Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Κυριακή 22 Απριλίου 2018

Alpha-lactose reverses liver injury via blockade of Tim-3-mediated CD8 apoptosis in sepsis

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Publication date: Available online 22 April 2018
Source:Clinical Immunology
Author(s): Zhengping Wei, Pingfei Li, Yao Yao, Hai Deng, Shengwu Yi, Cong Zhang, Han Wu, Xiuxiu Xie, Minghui Xia, Ran He, Xiang-Ping Yang, Zhao-Hui Tang
In sepsis, the liver plays a crucial role in regulating immune responses and is also a target organ for immune-related injury. Despite the critical function of CD8+ T cells against opportunistic viral infections, the CD8 immune response in the liver during sepsis remains elusive. Here we found that Tim-3 is highly up-regulated in liver CD8+ T cells in a mouse cecal ligation and puncture model and in peripheral blood CD8+ T cells of human patients with sepsis. The expression of Tim-3 in liver CD8+ T cells displayed a bi-phasic pattern and deletion of Tim-3 led to reduction of CD8+ T cell apoptosis. Administration of α-lactose, a molecule with a similar structure to galactin-9, reduced Tim-3 expression and liver injury in sepsis. Our results demonstrate that targeting Tim-3 to boost CD8+ T cell immune response may offer an improved outcome in patients with sepsis.



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slider test

 

The post slider test appeared first on American Thyroid Association.



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Outcomes of Anesthesia Selection in Endovascular Treatment of Acute Ischemic Stroke

Background: The association between anesthesia type and outcomes in patients with acute ischemic stroke undergoing endovascular treatment (EVT) remains a subject of ongoing debate. Methods: This prospective nonrandomized controlled trial included 149 consecutive patients with acute anterior circulation stroke who underwent EVT. The primary outcome was functional independence assessed by the modified Rankin Scale (mRS) after 3 months. Results: A total of 105 (70.5%) and 44 (29.5%) patients undergoing EVT who received conscious sedation (CS) and general anesthesia (GA), respectively. The patients who received GA had similar demographics and basic National Institute of Health Stroke Scale scores (17 vs. 16, P>0.05) as the patients who received CS. The recanalization time (304 vs. 311 min, P=0.940) and the recanalization rate (86.4% vs. 84.1%, P=0.170) did not differ between the patients receiving the different types of anesthesia. The National Institute of Health Stroke Scale at 24 hours was lower in the patients who received CS than in those who received GA (β=−2.26, 95% confidence interval, −5.30 to 0.79). The independence (modified Rankin Scale score 0 to 2) at 3 months was equal between patients who received GA and those who received CS (odds ratio=0.73, 95% confidence interval, 0.32-1.68). The mortality and the morbidity rates did not differ. Conclusions: The data indicated that the selection of GA or CS during EVT had no impact on the independent outcomes of patients with anterior circulation occlusion. Z.M. and R.H. contributed equally. Y.P., Z.M., and R.H.: helped with the study design and manuscript preparation. Y.W., J.L., and F.L.: helped with the data collection and manuscript preparation. X.H. helped with the patient recruitment. X.L. and Y.Z.: helped with the data collection. P.W. and Y.P.: helped with the data analyses. Clinical Trial Registration: www.clinicaltrials.gov (NCT02350283). The trial was funded by the 'Youth Program' (QML20150508) and Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201708) from the Beijing Municipal Administration of Hospitals and programs from National Science and Technology Major Project of China (2011BAI08B02, 2015BAI12B04, and 2015BAI12B02). The authors have no conflicts of interest to disclose. Address correspondence to: Ruquan Han, MD, PhD, Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantan Xili, Dongcheng District, Beijing 100050, PR China (e-mail: ruquan.han@gmail.com). Received November 28, 2017 Accepted March 12, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

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Effect of Dexmedetomidine on Cerebral Vasospasm and Associated Biomarkers in a Rat Subarachnoid Hemorrhage Model

