AAO-HNS Guidelines for the Definition of Menieres Disease
2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Menieres Disease: Ménière’s disease is a disorder of the inner ear that causes attacks of vertigo and hearing loss, tinnitus, aural fullness in the involved ear. Over the past 4 decades, the Equilibrium Committee of the AAO-HNS has issued guidelines for diagnostic criteria, with the latest version being published in 1995. These criteria were reviewed in 2015 by the Equilibrium Committee, and revisions were approved at the recent meeting of the committee at the 2015 AAO-HNSF Annual Meeting. The...περισσότερα »
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy: Objective To describe surgical outcomes and perioperative complications in patients taking antiplatelet and anticoagulation medications while undergoing cochlear implantation. Study Design Case series with chart review. Setting Two tertiary otologic referral center. Subjects and Methods Forty-six adult patients (2005-2014) who underwent cochlear implantation while on perioperative antiplatelet and/or anticoagulation therapy without interruption. Outcomes included estimated intraoperat... περισσότερα »
Adaptation of the Arabic Version of the Tinnitus Handicap Inventory
Adaptation of the Arabic Version of the Tinnitus Handicap Inventory: Objective To translate the Tinnitus Handicap Inventory (THI) into literary Arabic to come up with a unified Arabic version and to determine its validity and reliability in assessing the quality of life of Arabic-speaking patients with tinnitus. Study Design Clinical measurement study. Setting Tertiary care center. Subjects and methods The original English THI was translated into literary Arabic by a forward- and back-translation process according to the published guidelines for cross-cultural adaptation of hea... περισσότερα »
Eustachian Tube Function in 6-Year-Old Children with and without a History of Middle Ear Disease
Eustachian Tube Function in 6-Year-Old Children with and without a History of Middle Ear Disease: Objective To test the hypothesis that eustachian tube opening efficiency, measured as the fractional gradient equilibrated (FGE), is lower in 6-year-old children with no middle ear disease but a well-documented history of recurrent acute otitis media, as compared with children with a negative disease history (control). Study Design Cross-sectional study. Setting Tertiary care pediatric hospital. Subjects and Methods Bilateral eustachian tube function was evaluated in 44 healthy 6-ye... περισσότερα »
Detecting Residual/Recurrent Head Neck Squamous Cell Carcinomas Using PET or PET/CT: Systematic Review and Meta-analysis
Detecting Residual/Recurrent Head Neck Squamous Cell Carcinomas Using PET or PET/CT: Systematic Review and Meta-analysis: Objective To evaluate the diagnostic accuracy of positron emission tomography (PET) and PET/computed tomography (CT) for detecting residual and/or recurrent local and regional disease and distant metastases in patients with head and neck squamous cell carcinomas (HNSCCs) following radiotherapy with or without chemotherapy. Data Sources A systematic review with no language restrictions was conducted using PREMEDLINE, MEDLINE, EMBASE, and Google Scholar. Review M... περισσότερα »
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap: Posterior glottic stenosis is a difficult clinical problem that frequently results in bilateral vocal fold immobility, dyspnea, and tracheostomy dependence. Charts were reviewed of all patients undergoing a modified endoscopic postcricoid advancement flap procedure for posterior glottic stenosis between October 1, 2003, and June 30, 2015. Age, sex, operative findings, complications, and outcomes were noted. Follow-up was available in 10 of 11 patients, 10 of whom were successfully decann... περισσότερα »
Shared Decision Making and Choice for Elective Surgical Care
Shared Decision Making and Choice for Elective Surgical Care: A Systematic Review: Objective Shared decision making (SDM), an integrative patient-provider communication process emphasizing discussion of scientific evidence and patient/family values, may improve quality care delivery, promote evidence-based practice, and reduce overuse of surgical care. Little is known, however, regarding SDM in elective surgical practice. The purpose of this systematic review is to synthesize findings of studies evaluating use and outcomes of SDM in elective surgery. Data Sources PubMed, Cochrane ...περισσότερα »
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty: Objective To compare the viscoelastic properties of calcium hydroxyapatite (CaHA) to carboxymethylcellulose (CMC) injectables used for injection laryngoplasty and determine if they are affected by heating and shearing. Study Design Experimental. Setting University laboratory. Subjects and Methods Vocal fold injection laryngoplasty with CaHA is oftentimes challenging due to the amount of pressure necessary to push the injectate through a needle. Anecdotal t... περισσότερα »
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients: Objective This study aims to evaluate Apnea-Hypopnea Index (AHI) outcomes of upper airway adult obstructive sleep apnea (OSA) reconstructive surgery, as compared with outcomes of suboptimal continuous positive airway pressure (CPAP) therapy, in response to reviews claiming unreliable surgical AHI reduction. Study Design Prospective cohort study. Setting Single-surgeon series at medical centers within Wollongong, Australia. Subjects and Methods Adult patients with OSA who were part... περισσότερα »
Laryngeal Manifestations of Neurofibromatosis
Laryngeal Manifestations of Neurofibromatosis: Objectives To describe the range of findings in patients with neurofibromatosis (NF) presenting to a laryngology clinic and to analyze the etiologic factors of vocal fold dysfunction in this cohort. Study Design Case series with chart review. Setting Tertiary laryngology practice. Subjects and Methods All cases of NF presenting to an academic laryngology practice were retrospectively reviewed (August 2005 to May 2014), with a total of 34 cases. Demographic data, symptoms, and endoscopic examination findings were reviewed. Etiologic ... περισσότερα »
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation: Objective Adult abdominal fat, which is known to contain pluripotent stem cells, is frequently used to treat cerebrospinal fluid leak. The aim of this study was to assess the efficacy and reliability of abdominal fat graft to close large skull base defects after extirpation of malignant sinonasal tumors. Study Design Case series with chart review performed between 2009 and 2014. Subjects and Methods Twenty-nine cases were included of consecutive patients who were suffering ... περισσότερα »
Inpatient Pediatric Tonsillectomy: Does Hospital Type Affect Cost and Outcomes of Care?
Inpatient Pediatric Tonsillectomy: Does Hospital Type Affect Cost and Outcomes of Care?: Objective To ascertain whether hospital type is associated with differences in total cost and outcomes for inpatient tonsillectomy. Study Design Cross-sectional analysis of the 2006, 2009, and 2012 Kids’ Inpatient Database (KID). Subjects and Methods Children ≤18 years of age undergoing tonsillectomy with/without adenoidectomy were included. Risk-adjusted generalized linear models assessed for differences in hospital cost and length of stay (LOS) among children managed by (1) non–children’s t... περισσότερα »
Proanthocyanidins affects the neurotoxicity of Aβ25-35 on C57/bl6 mice
*OBJECTIVE:* To investigate the influence of procyanidins on the impairment of memory. *MATERIALS AND METHODS:* Thirty male C57bl/6 mice were divided into five groups: low, middle, and high concentration, model, and control groups. Intracerebroventricular injection of β-amyloid25-35 in C57bl/6 mice caused an impairment of learning and memory. Next day, intragastric administration of procyanidins in the treatment group mice: (lower, middle and high concentration). Hoechst staining observed apoptosis of neuronal nuclei in the hippocampus. Immunohistochemistry determined synaptic rem...περισσότερα »
Low level of low-density lipoprotein cholesterol is related with increased hemorrhagic transformation after acute ischemic cerebral infarction
*OBJECTIVE:* The prevalence of hemorrhagic transformation (HT) after acute ischemic infarction varies greatly. Risk factors of HT include ageing, severity of stroke, baseline hypertension, high NIH Stroke Scale (NIHSS) scores, hyperglycemia and cardioembolic infarction and low levels of low-density lipoprotein (LDL). We investigated the relationship between LDL, lipid profile and HT after acute ischemic infarction and suggested precautions for HT management. *PATIENTS AND METHODS:* Three hundred and forty-eight patients with acute infarction were included in the study. Fasting lip... περισσότερα »
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy: The objective was to determine the incidence of exposure of the lingual branch of the glossopharyngeal nerve during tonsillectomy with a retrospective review of surgical findings in 138 children who underwent total tonsillectomy at a tertiary medical center. Age, sex, surgical indication, tonsil size, congenital abnormalities, operative time, and surgical findings indicating the presence or absence of the glossopharyngeal nerve in the tonsillar fossa were recorded. Statistical analysis was perf... περισσότερα »
Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base
Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base: Objective With the emergence of transoral robotic approaches, head and neck surgeons are faced with an unfamiliar inside-out head and neck anatomy. This study was performed to describe key anatomic landmarks and surgical considerations of transoral robotic resection of the lateral oropharyngeal wall, the parapharyngeal space, and the base of the tongue. Study Design Descriptive transoral anatomic study. Setting Academic anatomy laboratory and tertiary academ...περισσότερα »
Postoperative Complications in Elderly Patients Undergoing Head and Neck Surgery: Opportunities for Quality Improvement
