Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia RESEARCH ARTICLE
Dörte Poburski, Josefine Barbara Boerner, Michel Koenig, Michael Ristow, and Rene Thierbach Friedreich ataxia is a neurodegenerative disease caused by a GAA triplet repeat expansion in the first intron of the frataxin gene, which results in reduced expression levels of the corresponding protein. Despite numerous animal and cellular models, therapeutic options that mechanistically address impaired… Continue reading Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia RESEARCH ARTICLE
Aneurisma de vena yugular interna
Aneurisma de vena yugular interna In Press, Corrected Proof, Available online 13 May 2016 Mariel S. Riedemann Wistuba, Amer A. Zanabili Al-Sibbai, Lino Camblor Santervás First page PDF Purchase PDF – $35.95 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23RSdCy via IFTTT
Síndrome trófico trigeminal
: causa infrecuente de ulceración nasal via Acta Otorrinolaringológica Española Publication date: Available online 13 May 2016 Source:Acta Otorrinolaringológica Española Author(s): Carlos Morales-Raya, Esther García-González, Lidia Maroñas-Jiménez from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23RSg1a via IFTTT
Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras RESEARCH ARTICLE
Margaret A. Keighren, Jean H. Flockhart, and John D. West The mouse Gpi1 gene encodes the glycolytic enzyme glucose phosphate isomerase. Homozygous Gpi1–/– null mouse embryos die but a previous study showed that some homozygous Gpi1–/– null cells survived when combined with wild-type cells in fetal chimaeras. One adult female Gpi1–/–Gpi1c/c chimaera with functional Gpi1–/–… Continue reading Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras RESEARCH ARTICLE
Ausencia de translocaciones cromosómicas y de expresión proteica de ALK en los adenocarcinomas nasosi nusales
Ausencia de translocaciones cromosómicas y de expresión proteica de ALK en los adenocarcinomas nasosinusales via Acta Otorrinolaringológica Española Publication date: Available online 13 May 2016 Source:Acta Otorrinolaringológica Española Author(s): Esteban Pacheco, José Luis Llorente, Alejandro López-Hernández, Cristina García-Inclán, María Costales, Sira Potes Ares, Fernando López, Blanca Vivanco, Mario A. Hermsen IntroducciónLas translocaciones de la región… Continue reading Ausencia de translocaciones cromosómicas y de expresión proteica de ALK en los adenocarcinomas nasosi nusales
C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress CORRECTION
Nisha Hirani, Marcel Westenberg, Paul T. Seed, Mark I. R. Petalcorin, and Colin T. Dolphin from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ThsosD via IFTTT
Timpanometría de alta frecuencia (1.000 Hz) en lactantes y su comparación con otoemisiones acústicas, otomicroscopia y timpanometría de 226 Hz
Timpanometría de alta frecuencia (1.000 Hz) en lactantes y su comparación con otoemisiones acústicas, otomicroscopia y timpanometría de 226 Hz Original Research Article In Press, Corrected Proof, Available online 13 May 2016 Eduardo A. Mena-Domínguez, José I. Benito-Orejas, Beatriz Ramírez-Cano, Darío Morais-Pérez, M. Fe Muñoz-Moreno Resumen Introducción y objetivo La timpanometría de baja frecuencia (226… Continue reading Timpanometría de alta frecuencia (1.000 Hz) en lactantes y su comparación con otoemisiones acústicas, otomicroscopia y timpanometría de 226 Hz
Osteosarcoma of head and neck
: A retrospective study on prognostic factors from a single institute database YiMing Chen1, , Qingcheng Shen1, , Sandhya Gokavarapu , Chengzhong Lin , Yahiya , Wei Cao , Shubhra Chauhan , Zheqi Liu , Tong Ji , Zhen Tian 1Equal first authors. Oral Oncology, Volume 58 Received: February 15, 2016; Received in revised form:… Continue reading Osteosarcoma of head and neck
Nasal septal schwannoma
: An extremely rare tumor via Acta Otorrinolaringológica Española Publication date: Available online 13 May 2016 Source:Acta Otorrinolaringológica Española Author(s): Konstantinos Valsamidis, Iokasti Koutsampasopoulou, Konstantinos Titelis from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TP8e6B via IFTTT
Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas
: Review of the literature Camelia Nami Saber1 , Christian Grønhøj Larsen1, , Tina Dalianis , Christian von Buchwald 1Shared first authorship. Oral Oncology, Volume 58 Received: January 13, 2016; Received in revised form: April 5, 2016; Accepted: April 12, 2016; Published Online:May 07, 2016 DOI: http://ift.tt/1sotB97 | Highlights •First review on immunological features of… Continue reading Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas
Efficacy of Elective Neck Dissection in T1/T2N0M0 Oral Tongue Squamous Cell Carcinoma: A Population-Based Analysis.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Related Articles *Efficacy of Elective Neck Dissection in T1/T2N0M0 Oral Tongue Squamous Cell Carcinoma: A Population-Based Analysis.* Otolaryngol Head Neck Surg. 2016 May 10; Authors: Patel TD, Vázquez A, Marchiano E, Sanghvi S, Eloy JA, Baredes S, Park RC Abstract OBJECTIVE/HYPOTHESIS: The aim of this population-based study is to analyze the survival benefits of elective neck dissection (END) over neck observation in T1/T2N0M0 oral tongue squamous cell carcinoma (OT-SCC) cases. STUDY DESIGN: Retrospective administrative database analysis. SUBJECTS AND METHODS: The SEER database ...περισσότερα »
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Related Articles *Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.* Otolaryngol Head Neck Surg. 2016 May 10; Authors: Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM Abstract OBJECTIVES: The use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. Here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy. DATA SOURCES: MEDLINE, PubMed Central, NCBI Bookshelf, Coch... περισσότερα »
Predictors of Failed and Delayed Decannulation after Head and Neck Surgery.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Related Articles *Predictors of Failed and Delayed Decannulation after Head and Neck Surgery.* Otolaryngol Head Neck Surg. 2016 May 10; Authors: Isaac A, Zhang H, Varshney S, Hamilton S, Harris JR, O'Connell DA, Biron VL, Seikaly H Abstract OBJECTIVE: To determine the variables that are predictive of failed decannulation (FD), delayed decannulation (DD), and days to decannulation in patients who underwent head and neck cancer resection with free tissue transfer reconstruction for head and neck squamous cell carcinoma. DESIGN: Case series with chart review. SETTING: Tertiary care ... περισσότερα »
Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Related Articles *Functional Outcomes after Salvage Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma.* Otolaryngol Head Neck Surg. 2016 May 10; Authors: Fink DS, Sibley H, Kunduk M, Schexnaildre M, Sutton C, Kakade-Pawar A, McWhorter AJ Abstract OBJECTIVES: Transoral laser microsurgery (TLM) has been increasingly used in lieu of total laryngectomy to treat malignancy after definitive radiation. There are few data in the literature regarding functional outcomes. We retrospectively reviewed voice and swallowing outcomes in patients who underwent TLM for recurrent... περισσότερα »
Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx treated with laser laryngeal conservation surgery.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
*Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx treated with laser laryngeal conservation surgery.* Ecancermedicalscience. 2016;10:636 Authors: Karkos PD, Dova S, Sotiriou S, Markou K, Kostopoulos I Abstract ΒACKGROUND: Synchronous multiple malignancies of the larynx are rare. We present a case here of synchronous primary laryngeal squamous cell carcinoma (SCC) and malignant fibrous histiocytoma (MFH) in a patient with hoarseness though with no history of exposure to radiation. Clinical, intraoperative, and histopathological findings in thi... περισσότερα »
Brain waves predict speed of second language learning
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
For the first time, researchers show that a 5-minute electroencephalography of resting-state brain activity can predict how fast adults learn a second language. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1sdIcDB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Jiangsu Pharmacertical and Clinical Research, Year 2016, Issue 02 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Jiangsu Pharmacertical and Clinical Research. Year 2016 Issue 02 is now available on CAOD. In this issue: Anti-Lewis Lung Cancer Immunity by Tumor Cell Lysate-sensitized Dendritic Cell Vaccines […]
Journal of Pediatric Pharmacy, Year 2016, Issue 05 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Pediatric Pharmacy. Year 2016 Issue 05 is now available on CAOD. In this issue: Effect of Ulinastatin on C-Reactive Protein and T-Lymphocyte Subsets in Children with […]
World Phytomedicines, Year 2016, Issue 04 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for World Phytomedicines. Year 2016 Issue 04 is now available on CAOD. In this issue: Synthetic technology of molidustat (molidustat的合成工艺研究) WEI Hui-qiang, LIU Yang, YU Jiang, SHANG Hai-hua, FAN […]
Pharmaceutical Journal of Chinese People’s Liberation Army, Year 2016, Issue 02 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Pharmaceutical Journal of Chinese People’s Liberation Army. Year 2016 Issue 02 is now available on CAOD. In this issue: zhong guo yao dian 2015 nian ban yao yong […]
Journal of Oral Science Research, Year 2016, Issue 04 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Oral Science Research. Year 2016 Issue 04 is now available on CAOD. In this issue: Effects of Staining Solutions on Color,Translucency,and Surface Roughness of Contemporary Resin […]
Medical Journal of National Defending Forces in Northwest China, Year 2016, Issue 04 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Medical Journal of National Defending Forces in Northwest China. Year 2016 Issue 04 is now available on CAOD. In this issue: Effects of hedysarum polysaccharides on expression of […]
Chinese Journal of Pharmacoepidemiology, Year 2016, Issue 04 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 40 δευτερόλεπτα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Pharmacoepidemiology. Year 2016 Issue 04 is now available on CAOD. In this issue: Relationship Between Vancomycin Trough Serum Concentrations and Clinical Outcomes:A Systematic Review and […]
A robust generalized sidelobe canceller via steering vector estimation
