Quantification of Shunt Volume Through Ventricular Septal Defect by Real-Time 3-D Color Doppler Echocardiography: An in Vitro Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Publication date: Available online 2 February 2016 Source:Ultrasound in Medicine & Biology Author(s): Meihua Zhu, Muhammad Ashraf, Lydia Tam, Cole Streiff, Sumito Kimura, Eriko Shimada, David J. Sahn Quantification of shunt volume is important for ventricular septal defects (VSDs). The aim of the in vitro study described here was to test the feasibility of using […]
The genomic landscape of cutaneous melanoma
The genomic landscape of cutaneous melanoma: Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer ...περισσότερα »
Caffeine Consumption in Subjects Undergoing Evaluation for Sleep Disordered Breathing
Evaluation of Caffeine Consumption in Subjects Undergoing Evaluation for Sleep Disordered Breathing: Journal of Caffeine Research , Vol. 0, No. 0. Author information Krishna Bajee Sriram, MBBS, FRACP, PhD1,2 and Kevin Sampang, BSc, MD2 1Department of Respiratory Medicine, Gold Coast University Hospital, Southport, Australia. 2School of Medicine, Griffith University, Southport, Australia. Address correspondence to: *Krishna Bajee Sriram, MBBS, FRACP, PhD* *Department of Respiratory Medicine* *Gold Coast University Hospital* *1 Hospital Boulevard* *Southport, QLD 4215* Australia *E-mail...περισσότερα »
Dynamics of a haemodynamic headache: A case report and literature review of headache secondary to flow inversion of the internal jugular vein
Dynamics of a haemodynamic headache: A case report and literature review of headache secondary to flow inversion of the internal jugular vein: Background Haemodialysis arteriovenous fistulas have common local and regional complications, but are rarely associated with neurological symptoms. Case report A 43-year-old woman presented with short acute episodes of unilateral, non-throbbing, severe headache, vertigo and left lateropulsion. She had undergone renal transplantation and had a still-functioning left brachial arteriovenous fistula. No abnormality was detected on neurological ... περισσότερα »
Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients
Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients: Background: Structural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear. Methods: Prospective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were assessed. Participants underwent a diffusion-tensor MRI to establish the integrity of white ... περισσότερα »
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?: Introduction Tolosa–Hunt syndrome (THS) is one of the most common ‘benign’ causes of painful ophthalmoplegia. Diagnosis is based on clinical and imaging findings and the exclusion of other causes because there is no specific biomarker for the syndrome. Eales disease, an idiopathic inflammatory venous disease that primarily affects the eye, can also affect the central (as stroke or myelitis) and peripheral nervous system. Case report We report the case of a 32-year-old woman with a subacute le... περισσότερα »
Stretching of Active Muscle Elicits Chronic Changes in Multiple Strain Risk Factors.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Introduction: The muscle stretch intensity imposed during ‘flexibility’ training influences the magnitude of joint range of motion (ROM) adaptation. Thus, stretching whilst the muscle is voluntarily activated was hypothesized to provide a greater stimulus than passive stretching. The effect of a 6-week program of stretch imposed on an isometrically-contracting muscle (i.e. qualitatively similar to isokinetic […]
The Effect of Diet or Exercise on Visceral Adipose Tissue in Overweight Youth.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Objective: Excess visceral adipose tissue (VAT) in children with obesity is associated with development of cardiovascular and metabolic disease. This meta-analysis investigated if lifestyle interventions can reduce VAT in overweight and obese youth. Methods: Pubmed, Cochrane and PEDro were searched for clinical trials that objectively assessed VAT and included study arms with supervised diet, exercise […]
Do the Threshold Limit Values for Work in Hot Conditions Adequately Protect Workers?.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
PURPOSE: We evaluated core temperature responses and the change in body heat content ([INCREMENT]Hb) during work performed according to the Threshold Limit Values (TLVs), which are designed to ensure a stable core temperature that does not exceed 38.0[degrees]C. METHODS: Nine young males performed a 120-min work protocol consisting of cycling at a fixed rate of […]
Upper airway obstruction due to a change in altitude: first report in fifty years
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Air travel mostly causes minor ear, nose and throat complaints. We describe a second report in literature of airway obstruction caused by a drop in atmospheric pressure during a routine commercial flight. Case presentation A 54-year-old male was referred to a head and neck surgeon with a 2 cm left submandibular mass that […]
The binary matroids whose only odd circuits are triangles
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Publication date: May 2016 Source:Advances in Applied Mathematics, Volume 76 Author(s): James Oxley, Kristen Wetzler This paper generalizes a graph-theoretical result of Maffray to binary matroids. In particular, we prove that a connected simple binary matroid M has no odd circuits other than triangles if and only if M is affine, M is M(K4) or […]
Combination therapies in oncology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 81 (2016). doi:10.1038/nrd.2016.3 Author: Rachel M. Webster This analysis presents anticancer drug combinations that contain two or more targeted agents and discusses their impact on oncology markets. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PU5qtd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
2015 FDA drug approvals
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 73 (2016). doi:10.1038/nrd.2016.15 Author: Asher Mullard FDA approval rate continues to surge, with 45 green lights for new drugs granted in 2015. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nG1LSN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Deal watch: Biopharma deal-making in 2015: changing the pharma landscape
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 78 (2016). doi:10.1038/nrd.2016.10 Authors: Amanda Micklus & Steven Muntner Biopharma deal-making in 2015 featured substantial consolidation and bigger transaction values than ever. Similar to 2014 (Nat. Rev. Drug Discov.14, 84–85; 2015), immuno-oncology was one of the key drivers behind partnerships, and deals aimed at treating diabetes also had high values. […]
EMA recommended 39 new drug approvals last year
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 77 (2016). doi:10.1038/nrd.2016.16 Author: Asher Mullard The European Medicines Agency (EMA) recommended the approval of 39 new therapeutics in 2015, in line with 40 product recommendations in 2014 and up from 34 recommendations in 2013.The EMA’s approval cohort includes small molecules, antibodies, blood products and vaccines. The FDA’s Center for […]
Fragile X drug development flounders
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 77 (2016). doi:10.1038/nrd.2016.18 Author: Asher Mullard Novartis has published the results of two Phase II trials of its metabotropic glutamate receptor 5 (mGluR5) inhibitor mavoglurant in Fragile X syndrome (FXS), 2 years after discontinuing development of the drug. Two Phase II trials — one in 175 adults and one in […]
Voice Before and After Endoscopic Partial Laryngectomy
Acoustic Characteristics of Voice Before and After Endoscopic Partial Laryngectomy in Early Glottic Cancer via Voice Publication date: Available online 2 February 2016 *Source:*Journal of Voice Author(s): Chanticha Chotigavanich, Jayme R. Dowdall, Ramon A. Franco ObjectivesTo evaluate the voice changes after narrow-margin endoscopic partial laryngectomy in subjects with T1N0M0 glottic cancer.Study DesignUncontrolled retrospective comparison of preoperative and postoperative mean phonation time; fundamental frequency, jitter, shimmer, and noise-to-harmonic ratio; and voice-related quali...περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Sub-clonality for BRAF mutati... περισσότερα »
Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury
Clinical and Electromyographic Characteristics of Unilateral Vocal Fold Paralysis With Lower Cranial Nerve Injury via Voice Publication date: Available online 1 February 2016 *Source:*Journal of Voice Author(s): Rong Hu, Yun Li, Wen Xu, Liyu Cheng, Hui Ren ObjectivesThe aim was to investigate the clinical and electromyographic characteristics of patients with unilateral vocal fold paralysis (UVFP) combined with lower cranial nerve injury.Study designThis is a case series with chart review.MethodsAmong 368 patients with idiopathic UVFP, 31 patients (8.4%) were eventually diagnosed with ...περισσότερα »
Does Tonsillectomy Affect Voice in Early or Late Postoperative Periods in Adults?
Does Tonsillectomy Affect Voice in Early or Late Postoperative Periods in Adults? via Voice Publication date: Available online 1 February 2016 *Source:*Journal of Voice Author(s): Doğan Atan, Emre Apaydın, Kürşat Murat Özcan, Aykut İkincioğulları, Mehmet Ali Çetin, Hüseyin Dere ObjectiveThe aim of our study was to investigate the short- and long-term effects of tonsillectomy on voice performance in adults.Study designProspective cohort study.Materials and methodsThis study was conducted between January 2013 and June 2015. A total of 26 adults who had tonsillectomy due to chronic tonsi... περισσότερα »
Perceptual Detection of Subtle Dysphonic Traits in Individuals with Cervical Spinal Cord Injury
Perceptual Detection of Subtle Dysphonic Traits in Individuals with Cervical Spinal Cord Injury Using an Audience Response Systems Approach via Voice Publication date: Available online 2 February 2016 *Source:*Journal of Voice Author(s): Kerstin Johansson, Sofia Strömbergsson, Camille Robieux, Anita McAllister ObjectivesReduced respiratory function following lower cervical spinal cord injuries (CSCIs) may indirectly result in vocal dysfunction. Although self-reports indicate voice change and limitations following CSCI, earlier efforts using global perceptual ratings to distinguish spea... περισσότερα »
Perceptual Detection of Subtle Dysphonic Traits in Individuals with Cervical Spinal Cord Injury Using an Audience Response Systems Approach
Perceptual Detection of Subtle Dysphonic Traits in Individuals with Cervical Spinal Cord Injury Using an Audience Response Systems Approach: Reduced respiratory function following lower cervical spinal cord injuries (CSCIs) may indirectly result in vocal dysfunction. Although self-reports indicate voice change and limitations following CSCI, earlier efforts using global perceptual ratings to distinguish speakers with CSCI from noninjured speakers have not been very successful. We investigate the use of an audience response system-based approach to distinguish speakers with CSCI from... περισσότερα »
An iOS-based Cepstral Peak Prominence Application: Feasibility for Patient Practice of Resonant Voice
An iOS-based Cepstral Peak Prominence Application: Feasibility for Patient Practice of Resonant Voice: Patients participating in voice therapy often express difficulty replicating therapy targets during their independent home practice. To assist patients, an iOS-based app was developed that calculates and displays cepstral peak prominence (CPP) values for patient self-monitoring of voice quality. The purpose of this study was to investigate the usability (ie ease of use) and utility (ie helpfulness) of this app in patient practice of resonant voice, and its effect on self-efficacy f... περισσότερα »
Orbital Floor Reconstruction Using a Tensor Fascia Lata Sling
After Total Maxillectomy via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 1 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Bok Ki Jung, In Sik Yun, Won Jai Lee, Dae Hyun Lew, Eun Chang Choi, Dong Won Lee PurposeReconstruction after total maxillectomy with extensive orbital floor defects poses a significant challenge for the reconstruction. The aim of this study is to present the outcomes of orbital floor reconstruction using tensor fascia lata slings after total maxillectomy and to compare these result... περισσότερα »
Genetically defined autoinflammatory diseases
Genetically defined autoinflammatory diseases: Abstract Autoinflammatory diseases are hyperinflammatory, immune-dysregulatory conditions that typically present in early childhood with fever and rashes and disease-specific patterns of organ inflammation. This review provides a historic background of autoinflammatory disease research, an overview of the currently genetically defined autoinflammatory diseases, and insights into treatment strategies derived from understanding of the disease pathogenesis. The integrative assessment of autoinflammatory conditions led to the identificatio... περισσότερα »
Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods
Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods: Abstract ObjectivesThe objective of the current study was to examine whether the nanoindentation parameters can assess the alteration of bone quality resulting from different degrees of bone remodeling between bone tissue ages around the dental implant interface with different treatments and healing periods. Materials and methodsDental implants were placed in mandibles of six male dogs. Treatment groups included: resorbable blast media-treated titanium (Ti) im... περισσότερα »