Postoperative Complications in Elderly Patients Undergoing Head and Neck Surgery: Opportunities for Quality Improvement: Objective To assess the frequency and nature of postoperative complications that occur in elderly patients, as compared with younger patients, following head and neck surgery. Study Design Cohort study of national database. Setting American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2013. Subjects and Methods We identified 29,891 patients who had head and neck surgery during the study period and classified them as having upp...περισσότερα »
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy: Objectives The indications for neck dissection concurrent with salvage laryngectomy in the clinically N0 setting remain unclear. Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage laryngectomy cohort. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Patients with persistent or recurrent laryngeal squa...περισσότερα »
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review: Objective Adenoid cystic carcinoma is a malignant minor salivary gland tumor that represents <1% of all laryngeal tumors. The submucosal location of laryngeal adenoid cystic carcinoma (LACC) results in delayed presentation. Here, we present the first systematic review of reported cases of LACC to determine trends in presentation, diagnostic and treatment modalities, and patient outcome. Data Sources PubMed, Web of Science, MEDLINE, and EMBASE databases. Methods A search of the above databases was done to identify articles re... περισσότερα »
Lymph Node Yield as a Predictor of Survival in Pathologically Node Negative Oral Cavity Carcinoma
Lymph Node Yield as a Predictor of Survival in Pathologically Node Negative Oral Cavity Carcinoma: Objective Even after a pathologically node-negative (pN0) neck dissection for oral cavity squamous cell carcinoma (SCC), patients may develop regional recurrence. In this study, we (1) hypothesize that an increased number of lymph nodes removed (lymph node yield) in patients with pN0 oral SCC predicts improved survival and (2) explore predictors of survival in these patients using a multivariable model. Study Design Case series with chart review. Setting Administrative database anal... περισσότερα »
Readability and Understandability of Online Vocal Cord Paralysis Materials
Readability and Understandability of Online Vocal Cord Paralysis Materials: Objective Patients use several online resources to learn about vocal cord paralysis (VCP). The objective of this study was to assess the readability and understandability of online VCP patient education materials (PEMs), with readability assessments and the Patient Education Materials Evaluation Tool (PEMAT), respectively. The relationship between readability and understandability was then analyzed. Study Design and Setting Descriptive and correlational design. Method Online PEMs were identified by perfor... περισσότερα »
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery: Objective Sphenopalatine artery ligation is a commonly employed surgical intervention for control of posterior epistaxis unresponsive to nasal packing. The objective of the present study was to evaluate the outcome of sphenopalatine artery ligation for control of epistaxis at our institution and the impact of timing and other factors on outcome. Study Design Case series with chart review. Setting Academic tertiary referral center. Subjects and Methods Case notes were review... περισσότερα »
Endoscopic Salivary Stone Fragmentation with Pneumatic Lithotripsy in a Simulation Model
Endoscopic Salivary Stone Fragmentation with Pneumatic Lithotripsy in a Simulation Model: Objective To evaluate the endoscopic fragmentation and removal of human salivary stones by employing intracorporeal pneumatic lithotripsy in a clinical simulation model of the submandibular gland. Study Design Simulation model evaluating endoscopic management of human salivary stones. Setting Laboratory. Subjects and Methods A flexible nitinol contact probe adapted to a CO2-driven handheld salivary pneumatic lithotripter was deployed through a sialendoscope to disrupt parotid (n = 1) and su...περισσότερα »
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy: Objective Evidence-based medicine is the gold standard practice model for patient management. Our aim was to determine whether decisions made by pediatric subspecialists regarding management of obstructive sleep apnea in children without tonsillar hypertrophy adhered to this model or were based on clinical experiences. Study Design Single-institution prospective study. Setting Multidisciplinary upper airway center in an academic pediatric hospital. Subjects and Methods Twelve pediatric subsp...περισσότερα »
Bacterial Biofilm in Salivary Gland Stones: Cause or Consequence?
Bacterial Biofilm in Salivary Gland Stones: Cause or Consequence?: Objective The pathogenesis of salivary calculi is not yet clear; however, 2 theories have been formulated: (1) "the classic theory," based on calcium microdeposits in serous and ductal acinous cells, successively discharged into the ducts; (2) "the retrograde theory," based on a retrograde migration of food, bacteria, and so on from the oral cavity to the salivary duct. The aim of the present study is to highlight the role of bacteria and biofilm in stone formation. Study Design Case series without comparison. Sett... περισσότερα »
Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors
*Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors: * [ΑΝΑΦΟΡΑ] Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors. *RL Witt - Otolaryngology--head and neck surgery: official journal …, 2016 - ncbi.nlm.nih.gov* *... Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors. Witt RL(1).Author information: (1)Thomas Jefferson University, Philadelphia, Pennsylvania, USA Universityof Delaware, Newark, Delaware, USA Helen F. Graham Cancer Center, Christiana Care ...*
4D MRI for the Localization of Parathyroid Adenoma
4D MRI for the Localization of Parathyroid Adenoma: A Novel Method in Evolution: The sestamibi scan (MIBI) and ultrasound (US) are used for preoperative localization of parathyroid adenoma (PTA), with sensitivity as high as 90%. We developed 4-dimensional magnetic resonance imaging (4D MRI) as a novel tool for identifying PTAs. Eleven patients with PTA were enrolled. 4D MRI from the mandible to the aortic arch was used. Optimization of the timing of image acquisition was obtained by changing dynamic and static sequences. PTAs were identified in all except 1 patient. In 9 patients, ...περισσότερα »
Endoscopically Assisted Pediatric Cholesteatoma Surgery
Long-term Results of Endoscopically Assisted Pediatric Cholesteatoma Surgery: Objective Routine endoscopic examination during primary surgery decreased the rate of residual cholesteatoma to 18% in our early experience. Based on this, we stopped performing routine second-look surgery in children who were endoscopically free of cholesteatoma at the end of primary surgery. We sought to investigate if second-look procedures after endoscopic-assisted surgery could safely be performed only in children at a high risk of residual disease (extensive inflammation, spontaneously ruptured or f...περισσότερα »
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer: Objectives The effects of socioeconomic status (SES) on the incidence of well-differentiated thyroid cancer (WDTC) are well researched. However, the association between SES and outcomes is not delineated. Our objective was to determine if SES affected outcomes of WDTC. Study Designs Retrospective database review. Setting Tertiary care medical center. Subjects and Methods The Henry Ford Virtual Data Warehouse Tumor Registry was used to identify cases of WDTC. Socioeconomic data were obtained through the ...περισσότερα »
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty: Objective To evaluate the role of tension on the genioglossus muscle in the performance of genioglossus advancement on sleep-disordered breathing in patients undergoing multilevel obstructive sleep apnea (OSA) surgery. Study Design Prospective study. Setting Academic practice. Subjects and Methods Twenty-three subjects underwent genioglossus advancement with uvulopalatopharyngoplasty for OSA. Subjects underwent pre- and postoperative polysomnography, ceph... περισσότερα »
Outcomes for hypopharyngeal carcinoma treated with organ-preservation therapy
Outcomes for hypopharyngeal carcinoma treated with organ-preservation therapy: Abstract Background This study assessed outcomes of patients with hypopharyngeal carcinoma treated with organ-preservation therapy utilizing intensity-modulated radiation therapy (IMRT). Methods The medical records of 98 patients treated with definitive IMRT +/- chemotherapy from 2001 to 2013 for nonmetastatic hypopharyngeal cancer were retrospectively reviewed. Results Patients were treated to doses of 66 to 72 Gy. Eighty-three patients (85%) received chemotherapy. With median follow-up of 35 months, 2-y... περισσότερα »
Extranodal Rosai–Dorfman disease threatening the airway
An unusual presentation of via Auris Nasus Larynx Publication date: April 2016 *Source:*Auris Nasus Larynx, Volume 43, Issue 2 Author(s): Santosh K. Swain, Alok Das, Sangeeta Sahoo, Manas R. Baisakh, Mahesh C. Sahu Rosai–Dorfman disease (RDD) is a rare benign systemic histiocytic proliferation, characterized by massive lymph node enlargement and sometimes associated with extranodal involvement. Even though it is considered as a benign disease, fatalities can occur due to its unusually large size and its location. Our case highlighting a primary extranodal site of vallecula, which is ...περισσότερα »
Combined transcervical and orbitozygomatic approach for the removal of a nasopharyngeal adenocarcinoma
Combined transcervical and orbitozygomatic approach for the removal of a nasopharyngeal adenocarcinoma via Auris Nasus Larynx Publication date: April 2016 *Source:*Auris Nasus Larynx, Volume 43, Issue 2 Author(s): Muneyuki Masuda, Junichi Fukushima, Akiko Fujimura, Hideoki Uryu ObjectiveIn some cases, the exposure and safeguarding of the internal carotid artery (ICA) are not easy by the maxillary swing approach that is used as a mainstay for the removal of nasopharyngeal tumors. To address this issue, we have developed a new combined transcervical and orbitozygomatic approach.MethodsA ... περισσότερα »
