tuberculosis?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bedaquiline (Bdq) is approved for the treatment of multidrug-resistant (MDR) tuberculosis (TB). In a phase IIb trial, Bdq allowed a significant reduction in time to culture conversion and improved outcome in MDR-TB patients [1, 2]. Preliminary reports of Bdq compassionate use have shown promising results [3–5]. However, in an early bactericidal activity (EBA) study, the […]
What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) have been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains poorly defined and lacking firm evidence. To date, there is no universally accepted definition of ACOS, which has made it difficult to understand its epidemiology or pathophysiology. Despite many uncertainties, there […]
Prevalence and Nature of Hearing Loss in 22q11.2 Deletion Syndrome
Purpose The purpose of this study was to clarify the prevalence, type, severity, and age-dependency of hearing loss in 22q11.2 deletion syndrome. Method Extensive audiological measurements were conducted in 40 persons with proven 22q11.2 deletion (aged 6–36 years). Besides air and bone conduction thresholds in the frequency range between 0.125 and 8.000 kHz, high-frequency thresholds up to 16.000 kHz were determined and tympanometry, acoustic reflex (AR) measurement, and distortion product otoacoustic emission (DPOAE) testing were performed. Results Hearing loss was identified in 59... περισσότερα »
Story Goodness in Adolescents With Autism Spectrum Disorder (ASD) and in Optimal Outcomes From ASD
Purpose This study examined narrative quality of adolescents with autism spectrum disorder (ASD) using a well-studied “story goodness” coding system. Method Narrative samples were analyzed for distinct aspects of story goodness and rated by naïve readers on dimensions of story goodness, accuracy, cohesiveness, and oddness. Adolescents with high-functioning ASD were compared with adolescents with typical development (TD; n = 15 per group). A second study compared narratives from adolescents across three groups: ASD, TD, and youths with “optimal outcomes,” who were diagnosed with ASD ... περισσότερα »
The Effect of Auditory Information on Patterns of Intrusions and Reductions
Purpose The study investigates whether auditory information affects the nature of intrusion and reduction errors in reiterated speech. These errors are hypothesized to arise as a consequence of autonomous mechanisms to stabilize movement coordination. The specific question addressed is whether this process is affected by auditory information so that it will influence the occurrence of intrusions and reductions. Methods Fifteen speakers produced word pairs with alternating onset consonants and identical rhymes repetitively at a normal and fast speaking rate, in masked and unmasked sp... περισσότερα »
Return to Work and Social Communication Ability Following Severe Traumatic Brain Injury
Purpose Return to competitive employment presents a major challenge to adults who survive traumatic brain injury (TBI). This study was undertaken to better understand factors that shape employment outcome by comparing the communication profiles and self-awareness of communication deficits of adults who return to and maintain employment with those who do not. Method Forty-six dyads (46 adults with TBI, 46 relatives) were recruited into 2 groups based on the current employment status (employed or unemployed) of participants with TBI. Groups did not differ in regard to sex, age, educat... περισσότερα »
Treating Speech Comprehensibility in Students With Down Syndrome
Purpose This study examined whether a particular type of therapy (Broad Target Speech Recasts, BTSR) was superior to a contrast treatment in facilitating speech comprehensibility in conversations of students with Down syndrome who began treatment with initially high verbal imitation. Method We randomly assigned 51 5- to 12-year-old students to either BTSR or a contrast treatment. Therapy occurred in hour-long 1-to-1 sessions in students' schools twice per week for 6 months. Results For students who entered treatment just above the sample average in verbal-imitation skill, BTSR was s... περισσότερα »
Repair or Violation Detection? Pre-Attentive Processing Strategies of Phonotactic Illegality Demonstrated on the Constraint of g-Deletion in German
Purpose Effects of categorical phonotactic knowledge on pre-attentive speech processing were investigated by presenting illegal speech input that violated a phonotactic constraint in German called “g-deletion.” The present study aimed to extend previous findings of automatic processing of phonotactic violations and to investigate the role of stimulus context in triggering either an automatic phonotactic repair or a detection of the violation. Method The mismatch negativity event-related potential component was obtained in 2 identical cross-sectional experiments with speaker variatio... περισσότερα »
