Extrathoracic mechanical ventilation on pulmonary hypertension
Effects of extrathoracic mechanical ventilation on pulmonary hypertension secondary to lung disease: Abstract PurposeBiphasic cuirass ventilation (BCV) is a form of non-invasive extrathoracic positive and negative pressure mechanical ventilation. The present study was conducted to quantify our positive experience using BCV to dramatically improve gas exchange and cardiac function in patients with acute exacerbation of chronic respiratory failure and secondary pulmonary hypertension (PH). MethodsBCV was applied for 2 weeks in 17 patients with PH caused by lung disease. Ventilat...περισσότερα »
6 Inexpensive Pulse Oximeters
The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications.: BACKGROUND: Universal access to pulse oximetry worldwide is often limited by cost and has substantial public health consequences. Low-cost pulse oximeters have become increasingly available with limited regulatory agency oversight. The accuracy of these devices often has not been validated, raising questions about performance. METHODS: The accuracy of 6 low-cost finger pulse oximeters during stable arterial oxygen saturations (SaO2) between ... περισσότερα »
Vaccine-Preventable Diseases
Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications.: Vaccine-preventable diseases (VPDs) such as measles and pertussis are becoming more common in the United States. This disturbing trend is driven by several factors, including the antivaccination movement, waning efficacy of certain vaccines, pathogen adaptation, and travel of individuals to and from areas where disease is endemic. The anesthesia-related manifestations of many VPDs involve airway complications, cardiovascular and respiratory compromise, and unusual neurologic ... περισσότερα »
Atomized Lidocaine Administered via the Trachea
The Pharmacokinetics of Atomized Lidocaine Administered via the Trachea: A Randomized Trial.: BACKGROUND: Under emergent conditions, endotracheal drug administration may be an effective method of delivering emergency drugs. A common technique is to administer these drugs using a nonatomized spray. Atomized drug delivery may be an attractive alternative to nonatomized delivery because atomized particles are small, cover a large surface area, and may better adhere to endotracheal membrane resulting in more effective drug absorption. In this study, we compared the pharmacokinetic profil... περισσότερα »
Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury
in Rats.: BACKGROUND: Noxious stimulus-induced analgesia (NSIA) is a type of conditioned pain modulation in rats that has been used to assess endogenous pain control systems. The descending noradrenergic system is involved in NSIA, and nerve injury induces plastic changes of descending noradrenergic neurons. Thus, we hypothesized that nerve injury would affect NSIA strength and that amitriptyline and pregabalin, which often are used for treating neuropathic pain, might further modulate NSIA through effects on the descending noradrenergic system. METHODS: We examined the change in N...περισσότερα »
Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts
Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts: Abstract Background The prevalence of allergic rhinitis is high but the role of environmental factors remains unclear. We examined cohort-specific and combined associations of residential greenness with allergic rhinitis and aeroallergen sensitization based on individual data from Swedish (BAMSE), Australian (MACS), Dutch (PIAMA), Canadian (CAPPS and SAGE) and German (GINIplus and LISAplus) birth cohorts (N=13,016). Methods Allergic rhinitis (doc... περισσότερα »
Childhood atopic dermatitis - Brain-derived neurotrophic factor
correlates with serum ECP and disease severity: [image: cover.gif?v=1&s=eca9898eab49b7d92da2055c] Abstract Several studies have shown that neurotrophins including brain-derived neurotrophic factor (BDNF) play a role in chronic inflammatory skin diseases such as atopic dermatitis (AD). BDNF is increased in serum samples of adults with AD. Interestingly, eosinophils of these patients can release and produce BDNF. We analyzed BDNF serum levels with ELISA and their correlation with SCORAD score, eosinophil cationic protein (ECP), total IgE, IL-4, IL-13 and IL-31 in children with AD... περισσότερα »
Mepolizumab in severe eosinophilic asthma patients with previous omalizumab treatment
Treatment response with Abstract Background We performed *post-hoc* analyses to evaluate the effect of humanized monoclonal antibody mepolizumab in patients with severe eosinophilic asthma previously treated with omalizumab. Methods Data were collected from two randomized double-blind, placebo-controlled studies: MENSA (NCT01691521: 32-week treatment phase) and SIRIUS (NCT01691508: 24-week treatment phase). Active treatment was 75 mg intravenous mepolizumab (MENSA) or 100 mg subcutaneous mepolizumab (MENSA, SIRIUS). Patients had evidence of eosinophilic inflammation ≥150 cells/μl (... περισσότερα »
Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2) promote allergic inflammation.
IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function via Allergy and Clinical Immunology Publication date: Available online 18 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Magali Noval Rivas, Oliver T. Burton, Hans C. Oettgen, Talal Chatila BackgroundFood allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2) promote allergic inflammation. However their role in food allergy is largely unknown.ObjectiveWe sought to investigate the role of ILC2 in foo... περισσότερα »
World Allergy Organization Journal
Debates in allergy medicine: Specific immunotherapy in children with atopic dermatitis, the “con” view Atopic dermatitis (AD) is a common chronic skin condition in children that has a proven association with other atopic conditions and allergies. These associations, like the general pathophysiology of AD, are c... Debates in allergy medicine: specific immunotherapy efficiency in children with atopic dermatitis Allergen specific immunotherapy (AIT) has been the only pathogenetically relevant treatment of IgE-mediated allergic diseases (ADs) for many years. The use of AIT for atopic de... περισσότερα »
Respiratory Syncytial Virus-Induced Exacerbations : TNF-{alpha} and Macrophages Are Critical
TNF-{alpha} and Macrophages Are Critical for Respiratory Syncytial Virus-Induced Exacerbations in a Mouse Model of Allergic Airways Disease [ALLERGY AND OTHER HYPERSENSITIVITIES]: Viral respiratory infections trigger severe exacerbations of asthma, worsen disease symptoms, and impair lung function. To investigate the mechanisms underlying viral exacerbation, we established a mouse model of respiratory syncytial virus (RSV)–induced exacerbation after allergen sensitization and challenge. RSV infection of OVA-sensitized/challenged BALB/c mice resulted in significantly increased airwa... περισσότερα »
Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units
The presence of MERS-CoV was confirmed by RT-PCR from viral cultures of 4 out of 7 air samples and 15 out of 68 surface swab samples from three MERS patients' rooms, calling for epidemiologic investigation for contact and airborne transmission. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1SoUYYS via IFTTT
Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008-2012
This is the first comprehensive 5-year report of enteric fever surveillance data in the United States. The report describes incidence and patient exposures for typhoid and paratyphoid A and antimicrobial resistance patterns for *Salmonella* Typhi and Paratyphi A isolates. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1qVa5Ad via IFTTT
Colonization with Methicillin-Resistant Staphylococcus aureus and Risk for Infection among Asymptomatic Athletes: A Systematic Review and Meta-Analysis
Athletes are vulnerable to MRSA infection. We found that 8% of USA athletes are colonized with MRSA and collegiate athletes, particularly, reach 13%. The risk for MRSA infection among colonized athletes was significantly higher than non-colonized. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1SoUYYG via IFTTT
Nocardia infection in solid organ transplant recipients: a multicenter European case-control study
In this European multicenter case-control study, *Nocardia* infection after organ transplantation was associated with high blood concentrations of calcineurin inhibitors, use of tacrolimus, dose of corticosteroids, patient age and length of stay in the intensive care unit after transplantation. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1qVa5zZ via IFTTT
Implementation of Nationwide Real-Time Whole-Genome Sequencing to Enhance Listeriosis Outbreak Detection and Investigation
Implementation of whole-genome sequencing (WGS)-based surveillance for *Listeria monocytogenes* in 2013 greatly improved detection and investigation of listeriosis outbreaks in the United States. Lessons from this intervention can guide WGS-based surveillance for other foodborne pathogens. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1SoUYIc via IFTTT
Hypertension among HIV-infected Patients in Clinical Care, 1996 - 2013
In a study of a clinic HIV cohort, we found that hypertension incidence has increased in recent years. Although traditional risk factors were associated with hypertension, we found that low CD4 nadir may also be independently associated with incident hypertension. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1qVa3bA via IFTTT
Subcutaneous Allergic Sensitization to Protease Allergen
Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes [ALLERGY AND OTHER HYPERSENSITIVITIES]: Protease activity of papain, a plant-derived occupational allergen homologous to mite major allergens, is essential to IgE/IgG1 production and lung eosinophilia induced by intranasal papain administration in mice, and IL-33 contributes to these responses. In this work, we investigate skin and Ab responses induced by s.c. papain administration into ear lobes and responses induced by subsequent airway challenge with papain. Subcutaneous pap...περισσότερα »
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease
[ALLERGY AND OTHER HYPERSENSITIVITIES]: T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK, and regulatory T cells, is known as an inhibitory molecule that limits autoimmunity, antiviral and antitumor immunity. In this report, we demonstrate that TIGIT enhances Th2 immunity. TIGIT expression was upregulated in activated Th2 cells from mice with experimental allergic disease and in Th2 polarization cultures. In addition, its high-affinity ligand CD155 was upregulated in mediastinal lymph node dendritic cells from allergic mice. In an in vitro setting, we observed that *...περισσότερα »
Streptococcus pneumoniae-Induced Immunosuppression
Pneumococcal Surface Protein A Plays a Major Role in Streptococcus pneumoniae-Induced Immunosuppression [IMMUNE REGULATION]: Intact, inactivated *Streptococcus pneumoniae* [including the unencapsulated *S. pneumoniae,* serotype 2 strain (R36A)] markedly inhibits the humoral immune response to coimmunized heterologous proteins, a property not observed with several other intact Gram-positive or Gram-negative bacteria. In this study, we determined the nature of this immunosuppressive property. Because phosphorylcholine (PC), a major haptenic component of teichoic acid in the *S. pneum... περισσότερα »
Topical Application of Fingolimod Perturbs Cutaneous Inflammation
[INNATE IMMUNITY AND INFLAMMATION]: The prevalence of allergies, including rhinitis, eczema, and anaphylaxis, is rising dramatically worldwide. This increase is especially problematic in children who bear the greatest burden of this rising trend. Increasing evidence identifies neutrophils as primary perpetrators of the more severe and difficult to manage forms of inflammation. A newly recognized mechanism by which neutrophils are recruited during the early phase of histamine-induced inflammation involves the sphingosine kinase (SK)/sphingosine-1-phosphate axis. This study examines...περισσότερα »
Hepatic encephalopathy (HE) due to intrahepatic portosystemic shunt after total gastrectomy