Background: The α2 adrenergic agonist dexmedetomidine (DEX) has huge potential for protecting against cerebral vasospasm, a leading cause of death and disability after subarachnoid hemorrhage (SAH). Biomarker assays for SAH have recently emerged as tools for predicting vasospasm and outcomes. We investigated the effects of DEX on vasospasm and assessed relevant biomarkers in a rat SAH model. Methods: Male Wistar rats were randomly assigned to sham (n=10), vehicle (n=10), SAH (n=10), or SAH+ DEX (n=10) groups. The SAH and SAH+DEX groups received 0.3 mL injections of autologous blood into the cisterna magna, followed by intraperitoneal injections of normal saline or 10 μg/kg DEX. Forty-eight hours later, neurological deficits as well as the basilar artery (BA) wall thickness and cross-sectional area were measured. Cerebrospinal fluid (CSF) and blood samples were obtained to assess concentrations of interleukin (IL)-6, C-reactive protein (CRP), endothelin-1, and S100-β using enzyme-linked immunosorbent assays. Results: The SAH and SAH+DEX groups exhibited deteriorated neurological function as well as structural and morphological BA vasospasm. The SAH+DEX group showed an improved neurological function score (ie, a 52% decrease), a 10% reduction in wall thickness, and a BA cross-sectional area enlarged by 157%. Compared with the sham group, CSF levels of IL-6 and CRP in the SAH and SAH+DEX groups, as well as serum IL-6 and CRP levels in the SAH group, were significantly elevated. The SAH+DEX group showed significantly lower CSF IL-6 levels than the SAH group. Serum and CSF levels of endothelin-1 and S100-β were similar across all groups. Conclusions: DEX administration reduced the severity of cerebral vasospasm and improved neurological function in SAH rats; this may be closely linked to reduced CSF IL-6 levels. This study was supported by special research grant funded by the Korean Society of Neuroscience in Anesthesiology and Critical Care (KSNACC-2016) for Young Song. The remaining authors have no conflicts of interest to disclose. Address correspondence to: Dong Woo Han, MD, PhD, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, Republic of Korea (e-mail: hanesth@yuhs.ac). Received November 22, 2017 Accepted March 27, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

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Intracranial Space–occupying Lesion Inducing Intracranial Hypertension Increases the Encephalographic Effects of Isoflurane in a Swine Model

Background: Patients with a brain tumor are susceptible to the hypnotic effect of anesthetics depending on the tumor's size. We investigated whether intracranial space–occupying lesions (ICSOLs) inducing intracranial hypertension increase isoflurane's effect on electroencephalographic (EEG) results. Materials and Methods: After anesthetic induction with isoflurane, 11 swine were studied with regard to isoflurane's effect on EEGs at 0.5% to 2.0% inhalational concentration at sequential stages: baseline 1, ICSOL 1, baseline 2, ICSOL 2, baseline 3. At each ICSOL stage, an intracranial epidural balloon catheter was inflated and the intracranial pressure maintained at twice the baseline pressure. The balloon was deflated after each ICSOL stage (baselines 2 and 3). A 95% spectral edge frequency (SEF), which correlates with anesthetic hypnosis, was used to measure isoflurane's effect. Pharmacodynamics was characterized using a sigmoidal inhibitory maximum effect model for the SEF versus end-tidal concentration. Results: ICSOL shifted the relations between SEF and the effect-site concentration (Ce) downward. Baseline and 50% of the maximum spectral edge effect levels significantly decreased during balloon inflation. The Ce that produced SEF=15 was 1.12 (1.04-1.20) (mean [95% confidence interval])% for baseline 1; 0.92 (0.81-1.03) for ICSOL 1; 1.02 (0.94-1.11) for baseline 2; 0.88 (0.82-0.94) for ICSOL 2; 1.05 (0.93-1.17) for baseline 3. Isoflurane's effect on EEGs increased during balloon inflation, with the alteration tending to recover after balloon deflation. Conclusions: ICSOLs inducing intracranial hypertension increase the EEG effect of isoflurane, and external compression from the brain surface enhances the anesthetic hypnosis despite minimum brain injury. Support was provided solely from institutional and/or departmental sources. The authors have no conflicts of interest to disclose. Address correspondence to: Tadayoshi Kurita, MD, Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan (e-mail: tadkur@hama-med.ac.jp). Received December 20, 2017 Accepted March 22, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

