Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 10 Αυγούστου 2016

OtoRhinoLaryngology & Medicine,New Articles,August 11th,2016


OtoRhinoLaryngology by Sfakianakis G.Alexandros
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic? This Practice Advisory updates the...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study
Summary What is known and objectiveAntimicrobial resistance is one of the greatest threats to human health. One of the most important factors leading to the emergence of resistant bacteria is overuse of antibiotics. The purpose of this study was to investigate the correlation between antimicrobial...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese
Summary What is known and objectiveThe oral plasma clearance of midazolam and the ratio of 6β-hydroxycortisol (6β-OHF) to cortisol (F) in urine are two potential markers for evaluating CYP3A activity in vivo. We assessed the influence of two common CYP3A polymorphisms on the pharmacokinetics of oral...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Effectiveness of temporary implants in teenage patients: a prospective clinical trial
Abstract AimsThe objective of this study was to assess prospectively the outcomes of extra-narrow diameter implants (XNDI) placed in teenage patients as a temporary restorative option. Material and MethodsTwenty consecutive young patients presenting one or several missing teeth received XNDI that...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Do pharmacist-led medication reviews in hospitals help reduce hospital readmissions? A systematic review and meta-analysis
AimThe aim of this meta-analysis was to examine the impact of in-hospital pharmacist-led medication reviews in paediatric and adult patients. MethodsRelevant studies were identified from the Medline and Cochrane Library databases. Studies were included if they met the following criteria (without any...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Why the dynamics are changing for skin whitening in Asia
Skin whitening has been a mega trend in Asia for a number of years now, but with questions over the safety of some ingredients and several skin whitening campaigns causing uproar, the dynamics of the category look set for change. from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2b7S0ut
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Integrating gross pathology into teaching of undergraduate medical science students using human cadavers
Human cadavers offer a great opportunity for histopathology students for the learning and teaching of tissue pathology. In this study, we aimed to implement an integrated learning approach by using cadavers to enhance students’ knowledge and to develop their skills in gross tissue identification, handling...
Medicine by Sfakianakis G. Alexandros
Non-Demented Individuals with Alzheimer’s Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies
Alzheimer's disease (AD) is a terminal neurodegenerative disorder that is characterized by accumulation of amyloid plaques and neurofibrillary tangles in the central nervous system. However, certain individuals remain cognitively intact despite manifestation of substantial plaques and tangles consistent...
Medicine by Sfakianakis G. Alexandros
Repurposing of Anti-Diabetic Agents for the Treatment of Cognitive Impairment and Mood Disorders
Impairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating that these disorders share pathophysiological mechanisms including, but not limited...
Medicine by Sfakianakis G. Alexandros
Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective
Publication date: Available online 10 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): Brian P. Vickery, Jelena P. Berglund, Caitlin M. Burk, Jason P. Fine, Edwin H. Kim, Jung In Kim, Corinne A. Keet, Michael Kulis, Kelly G. Orgel, Rishu Guo, Pamela H. Steele, Yamini V. Virkud,...
Medicine by Sfakianakis G. Alexandros
Dissecting the Mechanisms of Thrombogenesis and Atherosclerosis for Neurodegenerative Disorders
http://ift.tt/29tj1IB
Medicine by Sfakianakis G. Alexandros
Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology
The ascent of polypharmacology in drug development has many implications for disease therapy, most notably in the efforts of drug discovery, drug repositioning, precision medicine and combination therapy. The single- target approach to drug development has encountered difficulties in predicting drugs...
Medicine by Sfakianakis G. Alexandros
David Gergen Selects Top ASBA Diplomates To Speak At the U.S. Senate on Oral Appliance Therapy
David Gergen will lead the delegation of a committee formed with American Sleep and Breathing Academy members that will be presenting to a Caucus Committee of Congress. The hearing is scheduled for September 27, 2016 and it is estimated that 60-80 congressmen, senators and regulators will be in attendance. ...
Medicine by Sfakianakis G. Alexandros
Efficacy of House Dust Mite SLIT-Tablet in North American Adolescents and Adults in a Randomized, Placebo-Controlled Trial
Publication date: Available online 10 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): Hendrik Nolte, David I. Bernstein, Harold S. Nelson, Jörg Kleine-Tebbe, Gordon L. Sussman, Dorthe Seitzberg, Dorte Rehm, Amarjot Kaur, Ziliang Li, Susan Lu BackgroundHouse dust mite (HDM)...
Medicine by Sfakianakis G. Alexandros
Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment
Publication date: Available online 10 August 2016Source:Cortex Author(s): Jiu Chen, Hao Shu, Zan Wang, Yafeng Zhan, Duan Liu, Wenxiang Liao, Lin Xu, Yong Liu, Zhijun Zhang IntroductionBoth remitted late-life depression (rLLD) and amnestic mild cognitive impairment (aMCI) alter brain functions in...