A 67-year-old woman was admitted in the department of Neurology for investigation of recurrent episodes of mental confusion and speech difficulty lasting 3–4 days. Between the episodes she was presenting somnolence and flapping tremor. The symptoms started shortly after gastrectomy followed by chemotherapy for gastric non-Hodgkin's lymphoma. Haematological profile, liver biochemistry, thyroid function and immunology tests were normal. Serum ammonia levels were 174μg/dL (normal <35μg/dL). CT scan and MRI of brain were unremarkable. from thyroid via a.lsfakia on Inoreader http://ift... περισσότερα »
Prospective evaluation of the utility of routine neuromonitoring for an established thyroid surgical practice
Background The use of routine intraoperative neuromonitoring (IONM) is controversial in thyroid surgery. Guidelines have been published to standardize IONM. This study examines the impact of routine IONM on a high-volume thyroid surgeon. Methods A prospective study was conducted using IONM between May 2013 and December 2014. Demographics, type of operation, pathology, recurrent laryngeal nerve (RLN) and external branch of the superior laryngeal nerve (EBSLN) visualization and sub-type classification, cricothyroid or cricopharyngeal twitch/electrode depolarization were obtained, ...περισσότερα »
32nd International Austrian Winter Symposium
Table of contents A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CT W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti A2 F18 Choline PET – CT: an accurate diagnostic tool for the detection of parathyroid adenoma? L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W Langsteger A3 [18F]Fluoro-DOPA-PET/CT in the primary diagnosis of medullary thyroid carcinoma A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, ... περισσότερα »
Frequency of thyroid status monitoring in the first year of life and predictors for more frequent monitoring in infants with congenital hypothyroidism
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print from thyroid via a.lsfakia on Inoreader http://ift.tt/20Rndm3 via IFTTT
The Australasian Society of Clinical Immunology and Allergy (ASCIA) News
ASCIA News - Changes to adrenaline autoinjector labels Apr 19 2016: In Australia, adrenaline is the approved name of the ingredient in autoinjector devices used for the emergency treatment of anaphylaxis. Currently, the only available autoinjector to treat anaphylaxis in Australia and New Zealand is supplied under the brand name EpiPen®. In some countries, including the USA, adrenaline... - How are you managing your pollen allergies in a changing global climate? ... περισσότερα »
[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
*[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].* Bull Cancer. 2016 Apr 13; Authors: Nahet A, Boublenza L, Hassaine H, Masdoua N, Prétet JL, Belglaiaa E, Mougin C Abstract OBJECTIVES: To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014. MATERIAL AND METHODS: Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was pro... περισσότερα »
[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
*[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].* Bull Cancer. 2016 Apr 13; Authors: Nahet A, Boublenza L, Hassaine H, Masdoua N, Prétet JL, Belglaiaa E, Mougin C Abstract OBJECTIVES: To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014. MATERIAL AND METHODS: Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was pro... περισσότερα »
Extra Nodal Rosai–Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy) Presenting as Asymmetric Bilateral Optic Atrophy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Abstract Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy, SHML) is a rare, non-hereditary, benign histiocytic proliferative disorder, presenting as painless bilateral cervical lymphadenopathy, with systemic symptoms. Extra nodal manifestations have been reported in 28–43 % cases with rare ocular involvement. We report a case of a 57 year old female presenting with gradual progressive decrease […]
Recurrent Mastoiditis Mimics IgG4 Related Disease: A Potential Diagnostic Pitfall
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Abstract IgG4-related disease (IgG4-RD) is a recently recognized entity that causes progressive fibrosis and formation of mass lesions. IgG4-RD can be diagnosed histologically by its hallmarks of storiform fibrosis, prominent lymphoplasmacytic infiltrate, and obliterative phlebitis, accompanied by the infiltration of excessive numbers of IgG4-positive plasma cells as well as elevations in serum IgG4 concentrations. A […]
Desmoid-Type Fibromatosis of the Tongue
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Abstract Desmoid-type fibromatosis rarely occurs in the oral tongue. Diagnostic imaging, including ultrasound, is useful for delineating the extent of the lesion and can aid in treatment planning. However, definitive diagnosis is made based on the characteristic histologic features, which include cytologically bland spindle cells with surrounding collagenous matrix and minimal mitotic activity. Immunohistochemical analysis […]
Loneliness, social isolation and social relationships: what are we measuring? A novel framework for classifying and comparing tools
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives We present a novel way of classifying and comparing measures of social relationships to help readers interpret the growing literature on loneliness and social isolation and to provide researchers with a starting point to guide their choice of measuring tool. Methods Measures of social relationships used in epidemiological studies were identified from two systematic […]
PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Introduction Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, […]
Disaster anxiety and self-assistance behaviours among persons with cervical cord injury in Japan: a qualitative study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives Persons with disabilities, especially those with a severe disability, have a vague anxiety about future disasters; however, the measures of self-assistance for disaster preparedness have not been standardised. The present study aimed to describe disaster-related anxiety and behaviours related to disaster preparedness among persons who have cervical cord injury in Japan. Design Qualitative study. […]
Examining mortality risk and rate of ageing among Polish Olympic athletes: a survival follow-up from 1924 to 2012
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives Population-based studies have shown that an active lifestyle reduces mortality risk. Therefore, it has been a longstanding belief that individuals who engage in frequent exercise will experience a slower rate of ageing. It is uncertain whether this widely-accepted assumption holds for intense wear-and-tear. Here, using the 88 years survival follow-up data of Polish Olympic […]
Associations of behavioural risk factors and health status with changes in physical capability over 10 years of follow-up: the MRC National Survey of Health and Development
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives (1) To describe changes in objective measures of physical capability between ages 53 and 60–64 years; (2) to investigate the associations of behavioural risk factors (obesity, physical inactivity, smoking) and number of health conditions (range 0–4: hand osteoarthritis (OA); knee OA; severe respiratory symptoms; other disabling or life-threatening conditions (ie, cancer, cardiovascular disease, diabetes)) […]