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Surveying the Literature: Synopsis of Recent Key Publications

No abstract available

https://ift.tt/2Hm9zni

A Randomized Trial Comparing the Effect of Fiberoptic Selection and Guidance Versus Random Selection, Blind Insertion, and Direct Laryngoscopy, on the Incidence and Severity of Epistaxis After Nasotracheal Intubation

BACKGROUND: Epistaxis, or nasal bleeding, is a common complication after nasotracheal intubation (NTI). Because such bleeding is likely related to trauma during intubation, use of fiberoptic visualization and guidance rather than direct laryngoscopy may affect the incidence and severity of epistaxis. We compared the incidence of epistaxis after NTI using a fiberoptic versus a direct laryngoscopy approach. METHODS: Seventy patients who were able to breathe easily through unobstructed nostrils and required NTI as part of their anesthetic management were recruited. Exclusion criteria included unequal nasal airflow, nostril obstruction, previous nasal trauma or surgery, and coagulation abnormalities as determined by history. Patients were randomly assigned to undergo NTI with thermosoftened Mallinckrodt nasal Ring-Adair-Elwyn (RAE) tubes via either traditional direct laryngoscopy using a Macintosh blade or fiberoptic nasal intubation. All patients first underwent anesthetic induction and were randomized to blind or fiberoptic groups. Patients in the blind insertion/direct laryngoscopy group were then intubated via a randomly selected nostril. Patients in the fiberoptic group underwent an asleep nasal fiberoptic examination to determine the most patent nostril, followed by tube insertion under fiberoptic guidance. Ten minutes after NTI, the incidence and severity of epistaxis were evaluated and graded by the surgeon, who was blinded to the intubation method. RESULTS: Initial nasal fiberoptic endoscopy identified asymptomatic nasal pathology in 51% of patients: inferior turbinate hypertrophy (28.6%) and deviation of the nasal septum in (22.8%). The incidence of epistaxis was higher in the blind insertion/direct laryngoscopy group (88%) than in the fiberoptic group (51%; relative risk, 0.55; 95% confidence interval, 0.38–0.79; P = .0011). The severity of bleeding was also greater in the blind tube insertion/direct laryngoscopy cohort (Wilcoxon Mann-Whitney odds, 3.5; 95% confidence interval, 1.8–11.1). CONCLUSIONS: Fiberoptic nostril selection and guidance during NTI reduced the incidence and severity of epistaxis when compared with NTI performed via blind insertion and direct laryngoscopy. Accepted for publication March 14, 2018. Funding: None. Conflicts of Interest: See Disclosures at the end of the article. Reprints will not be available from the authors. Address correspondence to Jeffrey Leighton Tong, MD, FRCA, Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Ave, MC4028, Chicago, IL 60637. Address e-mail to jtong4@dacc.uchicago.edu. © 2018 International Anesthesia Research Society

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Caution When Dosing Anesthetic Medications: Are We Putting Too Much Weight on Patient Weight?

No abstract available

https://ift.tt/2F7YWCS

Comprehensive Pain Management in the Rehabilitation Patient

No abstract available

https://ift.tt/2HSpZ83

Can Lung Ultrasound Be the First-Line Tool for Evaluation of Intraoperative Hypoxemia?