Medicine by Sfakianakis G. Alexandros
Liquid-type Botulinum Toxin Type A in Adductor Spasmodic Dysphonia: A Prospective Pilot Study
Publication date: Available online 9 August 2016Source:Journal of Voice Author(s): Wonjae Cha, Jeon Yeob Jang, Soo-Geun Wang, Ji-Heon Kang, Min-Gyu Jo ObjectivesBotulinum toxin (BTX) has been widely used to treat adductor spasmodic dysphonia (ADSD). Most commercially available forms of BTX require...
Medicine by Sfakianakis G. Alexandros
Tapentadol PR for Pain Syndromes in Real Life Patients with Hematological Malignancy
Background: More than 50% of oncohematological patients suffer from pain syndrome, mostly originating from the bone, which often include nociceptive and neuropathic complaints. Tapentadol, a recently available treatment option for cancer pain, exerts a dual analgesic mechanisms (opioid and noradrenergic),...
Medicine by Sfakianakis G. Alexandros
Educational and process improvements after a simulation-based anaphylaxis simulation workshop
Publication date: Available online 10 August 2016Source:Annals of Allergy, Asthma & Immunology Author(s): Melanie Chong, Diana Pasqua, Jared Kutzin, Mark Davis-Lorton, Luz Fonacier, Marcella Aquino http://ift.tt/2aNH6I9
Medicine by Sfakianakis G. Alexandros
Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia
Baicalin (BA) and jasminoidin (JA) exert an additive effect in the treatment of cerebral ischemia, but the underlying molecular mechanism is still unclear. One hundred mice with focal cerebral ischemia/re-perfusion injury were divided into 5 groups: BA, JA, combination therapy (BJ), sham and vehicle....
Medicine by Sfakianakis G. Alexandros
Pruritus from allergy skin tests in children
Publication date: Available online 10 August 2016Source:Annals of Allergy, Asthma & Immunology Author(s): Sheelagh Stewart, Jennifer Boscher, Jobayer Hossain, Stephen J. McGeady, Ejaz Yousef http://ift.tt/2biazOi
Medicine by Sfakianakis G. Alexandros
Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting. Studies are not currently available on the association between MPV and stroke recovery after...
Medicine by Sfakianakis G. Alexandros
Health-related Quality of Life as Studied by EORTC QLQ and Voice Handicap Index Among Various Patients With Laryngeal Disease
Publication date: Available online 9 August 2016Source:Journal of Voice Author(s): Tom Karlsen, Lorentz Sandvik, John-Helge Heimdal, Marianne Jensen Hjermstad, Anne Kari Hersvik Aarstad, Hans Jørgen Aarstad ObjectivesPatients with voice-related disorders are often treated by a multidisciplinary team...
Medicine by Sfakianakis G. Alexandros
Cytokine Production by SaOS-2 and Mononuclear Cells Cultivated on Alginate Titanium Surfaces Doped with Calcium Phosphates
The immune response of the host tissue to the tested biomaterial predicts the success of implantation therapy success. Connective tissue cell line SaOS-2 and mononuclear cells isolated from "buffy coat" testing determines the overall immune response to the implanted biomaterial. Alginate hydrogel coatings...
Medicine by Sfakianakis G. Alexandros
Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury - A Review
Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described....
Medicine by Sfakianakis G. Alexandros
Guaraná a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation
We investigated the in vitro effects of guaraná and its main metabolites (caffeine, theobromine and catechin) on cytotoxicity and cell proliferation on colorectal cancer (CRC) line HT-29 cells and on oxaliplatin sensitivity. The cells were exposed to different concentrations of guaraná extract with and...
Medicine by Sfakianakis G. Alexandros
DNA Damage and Epigenetic Changes in Kidney Diseases - Focused on Transcription Factors in Podocytes
Recently it has been shown that epigenetic mechanisms are involved in initiation and progression of caridiovascular and metabolic diseases, including diabetes, obesity, atherosclerosis, heart failure, hypertension and kidney diseases. In these chronic diseases, various exogenous and endogenous stresses...
Medicine by Sfakianakis G. Alexandros
Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review
Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the...
Medicine by Sfakianakis G. Alexandros
Prognostic Significance of Asymptomatic Myocardial Ischemia in Women vs. Men
Background: Silent myocardial ischemia is a recognized but suboptimally studied condition in patients with and without known coronary artery disease. Limited work has focused on the association between silent myocardial ischemia and future prognosis however the majority of these analyses have focused...
Medicine by Sfakianakis G. Alexandros
Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders
Background: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development...
Medicine by Sfakianakis G. Alexandros
Cortex Lycii Radicis Extracts Protect Pancreatic Beta Cells Under High Glucose Conditions
The normal function of pancreatic beta cells is vital to the control of blood glucose. Earlier research suggests that the traditional Chinese medicine Cortex Lycii Radicis may help protect pancreatic beta cells and improve insulin sensitivity. However, the specific effects and molecular mechanism of...
Medicine by Sfakianakis G. Alexandros
Beneficial Effects of Dietary Supplements Against Mitochondrial Dysfunction and Apoptosis in Neurodegenerative Diseases
Background: Mitochondria are critically important in providing cellular energy ATP. They also play important roles in anti-oxidant defense, fat oxidation, intermediary metabolism and cell death processes. It is well-established that mitochondrial functions are suppressed through nitroxidative stress...
