Komplexe Schmerztherapie: Wenn die rechte Hand nicht weiß, was die linke Hand tut
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Komplexe Schmerztherapie: Wenn die rechte Hand nicht weiß, was die linke Hand tut: ZusammenfassungAnhand eines Patientenbeispiels werden unterschiedliche Probleme in der Tumorschmerztherapie aufgezeigt, durch die eine suffiziente Schmerzeinstellung erschwert werden kann. Neben der Compliance, dem patientenseitigen Haupteinflussfaktor in diesem Fallbericht, haben strukturelle Gegebenheiten und technische Entwicklungen der letzten Jahre zunehmend an Bedeutung gewonnen. Der Weg weg von der papierenen Krankenakte hin zur Krankengeschichte in digitaler Form ist schon längst eingeschlage... περισσότερα »
Alternaria and Cladosporium in cities and relationship with the meteorological parameters
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
A 10-year study of Alternaria and Cladosporium in two Polish cities (Szczecin and Cracow) and relationship with the meteorological parameters: Abstract*Alternaria* and *Cladosporium* spores belong to the most frequent and allergenic particles in bioaerosol in the temperate climate. The investigation of *Alternaria* and *Cladosporium* spore concentrations was performed in two cities in Poland, Szczecin and Cracow, in 2004–2013. The meteorological parameters taken to assess their impact on fungal spores were average, maximum and minimum temperature, relative humidity and average wind... περισσότερα »
To serve and to protect: the role of decidual innate immune cells on human pregnancy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
To serve and to protect: the role of decidual innate immune cells on human pregnancy: AbstractThe maternal–fetal interface undergoes dynamic changes that promote successful development of the embryo/fetal allograft during pregnancy. This immune privilege of the conceptus is mediated through local and systemic cellular responses. In species in which endometrial decidualization accompanies pregnancy, unique immune cell niches are found. Many studies have addressed the enigmatic roles of uterine (u)NK cells as killers and helpers because they are frequently found in the uterine lining...περισσότερα »
Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis: AbstractAlthough many studies have demonstrated that components of the hemostatic system may be involved in signaling leading to cancer progression, the potential mechanisms by which they contribute to cancer dissemination are not yet precisely understood. Among known coagulant factors, tissue factor (TF) and thrombin play a pivotal role in cancer invasion. They may be generated in the tumor microenvironment independently of blood coagulation and can induce cell signaling through activation of ... περισσότερα »
Applied anatomy of the anterior cranial fossa
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Applied anatomy of the anterior cranial fossa: what can fracture patterns tell us?: The skull base is uniquely placed to absorb anteriorly directed forces imparted either via the midfacial skeleton or cranial vault. A variety of skull base fracture classifications exist. Less well understood, however, is fracture extension beyond the anterior cranial fossa (ACF) into the middle and posterior cranial fossae. The cases of 81 patients from two UK major trauma centres were studied to examine the distribution of fractures across the skull base and any relationship between the vector of f... περισσότερα »
Schistosomes and schistosomiasis on blood coagulation and fibrinolysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG): AbstractSchistosomes are parasitic platyhelminths that currently infect over 200 million people and cause the chronic debilitating disease schistosomiasis. While these large intravascular parasites can disturb blood flow, surprisingly they do not appear to provoke thrombus formation around them in vivo. In order to determine if the worms can alter their local environment to impede coagulation, we incubated adult worms (50 pairs) in murine blood (50... περισσότερα »
Clopidogrel and prasugrel are antiplatelet therapies
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes: AbstractClopidogrel and prasugrel are antiplatelet therapies commonly used to treat patients with cardiovascular disease. They are both pro-drugs requiring biotransformation into active metabolites. It has been proposed that a genetic variant Q192R (rs662 A>G) in *PON1* significantly alters the biotransformation of clopidogrel and affects clinical outcomes; however, this assertion has limited support. The relationship between this varia... περισσότερα »
Decompression of the Jugular Bulb for Enhanced Infralabyrinthine Access to the Petroclival Region: A Quantitative Analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Decompression of the Jugular Bulb for Enhanced Infralabyrinthine Access to the Petroclival Region: A Quantitative Analysis: J Neurol Surg B DOI: 10.1055/s-0035-1566302 Objectives To describe an enhanced infralabyrinthine approach to petroclival lesions with jugular bulb decompression, and to quantify surgical access using a flat-panel computed tomography image protocol. Design Retrospective case series and paired comparison of pre- versus post-dissection anatomy. Setting Tertiary academic medical center. Participants Four patients presenting with petroclival lesions. Six fresh cadav... περισσότερα »