Measuring Speech Comprehensibility in Students with Down Syndrome
Purpose There is an ongoing need to develop assessments of spontaneous speech that focus on whether the child's utterances are comprehensible to listeners. This study sought to identify the attributes of a stable ratings-based measure of speech comprehensibility, which enabled examining the criterion-related validity of an orthography-based measure of the comprehensibility of conversational speech in students with Down syndrome. Method Participants were 10 elementary school students with Down syndrome and 4 unfamiliar adult raters. Averaged across-observer Likert ratings of speech c... περισσότερα »
Does Working Memory Enhance or Interfere With Speech Fluency in Adults Who Do and Do Not Stutter? Evidence From a Dual-Task Paradigm
Purpose The present study examined whether engaging working memory in a secondary task benefits speech fluency. Effects of dual-task conditions on speech fluency, rate, and errors were examined with respect to predictions derived from three related theoretical accounts of disfluencies. Method Nineteen adults who stutter and twenty adults who do not stutter participated in the study. All participants completed 2 baseline tasks: a continuous-speaking task and a working-memory (WM) task involving manipulations of domain, load, and interstimulus interval. In the dual-task portion of the... περισσότερα »
Analysis of 3-D Tongue Motion From Tagged and Cine Magnetic Resonance Images
Purpose Measuring tongue deformation and internal muscle motion during speech has been a challenging task because the tongue deforms in 3 dimensions, contains interdigitated muscles, and is largely hidden within the vocal tract. In this article, a new method is proposed to analyze tagged and cine magnetic resonance images of the tongue during speech in order to estimate 3-dimensional tissue displacement and deformation over time. Method The method involves computing 2-dimensional motion components using a standard tag-processing method called harmonic phase, constructing superresolu... περισσότερα »
Narratives in Two Languages: Storytelling of Bilingual Cantonese–English Preschoolers
Purpose The aim of this study was to compare narratives generated by 4-year-old and 5-year-old children who were bilingual in English and Cantonese. Method The sample included 47 children (23 who were 4 years old and 24 who were 5 years old) living in Toronto, Ontario, Canada, who spoke both Cantonese and English. The participants spoke and heard predominantly Cantonese in the home. Participants generated a story in English and Cantonese by using a wordless picture book; language order was counterbalanced. Data were transcribed and coded for story grammar, morphosyntactic quality, me... περισσότερα »
On Peer Review
Purpose This letter briefly reviews ideas about the purpose and benefits of peer review and reaches some idealistic conclusions about the process. Method The author uses both literature review and meditation born of long experience. Results From a cynical perspective, peer review constitutes an adversarial process featuring domination of the weak by the strong and exploitation of authors and reviewers by editors and publishers, resulting in suppression of new ideas, delayed publication of important research, and bad feelings ranging from confusion to fury. More optimistically, peer ... περισσότερα »
The Use of Voice Cues for Speaker Gender Recognition in Cochlear Implant Recipients
Purpose The focus of this study was to examine the influence of fundamental frequency (F0) and vocal tract length (VTL) modifications on speaker gender recognition in cochlear implant (CI) recipients for different stimulus types. Method Single words and sentences were manipulated using isolated or combined F0 and VTL cues. Using an 11-point rating scale, CI recipients and listeners with normal hearing rated the maleness/femaleness of the corresponding voice. Results Speaker gender ratings for combined F0 and VTL modifications were similar across all stimulus types in both CI recipi... περισσότερα »
The Use of Voice Cues for Speaker Gender Recognition in Cochlear Implant Recipients