Medicine by Sfakianakis G. Alexandros
Dabigatran Etexilate Reduces Thrombin-Induced Inflammation and Thrombus Formation in Experimental Ischemic Stroke
Dabigatran etexilate (DE), a direct-acting, oral inhibitor of thrombin, significantly reduces the risk of stroke compared with traditional anticoagulants, without increasing the risk of major bleeding. However, studies on the fate of cerebral tissue after ischemic stroke in patients receiving DE are...
Medicine by Sfakianakis G. Alexandros
Tapentadol PR for Pain Syndromes in Real Life Patients with Hematological Malignancy
Background: More than 50% of oncohematological patients suffer from pain syndrome, mostly originating from the bone, which often include nociceptive and neuropathic complaints. Tapentadol, a recently available treatment option for cancer pain, exerts a dual analgesic mechanisms (opioid and noradrenergic),...
Medicine by Sfakianakis G. Alexandros
Dissecting the Mechanisms of Thrombogenesis and Atherosclerosis for Neurodegenerative Disorders
http://ift.tt/29tj1IB
Medicine by Sfakianakis G. Alexandros
Repurposing of Anti-Diabetic Agents for the Treatment of Cognitive Impairment and Mood Disorders
Impairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating that these disorders share pathophysiological mechanisms including, but not limited...
Medicine by Sfakianakis G. Alexandros
Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment
Publication date: Available online 10 August 2016Source:Cortex Author(s): Jiu Chen, Hao Shu, Zan Wang, Yafeng Zhan, Duan Liu, Wenxiang Liao, Lin Xu, Yong Liu, Zhijun Zhang IntroductionBoth remitted late-life depression (rLLD) and amnestic mild cognitive impairment (aMCI) alter brain functions in...
Medicine by Sfakianakis G. Alexandros
Dabigatran Etexilate Reduces Thrombin-Induced Inflammation and Thrombus Formation in Experimental Ischemic Stroke
Dabigatran etexilate (DE), a direct-acting, oral inhibitor of thrombin, significantly reduces the risk of stroke compared with traditional anticoagulants, without increasing the risk of major bleeding. However, studies on the fate of cerebral tissue after ischemic stroke in patients receiving DE are...
Medicine by Sfakianakis G. Alexandros
Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology
The ascent of polypharmacology in drug development has many implications for disease therapy, most notably in the efforts of drug discovery, drug repositioning, precision medicine and combination therapy. The single- target approach to drug development has encountered difficulties in predicting drugs...
Medicine by Sfakianakis G. Alexandros
Non-Demented Individuals with Alzheimer’s Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies
Alzheimer's disease (AD) is a terminal neurodegenerative disorder that is characterized by accumulation of amyloid plaques and neurofibrillary tangles in the central nervous system. However, certain individuals remain cognitively intact despite manifestation of substantial plaques and tangles consistent...
Medicine by Sfakianakis G. Alexandros
Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia
Baicalin (BA) and jasminoidin (JA) exert an additive effect in the treatment of cerebral ischemia, but the underlying molecular mechanism is still unclear. One hundred mice with focal cerebral ischemia/re-perfusion injury were divided into 5 groups: BA, JA, combination therapy (BJ), sham and vehicle....
Medicine by Sfakianakis G. Alexandros
Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting. Studies are not currently available on the association between MPV and stroke recovery after...
Medicine by Sfakianakis G. Alexandros
Errata: Hypertension and Diabetic Nephropathy
Exp Clin Endocrinol Diabetes DOI: 10.1055/s-0036-1585484 [...] © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text http://ift.tt/2aHCiSL
medicinealexandrossfakianakis
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic? This Practice Advisory updates the...
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study
Summary What is known and objectiveAntimicrobial resistance is one of the greatest threats to human health. One of the most important factors leading to the emergence of resistant bacteria is overuse of antibiotics. The purpose of this study was to investigate the correlation between antimicrobial...
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese
Summary What is known and objectiveThe oral plasma clearance of midazolam and the ratio of 6β-hydroxycortisol (6β-OHF) to cortisol (F) in urine are two potential markers for evaluating CYP3A activity in vivo. We assessed the influence of two common CYP3A polymorphisms on the pharmacokinetics of oral...
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Do pharmacist-led medication reviews in hospitals help reduce hospital readmissions? A systematic review and meta-analysis
AimThe aim of this meta-analysis was to examine the impact of in-hospital pharmacist-led medication reviews in paediatric and adult patients. MethodsRelevant studies were identified from the Medline and Cochrane Library databases. Studies were included if they met the following criteria (without any...
News in OtoRhinoLaryngology - Alexandros G. Sfakianakis
Corrigendum
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OtoRhinoLaryngology - Alexandros G. Sfakianakis
Assessing cardiovascular risk
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic? This Practice Advisory updates the...    