In the presence of the direction of arrival (DOA) mismatch, the performance of generalized sidelobe canceller (GSC) may suffer severe degradation due to the gain loss of the desired signal in the main array an... from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1WyARLx via IFTTT
N , N -dimethyl-2-phenylpropan-1-amine quantification in urine: application to excretion study following single oral dietary supplement dose
Abstract *N*,*N*-dimethyl-2-phenylpropan-1-amine (NN-DMPPA) is a new designer stimulant prohibited in sport in-competition according to the List of Prohibited Substances and Methods published by the World Anti-Doping Agency (WADA). The first published data on the excretion study of NN-DMPPA to support the knowledge of NN-DMPPA in routine anti-doping control have been presented. The reliable gas chromatography-mass spectrometry quantitative method (GC-MS) has been validated and applied to the excretion study of NN-DMPPA. The validation parameters of the GC-MS method for determinatio... περισσότερα »
Two-dimensional mass defect matrix plots for mapping genealogical links in mixtures of lignin depolymerisation products
Abstract Lignin is the second most abundant natural biopolymer, and lignin wastes are therefore potentially significant sources for renewable chemicals such as fuel compounds, as alternatives to fossil fuels. Waste valorisation of lignin is currently limited to a few applications such as in the pulp industry, however, because of the lack of effective extraction and characterisation methods for the chemically highly complex mixtures after decomposition. Here, we have implemented high resolution mass spectrometry and developed two-dimensional mass defect matrix plots as a data visua... περισσότερα »
Modelling the needling effect on the stress concentrations of laminated C/C composites
Publication date: 15 August 2016 *Source:*Materials & Design, Volume 104 Author(s): Yongzhen Jia, Dunming Liao, Hong Cui, Alin Ji, Xia Bai, Muhammad Yasir The initial stress concentration resulting from the needle-punching effect is a fundamental issue in the longitudinal strength model for laminated carbon/carbon composites. In the present work, this stress distribution is obtained by combining the finite difference method with the shear-lag model. The effect of the needled hole size on the stress concentration is investigated. The broken width is more significant than the separate... περισσότερα »
Headspace-programmed temperature vaporization-mass spectrometry for the rapid determination of possible volatile biomarkers of lung cancer in urine
Abstract We propose a new method for the rapid determination of five volatile compounds described in the literature as possible biomarkers of lung cancer in urine samples. The method is based on the coupling of a headspace sampler, a programmed temperature vaporizer in solvent-vent injection mode, and a mass spectrometer (HS-PTV-MS). This configuration is known as an electronic nose based on mass spectrometry. Once the method was developed, it was used for the analysis of urine samples from lung cancer patients and healthy individuals. Multivariate calibration models were employed ... περισσότερα »
Dynamic Baseline Variations and Drug Sensitivity
Dynamic Baseline Variations and Drug Sensitivity: Cell-to-cell variations contribute to drug resistance with consequent therapy failure in cancer. Experimental techniques have been developed to monitor tumor heterogeneity, but estimates of cell-to-cell variation typically fail to account for the expected spatiotemporal variations during the cell growth process. To fully capture the extent of such dynamic variations, we developed a mechanistic mathematical model supported by in vitro experiments with an ovarian cancer cell line. We introduce the notion of dynamic baseline cell-to-cell... περισσότερα »
CD4+ T-cell Help in Therapeutic Cancer Vaccination
CD4+ T-cell Help in Therapeutic Cancer Vaccination: While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4+ T cells improve CTL responsiveness, next-generation vaccines include helper epitopes. Here, we demonstrate in mice how CD4+ T-cell help optimizes the CTL response to a clinically relevant DNA vaccine engineered to combat human papillomavirus–expr... περισσότερα »
Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer
Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer: AbstractOlfactomedin 4 (OLFM4) is an olfactomedin domain-containing glycoprotein. Multiple signaling pathways and factors, including NF-κB, Wnt, Notch, PU.1, retinoic acids, estrogen receptor, and miR-486, regulate its expression. OLFM4 interacts with several other proteins, such as gene associated with retinoic-interferon-induced mortality 19 (GRIM-19), cadherins, lectins, nucleotide oligomerization domain-1 (NOD1) and nucleotide oligomerization domain-2 (NOD2), and cathepsins C and D, known to ... περισσότερα »
Efficacy of the neurokinin-1 receptor antagonist rolapitant in preventing nausea and vomiting in patients receiving carboplatin-based chemotherapy
Efficacy of the neurokinin-1 receptor antagonist rolapitant in preventing nausea and vomiting in patients receiving carboplatin-based chemotherapy: BACKGROUND Rolapitant, a novel neurokinin-1 receptor antagonist, provided effective protection against chemotherapy-induced nausea and vomiting (CINV) in a randomized, double-blind phase 3 trial of patients receiving moderately emetogenic chemotherapy or an anthracycline and cyclophosphamide regimen. The current analysis explored the efficacy and safety of rolapitant in preventing CINV in a subgroup of patients receiving carboplatin... περισσότερα »
Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia): A Preliminary Clinical Study
Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia): A Preliminary Clinical Study: *Hypothesis*. Prior studies on patients with early B-cell lymphoid malignancies suggest that early intervention with curcumin may lead to delay in progressive disease and prolonged survival. These patients are characterized by increased susceptibility to infections. Rice bran arabinoxylan (Ribraxx) h... περισσότερα »
Curculigo orchioides Gaertn Effectively Ameliorates the Uro- and Nephrotoxicities
Induced by Cyclophosphamide Administration in Experimental Animals: *Background*. *Curculigo orchioides* Gaertn is an ancient medicinal plant (Family: Amaryllidaceae), well known for its immunomodulatory and rejuvenating effects. Cyclophosphamide (CPA) is an alkylating agent widely used for treating a variety of human malignancies, but associated with different toxicities too. Our previous reports regarding the hemoprotective and hepatoprotective effects of the plant against CPA toxicities provide the background for the present study, which is designed to analyze the ameliorative ... περισσότερα »
Acupuncture-Like Transcutaneous Nerve Stimulation for Chemotherapy-Induced Peripheral Neuropathy
Phase 2 Study of A prospective phase 2 study was conducted to evaluate the clinical utility of acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a < 2 ECOG performance score, received neurotoxic chemotherapy, and developed CIPN symptoms for > two months. Randomization was used to eliminate bias in patient selection for ALTENS and was not to compare the effectiveness between the two treatments.ALTENS treatments were delivered using Codetron units. Bilateral acupuncture poi... περισσότερα »
Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology
Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases: *Introduction*. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. *Methods.* The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined. Tumor patholo... περισσότερα »
Radiation therapy, cetuximab and pemetrexed with or without bevacizumab in patients with locoregionally-advanced head and neck cancer
Phase II randomized trial of We previously reported the safety of the novel, non-platinum combination of cetuximab, pemetrexed and radiation therapy in head and neck cancer. Given extensive EGFR-VEGF pathway crosstalk, we conducted a randomized study evaluating this combination with or without bevacizumab. Both arms were superior to historical control, however, only the non-bevacizumab regimen is recommended for development. 1. A. Argiris1, 2. J.E. Bauman2,*, 3. J. Ohr3, 4. W.E. Gooding4, 5. D.E. Heron5, 6. U. Duvvuri6, 7. G.J. Kubicek7, 8. D.M. ... περισσότερα »
Somatic RET mutation in a patient with pigmented adrenal pheochromocytoma
Somatic RET mutation in a patient with pigmented adrenal pheochromocytoma: Summary Pheochromocytomas (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors arising from chromaffin cells of the neural crest. Mutations in the *RET*-proto-oncogene are associated with sporadic pheochromocytoma, familial or sporadic medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia type 2. In the past, only few cases of pigmented PCCs, PGLs, and one case of pigmented MTC have been reported in the literature. Herein, we present the case of a 77-year old woman with a history of Tako... περισσότερα »
High levels of circulating myeloid derived suppressor cells (MDSCs) in various cancer types, including melanoma
MDSCs' significance in ipilimumab treated melanoma patients: PURPORSE: High levels of circulating myeloid derived suppressor cells (MDSCs) in various cancer types, including melanoma, were shown to correlate with poor survival. We investigated whether frequencies of circulating CD33+CD11b+HLA-DR- MDSCs could be used as immune system monitoring biomarkers to predict response and survival of stage-IV melanoma patients treated with anti-CTLA4 (ipilimumab) therapy. EXPERIMENTAL DESIGN: Peripheral blood samples from 56 patients and 50 healthy donors (HD) were analyzed for CD33+CD11b+HLA... περισσότερα »
Smoking-related cancer
in military veterans: retrospective cohort study of 57,000 veterans and 173,000 matched non-veterans: Abstract BackgroundServing military personnel are more likely to smoke, and to smoke more heavily, than civilians. The aim of our study was to examine whether veterans have an increased risk of a range of smoking-related cancers compared with non-veterans, using a large, national cohort of veterans. MethodsWe conducted a retrospective cohort study of 57,000 veterans resident in Scotland and 173,000 age, sex and area of residence matched civilians. We used Cox proportional hazar... περισσότερα »
Hearing loss secondary to vestibular schwannoma growth