Surgical Approaches to the Jugular Foramen: A Comprehensive Review
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Surgical Approaches to the Jugular Foramen: A Comprehensive Review: J Neurol Surg B DOI: 10.1055/s-0035-1567863 Introduction Multiple surgical approaches and combinations thereof have been described to gain access to the jugular foramen. In an area laden with important neurovascular structures, care must be taken in choosing the best surgical approach for treatment of rare pathologies involving this region. Methods This manuscript provides a comprehensive review of the relevant anatomy along with an overview of the various approaches to the jugular foramen. In an attempt to simplify...περισσότερα »
Hypopituitarism due to traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), and ischemic stroke (IS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Clinical and diagnostic approach to patients with via International journal of basic and clinical endocrinology AbstractThe hypothalamic-pituitary dysfunction attributable to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH), and ischemic stroke (IS) has been lately highlighted. The diagnosis of TBI-induced-hypopituitarism, defined as a deficient secretion of one or more pituitary hormones, is made similarly to the diagnosis of classical hypopituitarism because of hypothalamic/pituitary diseases. Hypopituitarism is believed to contribute to TBI-associated morbidi... περισσότερα »
Radionuclide therapy using 131 I-labeled anti-epidermal growth factor receptor-targeted nanoparticles suppresses cancer cell growth caused by EGFR overexpression
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Radionuclide therapy using 131 I-labeled anti-epidermal growth factor receptor-targeted nanoparticles suppresses cancer cell growth caused by EGFR overexpression: Abstract IntroductionAnti-epidermal growth factor receptor (EGFR)-targeted nanoparticles can be used to deliver a therapeutic and imaging agent to EGFR-overexpressing tumor cells. 131I-labeled anti-EGFR nanoparticles derived from cetuximab were used as a tumor-targeting vehicle in radionuclide therapy. MethodsThis paper describes the construction of the anti-EGFR nanoparticle EGFR–BSA–PCL. This nanoparticle was chara...περισσότερα »
Impact of restless leg syndrome on mortality in patients on hemodialysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Impact of restless leg syndrome on mortality in patients on hemodialysis: still debatable: The results presented by Stefanidis et al were unexpected [1], since the authors found no association between Restless Leg Syndrome (RLS) and increased mortality among patients on hemodialysis. We agree that this association is controversial in data from the general population. However, RLS in patients with end-stage renal disease, including those on hemodialysis, may have additional non-traditional risk factors, especially mineral and bone disorders(MBD). The literature is almost unanimous re...περισσότερα »
Assessment of dietary cadmium exposure
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 21 δευτερόλεπτα
: A cross-sectional study in rural areas of south China by Food Control via MedWorm: Food Science Highlights • The monthly exposure of Cd was 70.98 μg/kg b.w. in polluted area of south China. • The average estimated lifetime exposure to Cd value was 303.57 mg in polluted area. • Rice was the major polluted foods which accounted for 77.49% in Cd exposure. • Chronic exposure assessment was conducted for the local individuals. ------------------------------ Abstract Individuals exposed to cadmium (Cd) polluted areas and/or Cd-polluted foods are at risk of renal dysfunction. To evaluate the... περισσότερα »
Surgical management of Bisphosphonate-related osteonecrosis of the jaw Stage II and III
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 24 δευτερόλεπτα
Surgical management of Bisphosphonate-related osteonecrosis of the jaw Stage II and III by Jens Philipp Bodem, Carolin Schaal, Steffen Kargus, Daniel Saure, Christian Mertens, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger via Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology The value of surgery in advanced stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still controversially discussed. Hence, we evaluated the effect of surgical therapy in BRONJ stages II and III in combination with a standardized perioperative adjuvant treatment. AbstractObjec... περισσότερα »
Newborn Hearing Screening in a Public Maternity Ward