Conductive hearing loss with an intact tympanic membrane due to non-inflammatory causes
Conductive hearing loss with an intact tympanic membrane due to non-inflammatory causes via Auris Nasus Larynx Publication date: April 2016 *Source:*Auris Nasus Larynx, Volume 43, Issue 2 Author(s): Jin Hyuk Choi, Min Young Lee, Ji Hye Park, Kyu-Yup Lee, Sang Heun Lee, Jeong Hun Jang ObjectiveWe analyzed audiologic and surgical findings in patients with conductive hearing loss (CHL) with an intact tympanic membrane (TM) that was of a non-inflammatory origin.MethodsWe reviewed data from patients who underwent exploratory tympanotomy for CHL with intact TM from January 1995 to November ... περισσότερα »
Cetuximab in recurrent/metastatic disease of squamous cell carcinoma of head and neck
*Emergence of long-term surviving patients with the introduction of * *via ScienceDirect Publication: Oral Oncology* *Publication date: Available online 28 February 2016Source:Oral OncologyAuthor(s): Jenniffer Linares, Antonio Rullan, Miren Taberna, Silvia Vazquez, Ricard Mesia* *[HTML] από oraloncology.com* A pilot study of *cetuximab *and the hedgehog inhibitor IPI-926 in *recurrent*/*metastatic head*and *neck squamous cell carcinoma* *DW Bowles, SB Keysar, JR Eagles, G Wang… - Oral oncology, 2016 - Elsevier* *... A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in r...περισσότερα »
Determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative
RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization via ScienceDirect Publication: Oral Oncology Publication date: April 2016 *Source:*Oral Oncology, Volume 55 Author(s): Lisa M. Rooper, Manoj Gandhi, Justin A. Bishop, William H. Westra ObjectivesEvaluation of human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) has become increasingly important for prognosticati... περισσότερα »
Polymorphous low-grade adenocarcinoma
: A Danish national study via ScienceDirect Publication: Oral Oncology Publication date: April 2016 *Source:*Oral Oncology, Volume 55 Author(s): Mohammad Talal Elhakim, Helle Breinholt, Christian Godballe, Lisbeth Juhler Andersen, Hanne Primdahl, Claus A. Kristensen, Kristine Bjørndal ObjectivesTo present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors.Materials and methodsBy merging three Danish nationwide registries, 73 patients diagnosed with PLGA from 1990 to 2005 were identified. Histologic... περισσότερα »
Patients’ lived experiences regarding maintaining dignity
Patients’ lived experiences regarding maintaining dignity: Preservation of dignity is frequently emphasized as a basic patient’s right in national and international nursing codes of ethics and is indeed the essence and core of nursing care. It is therefore essential to explore the concept based on patients’ lived experiences in order to maintain and respect their dignity and consequently improve the quality of health services and patient satisfaction. The present study aimed to discover the lived experiences of Iranian patients regarding maintaining their dignity at the bedside. ... περισσότερα »
Developing an ethical guideline for clinical teaching in an University ofMedical Sciences
Developing an ethical guideline for clinical teaching in Tehran University ofMedical Sciences: Clinical education is an essential part of medical trainees’ education process, and curriculum planners agree that it should be based on ethical standards and principles in the medical field. Nevertheless, no explained and codified criteria have been developed for ethics in clinical teaching. This study was aimed to develop an ethical guideline for medical students and teachers as the first and most important step in respecting patients' rights in educational centers. The initial draft ... περισσότερα »
Moral self-concept and moral sensitivity in nurses
Moral self-concept and moral sensitivity in Iranian nurses: Nurses are often faced with serious situations that require high levels of legal and ethical knowledge, and should therefore be sensitive to the moral issues in their profession in the decision making process. Some studies have investigated nurses’ moral self-concept as an effective factor in moral sensitivity, but there is not sufficient evidence to support this. The purpose of this study was to determine the correlation between moral sensitivity and moral self-concept in nurses employed in the teaching hospitals in Zahe... περισσότερα »
Ethical challenges in the neonatal intensive care units: perceptions of physicians and nurses
Ethical challenges in the neonatal intensive care units: perceptions of physicians and nurses; an Iranian experience: The challenging nature of neonatal medicine today is intensified by modern advances in intensive care and treatment of sicker neonates. These developments have caused numerous ethical issues and conflicts in ethical decision-making. The present study surveyed the challenges and dilemmas from the viewpoint of the neonatal intensive care personnel in the teaching hospitals of Tehran University of Medical Sciences (TUMS) in the capital of Iran. In this comparative c... περισσότερα »
Professionalism in residents of physical medicine and rehabilitation
Professionalism in residents of physical medicine and rehabilitation in Iran: Professionalism is the foundation of trust on which the doctor-patient relationship is built. This study was performed to measure professionalism in Iranian physical medicine and rehabilitation residents as a baseline assessment tool for future studies. This was a descriptive study. The Persian version of the American Board of Internal Medicine (ABIM) questionnaire was distributed among all the second and third-year residents of the medical state universities of Iran (n=43). Data were summarized as mean... περισσότερα »
Moral distress and perception of futile care in intensive care nurses
Moral distress and perception of futile care in intensive care nurses: Special characteristics of care environments have always presented nurses with some challenges. One particular situation is futile care, which is frequently accompanied by countless moral and legal challenges. The dominant atmosphere in futile care may cause moral distress to nurses and lead to a sense of guilt, pain, suffering, job dissatisfaction, and eventually cause nurses to leave the job. This descriptive-analytical study attempted to investigate the relationship between futile care and moral distress in ... περισσότερα »
Perception of professional ethics by therapists working with children
Perception of professional ethics by Iranian occupational therapists working with children: Ethics are related to the structure and culture of the society. In addition to specialized ethics for every profession, individuals also hold their own personal beliefs and values. This study aimed to investigate Iranian occupational therapists’ perception of ethical practice when working with children. For this purpose, qualitative content analysis was used and semi-structured interviews were conducted with ten occupational therapists in their convenient place and time. Each interview was ... περισσότερα »
Questionnaires that screen for multiple SLEEP disorders
Questionnaires that screen for multiple SLEEP disorders: The goal of this review was to identify, describe, and evaluate the existing multiple sleep disorders screening questionnaires for their comprehensiveness, brevity, and psychometric quality. A systematic review was conducted using Medline/PubMed, Cumulative Index to Nursing & Allied Health Literature, Health and Psychosocial Instruments and the “grey literature”. Search terms were “sleep disorders, screening, questionnaires, and psychometrics”. The scope of the search was limited to English language articles for adult age grou...περισσότερα »
Guided bone regeneration in osteoporotic conditions following treatment with zoledronic acid
Guided bone regeneration in osteoporotic conditions following treatment with zoledronic acid: Abstract Objectives To evaluate new bone formation in calvarial critical size defects (CSD) under dense polytetrafluoroethylene (d-PTFE), microporous membranes for guided bone regeneration (GBR) in healthy, osteoporotic and osteoporotic treated with zoledronic acid (ZA) rats. Methods Forty-eight, female, 6-month old Wistar rats were included in the study. Osteoporosis was induced by ovariectomy (OVX) and calcium-deficient diet in 32 rats. Sixteen OVX rats were treated with a single dose of ... περισσότερα »
Antimicrobials Influence Bond Stiffness and Detachment of Oral Bacteria
Antimicrobials Influence Bond Stiffness and Detachment of Oral Bacteria: Oral biofilm can never be fully removed by oral hygiene measures. Biofilm left behind after brushing is often left behind on the same sites and exposed multiple times to antimicrobials from toothpastes and mouthrinses, after which removal becomes increasingly difficult. On the basis of this observation, we hypothesize that oral bacteria adhering to salivary conditioning films become more difficult to remove after adsorption of antimicrobials due to stiffening of their adhesive bond. To verify this hypothesis, ... περισσότερα »
Dynamic hyperarticulation of coda voicing contrasts
Dynamic hyperarticulation of coda voicing contrasts: [image: cm_sbs_024_plain.png] This study investigates the capacity for targeted hyperarticulation of contextually-relevant contrasts. Participants communicated target words with final /s/ or /z/ when a voicing minimal-pair (e.g., target dose, minimal-pair doze) either was or was not available as an alternative in the context. The results indicate that talkers enhance the durational cues associated with the word-final voicing contrast based on whether the context requires it, and that this can involve both elongation as well as s... περισσότερα »
Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.
Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.: Cell Death Differ. 2016 Feb 26; Authors: Chen JR, Tang ZH, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF Abstract Deafness or hearing loss is a major issue in human health. Inner ear hair cells are the main sensory receptors responsible for hearing. Defects in hair cells are one of the major causes of deafness. A combination of induced pluripotent stem cell (iPSC) technology with genome-edit... περισσότερα »
The case for earlier cochlear implantation in postlingually deaf adults
The case for earlier cochlear implantation in postlingually deaf adults: 10.3109/14992027.2015.1128125<br>Richard C. Dowell Abstract *Objective*: This paper aimed to estimate the difference in speech perception outcomes that may occur due to timing of cochlear implantation in relation to the progression of hearing loss. *Design*: Data from a large population-based sample of adults with acquired hearing loss using cochlear implants (CIs) was used to estimate the effects of duration of hearing loss, age, and pre-implant auditory skills on outcomes for a hypothetical standard patie... περισσότερα »
Exploration of a physiologically-inspired hearing-aid algorithm using a computer model mimicking impaired hearing
Exploration of a physiologically-inspired hearing-aid algorithm using a computer model mimicking impaired hearing: 10.3109/14992027.2015.1135352<br>Tim Jürgens Abstract *Objective*: To use a computer model of impaired hearing to explore the effects of a physiologically-inspired hearing-aid algorithm on a range of psychoacoustic measures.*Design*: A computer model of a hypothetical impaired listener’s hearing was constructed by adjusting parameters of a computer model of normal hearing. Absolute thresholds, estimates of compression, and frequency selectivity (summarized to a hear...περισσότερα »
Motivational engagement in first-time hearing aid users: A feasibility study
Motivational engagement in first-time hearing aid users: A feasibility study: 10.3109/14992027.2015.1133935<br>Melanie Ferguson Abstract *Objective*: To assess (1) the feasibility of incorporating the Ida Institute’s Motivation Tools into a UK audiology service, (2) the potential benefits of motivational engagement in first-time hearing aid users, and (3) predictors of hearing aid and general health outcome measures. *Design*: A feasibility study using a single-centre, prospective, quasi-randomized controlled design with two arms. The Ida Institute’s Motivation Tools formed the b... περισσότερα »
Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 28 February 2016 Source:Experimental Cell Research Author(s): Yiqian Chen, Margaret G Gall, Hui Zhang, Fiona M Keane, Geoffrey W McCaughan, Denise MT Yu, Mark D Gorrell The success of dipeptidyl peptidase 4 (DPP4) inhibition as a type 2 diabetes therapy has encouraged deeper examination of the post-proline DPP enzymes. DPP9 has […]
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity via Hearing Research [image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of ... περισσότερα »
Impression cytological study for ocular surface disorders of late stage eye burns
*OBJECTIVE:* This study aims to explore the ocular surface of late stage eye burns by impression cytology (IC) and analyze the cytological changes and their relationship to ocular surface abnormalities. *PATIENTS AND METHODS:* 68 eyes with late stage eye burns (thermal burn: 28 eyes; alkali burn: 26 eyes; acid burn: 14 eyes), procured from 68 patients (aged ranges from 17 to 70 years old). Ocular surface abnormalities were assessed under slit lamp and graded. These were broadly classified as eyelid, corneal, conjunctival, and tear film abnormalities. Impression cytological examina...περισσότερα »
A correlation between selenium and carnitine levels with Hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients
*OBJECTIVE:* The hypo-osmotic swelling (HOS) test predicts membrane integrity by determining the ability of the sperm membrane to maintain equilibrium between the sperm cell and its environment. The aim of our study was to determine the correlation between selenium and carnitine levels in the seminal fluid with HOS test for sperm membrane in low-grade varicocele patients. *PATIENTS AND METHODS:* Study numbered 64 examinees who suffered from low-grade varicocele and were divided into two groups, according to fertility potential and HOS test outcome. The study also included a contro...περισσότερα »
Effect of complete hilar versus only renal artery clamping on renal histomorphology following ischemia/reperfusion injury in an experimental model
*OBJECTIVE:* To evaluate the effect of temporary complete hilar versus only renal artery clamping with different duration of warm ischemia on renal functions, and possibly identify a "safe" clamping type and duration of renal ischemia. *MATERIALS AND METHODS:* Fifty male rabbits have been incorporated to study. Rabbits were subjected to ischemia/reperfusion injury by temporary vascular clamping. Reagents were randomized to 3 experimental groups (only renal artery clamping, complete hilar clamping, sham surgery) and sub-groups were determined according to different clamping times (... περισσότερα »
Mutations reducing replication from R-loops suppress the defects of growth, chromosome segregation and DNA supercoiling in cells lacking topoisomerase I and RNase HI activity
Publication date: Available online 27 February 2016 *Source:*DNA Repair Author(s): Valentine Usongo, Makisha Martel, Aurélien Balleydier, Marc Drolet R-loop formation occurs when the nascent RNA hybridizes with the template DNA strand behind the RNA polymerase. R-loops affect a wide range of cellular processes and their use as origins of replication was the first function attributed to them. In E. coli, R-loop formation is promoted by the ATP-dependent negative supercoiling activity of gyrase (gyrA and gyrB) and is inhibited by topoisomerase (topo) I (topA) relaxing transcription-i... περισσότερα »
Cross-Modal Transfer of Statistical Information Benefits from Sleep
Publication date: Available online 27 February 2016 *Source:*Cortex Author(s): Simon J. Durrant, Dr Scott A. Cairney, Dr Penelope A. Lewis Extracting regularities from a sequence of events is essential for understanding our environment. However, there is no consensus regarding the extent to which such regularities can be generalised beyond the modality of learning. One reason for this could be the variation in consolidation intervals used in different paradigms, also including an opportunity to sleep. Using a novel statistical learning paradigm in which structured information is acq... περισσότερα »
Editorial Board/Title Page
Publication date: March 2016 *Source:*Cortex, Volume 76 from #Medicine via ola Kala on Inoreader http://ift.tt/1Qcdr9X via IFTTT
Contralesional distractors enhance ipsilesional target processing after right-hemispheric stroke
Publication date: Available online 27 February 2016 *Source:*Cortex Author(s): Simone Vossel, Gereon R. Fink Stroke can result in marked impairments in the processing of information presented in contralesional space. The present prospective study investigated how a contralesional distractor affects ipsilesional perception in patients with a right-hemispheric stroke. In a simple target detection task, the influence of the distractor on reaction times was examined in stroke patients and compared to the performance of healthy elderly controls. Distractor interference effects were relat... περισσότερα »
A third-person perspective on co-speech action gestures in Parkinson’s disease
Publication date: Available online 27 February 2016 *Source:*Cortex Author(s): Stacey Humphries, Judith Holler, Trevor J. Crawford, Elena Herrera, Ellen Poliakoff A combination of impaired motor and cognitive function in Parkinson's disease (PD) can impact on language and communication, with patients exhibiting a particular difficulty processing action verbs. Co-speech gestures embody a link between action and language and contribute significantly to communication in healthy people. Here, we investigated how co-speech gestures depicting actions are affected in PD, in particular with... περισσότερα »
Role of features and categories in the organization of object knowledge: Evidence from adaptation fMRI
Publication date: Available online 6 February 2016 *Source:*Cortex Author(s): Jingyi Geng, Tatiana T. Schnur There are two general views regarding the organization of object knowledge. The feature-based view assumes that object knowledge is grounded in a widely distributed neural network in terms of sensory/function features (e.g., Warrington & Shallice, 1984), while the category-based view assumes in addition that object knowledge is organized by taxonomic and thematic categories (e.g., Schwartz et al., 2011). Using an functional magnetic resonance imaging (fMRI) adaptation paradig...περισσότερα »
Emotional caricatures in frontotemporal dementia
Publication date: March 2016 *Source:*Cortex, Volume 76 Author(s): Camilla N. Clark, Jason D. Warren from #Medicine via ola Kala on Inoreader http://ift.tt/1QcdqTp via IFTTT
Cover Figure
Publication date: March 2016 *Source:*Cortex, Volume 76 from #Medicine via ola Kala on Inoreader http://ift.tt/1QPefFc via IFTTT
Protective effects of elafin against adult asthma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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The morbidity and cost of vocal cord dysfunction misdiagnosed as asthma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Editorial: All that wheezes is not asthma, and all that itches is not allergy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Approach to evaluation and management of a patient with multiple food allergies
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Beclomethasone Dipropionate Nasal Aerosol in Patients with Perennial Allergic Rhinitis (BALANCE) study: 6-month results
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Respiratory disease in the Asia-Pacific region: Cough as a key symptom
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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Evaluation of allergic sensitivity to Acanthamoeba allergen in patients with chronic cough
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
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HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of cell protection, inflammatory responses, cell differentiation, effects of hypox... περισσότερα »
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post morte...περισσότερα »
Changes in the publication of Neurocirugía.