An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth: AbstractVestibular schwannoma is a benign neoplasm arising from the Schwann cell sheath of the auditory-vestibular nerve. It most commonly affects both sides in the genetic condition Neurofibromatosis type 2, causing progressive high frequency sensorineural hearing loss. Here, we describe a microsurgical technique and stereotactic coordinates for schwannoma cell grafting in the vestibular nerve region that recapitulates local tumor growth in the cerebellopontine angle and inner auditor... περισσότερα »
Iodine Uptake Patterns on Post-ablation Whole Body Scans
are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma: Abstract PurposeSerum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy. The authors studied the relationship between the elevation of serum Tg after RAI therapy and iodine uptake pattern on post-ablation whole body scans (RxWBSs) in patients with papillary thyroid carcinoma (PTC). Materials and MethodsThe study subjects were patients with PTC that had undergone first RAI therapy with thyroid horm... περισσότερα »
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients: Abstract BackgroundIt was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an earlier study that exposure of immortalized human embryonic kidney cells (HEK 293) to cancer patient sera, induce their transformation into undifferentiated cancers due to a horizontal transfer of malignant traits. In the present work, we tested ... περισσότερα »
Metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients: Abstract BackgroundIt was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an earlier study that exposure of immortalized human embryonic kidney cells (HEK 293) to cancer patient sera, induce their transformation into undifferentiated cancers due to a horizontal transfer of malignant traits. In the present work, we tested ... περισσότερα »
Statins and Risk of Bleeding
An Analysis to Evaluate Possible Bias Due to Prevalent Users and Healthy User Aspects: Statins are said to protect against a wide range of diseases. We studied to what extent potential bias influences the results of studies on beneficial side effects of statins. We selected 8,188 atrial fibrillation patients who started treatment with anticoagulants at the Leiden Anticoagulation Clinic in the Netherlands between 2003 and 2009 and experienced 1,683 minor and 451 major bleeds during 18,105 person-years of follow-up. Statins were associated with a risk reduction of 9% for bleeds (haza... περισσότερα »
Hemoglobin Concentration
Association of Hemoglobin Concentration With Total and Cause-Specific Mortality in a Cohort of Postmenopausal Women: Anemia and low and high levels of hemoglobin have been associated with increased mortality and morbidity. However, most studies have measured hemoglobin at only 1 time point, and few studies have considered possible reverse causation. We used data from the Women's Health Initiative, in which baseline hemoglobin was measured in 160,081 postmenopausal women and year 3 hemoglobin was measured in 75,658 participants, to examine the associations of hemoglobin concentratio... περισσότερα »
Primary Low Level of High-Density Lipoprotein Cholesterol
and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis: Prior studies observing associations between low levels of high-density lipoprotein (HDL) cholesterol and cardiovascular disease (CVD) have often been conducted among persons with metabolic or other lipid abnormalities. In this study, we investigated the association between primary low HDL cholesterol and coronary heart disease (CHD), CVD, and all-cause death after adjustment for confounders in the Multi-Ethnic Study of Atherosclerosis (MESA). Participant... περισσότερα »
Associations Between Vitamin D Level and Hospitalizations
With and Without an Infection in a National Cohort of Medicare Beneficiaries: Research has implicated low 25-hydroxyvitamin D (25(OH)D) level as a risk factor for infection; however, results have not been consistent. To further determine the nature of this relationship, we conducted a cohort study using Medicare beneficiaries participating in the 2001–2002 and 2003–2004 cycles of the National Health and Nutrition Examination Survey with data individually linked to hospital records from the Centers for Medicare and Medicaid Services. The primary exposure was a 25(OH)D level of <15 n... περισσότερα »
A 15-year-old Girl with an Asymmetric Hemitruncal Fat Distribution: Hemihyperthrophy or Hemiatrophy?
[image: image]Summary: A 15-year-old girl presented to the pediatrician with complaints of excessive fat distribution on the right side and breast asymmetry. At age 2, she had undergone a left-sided nephrectomy because of a stage III Wilms tumor using a transverse cut supraumbilical approach, followed by systemic chemotherapy and local radiotherapy. In the case of trunk asymmetry, it is questionable which side is deviant. The asymmetry may be an expression of isolated hemihyperthrophy, syndromal hemihypertrophy related to the Wilms tumor, or an expression of left-sided hemiatrophy a... περισσότερα »
No-drain DIEP Flap Donor-site Closure Using Barbed Progressive Tension Sutures
[image: image]Background: The use of progressive tension sutures has been shown to be comparable to the use of abdominal drains in abdominoplasty. However, the use of barbed progressive tension sutures (B-PTSs) in deep inferior epigastric artery perforator (DIEP) flap donor-site closure has not been investigated. Methods: A retrospective chart review was performed on patients with DIEP flap reconstruction in a 3-year period at 2 institutions by 2 surgeons. Patients were compared by method of DIEP donor-site closure. Group 1 had barbed running progressive tension sutures without drai... περισσότερα »
A case study of SMART attributes: a qualitative assessment of generalizability, retention rate, and trial quality
Personalizing medical care is becoming increasingly popular, particularly mental health care. There is growing interest in formalizing medical decision making based on evolving patient symptoms in an evidence-... from #Medicine via ola Kala on Inoreader http://ift.tt/1sacKGv Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial
Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked... from #Medicine via ola Kala on Inoreader http://ift.tt/1YsUAdr Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fwd: Jiangsu Pharmacertical and Clinical Research, Year 2016, Issue 02 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Jiangsu Pharmacertical and Clinical Research*. Year *2016* Issue *02* is now available on CAOD. *In this issue:* Anti-Lewis Lung Cancer Immunity by Tumor Cell Lysate-sensitized Dendritic Cell Vaccines with M2 and OK-432 in Mice (基于M2与OK-432的肿瘤细胞裂解物致敏的树突状细胞疫苗抗小鼠Lewis肺癌作用研究) GE Chi-yu, ZHOU Zhou, ZHANG Jun-li, School of Medicine and He alth Management, Jiangsu Food and Pharmaceutical Science College, Jian... περισσότερα »
Fwd: Journal of Pediatric Pharmacy, Year 2016, Issue 05 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Pediatric Pharmacy*. Year *2016* Issue *05* is now available on CAOD. *In this issue:* Effect of Ulinastatin on C-Reactive Protein and T-Lymphocyte Subsets in Children with Chronic Heart Failure (乌司他丁对慢性心力衰竭患儿C-反应蛋白、T细胞亚群和心功能的影响) Lyu Guiping, Traditional Chinese and Western Medicine Hospitals of Guangzhou ...... page:1-4 zhong guo ke ji lun wen tong ji yuan qi kan zhong guo ke ji he xin qi kan ... περισσότερα »
Fwd: World Phytomedicines, Year 2016, Issue 04 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *World Phytomedicines*. Year *2016* Issue *04* is now available on CAOD. *In this issue:* Synthetic technology of molidustat (molidustat的合成工艺研究) WEI Hui-qiang, LIU Yang, YU Jiang, SHANG Hai-hua, FAN Sai-jun, LI Yi-liang, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Departm... περισσότερα »
Fwd: Pharmaceutical Journal of Chinese People's Liberation Army, Year 2016, Issue 02 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Pharmaceutical Journal of Chinese People's Liberation Army*. Year *2016* Issue *02* is now available on CAOD. *In this issue:* zhong guo yao dian 2015 nian ban yao yong fu liao jian ce ji shu pei xun ban zai bei jing ju ban (《中国药典》2015年版药用辅料检测技术培训班在北京举办) WANG Zidong, HU Yigang ...... page:97 Protective Effect of Phenylethanoid Glycosides from Phlomis Younghusbandii and Regulation of Expression of VEGF in... περισσότερα »
Fwd: Journal of Oral Science Research, Year 2016, Issue 04 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Oral Science Research*. Year *2016* Issue *04* is now available on CAOD. *In this issue:* Effects of Staining Solutions on Color,Translucency,and Surface Roughness of Contemporary Resin Cements:an in vitro Study (外源性染色剂对树脂水门汀颜色、透明度和表面粗糙度影响的研究) CHENG Shao-long, YU Hao, CHEN Wei-ran, ZHENG Hai-yan, CHENG Hui, Key Laboratory of Stomatology, School and Hospital of Stomatology, Fujian Medical Univ... περισσότερα »
Fwd: Medical Journal of National Defending Forces in Northwest China, Year 2016, Issue 04 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Medical Journal of National Defending Forces in Northwest China*. Year *2016* Issue *04* is now available on CAOD. *In this issue:* Effects of hedysarum polysaccharides on expression of Bax/Bcl-2 and apoptosis in lung adenocarcinoma cells (红芪多糖诱导肺腺癌细胞凋亡与Bax/Bcl-2表达的研究) LIU Hua, YAN Liping, WANG Xiaojun, Department of Respiratory Diseases, Gansu Province Hospital ...... page:211-213 Correlation of AMH G14... περισσότερα »
Fwd: Chinese Journal of Pharmacoepidemiology, Year 2016, Issue 04 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Pharmacoepidemiology*. Year *2016* Issue *04* is now available on CAOD. *In this issue:* Relationship Between Vancomycin Trough Serum Concentrations and Clinical Outcomes:A Systematic Review and Meta-Analysis (万古霉素血药谷浓度和临床结局相关性的系统评价和Meta分析（英文）) Ye Zhikang, Chen Ken, Pleasants RA, Chen Yaolong, Zhai Suodi, Department of Pharmacy, Peking University Third hospital, Department of Pharmacy... περισσότερα »
Fwd: China Cancer, Year 2016, Issue 05 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *China Cancer*. Year *2016* Issue *05* is now available on CAOD. *In this issue:* Clinical and Epidemiological Features of Pancreatic Neuroendocrine Neoplasm in China,2001～2010 (2001~2010年中国胰腺神经内分泌肿瘤的临床流行病学特征分析) ZHANG Yu-qing, MA Li, HE Yu-tong, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Epidemiology, Dalian Medical Universi... περισσότερα »
A case-control study of medical, psychological and socio-economic factors influencing the severity of chronic rhinosinusitis.
