Atypical and malignant granular cell tumors
Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study: Abstract BackgroundMalignant granular cell tumors (MGCTs) are extremely rare neoplasms with only a limited number of studies published to date. The aim of this study is to elucidate the clinicopathological characteristics and prognostic factors of MGCTs. MethodsThis is a multi-institutional retrospective study of MGCTs with a central pathological review. A total of 18 cases were retrieved. Specimens were blindly reviewed by two pathologists based on the diagnostic criter... περισσότερα »
Incorporation of next-generation sequencing into routine clinical care to direct treatment of head and neck squamous cell carcinoma
Incorporation of next-generation sequencing into routine clinical care to direct treatment of head and neck squamous cell carcinoma: Purpose: The clinical impact of next-generation sequencing (NGS) in patients with head and neck squamous cell carcinoma (HNSCC) has not been described. We aimed to evaluate the clinical impact of NGS in the routine care of patients with HNSCC and to correlate genomic alterations with clinical outcomes. Experimental Design: Single-center study examining targeted NGS platform used to sequence tumor DNA obtained from 213 HNSCC patients evaluated in outpa...περισσότερα »
Angiogenesis inhibitor; +21 new citations
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2016/01/15 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/QGMHBq(((Angiogenesis%20inhibitor)%20AND%20%222016%2F01%2F14%2006.59%22%5BMHDA%5D%3A%222016%2F01%2F1... περισσότερα »
A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM).
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM).* PLoS One. 2015;10(2):e0108917 Authors: Gerber M, Fischer A, Jagannathan V, Drögemüller M, Drögemüller C, Schmidt MJ, Bernardino F, Manz E, Matiasek K, Rentmeister K, Leeb T Abstract Dandy-Walker-like malformation (DWLM) is the result of aberrant brain development and mainly characterized by cerebellar hypoplasia. DWLM affected dogs display a non-progressive cerebe... περισσότερα »
Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease.* J Alzheimers Dis. 2015;45(2):509-20 Authors: Meeker KD, Meabon JS, Cook DG Abstract The glutamate transporter GLT-1 (also called EAAT2 in humans) plays a critical role in regulating extracellular glutamate levels in the central nervous system (CNS). In Alzheimer's disease (AD), EAAT2 loss is associated with neuropathology and cognitive impairment. In keeping with this, we have reported ... περισσότερα »
Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.
*Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.* Int J Audiol. 2016 Jan 14;:1-10 Authors: McCullagh MC, Banerjee T, Cohen MA, Yang JJ Abstract OBJECTIVE: The purpose of this study was to compare the effectiveness of three interventions designed to promote hearing protector device (HPD) use. DESIGN: Randomized controlled trial. STUDY SAMPLE: Farm operators (n = 491) were randomly assigned to one of five intervention groups: (1) interactive web-based information with mailed assortment of HPDs; (2) Interactive web-based info... περισσότερα »
Trends in colorectal cancer in the elderly in Denmark, 1980-2012.
*Trends in colorectal cancer in the elderly in Denmark, 1980-2012.* Acta Oncol. 2016 Jan 14;:1-11 Authors: Brændegaard Winther S, Baatrup G, Pfeiffer P, Qvortrup C, Academy of Geriatric Cancer Research (AgeCare) Abstract Background Colorectal cancer (CRC) is a disease of the older population. The current demographic ageing leads to more elderly patients and is expected to further increase the number of patients with CRC. The objective of the present paper is to outline incidence, mortality and prevalence from 1980 to 2012 and survival data from 1968 to 2012 in Danish CRC patients...περισσότερα »
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
*Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.* Eur J Cancer. 2016 Jan 5;53:171-180 Authors: van Maldegem AM, Bovée JV, Peterse EF, Hogendoorn PC, Gelderblom H Abstract BACKGROUND: In the last three decades the outcome for patients with localised Ewing sarcoma (ES) has improved significantly since the introduction of multimodality primary treatment. However, for patients with (extra-) pulmonary metastatic and/or non-resectable relapsed disease the outcome remains poor and new treatment options are urgently ne...περισσότερα »
Expression analysis of BECN1 in acute myeloid leukemia: association with distinct cytogenetic and molecular abnormalities.
*Expression analysis of BECN1 in acute myeloid leukemia: association with distinct cytogenetic and molecular abnormalities.* Int J Lab Hematol. 2016 Jan 13; Authors: Zare-Abdollahi D, Safari S, Movafagh A, Ghadiani M, Tabarraee M, Riazi-Isfahani S, Gorji S, Keyvan L, Gachkar L Abstract INTRODUCTION: In acute myeloid leukemia (AML), it has been shown that AML-derived cells often remain sensitive to autophagy-inducing stimuli, leading to the idea that harnessing the autophagy can be pertinent to AML cytotoxic therapy. Despite this promising notion, to date, there is no comprehensi...περισσότερα »
The Future of Surgical Oncology: Image-Guided Cancer Surgery.
*The Future of Surgical Oncology: Image-Guided Cancer Surgery.* JAMA Surg. 2016 Jan 13;:1-2 Authors: Singhal S PMID: 26765107 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1OSYiL6 via IFTTT
Immune-related adverse events with immune checkpoint blockade: a comprehensive review.
*Immune-related adverse events with immune checkpoint blockade: a comprehensive review.* Eur J Cancer. 2016 Jan 5;54:139-148 Authors: Michot JM, Bigenwald C, Champiat S, Collins M, Carbonnel F, Postel-Vinay S, Berdelou A, Varga A, Bahleda R, Hollebecque A, Massard C, Fuerea A, Ribrag V, Gazzah A, Armand JP, Amellal N, Angevin E, Noel N, Boutros C, Mateus C, Robert C, Soria JC, Marabelle A, Lambotte O Abstract Cancer immunotherapy is coming of age; it has prompted a paradigm shift in oncology, in which therapeutic agents are used to target immune cells rather than cancer cells. T... περισσότερα »
Servier's pipeline in oncology: moving from research to patients.
*Servier's pipeline in oncology: moving from research to patients.* Future Oncol. 2016 Jan 14; Authors: Therasse P, Abastado JP PMID: 26764971 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1OSYiuC via IFTTT
Looking back to inform the future: Lesson learned from survivors of childhood cancer.
*Looking back to inform the future: Lesson learned from survivors of childhood cancer.* Cancer. 2016 Jan 14; Authors: Armenian SH, Bhatia S PMID: 26764891 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1OSYfz4 via IFTTT
An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.
*An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.* Cell Death Dis. 2016;6:e2047 Authors: Pinazza M, Borga C, Agnusdei V, Minuzzo S, Fossati G, Paganin M, Michielotto B, De Paoli A, Basso G, Amadori A, Te Kronnie G, Indraccolo S Abstract Despite some success with certain hematological malignancies and in contrast with the strong pro-apoptotic effects measured in vitro, the overall response rate of acute lymphoblastic leukemia (ALL) to histone deacetylase inhibitors (HDACis... περισσότερα »
The Validity of the Distress Thermometer in Greek Colon Cancer Patients.
*The Validity of the Distress Thermometer in Greek Colon Cancer Patients.* Acta Chir Belg. 2015 Nov-Dec;115(6):387-92 Authors: Antoniadis D, Lavrentiadis G, Papadopoulos VN, Ierodiakonou I, Garyfallos G Abstract BACKGROUND: Although screening for distress is a crucial part of psycho-social care for cancer patients, there has not been a validation study for this purpose in Greece. The purpose of this study was to evaluate for the first time the psychometric properties of the Greek translation of the Distress Thermometer (DT) and Problem List (PL) in Greek colorectal cancer patien... περισσότερα »
Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma.
*Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma.* J Invest Dermatol. 2016 Jan;136(1):245-54 Authors: Jayawardana K, Schramm SJ, Tembe V, Mueller S, Thompson JF, Scolyer RA, Mann GJ, Yang J Abstract In metastatic melanoma, it is vital to identify and validate biomarkers of prognosis. Previous studies have systematically evaluated protein biomarkers or mRNA-based expression signatures. No such analyses have been applied to microRNA (miRNA)-based prognostic signatures. As a first step, we identified two prognostic mi... περισσότερα »
Radiotherapeutic Management of Non-Small Cell Lung Cancer in the Minimal Resource Setting.
*Radiotherapeutic Management of Non-Small Cell Lung Cancer in the Minimal Resource Setting.* J Thorac Oncol. 2016 Jan;11(1):21-9 Authors: Rodin D, Grover S, Xu MJ, Hanna TP, Olson R, Schreiner LJ, Munshi A, Mornex F, Palma D, Gaspar LE, International Association for the Study of Lung Cancer Advanced Radiation Technology Committee Abstract Lung cancer is the most common cancer worldwide and the fifth most common cause of death globally. Its incidence continues to increase, especially within low- and middle-income countries (LMICs), which have limited capacity to address the growi... περισσότερα »
Guidelines for the management of cancer and thrombosis - Special aspects in women.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Guidelines for the management of cancer and thrombosis - Special aspects in women.* Thromb Res. 2015 Feb;135 Suppl 1:S16-22 Authors: Bauersachs RM Abstract BACKGROUND: Occurrence of venous thromboembolism (VTE) in patients with cancer is associated with unfavorable prognosis, and VTE treatment is less effective and more complicated in cancer patients. Several women specific aspects related to the underlying cancer type and VTE management need to be considered. METHODS: Guidelines on VTE prevention and treatment i... περισσότερα »
Totally Implantable Venous Access Devices
Totally Implantable Venous Access Devices in Children Requiring Long-Term Chemotherapy: Analysis of Outcome in 122 Children from a Single Institution.: AbstractChildren with malignancy require venous access that is reliable, safe and compliant on a long-term basis. There is little data available on utilization of totally implantable venous access devices (TIVAD) for long term chemotherapy in children in an Indian setting [1]. We report our long-term follow-up results of utilization of totally implantable venous access devices for long-term chemotherapy in children. This was a retr...περισσότερα »
Cancer-Related Constituents of Strawberry Jam as Compared with Fresh Fruit
Cancers, Vol. 8, Pages 16: Cancer-Related Constituents of Strawberry Jam as Compared with Fresh Fruit: The health awareness recently shown by consumers has led to a demand for health beneficial products. In particular, researchers are currently focusing their studies on the search for foods for cancer prevention activity. In the present work, we study comparatively the effect of two different processing methods on the contents of phenolic compounds (i.e., ellagic acid, myricetin, quercetin and kaempferol) with antioxidant and antitumor properties in strawberry jams. In turn, the res...περισσότερα »
Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.
*Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.* Int J Audiol. 2016 Jan 14;:1-10 Authors: McCullagh MC, Banerjee T, Cohen MA, Yang JJ Abstract OBJECTIVE: The purpose of this study was to compare the effectiveness of three interventions designed to promote hearing protector device (HPD) use. DESIGN: Randomized controlled trial. STUDY SAMPLE: Farm operators (n = 491) were randomly assigned to one of five intervention groups: (1) interactive web-based information with mailed assortment of HPDs; (2) Interactive web-based info... περισσότερα »
Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.
*Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.* Int J Audiol. 2016 Jan 14;:1-8 Authors: Bouserhal RE, Macdonald EN, Falk TH, Voix J Abstract OBJECTIVE: Speech production in noise with varying talker-to-listener distance has been well studied for the open ear condition. However, occluding the ear canal can affect the auditory feedback and cause deviations from the models presented for the open-ear condition. Communication is a main concern for people wearing... περισσότερα »
Atypia of undetermined significance in thyroid FNA
Young investigator challenge: Atypia of undetermined significance in thyroid FNA: Standardized terminology without standardized management—a closer look at repeat FNA and quality measures: BACKGROUND The Bethesda system (TBS) for the reporting of thyroid cytopathology established the category of atypia of undetermined significance (AUS) with a 7% target rate and a 5% to 15% implied malignancy risk. Recent literature has reported a broad range of AUS rates, subsequent malignancy rates, and discrepant results from repeat fine-needle aspiration (FNA) versus surgical follow-up. Therefo... περισσότερα »
Silvestrol induces early autophagy and apoptosis in human melanoma cells
Silvestrol induces early autophagy and apoptosis in human melanoma cells: Abstract BackgroundSilvestrol is a cyclopenta[*b*]benzofuran that was isolated from the fruits and twigs of *Aglaia foveolata*, a plant indigenous to Borneo in Southeast Asia. The purpose of the current study was to determine if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultured human cancer cells derived from solid tumors. MethodsIn vitro cell viability, flow cytometry, fluorescence microscopy, qPCR and immunoblot was used to study the mechanism of action of ... περισσότερα »
Screening of intracerebral hemorrhage associated allele combinations at different loci using a novel association analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Liping Gai, Cui Sun, Weijian Yu, Hui Liu BackgroundGenetic research has progressed along with scientific and technological developments. However, it is difficult to identify frequency differences in the allele combination at cross-loci.ObjectiveThe purpose of this study was to examine the relationship between the presence […]
Characterization of type I and II procollagen α1chain in Amur sturgeon (Acipenser schrenckii) and comparison of their gene expression
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Xi Zhang, Noriko Azuma, Seishi Hagihara, Shinji Adachi, Kazuhiro Ura, Yasuaki Takagi To characterize type I and II collagen in the Amur sturgeon at the molecular level, mRNAs encoding the proα chain of both types of collagen were cloned and sequenced. Full sequences of […]
Cardioprotective effect of miRNA-22 on hypoxia/reoxygenation induced cardiomyocyte injury in neonatal rats
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Jian Yang, Lihua Chen, Jiawang Ding, Jing Zhang, Zhixing Fan, Chaojun Yang, Qinqin Yu, Jun Yang MicroRNAs (miRNAs) are implicated in the regulation of pathological and physiological processes in myocardial ischemia/reperfusion (MI/R). Recent studies have revealed that miR-22 might provide a potential cardioprotective effect […]
Long noncoding RNA expression profiles of hypoxic pulmonary hypertension rat model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Xiaohua Wang, Chao Yan, Xiaoling Xu, Liangliang Dong, Hua Su, Yanjie Hu, Ruifeng Zhang, Kejing Ying ObjectiveRecently, long noncoding RNAs(lncRNAs) have been proved to be playing crucial roles in various biological processes, yet their role in hypoxic pulmonary hypertension (HPH) remains unclear. The aim […]
Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Manal L. Louka, Maggie M. Ramzy IntroductionThe intense basic research on the molecular and cellular mechanisms of liver fibrosis regression intends to translate these findings into new therapies targeting such pathways in human liver disease. Fibrosis regression is rapidly initiated in mouse models of […]
Editorial Board
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4gCCX via IFTTT
Genetic characterization and evolutionary analysis of Newcastle disease virus isolated from domestic duck in South Korea
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Satish Gaikwad, Ji-Ye Kim, Hyun-Jeong Lee, Suk Chan Jung, Kang-Seuk Choi Domestic ducks are considered a potential reservoir of Newcastle disease virus. In the study, a Newcastle disease virus (NDV) isolated from a domestic duck during surveillance in South Korea was characterized. The complete […]
Molecular characterization and expression patterns of emerin (EMD) gene in skeletal muscle between Meishan and Large White pigs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Yan Wang, Xia Xiao, Linjie Wang The emerin protein is a nuclear membrane protein and has important functions in muscle development, regeneration, and cell signal transduction. However, knowledge regarding emerin in the domestic animal is limited. In this study, we cloned and characterized the […]
Transcriptome analysis of the Tan sheep testes: Differential expression of antioxidant enzyme-related genes and proteins in response to dietary vitamin E supplementation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Chenchen Xu, Zhaoyun Zuo, Kun Liu, Huina Jia, Yuwei Zhang, Hailing Luo Gene-chip technology was employed to study the effect of dietary vitamin E on gene expression in sheep testes based on our previous research. Thirty-five male Tan sheep (20–30days after weaning) with similar […]
Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 10 δευτερόλεπτα
Publication date: 15 March 2016 Source:Gene, Volume 579, Issue 1 Author(s): Haifeng Zhu, Xiaoqin Li, Xiaomei Zhang, Deyu Chen, Dan Li, Jin Ren, Hangang Gu, Yongqian Shu, Deqiang Wang BackgroundEpigenetic alterations of DNA mismatch repair (MMR) genes are associated with risk of gastric cancer (GC) by causing microsatellite instability (MSI). Less understood is the association […]
Elevation of IL-9 in Extreme Patch Test Reactions Suggests It Is an Inflammatory Mediator in Allergic Contact Dermatitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Elevation of IL-9 in Extreme Patch Test Reactions Suggests It Is an Inflammatory Mediator in Allergic Contact Dermatitis from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TZZRHa via IFTTT
Benzalkonium Chloride: A Known Irritant and Novel Allergen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Benzalkonium Chloride: A Known Irritant and Novel Allergen: Background: Benzalkonium chloride (BAK), a detergent and preservative found in health care and household products, is an established irritant, yet BAK is seldom considered to cause allergic contact dermatitis. We have, however, observed positive patch test reactions more often than is typically reported. From 2001 through 2005 […]
Glove Use and Glove Education in Workers with Hand Dermatitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Glove Use and Glove Education in Workers with Hand Dermatitis: Background: Occupational skin diseases are common. The occurrence of occupational skin diseases represents a failure of primary prevention strategies that may include the use of personal protective equipment, most commonly gloves. Objective: The objective of this study was to describe current glove use and education […]
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Quantify Ingredient Usage
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Quantify Ingredient Usage: Background: The usage prevalence of ingredients in topical products is important to dermatologists and industry. Objective: To determine the prevalence of methylisothiazolinone (MI) in various types of consumer products Methods: The Contact Allergy Management Program (CAMP) database was mapped and […]
Sensitization to Formaldehyde
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Sensitization to Formaldehyde in Northeastern Italy, 1996 to 2012: Background: Formaldehyde is a widely used organic compound, used in several applications (hard thermoset resins, adhesives, disinfectants, tissue fixatives, etc), in its free form or released by formaldehyde releaser products. Its use is under control due to its toxic, carcinogenic, and allergenic properties. Objective: The aim […]
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Determine Relative Prevalence of Contact Allergens
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Determine Relative Prevalence of Contact Allergens: Background: Data on the prevalence of contact allergy in North America are currently reported by groups of academic contact allergy specialists at select academic centers. Sampling of data from numerous centers across North America, including practices performing […]
Photo-contact Allergy to Octocrylene in a Ketoprofen-sensitized Subject
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Almost Missed It! Photo-contact Allergy to Octocrylene in a Ketoprofen-sensitized Subject from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TZZPzc via IFTTT
Instrument-related Skin Disorders in Musicians
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Instrument-related Skin Disorders in Musicians: Background: Among artists, musicians may suffer from occupational skin problems; notwithstanding, these conditions have been rarely reviewed. The characteristics of individual performer and the type of instrument will determine the kind of disease. Moreover, the hours that the musician spent to advance artistic skill may influence the severity. Objective: The […]
Atopic dermatitis (eczema)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Patient Perspectives: Atopic dermatitis (eczema): With the now-universal access to web-based information, there is a need to provide clear, concise, and accurate medical information to patients and their families informing them about their medical conditions. Most practioners rely on electronic health records, and the ability to share information with patients in the form of “patients […]
Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα
Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research Requirement for vitamin D supplementation in patients using photoprotection: variations invitamin D levels and bone formation markers J Bogaczewicz, E Karczmarewicz… – International journal …, 2015 – Wiley Online Library … of oral supplementation in many populations is often overlooked by healthcare … […]
Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours—a single institution pilot study
Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours—a single institution pilot study: AbstractRecently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate ... περισσότερα »
Caveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1
Caveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1: AbstractEsophageal squamous cell carcinoma (ESCC) is the most common cancer in China, and multidrug resistance (MDR) remains one of the biggest problems in ESCC chemotherapy. In this study, we aimed to investigate the mechanism of Caveolin-1, an integral membrane protein, on regulating ESCC MDR. First, immunohistochemistry was used to check the protein expression of Caveolin-1, MDR-related protein of P-glycoprotein (P-gp), and multidrug resistance protein 1 (MR... περισσότερα »
Recurrent or progressive malignancies
Pharmacokinetics, metabolism, and excretion of 14 C-labeled belinostat in patients with recurrent or progressive malignancies: Summary*Background* Belinostat, a potent pan-inhibitor of histone deacetylase (HDAC) enzymes, is approved in the United States (US) for relapsed/refractory peripheral T-cell lymphoma. In nonclinical studies, bile and feces were identified as the predominant elimination routes (50–70 %), with renal excretion accounting for ~30–50 %. A Phase 1 human mass balance study was conducted to identify species-dependent variations in belinostat metabolism and eliminat...περισσότερα »
Adjuvant radiotherapy in Masaoka stage II-IV thymomas
Survival impact of adjuvant radiotherapy in Masaoka stage II-IV thymomas – A systematic review and meta-analysis via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 14 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Yu Jin Lim, Eunji Kim, Hak Jae Kim, Hong-Gyun Wu, Jinchun Yan, Qin Liu, Shilpen Patel PurposeDue to the lack of randomized evidence, no conclusion has been made concerning the role of postoperative radiotherapy (PORT) in thymomas. This systematic review and meta-analysis evaluated the... περισσότερα »
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver: AbstractThe present study was executed to study the effect of chronic arsenic exposure on generation of mitochondrial oxidative stress and biogenesis in rat liver. Chronic sodium arsenite treatment (25 ppm for 12 weeks) decreased mitochondrial complexes activity in rat liver. There was a decrease in mitochondrial superoxide dismutase *(*MnSOD) activity in arsenic-treated rats that might be responsible for increased protein and lipid oxidation as observed in our study. T... περισσότερα »
Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells into Cancer Stem Cells Depends on HPV status
Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells into Cancer Stem Cells Depends on HPV status via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 14 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Erina Vlashi, Allen M. Chen, Sabrina Boyrie, Garrett Yu, Andrea Nguyen, Philip A. Brower, Clayton B. Hess, Frank Pajonk PurposeHuman papilloma virus (HPV), HPV-16, is one of the most important prognostic factors for patients with head and neck squamous cell carcinomas (HNSCCs). HPV-posi... περισσότερα »
Engineering IgA for Cancer Immunotherapy
Engineering IgA for Cancer Immunotherapy: Antibodies of IgA isotype effectively engage myeloid effector cells for cancer immunotherapy. Here, we describe preclinical studies with an Fc engineered IgA2m(1) antibody containing the variable regions of the EGFR antibody cetuximab. Compared with wild-type IgA2m(1), the engineered molecule lacked two N-glycosylation sites (N166 and N337), two free cysteines (C311 and C472), and contained a stabilized heavy and light chain linkage (P221R mutation). This novel molecule displayed improved production rates and biochemical properties compared ...περισσότερα »
KIR and HLA in Skin Cancer
KIR and HLA in Skin Cancer: Natural killer (NK)–cell phenotype is partially mediated through binding of killer-cell immunoglobulin-like receptors (KIR) with HLA class I ligands. The KIR gene family is highly polymorphic and not well captured by standard genome-wide association study approaches. Here, we tested the hypothesis that variations in KIR gene content combined with HLA class I ligand status is associated with keratinocyte skin cancers using a population-based study of basal cell carcinoma (BCC) and squamous cell carcinomas (SCC). We conducted an interaction analysis of KIR g... περισσότερα »
Melanoma Phenotype-Dependent Mast Cell Recruitment
Melanoma Phenotype-Dependent Mast Cell Recruitment: Human melanomas exhibit considerable genetic, pathologic, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing to melanoma pathogenesis, but their ability to recapitulate the phenotypic variability of human disease and the complex interactions with the immune system have not been addressed. Here, we report the unexpected finding that immune cell–poor pigmented and immune cell–rich amelanotic melanomas developed simultaneously in Cdk4R24C-mutant m... περισσότερα »
PTENLOF/BRAFMUT Melanoma
BRAF/PI3K{beta}/IGF1R Inhibitor Synergy in PTENLOF/BRAFMUT Melanoma: The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAFMUT) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most likely because these pathways constitute a codependent signaling network. Concomitant PTEN loss of function (PTENLOF) occurs in approximately 40% of BRAFMUT melanomas. In this study, we sought to identify the nodes of the PTEN/PI3K pathway that would be amenable to combine... περισσότερα »
MEK1-induced skin carcinogenesis
Macrophage infiltration and alternative activation during wound healing promote MEK1-induced skin carcinogenesis.: Macrophages are essential for the progression and maintenance of many cancers, but their role during the earliest stages of tumor formation is unclear. To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal cells results in chronic inflammation (InvEE mice). Upon wounding, the number of epidermal and dermal monocytes and macrophages increased ...περισσότερα »
Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL-6 modulation
Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL-6 modulation: Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely understood. In this study, we used a mouse model of radiation-induced salivary hypofunction to investigate the outcomes of DNA damage in the head and neck region. We demonstrate that the loss of salivary function was closely accompanied by...περισσότερα »
Metaplasia induced by H. pylori infection
Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses: Chronic infection with the bacterial H. pylori is a major cause of gastric and duodenal ulcer disease, gastric mucosal atrophy and cancer. H. pylori-induced expression of the intestinal epithelial-specific transcription factor Cdx2 contributes to intestinal metaplasia (IM), a precursor event to gastric cancer. Given a role for the bacterial pattern recognition molecule NOD1 in the innate immune response to bacterial infection, we investigat... περισσότερα »
Updates in Therapy for Advanced Melanoma
Cancers, Vol. 8, Pages 17: Updates in Therapy for Advanced Melanoma: Cutaneous melanoma is one of the most aggressive forms of skin cancer, and is correlated with a large proportion of skin cancer-related deaths. Therapy for cutaneous melanoma has advanced greatly through careful identification of therapeutic targets and the development of novel immunotherapeutic approaches. The identification of BRAF as well as other driver mutations, have allowed for a specialized approach to treatment. In addition, immune checkpoint inhibition has dramatically changed the treatment landscape over...περισσότερα »
Elevation of IL-9 in Extreme Patch Test Reactions Suggests It Is an Inflammatory Mediator in Allergic Contact Dermatitis
Elevation of IL-9 in Extreme Patch Test Reactions Suggests It Is an Inflammatory Mediator in Allergic Contact Dermatitis
Benzalkonium Chloride: A Known Irritant and Novel Allergen
Benzalkonium Chloride: A Known Irritant and Novel Allergen: [image: image] Background: Benzalkonium chloride (BAK), a detergent and preservative found in health care and household products, is an established irritant, yet BAK is seldom considered to cause allergic contact dermatitis. We have, however, observed positive patch test reactions more often than is typically reported. From 2001 through 2005 and 2006 through 2010, BAK was among the top 10 most frequent allergens in our standard series. Objective: The aim of this study was to review the Mayo Clinic experience from 2000 to 20...περισσότερα »
Glove Use and Glove Education in Workers with Hand Dermatitis
Glove Use and Glove Education in Workers with Hand Dermatitis: [image: image] Background: Occupational skin diseases are common. The occurrence of occupational skin diseases represents a failure of primary prevention strategies that may include the use of personal protective equipment, most commonly gloves. Objective: The objective of this study was to describe current glove use and education practices related to gloves in workers being assessed for possible work-related hand dermatitis. Methods: Participants included consecutive patients being assessed for possible work-related han...περισσότερα »
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Quantify Ingredient Usage
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Quantify Ingredient Usage: [image: image] Background: The usage prevalence of ingredients in topical products is important to dermatologists and industry. Objective: To determine the prevalence of methylisothiazolinone (MI) in various types of consumer products Methods: The Contact Allergy Management Program (CAMP) database was mapped and sorted in spreadsheet format to determine the prevalence of MI in various types of consumer products. Results: Methylisothiazolinone was found in 13.2% ... περισσότερα »
Sensitization to Formaldehyde
Sensitization to Formaldehyde in Northeastern Italy, 1996 to 2012: [image: image]Background: Formaldehyde is a widely used organic compound, used in several applications (hard thermoset resins, adhesives, disinfectants, tissue fixatives, etc), in its free form or released by formaldehyde releaser products. Its use is under control due to its toxic, carcinogenic, and allergenic properties. Objective: The aim of this study was to investigate the frequency of formaldehyde sensitization, time trend, and correlation to occupations. Methods: This study is a cross-sectional study on a popula... περισσότερα »
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Determine Relative Prevalence of Contact Allergens
American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Determine Relative Prevalence of Contact Allergens: Background: Data on the prevalence of contact allergy in North America are currently reported by groups of academic contact allergy specialists at select academic centers. Sampling of data from numerous centers across North America, including practices performing more limited patch testing, would provide a broader perspective of contact allergen prevalence in North America. The American Contact Dermatitis Society Contact Allergy Managem... περισσότερα »
Photo-contact Allergy to Octocrylene in a Ketoprofen-sensitized Subject
Almost Missed It! Photo-contact Allergy to Octocrylene in a Ketoprofen-sensitized Subject
Instrument-related Skin Disorders in Musicians
Instrument-related Skin Disorders in Musicians: Background: Among artists, musicians may suffer from occupational skin problems; notwithstanding, these conditions have been rarely reviewed. The characteristics of individual performer and the type of instrument will determine the kind of disease. Moreover, the hours that the musician spent to advance artistic skill may influence the severity. Objective: The frequency and risk factors of instrument-related skin disorders in musicians from southern Italy were analyzed. Methods: An observational study was conducted in 628 musicians. A q... περισσότερα »
Atopic dermatitis (eczema)
Patient Perspectives: Atopic dermatitis (eczema): With the now-universal access to web-based information, there is a need to provide clear, concise, and accurate medical information to patients and their families informing them about their medical conditions. Most practioners rely on electronic health records, and the ability to share information with patients in the form of “patients handouts” is easier than ever. Pediatric dermatologists, dermatologists, pediatricians, family practitioners, and internists diagnose a number of conditions in common and the SPD has initiated work on... περισσότερα »
Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research
Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research Requirement for *vitamin D *supplementation in patients using photoprotection: variations in*vitamin D *levels and bone formation markers J Bogaczewicz, E Karczmarewicz… - International journal …, 2015 - Wiley Online Library *...* of oral supplementation in many populations is often *overlooked* by healthcare *...* physiological secondary hyperparathyroidism, *vitamin* *D* deficiency, inadequate osteoblast *function*, and decreased *...* was to investigate whether the skin pigmentation, as a *...περισσότερα »
Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children
Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children: Abstract Background The current treatment of keloids includes surgery, intralesional steroids, and radiotherapy, among others. Radiotherapy is not recommended in children due to its effects on growing tissues. Our aim was to study intralesional triamcinilone therapy of keloids in children and analyze the impact of body location, age of the lesion, and etiology of the keloid on clinical response. Methods We conducted a prospective clinical trial with patients 1 to 14 years of age evaluated for kelo... περισσότερα »
Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area
Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area: Abstract Cutaneous rhabdomyomatous mesenchymal hamartoma (RMH) is a rare benign tumor composed of two or more types of mesenchymal-derived cells. RMHs are generally sporadic and independent, but they can be associated with congenital abnormalities. We report a subcutaneous case of RMH in the sternoclavicular area with two recurrences after complete surgical excision. The course is variable and can range from spontaneous resolution to repeated recurrences.