[Changes in the publication of Neurocirugía]. Neurocirugia (Astur). 2016 Jan-Feb;27(1):1 Authors: Lagares A, Fernández Alén JA, Comité de Redacción PMID: 26915752 [PubMed – in process] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Ln1M95 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LN8Wyv via IFTTT
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic… Continue reading HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human… Continue reading Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic… Continue reading HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human… Continue reading Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human… Continue reading Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Publication date: Available online 27 February 2016 Source:Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic… Continue reading HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas
Abstract High-altitude adaptation in Tibetans is influenced by introgression of a 32.7-kb haplotype from the Denisovans, an extinct branch of archaic humans, lying within the endothelial PAS domain protein 1 (EPAS1), and has also been reported in Sherpa. We genotyped 19 variants in this genomic region in 1507 Eurasian individuals, including 1188 from Bhutan and… Continue reading Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas
Naproxen, a Nonsteroidal Anti-Inflammatory Drug Can Affect Daily Hypobaric Hypoxia-Induced Alterations of Monoamine Levels in Different Areas of the Brain in Male Rats
High Altitude Medicine & Biology , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1PXBdE7 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QEyoau via IFTTT
Target maneuver discrimination using ISAR image in interception
Discrimination for target maneuver magnitude and direction switching during the endgame is significant for interception performance improvement. Inverse synthetic aperture radar (ISAR) images carry the informa… from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1SQT6KG via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OEPynb via IFTTT
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of cell protection, inflammatory responses, cell differentiation, effects of hypox... περισσότερα »
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post morte...περισσότερα »
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of cell protection, inflammatory responses, cell differentiation, effects of hypox... περισσότερα »
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post morte...περισσότερα »
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of cell protection, inflammatory responses, cell differentiation, effects of hypox... περισσότερα »
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post morte...περισσότερα »
Perception of professional ethics by Iranian occupational therapists working with children
Ethics are related to the structure and culture of the society. In addition to specialized ethics for every profession, individuals also hold their own personal beliefs and values. This study aimed to investigate Iranian occupational therapists' perception of ethical practice when working with children. For this purpose, qualitative content analysis was used and semi-structured interviews were conducted with ten occupational therapists in their convenient place and time. Each interview was transcribed and double-checked by the research team. Units of meaning were extracted from e... περισσότερα »
A Review of Ferdous al-Hekma fil-Tibb by Ali ibn Raban Tabari
T Ferdous al-Hekma (Paradise of Wisdom) is one of the oldest medical texts in the Islamic world written in Arabic in 850 AD by Ali ibn Raban Tabari. He was a Persian physician who moved from Tabaristan (Mazandaran province of modern day Iran) to Samarra during the reign of the Abbasid Caliph al-Mutawakkil (847-861 AD). We studied the book of Ferdous al-Hekma fil-Tibb, in an attempt to comprehend its general outlook on diseases of different organs, their classifications and the associated signs and symptoms. The book is one of the earliest medical pandects of the period of transla... περισσότερα »
Moral distress and perception of futile care in intensive care nurses
Special characteristics of care environments have always presented nurses with some challenges. One particular situation is futile care, which is frequently accompanied by countless moral and legal challenges. The dominant atmosphere in futile care may cause moral distress to nurses and lead to a sense of guilt, pain, suffering, job dissatisfaction, and eventually cause nurses to leave the job. This descriptive-analytical study attempted to investigate the relationship between futile care and moral distress in intensive care nurses. Study subjects were 300 nurses in intensive care... περισσότερα »
Chorasmia Medical School from the beginning until the Mongol invasion
In research on the history of medicine, less attention is paid to the subject of historical geography*.* Considering the importance of this subject in the history of science, this paper discusses one of the most important science centers in the world. This outstanding medical research center was located in *Gorganch* city, *Chorasmia* area, in the Eastern part of the Islamic. Chorasmia medical school was one of the important Iranian medical schools before the Mongols' attack. Its history (305-1231 A.D.) can be divided into three eras; Ale Iraq, Ale Ma'mun, and era of the Khwarazmi... περισσότερα »
Professionalism in residents of physical medicine and rehabilitation in Iran
Professionalism is the foundation of trust on which the doctor-patient relationship is built. This study was performed to measure professionalism in Iranian physical medicine and rehabilitation residents as a baseline assessment tool for future studies. This was a descriptive study. The Persian version of the American Board of Internal Medicine (ABIM) questionnaire was distributed among all the second and third-year residents of the medical state universities of Iran (n=43). Data were summarized as mean (SD), and independent samples t-test was used for comparison of means between... περισσότερα »
Ethical challenges in the neonatal intensive care units: perceptions of physicians and nurses; an Iranian experience
The challenging nature of neonatal medicine today is intensified by modern advances in intensive care and treatment of sicker neonates. These developments have caused numerous ethical issues and conflicts in ethical decision-making. The present study surveyed the challenges and dilemmas from the viewpoint of the neonatal intensive care personnel in the teaching hospitals of Tehran University of Medical Sciences (TUMS) in the capital of Iran. In this comparative cross-sectional study conducted between March 2013 and February 2014, the physicians' and nurses' perceptions of the e... περισσότερα »
Moral self-concept and moral sensitivity in Iranian nurses
Nurses are often faced with serious situations that require high levels of legal and ethical knowledge, and should therefore be sensitive to the moral issues in their profession in the decision making process. Some studies have investigated nurses' moral self-concept as an effective factor in moral sensitivity, but there is not sufficient evidence to support this. The purpose of this study was to determine the correlation between moral sensitivity and moral self-concept in nurses employed in the teaching hospitals in Zahedan, Iran. This cross-sectional descriptive study aimed to ... περισσότερα »
Surveying the attitudes of transsexual patients referring to Tehran Institute of Psychiatry toward doctors’ empathy, Iran, 2011-2012
Physicians' knowledge of therapy and counseling stands among the most important issues in the viewpoints of clients who refer to psychiatric centers. Transsexual patients are very important in this regard. The goal of this research is to study their attitude toward doctors' empathy. A group of transsexual patients who referred to the Tehran Institute of Psychiatry, Iran, answered the Jefferson Scale of Empathy. The relationship of the patients' age, gender, education level, and lifestyle with their attitude was measured. This study was conducted on 40 patients, including 16 women ... περισσότερα »
Developing an ethical guideline for clinical teaching in Tehran University ofMedical Sciences
Clinical education is an essential part of medical trainees' education process, and curriculum planners agree that it should be based on ethical standards and principles in the medical field. Nevertheless, no explained and codified criteria have been developed for ethics in clinical teaching. This study was aimed to develop an ethical guideline for medical students and teachers as the first and most important step in respecting patients' rights in educational centers. The initial draft included the codes of ethics in clinical education and was developed based on library studies. ... περισσότερα »
Development of a scale for the evaluation of patients’ rights prerequisites at educational hospitals in Iran: a study using the Delphi technique
The patients' rights status is one of the essential elements in defining norms related to the concept of clinical governance system. In addition, the patients' rights status is an important index for quality of care offered in the health care system. However, the lack of a coherent instrument makes it difficult to evaluate patients' rights status in hospitals and clinics. The aim of this study was to develop an instrument for the evaluation of patients' rights prerequisites at educational hospitals in Iran. This study was conducted using the modified Delphi technique. In this stu... περισσότερα »
Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas
Abstract High-altitude adaptation in Tibetans is influenced by introgression of a 32.7-kb haplotype from the Denisovans, an extinct branch of archaic humans, lying within the endothelial PAS domain protein 1 (*EPAS1*), and has also been reported in Sherpa. We genotyped 19 variants in this genomic region in 1507 Eurasian individuals, including 1188 from Bhutan and Nepal residing at altitudes between 86 and 4550 m above sea level. Derived alleles for five SNPs characterizing the core Denisovan haplotype (AGGAA) were present at high frequency not only in Tibetans and Sherpa, but also ... περισσότερα »
HEI-OC1 Cells as a Model for Investigating Drug Cytotoxicity
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Gilda Kalinec, Pru Thein, Channy Park, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathways, autophagy and senescence, mechanism of cell protection, inflammatory responses, cell differentiation, effects of hypox... περισσότερα »
Human Audiometric Thresholds do not Predict Specific Cellular Damage in the Inner Ear
[image: alertIcon.gif] Publication date: Available online 27 February 2016 *Source:*Hearing Research Author(s): Lukas D. Landegger, Demetri Psaltis, Konstantina M. Stankovic IntroductionAs otology enters the field of gene therapy and human studies commence, the question arises whether audiograms – the current gold standard for the evaluation of hearing function – can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post morte...περισσότερα »