No abstract available

https://ift.tt/2F7YR22

Hyperchloremic Intravenous Fluids Should Be Abandoned

No abstract available

https://ift.tt/2HQ9MQQ

Practical Anesthetic Management: The Art of Anesthesiology

No abstract available

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In Response

No abstract available

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Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry

BACKGROUND: Despite its central role in early trauma coagulopathy, abnormal fibrinolysis continues to be poorly understood. Excessive fibrinolysis is a known contributor to mortality. Recent studies with thromboelastography (TEG) suggest decreased fibrinolysis (or shutdown) may be just as harmful. Considering the broad use of 2 different viscoelastic assays, which are not interchangeable, we proposed for the first time to define and characterize fibrinolysis shutdown using rotational thromboelastometry (ROTEM). METHODS: Retrospective cohort study of severely injured patients with admission ROTEM. Shutdown was defined by the best Youden index value of the maximum lysis. Fibrinolysis phenotypes were physiologic, hyperfibrinolysis, and shutdown. Multivariable logistic regression evaluated association between Injury Severity Score and the fibrinolysis phenotypes, and the association among shutdown phenotype with mortality, blood transfusion, and thrombotic events. RESULTS: Five hundred fifty patients were included. Maximum lysis

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In Response

No abstract available

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Pharmacological Basis of Anesthesia: How to Overcome Stagnation?

No abstract available

https://ift.tt/2F7YtAC

Transesophageal Lung Ultrasound Should Be the First-Line Tool to Evaluate Intraoperative Hypoxia

No abstract available

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Gender Distribution of the American Board of Anesthesiology Diplomates, Examiners, and Directors (1985–2015)

To understand the potential role of women in leadership positions, data from the American Board of Anesthesiology (ABA) were analyzed to explore the impact of women in the specialty of anesthesiology. The number of newly certified ABA diplomates, oral examiners, and directors from 1985 to 2015 was obtained from the ABA database. The percentages of women in each group were calculated for each year. Because it took an average of 10 years for a diplomate to become an oral examiner and an average of 7 years for an oral examiner to be elected as a director during the study period, the following percentages were compared: women oral examiners versus newly certified women diplomates 10 years prior and women directors versus women oral examiners 7 years prior. The correlation coefficients between the percentages of women oral examiners and of newly certified women diplomates 10 years prior and between the percentages of women directors and women oral examiners 7 years prior were calculated. From 1985 to 2015, the percentage of newly certified women diplomates increased from 15% to 38% with an average annual increase of 0.74%, percentage of women oral examiners increased from 8% to 26% with an average annual increase of 0.63%, and percentage of women directors increased from 8% to 25% with an average annual increase of 0.56%. The percentage of women examiners consistently lagged behind the percentage of women diplomates who were certified 10 years earlier; the average difference over 21 years from 1995 to 2015 was −3.7% with a standard deviation of 2.1%. The correlation coefficient between the percentages of women examiners and newly certified women diplomates 10 years earlier from 1995 to 2015 was 0.86 (P

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The Brachiocephalic Vein as a Safe and Viable Alternative to Internal Jugular Vein for Central Venous Cannulation

BACKGROUND: Although many studies have compared success and complication rates for central line insertion sites with and without ultrasound, few have examined the use of the brachiocephalic vein for central venous access. The aim of this study was to describe the brachiocephalic vein as an alternative site for elective ultrasound vascular cannulation in adults, and to compare it with the more commonly used internal jugular vein site in terms of procedural difficulties, first pass failure rate, overall failure rate, and safety. METHODS: In this single-center, retrospective cohort study, clinical data from consecutive adult patients undergoing elective ultrasound-guided central venous catheterization of upper body were retrieved from the department database. All of these central venous catheters were requested by department team, none was positioned for surgery. Seven hundred nine patients underwent central venous catheterization via the internal jugular approach and 285 patients via the brachiocephalic route. Patients catheterized via the brachiocephalic vein approach were then compared with those catheterized via the internal jugular vein in terms of ease of catheterization, success rate, and complications. Differences between approaches were assessed by univariate analyses and multivariable analysis. RESULTS: Overall, 994 patients underwent central venous catheterization. A total of 87% had a successful catheter implantation at the first attempt, 6.7% of insertions were difficult, 5.7% were complicated, and 3.4% failed. Procedural difficulty was more frequent with the internal jugular than with the brachiocephalic approach (odds ratio, 0.38; 95% confidence interval, 0.19–0.76; P = .007) after correction for potential confounders. Differences between groups in complication rate (6.3% vs 4.1%) or failure rate (3.4% vs 3.5%) were not significant. CONCLUSIONS: Brachiocephalic cannulation is a reasonable alternative to ultrasound-guided internal jugular vein catheterization. Accepted for publication February 26, 2018. Funding: None. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Paolo Federico Beccaria, MD, Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132 Italy. Address e-mail to beccaria.paolo@hsr.it. © 2018 International Anesthesia Research Society