Purpose The focus of this study was to examine the influence of fundamental frequency (F0) and vocal tract length (VTL) modifications on speaker gender recognition in cochlear implant (CI) recipients for different stimulus types. Method Single words and sentences were manipulated using isolated or combined F0 and VTL cues. Using an 11-point rating scale, CI recipients and listeners with normal hearing rated the maleness/femaleness of the corresponding voice. Results Speaker gender ratings for combined F0 and VTL modifications were similar across all stimulus types in both CI recipi... περισσότερα »
Embedded Instruction Improves Vocabulary Learning During Automated Storybook Reading Among High-Risk Preschoolers
Purpose We investigated a small-group intervention designed to teach vocabulary and comprehension skills to preschoolers who were at risk for language and reading disabilities. These language skills are important and reliable predictors of later academic achievement. Method Preschoolers heard prerecorded stories 3 times per week over the course of a school year. A cluster randomized design was used to evaluate the effects of hearing storybooks with and without embedded vocabulary and comprehension lessons. A total of 32 classrooms were randomly assigned to experimental and compariso... περισσότερα »
On Older Listeners' Ability to Perceive Dynamic Pitch
Purpose Natural speech comes with variation in pitch, which serves as an important cue for speech recognition. The present study investigated older listeners' dynamic pitch perception with a focus on interindividual variability. In particular, we asked whether some of the older listeners' inability to perceive dynamic pitch stems from the higher susceptibility to the interference from formant changes. Method A total of 22 older listeners and 21 younger controls with at least near-typical hearing were tested on dynamic pitch identification and discrimination tasks using synthetic mon... περισσότερα »
Continuous Performance Tasks: Not Just About Sustaining Attention
Purpose Continuous performance tasks (CPTs) are used to measure individual differences in sustained attention. Many different stimuli have been used as response targets without consideration of their impact on task performance. Here, we compared CPT performance in typically developing adults and children to assess the role of stimulus processing on error rates and reaction times. Method Participants completed a CPT that was based on response to infrequent targets, while monitoring and withholding responses to regular nontargets. Performance on 3 stimulus conditions was compared: vis... περισσότερα »
Seeing the Talker's Face Improves Free Recall of Speech for Young Adults With Normal Hearing but Not Older Adults With Hearing Loss
Purpose Seeing the talker's face improves speech understanding in noise, possibly releasing resources for cognitive processing. We investigated whether it improves free recall of spoken two-digit numbers. Method Twenty younger adults with normal hearing and 24 older adults with hearing loss listened to and subsequently recalled lists of 13 two-digit numbers, with alternating male and female talkers. Lists were presented in quiet as well as in stationary and speech-like noise at a signal-to-noise ratio giving approximately 90% intelligibility. Amplification compensated for loss of au... περισσότερα »
Mechanism of 17{alpha},20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1. 18O-Labeling and Oxygen Surrogate Evidence for a Role of a Perferryl Oxygen Metabolism
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cytochrome P450 (P450) reactions can involve C-C bond cleavage, and several of these are critical in steroid and sterol biosynthesis. The mechanisms of P450s 11A1, 17A1, 19A1, and 51A1 have been controversial, in the context of the role of ferric peroxide (FeO2-) vs. perferryl (FeO3+, Compound I) chemistry. We reinvestigated the 17α-hydroxyprogesterone and 17α-hydroxypregnenolone 17α,20-lyase […]
Role of WW domain-containing oxidoreductase WWOX in driving T-cell acute lymphoblastic leukemia maturation Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Whether tumor suppressor WWOX stimulates immune cell maturation is largely unknown. Here, we determined that Tyr33-phosphorylated WWOX physically binds non-phosphorylated ERK and IκBα; in immature acute lymphoblastic leukemia MOLT-4 T cell and in the naive mouse spleen. The IκBα/ERK/WWOX complex was shown to localize, in part, in the mitochondria. WWOX prevents IκBα from proteosomal degradation. […]
Reactive oxygen species affects transglutaminase activity and regulates hematopoiesis in a crustacean Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Reactive oxygen species (ROS) serve as a prime signal in the commitment to hematopoiesis in both mammals and Drosophila. In the present study, the potential function of ROS during hematopoiesis in the crayfish Pacifastacus leniusculus was examined. The antioxidant, N-acetylcysteine (NAC), was used to decrease ROS in both in vivo and in vitro experiments. An […]