Arsenic Trioxide and Itraconazole for Metastatic Basal Cell Carcinoma
Arsenic Trioxide and Itraconazole for Metastatic Basal Cell Carcinoma: This case series reports the effects of treatment with arsenic trioxide and itraconazole on GLI messenger RNA expression in 5 patients with metastatic basal cell carcinoma who experienced disease progression despite treatment with Smoothened inhibitors.
Pembrolizumab for Unresectable Cutaneous Squamous Cell Carcinoma
Pembrolizumab for Unresectable Cutaneous Squamous Cell Carcinoma: [image: s_dlo150032f1.png] This case report describes the successful treatment of unresectable cutaneous squamous cell carcinoma with pembrolizumab, a programmed cell death protein 1 inhibitor.
Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.
*Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20154026 Authors: Shetty VB, Fournier PA, Davey RJ, Retterath AJ, Paramalingam N, Roby HC, Cooper MN, Davis EA, Jones TW Abstract CONTEXT: No recommendations exist to inform the carbohydrate amount required to prevent hypoglycaemia associated with exercise of different intensities in individuals with type 1 diabetes (T1D). OBJECTIVE: The relationship between exercise intensity and carbohydrate requirements to maintain stable eu...περισσότερα »
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.
*Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153785 Authors: Hong N, Yoon HJ, Lee YH, Kim HR, Lee BW, Rhee Y, Kang ES, Cha BS, Lee HC Abstract CONTEXT: Recent animal studies showed that tumor-derived parathyroid hormone-related peptide (PTHrP) induced cancer cachexia by fat browning with increased energy expenditure; however clinical evidence from human data is insufficient. OBJECTIVE: We investigated whether serum PTHrP levels independently predicts weight loss (WL) ...περισσότερα »
Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.
*Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153303 Authors: Moreno-Navarrete JM, Blasco G, Xifra G, Karczewska-Kupczewska M, Stefanowicz M, Matulewicz N, Puig J, Ortega F, Ricart W, Straczkowski M, Fernández-Real JM Abstract CONTEXT: Different genetic and imaging iron markers are known to be increased in the liver, adipose tissue and brain of obese subjects. OBJECTIVE: We aimed to investigate these markers in human skeletal muscle. Design, setting, patients and outcome measures... περισσότερα »
Efficacy of buccal fat pad in the surgical management of oral submucous fibrosis: a prospective study
Efficacy of buccal fat pad in the surgical management of oral submucous fibrosis: a prospective study: Abstract PurposeVarious surgical treatment modalities have been advocated in the surgical management of oral submucous fibrosis with variable results. This prospective study evaluates the efficacy of buccal fat pad in the surgical treatment of oral submucous fibrosis. Patients and MethodIn the present study, 20 patients were treated for oral submucous fibrosis with interincisal mouth opening less than 16 mm. Surgical procedure included fibrotomy, all third molar extractions, a...περισσότερα »
Patch Testing for Contact Allergy
Patch Testing for Contact Allergy: This medical record review of patients undergoing patch testing with combined methylchloroisothiazolinone-methylisothiazolinone and methylisothiazolinone measures the prevalence of contact allergy.
Eosinophilic Fasciitis
Epidemiology and Treatment of Eosinophilic Fasciitis: [image: dld150028.pdf.gif] This study reports that misdiagnoses, unnecessary procedures, and undertreatment were common among patients with eosinophilic fasciitis, while combination therapy with corticosteroids and methotrexate resulted in higher rates of complete response.
Eruptive Keratoacanthomas Associated With Leflunomide
Eruptive Keratoacanthomas Associated With Leflunomide: [image: s_dlo150027f1.png] This case report describes the occurrence of leflunomide-associated eruptive keratoacanthomas.
Melanoma Screening
Cost-effective Melanoma Screening: [image: ded150011.pdf.gif] Despite recent advances in immunotherapy and molecularly targeted therapies for advanced melanoma, early detection remains the most effective means of preventing death from melanoma. In 2015, an estimated 73 000 new cases of invasive melanoma will be diagnosed in the United States, and approximately 9900 people will die of the disease. To date, early-detection efforts for melanoma in the United States have relied on self-detection and opportunistic screening. The recent experience in Germany suggests a role for organ... περισσότερα »
Skin Cancer Awareness
Google Search Volume Index Peaks and Skin Cancer Awareness Month: [image: dlr150008.pdf.gif] *In Reply* We thank Dr Kantor for his interest in our study. While we believe the American Academy of Dermatology’s May skin cancer awareness initiative is vital in improving outreach, its effect on population interest is less clear. Although the awareness initiative may provide a slight increase in Search Volume Index (SVI) at peak times, it is not clear it primarily drives searches.
Facial Papules in a Patient With Long-Term Cystinosis
Facial Papules in a Patient With Long-Term Cystinosis: [image: s_dlo150030f1.png] This case report describes the occurrence of facial papules in a patient with long-term cystinosis.
News and Events
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Volume 91, Issue 12, December 2015, pages 973-973<br>10.3109/09553002.2015.1133876<br> from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ldz5PJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Relationship between thin-film bond strength as measured by a scratch test, and indentation hardness for bonding agents
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Dental Materials Author(s): Shusuke Kusakabe, H. Ralph Rawls, Masato Hotta ObjectivesTo evaluate thin-film bond strength between a bonding agent and human dentin, using a scratch test, and the characteristics and accuracy of measurement.MethodsOne-step bonding agents (BeautiBond; Bond Force; Adper Easy Bond; Clearfil tri-S Bond) and two-step bonding agents […]
Performance of a cylindrical diode array for use in a 1.5 T MR-linac
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
At the UMC Utrecht, a linear accelerator with integrated magnetic resonance imaging (MRI) has been developed, the MR-linac. Patient-specific quality assurance (QA) of treatment plans for MRI-based image guided radiotherapy requires QA equipment compatible with this 1.5 T magnetic field. The purpose of this study was to examine the performance characteristics of the ArcCHECK-MR in […]
Assessing the quality of proton PBS treatment delivery using machine log files: comprehensive analysis of clinical treatments delivered at PSI Gantry 2
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Pencil beam scanning (PBS) proton therapy requires the delivery of many thousand proton beams, each modulated for position, energy and monitor units, to provide a highly conformal patient treatment. The quality of the treatment is dependent on the delivery accuracy of each beam and at each fraction. In this work we describe the use of […]
Does the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
OBJECTIVE: Inflammation may play an important role in the etiopathology of febrile convulsions (FC). IL-1β is an important mediator of inflammation and fever is also important information of FCs. It is suggested that there may be a relationship between polymorphisms of IL-1β and FC. The aim of the present study is to investigate the polymorphic […]
Study on the expression of VEGF and HIF-1α in infarct area of rats with AMI
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
OBJECTIVE: To investigate the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α) in infarct area of rats with acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 36 healthy male Wistar rats weighing 180 g-220 g were included in our study and were randomly divided into two groups of 6 […]
The MTHFR C677T polymorphism is associated with mitral valve rheumatic heart disease
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
OBJECTIVE: Rheumatic heart disease (RHD) is a serious complication of rheumatic fever (RF). Plasma homocysteine (Hcy) levels are increased in RHD patients. MTHFR catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and plays a vital role in Hcy metabolism. We hypothesize that the MTHFR C677T polymorphism is associated with a risk of RHD. PATIENTS AND […]
Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
OBJECTIVE: Previous studies reported that NDRG2 might be a tumor suppressor of prostate cancer. In this study, we investigated the hypoxia-induced expression change of miR-301a/b in prostate cancer cells and explored its regulation on NDRG2 in autophagy and viability of prostate cancer cells. MATERIALS AND METHODS: MiR-301a/b expression in hypoxia and normoxia cultured prostate cancer […]
Viruses, Vol. 8, Pages 19: Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”. These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A was more divergent than CiHHV-6B by examining four genes in 44 European CiHHV-6A/B cardiac/haematology patients. […]
«Orlando Magic» – read the proceedings of the 57th @ASH_hematology meeting in our new conference report: https://t.co/UjG924kidn
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
«Orlando Magic» – read the proceedings of the 57th @ASH_hematology meeting in our new conference report: https://t.co/UjG924kidn from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/687931012081434628 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Rosacea or photodamaged skin? Use of brimonidine gel in differentiating erythema in the two conditions
Rosacea or photodamaged skin? Use of brimonidine gel in differentiating erythema in the two conditions: Abstract In this case report, we detail the response of a 37-year-old Caucasian man with an overlap of erythematotelangiectatic rosacea and telangiectatic photoaging to brimonidine tartrate gel. With the application of brimonidine only on half of his face, skin analysis images, clinician's and patient's assessment showed that there was significant improvement in the erythema. This case has lent insight into how brimonidine can be used to assess the extent of photoaging by elimina... περισσότερα »
Breast Hypoplasia as a Complication of an Untreated Infantile Hemangioma
Breast Hypoplasia as a Complication of an Untreated Infantile Hemangioma: Abstract We report the case of a mixed infantile hemangioma (IH) involving the right breast that resulted in pronounced hypoplasia of the affected breast, which became apparent after breast development at puberty. No treatment had been performed in infancy or childhood. This case demonstrates that the presence of an IH may affect development of the mammary gland bud and that systemic therapy should be considered in an attempt to minimize this adverse sequela.
Lymphomatoid papulosis (LyP) is a cutaneous CD30-positive T-cell lymphoproliferative disorder
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature: Abstract Lymphomatoid papulosis (LyP) is a cutaneous CD30-positive T-cell lymphoproliferative disorder that occurs primarily in adults and presents with crops of papules that become necrotic and spontaneously regress. It is classified according to the histopathologic findings; currently recognized subtypes include A, B, C, D, and E. LyP is uncommon in children. Herein we describe a child with an unusual clinical presentation of LyP type D and review the literature of reported cases in children.
The “Heart Sign”: An Early Indicator of Dose-Dependent Doxycycline-Induced Phototoxicity
The “Heart Sign”: An Early Indicator of Dose-Dependent Doxycycline-Induced Phototoxicity: Abstract Oral doxycycline is an antibiotic commonly used for the treatment of inflammatory acne in adolescents. Dose-dependent phototoxicity, unrelated to dose duration, is a well-known complication of its use. We present three adolescents who developed bilateral phototoxic rashes on the dorsal thenar spaces of their hands while taking doxycycline for their acne. Identification of the “heart sign” rash as a specific doxycycline-related phototoxic reaction should alert clinicians to the need fo... περισσότερα »
Subcutaneous Panniculitis-Like T-Cell Lymphoma with Hemophagocytic Syndrome in a Child
Subcutaneous Panniculitis-Like T-Cell Lymphoma with Hemophagocytic Syndrome in a Child: Abstract Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) characterized by subcutaneous infiltration of pleomorphic T-cells of the α/β phenotype rarely affects children. Development of hemophagocytic syndrome (HPS) leads to a poor prognosis with this otherwise indolent lymphoma. We report a case of SPTCL in a 5-year-old child complicated by HPS treated successfully with combination chemotherapy. We discuss the potential pitfalls in reaching an early diagnosis and challenges in its manageme... περισσότερα »
Pilot testing and validation of an atopic dermatitis screening and evaluation questionnaire
Pilot testing and validation of an atopic dermatitis screening and evaluation questionnaire: Abstract Background Atopic dermatitis (AD) is a major public health concern worldwide. Given its rising prevalence, there is a pressing need to study its epidemiology. To date, no validated, cost-effective, and patient self-administered screening instrument exists that can reliably distinguish AD from other skin conditions. Our aim is to develop an instrument that can validate a self-reported AD diagnosis quickly and with reasonable accuracy in a population at a distance. Methods A one-page... περισσότερα »
Serum osteopontin level and common carotid artery intima-media wall thickness in psoriasis
Serum osteopontin level and common carotid artery intima-media wall thickness in psoriasis: Abstract Background The association between psoriasis and cardiovascular disease is well documented, but the underlying mechanisms remain unknown. The relationship between osteopontin and psoriasis has been studied. High serum levels of osteopontin are reported in psoriasis, with increased cardiovascular risk factors in these patients. Objectives We evaluate the extent of subclinical atherosclerosis by measuring the mean intima–media wall thickness (MIMT) of the common carotid artery (CCA) in... περισσότερα »
Ecological momentary assessment of the relationship between headache pain intensity and pain interference in women with migraine and obesity
Ecological momentary assessment of the relationship between headache pain intensity and pain interference in women with migraine and obesity: Background While pain intensity during migraine headache attacks is known to be a determinant of interference with daily activities, no study has evaluated: (a) the pain intensity-interference association in real-time on a per-headache basis, (b) multiple interference domains, and (c) factors that modify the association. Methods Participants were 116 women with overweight/obesity and migraine seeking behavioral treatment to lose weight and d... περισσότερα »
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation: Introduction Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. The FHM3 subtype is caused by mutations in *SCN1A*, which is also the most frequent epilepsy gene encoding the voltage-gated Na+ channel NaV1.1. The aim of this study was to explore the clinical, genetic and pathogenetic features of a pure FHM3 family. Methods A three-generation family was enrolled in this study for genetic testing and assessment of clinical features. Whole cell patch-clamp was performed ... περισσότερα »
Provocation tests with glyceryl trinitrate (GTN) and calcitonin gene-related peptide (CGRP)
Laboratory tests of headache disorders - dawn of a new era?: Context The classification of headache disorders has improved over the years, but further work is needed to develop and improve headache diagnosis within headache subtypes. The present review is a call for action to implement laboratory tests in the classification and management of primary and some secondary headaches. Background In this narrative review we present and discuss published tests that might be useful in phenotyping and/or diagnosis of long-lasting headache disorders such as migraine, tension-type headache, tr...περισσότερα »
Laboratory tests of headache disorders - dawn of a new era?
Laboratory tests of headache disorders - dawn of a new era?: Context The classification of headache disorders has improved over the years, but further work is needed to develop and improve headache diagnosis within headache subtypes. The present review is a call for action to implement laboratory tests in the classification and management of primary and some secondary headaches. Background In this narrative review we present and discuss published tests that might be useful in phenotyping and/or diagnosis of long-lasting headache disorders such as migraine, tension-type headache, tr...περισσότερα »
Is palinopsia in migraineurs an enhanced physiological phenomenon?
