Pain after surgery: Neuromas
Pain after breast surgery: Etiology, diagnosis, and definitive management: Background Breast procedures are among the most common surgeries performed by Plastic Surgeons. The prevalence of persistent pain remains unknown. Our experience has been that persistent breast pain is often related to intercostal nerve trauma. The purpose of this article was to increase awareness of this problem while describing the diagnostic and management strategies for patients with post-operative breast pain. Methods A retrospective review of 10 patients with breast pain was stratified according to the ...περισσότερα »
Segmental mandible reconstruction with fibula in the polyurethane model
Biomechanical assessment of fixation methods for Background A variety of plating techniques are employed by microsurgeons to provide rigid fixation for vascularized bone constructs of the mandible. The aim of this study was to biomechanically compare three commonly utilized plating techniques for rigid fixation of fibula bone flaps in reconstructing lateral segmental mandibular defects. Materials and Methods Polyurethane mandibles with 3-cm segmental defects were reconstructed using polyurethane fibula models. Three fixation techniques were compared (*n* = 5 models per group): Gro...περισσότερα »
Methadone treatment, bruxism, and temporomandibular disorders
among male prisoners: There is little information on bruxism related to illicit drug use. Prolonged drug use may damage the stomatognathic system via oral motor overactivity. The aim of the present study was to compare the rates of bruxism and temporomandibular disorders (TMDs) between prisoners with and without drug-use disorders, to evaluate the association between methadone treatment and bruxism and to assess the possible relationship between bruxism and pain. The sample included 152 male prisoners, 69 of whom were drug users maintained on methadone. All prisoners were examined...περισσότερα »
Therapeutic Effects of Sildenafil on Experimental Mandibular Fractures.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Objectives: No previous studies have examined the effect of sildenafil on fracture healing. This study was designed to investigate the effect of sildenafil on the fracture healing process. Methods: Thirty-six female Sprague-Dawley rats (3-month-old) were used in this study. Animals were randomly divided into 2 groups based on treatment duration (1 week versus 4 weeks) […]
Pediatric National Surgical Quality Improvement Program: Useful for Quality Improvement in Craniosynostosis Surgery?.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
The American College of Surgeons and the American Pediatric Surgical Association collaborate to provide pediatric hospitals with multispeciality surgical outcomes data through the Pediatric National Surgical Quality Improvement Program (NSQIP Peds). The authors used this national multicenter database to describe 30-day outcomes from craniosynostosis surgery and identify associations with perioperative events and blood transfusion. Data […]
Maxillary Sinus Floor Elevation Using Platelet-Rich Plasma Combined With Either Biphasic Calcium Phosphate or Deproteinized Bovine Bone.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Purpose: Maxillary sinus floor elevation procedure has the objective of augmenting available bone in atrophic posterior maxilla to allow dental implants placement. The main aim of this prospective study was to evaluate clinically and histomorphometrically the performance of biphasic calcium phosphate (BCP) used in conjunction with platelet-rich plasma (PRP) compared with demineralized bovine bone matrix […]
Adjunctive Effect of Autologus Platelet-Rich Fibrin to Barrier Membrane in the Treatment of Periodontal Intrabony Defects.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Background and Aim: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic […]
Pincer Flap for Reconstruction of Nasal Tip Defects.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Introduction: Reconstruction of the nasal tip defects is challenging because of variable contours of the region and the unique texture, thickness, color, and limited amount of available skin. There are several well-known local flaps for this purpose. Unfortunately, most of these flaps are suitable for small sized defects up to 2 cm in diameter. In […]
In the Heart of the Sea: How to Get a Motif?.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
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Adolescents and Young Adult Cancer Trial Participation: Will the National Community Oncology Research Program Also Fail? And What About the Rest of Us? Editorial
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
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New Diagnosis Bundle: Improving Care Delivery for Patients With Newly Diagnosed Cancer Editorial
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
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ReCAP: Use of Survivorship Care Plans and Analysis of Patient-Reported Outcomes in Multinational Patients With Lung Cancer Care Delivery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
QUESTION ASKED: What are the most common late or long-term effects (LLTEs) needing to be addressed in lung cancer survivors, and is it feasible to generate survivorship care plans (SCPs) using patient-reported outcomes (PROs) and an Internet-based program? SUMMARY ANSWER: For lung cancer patients worldwide, it is feasible to obtain PROs and create SCPs through […]
ReCAP: Easier Said Than Done: Keys to Successful Implementation of the Distress Assessment and Response Tool (DART) Program Care Delivery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
QUESTION ASKED: What are the key strategies for successful implementation of distress screening based on the experience of the Distress Assessment and Response Tool (DART) program? SUMMARY ANSWER: Key strategies are to use a multi-symptom tool rather than only screening for emotional distress, adopt a clinic-based first assessment response rather than automatic psychosocial referral, and […]
Soft tissue augmentation procedures at second-stage surgery
: a systematic review: Abstract ObjectivesThe aim of this systematic review was to evaluate the efficacy of different soft tissue augmentation/correction methods in terms of increasing the peri-implant width of keratinized mucosa (KM) and/or gain of soft tissue volume during second-stage surgery. Materials and methodsScreening of two databases, MEDLINE (PubMed) and EMBASE (OVID), and hand search of related articles, were performed. Human studies reporting on soft tissue augmentation/correction methods around submucosally osseointegrated implants during second-stage surgery up t...περισσότερα »
Factors influencing intraoperative blood loss
in orthognathic surgery via Oral and Maxillofacial Surgery Publication date: Available online 4 April 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): M. Thastum, K. Andersen, K. Rude, S.E. Nørholt, J. Blomlöf This retrospective study aimed to identify factors of importance for intraoperative blood loss relative to total blood volume in patients undergoing orthognathic surgery. The study included 356 patients treated consecutively at a Danish university hospital between 1 January 2010 and 31 December 2012. Inclusion criteria were (1) patient age ≥18 year...περισσότερα »
Low-intensity pulsed ultrasound accelerates nerve regeneration
following inferior alveolar nerve transection in rats: Inferior alveolar nerve (IAN) injury, which is frequently caused by orofacial surgery or trauma, induces sensory loss in orofacial regions innervated by the IAN. However, no effective treatment for orofacial sensory loss currently exists. We determined whether sensory loss in facial skin above the mental foramen following IAN transection was recovered by exposure of the transected IAN to low-intensity pulsed ultrasound (LIPUS). Inferior alveolar nerve transection (IANX) was performed in 7-wk-old male Sprague-Dawley rats. On da... περισσότερα »
Occult nodal disease : Watchful waiting of the neck in early stage oral cancer
is unfavourable for patients with occult nodal disease via Oral and Maxillofacial Surgery Publication date: Available online 4 April 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): E.A. Dik, S.M. Willems, N.A. Ipenburg, A.J.W.P. Rosenberg, E.M. Van Cann, R.J.J. van Es For cT1/2N0 oral squamous cell carcinoma (OSCC), treatment of the neck is a matter of debate. Two treatment strategies were evaluated in this study: selective neck dissection (SND) and watchful waiting (WW). One hundred and twenty-three SND patients and 70 WW patients with cT1/T2N0M0 OSCC ...περισσότερα »
Influence of wound closure on the volume stability of particulate and non-particulate GBR materials: an in vitro cone-beam computed tomographic examination. Part II
[image: cover.gif?v=1&s=ea3ed681cef4af2a1760b136] Abstract Objectives To test whether GBR with an L-shaped soft-block bone substitute and particulate bone substitute differs from GBR with particulate bone substitute as regards the volume stability of the augmented region during flap closure. Materials and methods Twenty peri-implant box-shaped bone defects were created in 10 pig mandibles. Every bone defect was augmented with each of the following two GBR procedures in turn: control group – particulate xenograft applied buccally + collagen membrane + pins; test group – particul...περισσότερα »
Gingival overgrowth induced by cyclosporine-A: Azithromycin and metronidazole combined therapy
Efficacy of azithromycin and metronidazole combined therapy on rats’ gingival overgrowth induced by cyclosporine-A: An experimental animal study via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 5 April 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Mohammed Ali Elkabir, Rehab R. El-Zehery, Mohamed I. Mourad, Omar Soliman, Mohamed E. Helal, Ali K. Refai, Mohammed E. Grawish AimsTo evaluate the therapeutic efficacy of azithromycin (azm) and/or metronidazole (mtz) on the histopathological feature... περισσότερα »