*A case-control study of medical, psychological and socio-economic factors influencing the severity of chronic rhinosinusitis.* Rhinology. 2016 May 12; Authors: Philpott C, Erskine S, Hopkins C, Coombes E, Kara N, Sunkareneni V, Anari S, Salam M, Farboud A Abstract BACKGROUND: Chronic rhinosinusitis (CRS) is a common and debilitating disorder. Little is known about the epidemiology of this disease. The aims of the study were to identify differences in socio-economic variables and quality of life between patients with chronic rhinosinusitis and healthy controls, to identify any si... περισσότερα »
Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling
Publication date: 22 July 2016 Source:Neuroscience, Volume 328 Author(s): Yen-Ning Huang, Ching-I Lin, Hsiang Liao, Chin-Yu Liu, Yue-Hua Chen, Wan-Chun Chiu, Shyh-Hsiang Lin Epidemiological investigations have shown that Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases. It has been indicated that the cholesterol concentration in the brain of AD patients is higher… Continue reading Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling
Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies
Publication date: 22 July 2016 Source:Neuroscience, Volume 328 Author(s): Silke Miller, Hantao Liu, Karin Warfvinge, Licheng Shi, Mary Dovlatyan, Cen Xu, Lars Edvinsson Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein… Continue reading Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonis... περισσότερα »
Activity-dependent structural plasticity after aversive experiences in amygdala and auditory cortex pyramidal neurons
Publication date: 22 July 2016 Source:Neuroscience, Volume 328 Author(s): Tina Gruene, Katelyn Flick, Sam Rendall, Jin Hyung Cho, Jesse Gray, Rebecca Shansky The brain is highly plastic and undergoes changes in response to many experiences. Learning especially can induce structural remodeling of dendritic spines, which is thought to relate to memory formation. Classical Pavlovian fear… Continue reading Activity-dependent structural plasticity after aversive experiences in amygdala and auditory cortex pyramidal neurons
Identification and characterization of heptaprenylglyceryl phosphate processing enzymes in Bacillus subtilis Lipids
In Archaea, ether lipids play an essential role as the main building blocks of the cellular membrane. Recently, ether lipids have also been discovered in the domain of Bacteria, and the key enzymes that catalyze their synthesis, glycerol-1-phosphate dehydrogenase and heptaprenylglyceryl phosphate (HepGP) synthase, have been described. In Bacillales, HepGP does not become linked to… Continue reading Identification and characterization of heptaprenylglyceryl phosphate processing enzymes in Bacillus subtilis Lipids
Diagnostic biomarkers in venous thromboembolic disease
Venous thromboembolism (VTE) is a common disease with serious, often fatal sequelae. The optimal strategy for diagnosis of VTE remains unclear, although considerable progress has been made in this area. Several new biomarkers have showed promise for diagnosis of VTE, and more are under active investigation. We reviewed the literature for studies evaluating these diagnostic… Continue reading Diagnostic biomarkers in venous thromboembolic disease
The next frontier of office-based inferior vena cava filter placement
There is an increasing number of procedures that traditionally were performed in the inpatient setting that are now becoming office-based procedures. These include peripheral endovascular procedures such as angiograms, angioplasties, dialysis access interventions, and treatment for venous insufficiency. We chose to evaluate the feasibility, safety of inferior vena cava (IVC) filter placement in the office-based… Continue reading The next frontier of office-based inferior vena cava filter placement
Ruptured external jugular varix
Venous dilations of the jugular veins are uncommon and external jugular varix even rarer. We present the case of a 57-year-old woman with ruptured external jugular varix and the surgical repair of such. Surgical intervention is warranted in these rare venous malformations to prevent known complications of thromboembolism and rupture. from #Medicine-SfakianakisAlexandros via o.lakala70 on… Continue reading Ruptured external jugular varix
Brachial Artery Aneurysm and Thrombosis secondary to Fibromuscular Dysplasia
Fibromuscular dysplasia is a pathological process causing stenosis and dilatation of medium calibre arteries of unknown aetiology. It most commonly affects the renal and carotid arteries however it has been described in virtually all anatomical areas including, rarely, the brachial artery1. We describe a case of brachial artery aneurysm and thrombosis in a 29-year-old male… Continue reading Brachial Artery Aneurysm and Thrombosis secondary to Fibromuscular Dysplasia
Infestation of a diabetic foot by Wohlfahrtia Magnifica
Myiasis is the infestation of animals or humans by larvae from some species of dipteran flies. Dependig on the tissues invaded, the maggots of these insects can produce different diseases of the skin, or mucoses (ocular, genitourinary and oropharyngeal)1-4. Wohlfahrtia magnifica is one of the species causing myiasis that, although a real veterinary problem, rarely… Continue reading Infestation of a diabetic foot by Wohlfahrtia Magnifica
Associations Between Vitamin D Level and Hospitalizations
With and Without an Infection in a National Cohort of Medicare Beneficiaries: Research has implicated low 25-hydroxyvitamin D (25(OH)D) level as a risk factor for infection; however, results have not been consistent. To further determine the nature of this relationship, we conducted a cohort study using Medicare beneficiaries participating in the 2001–2002 and 2003–2004 cycles… Continue reading Associations Between Vitamin D Level and Hospitalizations
Dietary and Pharmacological Intervention to Mitigate the Cardiopulmonary Effects of Air Pollution Toxicity
Publication date: Available online 14 May 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects Author(s): Haiyan Tong BackgroundHuman exposure to air pollution has long been associated with excess morbidity and mortality. Although regulatory measures carried out under the “Clean Air Act” have saved millions of lives, there are still hundreds of thousands of people… Continue reading Dietary and Pharmacological Intervention to Mitigate the Cardiopulmonary Effects of Air Pollution Toxicity
Rapid estimation of readily leachable triazine residues in soils using automatic kinetic bioaccessibility assays followed by on-line sorptive clean-up as a front-end to liquid chromatography
Publication date: 15 August 2016 Source:Talanta, Volumes 156–157 Author(s): Ana C.F. Vida, David J. Cocovi-Solberg, Elias A.G. Zagatto, Manuel Miró An automatic batchwise bioaccessibility test was proposed for on-line monitoring of readily mobile pools of ametryn and atrazine residues in agricultural soils with different physicochemical properties. A 0.01molL−1 CaCl2 solution mimicking rainwater percolation through the… Continue reading Rapid estimation of readily leachable triazine residues in soils using automatic kinetic bioaccessibility assays followed by on-line sorptive clean-... περισσότερα »
New optical paper sensor for in situ measurement of hydrogen sulphide in waters and atmospheres
Publication date: 15 August 2016 Source:Talanta, Volumes 156–157 Author(s): J. Pla-Tolós, Y. Moliner-Martínez, J. Verdú-Andrés, J. Casanova-Chafer, C. Molins-Legua, P. Campíns-Falcó A novel and low-cost colorimetric sensor for the determination of hydrogen sulphide in environmental samples has been developed. This sensor is based on the immobilization of the reagent N,N-Dimethyl-p-phenylenediamine and FeCl3 in paper support,… Continue reading New optical paper sensor for in situ measurement of hydrogen sulphide in waters and atmospheres
Bio-assisted potentiometric multisensor system for purity evaluation of recombinant protein A
Publication date: 15 August 2016 Source:Talanta, Volumes 156–157 Author(s): Edita Voitechovič, Anton Korepanov, Dmitry Kirsanov, Igor Jahatspanian, Andrey Legin Recombinant proteins became essential components of drug manufacturing. Quality control of such proteins is routine task, which usually requires a lot of time, expensive reagents, specialized equipment and highly educated personnel. In this study we propose… Continue reading Bio-assisted potentiometric multisensor system for purity evaluation of recombinant protein A
Comparison of the solid-phase extraction efficiency of a bounded and an included cyclodextrin-silica microporous composite for polycyclic aromatic hydrocarbons determination in water samples
Publication date: 15 August 2016 Source:Talanta, Volumes 156–157 Author(s): Adela Mauri-Aucejo, Pedro Amorós, Alaina Moragues, Carmen Guillem, Carolina Belenguer-Sapiña Solid-phase extraction is one of the most important techniques for sample purification and concentration. A wide variety of solid phases have been used for sample preparation over time. In this work, the efficiency of a new… Continue reading Comparison of the solid-phase extraction efficiency of a bounded and an included cyclodextrin-silica microporous composite for polycyclic aromatic hydrocarbons determination in w... περισσότερα »
Spock, Benjamin
Spock, Benjamin: (1903-1998) American pediatrician whose book on «Baby and Child Care» which first appeared in 1946 was one of the biggest best-sellers of all time. It sold some 50 million copies. Its revolutionary message to parents was that «you know more than you think you do.» Spock gently coached parents to trust their «own… Continue reading Spock, Benjamin
Ultra-trace level speciated isotope dilution measurement of Cr(VI) using ion chromatography tandem mass spectrometry in environmental waters
Publication date: 15 August 2016 Source:Talanta, Volumes 156–157 Author(s): Stefanie Mädler, Aaron Todd, H.M. «Skip» Kingston, Matt Pamuku, Fengrong Sun, Cindy Tat, Robert J. Tooley, Teresa A. Switzer, Vasile I. Furdui The reliable analysis of highly toxic hexavalent chromium, Cr(VI), at ultra-trace levels remains challenging, given its easy conversion to non-toxic trivalent chromium. This work… Continue reading Ultra-trace level speciated isotope dilution measurement of Cr(VI) using ion chromatography tandem mass spectrometry in environmental waters
A case of lobar pneumonia and sepsis with death caused by invasive Klebsiella rhinoscleromatis infection
Publication date: Available online 14 May 2016 Source:Journal of Infection and Chemotherapy Author(s): Eri Kumade, Norihiro Furusyo, Norito Takeshima, Yasuhiro Kishihara, Fujiko Mitsumoto-Kaseida, Yoshitaka Etoh, Masayuki Murata, Jun Hayashi Klebsiella pneumoniae often causes pneumonia and other infections in heavy drinkers and patients with diabetes. Pneumonia caused by Klebsiella rhinoscleromatis, a subspecies of K. pneumoniae, has… Continue reading A case of lobar pneumonia and sepsis with death caused by invasive Klebsiella rhinoscleromatis infection
A case study of SMART attributes: a qualitative assessment of generalizability, retention rate, and trial quality