Is palinopsia in migraineurs an enhanced physiological phenomenon?: Background We report the occurrence of palinopsia in patients with migraine and its correlation with migraine characteristics, triggers and allodynia. Methods This study included 153 consecutive patients with migraine and recorded their clinical details, including allodynia and migraine triggers and characteristics. Palinopsia was evaluated in migraineurs and 101 controls by using a questionnaire and a novel method. Results According to the questionnaire assessment, 9.8% migraineurs had palinopsia. According to t... περισσότερα »
Congenital Bilateral Zygomatico-Maxillo-Mandibular Fusion Associated With Gum Fusion
Congenital Bilateral Zygomatico-Maxillo-Mandibular Fusion Associated With Gum Fusion: [image: image] Abstract: A congenial syngnathia is very rare condition. It can be simple mucosal fusion (synechiae), or complete bony fusion (synostosis) between the maxilla or zygoma and the mandible. Fusion of the ascending ramus of mandible to maxilla and zygoma is less common than fusions of the alveolar ridges of the mandible to the maxilla. Bony syngnathia is either isolated or complex in form. There are 59 cases of congenital bony syngnathia reported in the literature: the first report was ...περισσότερα »
Assessment of Labionasal Structures in Patients With Unilateral Cleft Lip
Assessment of Labionasal Structures in Patients With Unilateral Cleft Lip: [image: image] Introduction: Unilateral cleft lip (UCL) patients have lip and nose deformities that must be addressed during lip repair. Currently, devices to achieve lip and nose improvements have been developed. The most researched presurgical molding device is the nasoalveolar molding (NAM), which has shown favorable results. However, clinical observation shows that unilateral cleft patients, even without molding devices, achieve spontaneous improvements. The aim of this study is to compare morphological ... περισσότερα »
The Efficacy of Continuous Negative Pressure and Irrigation Treatment Inside the Wound by a Closed System in Reconstruction of All Layers of the Cranium Accompanying Infection and Cerebrospinal Fluid Leakage
The Efficacy of Continuous Negative Pressure and Irrigation Treatment Inside the Wound by a Closed System in Reconstruction of All Layers of the Cranium Accompanying Infection and Cerebrospinal Fluid Leakage: [image: image]Abstract: There have been many reports to date with respect to treatments on reconstruction of the cranium without accompanying infections following trauma and tumor resection. The morality is, however, high in patients observed with generation of cranial bone defect of all layers accompanying infection and cerebrospinal fluid leakage, and moreover, there are bare... περισσότερα »
Rhinologic Evaluation and Pretreatment for Patients Undergoing Two-Jaw Surgery Through Nasotracheal Intubation
The Significance of Rhinologic Evaluation and Pretreatment for Patients Undergoing Two-Jaw Surgery Through Nasotracheal Intubation: [image: image]Abstract: The aim of this study is to determine whether rhinologic preoperative evaluation and pretreatments reduce intranasal trauma and decrease postoperative complications, such as nasal obstruction and epistaxis, in patients undergoing 2-jaw surgery with nasotracheal intubation. This study included 360 patients with malocclusion (Class III) who underwent 2-jaw surgery under general anesthesia via nasotracheal intubation in our hospital... περισσότερα »
Palatal Osseous Choristoma
Palatal Osseous Choristoma: [image: image]Abstract: Osseous choristoma of soft tissue in the oral cavity is rare. The choristoma is a tumor-like mass of normal cells in an abnormal location. In this report, a case of osseous choristoma of the palate in a 37-year-old male patient was reported. Approximately 6 × 5 mm pedunculated healthy colored and hard mass was observed in the median palate. The mass was surgically removed. Microscopic examination of the hematoxylin and eosin-stained sections of the mass revealed that a dense lamellar bone nodule was surrounded by fibrous connective...περισσότερα »
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion: Abstract: The correction of cicatricial ectropion often presents a challenge to plastic surgeons because of the difficulty obtaining tissue of similar color and texture and producing minor morbidity to donor sites. The authors present the correction of upper cicatricial ectropion by rotating the orbicularis myocutaneous flap from the same lid. From April 2008 to March 2014, 8 consecutive patients with upper cicatricial ectropion underwent transfer of orbicularis oculi myocutaneous flap. The main outcome measures in... περισσότερα »
Change of Facial Asymmetry in Patients With Congenital Muscular Torticollis After Surgical Release
Change of Facial Asymmetry in Patients With Congenital Muscular Torticollis After Surgical Release: [image: image] Background: A number of studies have shown that facial asymmetry improves in congenital muscular torticollis (CMT) patients after surgical release. This study confirmed the improvement in facial asymmetry, and analyzed factors that affect the change of facial asymmetry in CMT patients after surgical release by using objective and quantitative methods. Methods: Facial asymmetry was analyzed in 60 CMT patients who underwent surgical release before 10 years of age. Horizon... περισσότερα »
Primary Infraorbital Foramen Decompression for the Zygomaticomaxillary Complex Fracture: Is It Essential?
Primary Infraorbital Foramen Decompression for the Zygomaticomaxillary Complex Fracture: Is It Essential?: [image: image]Purpose: The frequency of zygomaticomaxillary fracture is second only to nasal bone fracture. Up to 30% to 80% of zygomaticomaxillary fracture patients complain of sensory disturbance results from infraorbital nerve injury. The objective of this study was to detect what factors are related to infraorbital nerve recovery and specifically to investigate decompression of infraorbital foramen improves sensory recovery. Patients and Methods: A total of 257 patients were... περισσότερα »
Osteogenic Genes in Calvarial Critical-Sized Defects
The Impact of Age Upon Healing: Absolute Quantification of Osteogenic Genes in Calvarial Critical-Sized Defects: [image: image]Background: The current study was performed to elucidate changes in growth factor expression over time in critical-sized calvarial defects in rats from infancy to skeletal maturity. Materials and Methods: Critical-sized parietal defects of 5, 6, and 8 mm were created in postnatal day 6 (P6), postnatal day (P20), and postnatal day (P84) adult rats, respectively. Dura was harvested at 3, 7, or 14 days after surgery, and serial micro–computed tomography imaging ... περισσότερα »
Oral Propranolol With Topical Timolol Maleate Therapy for Mixed Infantile Hemangiomas
Oral Propranolol With Topical Timolol Maleate Therapy for Mixed Infantile Hemangiomas in Oral and Maxillofacial Regions: Purpose: The combination treatment for mix infantile hemangiomas (IHs) using oral propranolol with topical timolol maleate was not well documented in the literature. The aim of this study was to evaluate the therapeutic effects and safety of oral propranolol along with topical timolol maleate or oral propranolol alone for treating mixed IHs in the oral and maxillofacial regions. Methods: Between March 2013 and June 2014, a total of 31 patients with mixed IHs in the... περισσότερα »
Selenium on Ischemia-Reperfusion Injury
The Effect of Selenium on Ischemia-Reperfusion Injury: An Experimental Study on a Transverse Rectus Abdominis Musculocutaneous Flap Model: [image: image]Background: The aim of this study is to investigate effects of selenium and enlighten the possible mechanism of action in a rat transverse musculocutaneous flap model following ischemia-reperfusion injury. Materials and Methods: In this study, an experimental model, which mimicked free tissue transfer, was applied. Twenty-four male Wistar Albino rats were divided into a control group (N = 12), and a selenium treated group (N = 12). A...περισσότερα »
Does the Degree of Septal Deviation Affect Cribriform Plate Dimensions and Middle Turbinate Length?
Does the Degree of Septal Deviation Affect Cribriform Plate Dimensions and Middle Turbinate Length?: [image: image]Objective: To investigate the effect of septal deviation severity on the dimensions of the lateral lamina of the cribriform plate (LLCP), middle turbinate length (MTL), and the angle of the lateral lamella of the cribriform plate (ALLCP). Methods: Paranasal computed tomography (CT) scans of 148 patients with septum deviation (102 males, 46 females; age range 18–63 years) were retrospectively evaluated. The patients were divided into 3 groups according to the measured ang...περισσότερα »
Osseointegrated Prosthetic Auricular Reconstruction in Patients With a Compromised Ipsilateral Temporoparietal Fascial Flap
Clinical Outcomes of Osseointegrated Prosthetic Auricular Reconstruction in Patients With a Compromised Ipsilateral Temporoparietal Fascial Flap: [image: image]Abstract: Patients with major ear deformities and associated compromise of the superficial temporal artery are poor candidates for autogenous ear reconstruction because of a tenuous ipsilateral temporoparietal fascial flap (TPFF). Osseointegrated prosthetic auricular reconstruction (OPAR) is an alternative to contralateral free TPFF microsurgical and autogenous reconstruction, but data on clinical outcomes are limited. The re...περισσότερα »
Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss
Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss: [image: image]Objective: The aim of this study was to investigate the possible effects of routine hematological parameters on the development and prognosis of idiopathic sudden sensorineural hearing loss in patients applying to our clinic. Study design: A retrospective clinical study. Setting: One academic health center from 2008 to 2014. Patients and intervention: One hundred forty patients with sudden hearing loss and 132 healthy controls were included in the pre...περισσότερα »
How Often Does Isolated Sphenoid Sinus Disease Turn Out to be a Neoplasm?
How Often Does Isolated Sphenoid Sinus Disease Turn Out to be a Neoplasm?: [image: image]Abstract: Isolated sphenoid sinus disease (ISSD) describes a wide spectrum of pathologies including inflammatory, vascular, bony dysplastic, and neoplastic diseases. The aim of this study was to assess the frequency with which a neoplastic process was diagnosed in patients of ISSD and patient management strategies. A retrospective analysis was conducted for all ISSD patients who underwent surgery between January 2005 and January 2014 at a tertiary center. The clinical characteristics, radiologic ...περισσότερα »
Obturator Prostheses for Melanotic Neuroectodermal Tumor of Infancy in the Maxilla
Obturator Prostheses for Melanotic Neuroectodermal Tumor of Infancy in the Maxilla: [image: image]Abstract: Melanotic neuroectodermal tumor of infancy frequently affects the maxilla. A communication between the oral and nasal cavities can be created by surgery. The authors rehabilitated a young patient with obturator prostheses to correct feeding. The association of the obturators with orthodontic devices provided proper maxillary growth and eruption of teeth. The outcomes were very satisfactory after a 3-year follow-up, and dental implants are planned.
The Age-Related Development of Maxillary Sinus in Children
The Age-Related Development of Maxillary Sinus in Children: [image: image]Introduction: Paranasal sinuses are complex structures and show individual variation. Providing normative values for paranasal sinus size and their changes related to age could be helpful in evaluating the presence of some diseases related to sinonasal region. The purpose of the current study was to investigate the development of maxillary sinuses and evaluate the volume changes according to age and sex by using stereological and ellipsoidal formula methods after that to compare these approaches with each other... περισσότερα »
The Management for Intracranial Metastatic Neuroendocrine Tumor With Lung Origin
The Management for Intracranial Metastatic Neuroendocrine Tumor With Lung Origin: [image: image]Abstract: Neuroendocrine tumor (NET) is not a common source of brain metastasis and the standatd management of intracranial metastatic NET with lung origin remains unclear as a result of its rarity. We aimed to generalize some applicable protocols from our current 2 cases and relevant literature.
Routine Screening Ultrasound in Children With Cleft Palate and/or Lip: A Single Center Experience
Routine Screening Ultrasound in Children With Cleft Palate and/or Lip: A Single Center Experience: [image: image] Abstract: The aim of this study is to evaluate the incidence of associated congenital anomalies that is picked up by screening ultrasound of the heart, urinary system, and central nervous system (CNS) of children with cleft palate and/or lip deformities in a single regional center. A total of 225 children with cleft deformities were recruited in the study in 2009 to 2013, 91% of them underwent screening echocardiogram and of these, 98% of them were normal findings that ...περισσότερα »
Use of Adipose-Derived Mesenchymal Stem Cells to Accelerate Neovascularization in Interpolation Flaps
Use of Adipose-Derived Mesenchymal Stem Cells to Accelerate Neovascularization in Interpolation Flaps: [image: image] Objective: Interpolation flaps are commonly used in plastic surgery to cover wide and deep defects. The need to, wait for 2 to 3 weeks until the division of the pedicle still, however, poses a serious challenge, not only extending treatment and hospital stay, but also increasing hospital expenses. To solve this problem, we have aimed to use the angiogenic potential of stem cells to selectively accelerate neovascularization with a view to increasing the viability of ... περισσότερα »
Anthropometric Effect of Mucoperiosteal Nostril Floor Reconstruction in Complete Cleft Lip
Anthropometric Effect of Mucoperiosteal Nostril Floor Reconstruction in Complete Cleft Lip: [image: image] Objective: The primary objective of this study was to investigate whether growth impairment in children with cleft lip is caused by reconstructing the nostril floor using lateral nasal and premaxillary mucoperiosteal flaps. The effects on growth and symmetry of tip rhinoplasty at the time of initial repair, as well as cleft sidedness are similarly investigated. Methods: An Institutional Review Board approved, retrospective, single-center study at an academic children's hospital... περισσότερα »
Orientation of the Foramen Ovale
Orientation of the Foramen Ovale: An Anatomic Study With Neurosurgical Considerations: [image: image]Abstract: Unsuccessful cannulation of the foramen ovale (FO) continues to occur with both fluoroscopic technique and technique using computed tomography paired with navigational technology. Despite advances in stereotactic neurosurgical imaging and technique, anatomic variation of the FO occasionally prevents successful cannulation. Morphometric study of the FO has been limited to length, width, and area parameters; therefore, this report analyzed the orientation of the FO. A total o...περισσότερα »
Treated Versus Untreated Positional Head Deformity
Treated Versus Untreated Positional Head Deformity: [image: image] Background: Positional head deformity in early childhood is asserted to be a benign and in some cases spontaneously correcting entity encountered in craniofacial surgery. Although many authors have stated that helmet therapy is indicated in moderate and severe cases of deformational plagiocephaly and brachycephaly; others have reported resolution of these conditions within the first 2 to 3 years of life. A recent randomized controlled trial found that helmet therapy does not have beneficial effects for patients with... περισσότερα »
Removal of Long-Term Broken Roots Displaced Into the Maxillary Sinus by Endoscopic Assistant
Removal of Long-Term Broken Roots Displaced Into the Maxillary Sinus by Endoscopic Assistant: [image: image]Purpose: This report presented a patient with 2 long-term broken roots displaced in left maxillary sinus. The residual root fragments made the patient uncomfortable in both mind and body and interfered with prosthodontics work. The application of endoscope combined with piezoelectric device both helps in removing the broken roots successfully with minimally surgical injury and preserves the residual alveolar bone. Methods: Computed tomography scans and 3-dimensional reconstruct...περισσότερα »
Parotid Gland Surgery
Eleven Years of Parotid Gland Surgery in a Plastic and Reconstructive Department: [image: image] Background: Salivary gland tumors are an uncommon entity, comprising 3% to 6% of all head and neck tumors. Approximately 75% to 80% occur in the parotid gland, and 80% are benign. It is difficult to establish epidemiologic characteristics of parotid gland tumors due to their low incidence. We performed a retrospective study to analyze clinical diagnostic and therapeutic features of patients submitted to parotid gland surgery. Methods: A retrospective study was performed, regarding all t...περισσότερα »
Primary Giant Echinococcosis of the Neck
Primary Giant Echinococcosis of the Neck: [image: image]Abstract: The authors report an isolated echinococcosis in a 17-year-old girl presented with swelling of right neck approximately 12 cm in diameters with no evidence of the disease elsewhere in the body. A thorough search of the literature revealed only a few cases of isolated cervical echinococcosis. Surgical procedure was planned for our case with the guidance of the magnetic resonance imaging, which showed right cystic mass and within a laminar membrane. Histopathologic report confirmed echinococcosis. In summary, this curre...περισσότερα »
Reconstruction of the Auricular Defect After Excision of Verrucous Carcinoma
Reconstruction of the Auricular Defect After Excision of Verrucous Carcinoma: [image: image] Abstract: Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma with a high local recurrence rate. Few studies of primary verrucous carcinoma of the auricle have reported on the surgical outcome. The authors present herein a case in which a verrucous carcinoma of the auricle was successfully removed and reconstructed using a retroauricular pull-through island flap, and the authors briefly review the relevant literature.