Use of the Integra skin regeneration system in an intraoral mandibular defect in osteoradionecrosis
Use of the Integra skin regeneration system in an intraoral mandibular defect in osteoradionecrosis: The objective was to trial the use of the Integra skin regeneration system intraorally to promote healing of an intraoral defect in osteoradionecrosis (ORN), thereby avoiding the necessity for mucosal flaps, free flaps, or skin grafts. A 54-year-old male patient presented with a pathological mandibular fracture at the angle, related to previous radiotherapy for tonsillar carcinoma, after the development of ORN. The fracture site was debrided and fixed with a reconstruction plate and ... περισσότερα »
Weight Loss Associated with Platinum-Based Chemotherapy
in Patients with Advanced Lung Cancer: *Background:* We examined whether the weight loss that occurs with platinum-based chemotherapy in lung cancer patients is associated with chemotherapy side effects, treatment completion rates and therapeutic effect. *Methods:* We retrospectively reviewed charts of advanced lung cancer patients treated with ≥2 cycles of platinum-based chemotherapy. Patients were divided into 2 groups based on ≥5 or *Results:* Among 114 patients, 18 (15.8%) experienced ≥5% weight loss. Significantly more patients with small-cell lung cancer (SCLC) than with non-S...περισσότερα »
Paclitaxel in Patients with Docetaxel-Resistant Esophageal Squamous Cell Carcinoma
Efficacy and Safety Assessment of Paclitaxel in Patients with Docetaxel-Resistant Esophageal Squamous Cell Carcinoma: *Background:* Incomplete cross-resistances between paclitaxel (PTX) and docetaxel (DTX) has been demonstrated in several types of cancer. The objective of the present study was to assess the existence of cross-resistance between PTX and DTX in esophageal squamous cell carcinoma. *Methods:* Patients in the PTX group received PTX without DTX pretreatment, patients in the prior DTX (Pr-DTX) group received PTX after the development of resistance to DTX, and patients in t... περισσότερα »
Circulating miR-122 and prognosis of chronic HBV-related liver failure
Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure: Abstract Aim To determine a correlation between circulating microRNA (miR-122) and prognosis of chronic HBV-related liver failure (CHBLF). Methods Circulating miRNA from CHBLF patients (n = 6) and healthy control (HC) (n = 6) were quantified, using Exiqon LNA microarray.qRT-PCR was utilized to confirm highly modified circulating miRNA-122 from a large group of subjects: CHBLF (n = 58), HC (n = 23), acute hepatitis B (AHB) (n = 10), chronic hepatitis B (CHB) (n = 22) and hepatitis B cirrhosis ...περισσότερα »
Hearing Loss in Patients with Inflammatory Bowel Disease
Hearing Loss in Patients with Inflammatory Bowel Disease: Abstract Background and AimsInflammatory bowel disease (IBD) has many characteristics of autoimmune diseases. Sensorineural hearing loss has been reported in many autoimmune diseases. Little is known about hearing loss in patients with IBD. MethodsA prospective blinded comparative study was conducted over a 3-year period. IBD patients and controls underwent a complete otorhinolaryngeal examination and eudiometry test. ResultsAltogether 105 participants (76 patients and 29 controls) took part in this study. Mean age w...περισσότερα »
CagA+ or VacA+ H. pylori in the stomach of patients may suppress DUOX2 expression to promote its own survival. Increased NOX2 could not eliminate H. pylori infection.
The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA−/VacA− H. pylori: Abstract Background*Helicobacter pylori* (*H. pylori)* is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), a member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis and host mucosal defense. AimTo investigate the effect of *H. pylori* infection on DUOX2 gene expression in human stomach. Mater...περισσότερα »
Periodontal diseases as a source of halitosis.The innate and adaptive immune responses in periodontal diseases.
*Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists: * Abstract *Bad breath (halitosis) is an important social complaint. In most cases (≥90%), the cause of halitosis can be found within the oral cavity. Under this circumstance, the term oral malodor applies. It affects both healthy and periodontally diseased individuals. Oral malodor is mainly caused by a microbial degradation of both sulfur-containing and nonsulfur-containing amino acids into volatile, bad-smelling gases. Anaerobic gram-negative bacte... περισσότερα »
The mineral-stabilizing properties of saliva : Dentine remineralization with a potential salivary phosphoprotein homologue
In vitro via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Maria Jacinta Rosario H. Romero, Syozi Nakashima, Toru Nikaido, Alireza Sadr, Junji Tagami ObjectiveAdvantages of introducing a salivary phosphoprotein homologue under standardized in vitro conditions to simulate the mineral-stabilizing properties of saliva have been proposed. This study longitudinally investigates the effects of casein, incorporated as a potential salivary phosphoprotein homologue in artificial saliva (AS) solutions with/without fluoride (F) on in vitro de... περισσότερα »
Osteoclastogenesis
Extract of acai-berry inhibits osteoclast differentiation and activity via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): C. Brito, A.T. Stavroullakis, A.C. Ferreira, K. Li, T. Oliveira, G.J. Crasto, G. Nogueira-Filho, A. Prakki Osteoclastogenesis is the major cellular event responsible for bone loss and is triggered by inflammation. Acai-berry has proven anti-inflammatory effects. However, there is a lack of evidence for its effects on osteoclastogenesis. Thus, the aim of this study was to determine whether acai-berry extract (ABE) c... περισσότερα »
Stevens-Johnson syndrome and toxic epidermal necrolysis
[Stevens-Johnson syndrome and toxic epidermal necrolysis].: Authors: Kaur-Knudsen D, Zachariae C, Thomsen SF Abstract Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most common drugs involved are antibiotics, antiepileptic medicine, allopurinol and nonsteroidal anti-inflammatory drugs. Besides withdrawing the suspected drug the treatment is ...περισσότερα »
Pediatric Dermatology
Atypical Fibroxanthoma in a 13-Year-Old Guatemalan Girl with Xeroderma Pigmentosum Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13-year-old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's...περισσότερα »
Toxic epidermal necrolysis triggered by clobazam
: a case report in a 13-year-old girl.: [image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Dang CD, Beets-Shay L, Kahn EC Abstract We present a case of toxic epidermal necrolysis (TEN) triggered by clobazam in a 13-year-old girl who was subsequently treated with intravenous immunoglobulin. In December 2013 the U.S. Food and Drug Administration released a warning that clobazam might cause "serious skin reactions" such as Stevens-Johnson syndrome or TEN and approved label changes. PMID: 25690725 [PubMed - indexed for MEDLINE]
Efficacy of nystatin for the treatment of oral candidiasis
: a systematic review and meta-analysis.: Authors: Lyu X, Zhao C, Yan ZM, Hua H Abstract OBJECTIVE: To systematically review and assess the efficacy, different treatment protocols (formulation, dosage, and duration), and safety of nystatin for treating oral candidiasis. METHODS: Four electronic databases were searched for trials published in English till July 1, 2015. Randomized controlled trials comparing nystatin with other antifungal therapies or a placebo were included. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis or descriptive study on the eff... περισσότερα »
Managing children with sialorrhoea (drooling)
: Experience from the first 301 children in our saliva control clinic via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Jenny Montgomery, Sarah McCusker, Kerry Lang, Susan Grosse, Alastair Mace, Ruby Lumley, Haytham Kubba ObjectivesSialorrhoea (drooling) is defined as the involuntary escape of saliva from the mouth. It is considered normal in young children but may cause social problems in older children. Sialorrhoea is frequently seen in children with cerebral pals... περισσότερα »
Pathophysiology of Olfactory Disorders
and Potential Treatment Strategies: AbstractOlfactory disorders have been regarded in the past with a sense of therapeutic nihilism. However, there have been remarkable advances in chemosensory research over the past several years. The clinical importance of olfactory disorders is well established, and entities such as presbyosmia have gained considerable broad attention. Powerful basic science experimental approaches have revealed aspects of olfactory neuron physiology, olfactory tissue maintenance, and regeneration that provide new potential therapeutic targets for certain forms... περισσότερα »
The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA−/VacA− H. pylori
Abstract Background *Helicobacter pylori* (*H. pylori)* is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), a member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis and host mucosal defense. Aim To investigate the effect of *H. pylori* infection on DUOX2 gene expression in human stomach. Materials and Methods The biopsies were obtained from patients who underwent endoscopic diagnosis. The patient serum was assayed for two virulence factors of *H. pylori,* CagA IgG and VacA. The... περισσότερα »
Albumin May Prevent the Morbidity of Paracentesis-Induced Circulatory Dysfunction in Cirrhosis and Refractory Ascites: A Pilot Study
Abstract Background Large-volume total paracentesis may result in paracentesis-induced circulatory dysfunction, which is associated with poor outcomes. Aims To explore the short- and long-term effects of paracentesis-induced circulatory dysfunction on systemic hemodynamics, renal function and other cirrhosis-related complications in patients with refractory ascites, following subtotal large-volume paracentesis. Methods Patients with cirrhosis and refractory ascites without renal dysfunction had systemic hemodynamics, renal function, and neurohormones (plasma active renin, aldost... περισσότερα »