An audit of the quality of inpatient care for adults with learning disability in the UK
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives To audit patient hospital records to evaluate the performance of acute general and mental health services in delivering inpatient care to people with learning disability and explore the influence of organisational factors on the quality of care they deliver. Setting Nine acute general hospital Trusts and six mental health services. Participants Adults with learning […]
Less than full-time training in surgery: a cross-sectional study evaluating the accessibility and experiences of flexible training in the surgical trainee workforce
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Objectives Generational changes in lifestyle expectations, working environments and the feminisation of the medical workforce have seen an increased demand in postgraduate less than full-time training (LTFT). Despite this, concerns remain regarding access to, and information about, flexible training for surgeons. This study aimed to assess the opinions and experiences of LTFT for surgical trainees. […]
C1 esterase inhibitor ameliorates ischemia reperfusion injury in a swine musculocutaneous flap model
C1 esterase inhibitor ameliorates ischemia reperfusion injury in a swine musculocutaneous flap model: Purpose Free tissue transfer is a powerful reconstructive surgical technique. The ischemia reperfusion injury (IRI) at revascularization affects the flap and the patient; reducing this insult could improve outcomes. This study evaluated the effect of C1 esterase inhibitor (C1-inh) on IRI in a porcine musculocutaneous flap model. Materials and methods A musculocutaneous flap was transferred from the limb to the neck of 12 swine. Flaps underwent a 3-hour ischemic interval prior to re... περισσότερα »
Sleep bruxism with age, sleep apnea and daytime problematic behaviors in children
Associations of Abstract Objectives The aims of this study were to investigate the prevalence of sleep bruxism in children in Japan, and its relationships with sleep-related factors and daytime problematic behavior. Subjects and Methods Guardians of 6023 children aged 2-12 years completed the Japanese Sleep Questionnaire. Multiple regression analysis and structural equation modeling were performed. Results Sleep bruxism was reported in 21.0% children (n = 1263): the prevalence was highest in the age group of 5 to 7 years (27.4%). Multiple regression analysis showed that sleep bruxis... περισσότερα »
The Oral Microbiome
Comparison of the Oral Microbiome of Siblings Using Next-generation Sequencing: a Pilot Study: Abstract Objective The purpose of this study was to compare the oral microbiome of siblings with and without dental caries using next-generation sequencing. Materials and Methods To investigate the oral microbiome composition, 14 young siblings, 7 with caries and 7 without, were enrolled from seven sibling-pair families. Supragingival plaque samples were collected from the cervicobuccal area of posterior teeth. All samples were analyzed by pyrosequencing, based on the 16S rRNA gene hyperva...περισσότερα »
pH and calcium ions release from different calcium hydroxide pastes
Measurement of pH and calcium ions release from different calcium hydroxide pastes at different intervals of time: Atomic spectrophotometric analysis via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 16 April 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Pranab Misra, Rhythm Bains, Kapil Loomba, Abhinav Singh, V.P. Sharma, R.C. Murthy, Rakesh Kumar AimTo evaluate the effect of different vehicles on pH and release of calcium ions from calcium hydroxide (CH) paste from apical third of root cana...περισσότερα »
Intraoral technique for locking reconstruction plate fixation
using an implant handpiece with adapted drills: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Locking reconstruction plates are used in the treatment of jaw trauma and diseases if there is a need for surgical resection and to prevent pathologic fracture after tumor excision. Fixation is typically performed using an extraoral approach. Methods This article describes a technique for the intraoral fixation of locking reconstruction plates that uses prototyping to model the plate before the procedure as well as an implant handpiece with adapted drills for bon...περισσότερα »
Role of Malleus relocation in cholesteatoma surgery
Our experience in 145 patients: Abstract The goals of cholesteatoma surgery are complete eradication of the disease and if possible restoration of hearing of the patient. A technique that allows a surgeon to achieve these goals. The advantages of the intact canal technique are rapid healing and being more functional. But cholesteatoma recidivism is common after this technique. The introduction of malleus relocation technique favors the use of the repositioned malleus in ossiculoplasty with more stable ossiculoplasty and better hearing outcomes*.* But no study has presented its role ... περισσότερα »
Subjective apnea symptoms are associated with daytime sleepiness
in patients with moderate and severe obstructive sleep apnea: a retrospective study: Abstract Objectives Most previous studies have failed to show a relation between daytime sleepiness and apnea severity in patients with obstructive sleep apnea (OSA). We determined the relation between daytime sleepiness and subjective and objective apnea severity in newly-diagnosed patients with moderate to severe OSA. Design Retrospective cross-sectional study. Setting Tertiary referral centre. Participants A total of 559 adults with newly-diagnosed moderate and severe OSA. Main outcome measures D...περισσότερα »
Interleukin-1 beta enhances inflammatory Th2 differentiation
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Under inflammatory conditions where IL-1β is present, iTh2 cells exacerbate allergic responses critical in orchestrating asthmatic lung immunopathology, suggesting IL-1 signalling on CD4 as a critical target in allergic asthma. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23UZbZn via IFTTT
IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
IL-4 production by ILC2 plays a crucial role in enabling sensitization to food allergens. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/26c33Hx via IFTTT
Hematopoietic stem cell transplantation for CTLA4 deficiency
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Pathogenic mutations in cytotoxic T lymphocyte antigen 4 (CTLA4) behave in an autosomal-dominant manner with incomplete penetrance, resulting in a complex immune dysregulation syndrome with disrupted T- and B-cell homeostasis.1-3 Kuehn et al1 identified 7 patients from 4 families with lymphoproliferation, organ infiltration, autoimmune cytopenias, and B-cell abnormalities. Schubert et al2 identified 14 patients from […]