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Emergence Delir
Prophylaxe und Therapie: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 448-457DOI: 10.1055/s-0041-106569 Das Emergence Delirium (ED) ist ein in der Kinderanästhesie bekanntes Phänomen. Problematisch sind trotz fehlender vitaler Gefährdung und i. d. R. kompletter Remission v. a. die Eigen-...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Antihistamines prescribed off-label among paediatric patients
 at a tertiary care hospital setting in Malaysia: Abstract Background Antihistamines are widely prescribed to children but should be used with caution in young children. Objective To determine the paediatric prescribing pattern of antihistamines with a focus on the off-label prescribing and factors...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Influenza viruses (IVs)
Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?: Abstract Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Lymph Node Count From Neck Dissection
 Predicts Mortality in Head and Neck Cancer [Head and Neck Cancer]: Purpose Multiple smaller studies have demonstrated an association between overall survival and lymph node (LN) count from neck dissection in patients with head and neck cancer. This is a large cohort study to examine these associations...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Brain amyloid deposition
The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE: Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE 4 allele status. Methods: Recruited from the longitudinal Atherosclerosis...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Chronic migraine headache prevention with noninvasive vagus nerve stimulation
 The EVENT study: Objective: To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks. Methods: In this first prospective, multicenter, double-blind, sham-controlled pilot study of nVNS in CM prophylaxis,...
health683
Preoperative evaluation and preparation for anesthesia and surgery
Hippokratia. PMCID: PMC2464262 A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131; Email:rg.oohay Go to: Abstract The ultimate goals of preoperative...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Fluoroquinolones
PulmCrit – Six reasons to avoid fluoroquinolones in the critically ill: As an internal medicine resident and pulmonary/critical care fellow, I loved fluoroquinolones. The were effective, easy to prescribe, and they had 100% oral bioavailability. However, working full-time in the ICU has forced...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke)
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke): A 63-year-old man with several vascular risk factors presented with sudden left hemiplegia rapidly evolving to quadriparesis, dysarthria, bilateral hypoglossal palsy (video 1 on the Neurology® Web site at Neurology.org),...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Perimenstrual asthma
 from pathophysiology to treatment strategies: Abstract The prevalence of asthma is about 9,7 % in women and 5,5 % in men. Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity: BACKGROUND Prognostic lymph node yield thresholds have been identified and incorporated into treatment guidelines for multiple cancer sites, but not for oral...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
Human papillomavirus vaccines
Expression of p16INK4A in cervical precancerous lesions is unlikely to be preventable by human papillomavirus vaccines: BACKGROUND Whether higher grade cervical intraepithelial neoplasia (CIN grade 2 or greater [CIN ≥ 2]) that develops because of human papillomavirus (HPV) genotypes not included...
health683
Postoperative pulmonary complications (PPCs)
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Perioperative management of Anticagulation.What are the presenting signs and symptoms of a spinal/ epidural hematoma and how does one manage this potentially catastrophic event?
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
health683
Surgery-Related Predictors for Risk of Perioperative Cardiac Complications
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
health683
Patient-Related Predictors for Risk of Perioperative Cardiac Complications
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology by Sfakianakis G.Alexandros
The effect of yoga in improved cognitive functions
 in medical students: A comparative study: 2016-08-01T15-51-44Z Source: National Journal of Physiology, Pharmacy and Pharmacology Ambareesha Goud Kondam, Nagadeepa W, Jagan N, Jyothinath K, Suresh M, Chandrasekhar M. Background: The medical students experience a lot of stress, which increase when...
health683
Functional Capacity
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
health683
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic? This Practice Advisory updates the “Practice...
health683
Indications for specific preoperative tests
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
health683
American Society of Anesthesiologists’ Classification of Physical Status
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
Human Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Journal of Integrable Systems
Journal of Integrable Systems, published by Oxford University Press, last updated on 2016-08-10, available at http://ift.tt/2b5XrY3 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2b5XrY3 via IFTTT
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
Stereotactic body radiotherapy versus lobectomy for operable clinical stage IA lung adenocarcinoma: comparison of survival outcomes in two clinical trials with propensity score analysis (JCOG1313-A)
Objective No randomized controlled trials comparing stereotactic body radiotherapy and lobectomy for operable early-stage non–small-cell lung cancer have been successfully conducted. This study compared survival outcomes in two multi-institutional clinical trials for stereotactic body radiotherapy (Japan...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
Fertility-sparing surgery for early stage epithelial ovarian cancer
Discussion of fertility-sparing treatment is an important part of pretreatment counseling for young patients with early epithelial ovarian cancer. As a result of late childbearing nowadays, fertility preservation has become a major issue in ovarian cancer patients. The purpose of this review is to update...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
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OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
Clinical significance of a second-line chemotherapy regimen with paclitaxel, ifosfamide and nedaplatin for metastatic urothelial carcinoma after failure of cisplatin-based chemotherapy
Objective Cisplatin-based chemotherapy has been commonly used as the first-line chemotherapy for metastatic urothelial carcinoma. However, after failure of the first-line cisplatin-based chemotherapy, there is no established standard second-line chemotherapy. Starting in 2006, paclitaxel, ifosfamide...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
Influence of positive peritoneal cytology on prognostic factors and survival in early-stage endometrial cancer: a systematic review and meta-analysis
Objective The prognostic significance of positive peritoneal cytology in patients with early-stage endometrial cancer (Stage 1 or 2) is controversial and perhaps depends on the presence of other factors. The relationship of other prognostic factors with positive peritoneal cytology remains unclear....