Treatment of Dual Genotype Chronic Hepatitis C: Case Series
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Endotracheal tubes and the cricoid
: Is there a good fit? via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Mahmood Rafiq, Tariq M. Wani, Melissa Moore-Clingenpeel, Joseph D. Tobias BackgroundChoosing an appropriately sized endotracheal tube (ETT) is important in pediatric patients as an inappropriately sized ETT may result in multiple endotracheal intubation attempts or excessive pressure on the tracheal mucosa with the potential for airway damage. Although age-based formulas are generally used wit... περισσότερα »
Opioid Therapy and Abuse
Current State of AbstractCurrently, there is growing tension between the twin challenges of opioid therapy for chronic pain and adverse consequences of abuse, leading to multiple complications including respiratory failure and death. The recent data from Centers for Disease Control and Prevention (CDC) have shown continued escalation of prescription opioid use with opioid overdose deaths topping all previous estimations. Numerous policy initiatives, advisories, and guidelines have been advanced through the years to control the opioid epidemic. The strategies to prevent opioid abuse... περισσότερα »
Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Related Articles *Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment.* Head Neck. 2016 Apr 4; Authors: Sigston EA, Longano A, Strzelecki AT, Williams BR Abstract BACKGROUND: Margins in head and neck squamous cell carcinoma (HNSCC) are determined by morphological changes assessed via hematoxylin-eosin staining. Physiological changes may not be detected by this technique. The purpose of this study was to determine if a protein biomarker, laminin-332γ2, overexpressed in cancer cells at the invasi... περισσότερα »
HPV Positive Head and Neck Cancers: Molecular Pathogenesis and Evolving Treatment Strategies.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Related Articles *HPV Positive Head and Neck Cancers: Molecular Pathogenesis and Evolving Treatment Strategies.* Cancers (Basel). 2016;8(4) Authors: Dok R, Nuyts S Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that is the result of tobacco and/or alcohol abuse or infection with high-risk Human papillomaviruses. Despite the fact that HPV positive HNSCC cancers form a distinct clinical entity with better treatment outcome, all HNSCC are currently treated uniformly with the same treatment modality. At present, biologic basis of these diffe... περισσότερα »
Hashimoto's Thyroiditis and Graves' Disease in One Patient: The Extremes of Thyroid Dysfunction Associated with Interferon Treatment.
Related Articles *Hashimoto's Thyroiditis and Graves' Disease in One Patient: The Extremes of Thyroid Dysfunction Associated with Interferon Treatment.* Case Rep Endocrinol. 2016;2016:6029415 Authors: Bishay RH, Chen RC Abstract Autoimmune thyroid disease associated with interferon therapy can manifest as destructive thyroiditis, Graves' Hyperthyroidism, and autoimmune (often subclinical) hypothyroidism, the latter persisting in many patients. There are scare reports of a single patient developing extremes of autoimmune thyroid disease activated by the immunomodulatory effects of... περισσότερα »
Triiodothyroacetic acid treatment in MCT8 deficiency: a word of nuance.
Related Articles *Triiodothyroacetic acid treatment in MCT8 deficiency: a word of nuance.* Thyroid. 2016 Apr 4; Authors: Visser WE, Heuer H, Visser TJ PMID: 27042766 [PubMed - as supplied by publisher] from thyroid via a.lsfakia on Inoreader http://ift.tt/1Xfr767 via IFTTT
Occupational-related hazards (OH) amongst Otolaryngologists
An overview of occupational hazards amongst UK Otolaryngologists: AbstractOccupational-related hazards (OH) are noted to be prevalent within the medical community. However, there is limited evidence of its effects amongst ENT surgeons. A national survey was carried out with the assistance of ENT-UK to investigate the prevalence of various OH amongst ENT doctors in the UK. A literature search was also conducted to search for articles within English literature worldwide on this subject. 70.6 % of the responding 323 ENT surgeons had reported a form of OH throughout their career. Muscu...περισσότερα »
Eardrum thickening approach for the treatment of patulous Eustachian tube
Eardrum thickening approach for the treatment of patulous Eustachian tube: AbstractThis study aims to explore the eardrum thickening approach via cartilage myringoplasty for the cessation of symptoms of patulous Eustachian tube (PET), including autophony, aural fullness and breathing synchronous tinnitus. A total of 12 patients who met the diagnosis criteria of PET were included and given an eardrum patching test preoperatively. Then, myringoplasty with ipsilateral full-thickness tragus cartilage under general anesthesia was performed. All patients were followed up for at least 6 m... περισσότερα »
Hemoptysis : Lung tumor,Bronchitis,Tuberculosis,Mycosis,Trauma.Aorto-oesophageal and aorto-bronchial fistulae,Aortic Extra-anatomic Bypass Pseudoaneurysm,
*Hemoptysis after thoracic endovascular aortic repair* *[Traumatic pseudoaneurysm of descendent thoracic aorta solved by aortal stentgraft repair followed by development of fatal aortoesophageal fistula].Related Articles[Traumatic pseudoaneurysm of descendent thoracic aorta solved by aortal stentgraft repair followed by development of fatal aortoesophageal fistula].Soud Lek. 2015;60(4):46-50Authors: Farkaš D, Špak Ľ, Švajdler Ml M, Iannaccone SF, Sihotský V, Kaťuchová J, Ginelliová AAbstractTraumatic pseudoaneurysms are relatively frequently mentioned in textbooks of patholog... περισσότερα »
A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention
[image: Thumbnail image of graphical abstract] *A novel Janus device with omniphobic and mucoadhesive sides* that exhibit the unique capacity for antifouling and extended gastrointestinal retention is fabricated. This system enables repulsion of the food and fluid stream by the luminal-facing omniphobic side and allows attachment to the gastrointestinal mucosa by the mucoadhesive side. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1McDakj via IFTTT
Fluorescence Detection of H5N1 Virus Gene Sequences Based on Optical Tweezers with Two-Photon Excitation Using a Single Near Infrared Nanosecond Pulse Laser
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00065 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1Wb1RQa via IFTTT
Combined Electron Paramagnetic Resonance and Atomic Absorption Spectroscopy/Inductively Coupled Plasma Analysis As Diagnostics for Soluble Manganese Species from Mn-Based Positive Electrode Materials in Li-ion Cells
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00204 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PSLP5W via IFTTT
Correction to Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry
Analytical Chemistry DOI: 10.1021/acs.analchem.6b01215 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1XfKQTq via IFTTT
Microchannel Voltammetry in the Presence of Large External Voltages and Electric Fields
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00399 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1PSAva3 via IFTTT
Erratum to: Development and application of lateral flow test strip technology for detection of infectious agents and chemical contaminants: a review
from BioChemistry via xlomafota13 on Inoreader http://ift.tt/239ykvz via IFTTT
Reply to Comment Submitted by Murnick et al. on “Intracavity OptoGalvanic Spectroscopy Not Suitable for Ambient Level Radiocarbon Detection”
Analytical Chemistry DOI: 10.1021/acs.analchem.6b00473 [image: ancham?d=yIl2AUoC8zA] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SNNCho via IFTTT
Ply-overlap hybrid technique for joining dissimilar composite materials
Publication date: 15 June 2016 *Source:*Materials & Design, Volume 100 Author(s): Jasim Ahamed, Mathew Joosten, Paul Callus, Michael R. Wisnom, Chun H. Wang Hybridisation of multiple materials is emerging as a key strategy to achieve high performance lightweight structures while keeping the cost low. Fundamental to creating strong and cost-effective hybrid composites is the ability to efficiently join dissimilar materials. Herein we present a novel co-curing ply-overlap joint technique for integrating dissimilar composite materials. Experimental studies are conducted to identify the...περισσότερα »
A matrix-free approach to efficient affine-linear image registration on CPU and GPU
Abstract This paper presents a generic approach to highly efficient image registration in two and three dimensions. Both monomodal and multimodal registration problems are considered. We focus on the important class of affine-linear transformations in a derivative-based optimization framework. Our main contribution is an explicit formulation of the objective function gradient and Hessian approximation that allows for very efficient, parallel derivative calculation with virtually no memory requirements. The flexible parallelism of our concept allows for direct implementation on vari... περισσότερα »
IPAS: a design framework for analysis, synthesis and optimization of image processing applications for heterogenous computing architectures
Abstract Recent trends in the image processing field have led to the use of more heterogeneous hardware architectures. The reason for this increase is that specialized cores, compared to standard CPUs, offer a more efficient way of achieving image processing applications. Specialized cores have less power, resource, and area consumption. On the other hand, designing such a heterogenous system with specialized cores is a challenging, error-prone and time-consuming task. Therefore, new frameworks are necessary for bringing an image processing application onto a given target platform ... περισσότερα »
Operating Room Delays: Meaningful Use in Electronic Health Record.