18F-FDG PET/CT as an inflammatory marker appeared to be a more appropriate imaging modality than 18F-NaF PET/CT in diagnosing ONJ
Utility of 18F-fluorodeoxy glucose and 18F-sodium fluoride positron emission tomography/computed tomography in the diagnosis of medication-related osteonecrosis of the jaw: A preclinical study in a rat model via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 14 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Yemi Kim, Ho-Young Lee, Hai-Jeon Yoon, Bom Sahn Kim PurposeThe aim of this study was to determine the clinical utility of positron emission tomography/computed tomography (PET/CT) using 18F-FDG and 18F-... περισσότερα »
Trigeminal Neuralgia Caused by Cerebellopontine Angle Arteriovenous Malformation Treated With Gamma Knife Radiosurgery
Trigeminal Neuralgia Caused by Cerebellopontine Angle Arteriovenous Malformation Treated With Gamma Knife Radiosurgery: [image: image]Abstract: Trigeminal neuralgia is a facial pain syndrome characterized as sudden onset and lightening-like sensation over somatosensorial branch(es) of fifth cranial nerve. Rarely, some underlying diseases or disorders could be diagnosed, such as multiple sclerosis, brain tumors, and vascular malformations. The authors present a 47-year-old man with trigeminal neuralgia over left V2 and V3 dermatomes. He had a previous transarterial embolization and l... περισσότερα »
Nasofacial angle and nasal prominence
: A quantitative investigation of idealized and normative values via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 14 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Farhad B. Naini, Martyn T. Cobourne, Umberto Garagiola, Fraser McDonald, David Wertheim PurposeA quantitative evaluation of the influence of the nasofacial angle on perceived attractiveness and threshold values of desire for rhinoplasty.Material and MethodsThe nasofacial angle of an idealized silhouette male Caucasian/white profile image was al... περισσότερα »
Iron labeled adipose stem cells and neovascularization in calvarial critical-sized defects
Iron labeled adipose stem cells and neovascularization in rabbit calvarial critical-sized defects. via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 14 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Olli-Pekka Lappalainen, Marianne Haapea, Raisa Serpi, Siri Lehtonen, Leena Ylikontiola, Jarkko Korpi, Willy Serlo, George K.B. Sándor ObjectiveThe aim of this study was to evaluate the presence of iron labelled adipose stem cells at the 2 week time point and vascular changes at the 2 and 6 we...περισσότερα »
Bilateral hypertrophy of masseteric and temporalis muscles
Bilateral hypertrophy of masseteric and temporalis muscles, our fifteen patients and review of literature: *OBJECTIVE:* The association of bilateral hypertrophy of temporalis and masseteric muscles is a rare clinical entity. The origin of the condition is unclear, causing cosmetic problems, pain, and functional impairment. *PATIENTS AND METHODS:* In this paper we analyzed 15 patients treated at the Department of Maxillo-Facial Surgery of the University of Naples Federico II, from 2000 to 2013, for temporalis and/or masseteric muscle hypertrophy, and in particular, a rare case of a ... περισσότερα »
Mandibular Advancement Device—Emergent Central Sleep Apnea Can Resolve Spontaneously: A Case Report
Mandibular Advancement Device—Emergent Central Sleep Apnea Can Resolve Spontaneously: A Case Report: The development of treatment emergent central sleep apnea (CSA) has been described after almost all obstructive sleep apnea (OSA) therapies. While the course of positive airway pressure (PAP) emergent CSA, is better established; little is known about the natural course of mandibular advancement device (MAD) emergent CSA. Previous reports failed to comment on its natural course or report treatment with advanced ventilator modes such as adaptive servoventilation. We describe spontaneo... περισσότερα »
Commercial Motor Vehicle Driver Obstructive Sleep Apnea Screening
Commercial Motor Vehicle Driver Obstructive Sleep Apnea Screening and Treatment in the United States: An Update and Recommendation Overview: No regulatory mandate exists in the United States (U.S.) for comprehensive obstructive sleep apnea (OSA) risk assessment and stratification for commercial motor vehicle (CMV) drivers. Current Federal Motor Carrier Safety Administration (FMCSA) requirements are outdated and depend largely on subjective report, a less reliable strategy in an occupational setting. Without FMCSA standards, sleep specialists, occupational medical examiners and empl...περισσότερα »
The Prevalence of Depression among Untreated Obstructive Sleep Apnea Patients Using a Standardized Psychiatric Interview
The Prevalence of Depression among Untreated Obstructive Sleep Apnea Patients Using a Standardized Psychiatric Interview: Study Objectives:The aims of this study were: (1) to use a standardized psychiatric interview, conducted by a trained psychologist to assess the prevalence of depression among patients with untreated OSA, and (2) to identify if OSA severity or other comorbid disorders (insomnia, hypertension, and diabetes) are related to depression among patients with untreated OSA. Methods:Participants were newly diagnosed patients with OSA (n = 284) waiting to start positi...περισσότερα »
Performance of a Portable Sleep Monitoring Device in Individuals with High Versus Low Sleep Efficiency
Performance of a Portable Sleep Monitoring Device in Individuals with High Versus Low Sleep Efficiency: Study Objectives:Portable and automated sleep monitoring technology is becoming widely available to consumers, and one wireless system (WS) has recently surfaced as a research tool for sleep and sleep staging assessment outside the hospital/laboratory; however, previous research findings indicate low sensitivity for wakefulness detection. Because difficulty discriminating between wake and sleep is likely to affect staging performance, we sought to further evaluate the WS by com... περισσότερα »
Mechanism of Gastroesophageal Reflux in Obstructive Sleep Apnea: Airway Obstruction or Obesity?
Mechanism of Gastroesophageal Reflux in Obstructive Sleep Apnea: Airway Obstruction or Obesity?: Study Objectives:This is the first study to compare reflux events during wake and sleep in obese and non-obese individuals with obstructive sleep apnea (OSA) and obese individuals without OSA. The primary aim of the study was to investigate any additive effect of OSA on gastroesophageal reflux (GER) above that of obesity. Methods:Twenty obese individuals (body mass index, BMI > 30 kg/m2), 9 non-obese individuals (BMI < 30 kg/m2) with moderate-to-severe OSA, and 17 obese control subj...περισσότερα »
International Restless Legs Syndrome Sum Score in Patients with Restless Legs Syndrome (Willis-Ekbom Disease)
Post Hoc Analysis of Data from Two Clinical Trials Evaluating the Minimal Clinically Important Change in International Restless Legs Syndrome Sum Score in Patients with Restless Legs Syndrome (Willis-Ekbom Disease): Study Objectives:Determine the minimal clinically important change (MCIC), a measure determining the minimum change in scale score perceived as clinically beneficial, for the international restless legs syndrome (IRLS) and restless legs syndrome 6-item questionnaire (RLS-6) in patients with moderate to severe restless legs syndrome (RLS/Willis-Ekbom disease) treated w... περισσότερα »
Upper Airway Stimulation for Obstructive Sleep Apnea
Upper Airway Stimulation for Obstructive Sleep Apnea: Self-Reported Outcomes at 24 Months: Objectives:To evaluate the long-term (24-mo) effect of cranial nerve upper airway stimulation (UAS) therapy on patient-centered obstructive sleep apnea (OSA) outcome measures. Methods:Prospective, multicenter, cohort study of 126 patients with moderate to severe OSA who had difficulty adhering to positive pressure therapy and received the surgically implanted UAS system. Outcomes were measured at baseline and postoperatively at 12 mo and 24 mo, and included self- and bedpartner-report o... περισσότερα »
Non-Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea Using Cardiopulmonary Coupling
A Comparison of Different Success Definitions in Non-Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea Using Cardiopulmonary Coupling: Study Objectives:The definition and the criteria for the successful treatment of obstructive sleep apnea vary, depending on the study. This study aimed to compare different success criteria of non-continuous positive airway pressure (non-CPAP) treatment for obstructive sleep apnea in terms of sleep quality by using cardiopulmonary coupling. Methods:We included 98 patients who had been treated with sleep surgery or with a ...περισσότερα »
Evaluation of Bone Mineral Density by Computed Tomography in Patients with Obstructive Sleep Apnea
Evaluation of Bone Mineral Density by Computed Tomography in Patients with Obstructive Sleep Apnea: Study Objectives:Clinical studies have investigated whether obstructive sleep apnea (OSA) can modulate bone metabolism but data are conflicting. Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry is the standard technique for quantifying bone strength but has limitations in overweight patients (body mass index [BMI] ≥ 25 kg/m2). The aim of this study was to examine the association between OSA and BMD by examining CT images that allow true volumetric measurement... περισσότερα »
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea: Study Objectives:To investigate the respiratory effects of suvorexant, an orexin receptor antagonist for treating insomnia, in patients with obstructive sleep apnea (OSA). Methods:This was a randomized, double-blind, placebo-controlled, 2-period (4 days per period), crossover, sleep laboratory study. Twenty-six patients aged 18–65 years with mild (apnea-hypopnea index [AHI] ≥ 5 and < 15) to moderate (AHI ≥ 15 and < 30) OSA were randomized to receive suvorex...περισσότερα »
Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: A systematic review and meta-analysis
Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: A systematic review and meta-analysis: Pharmacotherapy has been used as an adjunct to CPAP for treatment of residual excessive sleepiness in patients with a diagnosis of obstructive sleep apnea syndrome (OSAS). However, no studies with a high level of evidence have been conducted to support this practice and confirm its effectiveness. We conducted a meta-analysis to summarize and quantify the effects of pharmacological treatment in adults with OSAS who expe... περισσότερα »
Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.
*Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.* Int J Audiol. 2016 Jan 14;:1-10 Authors: McCullagh MC, Banerjee T, Cohen MA, Yang JJ Abstract OBJECTIVE: The purpose of this study was to compare the effectiveness of three interventions designed to promote hearing protector device (HPD) use. DESIGN: Randomized controlled trial. STUDY SAMPLE: Farm operators (n = 491) were randomly assigned to one of five intervention groups: (1) interactive web-based information with mailed assortment of HPDs; (2) Interactive web-based infor... περισσότερα »
Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.
*Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.* Int J Audiol. 2016 Jan 14;:1-8 Authors: Bouserhal RE, Macdonald EN, Falk TH, Voix J Abstract OBJECTIVE: Speech production in noise with varying talker-to-listener distance has been well studied for the open ear condition. However, occluding the ear canal can affect the auditory feedback and cause deviations from the models presented for the open-ear condition. Communication is a main concern for people wearing ... περισσότερα »
Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.
*Effects of interventions on use of hearing protectors among farm operators: A randomized controlled trial.* Int J Audiol. 2016 Jan 14;:1-10 Authors: McCullagh MC, Banerjee T, Cohen MA, Yang JJ Abstract OBJECTIVE: The purpose of this study was to compare the effectiveness of three interventions designed to promote hearing protector device (HPD) use. DESIGN: Randomized controlled trial. STUDY SAMPLE: Farm operators (n = 491) were randomly assigned to one of five intervention groups: (1) interactive web-based information with mailed assortment of HPDs; (2) Interactive web-based infor... περισσότερα »
Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.