OtoRhinoLaryngology
Preoperative evaluation and preparation for anesthesia and surgery
Hippokratia. PMCID: PMC2464262A Zambouri4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, GreeceCorresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131; Email:rg.oohay@bazhtaGo to:AbstractThe ultimate goals of preoperative...
OtoRhinoLaryngology
American Society of Anesthesiologists’ Classification of Physical Status
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology
Indications for specific preoperative tests
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, “Hippokratio” G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology  doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic?This Practice Advisory updates the “Practice...
OtoRhinoLaryngology
Emergence Delir
Prophylaxe und Therapie: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 448-457DOI: 10.1055/s-0041-106569Das Emergence Delirium (ED) ist ein in der Kinderanästhesie bekanntes Phänomen. Problematisch sind trotz fehlender vitaler Gefährdung und i. d. R. kompletter Remission v. a. die Eigen- und...
OtoRhinoLaryngology
Antihistamines prescribed off-label among paediatric patients
 at a tertiary care hospital setting in Malaysia: AbstractBackground Antihistamines are widely prescribed to children but should be used with caution in young children. Objective To determine the paediatric prescribing pattern of antihistamines with a focus on the off-label prescribing and factors that...
OtoRhinoLaryngology
Influenza viruses (IVs)
Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?: AbstractInfluenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics...
OtoRhinoLaryngology
Lymph Node Count From Neck Dissection
 Predicts Mortality in Head and Neck Cancer [Head and Neck Cancer]: PurposeMultiple smaller studies have demonstrated an association between overall survival and lymph node (LN) count from neck dissection in patients with head and neck cancer. This is a large cohort study to examine these associations...
OtoRhinoLaryngology
Chronic migraine headache prevention with noninvasive vagus nerve stimulation
 The EVENT study: Objective:To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks.Methods:In this first prospective, multicenter, double-blind, sham-controlled pilot study of nVNS in CM prophylaxis, adults...
OtoRhinoLaryngology
Brain amyloid deposition
The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE: Objective:To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE 4 allele status.Methods:Recruited from the longitudinal Atherosclerosis...
OtoRhinoLaryngology
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke)
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke): A 63-year-old man with several vascular risk factors presented with sudden left hemiplegia rapidly evolving to quadriparesis, dysarthria, bilateral hypoglossal palsy (video 1 on the Neurology® Web site at Neurology.org),...
OtoRhinoLaryngology
Perimenstrual asthma
 from pathophysiology to treatment strategies: AbstractThe prevalence of asthma is about 9,7 % in women and 5,5 % in men.Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is distinguished...
OtoRhinoLaryngology
Fluoroquinolones
PulmCrit – Six reasons to avoid fluoroquinolones in the critically ill: As an internal medicine resident and pulmonary/critical care fellow, I loved fluoroquinolones. The were effective, easy to prescribe, and they had 100% oral bioavailability. However, working full-time in the ICU has forced me to...
OtoRhinoLaryngology
Human papillomavirus vaccines
Expression of p16INK4A in cervical precancerous lesions is unlikely to be preventable by human papillomavirus vaccines: BACKGROUNDWhether higher grade cervical intraepithelial neoplasia (CIN grade 2 or greater [CIN ≥ 2]) that develops because of human papillomavirus (HPV) genotypes not included in vaccines...
OtoRhinoLaryngology
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity: BACKGROUNDPrognostic lymph node yield thresholds have been identified and incorporated into treatment guidelines for multiple cancer sites, but not for oral cancer....
OtoRhinoLaryngology
Dendritic and mast cell involvement in the inflammatory response
 to primary malignant bone tumours: AbstractBackgroundA chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) and mast cells (MCs) have also been identified...
OtoRhinoLaryngology
Performing rapid cricothyrotomies for establishment of an airway,following traumatic battlefield injuries. CricSpike to Speed Up Cricothyrotomies
CricSpike to Speed Up Cricothyrotomies on Battlefield and Hospital: Johns Hopkins University is profiling the work of an undergraduate student team that developed a device for performing rapid cricothyrotomies for establishment of an airway, following traumatic battlefield injuries. Explosions are a...
OtoRhinoLaryngology
The effect of yoga in improved cognitive functions
 in medical students: A comparative study: 2016-08-01T15-51-44ZSource: National Journal of Physiology, Pharmacy and PharmacologyAmbareesha Goud Kondam, Nagadeepa W, Jagan N, Jyothinath K, Suresh M, Chandrasekhar M.Background: The medical students experience a lot of stress, which increase when they appear...