Perioperative areas are the most costly to operate and account for more than 40% of expenses. The high costs prompted one organization to analyze surgical delays through a retrospective review of their new electronic health record. Electronic health records have made it easier to access and aggregate clinical data; 2123 operating room cases were analyzed. Implementing a new electronic health record system is complex; inaccurate data and poor implementation can introduce new problems. Validating the electronic health record development processes determines the ease of use and the use...περισσότερα »
Effects of Blended Cardiopulmonary Resuscitation and Defibrillation E-learning on Nursing Students' Self-efficacy, Problem Solving, and Psychomotor Skills.
This study was conducted to identify the educational effects of a blended e-learning program for graduating nursing students on self-efficacy, problem solving, and psychomotor skills for core basic nursing skills. A one-group pretest/posttest quasi-experimental design was used with 79 nursing students in Korea. The subjects took a conventional 2-week lecture-based practical course, together with spending an average of 60 minutes at least twice a week during 2 weeks on the self-guided e-learning content for basic cardiopulmonary resuscitation and defibrillation using Mosby's Nursing ... περισσότερα »
Systolic Time Intervals and New Measurement Methods
Abstract Systolic time intervals have been used to detect and quantify the directional changes of left ventricular function. New methods of recording these cardiac timings, which are less cumbersome, have been recently developed and this has created a renewed interest and novel applications for these cardiac timings. This manuscript reviews these new methods and addresses the potential for the application of these cardiac timings for the diagnosis and prognosis of different cardiac diseases. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1qpCOgn via IFTTT
Compressive multi-spectral imaging using self-correlations of images based on hierarchical joint sparsity models
Abstract We propose a novel multi-spectral imaging method based on compressive sensing (CS). In CS theory, the enhancement of signal sparsity is important for accurate signal reconstruction. The main novelty of the proposed method is the employment of a self-correlation of an image, that is a local intensity similarity and multi-spectral correlation, to enhance the sparsity of the multi-spectral image to be recovered. Local intensity similarity, which is based on the concept that spatial changes in intensity are likely to be similar within local regions, contributes to sparsity en... περισσότερα »
Protein-Assisted Assembly of Modular 3D Plasmonic Raspberry-like Core/Satellite Nanoclusters: Correlation of Structure and Optical Properties
[image: TOC Graphic] ACS Nano DOI: 10.1021/acsnano.5b07533 [image: ancac3?d=yIl2AUoC8zA] from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1Sz1k5d via IFTTT
Multilength Scale Patterning of Functional Layers by Roll-to-Roll Ultraviolet-Light-Assisted Nanoimprint Lithography
[image: TOC Graphic] ACS Nano DOI: 10.1021/acsnano.5b07411 [image: ancac3?d=yIl2AUoC8zA] from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1MR9bOU via IFTTT
Efficient uncertainty quantification of a fully nonlinear and dispersive water wave model with random inputs
Abstract A major challenge in next-generation industrial applications is to improve numerical analysis by quantifying uncertainties in predictions. In this work we present a formulation of a fully nonlinear and dispersive potential flow water wave model with random inputs for the probabilistic description of the evolution of waves. The model is analyzed using random sampling techniques and nonintrusive methods based on generalized polynomial chaos (PC). These methods allow us to accurately and efficiently estimate the probability distribution of the solution and require only the co... περισσότερα »
Material stiffness parameters as potential predictors of presence of left ventricle myocardial infarction: 3D echo-based computational modeling study
Ventricle material properties are difficult to obtain under in vivo conditions and are not readily available in the current literature. It is also desirable to have an initial determination if a patient had an... from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/239p8HB via IFTTT
Faint gravitational waves could soon be on LIGO’s radar
In a few years, LIGO could detect hints of faint gravitational waves from black holes too far away to be seen directly. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1S0oeYC via IFTTT
Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla
Tissue Engineering Part A , Vol. 0, No. 0. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1Ye08Io via IFTTT
The CCN Executive Committee invites you to a lecture by Dr. George Koob!
The Center for Clinical and Cognitive Neuroscience Executive Committee is pleased to announce the CCN Distinguished Speaker Series. The goal of this speaker series is to invite high profile speakers to the SDSU campus to provide both public lectures and lectures that highlight new discoveries and cutting-edge research in cognitive neuroscience. ------------------------------ Up Next – Dr. George Koob! The CCN Executive Committee invites you to a lecture by Dr. George Koob! [image: george koob] Dr. George Koob *“Neurobiology of addiction: A stress surfeit disorder”* *Dr. George Koo... περισσότερα »
The CCN Executive Committee invites you to a lecture by Dr. George Koob!
The Center for Clinical and Cognitive Neuroscience Executive Committee is pleased to announce the CCN Distinguished Speaker Series. The goal of this speaker series is to invite high profile speakers to the SDSU campus to provide both public lectures and lectures that highlight new discoveries and cutting-edge research in cognitive neuroscience. ------------------------------ Up Next – Dr. George Koob! The CCN Executive Committee invites you to a lecture by Dr. George Koob! [image: george koob] Dr. George Koob *“Neurobiology of addiction: A stress surfeit disorder”* *Dr. George Koo... περισσότερα »
The CCN Executive Committee invites you to a lecture by Dr. George Koob!
The Center for Clinical and Cognitive Neuroscience Executive Committee is pleased to announce the CCN Distinguished Speaker Series. The goal of this speaker series is to invite high profile speakers to the SDSU campus to provide both public lectures and lectures that highlight new discoveries and cutting-edge research in cognitive neuroscience. ------------------------------ Up Next – Dr. George Koob! The CCN Executive Committee invites you to a lecture by Dr. George Koob! [image: george koob] Dr. George Koob *“Neurobiology of addiction: A stress surfeit disorder”* *Dr. George Koo... περισσότερα »
The CCN Executive Committee invites you to a lecture by Dr. George Koob!