Personalizing medical care is becoming increasingly popular, particularly mental health care. There is growing interest in formalizing medical decision making based on evolving patient symptoms in an evidence-... from #Medicine via ola Kala on Inoreader http://ift.tt/1sacKGv via IFTTT
Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial
Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked... from #Medicine via ola Kala on Inoreader http://ift.tt/1YsUAdr via IFTTT
A case study of SMART attributes: a qualitative assessment of generalizability, retention rate, and trial quality
Personalizing medical care is becoming increasingly popular, particularly mental health care. There is growing interest in formalizing medical decision making based on evolving patient symptoms in an evidence-... from #Medicine via ola Kala on Inoreader http://ift.tt/1sacKGv Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial
Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked... from #Medicine via ola Kala on Inoreader http://ift.tt/1YsUAdr Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Determination of phytate in high molecular weight, charged organic matrices by two-dimensional size exclusion-ion chromatography
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Kyle R. Elkin, Rosanne Slingsby, Ray B. Bryant A two-dimensional chromatography method for analyzing phytate or other ionic targets in matrices containing high molecular weight, charged organic species is described. Prior to quantification by anion exchange chromatography, the sample matrix was prepared by size exclusion chromatography, which removed the majority of the matrix. Quantification of phytate on the AS11-HC was sensitive (0.25µM, 0.17mg/l) and reproducible (4.6% RSD) allowing this method to prov... περισσότερα »
Rapid estimation of readily leachable triazine residues in soils using automatic kinetic bioaccessibility assays followed by on-line sorptive clean-up as a front-end to liquid chromatography
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Ana C.F. Vida, David J. Cocovi-Solberg, Elias A.G. Zagatto, Manuel Miró An automatic batchwise bioaccessibility test was proposed for on-line monitoring of readily mobile pools of ametryn and atrazine residues in agricultural soils with different physicochemical properties. A 0.01molL−1 CaCl2 solution mimicking rainwater percolation through the soil profiles was used for the herbicide extractions. The extract aliquots were successively sampled at regular time intervals in order to investigate the extracti... περισσότερα »
New optical paper sensor for in situ measurement of hydrogen sulphide in waters and atmospheres
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): J. Pla-Tolós, Y. Moliner-Martínez, J. Verdú-Andrés, J. Casanova-Chafer, C. Molins-Legua, P. Campíns-Falcó A novel and low-cost colorimetric sensor for the determination of hydrogen sulphide in environmental samples has been developed. This sensor is based on the immobilization of the reagent N,N-Dimethyl-p-phenylenediamine and FeCl3 in paper support, in which the H2S is adsorbed in order to give rise to the formation of methylene blue as reaction product.The sensor has been applied to determine H2S in wate... περισσότερα »
Bio-assisted potentiometric multisensor system for purity evaluation of recombinant protein A
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Edita Voitechovič, Anton Korepanov, Dmitry Kirsanov, Igor Jahatspanian, Andrey Legin Recombinant proteins became essential components of drug manufacturing. Quality control of such proteins is routine task, which usually requires a lot of time, expensive reagents, specialized equipment and highly educated personnel. In this study we propose a new concept for protein purity evaluation that is based on application of bio-assisted potentiometric multisensor system. The model object for analysis was recombinan... περισσότερα »
Comparison of the solid-phase extraction efficiency of a bounded and an included cyclodextrin-silica microporous composite for polycyclic aromatic hydrocarbons determination in water samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Adela Mauri-Aucejo, Pedro Amorós, Alaina Moragues, Carmen Guillem, Carolina Belenguer-Sapiña Solid-phase extraction is one of the most important techniques for sample purification and concentration. A wide variety of solid phases have been used for sample preparation over time. In this work, the efficiency of a new kind of solid-phase extraction adsorbent, which is a microporous material made from modified cyclodextrin bounded to a silica network, is evaluated through an analytical method which combines so... περισσότερα »
Ultra-trace level speciated isotope dilution measurement of Cr(VI) using ion chromatography tandem mass spectrometry in environmental waters
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Stefanie Mädler, Aaron Todd, H.M. "Skip" Kingston, Matt Pamuku, Fengrong Sun, Cindy Tat, Robert J. Tooley, Teresa A. Switzer, Vasile I. Furdui The reliable analysis of highly toxic hexavalent chromium, Cr(VI), at ultra-trace levels remains challenging, given its easy conversion to non-toxic trivalent chromium. This work demonstrates a novel analytical method to quantify Cr(VI) at low ngL−1 concentration levels in environmental water samples by using speciated isotope dilution (SID) analysis and double-spi... περισσότερα »
A single use electrochemical sensor based on biomimetic nanoceria for the detection of wine antioxidants
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Veronica Andrei, Erica Sharpe, Alina Vasilescu, Silvana Andreescu We report the development and characterization of a disposable single use electrochemical sensor based on the oxidase-like activity of nanoceria particles for the detection of phenolic antioxidants. The use of nanoceria in the sensor design enables oxidation of phenolic compounds, particularly those with ortho-dihydroxybenzene functionality, to their corresponding quinones at the surface of a screen printed carbon electrode. Detection is car... περισσότερα »
A case study of SMART attributes: a qualitative assessment of generalizability, retention rate, and trial quality
Personalizing medical care is becoming increasingly popular, particularly mental health care. There is growing interest in formalizing medical decision making based on evolving patient symptoms in an evidence-... from #Medicine via ola Kala on Inoreader http://ift.tt/1sacKGv via IFTTT
Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial
Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked... from #Medicine via ola Kala on Inoreader http://ift.tt/1YsUAdr via IFTTT
Determination of phytate in high molecular weight, charged organic matrices by two-dimensional size exclusion-ion chromatography
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Kyle R. Elkin, Rosanne Slingsby, Ray B. Bryant A two-dimensional chromatography method for analyzing phytate or other ionic targets in matrices containing high molecular weight, charged organic species is described. Prior to quantification by anion exchange chromatography, the sample matrix was prepared by size exclusion chromatography, which removed the majority of the matrix. Quantification of phytate on the AS11-HC was sensitive (0.25µM, 0.17mg/l) and reproducible (4.6% RSD) allowing this method to prov... περισσότερα »
Rapid estimation of readily leachable triazine residues in soils using automatic kinetic bioaccessibility assays followed by on-line sorptive clean-up as a front-end to liquid chromatography
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Ana C.F. Vida, David J. Cocovi-Solberg, Elias A.G. Zagatto, Manuel Miró An automatic batchwise bioaccessibility test was proposed for on-line monitoring of readily mobile pools of ametryn and atrazine residues in agricultural soils with different physicochemical properties. A 0.01molL−1 CaCl2 solution mimicking rainwater percolation through the soil profiles was used for the herbicide extractions. The extract aliquots were successively sampled at regular time intervals in order to investigate the extracti... περισσότερα »
New optical paper sensor for in situ measurement of hydrogen sulphide in waters and atmospheres
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): J. Pla-Tolós, Y. Moliner-Martínez, J. Verdú-Andrés, J. Casanova-Chafer, C. Molins-Legua, P. Campíns-Falcó A novel and low-cost colorimetric sensor for the determination of hydrogen sulphide in environmental samples has been developed. This sensor is based on the immobilization of the reagent N,N-Dimethyl-p-phenylenediamine and FeCl3 in paper support, in which the H2S is adsorbed in order to give rise to the formation of methylene blue as reaction product.The sensor has been applied to determine H2S in wate... περισσότερα »
Bio-assisted potentiometric multisensor system for purity evaluation of recombinant protein A
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Edita Voitechovič, Anton Korepanov, Dmitry Kirsanov, Igor Jahatspanian, Andrey Legin Recombinant proteins became essential components of drug manufacturing. Quality control of such proteins is routine task, which usually requires a lot of time, expensive reagents, specialized equipment and highly educated personnel. In this study we propose a new concept for protein purity evaluation that is based on application of bio-assisted potentiometric multisensor system. The model object for analysis was recombinan... περισσότερα »
Comparison of the solid-phase extraction efficiency of a bounded and an included cyclodextrin-silica microporous composite for polycyclic aromatic hydrocarbons determination in water samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Adela Mauri-Aucejo, Pedro Amorós, Alaina Moragues, Carmen Guillem, Carolina Belenguer-Sapiña Solid-phase extraction is one of the most important techniques for sample purification and concentration. A wide variety of solid phases have been used for sample preparation over time. In this work, the efficiency of a new kind of solid-phase extraction adsorbent, which is a microporous material made from modified cyclodextrin bounded to a silica network, is evaluated through an analytical method which combines so... περισσότερα »
Ultra-trace level speciated isotope dilution measurement of Cr(VI) using ion chromatography tandem mass spectrometry in environmental waters
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Stefanie Mädler, Aaron Todd, H.M. "Skip" Kingston, Matt Pamuku, Fengrong Sun, Cindy Tat, Robert J. Tooley, Teresa A. Switzer, Vasile I. Furdui The reliable analysis of highly toxic hexavalent chromium, Cr(VI), at ultra-trace levels remains challenging, given its easy conversion to non-toxic trivalent chromium. This work demonstrates a novel analytical method to quantify Cr(VI) at low ngL−1 concentration levels in environmental water samples by using speciated isotope dilution (SID) analysis and double-spi... περισσότερα »
One Author Replies
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Re: "Invited Commentary: How Big Is That Interaction (In My Community)--And in Which Direction?"