Protective effects of elafin against adult asthma
from #ENT via xlomafota13 on Inoreader http://ift.tt/1Ql83Tf via IFTTT
The morbidity and cost of vocal cord dysfunction misdiagnosed as asthma
from #ENT via xlomafota13 on Inoreader http://ift.tt/1OETpAA via IFTTT
Editorial: All that wheezes is not asthma, and all that itches is not allergy
from #ENT via xlomafota13 on Inoreader http://ift.tt/1Ql861g via IFTTT
Approach to evaluation and management of a patient with multiple food allergies
from #ENT via xlomafota13 on Inoreader http://ift.tt/1OETnsm via IFTTT
SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis
from #ENT via xlomafota13 on Inoreader http://ift.tt/1Ql85KI via IFTTT
The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis
from #ENT via xlomafota13 on Inoreader http://ift.tt/1OETnbX via IFTTT
Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy
from #ENT via xlomafota13 on Inoreader http://ift.tt/1Ql835t via IFTTT
Beclomethasone Dipropionate Nasal Aerosol in Patients with Perennial Allergic Rhinitis (BALANCE) study: 6-month results
from #ENT via xlomafota13 on Inoreader http://ift.tt/1OETmVr via IFTTT
Respiratory disease in the Asia-Pacific region: Cough as a key symptom
from #ENT via xlomafota13 on Inoreader http://ift.tt/1Ql82yx via IFTTT
Evaluation of allergic sensitivity to Acanthamoeba allergen in patients with chronic cough
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Th1/Th2/Th17 cells imbalance in patients with asthma with and without psychological symptoms
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Parental perception of efficacy of antihistamines for pruritus in pediatric atopic dermatitis
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Risk of thromboembolism in patients with hereditary angioedema treated with plasma-derived C1-inhibitor
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Chronic pruritic dermatitis and peripheral eosinophilia in a 42-year-old man
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For the Patient
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Botulinum toxin in the treatment of orofacial pain
Publication date: Available online 27 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Adrián Curto from #ENT via xlomafota13 on Inoreader http://ift.tt/1LN43FH via IFTTT
Supermicrosurgery simulation using prosthetic lymphatic channels
Publication date: Available online 27 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): C. Tsunashima, R. Kannan, I. Koshima from #ENT via xlomafota13 on Inoreader http://ift.tt/1ph71xo via IFTTT
Perception of professional ethics by Iranian occupational therapists working with children
Ethics are related to the structure and culture of the society. In addition to specialized ethics for every profession, individuals also hold their own personal beliefs and values. This study aimed to investigate Iranian occupational therapists' perception of ethical practice when working with children. For this purpose, qualitative content analysis was used and semi-structured interviews were conducted with ten occupational therapists in their convenient place and time. Each interview was transcribed and double-checked by the research team. Units of meaning were extracted from e... περισσότερα »
A Review of Ferdous al-Hekma fil-Tibb by Ali ibn Raban Tabari
T Ferdous al-Hekma (Paradise of Wisdom) is one of the oldest medical texts in the Islamic world written in Arabic in 850 AD by Ali ibn Raban Tabari. He was a Persian physician who moved from Tabaristan (Mazandaran province of modern day Iran) to Samarra during the reign of the Abbasid Caliph al-Mutawakkil (847-861 AD). We studied the book of Ferdous al-Hekma fil-Tibb, in an attempt to comprehend its general outlook on diseases of different organs, their classifications and the associated signs and symptoms. The book is one of the earliest medical pandects of the period of transla... περισσότερα »
Moral distress and perception of futile care in intensive care nurses
Special characteristics of care environments have always presented nurses with some challenges. One particular situation is futile care, which is frequently accompanied by countless moral and legal challenges. The dominant atmosphere in futile care may cause moral distress to nurses and lead to a sense of guilt, pain, suffering, job dissatisfaction, and eventually cause nurses to leave the job. This descriptive-analytical study attempted to investigate the relationship between futile care and moral distress in intensive care nurses. Study subjects were 300 nurses in intensive care... περισσότερα »
Chorasmia Medical School from the beginning until the Mongol invasion
In research on the history of medicine, less attention is paid to the subject of historical geography*.* Considering the importance of this subject in the history of science, this paper discusses one of the most important science centers in the world. This outstanding medical research center was located in *Gorganch* city, *Chorasmia* area, in the Eastern part of the Islamic. Chorasmia medical school was one of the important Iranian medical schools before the Mongols' attack. Its history (305-1231 A.D.) can be divided into three eras; Ale Iraq, Ale Ma'mun, and era of the Khwarazmi... περισσότερα »
Professionalism in residents of physical medicine and rehabilitation in Iran
Professionalism is the foundation of trust on which the doctor-patient relationship is built. This study was performed to measure professionalism in Iranian physical medicine and rehabilitation residents as a baseline assessment tool for future studies. This was a descriptive study. The Persian version of the American Board of Internal Medicine (ABIM) questionnaire was distributed among all the second and third-year residents of the medical state universities of Iran (n=43). Data were summarized as mean (SD), and independent samples t-test was used for comparison of means between... περισσότερα »
Ethical challenges in the neonatal intensive care units: perceptions of physicians and nurses; an Iranian experience
The challenging nature of neonatal medicine today is intensified by modern advances in intensive care and treatment of sicker neonates. These developments have caused numerous ethical issues and conflicts in ethical decision-making. The present study surveyed the challenges and dilemmas from the viewpoint of the neonatal intensive care personnel in the teaching hospitals of Tehran University of Medical Sciences (TUMS) in the capital of Iran. In this comparative cross-sectional study conducted between March 2013 and February 2014, the physicians' and nurses' perceptions of the e... περισσότερα »
Moral self-concept and moral sensitivity in Iranian nurses
Nurses are often faced with serious situations that require high levels of legal and ethical knowledge, and should therefore be sensitive to the moral issues in their profession in the decision making process. Some studies have investigated nurses' moral self-concept as an effective factor in moral sensitivity, but there is not sufficient evidence to support this. The purpose of this study was to determine the correlation between moral sensitivity and moral self-concept in nurses employed in the teaching hospitals in Zahedan, Iran. This cross-sectional descriptive study aimed to ... περισσότερα »
Surveying the attitudes of transsexual patients referring to Tehran Institute of Psychiatry toward doctors’ empathy, Iran, 2011-2012
Physicians' knowledge of therapy and counseling stands among the most important issues in the viewpoints of clients who refer to psychiatric centers. Transsexual patients are very important in this regard. The goal of this research is to study their attitude toward doctors' empathy. A group of transsexual patients who referred to the Tehran Institute of Psychiatry, Iran, answered the Jefferson Scale of Empathy. The relationship of the patients' age, gender, education level, and lifestyle with their attitude was measured. This study was conducted on 40 patients, including 16 women ... περισσότερα »
Developing an ethical guideline for clinical teaching in Tehran University ofMedical Sciences
Clinical education is an essential part of medical trainees' education process, and curriculum planners agree that it should be based on ethical standards and principles in the medical field. Nevertheless, no explained and codified criteria have been developed for ethics in clinical teaching. This study was aimed to develop an ethical guideline for medical students and teachers as the first and most important step in respecting patients' rights in educational centers. The initial draft included the codes of ethics in clinical education and was developed based on library studies. ... περισσότερα »
Should People with Patent Foramen Ovale Go to High Altitude? A Case Report of an Alpinist with a Patent Foramen Ovale Exposed to Extreme Altitude
High Altitude Medicine & Biology , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1QdqSaU via IFTTT
Naproxen, a Nonsteroidal Anti-Inflammatory Drug Can Affect Daily Hypobaric Hypoxia-Induced Alterations of Monoamine Levels in Different Areas of the Brain in Male Rats
High Altitude Medicine & Biology , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1PXBdE7 via IFTTT
New horizons for targeted treatment of neuroendocrine tumors.
*New horizons for targeted treatment of neuroendocrine tumors.* Future Oncol. 2016 Feb 26; Authors: Mangano A, Lianos GD, Roukos DH, Mason SE, Kim HY, Dionigi G Abstract Neuroendocrine tumors (NETs) are rare and heterogeneous tumors and there is a paucity of randomized clinical trials evaluating the different therapeutic strategies. Over recent years, some important molecular aspects have been investigated and multiple targeted therapies are currently available. One of the most promising targets for the therapy of NETs are the mTOR and angiogenic growth factor receptors. The adven...περισσότερα »
Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).
*Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).* Ann Hematol. 2016 Feb 26; Authors: Appelmann I, Kreher S, Parmentier S, Wolf HH, Bisping G, Kirschner M, Bergmann F, Schilling K, Brümmendorf TH, Petrides PE, Tiede A, Matzdorff A, Griesshammer M, Riess H, Koschmieder S Abstract Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN)... περισσότερα »
The Problem Is Not What to Do with Indolent and Harmless Prostate Cancer-The Problem Is How to Avoid Finding These Cancers.
*The Problem Is Not What to Do with Indolent and Harmless Prostate Cancer-The Problem Is How to Avoid Finding These Cancers.* Eur Urol. 2016 Feb 22; Authors: Gandaglia G, Briganti A, Fossati N, Salonia A, Mottrie A, Catto J, Montorsi F Abstract One of the most effective ways to reduce overtreatment of prostate cancer is to limit its detection in men with low-risk disease. Although many data are currently missing, we foresee a future with reduced prostate-specific antigen (PSA) testing in men selected through baseline PSA values or genetic predisposition. Then selective biopsy usi... περισσότερα »
Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma.