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Long-term continuous N-carbamylglutamate treatment in frequently decompensated propionic acidemia: a case report

Propionic acidemia is a rare autosomal recessive inherited metabolic disorder that can inhibit the synthesis of N-acetylglutamate, the obligatory activator in urea synthesis, leading to hyperammonemia. N-carbamyl...

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Case of meningothelial hamartoma with dermal melanocytosis in a patient with trichorhinophalangeal syndrome type II

The Journal of Dermatology, EarlyView.


https://ift.tt/2HiS63f

Drug‐induced hypersensitivity syndrome followed by chronic inflammatory demyelinating polyneuropathy

The Journal of Dermatology, EarlyView.


https://ift.tt/2qRQenc

Secondary calcification associated with subcutaneous sarcoidosis

The Journal of Dermatology, EarlyView.


https://ift.tt/2HjlpD1

Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia

The Journal of Dermatology, EarlyView.


https://ift.tt/2qQ8D3G

Normothermic Ex Vivo Kidney Perfusion Reduces Warm Ischemic Injury of Porcine Kidney Grafts Retrieved After Circulatory Death (DCD)

Background: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. Methods We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS. Results Following transplantation, the NEVKP group demonstrated lower daily serum creatinine levels indicating better early graft function compared with no-preservation (p=0.02) or static cold storage group (p

https://ift.tt/2F7xyF1

Split liver transplantation and pediatric waitlist mortality in the United States: potential for improvement

Background In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. Methods Using UNOS STAR data, we identified livers transplanted 2010-2015 that could potentially have been used for split transplant, based on strict criteria. Livers not suitable for pediatric patients or allocated to high-risk recipients were excluded. Number and distribution of potentially "split-able" livers were compared to pediatric waitlist deaths in each region. Results Of 37 333 deceased donor livers transplanted, 6.3% met our strict criteria for utilization in split liver transplant. Only 3.8% of these were actually utilized for split liver transplantation. 96% were utilized for a single adult recipient. Of the 2253 transplanted as whole livers, 82% of their recipients were listed as willing to accept a segmental liver, and only 3% were listed as requiring a cold ischemia time less than 6 hours. Over the same 5 years, 299 children died on the waitlist. In every UNOS region, there were more potentially "split-able" livers than pediatric waitlist deaths. 37% of pediatric waitlist deaths occurred at transplant centers that averaged ≤1 pediatric split liver transplant annually during the study period. Conclusion This comparison, while not conclusive, suggests that we might be missing opportunities to reduce pediatric waitlist mortality without decreasing access for adults—using split liver transplant. Barriers are significant, but further work on strategies to increase split liver transplant is warranted. Corresponding Author: Emily R. Perito, MD MAS, Pediatric Gastroenterology, Hepatology, and Nutrition, 550 16th Street, 5th Floor, Box 0136; San Francisco, CA 94143, Email: emily.perito@ucsf.edu Authorship: Emily R. Perito, MD MAS: Led study design, IRB approval, data analysis and interpretation, writing and revision of the manuscript. Garrett Roll, MD: Participated in study design, data interpretation, writing and revision of the manuscript. Jennifer L. Dodge, MPH: Participated in study design, led data analysis and interpretation, participated in writing and revision of the manuscript Sue Rhee, MD: Participated in study design, data interpretation, writing and revision of the manuscript. John P. Roberts, MD: Participated in study design, data interpretation, writing and revision of the manuscript. Funding and acknowledgements: This work was supported in part by Health Resources and Services Administration contract 234-2005-37011C (UNOS Data), the NIH-NIDDK (Dr. Perito, K23 DK0990253-A101), the UCSF Liver Center (P30 DK026743), and the UCSF Department of Pediatrics (Clinical/Translational Pilot Study Grant). The data reported here have been supplied by the Minneapolis Medical Research Foundation (MMRF) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and should not be seen as an official policy of or interpretation by the SRTR or the US Government. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, nor does mention of trades names, commercial products, or organizations imply endorsement by the US Government. Disclosures: The authors of this manuscript have no conflicts of interest to disclose as described by Transplantation. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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One Hundred and Fifteen Cases of Pure Laparoscopic Living Donor Right Hepatectomy at a Single Center