Validation of a simulator for temporomandibular joint arthroscopy
Validation of a simulator for temporomandibular joint arthroscopy: The traditional method of surgical training has followed the ‘observe, practice, and teach’ model, which is useful for open surgery, but is insufficient for minimally invasive surgery. This study presents the validation of a new simulator designed for TMJ arthroscopy training. A group of 10 senior maxillofacial surgeons performed an arthroscopy procedure using the simulator. They then completed a questionnaire analyzing the realism of the simulator, its utility, and the educational quality of the audiovisual software... περισσότερα »
Comparison of ultrasonography with conventional radiography in the diagnosis of zygomatic complex fractures
Comparison of ultrasonography with conventional radiography in the diagnosis of zygomatic complex fractures: Zygomatic complex fractures have changed in patterns of occurrence, severity, and, more importantly, in the mode of injury. Protection of the globe and maintaining the width of the face are the more important roles of the complex. Diagnosis and treatment planning of such fractures become imperative in the sequencing of repair if and where indicated, especially in the case of isolated zygomatic complex fractures. Exploring the versatility of ultrasonography (US), in diagnosing ... περισσότερα »
Cranio-Maxillo-Facial Surgery
Will Unilateral Temporomandibular Joint Anterior Disc Displacement in Teenagers Lead to Asymmetry of Condyle and Mandible? A Longitudinal Study To evaluate the change of morphological symmetry of the temporomandibular joints (TMJ) during natural course of unilateral juvenile anterior disc displacement (UJADD) by comparing the ipsilateral joint with the contralateral side; and to analyse its effect over mandibular asymmetry (MA). Investigation of the calcification at the petroclival region through Multi-slice Computed Tomography of the skull base The aim of this paper was a retrospecti...περισσότερα »
Sentinel node biopsy versus elective neck dissection. Which is more cost-effective? A prospective observational study
Sentinel node biopsy versus elective neck dissection. Which is more cost-effective? A prospective observational study: The aim of this prospective not randomized observational study was to determine the costs and outcomes of sentinel lymph node biopsy (SNB) vs elective neck dissection (END) among patients with early oral squamous cell carcinoma (OSCC). AbstractObjective The aim of this prospective not randomized observational study was to determine the costs and outcomes of sentinel lymph node biopsy (SNB) vs elective neck dissection (END) among patients with early oral squamous ...περισσότερα »
Superficial mucoceles at surgical mucosal margins of excised oral cancer specimens: An unexpected finding
Superficial mucoceles at surgical mucosal margins of excised oral cancer specimens: An unexpected finding: We read with a great interest the article by Keshet et al. [1] on ‘Superficial oral mucocele in cancer patient after radiation therapy: an overlooked yet imperative phenomenon’. We take this opportunity to share our experience of histopathological interpretation of surgical margins in oral squamous cell carcinoma (OSCC) specimens and occurrence of superficial mucocele.
Coronoid process and residual ankylotic mass as an autograft in the management of ankylosis of the temporomandibular joint in young adolescent patients: a retrospective clinical investigation
Coronoid process and residual ankylotic mass as an autograft in the management of ankylosis of the temporomandibular joint in young adolescent patients: a retrospective clinical investigation: The aim of this non-randomised investigation was to assess the feasibility of using autogenous grafts (such as coronoid process and the resected ankylotic mass) in reconstruction of the condyle after gap arthroplasty for ankylosis of the temporomandibular joint (TMJ). Sixteen patients (23 joints) operated on between 2007 and 2009 were studied and postoperative measurements of maximum interinci...περισσότερα »
Tissue microarray use for immunohistochemical study of ameloblastoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Tissue microarray use for immunohistochemical study of ameloblastoma: Background Ameloblastoma is a locally aggressive odontogenic tumor with high rates of recurrence. To better understand the molecular basis of ameloblastoma, tissue microarray (TMA) may represent a useful tool. However, despite TMA has been considered a high-throughput technique for different human neoplasms, it remains to be validated in the ameloblastoma context. Therefore, the objective of this study was to validate TMA for immunohistochemical study of ameloblastoma, determining its most appropriate design. Met... περισσότερα »
Single or multi-fractionated stereotactic radiosurgery for jugular paragangliomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Initial radiographic tumor control is similar following single or multi-fractionated stereotactic radiosurgery for jugular paragangliomas via American Journal of Otolaryngology Publication date: Available online 2 February 2016 *Source:*American Journal of Otolaryngology Author(s): Daniel Schuster, Alex D. Sweeney, Mark J. Stavas, Kyrollos Y. Tawfik, Albert Attia, Anthony J. Cmelak, George B. Wanna ObjectiveTo evaluate radiographic tumor control and treatment-related toxicity in glomus jugulare tumors treated with stereotactic radiosurgery (SRS).Study DesignRetrospective chart review.Se... περισσότερα »
Assessment of the Efficacy of Submental Intubation in the Management of Midfacial and Panfacial Trauma Patients
Assessment of the Efficacy of Submental Intubation in the Management of Midfacial and Panfacial Trauma Patients [ΑΝΑΦΟΡΑ] *Management *of *panfacial injuries*: bottom up or top down R Burnham - … Concepts in Oral and Maxillofacial Surgery: …, 2016 - Oxford University Press Σχετικά άρθρα Όλες οι 2 εκδοχές Παράθεση Αποθήκευση [HTML] από asahq.org [HTML] *Management *of the *Traumatized *Airway U Jain, M McCunn, CE Smith… - The Journal of the …, 2016 - monitor.pubs.asahq.org *...* commonly divided into three distinct zones, which facilitates initial assessment and *management* based on ... περισσότερα »
Anesthetic Efficacy of 4 % Articaine by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques
Anesthetic Efficacy of 4 % Articaine During Extraction of the Mandibular Posterior Teeth by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques: Abstract IntroductionThe study was designed to evaluate the anesthetic efficacy of 4 % articaine with 1:100,000 epinephrine (A100) in infiltration and inferior alveolar nerve block (IANB) anesthetic techniques for the pain control during extraction of the mandibular posterior teeth. MethodsThis prospective randomized single-blind clinical trial included 100 patients needing extraction of at least two mandibular molar... περισσότερα »
Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq
Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq: Mammalian odor reception is achieved by highly specialized olfactory sensory neurons (OSNs) located in the nasal cavity. Despite their importance for the daily survival of most mammals, the gene expression and regulatory profiles of these single neurons are poorly understood. Here, we report the isolation of individual GFP-labeled OSNs from *Olfr73-GFP* mice at different developmental stages followed by Next Generation Sequencing, thereby analyzing the detailed transcriptome for...περισσότερα »
A retrospective study of long-term treatment outcomes for reduced vocal intensity in hypokinetic dysarthria
A retrospective study of long-term treatment outcomes for reduced vocal intensity in hypokinetic dysarthria: Abstract BackgroundReduced vocal intensity is a core impairment of hypokinetic dysarthria in Parkinson’s disease (PD). Speech treatments have been developed to rehabilitate the vocal subsystems underlying this impairment. Intensive treatment programs requiring high-intensity voice and speech exercises with clinician-guided prompting and feedback have been established as effective for improving vocal function. Less is known, however, regarding long-term outcomes of clinical ...περισσότερα »
Efficacy of Trans-tympanic Injections of a Sodium Thiosulfate Gel to Prevent Cisplatin-induced Ototoxicity
Efficacy of Trans-tympanic Injections of a Sodium Thiosulfate Gel to Prevent Cisplatin-induced Ototoxicity: *Conditions*: DDP; Head and Neck Cancer; Adverse Effect *Intervention*: Drug: Trans-tympanic injection of a sodium thiosulfate gel *Sponsor*: Centre Hospitalier Universitaire de Québec, CHU de Québec This study evaluates whether a gel containing sodium thiosulfate deposited via a trans-tympanic injection on the round window of the middle ear could reduce the ototoxicity caused by the drug Cisplatin among patients with head and neck cancer treated by chemoradiation....περισσότερα »
Abducens ocular neuromyotonia as a delayed complication of oropharyngeal carcinoma treated with radiation
Abducens ocular neuromyotonia as a delayed complication of oropharyngeal carcinoma treated with radiation: Abstract Background Ocular neuromyotonia (ONM) is a disorder characterized by periodic involuntary extraocular muscle contraction that occurs almost exclusively in the setting of prior radiation to the sella or skull base. We present the first case of abducens neuromyotonia associated with oropharyngeal carcinoma. Methods and Results We report a case of a 63-year-old patient with abducens ONM occurring 16 years after radiation treatment for oropharyngeal squamous cell carcinoma...περισσότερα »
Indications, reconstructive techniques, and results for total glossectomy
Indications, reconstructive techniques, and results for total glossectomy: Abstract Background The best treatment for advanced tongue tumors remains controversial. Total glossectomy with laryngeal preservation is considered a feasible option, despite its morbidity. Methods A retrospective analysis of 12 total glossectomies with laryngeal preservation was performed in order to assess the available reconstruction techniques and analyze survival and functional outcomes. Results One-year overall survival (OS) and disease-free survival (DFS) rates were 58.3% and 33.3%, respectively, both ...περισσότερα »
International Journal of Pediatric Otorhinolaryngology
Paediatric diagnostic audiology testing in South Africa Publication date: March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 82 Author(s): Selvarani Moodley Introduction With the increased emphasis on the importance of early identification of paediatric hearing loss within developing countries such as South Africa and Nigeria there has been a recognition of the ethical obligation to ensure access to timely diagnostic and intervention services for children identified with hearing loss; regardless of their geographic or socioeconomic status. There are li... περισσότερα »
Safety Study of Musculoskeletal Ultrasonographic to Assess Disabilities Arm of Head and Neck Cancer Patient
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Safety Study of Musculoskeletal Ultrasonographic to Assess Disabilities Arm of Head and Neck Cancer Patient: *Condition*: Head and Neck Cancer *Intervention*: Other: ultrasonography and elastography *Sponsor*: Chang Gung Memorial Hospital The investigators suppose: 1. SND may cause damage to the soft tissue around shoulder girdle. 2. The soft tissue injury may be related with the order of severity of wing scapula and duration after SND. The aims of this study are: 1. To assess the functional disabilities of shoulder and upper extremity in different time period after SND. 2. ...περισσότερα »
Feasibility Study of Ketamine for Preventing Depression in Patients Undergoing Treatment for Head and Neck Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Feasibility Study of Ketamine for Preventing Depression in Patients Undergoing Treatment for Head and Neck Cancer: *Conditions*: Head and Neck Cancer; Depression *Interventions*: Drug: Ketamine; Other: Placebo *Sponsor*: Cedars-Sinai Medical Center The primary purpose of this study is to see if it is safe to give patients with head and neck cancer a low dose of the FDA approved anesthetic drug ketamine at the same time they receive radiation, chemotherapy, and/or surgery for their cancer treatment to prevent depression and its effects. Researchers would also like to see... περισσότερα »
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area: Clinical and pathological characteristics of incidental papillary thyroid microcancer cases, surgical, medical, and nuclear treatment methods, and patients’ outcome were studied during follow-up period of 102 months. We studied 37 patients with incidental papillary thyroid microcancer (I-PTM). The surgical procedure was total thyroidectomy in 29 and hemithyroidectomy in 8 patients. Size, multifocality, and bilateralism of PTM foci, thyroid capsule invasion, and presence of lymphovascular invasion were histopathol... περισσότερα »
Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection: Abstract Background The purpose of this study was to determine the incidence, risk factors, and prognostic significance of level VI lymph node metastases from hypopharyngeal squamous cell carcinoma (SCC). Methods A retrospective review of 68 previously untreated patients with hypopharyngeal SCC who underwent level VI node dissection was performed. Results Level VI lymph node metastases occurred in 27.9% of patients. The occult metastasis rate of level VI node... περισσότερα »
The Goose and the Gander.