*Variations in voice level and fundamental frequency with changing background noise level and talker-to-listener distance while wearing hearing protectors: A pilot study.* Int J Audiol. 2016 Jan 14;:1-8 Authors: Bouserhal RE, Macdonald EN, Falk TH, Voix J Abstract OBJECTIVE: Speech production in noise with varying talker-to-listener distance has been well studied for the open ear condition. However, occluding the ear canal can affect the auditory feedback and cause deviations from the models presented for the open-ear condition. Communication is a main concern for people wearing ... περισσότερα »
Prediction of oral appliance treatment outcomes in obstructive sleep apnea
Prediction of oral appliance treatment outcomes in obstructive sleep apnea: A systematic review: While oral appliances (OA) have demonstrated good efficacy in patients ranging from mild to severe levels of obstructive sleep apnea (OSA), this form of treatment is not completely effective in all patients. As a successful treatment response is not dependent solely on apnea hypopnea index severity, the prediction of OA treatment efficacy is of key importance for efficient disease management. This systematic review aims to investigate the accuracy of a variety of clinical and experimental...περισσότερα »
Polymicrobial Biofilm Studies
Polymicrobial Biofilm Studies: from Basic Science to Biofilm Control: AbstractMicrobes rarely exist as single species planktonic forms as they have been commonly studied in the laboratory. Instead, the vast majority exists as part of complex polymicrobial biofilm communities attached to host and environmental surfaces. The oral cavity represents one of the most diverse and well-studied polymicrobial consortia. Despite a burgeoning field of mechanistic biofilm research within the past decades, our understanding of interactions that occur between microbial members within oral biofilm... περισσότερα »
Vocal imitations of basic auditory features
Vocal imitations of basic auditory features: Describing complex sounds with words is a difficult task. In fact, previous studies have shown that vocal imitations of sounds are more effective than verbal descriptions [Lemaitre and Rocchesso (2014). J. Acoust. Soc. Am. 135, 862–873]. The current study investigated how vocal imitations of sounds enable their recognition by studying how two expert and two lay participants reproduced four basic auditory features: pitch,tempo, sharpness, and onset. It used 4 sets of 16 referent sounds (modulated narrowband noises and pure tones), based o...περισσότερα »
Mandarin speech-in-noise and tone recognition using vocoder simulations of the temporal limits encoder for cochlear implants
Mandarin speech-in-noise and tone recognition using vocoder simulations of the temporal limits encoder for cochlear implants: Temporal envelope-based signal processing strategies are widely used in cochlear-implant(CI) systems. It is well recognized that the inability to convey temporal fine structure (TFS) in the stimuli limits CI users' performance, but it is still unclear how to effectively deliver the TFS. A strategy known as the temporal limits encoder (TLE), which employs an approach to derive the amplitude modulator to generate the stimuli coded in an interleaved-sampling st... περισσότερα »
Seeking Hearing Help for the First Time
Description of Adults Seeking Hearing Help for the First Time According to Two Health Behavior Change Approaches: Transtheoretical Model (Stages of Change) and Health Belief Model.: Objectives: Several models of health behavior change are commonly used in health psychology. This study applied the constructs delineated by two models-the transtheoretical model (in which readiness for health behavior change can be described with the stages of precontemplation, contemplation and action) and the health belief model (in which susceptibility, severity, benefits, barriers, self-efficacy, and... περισσότερα »
The Future of Surgical Oncology: Image-Guided Cancer Surgery.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
The Future of Surgical Oncology: Image-Guided Cancer Surgery. JAMA Surg. 2016 Jan 13;:1-2 Authors: Singhal S PMID: 26765107 [PubMed – as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1OSYiL6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2040cwk via IFTTT
Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes. J Clin Endocrinol Metab. 2016 Jan 14;:jc20154026 Authors: Shetty VB, Fournier PA, Davey RJ, Retterath AJ, Paramalingam N, Roby HC, Cooper MN, Davis EA, Jones TW Abstract CONTEXT: No recommendations exist to inform the carbohydrate amount required to prevent […]
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Molecular Heterogeneity in Aldosterone-Producing Adenomas. J Clin Endocrinol Metab. 2016 Jan 14;:jc20153239 Authors: Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE Abstract CONTEXT: The use of next generation sequencing (NGS) has resulted in the identification of recurrent somatic mutations underlying primary aldosteronism (PA). However, significant […]
Does the intravenous administration of frusemide reduce endolymphatic hydrops?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Does the intravenous administration of frusemide reduce endolymphatic hydrops? J Laryngol Otol. 2016 Jan 14;:1-6 Authors: Fiorino F, Mattellini B, Vento M, Mazzocchin L, Bianconi L, Pizzini FB Abstract OBJECTIVE: To verify the hypothesis that intravenous frusemide reduces endolymphatic hydrops, as evaluated by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging following intratympanic gadolinium administration. METHODS: […]
Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children. J Laryngol Otol. 2016 Jan 14;:1-8 Authors: Skarzynski H, Matusiak M, Lorens A, Furmanek M, Pilka A, Skarzynski PH Abstract OBJECTIVE: In cochlear implantation, there are two crucial factors promoting hearing preservation: an atraumatic surgical approach and selection of […]
upper respiratory tract infection; +30 new citations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2016/01/15 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to […]
Cancer among circumpolar populations: an emerging public health concern.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Cancer among circumpolar populations: an emerging public health concern. Int J Circumpolar Health. 2016;75:29787 Authors: Young TK, Kelly JJ, Friborg J, Soininen L, Wong KO Abstract OBJECTIVES: To determine and compare the incidence of cancer among the 8 Arctic States and their northern regions, with special focus on 3 cross-national indigenous groups – Inuit, Athabaskan […]
Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication. Rev Esp Enferm Dig. 2016 Jan;108(1):51-52 Authors: Cholvi Calduch R, Fernández Moreno MC, Díaz-Tobarra M, Calvete Chornet J Abstract INTRODUCTION: Inflammatory myofibroblastic tumors (IMT) are rare neoplasms characterized by a proliferation of spindle-shaped cells with a stroma infiltrated by macrophages, lymphocytes […]
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Mol Biol Cell. 2016 Jan 13; Authors: Niwa Y, Suzuki T, Dohmae N, Simizu S Abstract R-spondin1 (Rspo1) is a secreted protein that enhances Wnt signaling, which has crucial functions in embryonic development and several cancers. C-mannosylation is a rare type of glycosylation and […]
OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES. Vet Radiol Ultrasound. 2016 Jan 13; Authors: George R, Smith A, Schleis S, Brawner W, Almond G, Kent M, Wypij J, Borrego J, Moore A, Keyerleber M, Kraiza S Abstract Tumors of the nasal cavity comprise approximately 1% of all […]
3D reconstruction and heat map of porcine recurrent laryngeal nerve anatomy: branching and spatial location
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Recurrent laryngeal nerve palsy is a common post-operative complication of many head and neck surgeries. Theoretically, the best treatment to restore partial function to a damaged recurrent laryngeal nerve would be reinnervation of the posterior cricoarytenoid muscle via anastomosis of the recurrent laryngeal and phrenic nerves. The pig is an excellent model of human laryngeal anatomy and physiology but a more thorough knowledge of porcine laryngeal anatomy is necessary before the pig can be used to improve existing surgical strategies, and develop new ones. This study first ident... περισσότερα »
Interaction between autumnal temperature-photoperiod and experimentally induced transient cold shock influences proliferative activity in the brain of an adult terrestrial heterothermic vertebrate, Rana bergeri (Günther, 1986)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
It has been shown previously that in adult *Rana esculenta*, caught in nature, cold-shocked and brain-injured, encephalic cell proliferation is increased when capture and experiment occurred in spring and depressed when they occurred in autumn. Upon exclusive thermal stress cell proliferation appeared weak in spring and intense in autumn. The present study has investigated cold-shocked, but otherwise uninjured *Rana bergeri* to assess the impact of autumnal environment on encephalic cell proliferation. Lowering temperature - natural or experimental - seemed to exert a mild stimula... περισσότερα »
News and Events
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Volume 91, Issue 12, December 2015, pages 973-973<br>10.3109/09553002.2015.1133876<br> from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1ldz5PJ via IFTTT
The effects of device position on the operator's radiation dose when using a handheld portable X-ray device.
*The effects of device position on the operator's radiation dose when using a handheld portable X-ray device.* Dentomaxillofac Radiol. 2016 Jan 14;:20150245 Authors: Makdissi J, Pawar RR, Johnson B, Chong BS Abstract INTRODUCTION: Handheld X-ray devices are now offered in dental practice. Handheld X-ray units challenge the concept of a restricted access 'controlled area' as they are held by the operator. Although an integral lead shield is provided, the distance from the body is variable, dependent on how the device is held. The aim of this paper was to investigate the level of ...περισσότερα »
Can cloud-based tools accelerate Alzheimer's disease drug discovery?
*Can cloud-based tools accelerate Alzheimer's disease drug discovery?* Expert Opin Drug Discov. 2016 Jan 14; Authors: Cacabelos R, Teijido O, Carril JC PMID: 26766514 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1RpCY23 via IFTTT
Clinicopathological significance of SIRT1 expression in colorectal cancer: a systematic review and meta analysis.
*Clinicopathological significance of SIRT1 expression in colorectal cancer: a systematic review and meta analysis.* Int J Surg. 2016 Jan 4; Authors: Zu G, Ji A, Zhou T, Che N Abstract PURPOSE: The relationship between SIRT1 and clinicopathological parameters of colorectal cancer (CRC) is controversial. To evaluate the clinicopathological and prognostic value of silent mating type information regulation 2 homolog-1 (SIRT1) expressions in patients with CRC, a meta-analysis was performed. METHODS: We conducted a meta-analysis to investigate the impact of SIRT1 on clinicopathologica...περισσότερα »
Six-year follow-up of patients treated with oncoplastic reduction mammoplasty: A Cohort Study.
*Six-year follow-up of patients treated with oncoplastic reduction mammoplasty: A Cohort Study.* Int J Surg. 2016 Jan 4; Authors: Kabir SA, Stallard S, Weiler-Mithoff E, Mansell J, Mallon E, Doughty JC, Romics L Abstract BACKGROUND: Current evidence for the oncological safety of oncoplastic breast conservation is poor as it is based mostly on short-term follow-up data. Hence, we report long-term recurrence rates in patients treated with oncoplastic reduction mammoplasty (ORM). METHODS: A prospectively maintained database was searched to identify patients who underwent ORM betwee...περισσότερα »
Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.
*Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20154026 Authors: Shetty VB, Fournier PA, Davey RJ, Retterath AJ, Paramalingam N, Roby HC, Cooper MN, Davis EA, Jones TW Abstract CONTEXT: No recommendations exist to inform the carbohydrate amount required to prevent hypoglycaemia associated with exercise of different intensities in individuals with type 1 diabetes (T1D). OBJECTIVE: The relationship between exercise intensity and carbohydrate requirements to maintain stable eu...περισσότερα »
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.
*Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153785 Authors: Hong N, Yoon HJ, Lee YH, Kim HR, Lee BW, Rhee Y, Kang ES, Cha BS, Lee HC Abstract CONTEXT: Recent animal studies showed that tumor-derived parathyroid hormone-related peptide (PTHrP) induced cancer cachexia by fat browning with increased energy expenditure; however clinical evidence from human data is insufficient. OBJECTIVE: We investigated whether serum PTHrP levels independently predicts weight loss (WL) ...περισσότερα »
Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.
*Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153303 Authors: Moreno-Navarrete JM, Blasco G, Xifra G, Karczewska-Kupczewska M, Stefanowicz M, Matulewicz N, Puig J, Ortega F, Ricart W, Straczkowski M, Fernández-Real JM Abstract CONTEXT: Different genetic and imaging iron markers are known to be increased in the liver, adipose tissue and brain of obese subjects. OBJECTIVE: We aimed to investigate these markers in human skeletal muscle. Design, setting, patients and outcome measures... περισσότερα »
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
*Molecular Heterogeneity in Aldosterone-Producing Adenomas.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153239 Authors: Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE Abstract CONTEXT: The use of next generation sequencing (NGS) has resulted in the identification of recurrent somatic mutations underlying primary aldosteronism (PA). However, significant gaps remain in our understanding of the relationship between tumor aldosterone synthase (CYP11B2) expression and somatic mutation status. OBJECTIVE: To investigate tumor CYP11B2 expression ... περισσότερα »
A 6 bp In Frame Germline Deletion In Exon 7 Of RET Leads To Increased RET Phosphorylation, ERK Activation And MEN2A.
*A 6 bp In Frame Germline Deletion In Exon 7 Of RET Leads To Increased RET Phosphorylation, ERK Activation And MEN2A.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20152948 Authors: Latteyer S, Klein-Hitpass L, Khandanpour C, Zwanziger D, Poeppel TD, Schmid KW, Führer D, Moeller LC Abstract CONTEXT: Multiple endocrine neoplasia (MEN) 2 is usually caused by missense mutations in the proto-oncogene RET. OBJECTIVE: To determine the mutation underlying MEN2A in a female patient diagnosed with bilateral pheochromocytoma at age 31 and with medullary thyroid carcinoma (MTC) six years later. ... περισσότερα »
Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.
*Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20152597 Authors: Merovci A, Abdul-Ghani M, Mari A, Solis Herrera C, Xiong J, Daniele G, Tripathy D, DeFronzo R Abstract AIM: To investigate the effect of lowering the plasma glucose and free fatty acid concentrations with dapagliflozin and acipimox, respectively, on insulin sensitivity and insulin secretion in T2DM individuals. METHODS: 14 male T2DM patients received an OGTT and euglycemic hyperinsulinemic clamp at baseline and w...περισσότερα »
Comparison of McGrath Series 3 and Macintosh Laryngoscopes for Tracheal Intubation in Patients With Normal Airway by Inexperienced Anesthetists: A Randomized Study.
*Comparison of McGrath Series 3 and Macintosh Laryngoscopes for Tracheal Intubation in Patients With Normal Airway by Inexperienced Anesthetists: A Randomized Study.* Medicine (Baltimore). 2016 Jan;95(2):e2514 Authors: Liu ZJ, Yi J, Guo WJ, Ma C, Huang YG Abstract Difficult and failed intubations account for the major causes of morbidity and mortality in current anesthetic practice. Several devices including McGrath Series 3 videolaryngoscope are available which may facilitate tracheal intubation by improving view of the larynx compared with Macintosh blade laryngoscopy. But no ... περισσότερα »
A COMBINED MORPHOMETRIC AND MOLECULAR APPROACH TO IDENTIFYING METACERCARIAE OF EUCLINOSTOMUM HETEROSTOMUM (DIGENEA: CLINOSTOMIDAE).
*A COMBINED MORPHOMETRIC AND MOLECULAR APPROACH TO IDENTIFYING METACERCARIAE OF EUCLINOSTOMUM HETEROSTOMUM (DIGENEA: CLINOSTOMIDAE).* J Parasitol. 2016 Jan 13; Authors: Caffara M, Locke SA, Cristanini C, Davidovich N, Markovich MP, Fioravanti ML Abstract Metacercariae of species of Euclinostomum have been found encysted in kidney, liver and muscles of several fish species while adults occur in the mouth, pharynx, larynx, trachea and upper esophagus of fish-eating birds. The aim of this work was to gather molecular and morphological data from the type species, Euclinostomum heter... περισσότερα »
Significant laryngeal destruction in a northern European cohort of Behçet's disease patients.
Related Articles *Significant laryngeal destruction in a northern European cohort of Behçet's disease patients.* Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S123-8 Authors: Fitzgerald CW, Adeeb F, Timon CV, Shine NP, Fraser AD, Hughes JP Abstract OBJECTIVES: Behçet's disease (BD) is a multisystem autoimmune disease of unknown origin typically affecting the triad of oral and genital mucosa and the eye. Limited data are available in the literature regarding the otolaryngology-related manifestations of BD, particularly in northern Europeans. This is a novel study detailing surpr...περισσότερα »
Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure.* PLoS One. 2014;9(3):e91615 Authors: Kojima T, Van Deusen M, Jerome WG, Garrett CG, Sivasankar MP, Novaleski CK, Rousseau B Abstract Because the vocal folds undergo repeated trauma during continuous cycles of vibration, the epithelium is routinely susceptible to damage during phonation. Excessive and prolonged vibration exposure is considered a significant predisp... περισσότερα »
Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.
*Effect of exercise intensity on glucose requirements to maintain euglycaemia during exercise in type 1 diabetes.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20154026 Authors: Shetty VB, Fournier PA, Davey RJ, Retterath AJ, Paramalingam N, Roby HC, Cooper MN, Davis EA, Jones TW Abstract CONTEXT: No recommendations exist to inform the carbohydrate amount required to prevent hypoglycaemia associated with exercise of different intensities in individuals with type 1 diabetes (T1D). OBJECTIVE: The relationship between exercise intensity and carbohydrate requirements to maintain stable eu...περισσότερα »
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.
*Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153785 Authors: Hong N, Yoon HJ, Lee YH, Kim HR, Lee BW, Rhee Y, Kang ES, Cha BS, Lee HC Abstract CONTEXT: Recent animal studies showed that tumor-derived parathyroid hormone-related peptide (PTHrP) induced cancer cachexia by fat browning with increased energy expenditure; however clinical evidence from human data is insufficient. OBJECTIVE: We investigated whether serum PTHrP levels independently predicts weight loss (WL) ...περισσότερα »
Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.
*Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153303 Authors: Moreno-Navarrete JM, Blasco G, Xifra G, Karczewska-Kupczewska M, Stefanowicz M, Matulewicz N, Puig J, Ortega F, Ricart W, Straczkowski M, Fernández-Real JM Abstract CONTEXT: Different genetic and imaging iron markers are known to be increased in the liver, adipose tissue and brain of obese subjects. OBJECTIVE: We aimed to investigate these markers in human skeletal muscle. Design, setting, patients and outcome measures... περισσότερα »
Lycopene reduces mortality in people with systemic lupus erythematosus: A pilot study based on the third national health and nutrition examination survey.