OtoRhinoLaryngology
The production of digital and printed resources from multiple modalities using visualization and three-dimensional printing techniques
The production of digital and printed resources from multiple modalities using visualization and three-dimensional printing techniques: AbstractPurposeVirtual digital resources and printed models have become indispensable tools for medical training and surgical planning. Nevertheless, printed models...
OtoRhinoLaryngology
Cortistatin inhibits calcification of vascular smooth muscle cells
 by depressing osteoblastic differentiation and endoplasmic reticulum stress: AbstractAccumulating evidence has indicated that vascular smooth muscular cells (VSMCs) play an important role in the development of vascular calcification (VC). Cortistatin (CST), a novel bio-active peptide, has been shown...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
The effect of lymphadenectomy on survival and recurrence in patients with ovarian cancer: a systematic review and meta-analysis
Objective Our objective was to perform a meta-analysis examining the effectiveness of lymphadenectomy in patients with ovarian cancer. Methods PubMed and CENTRAL databases were searched on 15 November 2015 using the terms ‘lymphadenectomy’, ‘ovarian cancer’, ‘dissection’, ‘para-aortic’, ‘pelvic’ and...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
A clinical study of multimodal treatment for orbital organ preservation in locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus
Objective This study aimed to investigate the efficacy of induction chemotherapy followed by concurrent chemotherapy and helical tomotherapy in patients with T4b squamous cell carcinoma of the nasal cavity and paranasal sinus in regard to orbital organ preservation and quality of life. Methods Clinical...
OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
BUBR1 overexpression predicts disease-specific survival after nephroureterectomy in patients with upper tract urothelial carcinoma
Objective To date, there are few reliable markers to distinguish tumors with aggressive characteristics in upper tract urothelial carcinoma. The purpose of this study was to identify a biomarker related to genetic instability (chromosomal instability or microsatellite instability) with prognostic value,...

OroFacial Medicine by Alexandros G.Sfakianakis
Effectiveness of temporary implants in teenage patients: a prospective clinical trial
Abstract Aims The objective of this study was to assess prospectively the outcomes of extra-narrow diameter implants (XNDI) placed in teenage patients as a temporary restorative option. Material and Methods Twenty consecutive young patients presenting one or several missing teeth received...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Postoperative pulmonary complications (PPCs)
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
Otolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174
Journal of Integrable Systems
Journal of Integrable Systems, published by Oxford University Press, last updated on 2016-08-10, available at http://ift.tt/2b5XrY3 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2b5XrY3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel...
Evolution of a gene
A New Advanced Backcross Tomato Population Enables High Resolution Leaf QTL Mapping and Gene Identification
Quantitative Trait Locus (QTL) mapping is a powerful technique for dissecting the genetic basis of traits and species differences. Established tomato mapping populations between domesticated tomato (Solanum lycopersicum) and its more distant interfertile relatives typically follow a near isogenic line...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Functional Capacity
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
medicinealexandrossfakianakis
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067 What other guideline statements are available on this topic? This Practice Advisory updates the...
medicinealexandrossfakianakis
Journal of Integrable Systems
Journal of Integrable Systems, published by Oxford University Press, last updated on 2016-08-10, available at http://ift.tt/2b5XrY3 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2b5XrY3 via IFTTT
medicinealexandrossfakianakis
Emergence Delir
Prophylaxe und Therapie: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 448-457DOI: 10.1055/s-0041-106569 Das Emergence Delirium (ED) ist ein in der Kinderanästhesie bekanntes Phänomen. Problematisch sind trotz fehlender vitaler Gefährdung und i. d. R. kompletter Remission v. a. die Eigen-...
medicinealexandrossfakianakis
Antihistamines prescribed off-label among paediatric patients
 at a tertiary care hospital setting in Malaysia: Abstract Background Antihistamines are widely prescribed to children but should be used with caution in young children. Objective To determine the paediatric prescribing pattern of antihistamines with a focus on the off-label prescribing and factors...
medicinealexandrossfakianakis
Influenza viruses (IVs)
Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?: Abstract Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Surgery-Related Predictors for Risk of Perioperative Cardiac Complications
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
medicinealexandrossfakianakis
Lymph Node Count From Neck Dissection
 Predicts Mortality in Head and Neck Cancer [Head and Neck Cancer]: Purpose Multiple smaller studies have demonstrated an association between overall survival and lymph node (LN) count from neck dissection in patients with head and neck cancer. This is a large cohort study to examine these associations...
medicinealexandrossfakianakis
Brain amyloid deposition
The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE: Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE 4 allele status. Methods: Recruited from the longitudinal Atherosclerosis...
medicinealexandrossfakianakis
Chronic migraine headache prevention with noninvasive vagus nerve stimulation
 The EVENT study: Objective: To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks. Methods: In this first prospective, multicenter, double-blind, sham-controlled pilot study of nVNS in CM prophylaxis,...
medicinealexandrossfakianakis
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke)
Complete lingual palsy from bilateral Dejerine syndrome (bilateral medial medullary stroke): A 63-year-old man with several vascular risk factors presented with sudden left hemiplegia rapidly evolving to quadriparesis, dysarthria, bilateral hypoglossal palsy (video 1 on the Neurology® Web site at Neurology.org),...