Background The pure laparoscopic approach to donor hepatectomy is being taken more often. However, few centers perform pure laparoscopic donor right hepatectomy (PLDRH) because it requires a high level of surgical skill. Studies reporting initial outcomes of PLDRH may prompt further implementation of the technique and help reduce initial learning curves at other transplant centers. This study reports performance of PLDRH at a single center with extensive experience of adult living donor liver transplantation. Methods Data from 115 donors (and recipients) who underwent PLDRH between November 2015 and June 2017 were analyzed retrospectively. Subgroup analysis was performed to compare outcomes between the initial (November 2015 to October 2016) and more recent (November 2016 to June 2017) periods. Results During the initial period, three donors (2.6%) experienced complications greater than grade III on the Clavien-Dindo scale. By contrast, no donors developed complications during the recent period. The operative time (293.6 vs 344.4 minutes; P

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How Should Social Media Be Used in Transplantation? A Survey of The American Society of Transplant Surgeons

Background Social media platforms are increasingly used in surgery and have shown promise as effective tools to promote deceased donation and expand living donor transplantation. There is growing need to understand how social media-driven communication is perceived by providers in the field of transplantation. Methods We surveyed 299 members of the American Society of Transplant Surgeons (ASTS) about their use of, attitudes toward, and perceptions of social media and analyzed relationships between responses and participant characteristics. Results Respondents used social media to communicate with: family and friends (76%), surgeons (59%), transplant professionals (57%), transplant recipients (21%), living donors (16%), and waitlisted candidates (15%). Most respondents (83%) reported using social media for at least one purpose. While most (61%) supported sharing information with transplant recipients via social media, 42% believed it should not be used to facilitate living donor-recipient matching. Younger age (p=0.02) and fewer years of experience in the field of transplantation (p=0.03) were associated with stronger belief that social media can be influential in living organ donation. Respondents at transplant centers with higher reported use of social media had more favorable views about sharing information with transplant recipients (p

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Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection

Chronic rejection is the Achilles' heel of modern lung transplantation, characterized by a slow, progressive decline in allograft function. Clinically, this manifests as obstructive disease, restrictive disease, or a mixture of the 2 depending on the underlying pathology. The 2 major phenotypes of chronic rejection include bronchiolitis obliterans syndrome and restrictive allograft syndrome. The last decade of research has revealed that each of these phenotypes has a unique underlying pathophysiology which may require a distinct treatment regimen for optimal control. Insights into the intricate alloimmune pathways contributing to chronic rejection have been gained from both large and small animal models, suggesting directions for future research. In this review, we explore the pathological hallmarks of chronic rejection, recent insights gained from both clinical and basic science research, and the current state of animal models of chronic lung rejection. Correspondence information: Daniel Kreisel, M.D., Ph.D. Professor of Surgery, Pathology & Immunology, Campus Box 8234, 660 South Euclid Avenue, Washington University School of Medicine, St. Louis, MO 63110, kreiseld@wustl.edu Authorship: Each author participated in the writing of this manuscript and approved the final version for submission Disclosure: DK is on the scientific advisory board of Compass Therapeutics. All other authors have nothing to disclose. Funding: No funding was received for this work. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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The biphasic effect of extracellular glucose concentration on carbachol‐induced fluid secretion from mouse submandibular glands

European Journal of Oral Sciences, EarlyView.


https://ift.tt/2F6vwFe

Obstacles to comprehensive dental care in patients with sustained limitations of their decision‐making abilities: findings from a Delphi study

European Journal of Oral Sciences, EarlyView.


https://ift.tt/2K71pRy

Masthead

The Laryngoscope, Volume 128, Issue 5, Page i-ii, May 2018.


