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EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors: BackgroundModerate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%–15% false negative diagnoses of leptomeningeal...
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A prospective trial of dynamic contrast-enhanced MRI perfusion and fluorine-18 FDG PET-CT in : BackgroundThe aim of this study was to assess the effectiveness of fluorine-18 fluorodeoxyglucose (FDG) PET-CT and dynamic contrast-enhanced (DCE) MRI in differentiating tumor progression and radiation injury...
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from lung cancer: AbstractAimTo evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for brain metastases (BMs) from lung cancer, and to explore prognostic factors associated with local control (LC) and indication.Patients and methodsWe evaluated patients who were...
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Phase I safety and pharmacokinetic dose-escalation study of AbstractPurposePilaralisib (SAR245408), a pan-class I PI3K inhibitor, has been investigated in Phase I/II trials in several solid tumors and lymphomas in capsule and tablet formulations of polymorph A (capsule-A and tablet-A). This Phase I study...
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Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncologyvia Tumor BiologyAbstractMucosal melanoma (MM) is a rare type of cancer that differs significantly from cutaneous melanoma. In this study, we aimed to evaluate clinical and...
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(stage III–IV) – A review of current standards in Europevia ScienceDirect Publication: European Journal of CancerPublication date: June 2016Source:European Journal of Cancer, Volume 60Author(s): Mark Harries, Josep Malvehy, Céleste Lebbe, Louise Heron, Justyna Amelio, Zsolt Szabo, Dirk SchadendorfAims...
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Peritonitis following percutaneous gastrostomy tube insertions in children: AbstractBackgroundPercutaneous retrograde gastrostomy has a high success rate, low morbidity, and can be performed under different levels of sedation or local anesthesia in children. Despite its favourable safety profile, major...
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in nasopharyngeal carcinoma: A critical reviewvia Critical Reviews in Oncology/Hematology (open access)Publication date: Available online May 2016Source:Critical Reviews in Oncology/HematologyAuthor(s): Katherine Ting-Wei Lee, Juan-King Tan, Alfred King-yin Lam, Sook-Yee GanDespite significant medical...
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A prospective, randomized, controlled phase II study: A prospective, placebo controlled phase II trial was conducted to test the efficacy of Nerve Growth Factor (NGF) for the treatment of symptomatic temporal lobe necrosis (TLN).AbstractPurposeA prospective, placebo controlled phase II trial was conducted...
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http://www.rxlist.com/picato-drug/Picato® (ingenol mebutate) gel, 0.015% or 0.05% is a clear colorless gel for topical administration, which contains the active substance ingenol mebutate, an inducer of cell death.The chemical name of ingenol mebutate is: 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta...
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and in relation to clinical outcome, in Stockholm, Sweden.: Authors: Dalianis T, Grün N, Koch J, Vlastos A, Tertipis N, Nordfors C, Näsman A, Wendt M, Romanitan M, Bersani C, Munck-Wikland E, Ramqvist TAbstract OBJECTIVES: Hypopharyngeal cancer is a subset of head neck squamous cell carcinoma...
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Eccrine syringofibroadenomatosis of the reactive subtype occurring in chronic poorly-controlled psoriasis.: Authors: Heng YK, Pan JY, Tan SH, Tey HLAbstract Eccrine syringofibroadenomatosis (ESFA) is a rare adnexal tumor with acrosyringeal differentiation. Clinically, it can be mistaken for...
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Patients in a Hispanic Population: Methodological Procedures.P R Health Sci J. 2016;35(1):3-8Authors: Suárez E, González L, Pérez-Mitchell C, Ortiz AP, Ramírez-Sola M, Acosta J, Bernabe-Dones RD, González-Aquino C, Montes-Rodríguez I, Cadilla CLAbstractOBJECTIVE: The incidence of oral cavity and pharyngeal...
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Using Principal Component Analysis Based Unsupervised Feature ExtractionInt J Mol Sci. 2016;17(5)Authors: Taguchi YHAbstract MicroRNA(miRNA)-mRNA interactions are important for understanding many biological processes, including development, differentiation and disease progression, but their identification...
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in vitro and in vivoMol Med Rep.Authors: Li X, Li Z, Yang G, Pan ZAbstract Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR‑338‑3p has been examined to be downregulated...
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Authors: Li LY, Jiang H, Xie YM, Liao LD, Cao HH, Xu XE, Chen B, Zeng FM, Zhang YL, Du ZP, Chen H, Huang W, Jia W, Zheng W, Xie JJ, Li EM, Xu LYAbstract The paucity of new drugs for the treatment of esophageal squamous cell carcinoma (ESCC) limits the treatment options. This study characterized...
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treated with laser laryngeal conservation surgeryEcancermedicalscience. 2016;10:636Authors: Karkos PD, Dova S, Sotiriou S, Markou K, Kostopoulos IAbstract ΒACKGROUND: Synchronous multiple malignancies of the larynx are rare. We present a case here of synchronous primary laryngeal squamous cell...