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/208nmj7 via IFTTT
Ketamine Versus Special K: A Double-Edged Sword.
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1TCDLN9 via IFTTT
The Role of Ketamine in Low- and Middle-Income Countries: What Would Happen if Ketamine Becomes a Scheduled Drug?.
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/208nm2K via IFTTT
Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.
BACKGROUND: Diagnostic and interventional procedures are often facilitated by moderate procedure-related sedation. Many studies support the overall safety of this sedation; however, adverse cardiovascular and respiratory events are reported in up to 70% of these procedures, more frequently in very young, very old, or sicker patients. Monitoring with pulse oximetry may underreport hypoventilation during sedation, particularly if supplemental oxygen is provided. Capnometry may result in false alarms during sedation when patients mouth breathe or displace sampling devices. Advanced mon... περισσότερα »
Attenuation of High-Frequency (50-200 Hz) Thalamocortical Electroencephalographic Rhythms by Isoflurane in Rats Is More Pronounced for the Thalamus than for the Cortex.
BACKGROUND: Thalamocortical electroencephalographic rhythms in gamma (30-80 Hz) and high-gamma (80-200 Hz) ranges have been linked to arousal and conscious processes. We have recently shown that propofol causes a concentration-dependent attenuation of the power of thalamocortical rhythms in the 50 to 200 Hz range and that this effect is far more pronounced for the thalamus. To determine whether similar attenuation occurs with other anesthetics, we characterized the concentration-effect relationship of the inhaled anesthetic isoflurane on the spectral power of these rhythms. METHODS:... περισσότερα »
Fast Versus Slow Recruitment Maneuver at Different Degrees of Acute Lung Inflammation Induced by Experimental Sepsis.
BACKGROUND: Large tidal volume (VT) breaths or "recruitment maneuvers" (RMs) are used commonly to open collapsed lungs, but their effectiveness may depend on how the RM is delivered. We hypothesized that a stepped approach to RM delivery ("slow" RM) compared with a nonstepped ("fast" RM), when followed by decremental positive end-expiratory pressure (PEEP) titration to lowest dynamic elastance, would (1) yield a more homogeneous inflation of the lungs, thus reducing the PEEP obtained during post-RM titration; (2) produce less lung morphofunctional injury, regardless of the severity ... περισσότερα »
Human epidermal growth factor receptor 3 in head and neck squamous cell carcinomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Human epidermal growth factor receptor 3 in head and neck squamous cell carcinomas: ABSTRACT Human epidermal growth factor receptor 3 (HER3) is a member of the human epidermal growth factor receptor (HER) family. The main characteristic of HER3 is that it does not possess tyrosine kinase activity, unlike other HERs. The role of HER3 in tumorigenesis has now been recognized, particularly in head and neck squamous cell carcinomas (HNSCCs). Despite conflicting studies, HER3 was found to be overexpressed in HNSCC samples, and correlates with disease progression and poor survival, espec... περισσότερα »
Sinonasal and Anterior Skull Base Malignancies
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Low-Grade Epithelial Proliferations of the Sinonasal Tract Low-Grade Epithelial Proliferations of the Sinonasal Tract: AbstractLow-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are div...περισσότερα »
Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma: AbstractThe incidence of head and neck squamous cell carcinomas is still growing, and the long-term prognosis of advanced disease remains poor. Only a fraction of head and neck cancers are sensitive to the EGFR-inhibitor cetuximab, which is the only registered targeted therapy available today. In several cancers, gene copy number alterations of MET and PIK3CA have been found to be prognostic and predictive for therapy response. The aim of this study was to systematically a... περισσότερα »
Archives of Oral Biology
Effect of Jagged-1 and Dll-1 on osteogenic differentiation by stem cells from human exfoliated deciduous teeth Publication date: May 2016 *Source:*Archives of Oral Biology, Volume 65 Author(s): Waleerat Sukarawan, Karnnapas Peetiakarawach, Prasit Pavasant, Thanaphum Osathanon Objective The aim of the present study was to determine the influence of Notch ligands, Jagged-1 and Dll-1, on osteogenic differentiation by stem cells from human exfoliated deciduous teeth. Design Notch ligands were immobilized on tissue culture surface using an indirect affinity immobilization technique. Cell...περισσότερα »
Benzoate Allergy in Children—From Foods to Personal Hygiene Products
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
Abstract Benzoate allergy may be an overlooked allergen in children and one that may be of increasing importance with its increasing role as a preservative in pediatric personal hygiene formulations. The cases herein report an association with cola and benzoate allergy and discusses the implications of replacement of formaldehyde by benzoates in personal hygiene products. […]
The Goose and the Gander.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/208nmj7 via IFTTT
Ketamine Versus Special K: A Double-Edged Sword.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TCDLN9 via IFTTT
The Role of Ketamine in Low- and Middle-Income Countries: What Would Happen if Ketamine Becomes a Scheduled Drug?.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/208nm2K via IFTTT
Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
BACKGROUND: Diagnostic and interventional procedures are often facilitated by moderate procedure-related sedation. Many studies support the overall safety of this sedation; however, adverse cardiovascular and respiratory events are reported in up to 70% of these procedures, more frequently in very young, very old, or sicker patients. Monitoring with pulse oximetry may underreport hypoventilation during sedation, […]
Attenuation of High-Frequency (50-200 Hz) Thalamocortical Electroencephalographic Rhythms by Isoflurane in Rats Is More Pronounced for the Thalamus than for the Cortex.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
BACKGROUND: Thalamocortical electroencephalographic rhythms in gamma (30-80 Hz) and high-gamma (80-200 Hz) ranges have been linked to arousal and conscious processes. We have recently shown that propofol causes a concentration-dependent attenuation of the power of thalamocortical rhythms in the 50 to 200 Hz range and that this effect is far more pronounced for the thalamus. […]
Fast Versus Slow Recruitment Maneuver at Different Degrees of Acute Lung Inflammation Induced by Experimental Sepsis.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
BACKGROUND: Large tidal volume (VT) breaths or «recruitment maneuvers» (RMs) are used commonly to open collapsed lungs, but their effectiveness may depend on how the RM is delivered. We hypothesized that a stepped approach to RM delivery («slow» RM) compared with a nonstepped («fast» RM), when followed by decremental positive end-expiratory pressure (PEEP) titration to […]
Updates on the risk factors for latent tuberculosis reactivation and their managements
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
Updates on the risk factors for latent tuberculosis reactivation and their managements Emerging Microbes & Infections 5, e10 (February 2016). doi:10.1038/emi.2016.10 Authors: Jing-Wen Ai, Qiao-Ling Ruan, Qi-Hui Liu & Wen-Hong Zhang from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Pz0Puc via IFTTT
Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 27 δευτερόλεπτα
Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC Emerging Microbes & Infections 5, e8 (February 2016). doi:10.1038/emi.2016.8 Authors: Chandrabali Ghose, Ioannis Eugenis, Xingmin Sun, Adrianne N Edwards, Shonna M McBride, David T Pride, Ciarán P Kelly & David D Ho from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1mcjSyP via IFTTT
Climate, Vol. 4, Pages 11: Evaluation of Adaptation Practices in the Agriculture Sector of Bangladesh: An Ecosystem Based Assessment
Climate changes imposed differential impacts on Bangladesh in the form of sea level rise, extreme events, and variability, which has enormous economic, environmental and social cost. Such impacts are assorted across the ecosystems of the Southwest, Northwest and Central region of the country. Among the different sectors, agriculture is comparatively more vulnerable to climate change impacts. In order to reduce the climate change induced loss and damage, a series of adaptation options have been being practiced by the people at the local level for many years, but the effectiveness, ...περισσότερα »
Energies, Vol. 9, Pages 94: Overcoming the Fundamental Limit: Combustion of a Hydrogen-Oxygen Mixture in Micro- and Nano-Bubbles
Combustion reactions quench in small volumes due to fast heat escape via the volume boundary. Nevertheless, the reaction between hydrogen and oxygen was observed in nano- and micro-bubbles. The bubbles containing a mixture of gases were produced in microsystems using electrochemical decomposition of water with a fast switching of voltage polarity. In this paper, we review our experimental results on the reaction in micro- and nano-bubbles and provide their physical interpretation. Experiments were performed using microsystems of different designs. The process was observed with a s...περισσότερα »
IJERPH, Vol. 13, Pages 191: Residential Proximity to Major Roadways and Lung Cancer Mortality. Italy, 1990–2010: An Observational Study
Background: Air pollution from road traffic has been associated to an increased risk of lung cancer. Herein, we investigated the association between lung cancer mortality and residence near Italian highways or national major roads. Methods: Information on deaths for lung cancer registered from 1990 to 2010 and stratified by age, gender, and urban or rural municipality of residence at death were obtained from the National Institute of Statistics. Distance between the centroid of the municipality of residence and closest major roadways was considered as a proxy of pollution exposure... περισσότερα »
IJERPH, Vol. 13, Pages 189: Climate Justice in Rural Southeastern United States: A Review of Climate Change Impacts and Effects on Human Health
Climate justice is a local, national, and global movement to protect at-risk populations who are disproportionately affected by climate change. The social context for this review is the Southeastern region of the United States, which is particularly susceptible to climate change because of the geography of the area and the vulnerabilities of the inhabiting populations. Negative human health effects on variable and vulnerable populations within the Southeast region due to changing climate are concerning, as health threats are not expected to produce parallel effects among all indiv... περισσότερα »
Climate, Vol. 4, Pages 10: Long-Term Trend Analysis of Precipitation and Air Temperature for Kentucky, United States
Variation in quantities such as precipitation and temperature is often assessed by detecting and characterizing trends in available meteorological data. The objective of this study was to determine the long-term trends in annual precipitation and mean annual air temperature for the state of Kentucky. Non-parametric statistical tests were applied to homogenized and (as needed) pre-whitened annual series of precipitation and mean air temperature during 1950–2010. Significant trends in annual precipitation were detected (both positive, averaging 4.1 mm/year) for only two of the 60 pr... περισσότερα »
IJERPH, Vol. 13, Pages 187: Mapping to Support Fine Scale Epidemiological Cholera Investigations: A Case Study of Spatial Video in Haiti
The cartographic challenge in many developing world environments suffering a high disease burden is a lack of granular environmental covariates suitable for modeling disease outcomes. As a result, epidemiological questions, such as how disease diffuses at intra urban scales are extremely difficult to answer. This paper presents a novel geospatial methodology, spatial video, which can be used to collect and map environmental covariates, while also supporting field epidemiology. An example of epidemic cholera in a coastal town of Haiti is used to illustrate the potential of this new... περισσότερα »
Energies, Vol. 9, Pages 93: Quantitative Model and Metrics of Electrical Grids’ Resilience Evaluated at a Power Distribution Level