[image: ser-logo_final_small.jpg] from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1qlbbnW via IFTTT
Associations Between Vitamin D Level and Hospitalizations With and Without an Infection in a National Cohort of Medicare Beneficiaries
Research has implicated low 25-hydroxyvitamin D (25(OH)D) level as a risk factor for infection; however, results have not been consistent. To further determine the nature of this relationship, we conducted a cohort study using Medicare beneficiaries participating in the 2001–2002 and 2003–2004 cycles of the National Health and Nutrition Examination Survey with data individually linked to hospital records from the Centers for Medicare and Medicaid Services. The primary exposure was a 25(OH)D level of <15 ng/mL versus ≥15 ng/mL. The outcomes were a hospitalization with or without an ... περισσότερα »
Contents Page
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Primary Low Level of High-Density Lipoprotein Cholesterol and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis
Prior studies observing associations between low levels of high-density lipoprotein (HDL) cholesterol and cardiovascular disease (CVD) have often been conducted among persons with metabolic or other lipid abnormalities. In this study, we investigated the association between primary low HDL cholesterol and coronary heart disease (CHD), CVD, and all-cause death after adjustment for confounders in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants who were free of clinical CVD were recruited from 6 US research centers from 2000 to 2002 and followed for a median duration o... περισσότερα »
Comparison of Calipers for Matching on the Disease Risk Score
Previous studies have compared calipers for propensity score (PS) matching, but none have considered calipers for matching on the disease risk score (DRS). We used Medicare claims data to perform 3 cohort studies of medication initiators: a study of raloxifene versus alendronate in 1-year nonvertebral fracture risk, a study of cyclooxygenase 2 inhibitors versus nonselective nonsteroidal antiinflammatory medications in 6-month gastrointestinal bleeding, and a study of simvastatin + ezetimibe versus simvastatin alone in 6-month cardiovascular outcomes. The study periods for each coh... περισσότερα »
Mediation of Racial and Ethnic Disparities in Estrogen/Progesterone Receptor-Negative Breast Cancer by Socioeconomic Position and Reproductive Factors
Hispanic and non-Hispanic black breast cancer patients are more likely than non-Hispanic white patients to be diagnosed with breast cancer that is negative for estrogen and progesterone receptors (ER/PR-negative). This disparity might be transmitted through socioeconomic and reproductive factors. Data on 746 recently diagnosed breast cancer patients (300 non-Hispanic white, 303 non-Hispanic black, 143 Hispanic) were obtained from the population-based Breast Cancer Care in Chicago Study (Chicago, Illinois, 2005–2008). Income, educational level, and census tract measures of concentr... περισσότερα »
Association of Hemoglobin Concentration With Total and Cause-Specific Mortality in a Cohort of Postmenopausal Women
Anemia and low and high levels of hemoglobin have been associated with increased mortality and morbidity. However, most studies have measured hemoglobin at only 1 time point, and few studies have considered possible reverse causation. We used data from the Women's Health Initiative, in which baseline hemoglobin was measured in 160,081 postmenopausal women and year 3 hemoglobin was measured in 75,658 participants, to examine the associations of hemoglobin concentration with total mortality, coronary heart disease mortality, and cancer mortality. Women were enrolled from 1993 to 199... περισσότερα »
Editorial Board
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Statins and Risk of Bleeding: An Analysis to Evaluate Possible Bias Due to Prevalent Users and Healthy User Aspects
Statins are said to protect against a wide range of diseases. We studied to what extent potential bias influences the results of studies on beneficial side effects of statins. We selected 8,188 atrial fibrillation patients who started treatment with anticoagulants at the Leiden Anticoagulation Clinic in the Netherlands between 2003 and 2009 and experienced 1,683 minor and 451 major bleeds during 18,105 person-years of follow-up. Statins were associated with a risk reduction of 9% for bleeds (hazard ratio = 0.91, 95% confidence interval: 0.82, 1.00). Additionally, analyses were stra... περισσότερα »
Performance of Disease Risk Score Matching in Nested Case-Control Studies: A Simulation Study
In a case-control study, matching on a disease risk score (DRS), which includes many confounders, should theoretically result in greater precision than matching on only a few confounders; however, this has not been investigated. We simulated 1,000 hypothetical cohorts with a binary exposure, a time-to-event outcome, and 13 covariates. Each cohort comprised 2 subcohorts of 10,000 patients each: a historical subcohort and a concurrent subcohort. DRS were estimated in the historical subcohorts and applied to the concurrent subcohorts. Nested case-control studies were conducted in the... περισσότερα »
Association Between High Ambient Temperature and Risk of Stillbirth in California
Recent studies have linked elevated apparent temperatures with adverse birth outcomes, such as preterm delivery, but other birth outcomes have not been well studied. We examined 8,510 fetal deaths (≥20 weeks' gestation) to estimate their association with mean apparent temperature, a combination of temperature and humidity, during the warm season in California (May–October) from 1999 to 2009. Mothers whose residential zip codes were within 10 km of a meteorological monitor were included. Meteorological data were provided by the California Irrigation Management Information System, t... περισσότερα »
Can Community Social Cohesion Prevent Posttraumatic Stress Disorder in the Aftermath of a Disaster? A Natural Experiment From the 2011 Tohoku Earthquake and Tsunami
In the aftermath of a disaster, the risk of posttraumatic stress disorder (PTSD) is high. We sought to examine whether the predisaster level of community social cohesion was associated with a lower risk of PTSD after the earthquake and tsunami in Tohoku, Japan, on March 11, 2011. The baseline for our natural experiment was established in a survey of older community-dwelling adults who lived 80 kilometers west of the epicenter 7 months before the earthquake and tsunami. A follow-up survey was conducted approximately 2.5 years after the disaster. We used a spatial Durbin model to ex... περισσότερα »
Oligoantiemesis or Inadequate Prescription of Antiemetics in the Emergency Department: A Local and National Perspective
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 14 May 2016 Source:The Journal of Emergency Medicine Author(s): Adam J. Singer, Greg Garra, Henry C. Thode BackgroundNausea and vomiting are common, but prevalence of antiemetic use in ED patients is unknown.ObjectivesWe determined the use of antiemetics in emergency department (ED) patients presenting with nausea and vomiting (NV).MethodsWe conducted a retrospective […]
A single use electrochemical sensor based on biomimetic nanoceria for the detection of wine antioxidants
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Veronica Andrei, Erica Sharpe, Alina Vasilescu, Silvana Andreescu We report the development and characterization of a disposable single use electrochemical sensor based on the oxidase-like activity of nanoceria particles for the detection of phenolic antioxidants. The use of nanoceria in the sensor design enables oxidation of phenolic compounds, particularly those with ortho-dihydroxybenzene functionality, to their corresponding quinones at the surface of a screen printed carbon electrode. Detection is car... περισσότερα »
Application of a nanostructured platform and imprinted sol-gel film for determination of chlorogenic acid in food samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Carla M. Ribeiro, Eliane M. Miguel, Jonadab dos S. Silva, Cristian B. da Silva, Marília O.F. Goulart, Lauro T. Kubota, Fabiano B. Gonzaga, Wilney J.R. Santos, Phabyanno R. Lima Chlorogenic acid (CGA) is a polyphenol derivative that widely exists in higher plants like fruits, vegetables, black teas, and some traditional Chinese medicines. In this work, we have proposed a sensitive and selective electrochemical sensor for detection of CGA. The sensor was based on a glassy carbon electrode (GCE) modified with... περισσότερα »
Polydimethylsiloxane/metal-organic frameworks coated stir bar sorptive extraction coupled to gas chromatography-flame photometric detection for the determination of organophosphorus pesticides in environmental water samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Zuowei Xiao, Man He, Beibei Chen, Bin Hu In this work, the metal-organic frameworks (MOFs), MIL-101-Cr-NH2 was synthesized via a direct hydrothermal method, and a polydimethylsiloxane (PDMS)/MIL-101-Cr-NH2 coated stir bar was prepared by sol-gel technique. Good reproducibility was obtained for the preparation of PDMS/MIL-101-Cr-NH2 coated stir bar with the relative standard deviations (RSDs) ranging from 3.7 to 5.2% (n=7) in one batch, and from 5.4 to 9.2% (n=7) among different batches. With the high surfa... περισσότερα »