The Center for Clinical and Cognitive Neuroscience Executive Committee is pleased to announce the CCN Distinguished Speaker Series. The goal of this speaker series is to invite high profile speakers to the SDSU campus to provide both public lectures and lectures that highlight new discoveries and cutting-edge research in cognitive neuroscience. ------------------------------ Up Next – Dr. George Koob! The CCN Executive Committee invites you to a lecture by Dr. George Koob! [image: george koob] Dr. George Koob *“Neurobiology of addiction: A stress surfeit disorder”* *Dr. George Koo... περισσότερα »
Prevalence and factors influencing anaemia among pregnant women in rural Mysuru, India
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
2016-04-05T10-32-58Z *Source:* International Journal of Community Medicine and Public Health Anup Gopinath, N. C. Ashok, Praveen Kulkarni, Renuka Manjunath. Background: Anaemia in pregnancy is one of the major causes of maternal morbidity and mortality in India and the world. Determining the status and factors influencing anaemia among pregnant women in rural areas is essential to treat as well as prevent the same. The objective was to estimate the prevalence of anaemia among pregnant women of rural areas of Mysuru, India and to determine the factors influencing anaemia among the st... περισσότερα »
A community based case control study on risk factors for treatment interruptions in people with tuberculosis in Kollam district, Kerala, southern India
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
2016-04-05T10-32-58Z *Source:* International Journal of Community Medicine and Public Health Shameer K. M., Manjunath K., Sam D. Marconi, Krishnaveni V., Rakesh P. S., Jasmin H. Prasad. Background: Treatment adherence to anti-TB treatment is a critical determinant of treatment outcomes, prognosis and further emergence of drug resistance. The objective of the study was to identify the risk factors for treatment interruptions among the newly diagnosed patients with tuberculosis registered for treatment under Revised National Tuberculosis Control Program in Kollam District, Kerala, sou... περισσότερα »
Is the Ambu aScope 3 Slim single-use fiberscope equally efficient compared with a conventional bronchoscope for management of the difficult airway?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
Related Articles *Is the Ambu aScope 3 Slim single-use fiberscope equally efficient compared with a conventional bronchoscope for management of the difficult airway?* J Clin Anesth. 2016 May;30:68-73 Authors: Fukada T, Tsuchiya Y, Iwakiri H, Ozaki M Abstract STUDY OBJECTIVE: The study objective was to evaluate whether the single-use fiberoptic bronchoscope (FOB), Ambu aScope 3 Slim, was equally efficient compared with the conventional reusable FOB, Olympus LF-GP, for nasal fiberoptic intubation in a manikin. DESIGN: A randomized crossed-over study. SETTING: The postanesthesia care... περισσότερα »
Study on cutaneous manifestation among type II diabetes mellitus in rural Pondicherry, India
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
2016-04-05T10-32-58Z *Source:* International Journal of Community Medicine and Public Health Kandaswamy, Kanagarajan P., Suganthi K., Lokeshmaran A.. Background: Diabetes has emerged as a major public health care problem in India. According to Diabetes atlas published by the International Diabetes Federation (IDF), there was on 2007 an estimated 40.9 million people with diabetes in India and this number is predicted to rise to almost 69.9 million people by 2025. The skin is affected by both the acute metabolic derangements and the chronic degenerative complications of diabetes. Cuta...περισσότερα »
Solvothermal synthesis of Ag/ZnO and Pt/ZnO nanocomposites and comparison of their photocatalytic behaviors on dyes degradation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Publication date: Available online 5 April 2016 Source:Advanced Powder Technology Author(s): L. Muñoz-Fernandez, A. Sierra-Fernandez, O. Milošević, M.E. Rabanal Noble metal/ZnO nanoparticles were synthesized by a solvothermal method. The influence of reaction time, noble metal presence or kind of noble metal (Ag or Pt) was evaluated. The prepared samples were characterized by X-ray diffraction (XRD), […]
Discovery of Targeted Radiotherapies through Femtomedicine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
There is a compelling need to develop anticancer therapies that target cancer cells and tissues. Arising from innovative femtomedicine studies, a new class of non–platinum-based halogenated molecules (called FMD molecules) that selectively kill cancer cells and protect normal cells in treatments of multiple cancers has been discovered. This article reports the first observation of the […]
Synergistic Activity of Oncolytic Adenovirus and L-carnosine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Oncolytic viruses are able to specifically replicate, infect, and kill only cancer cells. Their combination with chemotherapeutic drugs has shown promising results due to the synergistic action of virus and drugs; the combinatorial therapy is considered a potential clinically relevant approach for cancer. In this study, we optimized a strategy to absorb peptides on the […]
Precision Oncology: Moores Cancer Center Experience
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
By profiling their patients’ tumors, oncologists now have the option to use molecular results to match patients with drug(s) based on specific biomarkers. In this observational study, 347 patients with solid advanced cancers and next-generation sequencing (NGS) results were evaluated. Outcomes for patients who received a «matched» versus «unmatched» therapy following their NGS results were […]
AR Compromises Cytotoxicity of NK Cells against HCC
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Gender disparity has long been considered as a key to fully understand hepatocellular carcinoma (HCC) development. At the same time, immunotherapy related to IL12 still need more investigation before being applied in clinical settings. The aim of this study is to investigate the influence of the androgen receptor (AR) on natural killer (NK) cell–related innate […]
3D Tumor Growth Assays with Low-Passage Patient Tumors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular-targeted agents. Here, we describe a method to directly embed low-passage patient tumor–derived tissue into basement membrane extract, […]
ABT-414: A Tumor-Selective EGFR-Targeting ADC
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Targeting tumor-overexpressed EGFR with an antibody–drug conjugate (ADC) is an attractive therapeutic strategy; however, normal tissue expression represents a significant toxicity risk. The anti-EGFR antibody ABT-806 targets a unique tumor-specific epitope and exhibits minimal reactivity to EGFR in normal tissue, suggesting its suitability for the development of an ADC. We describe the binding properties and […]
CDK Inhibition Sensitizes p53-Mutated Cells to Doxorubicin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone receptor, and HER2. Hence, TNBC patients cannot benefit from clinically available targeted therapies and rely on chemotherapy and surgery for treatment. While initially responding to chemotherapy, TNBC patients are at increased risk of developing distant metastasis and […]
Bevacizumab Prevents Brain Metastases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Patients with nonsquamous non–small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti–VEGF-A therapy may prevent the formation of nsNSCLC brain metastases. Whether non-brain metastases are also prevented, and whether bevacizumab shows a brain metastases–preventive activity in cancer patients is unknown. Data of one […]
An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Hypoxic gene expression contributes to the pathogenesis of many diseases, including organ fibrosis, age-related macular degeneration, and cancer. Hypoxia-inducible factor-1 (HIF1), a transcription factor central to the hypoxic gene expression, mediates multiple processes including neovascularization, cancer metastasis, and cell survival. Pyrrole-imidazole polyamide 1 has been shown to inhibit HIF1-mediated gene expression in cell culture but […]
The CCN Executive Committee invites you to a lecture by Dr. George Koob!