This paper presents a framework to systematically measure and assess power grids' resilience with a focus on performance as perceived by customers at the power distribution level. The proposed framework considers an analogous measure of availability as a basic metric for resilience and defines other key resilience-related concepts and metrics, such as resistance and brittleness. This framework also provides a measurement for the degree of functional dependency of loads on power grids and demonstrates how the concepts of resilience and dependency are inherently related. It also dis...περισσότερα »
Climate, Vol. 4, Pages 11: Evaluation of Adaptation Practices in the Agriculture Sector of Bangladesh: An Ecosystem Based Assessment
Climate changes imposed differential impacts on Bangladesh in the form of sea level rise, extreme events, and variability, which has enormous economic, environmental and social cost. Such impacts are assorted across the ecosystems of the Southwest, Northwest and Central region of the country. Among the different sectors, agriculture is comparatively more vulnerable to climate change impacts. In order to reduce the climate change induced loss and damage, a series of adaptation options have been being practiced by the people at the local level for many years, but the effectiveness, ...περισσότερα »
Energies, Vol. 9, Pages 94: Overcoming the Fundamental Limit: Combustion of a Hydrogen-Oxygen Mixture in Micro- and Nano-Bubbles
Combustion reactions quench in small volumes due to fast heat escape via the volume boundary. Nevertheless, the reaction between hydrogen and oxygen was observed in nano- and micro-bubbles. The bubbles containing a mixture of gases were produced in microsystems using electrochemical decomposition of water with a fast switching of voltage polarity. In this paper, we review our experimental results on the reaction in micro- and nano-bubbles and provide their physical interpretation. Experiments were performed using microsystems of different designs. The process was observed with a s...περισσότερα »
IJERPH, Vol. 13, Pages 191: Residential Proximity to Major Roadways and Lung Cancer Mortality. Italy, 1990–2010: An Observational Study
Background: Air pollution from road traffic has been associated to an increased risk of lung cancer. Herein, we investigated the association between lung cancer mortality and residence near Italian highways or national major roads. Methods: Information on deaths for lung cancer registered from 1990 to 2010 and stratified by age, gender, and urban or rural municipality of residence at death were obtained from the National Institute of Statistics. Distance between the centroid of the municipality of residence and closest major roadways was considered as a proxy of pollution exposure... περισσότερα »
IJERPH, Vol. 13, Pages 189: Climate Justice in Rural Southeastern United States: A Review of Climate Change Impacts and Effects on Human Health
Climate justice is a local, national, and global movement to protect at-risk populations who are disproportionately affected by climate change. The social context for this review is the Southeastern region of the United States, which is particularly susceptible to climate change because of the geography of the area and the vulnerabilities of the inhabiting populations. Negative human health effects on variable and vulnerable populations within the Southeast region due to changing climate are concerning, as health threats are not expected to produce parallel effects among all indiv... περισσότερα »
Climate, Vol. 4, Pages 10: Long-Term Trend Analysis of Precipitation and Air Temperature for Kentucky, United States
Variation in quantities such as precipitation and temperature is often assessed by detecting and characterizing trends in available meteorological data. The objective of this study was to determine the long-term trends in annual precipitation and mean annual air temperature for the state of Kentucky. Non-parametric statistical tests were applied to homogenized and (as needed) pre-whitened annual series of precipitation and mean air temperature during 1950–2010. Significant trends in annual precipitation were detected (both positive, averaging 4.1 mm/year) for only two of the 60 pr... περισσότερα »
Energies, Vol. 9, Pages 95: Simulation of Wind Speed in the Ventilation Tunnel for Surge Tanks in Transient Processes
Hydroelectric power plants' open-type surge tanks may be built in mountains subject to the provision of atmospheric air. Hence, a ventilation tunnel is indispensable. The air flow in the ventilation tunnel is associated with the fluctuation of water-level in the surge tank. There is a great relationship between the wind speed and the safe use and project investment of ventilation tunnels. To obtain the wind speed in a ventilation tunnel for a surge tank during transient processes, this article adopts the one-dimensional numerical simulation method and establishes a mathematical mo... περισσότερα »
An unusual giant schwannoma of cervical sympathetic chain: a case report
Background: Schwannomas are benign, well-differentiated tumors that originate from Schwann cells. Involvement of the cervical sympathetic nerve is relatively rare. Computed tomography is indispensable for the diagnosis. The treatment is surgical. Histological examination confirms the diagnosis. Horner's syndrome postoperatively is supportive of the diagnosis. The rarity of giant cervical sympathetic chain schwannoma made the case of our patient interesting to report. Furthermore, our patient's immense tumor size is very rare, and we could not find any similar report in the literat... περισσότερα »
Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report
Background: Paralysis of the external popliteal sciatic nerve is a frequent pathological condition that occurs after trauma. However, etiologies other than trauma, such as tumors, are also possible. The sensory collaterals of the external popliteal sciatic nerve have a small territory of innervation at the knee, and tumors involving these nerves become symptomatic after compression of the motor nerves. We here describe the first reported case of this phenomenon.Case presentationThis case involved a lesion compressing the origin of the external popliteal sciatic nerve of a 13-year-o... περισσότερα »
How can periorbital oedema and ecchymose be reduced in rhinoplasty? Performing a lateral osteotomy in the final stages of surgery, and subsequently applying a nasal plaster and splint as rapidly as possible, decreases PO and PE in the postoperative period.
How can periorbital oedema and ecchymose be reduced in rhinoplasty?: AbstractOedema and ecchymose are frequent morbidities of septorhinoplasty, a facial surgical procedure for reforming the shape and functions of the nose. Periorbital oedema (PO) and periorbital ecchymose (PE) are normal occurrences, but are undesirable for patients undergoing the procedure for aesthetic purposes. The present study examined 65 patients who underwent open technique septorhinoplasty for aesthetic and functional complaints. Patients were divided into two groups: Group 1 patients underwent lateral oste...περισσότερα »
Brazilian Journal of Otorhinolaryngology
Subjective visual vertical with the bucket method in Brazilian healthy individuals Publication date: Available online 2 February 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Maristela Mian Ferreira, Fabiana Cunha, Cristina Freitas Ganança, Maurício Malavasi Ganança, Heloisa Helena Caovilla Introduction The capacity of a healthy individual to estimate the true vertical in relation to the Earth when a fluorescent line is aligned in a completely dark room is called the subjective visual vertical. Objective To evaluate subjective visual vertical using the bucket meth... περισσότερα »
Subjective visual vertical with the bucket method
Original article Subjective visual vertical with the bucket method in Brazilian healthy individuals ☆ Vertical visual subjetiva com o método do balde em indivíduos brasileiros hígidos ☆ - Maristela Mian Ferreiraa, , , - Fabiana Cunhab, - Cristina Freitas Ganançac, d, - Maurício Malavasi Ganançae, - Heloisa Helena Caovillaf - a Postgraduate Program in Human Communication Disorders, Campo Fonoaudiológico, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil - b Otorhinolaryngological Sciences, Escola Paulista... περισσότερα »
The Role of Soft-Tissue Surgery of the Tongue in Obstructive Sleep Apnea
The Role of Soft-Tissue Surgery of the Tongue in Obstructive Sleep Apnea: AbstractObstructive sleep apnea is a common disease with high morbidity. Narrowing and collapse of the pharyngeal airway during sleep characterize the disease resulting in a decrease or a complete cessation of oronasal airflow. Continuous positive airway pressure is the gold standard and is proven to be very effective. However, due to its rather low adherence and acceptance, alternative treatment options for OSA are necessary. When obstruction of the upper airway (UA) is caused at the level of the tongue base... περισσότερα »
Antireflux Surgery and Laryngopharyngeal Reflux
Antireflux Surgery and Laryngopharyngeal Reflux: AbstractSurgical fundoplication, the recreation of the lower esophageal sphincter mechanism by wrapping the fundus of the stomach around the gastroesophageal junction, is a well-established treatment option in the management of gastroesophageal reflux disease. By decreasing the incidence of both acid and non-acid reflux, fundoplication results in a measureable decrease in symptoms and additional sequela of gastric reflux. Laryngopharyngeal reflux (LPR), a compliment of symptoms, resulting from the reflux of gastric contents into the ...περισσότερα »
Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea (OSA)
Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea (OSA): AbstractThe prevalence of obstructive sleep apnea (OSA), its complex pathophysiology, and the suboptimal adherence rates with positive pressure therapy, necessitate alternative treatment strategies in many OSA patients. Hypoglossal nerve stimulation (HNS) represents a novel and unique therapeutic approach that combines a surgical implant procedure with a titratable medical device to provide multilevel upper airway improvement via neuromodulation of the hypoglossal nerve. A recent multicenter prospective trial reported...περισσότερα »
The Role of Pepsin in LPR: Will It Change Our Diagnostic and Therapeutic Approach to the Disease?
The Role of Pepsin in LPR: Will It Change Our Diagnostic and Therapeutic Approach to the Disease?: AbstractLaryngopharyngeal reflux (LPR) is the back flow of gastric contents into the laryngopharynx. It is estimated that this disease affects 20−40 % of the United States population and is commonly encountered by otolaryngologists. Patients with LPR present with symptoms due to chronic laryngeal irritation such as hoarseness and cough. Pepsin, a gastric enzyme, has been shown to be a specific and sensitive biomarker for LPR. Measurement of pepsin in patients with LPR symptoms holds p... περισσότερα »
Beyond Laryngoscopy: Current Objective Diagnostic Testing and Interpretation for LPR
Beyond Laryngoscopy: Current Objective Diagnostic Testing and Interpretation for LPR: AbstractDiagnosis of laryngopharyngeal reflux (LPR) has traditionally been based on clinical symptoms and laryngoscopy findings. More recent applications of dual pH multichannel intraluminal monitoring (dual pH-MII), high-resolution esophageal manometry (HRM), and salivary pepsin testing may allow for a more comprehensive assessment of patients with suspected LPR. The limitations of empiric proton pump inhibitor (PPI) trials to establish a diagnosis of laryngeal symptoms due to LPR are evolving, a... περισσότερα »
Current Concepts in the Surgical Management of Pediatric OSA
Current Concepts in the Surgical Management of Pediatric OSA: AbstractGiven that adenotonsillar hypertrophy is a common cause of upper airway obstruction in children with obstructive sleep apnea (OSA), adenotonsillectomy (T&A) has long been the first-line management approach. Despite the positive outcomes associated with this procedure, persistent disease occurs postoperatively in 34 % of children. A number of studies have therefore used drug-induced sleep endoscopy and other methods to identify sites of upper airway obstruction that may be amenable to surgical correction. Research...περισσότερα »
Updates on the risk factors for latent tuberculosis reactivation and their managements
*Updates on the risk factors for latent tuberculosis reactivation and their managements* Emerging Microbes & Infections 5, e10 (February 2016). doi:10.1038/emi.2016.10 Authors: Jing-Wen Ai, Qiao-Ling Ruan, Qi-Hui Liu & Wen-Hong Zhang from Infection via ola Kala on Inoreader http://ift.tt/1Pz0Puc via IFTTT
1,2,3 (years) ...and your out. The End of a 123-year Historic Era.