medicinealexandrossfakianakis
Perimenstrual asthma
 from pathophysiology to treatment strategies: Abstract The prevalence of asthma is about 9,7 % in women and 5,5 % in men. Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is...
medicinealexandrossfakianakis
Fluoroquinolones
PulmCrit – Six reasons to avoid fluoroquinolones in the critically ill: As an internal medicine resident and pulmonary/critical care fellow, I loved fluoroquinolones. The were effective, easy to prescribe, and they had 100% oral bioavailability. However, working full-time in the ICU has forced...
medicinealexandrossfakianakis
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity
Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity: BACKGROUND Prognostic lymph node yield thresholds have been identified and incorporated into treatment guidelines for multiple cancer sites, but not for oral...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Patient-Related Predictors for Risk of Perioperative Cardiac Complications
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
Oncology
Staging discrepancies between Hospital-Based Cancer Registry and Diagnosis Procedure Combination data
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Oncology
Editorial for Urologic Cancer in Asia Series'
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Oncology
Subclassification of high-risk clinically organ-confined prostate cancer for early cancer-specific mortality after radical prostatectomy
ObjectiveHigh-risk clinically localized prostate cancer is seen in a highly heterogeneous population with a wide variation of clinical aggressiveness and a novel subclassification for the better prediction of clinical outcomes is needed. The aim of this study is to validate a modified D’Amico risk criteria...
Oncology
Stereotactic body radiotherapy versus lobectomy for operable clinical stage IA lung adenocarcinoma: comparison of survival outcomes in two clinical trials with propensity score analysis (JCOG1313-A)
ObjectiveNo randomized controlled trials comparing stereotactic body radiotherapy and lobectomy for operable early-stage non–small-cell lung cancer have been successfully conducted. This study compared survival outcomes in two multi-institutional clinical trials for stereotactic body radiotherapy (Japan...
Oncology
Clinical significance of a second-line chemotherapy regimen with paclitaxel, ifosfamide and nedaplatin for metastatic urothelial carcinoma after failure of cisplatin-based chemotherapy
ObjectiveCisplatin-based chemotherapy has been commonly used as the first-line chemotherapy for metastatic urothelial carcinoma. However, after failure of the first-line cisplatin-based chemotherapy, there is no established standard second-line chemotherapy. Starting in 2006, paclitaxel, ifosfamide and...
Oncology
Influence of positive peritoneal cytology on prognostic factors and survival in early-stage endometrial cancer: a systematic review and meta-analysis
ObjectiveThe prognostic significance of positive peritoneal cytology in patients with early-stage endometrial cancer (Stage 1 or 2) is controversial and perhaps depends on the presence of other factors. The relationship of other prognostic factors with positive peritoneal cytology remains unclear. This...
Oncology
Fertility-sparing surgery for early stage epithelial ovarian cancer
Discussion of fertility-sparing treatment is an important part of pretreatment counseling for young patients with early epithelial ovarian cancer. As a result of late childbearing nowadays, fertility preservation has become a major issue in ovarian cancer patients. The purpose of this review is to update...
Oncology
IN THIS ISSUE
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Oncology
BUBR1 overexpression predicts disease-specific survival after nephroureterectomy in patients with upper tract urothelial carcinoma
ObjectiveTo date, there are few reliable markers to distinguish tumors with aggressive characteristics in upper tract urothelial carcinoma. The purpose of this study was to identify a biomarker related to genetic instability (chromosomal instability or microsatellite instability) with prognostic value,...
Oncology
The effect of lymphadenectomy on survival and recurrence in patients with ovarian cancer: a systematic review and meta-analysis
ObjectiveOur objective was to perform a meta-analysis examining the effectiveness of lymphadenectomy in patients with ovarian cancer. MethodsPubMed and CENTRAL databases were searched on 15 November 2015 using the terms ‘lymphadenectomy’, ‘ovarian cancer’, ‘dissection’, ‘para-aortic’, ‘pelvic’ and...
Oncology
Clinical practice patterns for upper tract urothelial carcinoma: a nationwide survey in Japan
ObjectiveA comprehensive survey has not yet been conducted to investigate care patterns by urologists for the management of upper tract urothelial carcinoma. MethodsWe conducted a nationwide survey for urologists treating upper tract urothelial carcinoma patients. The questionnaire was approved by...
Oncology
A clinical study of multimodal treatment for orbital organ preservation in locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus
ObjectiveThis study aimed to investigate the efficacy of induction chemotherapy followed by concurrent chemotherapy and helical tomotherapy in patients with T4b squamous cell carcinoma of the nasal cavity and paranasal sinus in regard to orbital organ preservation and quality of life. MethodsClinical...