The Center for Clinical and Cognitive Neuroscience Executive Committee is pleased to announce the CCN Distinguished Speaker Series. The goal of this speaker series is to invite high profile speakers to the SDSU campus to provide both public lectures and lectures that highlight new discoveries and cutting-edge research in cognitive neuroscience. ------------------------------ Up Next – Dr. George Koob! The CCN Executive Committee invites you to a lecture by Dr. George Koob! [image: george koob] Dr. George Koob *"Neurobiology of addiction: A stress surfeit disorder"* *Dr. George K... περισσότερα »
Mapping of Vocal Risk in Amateur Choir
Publication date: Available online 4 April 2016 *Source:*Journal of Voice Author(s): Milka Rosa, Mara Behlau ObjectivesThe study aimed to investigate and map the existence of vocal risk in amateur singers, analyzing the contribution of general voice signs and symptoms, specific singing handicap, and generalized anxiety.Study DesignThis is a cross-sectional study.MethodsThe sample comprised 526 volunteer amateur choristers—186 male and 340 female—(mean age of 42.07 years) from different choirs in the region of São Paulo. Three questionnaires were used: the Voice Symptom Scale (VoiSS)... περισσότερα »
Laryngeal Electromyography for Prognosis of Vocal Fold Paralysis
Publication date: Available online 5 April 2016 *Source:*Journal of Voice Author(s): Adriana Pardo-Maza, Isabel García-Lopez, Susana Santiago-Pérez, Javier Gavilán ObjectiveThis study aimed to determine the value of laryngeal electromyography in the prognosis of vocal fold paralysis.Study DesignThis is a retrospective descriptive study.Materials and MethodsThis study included 80 patients diagnosed with unilateral or bilateral vocal fold paralysis on flexible laryngoscopy between 2002 and 2014 in a tertiary medical center. Laryngeal electromyography using a standardized protocol was... περισσότερα »
Characterization of a novel high-dose ovalbumin-induced murine model of allergic sinonasal inflammation
Background Few efficacious topical therapies exist for chronic rhinosinusitis (CRS). The lack of a reproducible mouse model of CRS limits the pilot testing of potential novel anti-inflammatory therapies. Although the ovalbumin-induced mouse model of sinonasal inflammation is commonly used, it is difficult to reproduce and can generate variable histologic results. In this study, we explore a variation of this model in different strains of mice and explore various inflammatory cytokines as reproducible molecular markers of inflammation. Methods Allergic sinonasal inflammation was ... περισσότερα »
Predictive significance of computed tomography in eosinophilic chronic rhinosinusitis with nasal polyps
Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP), characterized by eosinophil-predominant inflammation in mucosa, is a subject of much investigation. However, no satisfactory atraumatic clinical parameter has been established to date for prediagnosis of this condition. The aim of this study was therefore to compare the use of computed tomography (CT) scans with other clinical parameters in prediagnosis of eCRSwNP. Methods This was a prospective cohort, single-institution study. Two hundred consecutive CRSwNP patients (123 eCRSwNP and 77 non-eosinophilic... περισσότερα »
Tumor necrosis factor-α regulates interleukin-33 expression through extracellular signal-regulated kinase, p38, and nuclear factor–κB pathways in airway epithelial cells
Background Interleukin (IL)-33 plays an important role in controlling immune responses in barrier tissues, and is a potent mediator of inflammatory diseases such as asthma, rheumatoid disease, and chronic rhinosinusitis. The aims of the present study were 2-fold: (1) to determine the stimulatory effect of tumor necrosis factor-α (TNF-α) on IL-33 production in nasal epithelial and A549 cells; and (2) to identify downstream pathways that activate IL-33 production. Methods Primary nasal epithelial cells (PNECs) from 5 normal patients were isolated and cultured. To identify which cy... περισσότερα »
Retromaxillary Pneumatization of Posterior Ethmoid Air Cells: Novel Description and Surgical Implications
Objective Retromaxillary pneumatization of posterior ethmoid (PE) air cells is an area that is yet to have appropriate description in rhinologic literature. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods First, 524 sides in 262 paranasal sinus computed tomography scans were analyzed: 350 normal sides were examined for PE pneumatization lateral to the sagittal plane of the medial wall of maxillary sinus posteriorly, and 174 diseased sides were similarly reviewed to check how pathology may affect identification and measurements.... περισσότερα »
Pediatric Oral Electrical Burns: Incidence of Emergency Department Visits in the United States, 1997-2012
Objectives To investigate the epidemiology of emergency department visits for pediatric patients presenting with electrical burns to the mouth. Study Design Cross-sectional analysis of a national database. Setting National Electronic Injury Surveillance System Database. Subjects and Methods The Consumer Product Safety Commission's National Electronic Injury Surveillance System database was used to derive a national weighted estimate of emergency department visits for oral electrical burns and was queried for each patient's age, sex, race, local of incidence, disposition, and ... περισσότερα »
Neural Mechanisms Contributing to Dysphagia in Mouse Models
Investigative research into curative treatments for dysphagia is hindered by our incomplete understanding of the neural mechanisms of swallowing in health and disease. Development of translational research models is essential to bridge this knowledge gap by fostering innovative methodology. Toward this goal, our laboratory has developed a translational research assessment tool to investigate the neural mechanistic control of swallowing in unrestrained, self-feeding mice. Here we describe our initial development of synchronous brainstem neural recordings with a videofluoroscopic sw... περισσότερα »
Laryngopharyngeal Reflux Has Negative Effects on Taste and Smell Functions
Objective We evaluated the halimetric, olfactory, and taste functions of patients with laryngopharyngeal reflux (LPR). Study Design Prospective clinical study. Setting Multicenter tertiary care hospital. Methods Patients who were diagnosed with LPR for the first time on the basis of a Reflux Finding Score (RFS) >11 and a Reflux Symptom Index (RSI) >13 were enrolled in this study. A control group was selected from patients without a complaint of LPR. OralChroma was used for the halimetric measurement; Sniffin' Sticks were used for the smelling test; Taste Strips were used for ... περισσότερα »
Prognostic Factors in Myoepithelial Carcinoma of the Major Salivary Glands
Objectives (1) Identify all cases of myoepithelial carcinoma of the major salivary glands from the National Cancer Data Base (NCDB). (2) Analyze the effect of grade, stage, and regional nodal metastasis on survival in myoepithelial carcinoma of the major salivary glands. Study Design Retrospective review of NCDB. Setting Multicenter data pooled from 1998 to 2012 in the NCDB. Methods We identified all reported cases of myoepithelial carcinomas of the major salivary glands from the United States from 1998 to 2012 in the NCDB. Clinical parameters were then examined and analyzed ... περισσότερα »
A Low-Cost Method of Ciliary Beat Frequency Measurement Using iPhone and MATLAB: Rabbit Study
Objectives (1) To determine ciliary beat frequency (CBF) using a consumer-grade cellphone camera and MATLAB and (2) to evaluate the effectiveness and accuracy of the proposed method. Study Design Prospective animal study. Setting Academic otolaryngology department research laboratory. Methods Five ex vivo tracheal samples were extracted from 3 freshly euthanized (<3 hours postmortem) New Zealand white rabbits and incubated for 30 minutes in buffer at 23°C, buffer at 37°C, or 10% formalin at 23°C. Samples were sectioned transversely and observed under a phase-contrast microsco...περισσότερα »
Randomized Trial of Vitamin C/E Complex for Prevention of Radiation-Induced Xerostomia in Patients with Head and Neck Cancer
Objective The present study was conducted to determine the preventive efficacy of vitamin C/E complex supplementation for radiotherapy (RT)–induced xerostomia in patients with head and neck cancer. Study Design Prospective, double-blinded, randomized, placebo-controlled study. Setting A single tertiary referral institution. Subjects and Methods The trial group (n = 25) received antioxidant supplements (100 IU of vitamin E + 500 mg of vitamin C) twice per day during RT, while the control group (n = 20) received an identical placebo. Pre-RT and 1 and 6 months post-RT, patient-r... περισσότερα »
In-Office Secondary Tracheoesophageal Puncture with Immediate Prosthesis Placement
from #ENT via xlomafota13 on Inoreader http://ift.tt/1S10BiG via IFTTT
Papillary Thyroid Carcinoma : Contrast-Enhanced Multi-Detector CT (64 Channels) Protocol
Feasibility Study of a Contrast-Enhanced Multi-Detector CT (64 Channels) Protocol for Papillary Thyroid Carcinoma: The Influence of Different Scan Delays on Tumor Conspicuity: Thyroid , Vol. 0, No. 0. Author information Young Hen Lee,1* Hyung Suk Seo,1 Sang-il Suh,1 Inseon Ryoo,1 Sung-Hye You,1 Kyu Ri Son,1 Soon-Young Kwon,2 Gil Soo Son,3 and Kyung-Sook Yang4 1Department of Radiology, Korea University College of Medicine, Seoul, Republic of Korea. 2Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea. 3Department of... περισσότερα »
The surgical plane for lingual tonsillectomy