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1SF1qvl via IFTTT
Evaluation of Xpert MTB/RIF to identify pulmonary tuberculosis in tuberculosis suspects from low and higher prevalence settings compared to acid fast smear and culture
In the US, Xpert demonstrated excellent sensitivity in AFB+ tuberculosis patients and identified the majority of AFB-, providing a rapid accurate TB diagnostic option. A single Xpert test predicted the absence of AFB+/culture positive tuberculosis in 99.7% of specimens tested, indicating a role in the respiratory isolation algorithm. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1PR2cjH via IFTTT
Videostroboscopy, Laryngopharyngeal Reflux, and Dysphonia: A Complex Relationship
Videostroboscopy, Laryngopharyngeal Reflux, and Dysphonia: A Complex Relationship: AbstractThe role of laryngoscopic examination in the diagnosis of reflux disease is controversial. Though some studies support exam findings such as laryngeal edema and erythema as supportive of a reflux diagnosis, and though many otolaryngologists continue to use these exam findings to establish a clinical diagnosis of laryngopharyngeal reflux (LPR), critical review of laryngoscopic exam has called this approach into question. The role of laryngoscopic exam as related to reflux may not be in establi... περισσότερα »
Low-Grade Epithelial Proliferations of the Sinonasal Tract
Low-Grade Epithelial Proliferations of the Sinonasal Tract: AbstractLow-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each ... περισσότερα »
An Update on Sinonasal Round Cell Undifferentiated Tumors
An Update on Sinonasal Round Cell Undifferentiated Tumors: AbstractThe sinonasal cavities host a wide variety of undifferentiated malignancies with round cell morphology, including neoplasms of epithelial, mesenchymal, neuroectodermal, and hematolymphoid lineage. The differential diagnosis may be difficult, especially in small biopsy material, due to overlapping morphology, but their correct classification is clinically relevant. The aim of this review is to provide practical guidelines for the differential diagnosis of these malignancies, with emphasis on recently described entiti...περισσότερα »
Non-infectious Inflammatory Lesions of the Sinonasal Tract
Non-infectious Inflammatory Lesions of the Sinonasal Tract: AbstractThis review covers the histopathology and pathogenesis of non-infectious inflammatory diseases of the sinonasal tract, in particular, sarcoidosis, granulomatous vasculitides Wegener, Churg–Strauss), relapsing polychondritis, eosinophilic angiocentric fibrosis, chronic rhinosinusitis and nasal perforations. Molecular associations and mechanisms are emphasised to assist pathologists to put their observations into the context of clinical, genetic and environmental influences on patients’ diseases.
Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions
Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions: AbstractSeveral benign and malignant mesenchymal and meningothelial lesions may preferentially affect or extend into the sinonasal tract. Glomangiopericytoma (GPC, formerly sinonasal-type hemangiopericytoma) is a specific tumor with a predilection to the sinonasal tract. Sinonasal tract polyps with stromal atypia (antrochoanal polyp) demonstrate unique histologic findings in the sinonasal tract. Juvenile nasopharyngeal angiofibroma (JNA) arises from specialized tissue in this location. Meningioma may d... περισσότερα »
Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus
Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus: AbstractThe sinonasal tract is one of the least frequent sites for squamous cell carcinoma in the head and neck. However, it is still a complex tumor type for pathologists because there are numerous histologic variants with unusual morphologic features, several non-squamous carcinomas in the differential diagnosis that can have similar morphology and even squamous differentiation, and because of the increasing recognition of human papillomavirus (HPV) in a... περισσότερα »
Radiologic Features of Sinonasal Tumors
Radiologic Features of Sinonasal Tumors: AbstractImaging evaluation of sinonasal tumors is most often conducted with computed tomography, which excels at identifying the effects of these masses on adjacent osseous structures, and magnetic resonance imaging that is ideal for distinguishing pathologic masses from mucosal thickening and fluid that are common in the sinonasal spaces and depicting extension into the surrounding soft tissues, orbits, and intracranial compartment. Accordingly, the two studies are complementary exams and both are commonly utilized in the assessment of thes... περισσότερα »
Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features
Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features: AbstractAdenocarcinomas of the sinonasal tract may originate from respiratory surface epithelium or the underlying seromucinous glands. These malignancies are divided into salivary-type adenocarcinomas and non-salivary-type adenocarcinomas. The latter are further divided into intestinal-type and nonintestinal-type adenocarcinomas. This review provides an update on tumor classification, differential diagnostic considerations and molecular features, as well as new adenocarcinoma entities in t... περισσότερα »
Hematolymphoid Lesions of the Sinonasal Tract
Hematolymphoid Lesions of the Sinonasal Tract: AbstractHematolymphoid neoplasms of the sinonasal tract are rare and the majority represents non-Hodgkin lymphomas. This review will focus on morphologic, immunophenotypic, and genetic characteristics of the most common types of non-Hodgkin lymphoma, namely diffuse large B cell lymphoma and extranodal natural killer/T-cell lymphoma, nasal type, but also include the discussion of less frequent other hematolymphoid entities, such as extranodal plasmacytomas and Rosai–Dorfman disease.
Endonasal Endoscopic Surgery in the Management of Sinonasal and Anterior Skull Base Malignancies
Endonasal Endoscopic Surgery in the Management of Sinonasal and Anterior Skull Base Malignancies: AbstractSinonasal malignancies represent a rare subset of tumors with a wide variety of histopathologic diagnoses and overall poor prognosis. These tumors tend to have an insidious onset with non-specific symptoms which often leads to delayed diagnosis and advanced local disease at presentation. The principal goal of surgery is to obtain a negative margin resection. Open craniofacial techniques are well established in the management of sinonasal malignancies and remain the treatment of...περισσότερα »
Newly Described Tumor Entities in Sinonasal Tract Pathology
Newly Described Tumor Entities in Sinonasal Tract Pathology: AbstractSurgical pathology of the sinonasal tract (nasal cavity and paranasal sinuses) is extremely challenging due in part to the tremendous diversity of tumor types that may arise in this region. Compounding the difficulty, a number of new sinonasal tumor entities have been recently described, and pathologists may not yet be familiar with these neoplasms. This manuscript will review the clinicopathologic features of some of the newly described sinonasal tumor types: NUT midline carcinoma, HPV-related carcinoma with aden...περισσότερα »
Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma
Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma: AbstractNeuroendocrine neoplasms (NENs) can occur in organs or tissues that do not contain neuroendocrine cells normally and do not necessarily imply embryologic derivation from the neuroectoderm; but rather reflect a shared phenotype characterized by the expression of multiple genes encoding both endocrine and neuronal features. NENs are rare in the sinonasal tract and are subdivided into epithelial and neural subtypes based on the presence of keratins or neurofilaments, respect... περισσότερα »
A retrospective study of long-term treatment outcomes for reduced vocal intensity in hypokinetic dysarthria
A retrospective study of long-term treatment outcomes for reduced vocal intensity in hypokinetic dysarthria Christopher R. WattsEmail author BMC Ear, Nose and Throat Disorders201616:2 DOI: 10.1186/s12901-016-0022-8© Watts. 2016 Received: 10 November 2015Accepted: 26 January 2016Published: 1 February 2016 Abstract Background Reduced vocal intensity is a core impairment of hypokinetic dysarthria in Parkinson’s disease (PD). Speech treatments have been developed to rehabilitate the vocal subsystems underlying this impairment. Intensive treatment programs requiring high-inte... περισσότερα »
Pro-inflammatory cytokines at zirconia implants and teeth. A cross-sectional assessment
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Abstract Objectives The aim of this study was to compare the expression of host-derived markers in peri-implant/gingival crevicular fluid (PCF/GCF) and clinical conditions at ceramic implants and contralateral natural teeth. As a secondary objective, we compared zirconia implants with titanium implants. Methods One zirconia implant (ZERAMEX® Implant System) and one contralateral natural tooth were examined […]
Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Abstract Objectives The objective of the current study was to examine whether the nanoindentation parameters can assess the alteration of bone quality resulting from different degrees of bone remodeling between bone tissue ages around the dental implant interface with different treatments and healing periods. Materials and methods Dental implants were placed in mandibles of six […]
Do chronic workplace irritant exposures cause asthma?.
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Purpose of review: The present review summarizes the recent literature on the relation between chronic workplace irritant exposures and asthma, focusing on exposures of low to moderate levels. We discuss results from epidemiological surveys, potential biological mechanisms, and needs for further research. These aspects are largely illustrated by studies on exposure to cleaning products. Recent […]
Rhinovirus-induced asthma exacerbations and risk populations.