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Newborn Hearing Screening in a Public Maternity Ward in Curitiba, Brazil: Determining Factors for Not Retesting: Int Arch Otorhinolaryngol DOI: 10.1055/s-0035-1567866 Introduction Law 12.303/10 requires hearing screening in newborns before hospital discharge to detect possible hearing problems within the first three months after birth. If the newborn fails the test or presents signs of risk for hearing loss, it must undergo a retest and monitoring during the first year of life. In practice, this often does not happen. Objective To identify, in a group of mothers of children with ris... περισσότερα »
Audiovisual Spoken Word Recognition as a Clinical Criterion for Sensory Aids Efficiency
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Audiovisual Spoken Word Recognition as a Clinical Criterion for Sensory Aids Efficiency in Persian-Language Children with Hearing Loss: The aim of this study was to examine the role of audiovisual speech recognition as a clinical criterion of cochlear implant or hearing aid efficiency in Persian-language children with severe-to-profound hearing loss. AbstractObjectives The aim of this study was to examine the role of audiovisual speech recognition as a clinical criterion of cochlear implant or hearing aid efficiency in Persian-language children with severe-to-profound hearing los... περισσότερα »
CNS neutrophilic vasculitis in neuro-Sweet disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Asian Pac J Trop Med.4(1):83-4. doi: 10.1016/S1995-7645(11)60041-2. Two uncommon manifestations of leptospirosis: *Sweet's syndrome and central nervous system vasculitis*. George P1. Author information 1Department of Medicine, Yenepoya Medical College, Mangalore, S India. drpetergeorge2002@yahoo.com Abstract To leptospirosis is the commonest spirocheatal infection in the tropical and temperate countries of Indian sub-continent and Africa and the most common zoonosis worldwide. The protean manifestation of this infectious disease is a challenge for practising clinicians across the... περισσότερα »
Enteric nervous system {alpha}-synuclein immunoreactivity in idiopathic REM sleep behavior disorder
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Enteric nervous system {alpha}-synuclein immunoreactivity in idiopathic REM sleep behavior disorder: Objective: To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic biomarker for prodromal Parkinson disease (PD). Methods: Patients with iRBD, patients with PD, and healthy controls were prospectively recruited to undergo colonic biopsies for comparison of α-synuclein immunoreactivity patterns between...περισσότερα »
CNS angiitis as a brain tumor mimic with a branching vascular abnormality on T2* MRI
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
CNS angiitis as a brain tumor mimic with a branching vascular abnormality on T2* MRI: A 24-year-old woman with slowly progressive altered mental status and fevers was found to have multiple brain mass lesions. A characteristic branching vascular pattern on T2* MRI (figure 1D) was key to identifying these mass lesions as vascular in origin. CSF was inflammatory and serologic testing supported the diagnosis of systemic lupus erythematosus with concomitant CNS angiitis affecting deep medullary and ependymal veins, with resulting inflammation, hemorrhage, and infarct. Symptoms and mass...περισσότερα »
Time window for recanalization in basilar artery occlusion
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Time window for recanalization in basilar artery occlusion: Speculative synthesis: Basilar artery occlusion (BAO) is one of the most devastating forms of stroke and few patients have good outcomes without recanalization. Most centers apply recanalization therapies for BAO up to 12–24 hours after symptom onset, which is a substantially longer time window than the 4.5 hours used in anterior circulation stroke. In this speculative synthesis, we discuss recent advances in BAO treatment in order to understand why and under which circumstances longer symptom duration might not necrotize ...περισσότερα »
Mediterranean diet adherence was associated with less brain atrophy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Mediterranean diet and brain structure in a multiethnic elderly cohort: Objective: To determine whether higher adherence to a Mediterranean-type diet (MeDi) is related with larger MRI-measured brain volume or cortical thickness. Methods: In this cross-sectional study, high-resolution structural MRI was collected on 674 elderly (mean age 80.1 years) adults without dementia who participated in a community-based, multiethnic cohort. Dietary information was collected via a food frequency questionnaire. Total brain volume (TBV), total gray matter volume (TGMV), total white matter volume... περισσότερα »
Core journals (Headache, Cephalalgia, and the Journal of Headache and Pain)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Registration status and outcome reporting of trials published in core headache medicine journals: Objectives: To evaluate randomized controlled trial (RCT) registration and outcome reporting compliance in core headache medicine journals. Methods: We identified RCTs published in core journals (*Headache*, *Cephalalgia*, and the *Journal of Headache and Pain*) from 2005 through 2014. We searched articles for trial registration numbers, which were verified in the corresponding trial registry. We categorized trial funding sources as industry, academic, government, or mixed. We contacte...περισσότερα »