Application of a nanostructured platform and imprinted sol-gel film for determination of chlorogenic acid in food samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Carla M. Ribeiro, Eliane M. Miguel, Jonadab dos S. Silva, Cristian B. da Silva, Marília O.F. Goulart, Lauro T. Kubota, Fabiano B. Gonzaga, Wilney J.R. Santos, Phabyanno R. Lima Chlorogenic acid (CGA) is a polyphenol derivative that widely exists in higher plants like fruits, vegetables, black teas, and some traditional Chinese medicines. In this work, we have proposed a sensitive and selective electrochemical sensor for detection of CGA. The sensor was based on a glassy carbon electrode (GCE) modified with... περισσότερα »
Polydimethylsiloxane/metal-organic frameworks coated stir bar sorptive extraction coupled to gas chromatography-flame photometric detection for the determination of organophosphorus pesticides in environmental water samples
Publication date: 15 August 2016 *Source:*Talanta, Volumes 156–157 Author(s): Zuowei Xiao, Man He, Beibei Chen, Bin Hu In this work, the metal-organic frameworks (MOFs), MIL-101-Cr-NH2 was synthesized via a direct hydrothermal method, and a polydimethylsiloxane (PDMS)/MIL-101-Cr-NH2 coated stir bar was prepared by sol-gel technique. Good reproducibility was obtained for the preparation of PDMS/MIL-101-Cr-NH2 coated stir bar with the relative standard deviations (RSDs) ranging from 3.7 to 5.2% (n=7) in one batch, and from 5.4 to 9.2% (n=7) among different batches. With the high surfa... περισσότερα »
The Case of the Indiscriminate Waveform
[image: 2-9101505-20b971d4-6b81-47cb-abb6-1faa01] From the very start of our Residency training, Emergency Medicine Physicians are tasked with committing to memory the correctable causes of PEA arrest. It is expected any intern worth their salt should be able to recite the H’s & T’s proselytized by the AHA as far back as 1995 (1). And yet, it quickly becomes […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJBMg via IFTTT
The Case of the Man Made of Straw
[image: tumblr_o3txuuL3iu1tveh6co1_500.jpg?resiz] So often when interpreting the medical literature, success is determined by how you define it. Such is the case with a recent article on the management of pain due to ureteral colic. Published in the Lancet in 2016, Pathan et al examined the efficacy of IM diclofenax, IV acetaminophen, or IV morphine in treating the […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJAaX via IFTTT
The Case of the Perfect Imperfection
[image: 875p.jpg?resize=400%2C397] The Enemy of Good is Perfect The interpretation of literature is not dissimilar from the interpretation of the Rorschach tests. To one person the data appears to be a freshly hatched butterfly full of hope and promise. While to another it is a discomforting stain resulting from the splatter of improperly handled bodily excrement. What you […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJwIm via IFTTT
A Case of Shadows Part II
[image: x-ray-machine-e1458966782373.jpg?resize=] I think we all can agree that the subtleties of the thoracic cavity go far beyond the diagnostic capabilities of our standard two-view chest x-ray. We have robust data that demonstrates the superb diagnostic prowess of bedside ultrasound (US) when compared to the mediocrity of plain films (1, 2,3,4). And yet more information is not […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJBf7 via IFTTT
The Case of the Pragmatic Wound
[image: gplate3-e1458506239746.jpg?resize=1105%2] The clinical milieu of the Emergency Department is far from straightforward. The cognitive grime in which we function is rarely conducive to the pristine distinctions drawn by Evidence-Based Medicine (EBM). As such we are often asked to make dichotomous decisions based off a single study, using answers to questions we never intended on asking. Until […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJHmQ via IFTTT
The Case of the Anatomic Injury
[image: 595-PB3-R1.jpg?resize=483%2C277] It is not uncommon for the standard of care to be dictated by those who speak the loudest rather than a representative sample of best medical practice. This is certainly the case with the inclusion of whole-body CT scans in the initial management of patients presenting to the Emergency Department with traumatic complaints. Known […] EMCrit by Rory Spiegel. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23RJGzi via IFTTT
Fwd: Laboratory Medicine, Year 2016, Issue 03 -New Issue Alert.
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM [image: 1PHav7d] New Issue TOC Alert *Dear Valued Customer*, [image: 1SchPFA] We are pleased to deliver your requested table of contents alert for *Laboratory Medicine*. Year *2016* Issue *03* is now available on CAOD. *In this issue:* Improving laboratory diagnosis ability of infectious diseases in children using multiple assays (运用多种方法提升儿童感染性疾病的实验诊断能力) XU Jin ...... page:155-158 Research progress of cytomegalovirus envelope glycoprotein B,H and N and their genotypes (巨细胞病毒包膜糖蛋白 B、H、N 及其基因型的研究进展) DONG Niuniu, ,XU Jin... περισσότερα »
Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?
It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin ant... from thyroid via a.lsfakia on Inoreader http://ift.tt/27nEGHf via IFTTT
Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?
Abstract Background It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin antibody (TgAb) levels increase the likelihood that a thyroid nodule is malignant. Methods A retrospective review of 586 patients who underwent thyroidectomy was conducted. Demographic data, TgAb levels, and final histopathology were recorded. Patients were divided into two groups: TgAb positive (defined as TgAb ≥ 30 IU/ml) and TgAb low/negative (defined as T... περισσότερα »
China Cancer, Year 2016, Issue 05 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for China Cancer. Year 2016 Issue 05 is now available on CAOD. In this issue: Clinical and Epidemiological Features of Pancreatic Neuroendocrine Neoplasm in China,2001～2010 (2001~2010年中国胰腺神经内分泌肿瘤的临床流行病学特征分析) ZHANG Yu-qing, MA […]
Journal of Modern Clinical Medicine, Year 2016, Issue 02 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Modern Clinical Medicine. Year 2016 Issue 02 is now available on CAOD. In this issue: you mei tuo zuo ding yong yu yu fang bing bo […]
Neural Injury and Functional Reconstruction, Year 2016, Issue 01 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Neural Injury and Functional Reconstruction. Year 2016 Issue 01 is now available on CAOD. In this issue: Comparison of Biological Characters between Different Sources of Endothelial Cells (不同来源内皮细胞生物学性状的比较) […]
World Notes on Antibiotics, Year 2016, Issue 02 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for World Notes on Antibiotics. Year 2016 Issue 02 is now available on CAOD. In this issue: xin xi dong tai (信息动态) …… page:49-51,96 Advances about the Geldanamycin Derivative […]
Journal of Oral and Maxillofacial Surgery, Year 2016, Issue 01 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Oral and Maxillofacial Surgery. Year 2016 Issue 01 is now available on CAOD. In this issue: Calcium Phosphates as Bone Substitute for Dental Implant Surgery (口腔种植中磷酸钙类骨替代材料的应用) […]
Journal of Clinical Stomatology, Year 2016, Issue 01 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Clinical Stomatology. Year 2016 Issue 01 is now available on CAOD. In this issue: you xia zuo jian ya shuang gen shuang gen guan 1 li […]
Shiyong Pharmacy and Clinical Remedies, Year 2016, Issue 01 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Shiyong Pharmacy and Clinical Remedies. Year 2016 Issue 01 is now available on CAOD. In this issue: Effect of ginsenoside Rh2 on endothelial progenitor cells number of high […]
Qilu Pharmaceutical Affairs, Year 2016, Issue 03 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Qilu Pharmaceutical Affairs. Year 2016 Issue 03 is now available on CAOD. In this issue: Chemical constituents from the stems of Clausena lansium (黄皮茎枝的化学成分研究) LIU Jie, ,LI Chuangjun, […]
Shanghai Journal of Biomedical Engineering, Year 2016, Issue 01 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Shanghai Journal of Biomedical Engineering. Year 2016 Issue 01 is now available on CAOD. In this issue: Extracting Technology and Structure Characterization of Type II Collagen from Squid […]
Laboratory Medicine, Year 2016, Issue 03 -New Issue Alert.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Laboratory Medicine. Year 2016 Issue 03 is now available on CAOD. In this issue: Improving laboratory diagnosis ability of infectious diseases in children using multiple assays (运用多种方法提升儿童感染性疾病的实验诊断能力) XU […]
Fwd: Journal of Modern Clinical Medicine, Year 2016, Issue 02 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Modern Clinical Medicine*. Year *2016* Issue *02* is now available on CAOD. *In this issue:* you mei tuo zuo ding yong yu yu fang bing bo fen zhu she tong de yan jiu jin zhan (右美托咪定用于预防丙泊酚注射痛的研究进展) ZHANG Bo, ,LIU Danyan ...... page:83-85,89 pa jin sen bing yao wu zhi liao yan jiu jin zhan (帕金森病药物治疗研究进展) LIN Qing, ,LUO Yongjie ...... page:86-89 jing duan yu xiong shang duan shi guan ai de wai ke... περισσότερα »
Fwd: Neural Injury and Functional Reconstruction, Year 2016, Issue 01 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Neural Injury and Functional Reconstruction*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* Comparison of Biological Characters between Different Sources of Endothelial Cells (不同来源内皮细胞生物学性状的比较) XU Hui-fang, ,WANG Jun-li, ,QIU Xin, ,WAN Xiao-lin, ,CHEN Guo-hua ...... page:1-4 xin xi dong tai (信息动态) ...... page:4,30,55 Effect of Acid-sensing Ion Channels Blocker on Acid Induced Migraine... περισσότερα »