Oncology
Incidence rates for colon cancer of Japanese in Japan and in the United States from the Cancer Incidence in Five Continents
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Oncology
Coffee drinking and colorectal cancer risk: an evaluation based on a systematic review and meta-analysis among the Japanese population
ObjectiveIt remains unclear whether coffee drinking is associated with colorectal cancer risk. We performed a systematic review and meta-analysis of epidemiologic studies on this issue among the Japanese population. MethodsOriginal data were obtained from MEDLINE searches using PubMed or from searches...
Oncology
The outcomes of reconstruction using frozen autograft combined with iodine-coated implants for malignant bone tumors: compared with non-coated implants
ObjectiveWe perform reconstruction using frozen tumor bone treated by liquid nitrogen after excision of malignant bone tumors. To prevent post-operative infection, we use iodine-coated implants that we developed. The purpose of this study is to compare the outcome of reconstruction using frozen autograft...
Oncology
Randomized feasibility study of S-1 for adjuvant chemotherapy in completely resected Stage IA non-small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 0701
ObjectiveThe aim of this multicenter study was to determine the appropriate administration schedule for S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with completely resected pathological-Stage IA (tumor diameter, 2–3 cm) non–small-cell lung cancer. MethodsPatients were randomly...
Oncology
The role of pharmacogenetics in capecitabine efficacy and toxicity
Publication date: Available online 10 August 2016Source:Cancer Treatment Reviews Author(s): S.W. Lam, H.J. Guchelaar, E. BovenCapecitabine is an oral prodrug of 5-fluorouracil (5-FU) and approved for treatment of various malignancies. Hereditary genetic variants may affect a drug’s pharmacokinetics...
Oncology
Trabectedin in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is characterized by widespread resistance to systemic therapy. Trabectedin is an antineoplastic agent targeting both the malignant cells and the tumor microenvironment which has been approved for the treatment of advanced soft tissue sarcoma and ovarian cancer. In...
Oncology
BPR1J373 targets c-KIT for c-KIT driven myeloid leukemia
Acute myeloid leukemia (AML) carrying t(8;21)(q22;q22) or inv(16)/t(16;16)(p13;q22) is classified as core binding factor (CBF)-AML and accounts for approximately 15% of AML. C-KIT mutation can be detected in 17~46% of CBF-AML and is associated with poor prognosis. C-KIT mutation is a crucial hit and...
Oncology
Staging discrepancies between Hospital-Based Cancer Registry and Diagnosis Procedure Combination data
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OtoRhinoLaryngology - Alexandros G. Sfakianakis
Preoperative evaluation and preparation for anesthesia and surgery
Hippokratia. PMCID: PMC2464262A Zambouri4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, GreeceCorresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131; Email:rg.oohay@bazhtaGo to:AbstractThe ultimate goals of preoperative...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
American Society of Anesthesiologists’ Classification of Physical Status
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Indications for specific preoperative tests
Hippokratia. PMCID: PMC2464262 Preoperative evaluation and preparation for anesthesia and surgery A Zambouri 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece Corresponding author: Zambouri A, 4th Dept of Anesthesiology, "Hippokratio" G. H., Thessaloniki, Greece, tel: 2310 346131;...
Θεραπεία
Do pharmacist-led medication reviews in hospitals help reduce hospital readmissions? A systematic review and meta-analysis
Aim The aim of this meta-analysis was to examine the impact of in-hospital pharmacist-led medication reviews in paediatric and adult patients. Methods Relevant studies were identified from the Medline and Cochrane Library databases. Studies were included if they met the following criteria...
health683
Perimenstrual asthma
from pathophysiology to treatment strategies: Abstract The prevalence of asthma is about 9,7 % in women and 5,5 % in men. Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Preanesthesia Evaluation
Practice Advisory for Preanesthesia Evaluation: An Updated Report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation Anesthesiology doi:10.1097/ALN.0b013e31823c1067What other guideline statements are available on this topic?This Practice Advisory updates the “Practice...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Subclassification of high-risk clinically organ-confined prostate cancer for early cancer-specific mortality after radical prostatectomy
ObjectiveHigh-risk clinically localized prostate cancer is seen in a highly heterogeneous population with a wide variation of clinical aggressiveness and a novel subclassification for the better prediction of clinical outcomes is needed. The aim of this study is to validate a modified D’Amico risk criteria...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Staging discrepancies between Hospital-Based Cancer Registry and Diagnosis Procedure Combination data
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OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Editorial for Urologic Cancer in Asia Series'
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OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Stereotactic body radiotherapy versus lobectomy for operable clinical stage IA lung adenocarcinoma: comparison of survival outcomes in two clinical trials with propensity score analysis (JCOG1313-A)
ObjectiveNo randomized controlled trials comparing stereotactic body radiotherapy and lobectomy for operable early-stage non–small-cell lung cancer have been successfully conducted. This study compared survival outcomes in two multi-institutional clinical trials for stereotactic body radiotherapy (Japan...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Fertility-sparing surgery for early stage epithelial ovarian cancer
Discussion of fertility-sparing treatment is an important part of pretreatment counseling for young patients with early epithelial ovarian cancer. As a result of late childbearing nowadays, fertility preservation has become a major issue in ovarian cancer patients. The purpose of this review is to update...