How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Abstract The number and severity of diseases affecting human lung development and adult respiratory function has stimulated great interest in new in vitro models to study the human lung. This review summarizes the most recent breakthroughs deriving lung lineages in a dish by directing the differentiation of human pluripotent stem cells. A variety of culturing […]
Improving outcomes for nasal bone fractures
An Asian perspective on improving outcomes for nasal bone fractures by establishing specific treatment options: Abstract Objective To report treatment outcomes of patients with different types of nasal bone fracture, following a tailored treatment protocol. Design The patterns and the severity of the fractures were determined by a preoperative facial photo and nasal bone computed tomography (CT) retrospectively. Setting A tertiary referral center. Participants We evaluated 129 patients who underwent surgery between March 2002 and January 2014. Patients were subjected to five differen... περισσότερα »
Identifying at Diagnosis the Vestibular Schwannomas
at Low Risk of Growth in a Long-term Retrospective Cohort: [image: cover.gif?v=1&s=2dae28c1c9e85b722640525a] Abstract Objectives Identification at time of diagnosis of those vestibular schwannomas that will not grow. Design Retrospective cohort study of consecutive patients diagnosed with a sporadic vestibular schwannoma that were entered in the wait-and-scan protocol. Setting Academic referral centre. Participants The study group contained 155 patients with a sporadic vestibular schwannoma first seen in the full 8-year period 2000-2007: continual wait-and-scan (n = 89) and init... περισσότερα »
Role of antifungal medicaments added to tissue conditioners
A systematic review.: J Prosthodont Res. 2016 Apr ; Authors: Iqbal Z, Zafar MS Abstract PURPOSE: The aim of this review is to investigate the current state of knowledge on the incorporation of antifungal agents into the tissue conditioners for the treatment of denture induced stomatitis. STUDY SELECTION: Studies reporting the incorporation of antifungal/antimicrobial agents in to tissue conditioners were included in the review. In order to search the studies on the topic "incorporation of antifungal agents in tissue conditioners for the treatment of denture induced stomatitis" IS... περισσότερα »
Radiotherapy After Oesophageal Cancer Stenting
ROCS *Condition*: Oesophageal Cancer *Intervention*: Radiation: Radiotherapy *Sponsor*: Lisette Nixon The single most distressing symptom for more than 70% of patients with oesophageal cancer is difficulty in swallowing (dysphagia) caused by blockage of the gullet by a tumour. This causes severe restrictions on food intake, physical activity, social functioning and overall quality of life. Amongst the more effective treatments for improving swallowing, is the insertion of a metal stent across the blocked part, which then self-expands to open up the gullet (Self Expandin... περισσότερα »
Induction Gemcitabine and Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma in the Era of IMRT
The Role of : *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Gemcitabine; Drug: cisplatin; Drug: cisplatin; Radiation: Intensity-modulated Radiotherapy *Sponsor*: Sun Yat-sen University ArmsAssigned Interventions Experimental: Experimental Induction chemotherapy+IMRT gemcitabine and cisplatin regimen Patients receive gemcitabine (1000 mg/m² d1,8) and cisplatin (80mg/m² d1) every 3 weeks for 2 cycles before radiotherapy, and then receive intensity modulated-radiotherapy (IMRT). Drug: Gemcitabine Experimental arm: Patients receive gemcitabine (1000 mg/m²... περισσότερα »
Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
• Multiple myeloma (MM) cells regulate 19 miRNAs in mesenchymal stromal cells (MSC).• MM cell-derived exosomes transfer miR-146a into MSC.• miR-146a promotes cytokine secretion in MSC, favoring MM cell growth and migration.• Inhibition of the Notch pathway reduces miR-146a-induced cytokine secretion in MSC. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TgbAlB via IFTTT Medicine by Alexandros […]
The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Glioblastoma (GBM) is the most aggressive and incurable form of astrocytoma with over 10,000 new cases estimated to be diagnosed in 2015 [1]. The average survival time after diagnosis is 12–14 months [2–4]. The standard of care for GBM is maximal surgical resection followed by radiation and chemotherapy [5]. GBM tumors are heterogeneous and contain […]
Potential antitumor activity of novel DODAC PHO-S liposomes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Luna ACL, Saraiva GKV, Filho OMR, Chierice GO, Neto SC, Cuccovia IM, Maria DA from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SriuHA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Emotion, working memory, and cognitive control in patients with first-onset and previously untreated minor depressive disorders
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objective To explore working memory and the ability to process different emotional stimuli in patients with first-onset and untreated minor (mild or moderate) depression. Methods Patients with first-onset and previously untreated minor depression, and healthy controls, were enrolled. Using a modified Sternberg working memory paradigm to investigate the combined effects of emotional stimuli with working […]
Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objective To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma. Method This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated […]
An investigation into potential gender-specific differences in myocardial triglyceride content assessed by 1H-Magnetic Resonance Spectroscopy at 3Tesla
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objective Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy (1H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals. Methods Cardiac MR imaging […]
Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
• Multiple myeloma (MM) cells regulate 19 miRNAs in mesenchymal stromal cells (MSC).• MM cell-derived exosomes transfer miR-146a into MSC.• miR-146a promotes cytokine secretion in MSC, favoring MM cell growth and migration.• Inhibition of the Notch pathway reduces miR-146a-induced cytokine secretion in MSC. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TgbAlB via IFTTT Medicine by Alexandros […]
The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Glioblastoma (GBM) is the most aggressive and incurable form of astrocytoma with over 10,000 new cases estimated to be diagnosed in 2015 [1]. The average survival time after diagnosis is 12–14 months [2–4]. The standard of care for GBM is maximal surgical resection followed by radiation and chemotherapy [5]. GBM tumors are heterogeneous and contain […]
Postulation of rust resistance genes in Nordic spring wheat genotypes and identification of widely effective sources of resistance against the Australian rust flora
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Wild relatives, landraces and cultivars from different geographical regions have been demonstrated as the sources of genetic variation for resistance to rust diseases. This study involved assessment of diversity for resistance to three rust diseases among a set of Nordic spring wheat cultivars. These cultivars were tested at the seedling stage against several pathotypes […]