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A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathwaysCancer Epidemiol. 2016 May;42:173-180Authors: Azad AK, Bairati I, Qiu X, Girgis H, Cheng L, Waggott D, Cheng D, Mirshams M, Ho...
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Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population: AbstractAimThe aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).Materials...
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Authors: Patel AB, Hinni ML, Pollei TR, Hayden RE, Moore EJAbstract OBJECTIVES: Alert the reader to the complication of severe dysphagia following transoral laser microsurgery (TLM) or transoral robotic surgery (TORS) for bilateral simultaneous or synchronous tonsillar squamous cell carcinoma....
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RRx-001, A novel dinitroazetidine radiosensitizer: SummaryThe ‘holy grail’ in radiation oncology is to improve the outcome of radiation therapy (RT) with a radiosensitizer—a systemic chemical/biochemical agent that additively or synergistically sensitizes tumor cells to radiation in the absence of significant...
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A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of SummaryIntroduction E7820 is an orally administered sulfonamide that inhibits alfa-2-integrin mRNA expression. Pre-clinically E7820 showed tumor anti-angiogenic effects in various tumor cell lines and xenograft mouse...
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Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumorsSummaryBackground This phase I study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, immunogenicity, and antitumor activity of pembrolizumab in Japanese...
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Successful human epidermal growth receptor 2-targeted therapy beyond disease progression for extramammary Paget’s diseaseSummaryExtramammary Paget’s disease is a malignant intraepithelial carcinoma, which constitutes less than 1 % of all vulvar malignancies. Surgical resection is the first treatment...
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Pharmacokinetic assessment of dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN) following administration through a gastrostomy feeding tube (GT).: Authors: Chiu JW, Chan K, Chen EX, Siu LL, Abdul Razak ARAbstract ...
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Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT: Intensity modulated radiotherapy (IMRT) has emerged as the favored radiation modality for the definitive and post operative treatment of locally advanced head...
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Efficacy, safety and tolerability of field treatment of actinic keratosis with ingenol mebutate 0.015 % gel: a single center case series: AbstractIntroductionActinic keratosis (AK) is a cutaneous intraepithelial neoplasm appearing within areas referred as ‘fields of cancerization’. AK can progress to...
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Impact of post-chemoradiotherapy superselective/selective neck dissection on patient reported quality of lifevia ScienceDirect Publication: Oral OncologyPublication date: July 2016Source:Oral Oncology, Volume 58Author(s): Kyle Wang, Robert J. Amdur, William M. Mendenhall, Rebecca Green, Shannon Aumer,...
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Phosphodiesterase Type 5 Inhibitors and the Risk of Melanoma Skin CancerEur Urol. 2016 May ;Authors: Lian Y, Yin H, Pollak MN, Carrier S, Platt RW, Suissa S, Azoulay LAbstract BACKGROUND: The association between phosphodiesterase type 5 inhibitors (PDE5-Is), drugs used in the treatment of erectile...
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Cutaneous manifestations associated with malignancy of the head and neckSemin Oncol. 2016 Jun;43(3):353-8Authors: Lorimer P, Milas ZAbstract Most cutaneous malignancies of the head and neck (HN) are non-melanoma skin cancers, predominantly basal cell carcinomas (BCCs) and squamous cell carcinomas...
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2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Oncol Res. 2016;24(1):55-64Authors: Sobhakumari A, Orcutt KP, Love-Homan L, Kowalski CE, Parsons AD, Knudson CM, Simons ALAbstract Poor tumor response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is...
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Phase II randomized trial of Ann Oncol. 2016 May 13;Authors: Argiris A, Bauman JE, Ohr J, Gooding WE, Heron DE, Duvvuri U, Kubicek GJ, Posluszny DM, Vassilakopoulo M, Kim S, Grandis JR, Johnson JT, Gibson MK, Clump DA, Flaherty JT, Chiosea SI, Branstetter B, Ferris RLAbstract BACKGROUND: We previously...
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a single institution reviewAm J Otolaryngol. 2016 May-Jun;37(3):279-85Authors: Karatayli-Ozgursoy S, Bishop JA, Hillel AT, Akst LM, Best SRAbstract AIM: Non-epithelial tumors of the larynx are rare and encompass a wide range of pathology. We present the decade-long experience of a single institution...
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Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection: A monocentric retrospective analysis: The goals of the present study were to analyze survival data of patients who received salvage surgery due to recurrent oral squamous cell carcinoma (OSCC) of the oral cavity...
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The effect of device use after sequential bilateral cochlear implantation in children: An electrophysiological approachvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Marloes Sparreboom,...
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: Relationship to otoscopic findingsvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Jacob Pitaro, Laila Al Masaoudi, Hamid Motallebzadeh, W. Robert J. Funnell, Sam J. DanielObjectivesNewborn...