Autoimmune post-herpes simplex encephalitis of adults and teenagers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Autoimmune post-herpes simplex encephalitis of adults and teenagers: Objective: To report 14 patients with immune-mediated relapsing symptoms post–herpes simplex encephalitis (HSE) and to compare the clinical and immunologic features of the teenage and adult group with those of young children. Methods: Prospective observational study of patients diagnosed between June 2013 and February 2015. Immunologic techniques have been reported previously. Results: Among the teenage and adult group (8 patients, median age 40 years, range 13–69; 5 male), 3 had an acute symptom presentation sug... περισσότερα »
Angiographic appearance of a cerebral aneurysm rupture
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Angiographic appearance of a cerebral aneurysm rupture: A 53-year-old woman was referred because a CT scan disclosed a subarachnoid hemorrhage. An aneurysm was seen on digital subtraction angiography, which suddenly ruptured (video 1 on the *Neurology*® Web site at Neurology.org) during the study, suggesting the cause of the hemorrhage (video 2). The rate of contrast emission was 3 mL/s with a total volume of 16 mL; the pressure was 200 psi. External ventricular drainage was performed emergently, and the patient was transferred to the intensive care unit. She recovered uneventfully... περισσότερα »
Does REM sleep behavior disorder have the guts to be Parkinson disease?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Does REM sleep behavior disorder have the guts to be Parkinson disease?: Almost 200 years ago, James Parkinson1 described constipation as a frequent and clinically relevant nonmotor symptom in shaking palsy. Recent studies have shown that constipation can precede the motor manifestation of Parkinson disease (PD)2,3 and that constipation is more frequent in idiopathic REM sleep behavior disorder (iRBD) (a potential prodromal stage of PD) compared to controls.4 Even though the causal relationship between constipation and the neurodegenerative process that underlies PD remains debatab...περισσότερα »
Relapse in herpes simplex virus encephalitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Relapse in herpes simplex virus encephalitis: It's not just about the virus: Herpes simplex virus type 1 (HSV) causes approximately 10% of encephalitis cases among humans worldwide, corresponding to an incidence of 1 per 500,000 persons.1 Prior to the development of effective antiviral therapy, which consisted first of vidarabine and later the more effective drug acyclovir, as many as 70% of individuals with HSV encephalitis (HSE) died, and the vast majority of survivors had severe neurologic sequelae. As greater numbers of patients survived HSE, astute clinicians recognized that ...περισσότερα »
Progressive neuropsychological disorders associated with behavior disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Teaching NeuroImages: Ornithine transcarbamylase deficiency revealed by a coma in a pregnant woman: A 32-year-old pregnant (20 weeks of amenorrhea) woman, after change in dietary intake (due to a trip to Korea), developed over 3 weeks progressive neuropsychological disorders associated with behavior disorders. The patient rapidly worsened, and had impaired consciousness and a coma. Biological tests showed hyperammonemia (173 µmol/L), glutamine chromatographic peak, and increased urinary orotic acid concentration. Brain MRI (figure 1) and spectroscopy (figure 2) findings were consis... περισσότερα »
Slowly progressive dysarthria, mild parkinsonism but no tremor : Familial striatal degeneration
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Familial striatal degeneration: New mutation and neuroimaging clues: Autosomal dominant striatal degeneration (ADSD) (MIM 609161) is a rare genetic disease caused by mutation in the *PDE8B* gene.1,2 The disease, with onset in the fourth to fifth decade, is characterized by slowly progressive dysarthria, mild parkinsonism but no tremor, brisk deep tendon reflexes, poor response to levodopa treatment, and distinctive brain MRI findings.1,2 Heterozygous mutations in the *PDE8B* gene, first identified in a German family,2 result in loss of protein cyclic nucleotide phosphodiesterase (P...περισσότερα »
The treatment of pharyngoesophageal perforation following anterior cervical spine intervention
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα
The treatment of pharyngoesophageal perforation following anterior cervical spine intervention: We aimed to investigate the diagnostic and therapeutic approaches in pharyngoesophageal perforation (PEP) following anterior cervical spine intervention (ACSI). AbstractObjective We aimed to investigate the diagnostic and therapeutic approaches in pharyngoesophageal perforation (PEP) following anterior cervical spine intervention (ACSI). Methods We reviewed the records of four patients with PEP after ACSI. Symptoms, physical examination findings, imaging results, treatment, and follow-u... περισσότερα »