What Do We Measure in Oncology PET?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Positron emission tomography (PET) has come to the practice of oncology. It is known that 18F-fluorodeoxyglucose (FDG) PET is more sensitive for the assessment of treatment response than conventional imaging. In addition, PET has an advantage in the use of quantitative analysis of the study. Nowadays, various PET parameters are adopted in clinical settings. […]
Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Study Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Study of *Condition*: Head and Neck Cancer *Interventions*: Biological: Nivolumab; Biological: Ipilimumab; Drug: Cetuximab/Erbitux; Drug: Cisplatin/Platinol; Drug: Carboplatin/Paraplatin; Drug: Fluorouracil/Adrucil *Sponsor*: Bristol-Myers Squibb ArmsAssigned Interventions Experimental: Nivolumab and Ipilimumab Specified dose on specified days Biological: Nivolumab Other Names: - BMS-936558 - Opdivo Biological: Ipilimumab Other Names: - BMS-734016 - Yervoy Active Comparator: Extreme Regimen Specified dose on specified days Drug: Cetuximab/Erb... περισσότερα »
Clarithromycin Dose-Dependently Stabilizes Peritoneal Mast Cells
Rat Peritoneal Mast Cells: *Background:* Macrolides, such as clarithromycin, have antiallergic properties. Since exocytosis in mast cells is detected electrophysiologically via changes in membrane capacitance (Cm), the absence of such changes due to the drug indicates its mast cell-stabilizing effect. *Methods:* Employing the whole-cell patch clamp technique in rat peritoneal mast cells, we examined the effects of clarithromycin on Cm during exocytosis. Using a water-soluble fluorescent dye, we also examined its effect on deformation of the plasma membrane. *Results:* Clarithromycin... περισσότερα »
Clinical evaluation of acute phase nystagmus associated with cerebellar lesions
Main ArticleClinical evaluation of acute phase nystagmus associated with cerebellar lesionsY Ogawaa1 c1, K Otsukaa1, A Hagiwaraa1, T Inagakia1, S Shimizua1, N Nagaia1, U Konomia1, S Itania1, T Kondoa1 and M Suzukia1 a1 Department of Otorhinolaryngology, Tokyo Medical University, Japan Abstract Objectives: To determine the characteristics of acute phase nystagmus in patients with cerebellar lesions, and to identify a useful indicator for differentiating central lesions from peripheral lesions. Methods: Acute phase nystagmus and the appearance of neurological symptoms were retrospectivel...περισσότερα »
Effect of intratympanic steroid administration on sensorineural hearing loss associated with acute otitis media
Main ArticleEffect of intratympanic steroid administration on sensorineural hearing loss associated with acute otitis mediaR L Heywooda1 c1, S N Ifeacho a1 and A A Narulaa1 a1 Department of Otolaryngology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK Abstract Objective: To evaluate a small cohort of patients who presented with symptoms and signs consistent with acute infective sensorineural hearing loss who were treated with intratympanic steroids. Method: Seven patients received a 7-day course of oral antibiotics and oral prednisolone followed by 3 intratympan... περισσότερα »
Parasympathetic Nervous System Dysfunction, as Identified by Pupil Light Reflex, and Its Possible Connection to Hearing Impairment
Parasympathetic Nervous System Dysfunction, as Identified by Pupil Light Reflex, and Its Possible Connection to Hearing Impairment: by Yang Wang, Adriana A. Zekveld, Graham Naylor, Barbara Ohlenforst, Elise P. Jansma, Artur Lorens, Thomas Lunner, Sophia E. Kramer Context Although the pupil light reflex has been widely used as a clinical diagnostic tool for autonomic nervous system dysfunction, there is no systematic review available to summarize the evidence that the pupil light reflex is a sensitive method to detect parasympathetic dysfunction. Meanwhile, the relationship betwee... περισσότερα »
Desmoid-Type Fibromatosis of the Tongue
Desmoid-Type Fibromatosis of the Tongue: AbstractDesmoid-type fibromatosis rarely occurs in the oral tongue. Diagnostic imaging, including ultrasound, is useful for delineating the extent of the lesion and can aid in treatment planning. However, definitive diagnosis is made based on the characteristic histologic features, which include cytologically bland spindle cells with surrounding collagenous matrix and minimal mitotic activity. Immunohistochemical analysis of these lesions reveals that they are classically positive, at least focally, for smooth muscle actin, calponin and musc... περισσότερα »
Recurrent Mastoiditis Mimics IgG4 Related Disease
A Potential Diagnostic Pitfall: AbstractIgG4-related disease (IgG4-RD) is a recently recognized entity that causes progressive fibrosis and formation of mass lesions. IgG4-RD can be diagnosed histologically by its hallmarks of storiform fibrosis, prominent lymphoplasmacytic infiltrate, and obliterative phlebitis, accompanied by the infiltration of excessive numbers of IgG4-positive plasma cells as well as elevations in serum IgG4 concentrations. A recent publication reported a case of IgG4-RD in the mastoid sinus, representing a new anatomic location for this disease. We report two... περισσότερα »
Asymmetric Bilateral Optic Atrophy: Extra Nodal Rosai–Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy)
Extra Nodal Rosai–Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy) Presenting as Asymmetric Bilateral Optic Atrophy: AbstractRosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy, SHML) is a rare, non-hereditary, benign histiocytic proliferative disorder, presenting as painless bilateral cervical lymphadenopathy, with systemic symptoms. Extra nodal manifestations have been reported in 28–43 % cases with rare ocular involvement. We report a case of a 57 year old female presenting with gradual progressive decrease of vision OU since 8 months associ...περισσότερα »
Histone H1 on the Progression of Allergic Rhinitis
Impact of Histone H1 on the Progression of Allergic Rhinitis and Its Suppression by Neutralizing Antibody in Mice: by Toshiaki Nakano, Rikiya Kamei, Takashi Fujimura, Yuki Takaoka, Ayane Hori, Chia-Yun Lai, Kuei-Chen Chiang, Yayoi Shimada, Naoya Ohmori, Takeshi Goto, Kazuhisa Ono, Chao-Long Chen, Shigeru Goto, Seiji Kawamoto Nuclear antigens are known to trigger off innate and adaptive immune responses. Recent studies have found that the complex of nucleic acids and core histones that are derived from damaged cells may regulate allergic responses. However, no fundamental study has ... περισσότερα »
Gene fusions and somatic mutations in salivary gland neoplasms
The landscape of gene fusions and somatic mutations in salivary gland neoplasms – Implications for diagnosis and therapy: [image: gr1.sml] Salivary gland tumors are a heterogeneous group of benign and malignant neoplasms that pose significant diagnostic difficulties due to the multitude of histopathologic subtypes and the rarity of many of the lesions [1]. There is also morphologic overlap between several subtypes, making it difficult to determine whether they are, in fact, separate entities or variants of the same spectrum [1]. Clinically, malignant salivary neoplasms may vary... περισσότερα »