*: an anatomic study: The presence of a plane between the lingual tonsils and the underlying soft tissue has not been confirmed. * Abstract Background *The presence of a plane between the lingual tonsils and the underlying soft tissue has not been confirmed. The objective of this study is to ascertain the presence and the characteristics about this plane for surgical use.* Methods *Five cadaver heads were obtained for dissection of the lingual tonsils. Six permanent sections of previous tongue base biopsies were reviewed. Robot assisted lingual tonsillectomy was performed using ... περισσότερα »
Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship
Cues from social partners trigger the activation of socially responsive neuromodulatory systems, priming brain regions including sensory systems to process these cues appropriately. The fidelity with which neuromodulators reflect the qualities of ongoing social interactions in sensory regions is unclear. We addressed this issue by using voltammetry to monitor serotonergic fluctuations in an auditory midbrain nucleus, the inferior colliculus (IC), of male mice (*Mus musculus*) paired with females, and by concurrently measuring behaviors of both social partners. Serotonergic activit... περισσότερα »
Tactile texture signals in primate primary somatosensory cortex and their relation to subjective roughness intensity
This study investigated the hypothesis that a simple intensive code, based on mean firing rate, could explain the cortical representation of subjective roughness intensity and its invariance with scanning speed. We examined the sensitivity of neurons in the cutaneous, finger representation of primary somatosensory cortex (S1) to a wide range of textures [1 mm high, raised-dot surfaces; spatial periods (SPs), 1.5–8.5 mm], scanned under the digit tips at different speeds (40–115 mm/s). Since subjective roughness estimates show a monotonic increase over this range and are independent...περισσότερα »
Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry
Gamma oscillations are a robust component of sensory responses but are also part of the background spontaneous activity of the brain. To determine whether the properties of gamma oscillations in cortex are specific to their mechanism of generation, we compared in mouse visual cortex in vivo the laminar geometry and single-neuron rhythmicity of oscillations produced during sensory representation with those occurring spontaneously in the absence of stimulation. In mouse visual cortex under anesthesia (isoflurane and xylazine), visual stimulation triggered oscillations mainly between ... περισσότερα »
KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction
Saltatory conduction in mammalian myelinated axons was thought to be well understood before recent discoveries revealed unexpected subcellular distributions and molecular identities of the K+-conductance pathways that provide for rapid axonal repolarization. In this study, we visualize, identify, localize, quantify, and ultrastructurally characterize axonal KV 1.1/KV1.2 channels in sciatic nerves of rodents. With the use of light microscopic immunocytochemistry and freeze-fracture replica immunogold labeling electron microscopy, KV1.1/KV1.2 channels are localized to three anatomica... περισσότερα »
Selection of head and whisker coordination strategies during goal-oriented active touch
In the rodent whisker system, a key model for neural processing and behavioral choices during active sensing, whisker motion is increasingly recognized as only part of a broader motor repertoire employed by rodents during active touch. In particular, recent studies suggest whisker and head motions are tightly coordinated. However, conditions governing the selection and temporal organization of such coordinated sensing strategies remain poorly understood. We videographically reconstructed head and whisker motions of freely moving mice searching for a randomly located rewarded apert...περισσότερα »
Temporal accuracy of human cortico-cortical interactions
The precision in space and time of interactions among multiple cortical sites was evaluated by examining repeating precise spatiotemporal patterns of instances in which cortical currents showed brief amplitude undulations. The amplitudes of the cortical current dipoles were estimated by applying a variant of synthetic aperture magnetometry to magnetoencephalographic (MEG) recordings of subjects tapping to metric auditory rhythms of drum beats. Brief amplitude undulations were detected in the currents by template matching at a rate of 2–3 per second. Their timing was treated as poin... περισσότερα »
Reconsidering first-line treatment for obstructive sleep apnea
*: a systematic review of the literature: Continuous positive airway pressure (CPAP) is typically recommended as first line therapy for obstructive sleep apnea, but the adherence rate of CPAP is problematic. * Abstract Background *Continuous positive airway pressure (CPAP) is typically recommended as first line therapy for obstructive sleep apnea, but the adherence rate of CPAP is problematic. This study’s objective was to systematically review the literature relating to CPAP as first line therapy for OSA and compare it to surgical literature on the same topic.* Methods *A syste... περισσότερα »
Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies
Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies: Thyroid , Vol. 0, No. 0. Author information Tanja Diana,1* Yunsheng Li,2* Paul D. Olivo,2 Karl J. Lackner,3 Hannah Kim,2 Michael Kanitz,1 andGeorge J. Kahaly1 1Molecular Thyroid Research Laboratory, Johannes Gutenberg University Medical Center, Mainz, Germany. 2Research & Development, Quidel Corporation, San Diego, California. 3Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, Mainz,Germany. *These authors contributed equally to this work. Address... περισσότερα »
Salivary Stone Pneumatic Lithotripsy
in a Live Porcine Model: The purpose of this study is to evaluate the efficacy of endoscopic fragmentation and removal of artificial calculi in a live porcine model employing intracorporeal pneumatic lithotripsy. In this experimental study, 7 submandibular ducts were accessed and artificial calculi placed. A salivary pneumatic lithotripter probe was inserted through an interventional sialendoscope to fragment the calculi. A salivary duct catheter was then used to flush stone fragments, followed by endoscopy to assess complete fragmentation and ductal trauma. Ultimately, 7 artifici... περισσότερα »
Successful Use of Radiotherapy for Pterygopalatine Fossa Amyloidosis
Successful Use of Radiotherapy for Pterygopalatine Fossa Amyloidosis:
Analysis of Outcome Domains in Adult Cochlear Implantation
: A Systematic Review: Objectives To determine the breadth of outcome domains used in the reporting of adult cochlear implant surgery for the purpose of registry and quality measure development. Data Sources Systematic review of randomized controlled trials. Review Methods In consultation with a medical librarian, search strategies were constructed to identify randomized controlled trials studying adults undergoing cochlear implantation. MEDLINE, EMBASE, Scopus, CINAHL, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and the Database of Ab... περισσότερα »
Patient- or Proxy-Reported Validated Instruments Assessing Pediatric Dysphagia
A Systematic Review of Pediatric dysphagia occurs in 500,000 children each year; however, there is not a common tool to assess these children. Our aim was to identify validated patient- or parent-reported outcome assessment tools evaluating pediatric dysphagia. Data Sources Scopus, EMBASE, PubMed, Cochrane Library, and CINAHL electronic databases (all indexed years through August 2014). Review Methods Inclusion criteria included English-language articles containing instruments evaluated in children. Two investigators independently reviewed all articles, and the review was perf...περισσότερα »
Pediatric Posttonsillectomy Hemorrhage
Demographic and Geographic Variation in Health Care Costs in the United States: Objective To examine variations in management of pediatric posttonsillectomy hemorrhage and associated costs from a national third-party payer perspective. Study Design The MarketScan database was analyzed for claims made for 30 days following tonsillectomy/adenotonsillectomy between 2008 and 2012 for privately insured children aged 1 to 17 years. Costs for management of postoperative hemorrhage by age, sex, and region were calculated in addition to total costs incurred for 30 days postoperatively. Se... περισσότερα »
Computational Modeling of Airway Obstruction in Sleep Apnea in Down Syndrome
: A Feasibility Study: Current treatment options are successful in 40% to 60% of children with persistent obstructive sleep apnea after adenotonsillectomy. Residual obstruction assessments are largely subjective and do not clearly define multilevel obstruction. We endeavor to use computational fluid dynamics to perform virtual surgery and assess airflow changes in patients with Down syndrome and persistent obstructive sleep apnea. Three-dimensional airway models were reconstructed from respiratory-gated computed tomography and magnetic resonance imaging. Virtual surgeries were perf... περισσότερα »
Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk
Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk: Objective Upper airway obstruction (UAO) can result in cardiac complications, including arrhythmias and sudden cardiac death. Nasal septum deviation (NSD) is a common cause of UAO. The aim of this study was to assess the risk of cardiac arrhythmias in patients with NSD. To assess this risk, we measured noninvasive indicators of atrial arrhythmia (P-wave dispersion [Pd]) and ventricular arrhythmia (corrected QT dispersion [QTcd]) and compared these values between NSD patients and healthy subjects. Study De...περισσότερα »
Computer-Aided Design and 3D Printing to Produce a Costal Cartilage Model for Simulation of Auricular Reconstruction
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Informed Consent in Pediatric Otolaryngology: What Risks and Benefits Do Parents Recall?