EEG Web Based Binary Brain Computer Interfaces to Recover Communication Abilities in Impaired People
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα
A Modular Framework for EEG Web Based Binary Brain Computer Interfaces to Recover Communication Abilities in Impaired People: AbstractA Brain Computer Interface (BCI) allows communication for impaired people unable to express their intention with common channels. Electroencephalography (EEG) represents an effective tool to allow the implementation of a BCI. The present paper describes a modular framework for the implementation of the graphic interface for binary BCIs based on the selection of symbols in a table. The proposed system is also designed to reduce the time required for w... περισσότερα »
Chronic Disease Self-Management
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Development of a Multi-Agent m-Health Application Based on Various Protocols for Chronic Disease Self-Management: AbstractThe purpose of this study was to develop and evaluate a mobile health application (Self-Management mobile Personal Health Record: “SmPHR”) to ensure the interoperability of various personal health devices (PHDs) and electronic medical record systems (EMRs) for continuous self-management of chronic disease patients. The SmPHR was developed for Android 4.0.3, and implemented according to the optimized standard protocol for each interface of healthcare services ado... περισσότερα »
Diagnosis of Brain Metastases
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Diagnosis of Brain Metastases from Lung Cancer Using a Modified Electromagnetism like Mechanism Algorithm: AbstractBrain metastases are commonly found in patients that are diagnosed with primary malignancy on their lung. Lung cancer patients with brain metastasis tend to have a poor survivability, which is less than 6 months in median. Therefore, an early and effective detection system for such disease is needed to help prolong the patients’ survivability and improved their quality of life. A modified electromagnetism-like mechanism (EM) algorithm, MEM-SVM, is proposed by combining...περισσότερα »
Occupational exposure to noise in operating theatres
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Occupational exposure to noise in maxillofacial operating theatres: an initial prospective study: Exposure to excessive noise could impair surgical performance and communication, and lead to long-term hearing loss, but it is only recently that studies on occupational exposure to noise in operating theatres have been published. The aim of this prospective study was to assess mean and peak levels of noise during maxillofacial operations. We found that both were comparable to those in other surgical specialties such as orthopaedics in which power tools are used.
Prevalence and predictors of human papillomavirus (HPV) vaccination among young women surviving childhood cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Prevalence and predictors of human papillomavirus (HPV) vaccination among young women surviving childhood cancer: Abstract PurposeHuman papillomavirus (HPV) is a sexually transmitted infection and the cause of cervical and other cancers. Vaccination is available to protect against genital HPV and is recommended for individuals aged 9–26 years. This study aimed to estimate the prevalence of HPV vaccination among childhood cancer survivors and to identify factors associated with vaccine outcomes. MethodsYoung adult females with (*n* = 114; *M* age = 21.18 years, SD = 2.48) and w... περισσότερα »
Respiratory Laryngeal Coordination in Airflow Conservation and Reduction of Respiratory Effort of Phonation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Respiratory Laryngeal Coordination in Airflow Conservation and Reduction of Respiratory Effort of Phonation: This study evaluates the need of airflow conservation and the effect of glottal resistance on respiratory effort of phonation under different phonation conditions. SummaryObjective This study evaluates the need of airflow conservation and the effect of glottal resistance on respiratory effort of phonation under different phonation conditions. Methods A computational model of the pressure–volume–flow relationship of the respiratory system is developed. Results Simulations sh... περισσότερα »
Maxillary single-jaw surgery combining Le Fort I and modified horseshoe osteotomies for the correction of maxillary excess
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Maxillary single-jaw surgery combining Le Fort I and modified horseshoe osteotomies for the correction of maxillary excess: A modified technique of horseshoe osteotomy combined with Le Fort I osteotomy for superior and posterior repositioning of the maxilla is presented. Eight patients with maxillary excess associated with retrogenia or microgenia were treated with this technique in combination with genioplasty. The maxillary segment was repositioned a maximum of 5.0mm posteriorly and 7.0mm superiorly at point A. The mandible autorotated anterosuperiorly to achieve sound occlusion. ... περισσότερα »