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Table of contents

The Laryngoscope, Volume 128, Issue 5, Page iii-vii, May 2018.


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Surgical management of spontaneous cerebrospinal fistulas and encephaloceles of the temporal bone

The Laryngoscope, EarlyView.


https://ift.tt/2HIFkdR

Co‐culture of adipose‐derived stem cells and chondrocytes on three‐dimensionally printed bioscaffolds for craniofacial cartilage engineering

The Laryngoscope, EarlyView.


https://ift.tt/2qOqloO

Malignant melanoma association with systemic lupus erythematosus in a large midwestern U.S. patient population: a retrospective study

International Journal of Dermatology, EarlyView.


https://ift.tt/2qPk8sS

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

International Journal of Dermatology, EarlyView.


https://ift.tt/2vAYygt

Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2HROhyV

Nerve entrapment syndromes in dermatology: Review and practical approach to treatment

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2F7Pcs7

Oral lichenoid drug eruption in association with drinking tonic water

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2K4wfug

Dermoscopic features in two cases of acroangiodermatitis

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2F6KrPJ

Acute‐onset, painful acral granuloma annulare with unusual microcalcification

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2K4wci4

Changes in editorial office of JEADV – a big thank you, farewell and welcome

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 653-653, May 2018.


https://ift.tt/2K5izz5

Issue Information

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 647-652, May 2018.


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Forthcoming Events

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 840-840, May 2018.


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Announcement

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 841-841, May 2018.


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Commentary to: ‘Neck rejuvenation by direct anterior medial cervicoplasty: the modified zigzag‐plasty according to Tschopp’

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 656-656, May 2018.


https://ift.tt/2K5ivPR

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 657-682, May 2018.


https://ift.tt/2F5Mqnt

Classifying immunopathological responses in chronic inflammatory skin diseases

Journal of the European Academy of Dermatology and Venereology, Volume 32, Issue 5, Page 654-655, May 2018.


https://ift.tt/2K7YxnK

Inverse association for diagnosis of Alzheimer's disease subsequent to both melanoma and non‐melanoma skin cancers in a large, urban, single‐centre, Midwestern US patient population

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2JgSQ5E

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

British Journal of Dermatology, EarlyView.


https://ift.tt/2F6CB8N

Issue Information

British Journal of Dermatology, Volume 178, Issue 4, Page i-v, April 2018.


https://ift.tt/2HRKsd3

Stress and more stress: the importance in skin disease of worrying about what others think

British Journal of Dermatology, Volume 178, Issue 4, Page 821-822, April 2018.


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A comprehensive approach to evaluating and classifying sun‐protective clothing

British Journal of Dermatology, Volume 178, Issue 4, Page e299-e299, April 2018.


https://ift.tt/2HS6oF1

A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China

British Journal of Dermatology, Volume 178, Issue 4, Page e300-e300, April 2018.


https://ift.tt/2F8OQRY

Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative

British Journal of Dermatology, Volume 178, Issue 4, Page e297-e297, April 2018.


https://ift.tt/2HQbilU

HLA‐Cw6和银屑病

British Journal of Dermatology, Volume 178, Issue 4, Page e320-e320, April 2018.


https://ift.tt/2Hn5yyX

Herbal interventions: make the grass greener!

British Journal of Dermatology, Volume 178, Issue 4, Page 827-829, April 2018.


https://ift.tt/2HRwx71

Long‐term management of moderate‐to‐severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal

British Journal of Dermatology, Volume 178, Issue 4, Page e311-e311, April 2018.


https://ift.tt/2F4LijT

Association of APOE polymorphisms with multibacillary leprosy

British Journal of Dermatology, Volume 178, Issue 4, Page 833-834, April 2018.


https://ift.tt/2HQNFtE

Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients: a randomized intraindividual controlled trial

British Journal of Dermatology, Volume 178, Issue 4, Page e298-e298, April 2018.


https://ift.tt/2F6JIht

A platinum era for dermatology therapeutics?