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Purpose of review: This article discusses recent findings into the mechanisms that determine how viruses trigger asthma exacerbations. Recent findings: Substantial progress has been made in our understanding of the pathogenesis of virus-induced asthma exacerbations. This includes new insights into the role of bacteria, the regulation of interferon responses, and the discovery of innate immune […]
Table of Contents
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PfYrVN via IFTTT
Polymorphs of 4 `-(hex-5-ynyloxy)-2,2 `: 6 `,2 «-terpyridine: structural diversity arising from weak intermolecular interactions in the solid state
Changing the conditions under which 4`-(hex-5-ynyloxy)- 2,2`: 6`,2 «- terpyridine crystallises results in solvent-free crystals in which dimeric motifs supported by C&3bond; CH center dot center dot center dot N-pyridine hydrogen-bonded interactions assemble into two different 3D solid state structures. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pz1lZf via IFTTT
Drug discovery: Optimizing phenotypic screens
Nature Reviews Drug Discovery 15, 86 (2016). doi:10.1038/nrd.2016.5 Author: Sarah Crunkhorn A key challenge in designing phenotypic screens is the selection of optimal imaging biomarkers. Here, Kang et al. present a method for systematically identifying the ORACL — optimal reporter cell line for annotating compound libraries — the phenotypic profile of which most accurately classifies… Continue reading Drug discovery: Optimizing phenotypic screens
Screening: A platform for probing protein-aggregation inhibitors
Nature Reviews Drug Discovery 15, 84 (2016). doi:10.1038/nrd.2016.8 Author: Natasha Bray Several diseases are characterized by the aggregation of proteins; for example, type II diabetes is associated with the formation of human islet amyloid polypeptide (hIAPP) amyloid fibrils. One strategy to prevent such aggregation is to use small molecules that bind specifically with the protein… Continue reading Screening: A platform for probing protein-aggregation inhibitors
An unusual giant schwannoma of cervical sympathetic chain: a case report
Background: Schwannomas are benign, well-differentiated tumors that originate from Schwann cells. Involvement of the cervical sympathetic nerve is relatively rare. Computed tomography is indispensable for the diagnosis. The treatment is surgical. Histological examination confirms the diagnosis. Horner’s syndrome postoperatively is supportive of the diagnosis. The rarity of giant cervical sympathetic chain schwannoma made the case… Continue reading An unusual giant schwannoma of cervical sympathetic chain: a case report
In-strand metallated nucleic acids – novel bioinorganic constructs
Synthetic strategies have been developed for the preparation of in-chain metallated oligonucleoticles, in which the oligonucleoticle sequence is interrupted by a metal-containing motif. In our work, oligopyricline metalbinding domains are used and approaches are outlined using both labile and non-labile metal centres. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pga8M3 via IFTTT
Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report
Background: Paralysis of the external popliteal sciatic nerve is a frequent pathological condition that occurs after trauma. However, etiologies other than trauma, such as tumors, are also possible. The sensory collaterals of the external popliteal sciatic nerve have a small territory of innervation at the knee, and tumors involving these nerves become symptomatic after compression… Continue reading Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report
Huntington disease: Boosting PPARδ blocks neurodegeneration
Nature Reviews Drug Discovery 15, 83 (2016). doi:10.1038/nrd.2016.1 Author: Sarah Crunkhorn Huntington disease (HD) is a progressive autosomal-dominant neurodegenerative disorder caused by a CAG trinucleotide-repeat-expansion mutation in the huntingtin (HTT)-encoding gene. Precisely how mutant HTT results in HD pathogenesis remains unclear. Now, La Spada and colleagues reveal that mutant HTT represses peroxisome proliferator-activated receptor-δ (PPARδ)… Continue reading Huntington disease: Boosting PPARδ blocks neurodegeneration
Structural properties of methoxy derivatives of benzyl bromide, determined from powder X-ray diffraction data
Structure determination of 3,5-dimethoxybenzyl bromide and 3,4,5-trimethoxybenzyl bromide has been carried out from laboratory powder X-ray diffraction data using the direct-space Genetic Algorithm technique for structure solution followed by Rietveld refinement. These two compounds are of interest for their potential use as building blocks for the synthesis of dendritic materials. Although the two molecules differ… Continue reading Structural properties of methoxy derivatives of benzyl bromide, determined from powder X-ray diffraction data
5-Azacytidine partially restores CD20 expression in follicular lymphoma that lost CD20 expression after rituximab treatment: a case report
Background: The loss of CD20 protein expression after a rituximab-containing regimen is one of the resistance mechanisms in non-Hodgkin’s lymphoma. Recently, it was reported that 5-azacitidine administration upregulates the expression of CD20 in CD20-negative B-cell acute lymphoblastic leukemia. Here we report a similar upregulation in a patient with follicular lymphoma who was treated with 5-azacitidine… Continue reading 5-Azacytidine partially restores CD20 expression in follicular lymphoma that lost CD20 expression after rituximab treatment: a case report
Self-organized monolayers: A route to conformational switching and read-out of functional supramolecular assemblies by scanning probe methods
Self-organized molecular layers provide a promising route to constructing new (switch able) nanodevices and optimizing nanosensors. The design of such molecules involves control of structure and stabilization on the surface, as well as control of functionality. The search for a potentially universal «adapter« from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pz1kVm via IFTTT
Speech Recognition of Bimodal Cochlear Implant Recipients Using a Wireless Audio Streaming Accessory for the Telephone
[image: image]Objective: The goals of the present investigation were (1) to evaluate recognition of recorded speech presented over a mobile telephone for a group of adult bimodal cochlear implant users, and (2) to measure the potential benefits of wireless hearing assistance technology (HAT) for mobile telephone speech recognition using bimodal stimulation (i.e., a cochlear implant in one ear and a hearing aid on the other ear). Study Design: A three-by-two-way repeated measures design was used to evaluate mobile telephone sentence-recognition performance differences obtained in qui...περισσότερα »
Speech Understanding in Children With Normal Hearing: Sound Field Normative Data for BabyBio, BKB-SIN, and QuickSIN
[image: image]Objective: The primary goal was to establish normative data for the Pediatric AzBio "BabyBio," QuickSIN, and BKB-SIN measures in the sound field for children with normal hearing. Setting: Tertiary care hospital; cochlear implant (CI) program. Patients: Forty-one children with normal hearing were recruited across four age groups (5–6, 7–8, 9–10, and 11–12 yr). Interventions: Sentence recognition testing was assessed at four different signal-to-noise ratios (SNRs, +10, +5, 0, and −5 dB) for BabyBio sentences as well as for the BKB-SIN and QuickSIN tests. All measures were... περισσότερα »
Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?
[image: image]Hypothesis: In children with bilateral cochlear implants (BiCIs), experience over a 1 to 3-year period can improve speech understanding and spatial unmasking of speech. Background: One reason for providing children with BiCIs is to improve spatial hearing abilities. Little is known about changes in performance with added bilateral experience, and the relation between sound localization and spatial unmasking of speech. Methods: Twenty children with BiCIs participated. Testing was conducted typically within a year of bilateral activation, and at 1, 2, or 3 follow-up annu... περισσότερα »
Video showing how to cannulate the external jugular vein and a training video about chemical suicide response
Top 5 EMS videos of January 2016: A video showing how to cannulate the external jugular vein and a training video about chemical suicide response were among this month's top videos. *Remember 2 Things: When to use a nasopharyngeal airway* Steve Whitehead reminds us to always attempt to insert a nasopharyngeal airway when using a bag valve mask, and that it should be used in combination with other airway adjuncts. *12-lead ECG interpretation tips* This four-step technique will help you interpret your 12-lead ECGs. *How to cannulate the external jugular vein* Demonstr... περισσότερα »
Core skills for airway management
5 core skills for airway management: Learn about five requisite skills for airway management from Vanderbilt Emergency Medicine. Those skills are excellent BVM, direct laryngoscopy, video laryngoscopy, surgical airway and use of a supraglottic airway.
Validation and Establishment of an Interval-level Measure of Balance Assessment in Sitting and Standing Positions in Patients with Stroke
Publication date: Available online 2 February 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Chien-Yu Huang, Chen-Yi Song, Kuan-Lin Chen, Yi-Miau Chen, Wen-Shian Lu, I-Ping Hsueh, Ching-Lin Hsieh ObjectiveThe aims of this study were: (1) to validate the psychometric properties of the Balance Assessment in Sitting and Standing Positions (BASS), including validity (unidimensionality and concurrent validity), reliability (Rasch reliability), and responsiveness (compared with the Postural Assessment Scale for Stroke Patients, PASS), and (2) to transform the BA...περισσότερα »
Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study
Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study Adrian MendezEmail author, Hadi Seikaly, Vincent L. Biron, Lin Fu Zhu and David W. J. Côté Journal of Otolaryngology - Head & Neck Surgery201645:7 DOI: 10.1186/s40463-016-0118-6© Mendez et al. 2016 Received: 15 June 2015Accepted: 14 January 2016Published: 1 February 2016 Abstract Background Recent studies have examined the effects of brief electrical stimulation (BES) on nerve regeneration, with some suggesting that BES accelerates facial nerve recovery. Howe...περισσότερα »
Upper airway obstruction due to a change in altitude: first report in fifty years
Upper airway obstruction due to a change in altitude: first report in fifty years: Journal of Otolaryngology - Head & Neck Surgery201645:9 DOI: 10.1186/s40463-016-0121-y© Butskiy and Anderson. 2016 Received: 18 June 2015Accepted: 25 January 2016Published: 1 February 2016 Abstract Background Air travel mostly causes minor ear, nose and throat complaints. We describe a second report in literature of airway obstruction caused by a drop in atmospheric pressure during a routine commercial flight. Case presentation A 54-year-old male was referred to a head and neck surgeon with...περισσότερα »
Cochlear implant and congenital cholesteatoma
Cochlear implant and congenital cholesteatoma Abstract Background The occurence of cholesteatoma and cochlear implant is rare. Secondary cholesteatomas may develop as a result of cochlear implant surgery. Primarily acquired cholesteatoma is not typically associated with congenital sensorineural hearing loss or cochlear implant in children. The occurrence of congenital cholesteatoma during cochlear implant surgery has never been reported before, partly because all patients are preoperatively submitted to imaging studies which can theoretically exclude the disease. Case prese... περισσότερα »
Superficial mucoceles at surgical mucosal margins of excised oral cancer specimens
: An unexpected finding via ScienceDirect Publication: Oral Oncology Publication date: Available online 2 February 2016 *Source:*Oral Oncology Author(s): Gargi S. Sarode, Sachin C. Sarode [image: Photomicrograph showing cystic cavity filled with mucous material and ...]
Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours
Main ArticleSurvival outcomes after surgical resection of pulmonary metastases of head and neck tumoursS Hosokawaa1 c1, K Funaia2, K Sugiyamaa1, G Takahashia1, J Okamuraa1, Y Takizawaa1, T Yamatodania1 and H Minetaa1 a1 Department of Otorhinolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Japan a2 First Department of Surgery, Hamamatsu University School of Medicine, Japan Abstract Background: There is limited information available regarding the benefits and outcomes of resection of pulmonary metastases arising from head and neck cancers. Methods: A retrospe... περισσότερα »
Otology & Neurotology - Featured Articles
Introduction to the 14th Symposium on Cochlear Implants in Children, Nashville, TN Papers No abstract available Improving Spoken Language Outcomes for Children With Hearing Loss: Data-driven Instruction [image: image]Objective: To assess the effects of data-driven instruction (DDI) on spoken language outcomes of children with cochlear implants and hearing aids. Study Design: Retrospective, matched-pairs comparison of post-treatment speech/language data of children who did and did not receive DDI. Setting: Private, spoken-language preschool for children with hearing loss. Subjects: El...περισσότερα »
A next-generation sequencing gene panel (Miami OtoGenes) for comprehensive analysis of deafness genes
A next-generation sequencing gene panel (Miami OtoGenes) for comprehensive analysis of deafness genes via Hearing Research Publication date: Available online 2 February 2016 *Source:*Hearing Research Author(s): Demet Tekin, Denise Yan, Guney Bademci, Yong Feng, Shengru Guo, Joseph Foster, Susan Blanton, Mustafa Tekin, Xuezhong Liu Extreme genetic heterogeneity along with remarkable variation in the distribution of causative variants across in different ethnicities makes single gene testing inefficient for hearing loss. We developed a custom capture/next-generation sequencing gene panel... περισσότερα »
Computed Tomography Estimation of Cochlear Duct Length Can Predict Full Insertion in Cochlear Implantation.