Exportin 1 (XPO1) is a well-characterized nuclear export protein whose expression is up-regulated in many types of cancers and functions to transport key tumor suppressor proteins (TSPs) from the nucleus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds: [image: sfx_links?getImage] Background: Exportin 1 (XPO1) is a well-characterized nuclear export protein whose expression is up-regulated in many types of cancers and functions to transport key tumor suppressor proteins (TSPs) from the nucleus. Karyopharm Therapeutics has developed a series of small-molecule Selective Inhibitor of Nuclear Export (SINE) compounds, which have been shown to block XPO1 function both in vitro and in vivo. The drug candidate, selinexor (K...περισσότερα »
Long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal reconstruction: The aim of this study was to evaluate the long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal/alimentary reconstruction. AbstractPurpose The aim of this study was to evaluate the long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal/alimentary reconstruction. Materials and Methods We reviewed the medical records of four long-term survivors of tracheal agenesis and collected the following d...περισσότερα »
The management of newborns with esophageal atresia and right aortic arch
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
The management of newborns with esophageal atresia and right aortic arch: A systematic review or still unsolved problem: The management of newborns with esophageal atresia (EA) and right aortic arch (RAA) is still an unsolved problem. This study provides a systematic review of epidemiology, diagnosis, management and short-term results of children with EA and RAA. AbstractAim of the study The management of newborns with esophageal atresia (EA) and right aortic arch (RAA) is still an unsolved problem. This study provides a systematic review of epidemiology, diagnosis, management and...περισσότερα »
Most common ‘sporadic’ cancers have a significant germline genetic component
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
*Most common ‘sporadic’ cancers have a significant germline genetic component: Human Molecular Genetics * Cancer typesCasesControlsSNPsArrays*Bladder**2848**3159**505729* *HumanHapmap550**Breast**1081**1085**489247**HumanHapmap550**Australian endometrial cancer**564**574**540995**Human610-Quad, Human1M-Duo**UK endometrial cancer**670**2558**495905**Human610-Quad, Human1M-Duo**Esophageal adenocarcinoma**1397**1947**795160**Omni1-Quad**ESCC**1388**1614**442551* *Human660W-Quad**GC**1342**1624**451186**Human660W-Quad**Kidney**1080**2489* *498235**HumanHapmap550, Human610-Quad, Human660... περισσότερα »
CCL7 and IRF-7 in the host response to rhinovirus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
CCL7 and IRF7 mediate hallmark inflammatory and interferon responses following rhinovirus 1B infection: CCL7 and IRF-7 in the host response to rhinovirus: Journal of immunology (Baltimore, Md. : 1950) Abstract Rhinovirus infections are common and have the potential to exacerbate asthma. We have determined the lung transcriptome in RV strain 1B (RV1B) infected naïve BALB/c mice (non-allergic) and identified CCL7 and IRF7 amongst the most upregulated mRNA transcripts in the lung. To investigate their roles we employed anti-CCL7 antibodies and an IRF7-targeting small interfering RNA... περισσότερα »
Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35): Journal of Virology ABSTRACT High-risk human papillomaviruses (HR-HPV) cause anogenital cancers, including cervical cancer, and head and neck cancers. Human papillomavirus 16 (HPV16) is the most prevalent HR-HPV. HPV oncogenesis is driven by two viral oncoproteins, E6 and E7, which are expressed through alternative splicing of a polycistronic RNA to yield four major splice isoforms (E6 full length, E6*I, E6*II, E6*X). The production of multiple mRNA isoforms from a single ge...περισσότερα »
Tau imaging in neurodegenerative diseases
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Tau imaging in neurodegenerative diseases: AbstractAggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. In AD, it has been shown that the density of hyperphosphorylated tau tangles correlates closely with neuronal dysfunction and cell death, unlike β-amyloid. Until now, diagnostic and pathologic information about tau deposition has only been available from inva...περισσότερα »
Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities in Patients With Metastatic Lung Cancer [Treatment-Related Complications]: Purpose Erlotinib is an epidermal growth factor receptor inhibitor approved for patients with advanced non–small-cell lung cancer (NSCLC) whose epidermal growth factor receptor expression status is positive or unknown. Although it is efficacious, erlotinib can cause skin toxicity. This prospective, randomized ...περισσότερα »