Structural basis for simvastatin competitive antagonism of complement receptor 3 Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The complement system is an important part of the innate immune response to infection, but may also cause severe complications during inflammation. Small molecule antagonists to complement receptor (CR)3 have been widely sought, but a structural basis for their mode of action is not available. We report here on the structure of the human CR3 […]
Desialylation of spermatozoa and epithelial cell glycocalyx is a consequence of bacterial infection of the epididymis Glycobiology and Extracellular Matrices
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Urinary tract infections caused by uropathogenic Escherichia coli (UPEC) pathovars belong to the most frequent infections in human. In men, pathogens can also spread to the genital tract via the continuous ductal system eliciting bacterial prostatitis and/or epididymo-orchitis. Antibiotic treatment usually clears pathogens in acute epididymitis, however, patients fertility can be permanently impaired. Since premature […]
Asn347-glycosylation of corticosteroid binding globulin fine-tunes the host immune response by modulating proteolysis by P. aeruginosa and neutrophil elastase Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Corticosteroid binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues upon elastase-based proteolysis of the exposed reactive center loop (RCL). However, the molecular mechanisms that regulate the RCL proteolysis by co-existing host and bacterial elastases in inflamed/infected tissues remain unknown. We document that RCL-localized Asn347-glycosylation fine-tunes the RCL cleavage rate by human neutrophil elastase (NE) […]
OEP40: a Regulated Glucose-Permeable, {beta}-Barrel Solute Channel in the Chloroplast Outer Envelope Membrane Plant Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Chloroplasts and mitochondria are unique endosymbiotic cellular organelles surrounded by two membranes. Essential metabolic networking between these compartments and their hosting cells requires the exchange of a large number of biochemical pathway intermediates in a directed and coordinated fashion across their inner and outer envelope membranes. Here we describe the identification and functional characterization of […]
Rescue of Fads1 knockout mouse
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A significant increase in cyclooxygenase 2 (COX2) gene expression has been shown to promote cylcooxygenase-dependent colon cancer development. Controversy associated with the role of COX2 inhibitors indicates that additional work is needed to elucidate the effects of arachidonic acid (AA) derived (cyclooxygenase and lipoxygenase) eicosanoids in cancer initiation, progression and metastasis. We have recently developed […]
Identification of CYP17A1 as a biomarker for HCC Detection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Early detection of hepatocellular carcinoma (HCC) is critical for successful treatment and favorable prognosis. To identify novel HCC biomarkers, we employed the WHV/c-myc transgenic (Tg) mice, an animal model of hepatocarcinogenesis. By analyzing their gene expression profiling, we investigated differentially expressed genes in livers of wild type and Tg mice. The cytochrome P450, family 17, […]
Osteopontin and Hepatocellular Carcinoma Risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between pre-diagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested-case control study was conducted within the EPIC cohort. During a mean follow-up of 4.8 years, 100 […]
Spatially dense morphometrics of craniofacial sexual dimorphism in 1-year-olds
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Recent advances in the field of geometric morphometrics allow for powerful statistical hypothesis testing for effects of biological and environmental variables on anatomical shape. This study used partial least-squares regression (PLSR) and the recently developed bootstrapped response-based imputation modelling (BRIM) algorithm to test for sexual dimorphism in the craniofacial shape of 1-year-old humans. We […]
Tooth-colored Dental Fillings – South Ogden, UT – South Ogden Smiles
The post Tooth-colored Dental Fillings – South Ogden, UT – South Ogden Smiles appeared first on Family Dentistry and Cosmetic Surgery Clinic. http://ift.tt/28QIlbh
Moral Failure: On the Impossible Demands of Morality, by Lisa Tessman.