*Correlation between S-1 treatment outcome and expression of biomarkers for refractory thymic carcinoma.* BMC Cancer. 2016;16(1):156 Authors: Okuma Y, Hosomi Y, Miyamoto S, Shibuya M, Okamura T, Hishima T Abstract BACKGROUND: Thymic carcinoma is a rare cancer with minimal evidence of a survival benefit following chemotherapy. An oral fluoropyrimidine of S-1, however, is the recommended active cytotoxic chemotherapy agent for refractory thymic carcinoma based on a case series, whereas sunitinib or everolimus are recommended as molecular-targeted agents based on Phase II trials. We... περισσότερα »
Botulinum toxin in the treatment of orofacial pain
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 27 February 2016 Source:Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Adrián Curto from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1LN43FH via IFTTT
Supermicrosurgery simulation using prosthetic lymphatic channels
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 27 February 2016 Source:Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): C. Tsunashima, R. Kannan, I. Koshima from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ph71xo via IFTTT
Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1K4d55Q via IFTTT
Polymorphous low-grade adenocarcinoma: A Danish national study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:Oral Oncology, Volume 55 Author(s): Mohammad Talal Elhakim, Helle Breinholt, Christian Godballe, Lisbeth Juhler Andersen, Hanne Primdahl, Claus A. Kristensen, Kristine Bjørndal ObjectivesTo present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors.Materials and methodsBy merging three Danish nationwide registries, 73 patients […]
RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:Oral Oncology, Volume 55 Author(s): Lisa M. Rooper, Manoj Gandhi, Justin A. Bishop, William H. Westra ObjectivesEvaluation of human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) has become increasingly important for prognostication and clinical trial enrollment. This assessment is confounded in OPSCCs that are p16 positive by immunohistochemistry (IHC) […]
Emergence of long-term surviving patients with the introduction of Cetuximab in recurrent/metastatic disease of squamous cell carcinoma of head and neck
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 28 February 2016 Source:Oral Oncology Author(s): Jenniffer Linares, Antonio Rullan, Miren Taberna, Silvia Vazquez, Ricard Mesia from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1LmQou4 via IFTTT
Towards a pragmatic human migraine model for drug testing: 2. Isosorbide-5-mononitrate in healthy individuals
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background A model for the testing of novel anti-migraine drugs should preferably use healthy volunteers for ease of recruiting. Isosorbide-5-mononitrate (5-ISMN) provokes headache in healthy volunteers with some migraine features such as pulsating pain quality and aggravation by physical activity. Therefore, this headache might respond to sumatriptan, a requirement for validation of any model. The […]
May headache triggered by odors be regarded as a differentiating factor between migraine and other primary headaches?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The objective of this article is to characterize olfactory stimulation as a trigger of headaches attacks and differentiation between migraine and other primary headaches. Participants and methods The study was prospective and experimental, with comparison of groups. A total of 158 volunteers (73 men and 85 women) were diagnosed with primary headaches, according to […]
Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
High mobility group box 1 (HMGB1) is a prototypic alarmin or damage-associated molecule inducing inflammatory mediator release and immune response. Several studies have revealed the prognostic and predictive importance of tumor-infiltrating lymphocytes (TILs) in breast cancer. The present study analyzed the expression of HMGB1 in each breast cancer subtype and the relationship between the expression […]
Multiple symmetric lipomatosis with spindle cell proliferation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1pgWdiM via IFTTT
Chinese Journal of Stomatological Research(Electronic Version), Year 2015, Issue 06 -New Issue Alert.
From: order@email.oriprobe.com Date: February 28, 2016 at 08:01AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Stomatological Research(Electronic Version). Year 2015 Issue 06 is now available on CAOD. In this issue: Esthetic defect analysis of soft tissue profile of postoperative mandibular… Continue reading Chinese Journal of Stomatological Research(Electronic Version), Year 2015, Issue 06 -New Issue Alert.
Chinese Pharmaceutical Affairs, Year 2016, Issue 01 -New Issue Alert.
From: order@email.oriprobe.com Date: February 28, 2016 at 08:01AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Pharmaceutical Affairs. Year 2016 Issue 01 is now available on CAOD. In this issue: Research Progress of Implementation Modes of Drug Negotiation Outcomes for Health Insurance in… Continue reading Chinese Pharmaceutical Affairs, Year 2016, Issue 01 -New Issue Alert.
Medical Journal of National Defending Forces in Northwest China, Year 2015, Issue 06 -New Issue Alert.
From: order@email.oriprobe.com Date: February 28, 2016 at 08:01AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Medical Journal of National Defending Forces in Northwest China. Year 2015 Issue 06 is now available on CAOD. In this issue: xi bei guo fang yi xue za… Continue reading Medical Journal of National Defending Forces in Northwest China, Year 2015, Issue 06 -New Issue Alert.
Medical Journal of National Defending Forces in Northwest China, Year 2015, Issue 06 -New Issue Alert.
From: order@email.oriprobe.com Date: February 28, 2016 at 08:01AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Medical Journal of National Defending Forces in Northwest China. Year 2015 Issue 06 is now available on CAOD. In this issue: xi bei guo fang yi xue za… Continue reading Medical Journal of National Defending Forces in Northwest China, Year 2015, Issue 06 -New Issue Alert.
En utålmodig kreftforsker
En ung pasient med brystkreft gjorde et uutslettelig inntrykk under studietiden. Siden har Giske Ursin jobbet med forebygging av kreft. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1XSv5Cs via IFTTT
Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia
No abstract available from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1K4d55Q via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LN39J7 via IFTTT
Is drinking lemon water really good for you? – The Middle Ground
Is drinking lemon water really good for you? The Middle Ground It does, however, help prevent the development of complications such as pneumonia or lung infection, and it’s also known to reduce symptoms of sore throat, tonsillitis, or asthma. Dr Samarista-Giron also added that vitamin C is an … “Studies show … from #ORL-AlexandrosSfakianakis via… Continue reading Is drinking lemon water really good for you? – The Middle Ground
Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion
Publication date: June 2016 Source:International Journal of Biological Macromolecules, Volume 87 Author(s): Sumi Bang, Eungjae Lee, Young-Gwang Ko, Won Il Kim, Oh Hyeong Kwon Methods for reducing and preventing postoperative abdominal adhesions have been researched for decades; however, despite these efforts, the formation of postoperative peritoneal adhesions is continuously reported. Adhesions cause serious complications such… Continue reading Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion
Chinese Journal of Applied Physiology, Year 2015, Issue 06 -New Issue Alert.
From: order@email.oriprobe.com Date: February 28, 2016 at 08:01AM New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Applied Physiology. Year 2015 Issue 06 is now available on CAOD. In this issue: General Information for Authors …… page:478 A mini review: Tau transgenic… Continue reading Chinese Journal of Applied Physiology, Year 2015, Issue 06 -New Issue Alert.