Objective To evaluate parental recall of surgical risks and benefits in pediatric otolaryngology and to assess for factors that may influence recall. Study Design Prospective cohort study. Setting Academic pediatric otolaryngology clinic. Subjects and Methods Eighty-four parents of children <6 years of age who underwent consultation for adeno/tonsillectomy and/or tympanostomy tube insertion were prospectively enrolled. Consultation visits were video recorded and the benefits and risks of surgery documented. Two weeks following the consultation, parents were contacted for asse... περισσότερα »
Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk
Objective Upper airway obstruction (UAO) can result in cardiac complications, including arrhythmias and sudden cardiac death. Nasal septum deviation (NSD) is a common cause of UAO. The aim of this study was to assess the risk of cardiac arrhythmias in patients with NSD. To assess this risk, we measured noninvasive indicators of atrial arrhythmia (P-wave dispersion [Pd]) and ventricular arrhythmia (corrected QT dispersion [QTcd]) and compared these values between NSD patients and healthy subjects. Study Design Prospective study. Settings Tertiary referral center. Subjects and M...περισσότερα »
Computational Modeling of Airway Obstruction in Sleep Apnea in Down Syndrome: A Feasibility Study
Current treatment options are successful in 40% to 60% of children with persistent obstructive sleep apnea after adenotonsillectomy. Residual obstruction assessments are largely subjective and do not clearly define multilevel obstruction. We endeavor to use computational fluid dynamics to perform virtual surgery and assess airflow changes in patients with Down syndrome and persistent obstructive sleep apnea. Three-dimensional airway models were reconstructed from respiratory-gated computed tomography and magnetic resonance imaging. Virtual surgeries were performed on 10 patients, ... περισσότερα »
Parental recall of surgical risks and benefits in pediatric otolaryngology
Informed Consent in Pediatric Otolaryngology: What Risks and Benefits Do Parents Recall?: Objective To evaluate parental recall of surgical risks and benefits in pediatric otolaryngology and to assess for factors that may influence recall. Study Design Prospective cohort study. Setting Academic pediatric otolaryngology clinic. Subjects and Methods Eighty-four parents of children <6 years of age who underwent consultation for adeno/tonsillectomy and/or tympanostomy tube insertion were prospectively enrolled. Consultation visits were video recorded and the benefits and risks of su... περισσότερα »
Ependymoma Awareness Day
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Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.
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Tocagen to Present at Three Oncology Conferences
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March Madness Brain Cancer Fundraiser in Memory of Wilton Woman’s Sister
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CNY 6-year-old with aggressive cancer beating odds with `superhero` treatment
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Data Safety and Monitoring Board Recommends Celldex`s Phase 3 Study of RINTEGA® (rindopepimut) in Newly Diagnosed Glioblastoma be Discontinued as it is Unlikely to Meet Primary Overall Survival Endpoint in Patients with Minimal Residual Disease
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Correction on Celldex article
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The Curcumin Analog C-150, Influencing NF-?B, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.
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Evaluation of Sodium Polystyrene Sulfonate Dosing Strategies in the Inpatient Management of Hyperkalemia
Background: Hyperkalemia occurs frequently in an inpatient setting, for which sodium polystyrene sulfonate (SPS) is a common treatment modality. Few studies have investigated the dose-response of SPS. Objective: To quantify the change in serum potassium after 15-, 30-, and 60-g oral and 30-g rectal doses of SPS. Secondary objectives were to compare the proportion of… Continue reading Evaluation of Sodium Polystyrene Sulfonate Dosing Strategies in the Inpatient Management of Hyperkalemia
Localized Bullous Eruption Away From Injection Site, Caused by Intramuscular Meglumine Antimoniate Administration
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Vitamin C/E Complex for Prevention of Radiation-Induced Xerostomia
in Patients with Head and Neck Cancer: Objective The present study was conducted to determine the preventive efficacy of vitamin C/E complex supplementation for radiotherapy (RT)–induced xerostomia in patients with head and neck cancer. Study Design Prospective, double-blinded, randomized, placebo-controlled study. Setting A single tertiary referral institution. Subjects and Methods The trial group (n = 25) received antioxidant supplements (100 IU of vitamin E + 500 mg of vitamin C) twice per day during RT, while the control group (n = 20) received an identical placebo. Pre-RT a... περισσότερα »
Biologic Treatment Registry Across Canada (BioTRAC): a multicentre, prospective, observational study of patients treated with infliximab for ankylosing spondylitis
Objectives To describe the profile of patients with ankylosing spondylitis (AS) treated with infliximab in Canadian routine care and to assess the effectiveness and safety of infliximab in real world. Setting 46 primary care rheumatology practices across Canada. Participants 303 biological-naïve patients with AS or patients previously treated with a biological for <6 months and who were eligible for infliximab treatment as per routine care within the Biologic Treatment Registry Across Canada (BioTRAC). Intervention Not applicable (non-interventional study). Primary and secon... περισσότερα »
Ciliary Beat Frequency Measurement Using iPhone and MATLAB
A Low-Cost Method of Ciliary Beat Frequency Measurement Using iPhone and MATLAB: Rabbit Study: Objectives (1) To determine ciliary beat frequency (CBF) using a consumer-grade cellphone camera and MATLAB and (2) to evaluate the effectiveness and accuracy of the proposed method. Study Design Prospective animal study. Setting Academic otolaryngology department research laboratory. Methods Five ex vivo tracheal samples were extracted from 3 freshly euthanized (<3 hours postmortem) New Zealand white rabbits and incubated for 30 minutes in buffer at 23°C, buffer at 37°C, or 10% formal... περισσότερα »
Myoepithelial Carcinoma of the Major Salivary Glands
Prognostic Factors in (1) Identify all cases of myoepithelial carcinoma of the major salivary glands from the National Cancer Data Base (NCDB). (2) Analyze the effect of grade, stage, and regional nodal metastasis on survival in myoepithelial carcinoma of the major salivary glands. Study Design Retrospective review of NCDB. Setting Multicenter data pooled from 1998 to 2012 in the NCDB. Methods We identified all reported cases of myoepithelial carcinomas of the major salivary glands from the United States from 1998 to 2012 in the NCDB. Clinical parameters were then examined an... περισσότερα »
Laryngopharyngeal Reflux on Taste and Smell Functions
Laryngopharyngeal Reflux Has Negative Effects on Taste and Smell Functions: Objective We evaluated the halimetric, olfactory, and taste functions of patients with laryngopharyngeal reflux (LPR). Study Design Prospective clinical study. Setting Multicenter tertiary care hospital. Methods Patients who were diagnosed with LPR for the first time on the basis of a Reflux Finding Score (RFS) >11 and a Reflux Symptom Index (RSI) >13 were enrolled in this study. A control group was selected from patients without a complaint of LPR. OralChroma was used for the halimetric measurement; Sn...περισσότερα »
Neural Mechanisms Contributing to Dysphagia
in Mouse Models: Investigative research into curative treatments for dysphagia is hindered by our incomplete understanding of the neural mechanisms of swallowing in health and disease. Development of translational research models is essential to bridge this knowledge gap by fostering innovative methodology. Toward this goal, our laboratory has developed a translational research assessment tool to investigate the neural mechanistic control of swallowing in unrestrained, self-feeding mice. Here we describe our initial development of synchronous brainstem neural recordings with a vi... περισσότερα »
Pediatric Oral Electrical Burns
: Incidence of Emergency Department Visits in the United States, 1997-2012: Objectives To investigate the epidemiology of emergency department visits for pediatric patients presenting with electrical burns to the mouth. Study Design Cross-sectional analysis of a national database. Setting National Electronic Injury Surveillance System Database. Subjects and Methods The Consumer Product Safety Commission’s National Electronic Injury Surveillance System database was used to derive a national weighted estimate of emergency department visits for oral electrical burns and was queried... περισσότερα »
Retromaxillary Pneumatization of Posterior Ethmoid Air Cells
: Novel Description and Surgical Implications: Objective Retromaxillary pneumatization of posterior ethmoid (PE) air cells is an area that is yet to have appropriate description in rhinologic literature. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods First, 524 sides in 262 paranasal sinus computed tomography scans were analyzed: 350 normal sides were examined for PE pneumatization lateral to the sagittal plane of the medial wall of maxillary sinus posteriorly, and 174 diseased sides were similarly reviewed to check how pathology ... περισσότερα »
Rate discrimination at low pulse rates in normal-hearing and cochlear implant listeners: Influence of intracochlear stimulation sitea)
Rate discrimination at low pulse rates in normal-hearing and cochlear implant listeners: Influence of intracochlear stimulation sitea): [image: cm_sbs_024_plain.png] Temporal pitch perception in cochlearimplantees remains weaker than in normal hearing listeners and is usually limited to rates below about 300 pulses per second (pps). Recent studies have suggested that stimulating the apical part of the cochlea may improve the temporal coding of pitch by cochlear implants(CIs), compared to stimulating other sites. The present study focuses on rate discrimination at low pulse rates (r... περισσότερα »
The effects of HIV self-testing on the uptake of HIV testing and linkage to antiretroviral treatment among adults in Africa: a systematic review protocol
HIV is still a global public health problem. More than 75 % of HIV-infected people are in Africa, and most of them are unaware of their HIV status, which is a barrier to accessing antiretroviral treatment. Our... from #Medicine via ola Kala on Inoreader http://ift.tt/23eJDPU via IFTTT