*Lycopene reduces mortality in people with systemic lupus erythematosus: A pilot study based on the third national health and nutrition examination survey.* J Dermatolog Treat. 2016 Jan 14;:1-6 Authors: Han GM, Han XF Abstract INTRODUCTION: Persistent inflammation and oxidative stress are the main mechanisms that increase the risks of cardiovascular disease-related morbidity and mortality in systemic lupus erythematosus (SLE). As a natural antioxidant, lycopene can alleviate oxidative stress and suppress inflammation. We hypothesized that lycopene could have the potential to re... περισσότερα »
In response to: Predictors for outcome of paper patch myringoplasty in patients with chronic tympanic membrane perforations.
*In response to: Predictors for outcome of paper patch myringoplasty in patients with chronic tympanic membrane perforations.* Eur Arch Otorhinolaryngol. 2016 Jan 13; Authors: Lou Z PMID: 26762387 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/2345wC5 via IFTTT
Does the intravenous administration of frusemide reduce endolymphatic hydrops?
*Does the intravenous administration of frusemide reduce endolymphatic hydrops?* J Laryngol Otol. 2016 Jan 14;:1-6 Authors: Fiorino F, Mattellini B, Vento M, Mazzocchin L, Bianconi L, Pizzini FB Abstract OBJECTIVE: To verify the hypothesis that intravenous frusemide reduces endolymphatic hydrops, as evaluated by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging following intratympanic gadolinium administration. METHODS: The study comprised 12 patients (7 females and 5 males, aged 19-74 years) with Ménière's disease. Disease duration ranged from 0.5... περισσότερα »
Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children.
*Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children.* J Laryngol Otol. 2016 Jan 14;:1-8 Authors: Skarzynski H, Matusiak M, Lorens A, Furmanek M, Pilka A, Skarzynski PH Abstract OBJECTIVE: In cochlear implantation, there are two crucial factors promoting hearing preservation: an atraumatic surgical approach and selection of an electrode that does not damage cochlear structures. This study aimed to evaluate hearing preservation in children implanted with the Nucleus Slim Straight (CI422) electrode. METHODS: Nineteen c...περισσότερα »
upper respiratory tract infection; +30 new citations
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/01/15 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/QGMHBq(((upper%20respiratory%20tract%20infection)%20AND%20%222016%2F01%2... περισσότερα »
Cancer among circumpolar populations: an emerging public health concern.
*Cancer among circumpolar populations: an emerging public health concern.* Int J Circumpolar Health. 2016;75:29787 Authors: Young TK, Kelly JJ, Friborg J, Soininen L, Wong KO Abstract OBJECTIVES: To determine and compare the incidence of cancer among the 8 Arctic States and their northern regions, with special focus on 3 cross-national indigenous groups - Inuit, Athabaskan Indians and Sami. METHODS: Data were extracted from national and regional statistical agencies and cancer registries, with direct age-standardization of rates to the world standard population. For comparison, th... περισσότερα »
Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication.
*Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication.* Rev Esp Enferm Dig. 2016 Jan;108(1):51-52 Authors: Cholvi Calduch R, Fernández Moreno MC, Díaz-Tobarra M, Calvete Chornet J Abstract INTRODUCTION: Inflammatory myofibroblastic tumors (IMT) are rare neoplasms characterized by a proliferation of spindle-shaped cells with a stroma infiltrated by macrophages, lymphocytes and plasma cells. CASE REPORT: We report a case of 59 years old male who presented an acute abdomen due to a mass of the mesentery of the terminal i... περισσότερα »
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells.
*Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells.* Mol Biol Cell. 2016 Jan 13; Authors: Niwa Y, Suzuki T, Dohmae N, Simizu S Abstract R-spondin1 (Rspo1) is a secreted protein that enhances Wnt signaling, which has crucial functions in embryonic development and several cancers. C-mannosylation is a rare type of glycosylation and might regulate secretion, protein-protein interactions, and enzymatic activity. Although human Rspo1 contains 2 predicted C-mannosylation sites, C-mannosylation of Rspo1 has not been reported, nor have its functional ef...περισσότερα »
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
*Molecular Heterogeneity in Aldosterone-Producing Adenomas.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20153239 Authors: Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE Abstract CONTEXT: The use of next generation sequencing (NGS) has resulted in the identification of recurrent somatic mutations underlying primary aldosteronism (PA). However, significant gaps remain in our understanding of the relationship between tumor aldosterone synthase (CYP11B2) expression and somatic mutation status. OBJECTIVE: To investigate tumor CYP11B2 expression ... περισσότερα »
A 6 bp In Frame Germline Deletion In Exon 7 Of RET Leads To Increased RET Phosphorylation, ERK Activation And MEN2A.
*A 6 bp In Frame Germline Deletion In Exon 7 Of RET Leads To Increased RET Phosphorylation, ERK Activation And MEN2A.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20152948 Authors: Latteyer S, Klein-Hitpass L, Khandanpour C, Zwanziger D, Poeppel TD, Schmid KW, Führer D, Moeller LC Abstract CONTEXT: Multiple endocrine neoplasia (MEN) 2 is usually caused by missense mutations in the proto-oncogene RET. OBJECTIVE: To determine the mutation underlying MEN2A in a female patient diagnosed with bilateral pheochromocytoma at age 31 and with medullary thyroid carcinoma (MTC) six years later. ... περισσότερα »
Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.
*Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.* J Clin Endocrinol Metab. 2016 Jan 14;:jc20152597 Authors: Merovci A, Abdul-Ghani M, Mari A, Solis Herrera C, Xiong J, Daniele G, Tripathy D, DeFronzo R Abstract AIM: To investigate the effect of lowering the plasma glucose and free fatty acid concentrations with dapagliflozin and acipimox, respectively, on insulin sensitivity and insulin secretion in T2DM individuals. METHODS: 14 male T2DM patients received an OGTT and euglycemic hyperinsulinemic clamp at baseline and w...περισσότερα »
ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH.* Mol Cancer. 2015;14:84 Authors: Zheng G, Peng C, Jia X, Gu Y, Zhang Z, Deng Y, Wang C, Li N, Yin J, Liu X, Lu M, Tang H, He Z Abstract BACKGROUND: Chemoresistance is a major obstacle in successfully treating cancers, and the mechanisms responsible for drug resistance are still far from understood. Carbonic anhydrase 9 (CA9) has been shown to be upregulat...περισσότερα »
Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships.* Free Radic Biol Med. 2015 Feb;79:281-91 Authors: Hielscher A, Gerecht S Abstract Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia activates the transcription of a number of genes that sustain tumor progression. Since the seminal discovery of HIF-1α as a hypo... περισσότερα »
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.* Head Neck. 2015 May;37(5):763-70 Authors: Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S Abstract Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and tobacco consumption. Lately, the incidence of human papillomavirus (HPV)-related tumors has shown a significant increase, and HPV-relate...περισσότερα »
health technology; +154 new citations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
154 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2016/01/15 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content […]
A retrospective review of pediatric difficult airways: once easy, not always easy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J6EVxJ via IFTTT
Palliative care initiated in the ED associated with improved quality of life
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A palliative care consultation initiated in the emergency department (ED) for patients with advanced cancer was associated with improved quality of life and did not seem to shorten survival, according to an article published online by JAMA… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TZTlQS via IFTTT
Breast cancer study suggests new potential drug targets and combinations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The largest analysis of breast cancer cell function to date suggests dozens of new uses for existing drugs, new targets for drug discovery, and new drug combinations. The authors say the study results, published online in the journal Cell, will be seized… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J6DY8R via IFTTT
New particle can track chemotherapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tracking the path of chemotherapy drugs in real time and at a cellular level could revolutionise cancer care and help doctors sort out why two patients might respond differently to the same treatment. Researchers at The Ohio State University have found a… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J6DWhc via IFTTT
Study finds how diabetes drug metformin inhibits progression of pancreatic cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer. In their report that has been published in the open access journal PLOS… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J6DXSg via IFTTT
Researchers kill drug-resistant lung cancer with 50 times less chemotherapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The cancer drug paclitaxel just got more effective. For the first time, researchers from the University of North Carolina at Chapel Hill have packaged it in containers derived from a patient’s own immune system, protecting the drug from being destroyed… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J6DW0G via IFTTT
WHAT’S UP DOC? What is the treatment for thyroid cancer? – Wicked Local
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Wicked Local WHAT’S UP DOC? What is the treatment for thyroid cancer? Wicked Local Q: My friend was diagnosed with thyroid cancer and has to get radioactive iodine treatment. What can you tell me about this? A: The thyroid is a butterfly-shaped gland in the front of the lower neck which makes thyroid hormone. Cancer […]
New UK bowel and cervical screening recommendations https://t.co/cBZEyLJ1uu
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
New UK bowel and cervical screening recommendations https://t.co/cBZEyLJ1uu from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/687948125428842499 via IFTTT
Impact of Endocrine Disruptors on the Thyroid Hormone System
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The thyroid hormone (TH) system plays a central role in central physiological processes of many species, including mammals and humans, ranging from growth and cell differentiation, energy metabolism, thermoregulation and phasing of hibernation or annual movements of migratory species, metamorphosis from larvae to adult forms, brain development, reproduction, or the cardiovascular system. Several chemicals are […]
The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives: Favorable phase I results justified this pilot phase II study to assess the efficacy of docetaxel/curcumin in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (CRPC). Methods: Thirty patients with progressing CRPC and a rising prostate-specific antigen (PSA) received docetaxel/prednisone in standard conditions for 6 cycles in combination with per os curcumin, 6,000 mg/day (day […]
Changes in Total Lesion Glycolysis Evaluated by Repeated F-18 FDG PET/CT as Prognostic Factor in Locally Advanced Esophageal Cancer Patients Treated with Preoperative Chemoradiotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aims: The present study was aimed to investigate whether volumetric parameters measured by sequential F-18 fluoro-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) could be used as prognostic factors in patients with locally advanced esophageal cancer (LAEC) who received preoperative chemoradiotherapy (CRT). Methods: A total of 61 patients with LAEC were included in the current […]
Effect of biogeochemical interactions on bioaccessibility of arsenic in soils of a former smelter site in Republic of Korea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The total concentration-based regulations for soil remediation do not consider the possible changes in bioaccessibility of remaining arsenic (As) in soils due to biogeochemical interactions after remediation. This study used As-contaminated soil and pore water samples that were collected from the rice paddy and forest/farmland located in the vicinity of a former smelter site […]
Diseases, Vol. 4, Pages 4: Obesity and Prader-Willi Syndrome Affect Heart Rate Recovery from Dynamic Resistance Exercise in Youth
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Following exercise, heart rate decline is initially driven by parasympathetic reactivation and later by sympathetic withdrawal. Obesity delays endurance exercise heart rate recovery (HRR) in both children and adults. Young people with Prader-Willi Syndrome (PWS), a congenital cause for obesity, have shown a slower 60-s endurance exercise HRR compared to lean and obese children, suggesting […]
High-content cell death imaging using quantum dot-based TIRF microscopy for the determination of anticancer activity against breast cancer stem cell
We report a two color monitoring of drug-induced cell deaths using total internal reflection fluorescence (TIRF) as a novel method to determine anticancer activity. Instead of cancer cells, breast cancer stem cells (CSCs) were directly tested in the present assay to determine the effective concentration (EC50) values of camptothecin and cisplatin. Phosphatidylserine and HMGB1 protein… Continue reading High-content cell death imaging using quantum dot-based TIRF microscopy for the determination of anticancer activity against breast cancer stem cell
Atmosphere, Vol. 7, Pages 10: “It Was Raining All the Time!”: Ex Post Tourist Weather Perceptions
The importance of weather for tourism is now widely recognized. However, no research has so far addressed weather events from retrospective viewpoints, and, in particular, the role of “extreme” events in longer-term holiday memories. To better understand the character of ex post weather experiences and their importance in destination image perceptions and future travel planning… Continue reading Atmosphere, Vol. 7, Pages 10: “It Was Raining All the Time!”: Ex Post Tourist Weather Perceptions
Depression in women: Understanding the gender gap
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1dIvm6i via IFTTT
Bone health: Tips to keep your bones healthy
Wondering how to keep your bones strong and healthy? Follow these tips to take care of your bones. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nn8Esx via IFTTT
Nutrition for kids: Guidelines for a healthy diet
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Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp
Abstract Background An outbreak of eye diseases occurred among workers at a poultry abattoir in South Korea from December 2012 to June 2013. An epidemiological investigation of the causative agent was conducted. The workers were given a special health examination and workplace environmental monitoring was performed. Workers with ocular symptoms subsequently underwent an ophthalmic examination.… Continue reading Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp
Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family
Abstract Background Dysfunctions in the PI3K/mTOR pathway have gained a lot of attention in autism research. This was initially based on the discovery of several monogenic autism spectrum disorders with mutations or defects in PI3K/mTOR signaling components. Recent genetic studies corroborate that defective PI3K/mTOR signaling might be a shared pathomechanism in autism disorders of so… Continue reading Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family
A randomized, placebo-controlled trial of d -cycloserine for the enhancement of social skills training in autism spectrum disorders
Abstract Background Researchers have demonstrated that d-cycloserine (DCS) can enhance the effects of behavioral interventions in adults with anxiety and enhances prosocial behavior in animal models of autism spectrum disorders (ASD). This study extended upon this background by combining DCS with behavioral social skills therapy in youth with ASD to assess its impact on the… Continue reading A randomized, placebo-controlled trial of d -cycloserine for the enhancement of social skills training in autism spectrum disorders
The Clinical Internship for Radiology
Publication date: Available online 14 January 2016 Source:Academic Radiology Author(s): Valerie P. Jackson from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZzMQLn via IFTTT
First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells
Background: Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use… Continue reading First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells
Effect of biogeochemical interactions on bioaccessibility of arsenic in soils of a former smelter site in Republic of Korea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The total concentration-based regulations for soil remediation do not consider the possible changes in bioaccessibility of remaining arsenic (As) in soils due to biogeochemical interactions after remediation. This study used As-contaminated soil and pore water samples that were collected from the rice paddy and forest/farmland located in the vicinity of a former smelter site […]
Diseases, Vol. 4, Pages 4: Obesity and Prader-Willi Syndrome Affect Heart Rate Recovery from Dynamic Resistance Exercise in Youth