from #Medicine via ola Kala on Inoreader http://ift.tt/28SR8uA via IFTTT
Geometric Possibility, by Gordon Belot.
from #Medicine via ola Kala on Inoreader http://ift.tt/2912iKO via IFTTT
The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial
Hypertension is a global health concern for which novel treatment strategies are necessary. The aim of this study is to evaluate the efficacy of resveratrol (trans-3, 5, 4′-trihydroxystilbene, a polyphenol pre... from #Medicine via ola Kala on Inoreader http://ift.tt/28SQZaD via IFTTT
SIRT3 gene expression but not subcellular localization is altered in response to fasting and exercise in human skeletal muscle
The present study examined SIRT3 expression and mitochondrial localization in response to acute exercise and short-term fasting in human skeletal muscle. Experiment 1 involved 8 healthy men (age, 21.4 ± 2.8 years; VO2peak, 47.1 ± 11.8 ml min−1 kg−1) who performed a single bout of exercise at ∼55% of peak aerobic work rate for 1 h. Muscle biopsies were obtained at rest (Rest), immediately after exercise (EX-0), and 3 h post-exercise (EX-3). Experiment 2 involved 10 healthy men (age, 22.0 ± 1.5 years; VO2peak, 47.2 ± 6.7 ml min−1 kg−1) who underwent a 48-hour fast, with muscle biop... περισσότερα »
Metformin Alleviates Altered Erythrocyte Redox Status During Aging in Rats
Rejuvenation Research , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/28Q6om9 via IFTTT
Psychosis Following an Increase in Intrathecal Baclofen
Baclofen is a commonly used medication to treat spasticity in neurologic disorders. In the traumatic brain injury population, the intrathecal administration of baclofen is often preferred over oral administration due to cognitive side effects. Here we report on a case of a psychotic episode following an increase in intrathecal baclofen in a young man with a history of a traumatic brain injury (TBI). While intrathecal baclofen is commonly used and generally well tolerated, this case highlights an important potential effect of intrathecal baclofen, rarely reported in the literature. ... περισσότερα »
OnabotulinumtoxinA injection for post-stroke upper-limb spasticity: Guidance for early injectors from a Delphi panel process
OnabotulinumtoxinA reduces muscle hypertonia associated with post-stroke spasticity (PSS). PSS manifests as several common postures. from #Medicine via ola Kala on Inoreader http://ift.tt/28SoHwK via IFTTT
Exercise Benefits for Chronic Low Back Pain in Overweight and Obese Individuals
Overweight and obese individuals with chronic low back pain (LBP) struggle with the combined physical challenges of physical activity and pain interference during daily life; perceived disability increases, pain symptoms worsen, and performance of functional tasks and quality of life (QOL) decline. Consistent participation in exercise programs positively affects several factors including musculoskeletal pain, perceptions of disability due to pain, functional ability, QOL, and body composition. It is not yet clear, however, what differential effects occur among different easily acc... περισσότερα »
Prevalence and Nature of Hearing Loss in 22q11.2 Deletion Syndrome
Purpose The purpose of this study was to clarify the prevalence, type, severity, and age-dependency of hearing loss in 22q11.2 deletion syndrome. Method Extensive audiological measurements were conducted in 40 persons with proven 22q11.2 deletion (aged 6–36 years). Besides air and bone conduction thresholds in the frequency range between 0.125 and 8.000 kHz, high-frequency thresholds up to 16.000 kHz were determined and tympanometry, acoustic reflex (AR) measurement, and distortion product otoacoustic emission (DPOAE) testing were performed. Results Hearing loss was identified in 59... περισσότερα »