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: A new classification systemvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Cláudia Schweiger, Denise Manica, Gabriel Kuhl, Leo Sekine, Paulo José Cauduro MarosticaObjectiveTo compare...
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Association of serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization, respectively: A 2-year follow-up studyvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric...
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Topical versus oral antibiotics, with or without corticosteroids, in via International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Jeremy Chee, Khang Wen Pang, Jui May Yong, Roger Chun-Man Ho, Raymond...
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Evaluation of olfactory function in children with allergic rhinitis and nonallergic rhinitisvia International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Seyhan Kutlug, Emre Gunbey, Ayhan Sogut,...
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Routine Anti-Helicobacter Immunohistochemical Staining is Significantly Superior to Reflex Staining Protocols for the Detection of Helicobacter in Gastric Biopsy Specimens: AbstractBackgroundThe role of special stains in the detection of H. pylori is controversial; some pathologists claim that hematoxylin...
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Systematic review of ObjectivesTo compare the treatment outcomes and adverse event rates for primary closure compared to simple excision with healing by secondary intention for persistent tracheocutaneous fistula (TCF) in children.Study DesignSystematic review.MethodsSystematic review using Preferred...
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Update in the management of the middle vault in rhinoplasty.: Purpose of review: The middle vault of the nose continues to be a topic of interest among surgeons interested in aesthetic and functional rhinoplasty. The purpose of this review is to present currently accepted concepts regarding the significance...
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Assessment and Management of Laryngeal Mucous Membrane Pemphigoid: Our Experience in Six Patients and a Proposed Severity Scale: Mucous membrane pemphigoid (MMP) comprises a heterogenous spectrum of rare subepithelial blistering disorders affecting characteristic tissues throughout the body1. The prevalence...
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Our long-term experience in twenty patients: The vertical juxtaposition junction (VJJ) flap is a useful adjunct to the technique of mastoid obliteration and is readily created during the process of cartilage graft harvesting from the conchal bowl.It allows for greater inward rotation of a Palva flap...
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Systematic review of the diagnostic value of laryngeal stroboscopy in excluding early glottic carcinoma:AbstractObjectiveLaryngeal stroboscopy is an important diagnostic tool in the work-up of patients with phoniatric complaints. The aim of this article is to evaluate the diagnostic value of laryngeal...
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The effect of clinical setting on the unstimulated salivary flow ratevia Oral BiologyPublication date: September 2016Source:Archives of Oral Biology, Volume 69Author(s): Elena Maria Varoni, Veronica Federighi, Sem Decani, Antonio Carrassi, Giovanni Lodi, Andrea SardellaObjectiveUnstimulated whole saliva...
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S tudy of Ulcero-membranous Lesions of Tonsil in an Indian Scenario: Abstract‘Ulcero-membranous lesions over tonsil’ is a special entity, which puzzles every physician and surgeon because of it’s diverse etiology. Every insult to the tonsil heals by ulcer and later membrane formation. A retrospective...
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The Novel Use of the Laparoscopic Bipolar Vessel Sealing System in Endoscopic Laryngeal Surgery: Laryngeal Cyst ResectionThis is “Laryngeal Cyst Resection” by on Vimeo, the home for high quality videos and the people who love them.Jay K. Ferrell, MD; Benjamin Yang, MD; Uma Ramaswamy, MD; Ronda E. Alexander,...
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FRESH Noise - A Fresh Approach to Pediatric Testing: Keeley Moore: FRESH noise, or frequency-specific hearing assessment noise, is a narrowband noise (NBN) stimulus designed for the purpose of measuring hearing thresholds. It is frequency specific due to extremely steep filter slopes. Because of these...
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Keeley Moore: FRESH noise, or frequency-specific hearing assessment noise, is a narrowband noise (NBN) stimulus designed for the purpose of measuring hearing thresholds. It is frequency specific due to extremely steep filter slopes. Because of these steeply sloping filters slopes, the stimulus does not...
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Abstract Background Among the different mechanisms involved in irritable bowel syndrome (IBS) physiopathology, visceral hypersensitivity seems to play a key role. It involves sensitization of the colonic primary afferent fibers, especially through an overexpression of ion channels. The aims of...
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Abstract Background Gastroparesis is a poorly understood, chronic, debilitating motility disorder with very limited medical therapeutic options. Gastric peroral endoscopic pyloromyotomy (G-POEM) is an emerging novel endoscopic technique as an incisionless pyloroplasty for refractory cases. Effective...
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Laryngeal Cyst Resection This is "Laryngeal Cyst Resection" by on Vimeo, the home for high quality videos and the people who love them. Jay K. Ferrell, MD; Benjamin Yang, MD; Uma Ramaswamy, MD; Ronda E. Alexander, MD Ibrahim Alava III, MD Objective: To report our preliminary experience highlighting...