British Journal of Dermatology, Volume 178, Issue 4, Page 836-837, April 2018.


https://ift.tt/2HRkRkA

Image Gallery: Brimonidine gel for facial erythema in Netherton syndrome

British Journal of Dermatology, Volume 178, Issue 4, Page e277-e277, April 2018.


https://ift.tt/2F7PFur

Atopic dermatitis: risk estimates for hand eczema

British Journal of Dermatology, Volume 178, Issue 4, Page 827-827, April 2018.


https://ift.tt/2HR3nF7

Use of the hCONSORT criteria as a reporting standard for herbal interventions for common dermatoses: a systematic review

British Journal of Dermatology, Volume 178, Issue 4, Page e310-e310, April 2018.


https://ift.tt/2Hjh66h

The Garment Protection Factor: further advances in labelling sun‐protective clothing

British Journal of Dermatology, Volume 178, Issue 4, Page 835-836, April 2018.


https://ift.tt/2HR3kZX

对于患有光化性角化病的器官移植受者来说,光动力疗法比咪喹莫特更加有效:一项随机个体对照试验

British Journal of Dermatology, Volume 178, Issue 4, Page e313-e313, April 2018.


https://ift.tt/2HiUQtu

Defining the psychological comorbidity in vitiligo: systematically casting the net wide

British Journal of Dermatology, Volume 178, Issue 4, Page 826-826, April 2018.


https://ift.tt/2HTeb5A

Stress and skin disease quality of life: the moderating role of anxiety sensitivity social concerns

British Journal of Dermatology, Volume 178, Issue 4, Page e304-e304, April 2018.


https://ift.tt/2F7powl

HLA‐C*06 and psoriasis: susceptibility, phenotype, course and response to treatment

British Journal of Dermatology, Volume 178, Issue 4, Page 825-825, April 2018.


https://ift.tt/2HU5yaI

Pseudochylothorax Combined with Spontaneous Pneumothorax: Case Report of a Rare Complication of Rheumatoid Arthritis

Pleural involvement is the most frequent thoracic complication of rheumatoid arthritis (RA), usually occurring in patients with known RA. Typical rheumatoid pleural effusion is an exudate characterized by low pH and glucose levels and high LDH activity. Rarely, it has features of pseudochylothorax. Other uncommon complications are pneumothorax, hydropneumothorax, empyema, and bronchopleural fistula. The case of a 51-year-old man with a spontaneous, small, and asymptomatic hydropneumothorax with features of pseudochylothorax is presented. After careful clinical and laboratory evaluation, he was diagnosed with rheumatoid arthritis, and we admitted that the pleural changes were secondary to the connective tissue disease. He started immunosuppressive treatment and maintained stability during follow-up, without need of specific pleural treatment. We hypothesized that the pleural nodule found on the chest computed tomography scan was related with the simultaneous occurrence of pleural effusion and pneumothorax. This is a rare presentation and complication of RA, highlighting the utility of a comprehensive clinical and laboratory evaluation and focusing on the importance of pleural rheumatoid nodules in the pathogenesis of RA pleural disease.

https://ift.tt/2HQHq9c

A Case of Invasive Sinonasal Carcinosarcoma: The Importance of Early Detection

Sinonasal carcinosarcomas represent rare neoplasms, with aggressive character and unfavourable prognosis. We present a case of extensive sinonasal carcinosarcoma extending into the anterior cranial fossa and into the orbit and also a review of the current international literature regarding this rare yet aggressive neoplasm. There is currently a lack of specific guidelines on the optimal management of sinonasal carcinosarcoma and the treatment represents a challenge for the clinician. The key message that we would like to disseminate to our colleagues is the importance of suspicion and early detection, as well as the necessity to adopt a holistic approach when counselling patients.

https://ift.tt/2qOCkmn