Chitin and chitosan from the Norway lobster by-products: Antimicrobial and anti-proliferative activities
Publication date: June 2016 Source:International Journal of Biological Macromolecules, Volume 87 Author(s): Nadhem Sayari, Assaâd Sila, Baha Eddine Abdelmalek, Rihab Ben Abdallah, Semia Ellouz-Chaabouni, Ali Bougatef, Rafik Balti Chitin was recovered through enzymatic deproteinization of the Norway lobster (Nephrops norvegicus) processing by-products. The obtained chitin was characterized and converted into chitosan by N-deacetylation, the acid-soluble… Continue reading Chitin and chitosan from the Norway lobster by-products: Antimicrobial and anti-proliferative activities
Effect of vitamin D3 on chemokine levels and regulatory T-cells in pulmonary tuberculosis
Publication date: May 2016 *Source:*International Immunopharmacology, Volume 34 Author(s): M. Harishankar, S. Anbalagan, P. Selvaraj 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] the active form of vitamin D3 acts as an immunomodulator in various immune cells. The present study is aimed to study the effect of 1,25(OH)2D3 on chemokine levels and regulatory T-cells in 51 healthy controls (HCs) and 50 pulmonary tuberculosis (PTB) patients. Peripheral blood mononuclear cells were cultured with culture filtrate antigen (CFA) of Mycobacteriumtuberculosis in the presence or absence of 1,25(OH)2D3...περισσότερα »
Organic acid component from Taraxacum mongolicum Hand.-Mazz alleviates inflammatory injury in lipopolysaccharide-induced acute tracheobronchitis of ICR mice through TLR4/NF-κB signaling pathway
Publication date: May 2016 *Source:*International Immunopharmacology, Volume 34 Author(s): Nan Yang, Chao Li, Gang Tian, Maomao Zhu, Weiquan Bu, Juan Chen, Xuefeng Hou, Liuqing Di, Xiaobin Jia, Zibo Dong, Liang Feng Inflammation plays an important role in the pathogenesis of acute tracheobronchitis. Taraxacum mongolicum Hand.-Mazz (TMHM) is a dietic herb for heat-clearing and detoxifying functions as well as swell-reducing and mass-resolving effect in Traditional Chinese Medicine. Studies have shown that its major ingredient organic acid component (OAC) possesses favorable anti-infl... περισσότερα »
Management of Avian pox in Turkeys
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
2016-02-27T23-59-58Z *Source:* International Journal of Livestock Research Chaitanya yalavarthi, deepthi balam, Ramesh putchakayala. Turkey poults were presented to clinic with cutaneous pustules all over body. Based on findings of clinical examination and lesions it was diagnosed as Avian pox. Successful management of Avian pox with procain pencillin and clinical outcome were discussed. from Scope via xlomafota13 on Inoreader http://ift.tt/1QPw8DP via IFTTT
Reproductive and Early Growth Traits of Intensively Reared West African Dwarf (WAD) Kids in a Humid Tropical Environment
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
2016-02-27T23-59-58Z *Source:* International Journal of Livestock Research Paul Chidiebere Okafor, Cosmas Chikezie Ogbu, Hariet Ndofor-Foleng. The objectives of the study were to evaluate the reproductive, early growth and linear body traits of WAD goats reared intensively. Twenty-five WAD goats (20 does and 5 bucks) aged 7-8 months (9.0 to 12.0kg bwt) were mated naturally (1 buck: 4 does) to generate the kids studied. Animals were managed intensively. Kids suckled their dams until weaning before being separated. Litter size at birth, sex of kid, body weight (BW) and linear body tra... περισσότερα »
Development of a scale for the evaluation of patients’ rights prerequisites at educational hospitals in Iran: a study using the Delphi technique
The patients' rights status is one of the essential elements in defining norms related to the concept of clinical governance system. In addition, the patients' rights status is an important index for quality of care offered in the health care system. However, the lack of a coherent instrument makes it difficult to evaluate patients' rights status in hospitals and clinics. The aim of this study was to develop an instrument for the evaluation of patients' rights prerequisites at educational hospitals in Iran. This study was conducted using the modified Delphi technique. In this stu... περισσότερα »
Patients’ lived experiences regarding maintaining dignity
Preservation of dignity is frequently emphasized as a basic patient's right in national and international nursing codes of ethics and is indeed the essence and core of nursing care. It is therefore essential to explore the concept based on patients' lived experiences in order to maintain and respect their dignity and consequently improve the quality of health services and patient satisfaction. The present study aimed to discover the lived experiences of Iranian patients regarding maintaining their dignity at the bedside. This qualitative study was conducted using an interpretive ... περισσότερα »
A complementary response to the article “breaching confidentiality: medical mandatory reporting laws in Iran”
The article is Commentary and has no abstract from #ENT via xlomafota13 on Inoreader http://ift.tt/1VLjmUQ via IFTTT
Patients’ lived experiences regarding maintaining dignity
Preservation of dignity is frequently emphasized as a basic patient's right in national and international nursing codes of ethics and is indeed the essence and core of nursing care. It is therefore essential to explore the concept based on patients' lived experiences in order to maintain and respect their dignity and consequently improve the quality of health services and patient satisfaction. The present study aimed to discover the lived experiences of Iranian patients regarding maintaining their dignity at the bedside. This qualitative study was conducted using an interpretive ... περισσότερα »
A complementary response to the article “breaching confidentiality: medical mandatory reporting laws in Iran”
The article is Commentary and has no abstract from #ORL via xlomafota13 on Inoreader http://ift.tt/1VLjmUQ via IFTTT
Target maneuver discrimination using ISAR image in interception
Discrimination for target maneuver magnitude and direction switching during the endgame is significant for interception performance improvement. Inverse synthetic aperture radar (ISAR) images carry the informa... from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1SQT6KG via IFTTT
Frequency domain soft-constraint multimodulus blind equalization for uplink SC-FDMA
Single-carrier frequency division multiple access (SC-FDMA) has been adopted and employed as the standard in the 3rd Generation Partnership Project (3GPP) Long-Term Evolution (LTE) uplink multiple-access schem... from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1T3X2IB via IFTTT
Patient privacy and security concerns on big data for personalized medicine
Abstract Established and emerging organizational, methodological and technological paradigm changes health systems around the world are faced with, dramatically impact the administrative, legal and social framework as well as processes of, but also roles and responsibilities of actors involved in, health services delivery. Security, privacy and trust are major concerns in that context to be appropriately managed. After shortly illustrating the aforementioned paradigm changes, the resulting changes regarding roles and ways of acting of the different principals involved in health car... περισσότερα »
Design implications of e-Health systems for a sustainable growth
Abstract The advent of the e-Health paradigm involves radical changes in the methodologies for the design of application of information and communication technologies to health systems. This paradigm places the citizen in the center of the healthcare, what represents new challenges regarding both the healthcare process, which is moved from a centralized hospital-based model to a distributed and ubiquitous care, and the way technologies need to be applied to make this shift possible. In particular, special attention must be paid to interoperability in order to yield sustainable sys... περισσότερα »
Empowering consumers with improved immunization intelligence through technology and social frameworks
Abstract Consumer engagement has emerged as a key factor contributing to improved health outcomes. Leveraging health information technology and social frameworks to provide consumers accurate and timely feedback offers the promise of better health. This chapter illustrates through historical evidence that individuals empowered with information are highly motivated, leading them to take actions that stem the spread of and eradicate preventable disease. It presents through applied practice a technical framework that links the health care community with consumers and through stories ...περισσότερα »
The Occurrence of Postconflict Skills in Captive Immature Chimpanzees ( Pan troglodytes )
Abstract Conflict management strategies can reduce costs of aggressive competition in group-living animals. Postconflict behaviors such as reconciliation and third-party postconflict affiliation are widely accepted as social skills in primates and have been demonstrated in many species. Although immature primates possess a repertoire of species-specific behaviors, it is thought that they gradually develop appropriate social skills throughout prolonged juvenility to establish and maintain complex social relationships within their group. We examined the occurrence of postconflict ski... περισσότερα »
Hand Preference for a Novel Bimanual Coordinated Task During Termite Feeding in Wild Western Gorillas ( Gorilla gorilla gorilla )
Abstract Although the level of handedness in humans varies cross-culturally, humans are generally described as right-handed, which has been considered a uniquely human trait. Recently, captive chimpanzees (*Pan troglodytes*) have been shown to exhibit right-hand preference when performing bimanual but not unimanual tasks. Less clear is whether this pattern also occurs in wild chimpanzees and other African apes. Using videos (*N* = 49) of six wild western gorillas (*Gorilla gorilla gorilla*) feeding on termites at the Mondika Research Center (Republic of Congo), we tested whether th... περισσότερα »
Journal of Real-Time Image Processing: third issue of volume 11
from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1L6BOqq via IFTTT
Real-time patch-based medical image modality propagation by GPU computing
Abstract The synthesis of patient data of a certain medical image modality by applying an image processing pipeline starting from other modality is receiving a lot of interest recently, as it allows to save acquisition time and sometimes avoid radiation to the patient. An example of this is the creation of computerized tomography volumes from magnetic resonance imaging data, which can be useful for several applications such as electromagnetic simulations, cranial morphometry and attenuation correction in PET/MR systems. We present a fast patch-based algorithm for this purpose, imp... περισσότερα »
Special issue on architectures of smart cameras for real-time applications
from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1OczDMF via IFTTT
Internationale Forschung und nationale Weiterbildung
from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1LEuSM6 via IFTTT
Generalized interpolation material point method for coupled thermo-mechanical processes
Abstract In this paper, a generalized interpolation material point method (GIMP) for simulating coupled thermo-mechanical processes is developed based on the weak formulations of both conservation of momentum and conservation of energy. The coupling term between the thermal and mechanical field variables is investigated in detail. The convergence behavior of the GIMP is examined with respect to the number of background cells and the number of particles per cell, respectively. A multi-grid approach is proposed to improve the accuracy of the GIMP in dealing with the Dirichlet boundar... περισσότερα »
Polymorphous low-grade adenocarcinoma: A Danish national study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Publication date: April 2016 Source:Oral Oncology, Volume 55 Author(s): Mohammad Talal Elhakim, Helle Breinholt, Christian Godballe, Lisbeth Juhler Andersen, Hanne Primdahl, Claus A. Kristensen, Kristine Bjørndal ObjectivesTo present a national series of polymorphous low-grade adenocarcinoma (PLGA) patients, including survival rates and an analysis of prognostic factors.Materials and methodsBy merging three Danish nationwide registries, 73 patients […]