Change of nystagmus direction during a head-roll test in lateral semicircular canal cupulolithiasis
Change of nystagmus direction during a head-roll test in lateral semicircular canal cupulolithiasis: To demonstrate positional nystagmus during a head-roll test in two patients with lateral semicircular canal (LSCC) cupulolithiasis who presented with spontaneous detachment of otoliths from the LSCC cupula, and to confirm that otoliths may adhere to both the utricle and canal sides of the cupula. AbstractObjective To demonstrate positional nystagmus during a head-roll test in two patients with lateral semicircular canal (LSCC) cupulolithiasis who presented with spontaneous detachm... περισσότερα »
ESCC : Lymphovascular invasion of tumor cells in lymph node metastases
has a negative impact on survival in esophageal cancer.: Surgery. 2016 Apr ; Authors: Schiefer AI, Schoppmann S, Birner P Abstract BACKGROUND: Lymph node metastases constitute a strong prognostic factor in esophageal cancer. Nevertheless, the mechanisms and relevance of further spread of tumor cells from these already established metastatic sites have not been studied in this disease. The aim of this study was to investigate lymphatic vessel invasion (LVI) of tumor cells and lymphatic microvessel density in lymph node metastases in a large cohort of patients with node-positive es...περισσότερα »
Proton pump inhibitor-induced hypomagnesaemia
Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia: Summary Background Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg2+, can be a severe side effect of chronic PPI use. Aim To restore serum Mg2+ concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres. Methods Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/da... περισσότερα »
Voice Rehabilitation After Radiotherapy
Voice Range Profile and Health-related Quality of Life Measurements Following Voice Rehabilitation After Radiotherapy; a Randomized Controlled Study via Voice Publication date: Available online 15 April 2016 *Source:*Journal of Voice Author(s): Lisa Tuomi, Mia Johansson, Ellen Lindell, Lena Folkestad, Maria Malmerfors, Caterina Finizia PurposeThe aim of the present study was to investigate the effects of voice rehabilitation in patients treated with radiotherapy for laryngeal cancer.MethodA total of 42 patients with laryngeal cancer who are treated with radiotherapy with curative inte...περισσότερα »
ReSound's Directional Philosophy
ReSound's Directional Philosophy: Dr. John Nelson: Today I will discuss how ReSound implements directional processing in our hearing aids. We know that directional hearing aids provide a significant benefit in laboratory settings. When conducting studies, we will typically place a listener in an audio sound booth in a controlled listening situation. An example of a controlled listening situation is where a speech signal comes from the front of the listener, and noise comes from the back. This setting does not represent a real-world situation. However, when we perform laboratory stud... περισσότερα »
Hoarseness in Persons with Hyperfunctional Voice Disorder
Spectral Measures of via Voice Publication date: Available online 11 April 2016 *Source:*Journal of Voice Author(s): Narasimhan S.V, Vishal K The purpose of the present investigation was to understand the spectral differences between individuals with hyperfunctional voice disorders and subjects with normal voice in terms of H1-H2, H1-A1, H1-A2, and H1-A3 (H1, first harmonic amplitude; H2, second harmonic amplitude; A1, amplitude of the most robust harmonic in the region of first formant frequency; A2, amplitude of the strongest harmonic component in the region of second formant frequ...περισσότερα »
Voice Handicap Index (VHI)-30 scores and objective acoustic measures
Correlation of VHI-30 to Acoustic Measurements Across Three Common Voice Disorders via Voice Publication date: Available online 13 April 2016 *Source:*Journal of Voice Author(s): Ali Dehqan, Fariba Yadegari, Ronald C. Scherer, Peyman Dabirmoghadam ObjectivesVoice disorders that affect the quality of voice also result in varying degrees of psychological and social problems. The research question here is whether the correlations between Voice Handicap Index (VHI)-30 scores and objective acoustic measures differ in patients with different types of voice disorders.MethodsThe subjects were... περισσότερα »
Screening for Voice Disorders in Older Adults (RAVI)
—Part III: Cutoff Score and Clinical Consistency via Voice Publication date: Available online 13 April 2016 *Source:*Journal of Voice Author(s): Leandro Pernambuco, Albert Espelt, Kenio Costa de Lima AimThe aim of the study was to determine the cutoff score and clinical consistency of “Screening for Voice Disorders in Older Adults” (RAVI—Rastreamento de Alterações Vocais em Idosos).Study DesignThis is a prospective, nonrandomized, cross-sectional diagnostic study.MethodsA sample of 301 subjects, including both sexes, aged 60 and more, and all of whom were living in either a community o... περισσότερα »
Transsexual Voice Questionnaire
for Male-to-female Brazilian Transsexual People via Voice Publication date: Available online 14 April 2016 *Source:*Journal of Voice Author(s): Karine Schwarz, Anna Martha Vaitses Fontanari, Andressa Mueller, Angelo Brandelli Costa, Bianca Soll, Dhiordan Cardoso da Silva, Carla Aparecida Cielo, Gabriel Kuhl, Poli Mara Spritzer, Maiko Abel Schneider, Maria Elza Dorfmann, Maria Inês Rodrigues Lobato ObjectivesThe aim of the study was to verify the answers to the transsexual voice questionnaire for male-to-female transsexual (TVQMtF) people given to individuals who participated in the Ge... περισσότερα »
Lexical Stress on the Use of Vocal Fry
The Role of Lexical Stress on the Use of Vocal Fry in Young Adult Female Speakers via Voice Publication date: Available online 15 April 2016 *Source:*Journal of Voice Author(s): Todd A. Gibson ObjectivesVocal fry is a voice register often used by young adult women for sociolinguistic purposes. Some acoustic correlates of lexical stress, however, appear incompatible with the use of vocal fry. The objective of this study was to systematically examine the role of lexical stress in the use of vocal fry by young adult women.Study DesignThis is a semi-randomized controlled laboratory study....περισσότερα »
Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task
Differentiating School-Aged Children With and Without Language Impairment Using Tense and Grammaticality Measures From a Narrative Task: Purpose To determine the diagnostic accuracy of the finite verb morphology composite (FVMC), number of errors per C-unit (Errors/CU), and percent grammatical C-units (PGCUs) in differentiating school-aged children with language impairment (LI) and those with typical language development (TL). Method Participants were 61 six-year-olds (50 TL, 11 LI) and 67 eight-year-olds (50 TL, 17 LI). Narrative samples were collected using a story-generation fo...περισσότερα »
Parasympathetic Nervous System Dysfunction, as Identified by Pupil Light Reflex, and Its Possible Connection to Hearing Impairment