Fwd: World Notes on Antibiotics, Year 2016, Issue 02 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *World Notes on Antibiotics*. Year *2016* Issue *02* is now available on CAOD. *In this issue:* xin xi dong tai (信息动态) ...... page:49-51,96 Advances about the Geldanamycin Derivative 17-AAG (微生物来源的Hsp90抑制剂——抗癌格尔德霉素衍生物17-AAG的研究进展) Gu Jue-fen ...... page:52-60,72 Research Prosess of Aurora Kinases and Its Inhibitors (Aurora激酶及其抑制剂研究进展) Ling Jing, ,Zhang Lei, ,Li Ze-min, ,Yao Qi-zheng ...... page:61-67,80 Pro... περισσότερα »
Fwd: Journal of Oral and Maxillofacial Surgery, Year 2016, Issue 01 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Oral and Maxillofacial Surgery*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* Calcium Phosphates as Bone Substitute for Dental Implant Surgery (口腔种植中磷酸钙类骨替代材料的应用) CHEN Zhuofan, ,LIU Quan, ,MATINLINNA Jp ...... page:1-12 Concentrated Growth Factor and 1, 25 Dihydroxy Vitamin D3 Enhance Proliferation and Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem cells (浓缩... περισσότερα »
Fwd: Journal of Clinical Stomatology, Year 2016, Issue 01 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Stomatology*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* you xia zuo jian ya shuang gen shuang gen guan 1 li (右下颌尖牙双根双根管1例) WANG Jiaocui, ,ZHU Yajun ...... page:2 The effects of circadian rhythm gene PER1 on the expression of osteogenesis related genes in vitro (昼夜节律基因PER1对成骨相关基因表达影响的体外研究) LI Weikang, ,QIN Xu, ,GUAN Zuo, ,LIU Meng, ,LIAO Shuteng, ,LU Haibo, ,SHI ... περισσότερα »
Fwd: Shiyong Pharmacy and Clinical Remedies, Year 2016, Issue 01 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Shiyong Pharmacy and Clinical Remedies*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* Effect of ginsenoside Rh2 on endothelial progenitor cells number of high fat diet rats with myocardial ischemia-reperfusion (人参皂苷Rh2对高脂膳食大鼠心肌缺血再灌注时内皮祖细胞的影响) ZHOU Qin, ,WANG Xi, ,WANG Long ...... page:1-6 Effects of naringin on cerebral vasospasm and apoptosis after subarachnoid hemorrhage in rats (... περισσότερα »
Fwd: Qilu Pharmaceutical Affairs, Year 2016, Issue 03 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Qilu Pharmaceutical Affairs*. Year *2016* Issue *03* is now available on CAOD. *In this issue:* Chemical constituents from the stems of Clausena lansium (黄皮茎枝的化学成分研究) LIU Jie, ,LI Chuangjun, ,YANG Jingzhi, ,MA Jie, ,ZHANG Dongming ...... page:125-128,184 Study on mechanism of Tibetan Gentianopsispaludosa(Hook.f.)Ma.extraction(GPE) inducing colon cancer cells apoptosis by NF -κB signaling pathway (藏药湿生扁蕾提取... περισσότερα »
Fwd: Shanghai Journal of Biomedical Engineering, Year 2016, Issue 01 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Shanghai Journal of Biomedical Engineering*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* Extracting Technology and Structure Characterization of Type II Collagen from Squid Cartilage (鱿鱼软骨II型胶原蛋白提取方法及结构分析) GUO Xiuyu, ,HE Lan, ,WEI Xiaojuan, ,WANG Nanping ...... page:1-5 Influence of Operation Details on the Results of Antibacterial Experiment (抗菌实验操作细节对测试效果的影响) ZHANG Qian, ,CHEN Xia... περισσότερα »
Fwd: Laboratory Medicine, Year 2016, Issue 03 -New Issue Alert.
Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 1 ώρα
From: order@email.oriprobe.com Date: May 15, 2016 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Laboratory Medicine*. Year *2016* Issue *03* is now available on CAOD. *In this issue:* Improving laboratory diagnosis ability of infectious diseases in children using multiple assays (运用多种方法提升儿童感染性疾病的实验诊断能力) XU Jin ...... page:155-158 Research progress of cytomegalovirus envelope glycoprotein B,H and N and their genotypes (巨细胞病毒包膜糖蛋白 B、H、N 及其基因型的研究进展) DONG Niuniu, ,XU Jin ...... page:159-162 Detection of... περισσότερα »
Treatment outcome of ion beam therapy in eight patients with head and neck cancers.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--production.springer.de-OnlineReso] Related Articles *Treatment outcome of ion beam therapy in eight patients with head and neck cancers.* Eur Arch Otorhinolaryngol. 2016 May 11; Authors: Ohkubo JI, Hohchi N, Takeuchi S, Ikezaki S, Kise Y, Koizumi H, Suzuki H Abstract Ion beam therapy has enabled us to treat formerly untreatable malignant tumors. The aim of the present study was to investigate the long-term follow-up course of patients with head and neck cancers who received ion beam therapy. The subjects were 8 patients (3 men and 5 women aged 43-78 years) with he... περισσότερα »
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.* J Oral Pathol Med. 2016 May 9; Authors: Daniel FI, Alves SR, Vieira DS, Biz MT, Daniel IW, Modolo F Abstract BACKGROUND: Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this st... περισσότερα »
Simultaneous gingival squamous cell carcinoma in an oral lichen planus patient.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Simultaneous gingival squamous cell carcinoma in an oral lichen planus patient.* Quintessence Int. 2016 May 12; Authors: Vora K, Bhattacharyya I, Kashtwari D, Nair M, Katz J Abstract OBJECTIVE: To describe a case of bilateral simultaneous squamous cell carcinoma of the gingiva affecting the mandible in a lichen planus patient and discuss the pertinent literature. METHOD AND MATERIALS: We present a case of a 50-year-old woman with a history of oral lichen planus who was diagnosed with a primary and a second primary squamous cell carcinoma originating from the mandibular gingiva. A... περισσότερα »
Adenosquamous Carcinoma of the Head and Neck: A Case-Control Study with Conventional Squamous Cell Carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Adenosquamous Carcinoma of the Head and Neck: A Case-Control Study with Conventional Squamous Cell Carcinoma.* Head Neck Pathol. 2016 May 12; Authors: Mehrad M, Trinkaus K, Lewis JS Abstract Adenosquamous carcinoma (AdSC) is considered a rare variant of squamous cell carcinoma (SCC) which is considered to be more clinically aggressive. Data is very limited with very little case matched data on outcomes in the literature. It is also unknown whether the quantity of the adenocarcinoma component affects outcomes. A retrospective case-control study with 23 cases of AdSC and 1137 SCC ... περισσότερα »
Genetic analysis of radiation-specific biomarkers in sinonasal squamous cell carcinomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract The aim of this study was to investigate the differences in the gene expression profiles of radiation-sensitive (RS) and radiation-resistant (RR) sinonasal squamous cell carcinoma (SNSCC) and to identify prognostic markers for the radiation reaction of SNSCC. We first examined the differentially expressed genes (DEGs) in RS and RR SNSCC tissues by analyzing clinical samples with GeneChip Human Transcriptome Array 2.0 (HTA 2.0).To understand the functional significance of the molecular changes, we examined the DEGs with Gene Ontology (GO) and pathway analyses to identify t... περισσότερα »
Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Aim The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC). Materials and Methods The study included 60 patients *(*15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Statistical analysis of the data was done using Tuckey's test, ANOVA and independent sam... περισσότερα »
Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Objective The objective of this study was to investigate serum and salivary levels of chemerin and MMP-9 as early diagnostic biomarkers for patients with oral premalignant lesions (OPMLs) and oral squamous cell carcinoma (OSCC). Methods This study included 45 individuals; 15 healthy control, 15 patients with OPMLs, and 15 patients with early stage OSCC. Chemerin and MMP-9 were determined in serum and saliva samples utilizing enzyme-linked immunosorbent assays. Results Serum and salivary levels of chemerin and MMP-9 in patients with OSCC were significantly higher than OP... περισσότερα »
De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Conditions*: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Oropharyngeal Neoplasms *Interventions*: Radiation: Intensity Modulated Radiotherapy (IMRT); Drug: Cisplatin (or alternative); Procedure: Assessment for surgical evaluation *Sponsor*: UNC Lineberger Comprehensive Cancer Center *Recruiting* - verified May 2016 from squamous cell carcinoma via ok on Inoreader http://ift.tt/251AsX8 via IFTTT
Efficacy Study of Pembrolizumab in Relapsed, Locally Recurrent Squamous Cell Cancer of the Head and Neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Pembrolizumab; Other: Placebo *Sponsors*: Ezra Cohen; Merck Sharp & Dohme Corp. *Not yet recruiting* - verified May 2016 from squamous cell carcinoma via ok on Inoreader http://ift.tt/1sdv4P1 via IFTTT
Efficacy Study of Pembrolizumab in Relapsed, Locally Recurrent Squamous Cell Cancer of the Head and Neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Pembrolizumab; Other: Placebo *Sponsors*: Ezra Cohen; Merck Sharp & Dohme Corp. *Not yet recruiting* - verified May 2016 from squamous cell carcinoma via ok on Inoreader http://ift.tt/1sdv4P1 via IFTTT
Level IIB Neck Dissection in Oral Squamous Cell Carcinoma: Science or Myth?.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Selective neck dissection enables us to reduce the morbidity of neck dissection while maintaining the same oncological results, mainly in clinically negative neck N0. The most common morbidity associated with selective neck dissection is spinal accessory nerve dysfunction and related shoulder disability, which are encountered during dissection of level IIB. The aim of authors' study is to evaluate the incidence of sublevel IIB lymphatic metastasis in clinically N0 oral squamous cell carcinoma (OSCC) patients. The study group comprised 48 men (68%) and 22 women (32%). The median numb... περισσότερα »
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