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Following exercise, heart rate decline is initially driven by parasympathetic reactivation and later by sympathetic withdrawal. Obesity delays endurance exercise heart rate recovery (HRR) in both children and adults. Young people with Prader-Willi Syndrome (PWS), a congenital cause for obesity, have shown a slower 60-s endurance exercise HRR compared to lean and obese children, suggesting […]
Erratum to: Ethnoichthyology of the indigenous Truká people, Northeast Brazil
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RptPqf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Trio of autism-linked molecules orchestrate neuron connections
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Proteins linked to brain disorders help wire the brain.New research from Duke University reveals how three proteins work in concert to wire up a specific area of the developing brain that is… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RpqzuY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Brain waves may be spread by weak electrical field
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Mechanism tied to waves associated with epilepsy.Researchers at Case Western Reserve University may have found a new way information is communicated throughout the brain. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/2340hT9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
An IRCM team unveils a mechanism that controls neuron production from stem cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The discovery could contribute to the development of cell therapies and more targeted treatments against cancer. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1J6xEOG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
First human in vitro model of rare neurodegenerative condition created
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Researchers at University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/203NJsu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Viruses, Vol. 8, Pages 19: Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”. These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A was more divergent than CiHHV-6B by examining four genes in 44 European CiHHV-6A/B cardiac/haematology patients. […]
A Nonrewarding NMDA Receptor Antagonist Impairs the Acquisition, Consolidation, and Expression of Morphine Conditioned Place Preference in Mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract N-methyl-d-aspartate (NMDA) receptor antagonists block morphine-induced conditioned place preference (CPP). Although polyamines are endogenous modulators of the NMDA receptor, it is not known whether polyaminergic agents induce CPP or modulate morphine-induced CPP. Here, we examined whether polyamine ligands modify morphine CPP acquisition, consolidation, and expression. Adult male albino Swiss mice received saline (0.9 % […]
Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract There are different theories about the pathophysiology of sepsis-associated encephalopathy (SAE), and the majority of our knowledge was derived from critically ill patients. 7In less severe sepsis, it is probable that neuroinflammation can be a major aspect of SAE development. We hypothesized that in non-severe septic patients, blood biomarkers of inflammation, endothelial activation, coagulation, […]
Relationship between thin-film bond strength as measured by a scratch test, and indentation hardness for bonding agents
Publication date: Available online 14 January 2016 *Source:*Dental Materials Author(s): Shusuke Kusakabe, H. Ralph Rawls, Masato Hotta ObjectivesTo evaluate thin-film bond strength between a bonding agent and human dentin, using a scratch test, and the characteristics and accuracy of measurement.MethodsOne-step bonding agents (BeautiBond; Bond Force; Adper Easy Bond; Clearfil tri-S Bond) and two-step bonding agents (Cleafil SE Bond; FL-Bond II) were investigated in this study. Flat dentin surfaces were prepared for extracted human molars. The dentin surfaces were ground and bonding ...περισσότερα »
The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study
Objectives: Favorable phase I results justified this pilot phase II study to assess the efficacy of docetaxel/curcumin in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (CRPC). Methods: Thirty patients with progressing CRPC and a rising prostate-specific antigen (PSA) received docetaxel/prednisone in standard conditions for 6 cycles in combination with per os curcumin, 6,000 mg/day (day… Continue reading The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study
Changes in Total Lesion Glycolysis Evaluated by Repeated F-18 FDG PET/CT as Prognostic Factor in Locally Advanced Esophageal Cancer Patients Treated with Preoperative Chemoradiotherapy
Aims: The present study was aimed to investigate whether volumetric parameters measured by sequential F-18 fluoro-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) could be used as prognostic factors in patients with locally advanced esophageal cancer (LAEC) who received preoperative chemoradiotherapy (CRT). Methods: A total of 61 patients with LAEC were included in the current… Continue reading Changes in Total Lesion Glycolysis Evaluated by Repeated F-18 FDG PET/CT as Prognostic Factor in Locally Advanced Esophageal Cancer Patients Treated with Preoper... περισσότερα »
Effect of biogeochemical interactions on bioaccessibility of arsenic in soils of a former smelter site in Republic of Korea
Abstract The total concentration-based regulations for soil remediation do not consider the possible changes in bioaccessibility of remaining arsenic (As) in soils due to biogeochemical interactions after remediation. This study used As-contaminated soil and pore water samples that were collected from the rice paddy and forest/farmland located in the vicinity of a former smelter site… Continue reading Effect of biogeochemical interactions on bioaccessibility of arsenic in soils of a former smelter site in Republic of Korea
Diseases, Vol. 4, Pages 4: Obesity and Prader-Willi Syndrome Affect Heart Rate Recovery from Dynamic Resistance Exercise in Youth
Following exercise, heart rate decline is initially driven by parasympathetic reactivation and later by sympathetic withdrawal. Obesity delays endurance exercise heart rate recovery (HRR) in both children and adults. Young people with Prader-Willi Syndrome (PWS), a congenital cause for obesity, have shown a slower 60-s endurance exercise HRR compared to lean and obese children, suggesting… Continue reading Diseases, Vol. 4, Pages 4: Obesity and Prader-Willi Syndrome Affect Heart Rate Recovery from Dynamic Resistance Exercise in Youth
Erratum to: Ethnoichthyology of the indigenous Truká people, Northeast Brazil
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RptPqf via IFTTT
Trio of autism-linked molecules orchestrate neuron connections
Proteins linked to brain disorders help wire the brain.New research from Duke University reveals how three proteins work in concert to wire up a specific area of the developing brain that is… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RpqzuY via IFTTT
Brain waves may be spread by weak electrical field
Mechanism tied to waves associated with epilepsy.Researchers at Case Western Reserve University may have found a new way information is communicated throughout the brain. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/2340hT9 via IFTTT
An IRCM team unveils a mechanism that controls neuron production from stem cells
The discovery could contribute to the development of cell therapies and more targeted treatments against cancer. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1J6xEOG via IFTTT
First human in vitro model of rare neurodegenerative condition created
Researchers at University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/203NJsu via IFTTT
Viruses, Vol. 8, Pages 19: Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”. These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A was more divergent than CiHHV-6B by examining four genes in 44 European CiHHV-6A/B cardiac/haematology patients.… Continue reading Viruses, Vol. 8, Pages 19: Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites...περισσότερα »
Cancer among circumpolar populations: an emerging public health concern.
*Cancer among circumpolar populations: an emerging public health concern.* Int J Circumpolar Health. 2016;75:29787 Authors: Young TK, Kelly JJ, Friborg J, Soininen L, Wong KO Abstract OBJECTIVES: To determine and compare the incidence of cancer among the 8 Arctic States and their northern regions, with special focus on 3 cross-national indigenous groups - Inuit, Athabaskan Indians and Sami. METHODS: Data were extracted from national and regional statistical agencies and cancer registries, with direct age-standardization of rates to the world standard population. For comparison, th... περισσότερα »
Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication.
*Hemoperitoneum secondary to perforated inflammatory myofibroblastic tumor: A case report of an unusual complication.* Rev Esp Enferm Dig. 2016 Jan;108(1):51-52 Authors: Cholvi Calduch R, Fernández Moreno MC, Díaz-Tobarra M, Calvete Chornet J Abstract INTRODUCTION: Inflammatory myofibroblastic tumors (IMT) are rare neoplasms characterized by a proliferation of spindle-shaped cells with a stroma infiltrated by macrophages, lymphocytes and plasma cells. CASE REPORT: We report a case of 59 years old male who presented an acute abdomen due to a mass of the mesentery of the terminal i... περισσότερα »
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells.
*Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells.* Mol Biol Cell. 2016 Jan 13; Authors: Niwa Y, Suzuki T, Dohmae N, Simizu S Abstract R-spondin1 (Rspo1) is a secreted protein that enhances Wnt signaling, which has crucial functions in embryonic development and several cancers. C-mannosylation is a rare type of glycosylation and might regulate secretion, protein-protein interactions, and enzymatic activity. Although human Rspo1 contains 2 predicted C-mannosylation sites, C-mannosylation of Rspo1 has not been reported, nor have its functional ef...περισσότερα »
OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES.
*OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES.* Vet Radiol Ultrasound. 2016 Jan 13; Authors: George R, Smith A, Schleis S, Brawner W, Almond G, Kent M, Wypij J, Borrego J, Moore A, Keyerleber M, Kraiza S Abstract Tumors of the nasal cavity comprise approximately 1% of all neoplasms in dogs. Canine intranasal lymphoma is rare and reports evaluating the outcome of treatment are lacking. The goal of this observational, descriptive, multi-institutional study was to evaluate the overall median survival times (MSTs) in a ... περισσότερα »
Role of Human Papillomavirus in Penile Carcinomas Worldwide.
*Role of Human Papillomavirus in Penile Carcinomas Worldwide.* Eur Urol. 2016 Jan 4; Authors: Alemany L, Cubilla A, Halec G, Kasamatsu E, Quirós B, Masferrer E, Tous S, Lloveras B, Hernández-Suarez G, Lonsdale R, Tinoco L, Alejo M, Alvarado-Cabrero I, Laco J, Guimerà N, Poblet E, Lombardi LE, Bergeron C, Clavero O, Shin HR, Ferrera A, Felix A, Germar J, Mandys V, Clavel C, Tzardi M, Pons LE, Wain V, Cruz E, Molina C, Mota JD, Jach R, Velasco J, Carrilho C, López-Revilla R, Goodman MT, Quint WG, Castellsagué X, Bravo I, Pawlita M, Muñoz N, Bosch FX, de Sanjosé S, HPV VVAP study gr... περισσότερα »
Mucins and Wnt/β-catenin Signaling in Gastrointestinal Cancers: An Unholy Nexus.
*Mucins and Wnt/β-catenin Signaling in Gastrointestinal Cancers: An Unholy Nexus.* Carcinogenesis. 2016 Jan 13; Authors: Pai P, Rachagani S, Dhawan P, Batra SK Abstract The Wnt/β-catenin signaling pathway is indispensable for embryonic development, maintenance of adult tissue homeostasis, and repair of epithelial injury. Unsurprisingly, aberrations in this pathway occur frequently in many cancers and often result in increased nuclear β-catenin. While mutations in key pathway members, such as β-catenin and adenomatous polyposis coli, are early and frequent occurrences in most col...περισσότερα »
Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study.
*Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study.* Int J Clin Oncol. 2016 Jan 13; Authors: Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S Abstract BACKGROUND: Malignant granular cell tumors (MGCTs) are extremely rare neoplasms with only a limited number of studies published to date. The aim of this study is to elucidate the clinicopathological characteristics and prognostic factors of MGCTs. METHODS: This is a multi-institutional retrospective study of MGCTs with... περισσότερα »
Melanoma of the sinonasal mucosa: A report on the two cases and a review of the literature.
Related Articles *Melanoma of the sinonasal mucosa: A report on the two cases and a review of the literature.* Vojnosanit Pregl. 2015 Oct;72(10):937-41 Authors: Aleksić A, Gajanin R, Djurdjević D, Novaković Z, Vranjes D, Spremo S, Travar D, Guzina-Golac N, Tomić-Spirić V Abstract INTRODUCTION: Primary mucosal melanoma of the sinonasal tract is a rare neoplasm, accounting for less than 1% of all melanomas. It has an aggressive and unpredictable biologic behavior characterized by frequent incidence of local recurrence, local and distant metastasis of the disease. CASE REPORT: This ... περισσότερα »
Bilateral choroidal melanoma--case analysis and literature review.
Related Articles *Bilateral choroidal melanoma--case analysis and literature review.* Klin Oczna. 2015;117(2):92-5 Authors: Kowal J, Strzałka A, Markiewicz A, Romanowska-Dixon B, Bogdali A Abstract Uveal melanoma is the most common primary intraocular neoplasm in adults. Its bilateral localization is extremely rare. The aim of the paper is analysis of the cases of bilateral uveal melanoma. Five bilateral uveal melanoma patients were diagnosed in the Department of Ophtalmology and Ocular Oncology beetwen 1980 and 2014. Both eyes of four patients were threated with brachytherapy. F... περισσότερα »
[Treatment failure as a consequence of the diagnostic difficulties in a 52-year-old patient treated for the pancreatic abscess].
Related Articles *[Treatment failure as a consequence of the diagnostic difficulties in a 52-year-old patient treated for the pancreatic abscess].* Pol Merkur Lekarski. 2015 Oct;39(232):231-3 Authors: Pawłowski W, Dorobisz T, Ziomek A, Leśniak M, Chabowski M, Janczak D Abstract Hodgkin Lymphoma (HL) is a neoplastic disease of the lymphatic system, primary involving lymph nodes and extranodular organs. Despite successful combined chemotherapy, a proper and prompt diagnosis remains a difficult challenge. The case report documents the case of a 52-year-old patient, who had been dia... περισσότερα »
Magnetic resonance imaging findings of two sisters with Van der Knaap leukoencephalopathy.
Related Articles *Magnetic resonance imaging findings of two sisters with Van der Knaap leukoencephalopathy.* Neuroradiol J. 2015 Oct;28(5):519-22 Authors: Koç K, Koç P, Karaali K, Olgaç Dündar N, Şenol U, Canan A Abstract Megalencephalic leukoencephalopathy with subcortical cysts, or Van der Knaap leukoencephalopathy, is a rare disease which is characterised by macrocephaly and neurological disorders with autosomal recessive inheritance. Magnetic resonance imaging is very helpful for determining distinctive findings and distinguishing other diseases. We present the radiological... περισσότερα »
Lack of survival improvement with novel anti-myeloma agents for patients with multiple myeloma and central nervous system involvement: the Greek Myeloma Study Group experience.
[image: http:--production.springer.de-OnlineReso] Related Articles *Lack of survival improvement with novel anti-myeloma agents for patients with multiple myeloma and central nervous system involvement: the Greek Myeloma Study Group experience.* Ann Hematol. 2015 Dec;94(12):2033-42 Authors: Katodritou E, Terpos E, Kastritis E, Delimpasis S, Symeonidis AS, Repousis P, Kyrtsonis MC, Vadikolia C, Michalis E, Polychronidou G, Michael M, Papadaki S, Papathanasiou M, Kokoviadou K, Kioumi A, Vlachaki E, Hadjiaggelidou C, Kouraklis A, Patsias I, Gavriatopoulou M, Kotsopoulou M, Verrou E,... περισσότερα »
Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.* J Gastroenterol Hepatol. 2015 Mar;30 Suppl 1:78-84 Authors: Kohler I, Bronsert P, Timme S, Werner M, Brabletz T, Hopt UT, Schilling O, Bausch D, Keck T, Wellner UF Abstract BACKGROUND AND AIM: Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive biology and poor prognosis even after resection. Long-term survival is very rare and cannot be reli... περισσότερα »
Cutaneous epithelioid osteoblastoma.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Cutaneous epithelioid osteoblastoma.* Am J Dermatopathol. 2015 May;37(5):e61-3 Authors: Mohlman JS, Diaz KA, Schaber JD Abstract Epithelioid osteoblastomas (EOB) typically arise in the axial skeleton of young adults, but there are rare case reports of the lesion arising in soft tissue. To date, only 1 case has been reported in the skin, and it has been debated in the literature if that case was truly a neoplasm. With the availability of the new osteoblastic marker SAT2B, the authors present a case of an EOB with ...περισσότερα »
Enhanced ratio of signals enables digital mutation scanning for rare allele detection.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Enhanced ratio of signals enables digital mutation scanning for rare allele detection.* J Mol Diagn. 2015 May;17(3):284-92 Authors: Castellanos-Rizaldos E, Paweletz C, Song C, Oxnard GR, Mamon H, Jänne PA, Makrigiorgos GM Abstract The use of droplet digital PCR (ddPCR) for low-level DNA mutation detection in cancer, prenatal diagnosis, and infectious diseases is growing rapidly. However, although ddPCR has been implemented successfully for detection of rare mutations at pre-determined positions, no ddPCR adaptati...περισσότερα »