Parasympathetic Nervous System Dysfunction, as Identified by Pupil Light Reflex, and Its Possible Connection to Hearing Impairment: by Yang Wang, Adriana A. Zekveld, Graham Naylor, Barbara Ohlenforst, Elise P. Jansma, Artur Lorens, Thomas Lunner, Sophia E. Kramer Context Although the pupil light reflex has been widely used as a clinical diagnostic tool for autonomic nervous system dysfunction, there is no systematic review available to summarize the evidence that the pupil light reflex is a sensitive method to detect parasympathetic dysfunction. Meanwhile, the relationship betwee... περισσότερα »
The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans
The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans: by Ola Alsalman, Jan Ost, Robby Vanspauwen, Catherine Blaivie, Dirk De Ridder, Sven Vanneste Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a un... περισσότερα »
Are Cardiac Autonomic Nervous System Activity and Perceived Stress Related to Functional Somatic Symptoms in Adolescents? The TRAILS Study
Are Cardiac Autonomic Nervous System Activity and Perceived Stress Related to Functional Somatic Symptoms in Adolescents? The TRAILS Study: by Karin A. M. Janssens, Harriëtte Riese, Arie M. Van Roon, Joke A. M. Hunfeld, Paul F. C. Groot, Albertine J. Oldehinkel, Judith G. M. Rosmalen Objective Stressors have been related to medically insufficiently explained or functional somatic symptoms (FSS). However, the underlying mechanism of this association is largely unclear. In the current study, we examined whether FSS are associated with different perceived stress and cardiac autonomi...περισσότερα »
Pseudomonas aeruginosa AlgU contributes to posttranscriptional activity
by increasing rsmA expression in a mucA22 strain [PublishAheadOfPrint]: *Pseudomonas aeruginosa* thrives in multiple environments and is capable of causing life-threatening infections in immunocompromised patients. RsmA is a posttranscriptional regulator that controls virulence factor production and biofilm formation. In this study, we investigated the expression and activity of *rsmA*/RsmA in *P. aeruginosa* *mucA* mutant strains, which are common in chronic infections. We determined that AlgU regulates a previously unknown *rsmA* promoter in *P. aeruginosa*. Western blot analysi...περισσότερα »
Tinnitus And Musical Genius
Tinnitus And Musical Genius: When you think of tinnitus, you usually don’t think of musical genius as well. However, to the surprise of many people, some of the biggest names in music history have suffered with this condition that causes ringing in the ears. Yet despite the difficulties this can cause, those who have the condition have not let it keep them from turning out some of the greatest hits in music history. To find out how tinnitus and musical genius go together, take a look at some of the most well-known musicians who have had this condition. Neil Young One of the most ... περισσότερα »
Potential antitumor activity of novel DODAC PHO-S liposomes
Luna ACL, Saraiva GKV, Filho OMR, Chierice GO, Neto SC, Cuccovia IM, Maria DA from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SriuHA via IFTTT
Emotion, working memory, and cognitive control in patients with first-onset and previously untreated minor depressive disorders
Objective To explore working memory and the ability to process different emotional stimuli in patients with first-onset and untreated minor (mild or moderate) depression. Methods Patients with first-onset and previously untreated minor depression, and healthy controls, were enrolled. Using a modified Sternberg working memory paradigm to investigate the combined effects of emotional stimuli with working… Continue reading Emotion, working memory, and cognitive control in patients with first-onset and previously untreated minor depressive disorders
Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour
Objective To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma. Method This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated… Continue reading Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour
An investigation into potential gender-specific differences in myocardial triglyceride content assessed by 1H-Magnetic Resonance Spectroscopy at 3Tesla
Objective Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy (1H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals. Methods Cardiac MR imaging… Continue reading An investigation into potential gender-specific differences in myocardial triglyceride content assessed by 1H-Magnetic Resonance Spectroscopy at 3Tesla
Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity
• Multiple myeloma (MM) cells regulate 19 miRNAs in mesenchymal stromal cells (MSC).• MM cell-derived exosomes transfer miR-146a into MSC.• miR-146a promotes cytokine secretion in MSC, favoring MM cell growth and migration.• Inhibition of the Notch pathway reduces miR-146a-induced cytokine secretion in MSC. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TgbAlB via IFTTT
The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma
• HMGA2 is validated as a potential therapeutic target in GBM.• High levels of HMGA2 are present in GBM tumors, cell lines and stem-like cells.• HMGA2 promotes GBM stemness, invasion and in vivo tumor formation. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SrfV8x via IFTTT
Postulation of rust resistance genes in Nordic spring wheat genotypes and identification of widely effective sources of resistance against the Australian rust flora
Abstract Wild relatives, landraces and cultivars from different geographical regions have been demonstrated as the sources of genetic variation for resistance to rust diseases. This study involved assessment of diversity for resistance to three rust diseases among a set of Nordic spring wheat cultivars. These cultivars were tested at the seedling stage against several pathotypes… Continue reading Postulation of rust resistance genes in Nordic spring wheat genotypes and identification of widely effective sources of resistance against the Australian rust flora
Prophylactic irradiation of para-aortic lymph nodes for patients with locally advanced cervical cancers with and without high CA9 expression (KROG 07-01): A randomized open-label multicenter phase 2 trial
[image: gr1.sml] The efficacy of prophylactic extended-field irradiation (EFI) plus concomitant cisplatin in patients with locally advanced uterine cervical cancer (LAUCC) is unknown, nor is it known whether tumor carbonic anhydrase IX (CA9) expression level, a hypoxia marker, influences survival outcome. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1SoJuVh
A national approach for automated collection of standardized and population-based radiation therapy data in Sweden
[image: gr1.sml] To develop an infrastructure for structured and automated collection of interoperable radiation therapy (RT) data into a national clinical quality registry. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1SoJxjG
Effect of Photobiomodulation on Transforming Growth Factor-β1, Platelet-Derived Growth Factor-BB, and Interl eukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
Photomedicine and Laser Surgery , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SreHtY via IFTTT