Computed Tomography Estimation of Cochlear Duct Length Can Predict Full Insertion in Cochlear Implantation.: Objective: To compare the rates of full insertion of electrodes and hearing outcomes obtained with 28-mm and 31-mm cochlear implant electrode arrays. To assess whether cochlear duct length (CDL) estimated by preoperative computed tomography (CT) predicts whether an electrode is fully inserted. Study Design: A cohort study compared electrodes inserted and hearing outcomes after implantation with 28-mm or 31-mm arrays. CDL estimated from preoperative CT was compared in patients ...περισσότερα »
An unusual giant schwannoma of cervical sympathetic chain: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Background: Schwannomas are benign, well-differentiated tumors that originate from Schwann cells. Involvement of the cervical sympathetic nerve is relatively rare. Computed tomography is indispensable for the diagnosis. The treatment is surgical. Histological examination confirms the diagnosis. Horner’s syndrome postoperatively is supportive of the diagnosis. The rarity of giant cervical sympathetic chain schwannoma made the case […]
Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Background: Paralysis of the external popliteal sciatic nerve is a frequent pathological condition that occurs after trauma. However, etiologies other than trauma, such as tumors, are also possible. The sensory collaterals of the external popliteal sciatic nerve have a small territory of innervation at the knee, and tumors involving these nerves become symptomatic after compression […]
5-Azacytidine partially restores CD20 expression in follicular lymphoma that lost CD20 expression after rituximab treatment: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Background: The loss of CD20 protein expression after a rituximab-containing regimen is one of the resistance mechanisms in non-Hodgkin’s lymphoma. Recently, it was reported that 5-azacitidine administration upregulates the expression of CD20 in CD20-negative B-cell acute lymphoblastic leukemia. Here we report a similar upregulation in a patient with follicular lymphoma who was treated with 5-azacitidine […]
A novel mutation in GLUD1 causing hyperinsulinism-hyperammonemia in a patient with high density of homozygosity on microarray: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Background: Hyperinsulinism-hyperammonemia syndrome is the second most common cause of congenital hyperinsulinism and is easily treated with diazoxide; however, the symptoms in our patient were very difficult to control with typical medical therapy. To the best of our knowledge, neither our patient’s mutation, nor a case of hyperinsulinism-hyperammonemia presenting with dysmorphic features and intrauterine growth […]
Vorbereitung zur Facharztprüfung HNO
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QZkiW7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles and potential
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:Biochimica et Biophysica Acta (BBA) – Reviews on Cancer Author(s): Anna Kazanets, Tatiana Shorstova, Khalid Hilmi, Maud Marques, Michael Witcher Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However, all cancers harbor some universal aberrations. One of these is the epigenetic silencing of tumor suppressor genes […]
Apparently intrathyroid papillary thyroid carcinoma > 1 cm and ≤ 4 cm: Is the need for completion thyroidectomy common among patients submitted to lobectomy?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Many authors recommend total thyroidectomy for patients with papillary thyroid carcinoma (PTC) > 1 cm, even if the tumor is sporadic, unilateral, ≤ 4 cm, and apparently restricted to the thyroid. In the last edition of the guidelines of the British Thyroid Association (BTA), lobectomy is as accepted for the treatment of patients with PTC […]
Trauma-associated bleeding: management of massive transfusion.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Purpose of review: Early treatment goals in the bleeding trauma patient have changed based on recent research findings. Trauma patients requiring a massive transfusion protocol have shown a decreased mortality based on a more aggressive and balanced approach to blood product resuscitation. This chapter will review the recent advances in managing the bleeding trauma patient. […]
Zystische Raumforderung des Mediastinums
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Wie lautet Ihre Diagnose? Eine 53-jährige Patientin klagt über Schluckschwierigkeiten mit Schmerzausstrahlung in den Rücken beidseits bei Aufnahme von fester Nahrung, nicht aber bei flüssiger oder breiiger Kost. Des Weiteren strahlten die Schmerzen in den Oberbauch aus. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/208ky5D via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 […]
Schlechte Glatze, gute Glatze
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Haupt-Sache Krebsrisiko Die androgenetische Alopezie dient als Marker für die Exposition gegenüber virilisierenden Sexualhormonen. Diese Hormone stehen auch mit bestimmten Krebserkrankungen in Verbindung. Ist die Glatze also auch ein Marker für das Krebsrisiko? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23IraMF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Dickkopf-related Protein 3 as a Sensitive and Specific Marker for Cerebrospinal Fluid Leaks.
Dickkopf-related Protein 3 as a Sensitive and Specific Marker for Cerebrospinal Fluid Leaks.: Hypothesis: Cerebrospinal fluid (CSF) can be identified by using an enzyme-linked immunosorbent assay (ELISA) for Dickkopf-related protein 3 (DKK3). Background: Cerebrospinal fluid leakage from the subarachnoid space is a potentially alarming condition that, left unrepaired, may result in increased risk of meningitis and encephalitis. Current biochemical methods of CSF leak detection involve using beta-2-transferrin-based or beta trace protein-based assays, both of which, at present, have li... περισσότερα »
Corrigendum to ‘One-stage dual latissimus dorsi muscle flap transfer with a pair of vascular anastomoses and double nerve suturing for long-standing facial paralysis’ J Plast Reconstr Aesthet Surg 68 (2015) e113–e119
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The authors regret that the corresponding author’s name was displayed incorrectly on the original version of the article. The correct display should have been ‘Mutsumi Okazaki’, rather than ‘Okazaki Mutsumi’. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1o4xj5r via IFTTT
Oncological outcomes of lipofilling breast reconstruction: 195 consecutive cases and literature review
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Lipofilling has become a widely used procedure in breast reconstruction after mastectomy or breast-conserving treatment. The possibility that this technique may increase stimulation of cancer development between the potential tumor bed and the lipoaspirates grafts has been raised regarding its safety. The aim of this study was to identify the oncological risks associated with this […]
Title: Invited Commentary: Poly Implant Prothèse™ PIP) experience in the United Kingdom: a prospective cohort study into the accuracy of diagnostic imaging findings in comparison to operative findings of 1029 implants
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The authors have provided valuable information for readers who evaluate and treat patients with any type of silicone gel implant. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mbDPFU via IFTTT
A transverse pull-through suture technique to repair volar plate avulsion for a chronic swan neck deformity
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Proximal interphalangeal joint (PIPJ) injuries can cause significant functional disruption, attributable to chronic instability, limitation of finger flexion and swan neck deformity. These often affect young individuals, in employment. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZIIyE via IFTTT
Considerations regarding lipofilling in patients after breast cancer
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autologous fat transfer has been slowly gaining ground as a method to improve aesthetics after oncologic breast surgery. To date, few studies have been able to conclude if this increases local recurrence rates, and the margin of safety cannot be established until long-term data is available. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mbDPFO via […]
Association of occlusal interference-induced masseter muscle hyperalgesia and P2X3 receptors in the trigeminal subnucleus caudalis and midbrain periaqueductal gray.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
P2X3 receptor plays a role in nociception transmission of orofacial pain in temporomandibular disorder patients. A previous study found that P2X3 receptors in masseter muscle afferent neurons and the trigeminal ganglia were involved in masseter muscle pain induced by inflammation caused by chemical agents or eccentric muscle contraction. In this study, we attempted to investigate […]
Serum uric acid levels in patients with myasthenia gravis are inversely correlated with disability.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Uric acid (UA), the final product of purine metabolism, has been reported to be reduced in patients with various neurological disorders and is considered to be a possible indicator for monitoring the disability and progression of multiple sclerosis. However, it remains unclear whether there is a close relationship between UA and myasthenia gravis (MG), or […]
Evidence of a subcommissural organ involvement in the brain response to lead exposure and a modulatory potential of curcumin.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Substantial evidence supports the neurochemical vulnerability to lead (Pb) as one of the most potent neurotoxic heavy metals. In the present study, we aimed to assess: (i) The subcommissural organ (SCO) responsiveness as a secretory circumventricular organ to chronic and acute Pb intoxication together with its serotoninergic innervation. (ii) The possible restorative effect of curcumin […]
Trauma-associated bleeding: management of massive transfusion.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Purpose of review: Early treatment goals in the bleeding trauma patient have changed based on recent research findings. Trauma patients requiring a massive transfusion protocol have shown a decreased mortality based on a more aggressive and balanced approach to blood product resuscitation. This chapter will review the recent advances in managing the bleeding trauma patient. […]
Exploring the unknown: Electrophysiological and behavioural measures of visuospatial learning
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Visuospatial memory describes our ability to temporarily store and manipulate visual and spatial information and is employed for a wide variety of complex cognitive tasks. Here a visuospatial learning task requiring fine motor control is employed to investigate visuospatial learning in a group of typically developing adults. Electrophysiological and behavioural data is collected during […]
Immunopathology of mycobacterial diseases
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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TRP channels and traffic-related environmental pollution-induced pulmonary disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Environmental pollutant exposures are major risk factors for adverse health outcomes, with increased morbidity and mortality in humans. Diesel exhaust (DE) is one of the major harmful components of traffic-related air pollution. Exposure to DE affects several physiological systems, including the airways, and pulmonary diseases are increased in highly populated urban areas. Hence, there […]
Questionable Ethical Clearance, Incorrect Recommendations and Indiscernible Merit
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Anesthetic Efficacy of 4 % Articaine During Extraction of the Mandibular Posterior Teeth by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Introduction The study was designed to evaluate the anesthetic efficacy of 4 % articaine with 1:100,000 epinephrine (A100) in infiltration and inferior alveolar nerve block (IANB) anesthetic techniques for the pain control during extraction of the mandibular posterior teeth. Methods This prospective randomized single-blind clinical trial included 100 patients needing extraction of at least […]
Assessment of the Efficacy of Submental Intubation in the Management of Midfacial and Panfacial Trauma Patients
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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The gap-startle paradigm to assess auditory temporal processing: Bridging animal and human research
Abstract The gap-prepulse inhibition of the acoustic startle (GPIAS) paradigm is the primary test used in animal research to identify gap detection thresholds and impairment. When a silent gap is presented shortly before a loud startling stimulus, the startle reflex is inhibited and the extent of inhibition is assumed to reflect detection. Here, we applied the same paradigm in humans. One hundred and fifty-seven normal-hearing participants were tested using one of five gap durations (5, 25, 50, 100, 200 ms) in one of the following two paradigms—gap-embedded in or gap-following—the ... περισσότερα »
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?
Introduction Tolosa–Hunt syndrome (THS) is one of the most common ‘benign’ causes of painful ophthalmoplegia. Diagnosis is based on clinical and imaging findings and the exclusion of other causes because there is no specific biomarker for the syndrome. Eales disease, an idiopathic inflammatory venous disease that primarily affects the eye, can also affect the central… Continue reading Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?
Table of Contents
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Osteoarthritis in the hands of Michelangelo Buonarroti
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Rhinovirus-induced asthma exacerbations and risk populations.
Purpose of review: This article discusses recent findings into the mechanisms that determine how viruses trigger asthma exacerbations. Recent findings: Substantial progress has been made in our understanding of the pathogenesis of virus-induced asthma exacerbations. This includes new insights into the role of bacteria, the regulation of interferon responses, and the discovery of innate immune… Continue reading Rhinovirus-induced asthma exacerbations and risk populations.
Probiotics and prevention of eczema: have we enough data to draw conclusions?
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Do chronic workplace irritant exposures cause asthma?.
Purpose of review: The present review summarizes the recent literature on the relation between chronic workplace irritant exposures and asthma, focusing on exposures of low to moderate levels. We discuss results from epidemiological surveys, potential biological mechanisms, and needs for further research. These aspects are largely illustrated by studies on exposure to cleaning products. Recent… Continue reading Do chronic workplace irritant exposures cause asthma?.