Radiation Dose-Response Relationship for Risk of Coronary Heart Disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma [Treatment-Related Complications]: Purpose Cardiovascular diseases are increasingly recognized as late effects of Hodgkin lymphoma (HL) treatment. The purpose of this study was to identify the risk factors for coronary heart disease (CHD) and to quantify the effects of radiation dose to the heart, chemotherapy, and other cardiovascular risk factors. Patients and Methods We conducted a nested case-control study in a cohort of 2,617 5-year HL survivors, treated between 1965 and 19...περισσότερα »
American Journal of Otolaryngology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Direct application of bFGF without edge trimming on human subacute tympanic membrane perforation To investigate the feasibility of direct application of basic fibroblast growth factor (bFGF) without edge trimming on human subacute traumatic tympanic membrane perforation (TMP). Spontaneous resolution of a petrous apex cholesterol granuloma Cholesterol granuloma is the most common primary lesion of the petrous apex. Management of petrous apex cholesterol granuloma has evolved in recent years from primary surgical treatment to conservative observation. In this article, a case of spontane...περισσότερα »
Fluoropyrimidines are frequently prescribed anticancer drugs
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis [Clinical Trials]: Purpose Fluoropyrimidines are frequently prescribed anticancer drugs. A polymorphism in the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, *DPYD***2A*) is strongly associated with fluoropyrimidine-induced severe and life-threatening toxicity. This study determined the feasibility, safety, and cost of *DPYD***2A* genotype–guided dosing. Patients and Methods Patients intended to be treated with fluoropyrimidine-based chemotherapy were...περισσότερα »
Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology: AbstractHyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammation and allergy, among others. Hyaluronidases are widely distributed in nature and the enzymes from mammalian spermato... περισσότερα »
Tumor necrosis factor-alpha (TNF-α) contributes in inflammation and has been implicated in the development of colorectal cancer (CRC)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer: AbstractTumor necrosis factor-alpha (TNF-α) contributes in inflammation and has been implicated in the development of colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) in *TNF*-*α* promoter could affect the risk of CRC by regulating TNF-α production. This is the first study to investigate *TNF*-*α* SNPs in a Middle Eastern population. In this study, we examined three SNPs in *TNF*-*α* for association with CRC. One hundred CRC patients and 100 controls were genotyped for *... περισσότερα »
Clindamycin Use in Head and Neck Free Tissue Transfer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Increased Surgical Site Infection Rates following Clindamycin Use in Head and Neck Free Tissue Transfer: Objective The development of surgical site infections (SSIs) can put the viability of free tissue transfer reconstructions at risk, often resulting in considerable postoperative morbidity and prolonged hospitalization. Current antibiotic prophylactic guidelines suggest a first- or second-generation cephalosporin with metronidazole for clean-contaminated cases and recommend clindamycin as an alternative choice in penicillin-allergic patients. This study was designed to examine the... περισσότερα »
Evaluation of a novel Surgicric® cricothyroidotomy device for emergency tracheal access
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Evaluation of a novel Surgicric® cricothyroidotomy device for emergency tracheal access in a porcine model: Summary A can't intubate, can't ventilate scenario can result in morbidity and death. Although a rare occurrence (1:50 000 general anaesthetics), it is crucial that anaesthetists maintain the skills necessary to perform cricothyroidotomy, and are well-equipped with appropriate tools. We undertook a bench study comparing a new device, Surgicric®, with two established techniques; the Melker Emergency Cricothyroidotomy, and a surgical technique. Twenty-five anaesthetists perform...περισσότερα »
Direct application of bFGF without edge trimming on human subacute tympanic membrane perforation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Direct application of bFGF without edge trimming on human subacute tympanic membrane perforation: To investigate the feasibility of direct application of basic fibroblast growth factor (bFGF) without edge trimming on human subacute traumatic tympanic membrane perforation (TMP). AbstractObjective To investigate the feasibility of direct application of basic fibroblast growth factor (bFGF) without edge trimming on human subacute traumatic tympanic membrane perforation (TMP). Methods A total of 29 patients with traumatic TMPs beyond 1 month after trauma were enrolled. Patients were p... περισσότερα »