Total robotic radical rectal resection with da Vinci Xi system: single docking, single phase technique
Abstract Objective This study aims to assess the advantages of Da Vinci Xi system in rectal cancer surgery. It also assesses the initial oncological outcomes after rectal resection with this system from a tertiary cancer center in India. Introduction Robotic rectal surgery has distinct advantages over laparoscopy. Total robotic resection is increasing following the evolution… Continue reading Total robotic radical rectal resection with da Vinci Xi system: single docking, single phase technique
Editorial Board
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/208dw0Q via IFTTT
Intimate Partner Firearms Violence: A Topic Ignored in Women’s Health Journals and the Impact on Health Provid ers
Violence and Gender , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Ss0YT3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UIQoEA via IFTTT
Revealed: Why the duchess was so ugly
Radiologists from Malta have shed new light on «The Ugly Duchess,» a famous… Read more on AuntMinnieEurope.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1nFTYo4 via IFTTT
Computed Tomography Estimation of Cochlear Duct Length Can Predict Full Insertion in Cochlear Implantation.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: To compare the rates of full insertion of electrodes and hearing outcomes obtained with 28-mm and 31-mm cochlear implant electrode arrays. To assess whether cochlear duct length (CDL) estimated by preoperative computed tomography (CT) predicts whether an electrode is fully inserted. Study Design: A cohort study compared electrodes inserted and hearing outcomes after implantation […]
Questionable Ethical Clearance, Incorrect Recommendations and Indiscernible Merit
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PytXBV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Anesthetic Efficacy of 4 % Articaine During Extraction of the Mandibular Posterior Teeth by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Introduction The study was designed to evaluate the anesthetic efficacy of 4 % articaine with 1:100,000 epinephrine (A100) in infiltration and inferior alveolar nerve block (IANB) anesthetic techniques for the pain control during extraction of the mandibular posterior teeth. Methods This prospective randomized single-blind clinical trial included 100 patients needing extraction of at least […]
Assessment of the Efficacy of Submental Intubation in the Management of Midfacial and Panfacial Trauma Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o4Ew5r via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Inhibition of cell proliferation, migration and invasion by a glioma-targeted fusion protein combining the p53 C terminus and MDM2-binding domain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives The aim of this study was to develop multifunctional fusion proteins for targeting and delivering therapy elements into glioma cells. Materials and methods Multifunctional fusion proteins were expressed in Escherichia coli and purified using Ni-NTA resin affinity chromatography. Human glioma cells and primary astrocytes were used to analyse their functions. Targeting proteins location […]
Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Physiological oxygen tension plays a critical role in homoeostatic maintenance and development of endochondral bone. Based on the proximity between uncalcified cartilage and subchondral bone, and microchannels that serve as a message delivery network between them, we aimed to explore the influence of low oxygen tension on soluble factor secretion in both chondrocytes […]
Overexpression of CD61 promotes hUC-MSC differentiation into male germ-like cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Previous studies have shown that germ-like cells can be induced from human umbilical cord mesenchymal stem cell (hUC-MSCs) in vitro. However, induction efficiency was low and a stable system had not been built. CD61, also called integrin-β3, plays a significant role in cell differentiation, in that CD61-positive-cell-derived pluripotent stem cells easily differentiate into […]
microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives microRNAs (miRNAs), are non-coding RNAs that regulate gene expression, and are involved in tumour development. The aim of this study was to investigate microRNA-497 (miR-497) expression and its role in development of colorectal cancer (CRC). Materials and methods RT-PCR was performed to detect expression of miR-497 in CRC cell lines (HCT8, LOVO, Ls-174, […]
Decellularized human amniotic membrane: how viable is it as a delivery system for human adipose tissue-derived stromal cells?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Human amniotic membrane (HAM) has been widely used in soft tissue engineering both in its fresh form and decellularized; its efficiency to aid treatment of burn injuries is well known. On the other hand, it has been reported clinically by several studies that human adipose-derived stem cells (hADSC) are a promising cell source […]
Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles S Hosokawa, K Funai, K Sugiyama, G Takahashi, J Okamura, Y Takizawa, T Yamatodani, H Mineta The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SXnYZS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
These new articles for Molecular Endocrinology are available online
These new articles for Molecular Endocrinology are available online ------------------------------ Early Release Molecular Endocrinology ------------------------------ [image: Molecular Endocrinology masthead] ------------------------------ ------------------------------ Molecular Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ GnRH Pulse Frequency Control of Fshb Gene Expression is Mediated via ERK1/2 Regulation of ICER Iain R. Thompson, et al. | Molecular E... περισσότερα »
Latest Article Alert from BMC Ear, Nose and Throat Disorders
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: BMC Ear, Nose and Throat Disorders] Article alert ------------------------------ The following new article has just been published in *BMC Ear, Nose and Throat Disorders* Research article A retrospective study of long-term treatment outcomes for reduced vocal intensity in hypokinetic dysarthria Watts C *BMC Ear, Nose and Throat Disorders* 2016, *16* :2 (1 February 2016) Abstract | Full text | PDF ------------------------------ You currently receive *BMC Ear, Nose and Throat Disorders* article alerts whenever new articles are published To change the email format or... περισσότερα »
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Introduction Tolosa–Hunt syndrome (THS) is one of the most common ‘benign’ causes of painful ophthalmoplegia. Diagnosis is based on clinical and imaging findings and the exclusion of other causes because there is no specific biomarker for the syndrome. Eales disease, an idiopathic inflammatory venous disease that primarily affects the eye, can also affect the central […]
Do chronic workplace irritant exposures cause asthma?.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Purpose of review: The present review summarizes the recent literature on the relation between chronic workplace irritant exposures and asthma, focusing on exposures of low to moderate levels. We discuss results from epidemiological surveys, potential biological mechanisms, and needs for further research. These aspects are largely illustrated by studies on exposure to cleaning products. Recent […]
Rhinovirus-induced asthma exacerbations and risk populations.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Purpose of review: This article discusses recent findings into the mechanisms that determine how viruses trigger asthma exacerbations. Recent findings: Substantial progress has been made in our understanding of the pathogenesis of virus-induced asthma exacerbations. This includes new insights into the role of bacteria, the regulation of interferon responses, and the discovery of innate immune […]
Albumin expression distinguishes bile duct adenomas from metastatic adenocarcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Aims Bile duct adenomas may be difficult to distinguish from metastatic carcinoma, particularly well-differentiated pancreatic ductal adenocarcinoma. Prior studies have evaluated the utility of various immunohistochemical markers, although these markers are notable for low sensitivity and/or specificity. Herein, we investigated the utility of albumin and BRAFV600E expression in distinguishing between metastatic pancreatic adenocarcinoma and […]
Intimate Partner Firearms Violence: A Topic Ignored in Women’s Health Journals and the Impact on Health Providers
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Violence and Gender , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Ss0YT3 via IFTTT
Total robotic radical rectal resection with da Vinci Xi system: single docking, single phase technique
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Objective This study aims to assess the advantages of Da Vinci Xi system in rectal cancer surgery. It also assesses the initial oncological outcomes after rectal resection with this system from a tertiary cancer center in India. Introduction Robotic rectal surgery has distinct advantages over laparoscopy. Total robotic resection is increasing following the evolution […]
Tissue microarray use for immunohistochemical study of ameloblastoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background Ameloblastoma is a locally aggressive odontogenic tumor with high rates of recurrence. To better understand the molecular basis of ameloblastoma, tissue microarray (TMA) may represent a useful tool. However, despite TMA has been considered a high-throughput technique for different human neoplasms, it remains to be validated in the ameloblastoma context. Therefore, the objective of […]
FGFR2 splice site mutations in Crouzon and Pfeiffer syndromes: two novel variants
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Barcode Sequencing Screen Identifies SUB1 as a Regulator of Yeast Pheromone Inducible Genes
The yeast pheromone response pathway serves as a valuable model of eukaryotic mitogen activated protein kinase (MAPK) pathways and transcription of their downstream targets. Here we describe application of a screening method combining two technologies, fluorescence-activated cell sorting (FACS) with Barcode analysis by Sequencing (Bar-Seq). Using this screening method, and p*FUS1*-GFP as a reporter for MAPK pathway activation, we readily identified mutants in known mating pathway components. In this study, we also include a comprehensive analysis of the *FUS1* induction properties...περισσότερα »
Utilizing Gene Tree Variation to Identify Candidate Effector Genes in Zymoseptoria tritici
*Zymoseptoria tritici* is a host-specific, necrotrophic pathogen of wheat. Infection by *Z. tritici* is characterized by its extended latent period, which typically lasts two weeks, and is followed by extensive host cell death and rapid proliferation of fungal biomass. This work characterizes the level of genomic variation in 13 isolates for which we have measured virulence on 11 wheat cultivars with differential resistance genes. Between the reference isolate, IPO323, and the 13 Australian isolates we identified over 800,000 single nucleotide polymorphisms, of which ~10% had an ef... περισσότερα »
Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis
The eastern North American monarch butterfly, *Danaus plexippus*, is an emerging model system to study the neural, molecular and genetic basis of animal long-distance migration and animal clockwork mechanisms. While genomic studies have provided new insight into migration-associated and circadian clock genes, the general lack of simple and versatile reverse-genetic methods has limited *in vivo* functional analysis of candidate genes in this species. Here, we report the establishment of highly efficient and heritable gene mutagenesis methods in the monarch butterfly using transcrip...περισσότερα »
Albumin expression distinguishes bile duct adenomas from metastatic adenocarcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Aims Bile duct adenomas may be difficult to distinguish from metastatic carcinoma, particularly well-differentiated pancreatic ductal adenocarcinoma. Prior studies have evaluated the utility of various immunohistochemical markers, although these markers are notable for low sensitivity and/or specificity. Herein, we investigated the utility of albumin and BRAFV600E expression in distinguishing between metastatic pancreatic adenocarcinoma and […]
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity. Nature Communications doi: 10.1038/ncomms10529 Authors: Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine […]
Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use ‘designer’ chromatin to show that H2B-ub orients hDot1L into the correct position for activation. Nature Communications doi: 10.1038/ncomms10589 Authors: Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel […]
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Circadian rhythms and related behaviours vary across individuals. Here, a large genome-wide association study reveals common single nucleotide variants influencing whether an individual reports as being a ‘morning person’ by identifying 15 significant loci, including 7 near known circadian genes. Nature Communications doi: 10.1038/ncomms10448 Authors: Youna Hu, Alena Shmygelska, David Tran, Nicholas Eriksson, Joyce […]
Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article LncRNAs regulate gene expression via their RNA product and through transcriptional interference. Here, Stojic et al. uncouple these functions by using multiple siRNAs against GNG12-AS1 to show that this lncRNA has a product related role in MET signaling while its transcription modulates DIRAS3 expression. Nature Communications doi: 10.1038/ncomms10406 Authors: Lovorka Stojic, Malwina Niemczyk, Arturo […]
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis following anti-CTLA-4 treatment. Nature Communications doi: 10.1038/ncomms10391 Authors: Krista Dubin, Margaret K. Callahan, Boyu Ren, Raya […]
